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| Product | Description | |
|---|---|---|
| Ginsenoside Rh3 | Ginsenoside Rh3. Group: Biochemicals. Grades: Plant Grade. CAS No. 105558-26-7. Pack Sizes: 10mg. Molecular Formula: C36H60O7, Molecular Weight: 604.86. US Biological Life Sciences. |  Worldwide |
| Ginsenoside RH4 | Ginsenoside RH4. Group: Biochemicals. Grades: Plant Grade. CAS No. 174721-08-5. Pack Sizes: 10mg. Molecular Formula: C36H60O8, Molecular Weight: 620.86. US Biological Life Sciences. | Worldwide |
| Ginsenoside Rk1 | Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures[1].Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB[2].Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis[1].Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 494753-69-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N2515. |  |
| Ginsenoside RK1 | Ginsenoside RK1. Group: Biochemicals. Grades: Plant Grade. CAS No. 494753-69-4. Pack Sizes: 5mg. Molecular Formula: C42H70O12, Molecular Weight: 767. US Biological Life Sciences. | Worldwide |
| Ginsenoside Rk1 (Rk1:Rz1=5:2) | Ginsenoside Rk1 (Rk1:Rz1=5:2). Group: Biochemicals. CAS No. 494753-69-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ginsenoside Rk3 | Ginsenoside Rk3 is reportedly present in the processed Radix notoginseng that is often used as a major ingredient of the compound preparation for ischemic heart diseases. Ginsenoside Rk3 and Rh4 could have a role in treating inflammatory diseases. Uses: Anti-inflammatory/anti-tumor. Grade: >98%. CAS No. 364779-15-7. Molecular formula: C36H60O8. Mole weight: 620.86. |  |
| Ginsenoside Rk3 | Ginsenoside Rk3. Group: Biochemicals. Grades: Plant Grade. CAS No. 364779-15-7. Pack Sizes: 5mg. Molecular Formula: C36H60O8, Molecular Weight: 620.86. US Biological Life Sciences. | Worldwide |
| Ginsenoside Rk3 | Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 364779-15-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0906. | |
| Ginsenoside Ro | Ginsenoside Ro. Group: Biochemicals. Alternative Names: Chikusetsusaponin V; Polysciasaponin P3; Hericiumsaponin S3. Grades: Plant Grade. CAS No. 34367-04-9. Pack Sizes: 20mg. Molecular Formula: C48H76O19, Molecular Weight: 957.105999999999. US Biological Life Sciences. | Worldwide |
| Ginsenoside Ro | Ginsenoside Ro, the predominant ginsenoside in the rhizome, shows inhibitory activity against 5αR. It demonstrates significant anti-thrombic, anti-inflammatory, and anti-hepatitis activities in experimental models. It shows no hemolytic nor cytotoxic activities. Uses: Anti-infllammtory, anti-hepatitic activities. Synonyms: (3b)-28-(b-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-O-(b-D-glucopyranosyl)-b-D-glucopyranosiduronic acid; Chikusetsusaponin; Polysciasaponin P3. Grade: >98%. CAS No. 34367-04-9. Molecular formula: C48H76O19. Mole weight: 957.13. | |
| Gintemetostat | Gintemetostat (KTX-1001) is an orally active, highly specific NSD2/MMSET histone methyltransferase inhibitor with human NSD2 IC50 values ranging 0.460-2.17 nM and NSD2 SET domain IC50 of 2.32 nM and Kd values ranging 6.3-70.4 nM[1][4].Gintemetostat reduces H3K36me2 levels, impairs multiple myeloma cell adhesion and colony formation, enhances cytotoxicity, boosts T-cell activation, and sensitizes resistant multiple myeloma cells to other agents[1][2][6].Gintemetostat can be used for the research of multiple myeloma and relapsed and refractory multiple myeloma[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KTX-1001. CAS No. 2604513-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154812. | |
| GIP (1-39) | GIP (1-39) is an endogenous truncated form of the incretin hormone GIP. GIP (1-39) has the high potency at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP. Synonyms: Gastric Inhibitory Polypeptide (1-39). CAS No. 725474-97-5. Molecular formula: C210H316N56O61S. Mole weight: 4633.21. | |
| GIP (3-42), human | GIP (3-42), human acts as a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist, moderating the insulin secreting and metabolic actions of GIP in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802086-25-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2542. | |
| GIP (human) | GIP (human) is a potent insulinotropic hormone synthesized by duodenal K-cells. It inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Synonyms: Gastric Inhibitory Polypeptide human; Gastric Inhibitory Polypeptide (human); Gastric Inhibitory Peptide (GIP), human; Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln. Grade: 95%. CAS No. 100040-31-1. Molecular formula: C226H338N60O66S. Mole weight: 4983.58. | |
| GIP, human | GIP, human, a peptide hormone consisting of 42 amino acids, is a stimulator of glucose-dependent insulin secretion and a weak inhibitor of gastric acid secretion. GIP, human acts as an incretin hormone released from intestinal K cells in response to nutrient ingestion[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gastric Inhibitory Peptide (GIP), human. CAS No. 100040-31-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0276. | |
| GIP (mouse) | GIP (Gastric inhibitory polypeptide) (mouse) is a gastrointestinal hormone that is secreted by the intestinal K cells, and also expressed in and secreted from pancreatic islets. GIP (mouse) promotes insulin secretion from pancreatic β cells via the G-protein-coupled GIP receptor (GIPR). GIP (mouse) promotes pancreatic β cell proliferation and inhibits apoptosis. GIP (mouse) also exerts direct lipogenic effects on adipose tissue[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gastric inhibitory polypeptide(mouse); GIP(1-42) (mouse). CAS No. 181591-59-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10735. | |
| Girard's Reagent D | Girard's Reagent D. Uses: For analytical and research use. Alternative Names: N,N-Dimethylglycine Hydrazide Dihydrochloride. CAS No. 5787-71-3. Molecular formula: C4H11N3O·2HCl. Mole weight: 190.07. Purity: >99.0%(T). Catalog: APB5787713. |  |
| Girard's Reagent P | Girards reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents. Group: Biochemicals. Alternative Names: 1- (Carboxymethyl) pyridinium Chloride Hydrazide; 1-(2-Hydrazino-2-oxoethyl)pyridinium Chloride; Girard-P Reagent; Girards P Reagent; Pyridinioaceto hydrazide Chloride. Grades: Highly Purified. CAS No. 1126-58-5. Pack Sizes: 5g, 10g, 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |
| Girard's Reagent P | Girard's Reagent P. Uses: For analytical and research use. Alternative Names: 1-(Hydrazinocarbonylmethyl)pyridinium Chloride; (1-Pyridinio)acetohydrazide Chloride. CAS No. 1126-58-5. Molecular formula: C7H10ClN3O. Mole weight: 187.63. Purity: >95.0%(T). Catalog: APB1126585. | |
| Girard's Reagent T | Girard's Reagent T. Uses: For analytical and research use. Alternative Names: Betaine Hydrazide Hydrochloride; (Hydrazinocarbonylmethyl)trimethylammonium Chloride; Trimethylacetohydrazideammonium Chloride. CAS No. 123-46-6. Molecular formula: C5H14ClN3O. Mole weight: 167.64. Purity: >98.0%(T). Catalog: APB123466. | |
| Girards Reagent T | Girards Reagent T. CAS No: 123-46-6 |  Sarchem Laboratories New Jersey NJ |
| Giredestrant | Giredestrant (GDC-9545), a non-steroidal estrogen receptor (ER) ligand, is an orally active and selective ER antagonist. Giredestrant potently competes with Estradiol for binding and induces a conformational change within the ER ligand binding domain. Giredestrant has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-9545; RG6171. CAS No. 1953133-47-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109176. | |
| Giredestrant | Giredestrant is an orally active and selective ER antagonist with anti-tumor activity. Synonyms: GDC-9545. Grade: ≥98% by HPLC. CAS No. 1953133-47-5. Molecular formula: C27H31F5N4O. Mole weight: 522.6. | |
| Giredestrant tartrate | Giredestrant tartrate is an orally active and selective ER antagonist with anti-tumor activity. Synonyms: GDC-9545 tartrate; (2R,3R)-2,3-Dihydroxysuccinic acid 3-[(1R,3R)-1-(2,6-difluoro-4-{[1-(3-fluoropropyl)-3-azetidinyl]amino}phenyl)-3-methyl-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl]-2,2-difluoro-1-propanol (1:1); Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (1R,3R)-1-[2,6-difluoro-4-[[1-(3-fluoropropyl)-3-azetidinyl]amino]phenyl]-β,β-difluoro-1,3,4,9-tetrahydro-3-methyl-2H-pyrido[3,4-b]indole-2-propanol (1:1); Estrogen receptor antagonist 1. Grade: ≥95%. CAS No. 2407529-33-1. Molecular formula: C31H37F5N4O7. Mole weight: 672.64. | |
| Girentuximab | Girentuximab is a chimeric monoclonal antibody that binds to carbonic anhydrase IX (CAIX), a cell-surface glycoprotein expressed on clear-cell RCC but not on normal kidney cells. Synonyms: G250; cG250. CAS No. 916138-87-9. | |
| Girentuximab | Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: G250; cG250. CAS No. 916138-87-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99023. | |
| girinimbine | girinimbine. Alternative Names: 3,11-Dihydro-3,3,5-trimethylpyrano[3,2-a]carbazole. CAS No. 23095-44-5. Purity: 95%+. Product ID: ACM23095445-1. Molecular formula: C18H17NO. Mole weight: 263.3. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Girinimbine | Girinimbine is a natural compound which can be isolated from Clausena vestita, Murraya euchrestifolia, etc. Synonyms: 3,11-Dihydro-3,3,5-trimethyl-Pyrano(3,2-a)carbazole; Pyrano(3,2-a)carbazole, 3,11-dihydro-3,3,5-trimethyl-. Grade: 98%. CAS No. 23095-44-5. Molecular formula: C18H17NO. Mole weight: 263.33. | |
| Girinimbine | Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Girinimbin. CAS No. 23095-44-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9488. | |
| Giripladib | Giripladib is a Phospholipase A2 inhibitor. Treatment with Giripladib attenuated radiation induced increases of phospho-ERK and phospho-Akt in endothelial cells. Giripladib in combination with irradiation significantly reduced migration and proliferation in endothelial cells and induced cell death and attenuated invasion by tumor cells. Uses: Antitumor. Synonyms: PLA-695; PLA 695; PLA695; Giripladib; 4-[3-[5-Chloro-1-(diphenylmethyl)-2-[2-[[[[2-(trifluoromethyl)phenyl]methyl]sulfonyl]amino]ethyl]-1H-indol-3-yl]propyl]benzoic Acid; 4-(3-[5-Chloro-1-(diphenylmethyl)-2-[2-(((2-(trifluoromethyl)benzyl)sulfonyl)amino)ethyl]-1H-indole-3-yl]propyl)benzoic Acid; PLA 695. Grade: 98%. CAS No. 865200-20-0. Molecular formula: C41H36ClF3N2O4S. Mole weight: 745.25. | |
| Giripladib | Giripladib inhibits cytosolic phospholipase A2 (cPLA2) which in turn radiosensitizes tumors in lung cancer animal models. Group: Biochemicals. Grades: Highly Purified. CAS No. 865200-20-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C41H36ClF3N2O4S, Molecular Weight: 745.25. US Biological Life Sciences. | Worldwide |
| Giripladib | Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PLA-695. CAS No. 865200-20-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-14952. | |
| Girolline | It is produced by the strain of Pseudaxinyssa cantharella. It can inhibit protein biosynthesis and has anti-tumor effect. Synonyms: Giracodazole; Girodazole; Giracodazolum; (alphaS)-2-Amino-alpha-((1S)-2-amino-1-chloroethyl)imidazole-4-methanol; (1S,2S)-1-(2-Amino-5-imidazolyl)-2-chloro-3-amino-1-propanol. Grade: 95%. CAS No. 110883-46-0. Molecular formula: C6H11ClN4O. Mole weight: 190.63. | |
| Gisadenafil | Gisadenafi is a potent PDE5 inhibitor (IC50 = 1.23 nM). Uses: A potent pde5 inhibitor. Synonyms: UK-369003; UK-369,003; 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine. Grade: ≥98%. CAS No. 334826-98-1. Molecular formula: C23H33N7O5S. Mole weight: 519.62. | |
| Gisadenafil besylate | Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM) with >100-fold selectivity for PDE5 over PDE6. Gisadenafil besylate inhibits the breakdown of cyclic phosphodiester secondary messenger molecules. Synonyms: UK 369003; UK369003; UK-369003; 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate. Grade: ≥99% by HPLC. CAS No. 334827-98-4. Molecular formula: C23H33N7O5S.C6H6O3S. Mole weight: 677.79. | |
| Gisadenafil Besylate | Gisadenafil Besylate. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one Benzenesulfonate; 1-[[6-Ethoxy-5-[3-ethyl-4,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridinyl]sulfonyl]-4-ethylpiperazine Monobenzenesulfonate; UK 369003-26. Grades: Highly Purified. CAS No. 334827-98-4. Pack Sizes: 10mg. Molecular Formula: C29H39N7O8S2, Molecular Weight: 677.79. US Biological Life Sciences. | Worldwide |
| GIT 27 | GIT 27. Group: Biochemicals. Grades: Purified. CAS No. 6501-72-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GIT 27 | GIT 27 is an orally active immunomodulatory agent. It inhibits TNF-α secretion via interference of macrophage TLR4 and TLR 2/6 signaling pathway. Synonyms: 5-Dihydro-3-phenyl-5-isoxazoleacetic acid; (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid; 3-phenyl-4,5-dihydro-5-isoxazole acetic acid; VGX-1027; VGX 1027; VGX1027; GIT 27; GIT-27; GIT27. CAS No. 6501-72-0. Molecular formula: C11H11NO3. Mole weight: 205.21. | |
| Gitogenin | Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 511-96-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2574. | |
| Gitogenin | Gitogenin. Group: Biochemicals. Alternative Names: (2alpha,3 β,5alpha,25R)-Spirostan-2,3-diol; Digine. Grades: Plant Grade. CAS No. 511-96-6. Pack Sizes: 20mg. Molecular Formula: C27H44O4, Molecular Weight: 432.636. US Biological Life Sciences. | Worldwide |
| Gitoxin | Gitoxin. Group: Biochemicals. Alternative Names: Gitoxigenin 3-O-tridigitoxoside; Anhydrogitalin. Grades: Highly Purified. CAS No. 4562-36-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C41H64O14. US Biological Life Sciences. | Worldwide |
| Gitoxin | Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na+/K+-ATPase inhibitor, with an IC50 of 1.18e-6 M against the porcine high-affinity subtype and an IC50 of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4562-36-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136933. | |
| Gitoxin | Gitoxin acts as an inhibitor of the Na+/K+-ATPase, interfering with ATPase activity and used in cancer treatment as a growth inhibitor. Synonyms: Anhydrogitalin; Pseudodigitoxin; Bigitalin; Gitoxigenin 3-O-tridigitoxoside; NSC 95099. CAS No. 4562-36-1. Molecular formula: C41H64O14. Mole weight: 780.94. | |
| GIV3727 | GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 957136-80-0. Pack Sizes: 1 mg (50.43 mM * 100 μL in Methanol); 5 mg (50.43 mM * 500 μL in Methanol); 10 mg (50.43 mM * 1 mL in Methanol). Product ID: HY-124956. | |
| Givastomig | Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TJ-CD4B; ABL111; TJ033721. CAS No. 2762499-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990742. | |
| Givescone ® | Givescone ®. CAS No. 57934-97-1. Kosher: Y. VIGON Item # 500893. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, rose carboxylate. |  America & Internationally |
| Givinostat | Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research. Givinostat can penetrate the blood-brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITF-2357. CAS No. 497833-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14842. | |
| Givinostat | Givinostat (INN) or gavinostat, aslo known as ITF2357, is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a hydroxamate used in the form of its hydrochloride. Givinostat is in numerous phase II clinical trials (including for relapsed leukemias and myelomas), and has been granted orphan drug designation in the European Union for the treatment of systemic juvenile idiopathic arthritis and polycythaemia vera. ITF2357 was discovered at Italfarmaco of Milan, Italy. It was patented in 1997 and first described in the scientific literature in 2005. Synonyms: Givinostat; gavinostat; ITF-2357; ITF 2357; ITF2357. CAS No. 497833-27-9. Molecular formula: C24H27N3O4. Mole weight: 421.497. | |
| Givinostat hydrochloride | Givinostat hydrochloride is the hydrochloride salt form of Givinostat. Givinostat, also called as GVS or ITF2357, a potent HDAC inhibitor for Maize HD2 (IC50= 10 nM), HD1-B (IC50= 7.5 nM nM) and HD1-A (IC50= 16 nM), has antiproliferative and proapoptotic. Uses: Histone deacetylase inhibitors. Synonyms: (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride; ITF2357; ITF-2357; ITF 2357; ITF2357 HCl; ITF2357 hydrochloride; Givinostat HCl gavinostat. CAS No. 199657-29-9. Molecular formula: C24H28ClN3O4. Mole weight: 457.95. | |
| Givinostat hydrochloride monohydrate | Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride monohydrate can penetrate the blood-brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITF-2357 hydrochloride monohydrate. CAS No. 732302-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14842B. | |
| Givinostat hydrochloride monohydrate | Givinostat, also known as ITF2357, is an orally active HDAC inhibitor (IC50= 198 and 157 nM for HDAC1 and HDAC3, respectively), with potential anti-inflammatory, anti-angiogenic, and antineoplastic properties. Uses: Histone deacetylase inhibitors. Synonyms: [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate; hydrate; hydrochloride; givinostat hydrochloride; ITF 2357; ITF2357; ITF-2357; ITF2357 HCl; ITF2357 hydrochloride. CAS No. 732302-99-7. Molecular formula: C24H27N3O4.HCl.H2O. Mole weight: 475.97. | |
| Givosiran | Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-AS1. CAS No. 1639325-43-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132610. | |
| Givosiran sodium | Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-AS1 sodium. CAS No. 1639325-44-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132610A. | |
| GJ103 | GJ103 Inhibitor. Uses: Scientific use. Product Category: T4251. CAS No. 1459687-96-7. |  |
| GJ-103 free acid | GJ-103 free acid. Alternative Names: GJ-103 free acid; GJ103; GJ 103; GJ-103. CAS No. 1459687-89-8. Purity: >98%. Product ID: ACM1459687898. Molecular formula: C16H14N4O3S. Mole weight: 342.37. IUPAC Name: 2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid. Alfa Chemistry - ISO 9001:32057 Certified. | |
| GJ19 | GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with Kd values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3099808-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-174830. | |
| GK187 | GK187 is a highly potent and selective inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). Synonyms: 1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)-3-heptanone. Grade: ≥95%. CAS No. 1071001-50-7. Molecular formula: C14H15F5O2. Mole weight: 310.26. | |
| GK921 | GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 μM in cancer cell lines. Synonyms: GK921; GK-921; GK 921. Grade: >98%. CAS No. 1025015-40-0. Molecular formula: C21H20N4O. Mole weight: 344.41. | |
| GK921 | GK921 is a transglutaminase 2 (TGase) inhibitor with an IC50 of 7.71 μM for human recombinant TGase 2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1025015-40-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12337. | |
| GK921 | GK921 Inhibitor. Uses: Scientific use. Product Category: T3968. CAS No. 1025015-40-0. | |
| GKA 50 | GKA 50. Group: Biochemicals. Grades: Purified. CAS No. 851884-87-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| GKA 50 | GKA 50 is a potent glucokinase activator (EC50 = 33 nM). It causes a decrease in plasma glucose levels in diabetic rats and an increase of insulin release from mouse islets of Langerhans. GKA 50 was shown to promote proliferation and prevent apoptosis in rat pancreatic insulinoma-1 beta cell. Synonyms: GKA 50; GKA50; GKA-50; 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid. Grade: ≥98% by HPLC. CAS No. 851884-87-2. Molecular formula: C26H28N2O6. Mole weight: 464.51. | |
| GKI-1 | GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2444764-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100521. | |
| GKK1032B | GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. CAS No. 358375-11-8. Molecular formula: C32H39NO4. Mole weight: 501.67. | |
| GKT136901 | GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 955272-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101499. | |
| GKT136901 hydrochloride | GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254507-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101499A. | |
| GKT137831 | GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs. Synonyms: GKT137831; GKT-137831; GKT 137831; GTK831; GTK-831; GTK 831. Grade: >98%. CAS No. 1218942-37-0. Molecular formula: C21H19ClN4O2. Mole weight: 394.85. | |
| GL0388 | GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC50s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2886772-68-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132173. | |
| GL0388 | GL0388 is a Bax activator, which can lead to Bax insertion into mitochondrial membrane and induce Bax mediated apoptosis. GL0388 has anti-proliferative activity against various cancer cells with IC50s of 0.299-1.57 μM. GL0388 inhibits the growth of breast cancer xenograft tumors in vivo. Synonyms: (E)-2-((3-((2-fluoro-9H-fluoren-9-ylidene)methyl)pyridin-2-yl)oxy)ethan-1-amine. Molecular formula: C21H17FN2O. Mole weight: 332.37. | |
| GL64 | GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 μM). GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 488801-10-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175232. | |
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