A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
girinimbine. Alternative Names: 3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole. CAS No. 23095-44-5. Purity: 95%+. Product ID: ACM23095445-1. Molecular formula: C18H17NO. Mole weight: 263.3. Alfa Chemistry - ISO 9001:32057 Certified.
Girinimbine
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Girinimbin. CAS No. 23095-44-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9488.
Girinimbine
Girinimbine is a natural compound which can be isolated from Clausena vestita, Murraya euchrestifolia, etc. Alternative Names: 3,11-Dihydro-3,3,5-trimethyl-Pyrano(3,2-a)carbazole; Pyrano(3,2-a)carbazole, 3,11-dihydro-3,3,5-trimethyl-. Grades: 98%. CAS No. 23095-44-5. Molecular formula: C18H17NO. Mole weight: 263.33.
Giripladib
Giripladib inhibits cytosolic phospholipase A2 (cPLA2) which in turn radiosensitizes tumors in lung cancer animal models. Group: Biochemicals. Grades: Highly Purified. CAS No. 865200-20-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C41H36ClF3N2O4S, Molecular Weight: 745.25. US Biological Life Sciences.
Worldwide
Giripladib
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PLA-695. CAS No. 865200-20-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-14952.
Girolline
It is produced by the strain of Pseudaxinyssa cantharella. It can inhibit protein biosynthesis and has anti-tumor effect. Alternative Names: Giracodazole; Girodazole; Giracodazolum; (alphaS)-2-Amino-alpha-((1S)-2-amino-1-chloroethyl)imidazole-4-methanol; (1S,2S)-1-(2-Amino-5-imidazolyl)-2-chloro-3-amino-1-propanol. Grades: 95%. CAS No. 110883-46-0. Molecular formula: C6H11ClN4O. Mole weight: 190.63.
Gisadenafil
Gisadenafi is a potent PDE5 inhibitor (IC50 = 1.23 nM). Uses: A potent pde5 inhibitor. Alternative Names: UK-369003; UK-369,003; 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine. Grades: ≥98%. CAS No. 334826-98-1. Molecular formula: C23H33N7O5S. Mole weight: 519.62.
Gisadenafil besylate
Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM) with >100-fold selectivity for PDE5 over PDE6. Gisadenafil besylate inhibits the breakdown of cyclic phosphodiester secondary messenger molecules. Alternative Names: UK 369003; UK369003; UK-369003; 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate. Grades: ≥99% by HPLC. CAS No. 334827-98-4. Molecular formula: C23H33N7O5S.C6H6O3S. Mole weight: 677.79.
Gisadenafil Besylate
Gisadenafil Besylate. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one Benzenesulfonate; 1-[[6-Ethoxy-5-[3-ethyl-4,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridinyl]sulfonyl]-4-ethylpiperazine Monobenzenesulfonate; UK 369003-26. Grades: Highly Purified. CAS No. 334827-98-4. Pack Sizes: 10mg. Molecular Formula: C29H39N7O8S2, Molecular Weight: 677.79. US Biological Life Sciences.
Worldwide
GIT 27
GIT 27. Group: Biochemicals. Grades: Purified. CAS No. 6501-72-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
GIT 27
GIT 27 is an orally active immunomodulatory agent. It inhibits TNF-α secretion via interference of macrophage TLR4 and TLR 2/6 signaling pathway. Alternative Names: 5-Dihydro-3-phenyl-5-isoxazoleacetic acid; (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid; 3-phenyl-4,5-dihydro-5-isoxazole acetic acid; VGX-1027; VGX 1027; VGX1027; GIT 27; GIT-27; GIT27. CAS No. 6501-72-0. Molecular formula: C11H11NO3. Mole weight: 205.21.
Gitaloxin
Gitaloxin. Alternative Names: [(3S,5R,8R,9S,10S,13R,14S,16S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-17-(5-oxo-2H-furan-3-yl)-1,2,3,4,5,6,7,8,9,; Gitaloxin; O(16)16-formylgitoxin; Gitaloxigenin-tridigitoxosid; 16-Formyl-gitoxin; Gitoxin16-formate. Grades: 95%. CAS No. 3261-53-8. Molecular formula: C42H64O15. Mole weight: 808.953.
Gitogenin
Gitogenin. Group: Biochemicals. Alternative Names: (2alpha,3 β,5alpha,25R)-Spirostan-2,3-diol; Digine. Grades: Plant Grade. CAS No. 511-96-6. Pack Sizes: 20mg. Molecular Formula: C27H44O4, Molecular Weight: 432.636. US Biological Life Sciences.
Worldwide
Gitogenin
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 511-96-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2574.
Gitoxigenin
Gitoxigenin is a naturally occurring diterpenoid compound found in a variety of plant species. It has been used as an inhibitor of the enzyme cyclooxygenase (COX) and a Na+/K+-ATPase inhibitor. Alternative Names: 16beta-Hydroxydigitoxigenin; 5β,20(22)-Cardenolide-3β,14,16β-triol; 3-beta,14,16-trioxycarden-(20:22)-olid. Grades: 98%. CAS No. 545-26-6. Molecular formula: C23H34O5. Mole weight: 390.51.
Gitoxin
Gitoxin. Group: Biochemicals. Alternative Names: Gitoxigenin 3-O-tridigitoxoside; Anhydrogitalin. Grades: Highly Purified. CAS No. 4562-36-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C41H64O14. US Biological Life Sciences.
Worldwide
Gitoxin
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na+/K+-ATPase inhibitor, with an IC50 of 1.18e-6 M against the porcine high-affinity subtype and an IC50 of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4562-36-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136933.
GIV3727
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 957136-80-0. Pack Sizes: 1 mg (50.43 mM * 100 μL in Methanol); 5 mg (50.43 mM * 500 μL in Methanol); 10 mg (50.43 mM * 1 mL in Methanol). Product ID: HY-124956.
Givastomig
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TJ-CD4B; ABL111; TJ033721. CAS No. 2762499-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990742.
Givescone ®
Givescone ®. CAS No. 57934-97-1. Kosher: Y. VIGON Item # 500893. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, rose carboxylate.
America & Internationally
GIVESCONE
GIVESCONE. Alternative Names: 2-Cyclohexene-1-carboxylicacid,2-ethyl-6,6-dimethyl-,ethylester; 2-ethyl-6,6-dimethyl-2-cyclohexene-1-carboxylicaciethylester; GIVESCONE; ethyl 2-ethyl-6,6-dimethylcyclohex-2-ene-1-carboxylate; Ethyl-2-ethyl-6,6-dimethylcyclohex-2-en-1-carboxylat; 2-Ethyl-6,6. CAS No. 57934-97-1. Molecular formula: C13H22O2. Mole weight: 210.31.
Givinostat
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research. Givinostat can penetrate the blood-brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITF-2357. CAS No. 497833-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14842.
Givinostat hydrochloride monohydrate
Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride monohydrate can penetrate the blood-brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITF-2357 hydrochloride monohydrate. CAS No. 732302-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14842B.
Givosiran
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-AS1. CAS No. 1639325-43-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132610.
Givosiran
Givosiran. CAS No. 1639325-43-1.
Givosiran sodium
Givosiran sodium is a small interfering RNA (siRNA) directed towards delta-aminolevulinate synthase 1 (ALAS1). Givosiran sodium has been indicated for the treatment of adults with acute hepatic porphyria (AHP). Alternative Names: ALN-AS1 sodium; ALN AS1 sodium; ALN-AS 1 sodium; WHO 10280 sodium; WHO-10280 sodium; WHO10280 sodium; Givlaari sodium; RNA, (Cm-sp-Am-sp-Gm-Am-Am-Am-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)C-Am-Um-Cm-Um-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Gm-sp-Gm-sp-Um) (1:1) sodium salt. Grades: 98%. Molecular formula: C524H651F16N173Na43O316P43S6. Mole weight: 17,245.56 Da.
Givosiran sodium
Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-AS1 sodium. CAS No. 1639325-44-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132610A.
GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with Kd values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3099808-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-174830.
GK921 is a transglutaminase 2 (TGase) inhibitor with an IC50 of 7.71 μM for human recombinant TGase 2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1025015-40-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12337.
GKA 50
GKA 50. Group: Biochemicals. Grades: Purified. CAS No. 851884-87-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
GKI-1
GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2444764-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100521.
GKT136901
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 955272-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101499.
GKT136901 hydrochloride
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254507-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101499A.
GL0388
GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC50s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2886772-68-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132173.
GL64
GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 μM). GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 488801-10-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175232.
GL67
Genzyme Lipid 67 is a cholesterol derivatized with spermine to create a cationic lipid. GL67 has been proven to efficiently mediate gene transfer into mammalian cells and was a key formulation component that successfully completed clinical studies for the delivery of pDNA via inhalation. Alternative Names: N4-Cholesteryl-Spermine; Cholest-5-en-3-ol (3β)-, 3-[(3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate]; Cholest-5-en-3-ol (3β)-, (3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate; Cholesterol (3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate; GL 67; N4-Spermine cholesteryl carbamate. CAS No. 179075-30-0. Molecular formula: C38H70N4O2. Mole weight: 614.99.
Glabralide A
Glabralide A is a kind of a unique skeleton of the chalcone-coupled monoterpenoid. It has a bicyclo [2.2.2] octene core unit with five chiral centers. Alternative Names: Glabralide A; 1969289-10-8; B0005-267493. Grades: 97.0%. CAS No. 1969289-10-8. Molecular formula: C27H32O5. Mole weight: 436.00.
Glabralide B
Glabralide B is an enchanting natural compound, manifesting an impeccable amalgamation of anti-inflammatory and antioxidant effects. Alternative Names: Glabralide B; 2170388-84-6; AKOS040760805. Grades: 98.0%. CAS No. 2170388-84-6. Molecular formula: C21H26O3. Mole weight: 326.436.
Glabralide C
Glabralide C, an organic compound derived from the Astragalus glabrescens blossoms, has been shown to exhibit neuroprotection and could be a promising treatment for neurodegenerative disorders like Alzheimer's. Alternative Names: Glabralide C; 2170388-85-7. Grades: 96.0%. CAS No. 2170388-85-7. Molecular formula: C29H40O4. Mole weight: 452.634.
Glabranin
Glabranin is a natural flavonoid isolated from the roots of Glycyrrhiza uralensis Fisch. Alternative Names: (2S)-2,3-Dihydro-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-2-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (S)-; Glabranin (flavonoid); Glabranine; 8-Prenylpinocembrin; 8-Dimethylallylpinocembrin. Grades: >98%. CAS No. 41983-91-9. Molecular formula: C20H20O4. Mole weight: 324.37.
Glabratine
Glabratine is a glucoalkaloid isolated from Uncaria glabrata. Grades: 97.5%. CAS No. 142750-47-8. Molecular formula: C27H34N2O9. Mole weight: 530.575.
Glabredelphinine
Glabredelphinine, a naturally occurring substance, has garnered attention for its remarkable efficacy in inducing apoptosis in tumors, thus displaying its potent anti-tumor activity. Furthermore, it has exhibited potential therapeutic benefits in the treatment of Alzheimer's disease by impeding acetylcholinesterase activity. Through its multifaceted mechanisms, Glabredelphinine represents an intriguing candidate for further exploration within both oncological and neurological research domains. Alternative Names: Glabredelphinine; 132160-37-3; (3R,4S,5S,6S,8R,13R,16S,17R,18S)-11-ethyl-6-methoxy-13-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadec-14-ene-4,8,9,16,18-pentol(2R,3R,4S,5S,6S,8R,13R,16S,17R,18S)-11-ethyl-6-methoxy-13-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadec-14-ene-4,8,9,16,18-pentol. Grades: 97.5%. CAS No. 132160-37-3. Molecular formula: C22H33NO6. Mole weight: 407.507.
Glabrene
Glabrene is a natural flavonoid compound found in several plants. Alternative Names: 2',2'-Dimethyl-3,6'-bi[2H-1-benzopyran]-5',7-diol;2',2'-Dimethyl-[3,8'-bi-2H-1-benzopyran]-5',7-diol. Grades: >97%. CAS No. 60008-03-9. Molecular formula: C20H18O4. Mole weight: 322.35.
Glabrescione B
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65893-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122590.
Glabridin
Glabridin. Group: Biochemicals. Alternative Names: 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol. Grades: Highly Purified. CAS No. 59870-68-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C20H20O4. US Biological Life Sciences.
Worldwide
Glabridin
Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. It has been reported to possess various biological activities, including strong antioxidant activity, anti-LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity, anti-nephropathy, and free radical scavenging activity. It retains anti-inflammatory abilities to regulate the synthesis and activity of iNOS under high-glucose levels, implying that a Glabridin supplement may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction. It inhibited the invasion of human HCC cells and may have potential as a chemopreventive agent against liver cancer metastasis. It exhibits antiplasmodial activity and is suitable for developing antimalarial agent from a cheap and sustainable source. It may possess a therapeutic effect on metabolic disorders, such as diabetes and hyperglycemia, by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin is also a key ingredient used in cosmetics. It has whitening, anti-inflammatory, antibacterial and antioxidant effects. Alternative Names: 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol; 4-((R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-B:4,3-B']dipyran-3-yl)-benzene-1,3-diol; (R)-4-(8,8-dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)benzene-1,3-diol; (R)-Glabridin. Grades: >98%. CAS No. 59870-68-7. Molecular fo
Glabridin
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59870-68-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0393.
Glabrol
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59870-65-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N4193.
Glabrol
Glabrol is a flavonoid showing inhibition of PTP1B and CYP1B1. Alternative Names: Glabrol; 59870-65-4; UNII-E4XEY076JN; E4XEY076JN; (S)-7-Hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-8-(3-methylbut-2-en-1-yl)chroman-4-one; MLS000697605; (2S)-7-hydroxy-2-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one; SMR000470942; 7-Hydroxy-2-(4-hydroxy-3-((E)-3-methyl-but-2-enyl)-phenyl)-8-(3-methyl-but-2-enyl)-1-benzopyran-4-one; 4H-1-BENZOPYRAN-4-ONE, 2,3-DIHYDRO-7-HYDROXY-2-(4-HYDROXY-3-(3-METHYL-2-BUTEN-1-YL)PHENYL)-8-(3-METHYL-2-BUTEN-1-YL)-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxy-3-(methyl-2-butenyl)phenyl)-8-(3-methyl-2-butenyl)-, (2S)-. Grades: 98%. CAS No. 59870-65-4. Molecular formula: C25H28O4. Mole weight: 392.49.
Glabrone
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60008-02-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4194.
Glacial acetic acid
Glacial acetic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 64-19-7. Pack Sizes: 1kg, 2kg, 5kg, 10kg, 25kg. Molecular Formula: C2H4O2. US Biological Life Sciences.
Worldwide
Glacial Acetic Acid
Glacial Acetic Acid. Group: Industrial Chemicals. Purity: Purity: 99.85% Min. CAS No. 64-19-7. Molecular formula: Molecular formula: CH3COOH. UN no: 2789.
Glacial Acetic Acid IP/BP/USP
Glacial Acetic Acid IP/BP/USP. CAS No. 64-19-7. Molecular formula: C2H4O2.
It is produced by the strain of Penicillum gladioli. It has the antifungal activity of Absidia glauca Hagem, garlic spores, Byssochlamys fulva, Trichophyton mentagrophytes, Corpuscular falciparum. Alternative Names: Isogladiolic acid; Gladiolsaeure; 4-methoxy-5-methyl-o-phthaldehyde; puberulonic acid; 2,3-Diformyl-6-methoxy-5-methyl-benzoesaeure. CAS No. 478-05-7. Molecular formula: C11H10O5. Mole weight: 222.19.
Glafenic acid
Glafenic acid. Group: Biochemicals. Alternative Names: 2-[ (7-Chloro-4-quinolinyl) amino]benzoic acid; N-(7-Chloro-4-quinolyl)anthranilic acid; (+)-Glafenic acid. Grades: Highly Purified. CAS No. 10440-42-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C16H11ClN2O2. US Biological Life Sciences.
Worldwide
Glafenine
Glafenine is a non-steroidal analgesic agent, shows significant antiinflammatory activity. Uses: Wdely used for the treatment of pains of various origins. Alternative Names: 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate; 1-Glyceryl N-(7-chloro-4-quinolyl)anthranilate. Grades: ≥98%. CAS No. 3820-67-5. Molecular formula: C19H17ClN2O4. Mole weight: 372.80.
Glafenine
Glafenine. Group: Biochemicals. Alternative Names: 2-[ (7-Chloro-4-quinolinyl) amino]benzoic acid 2,3-dihydroxypropyl ester; 1-[N- (7-Chloro-4-quinolyl) anthranilate]glycerol; N-(7-Chloro-4-quinolyl)anthranilic acid 2,3-dihydroxypropyl ester. Grades: Highly Purified. CAS No. 3820-67-5. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C19H17ClN2O4. US Biological Life Sciences.
Worldwide
Glafenine
Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glafenin. CAS No. 3820-67-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-B1153.
Glafenine (Standard)
Glafenine (Standard) is the analytical standard of Glafenine. This product is intended for research and analytical applications. Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glafenin (Standard). CAS No. 3820-67-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1153R.
Glasdegib
Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduction. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model. Alternative Names: PF-04449913; PF 04449913; 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea. Grades: >98%. CAS No. 1095173-27-5. Molecular formula: C21H22N6O. Mole weight: 374.44.
Glasdegib
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-04449913. CAS No. 1095173-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16391.