A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Giripladib inhibits cytosolic phospholipase A2 (cPLA2) which in turn radiosensitizes tumors in lung cancer animal models. Group: Biochemicals. Grades: Highly Purified. CAS No. 865200-20-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C41H36ClF3N2O4S, Molecular Weight: 745.25. US Biological Life Sciences.
Worldwide
Giripladib
Giripladib is a Phospholipase A2 inhibitor. Treatment with Giripladib attenuated radiation induced increases of phospho-ERK and phospho-Akt in endothelial cells. Giripladib in combination with irradiation significantly reduced migration and proliferation in endothelial cells and induced cell death and attenuated invasion by tumor cells. Uses: Antitumor. Synonyms: PLA-695; PLA 695; PLA695; Giripladib; 4-[3-[5-Chloro-1-(diphenylmethyl)-2-[2-[[[[2-(trifluoromethyl)phenyl]methyl]sulfonyl]amino]ethyl]-1H-indol-3-yl]propyl]benzoic Acid; 4-(3-[5-Chloro-1-(diphenylmethyl)-2-[2-(((2-(trifluoromethyl)benzyl)sulfonyl)amino)ethyl]-1H-indole-3-yl]propyl)benzoic Acid; PLA 695. Grade: 98%. CAS No. 865200-20-0. Molecular formula: C41H36ClF3N2O4S. Mole weight: 745.25.
Giripladib
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PLA-695. CAS No. 865200-20-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-14952.
A blood-brain barrier-permeable, non-toxic phenyl-pyrazolylurea compound that acts as a direct, potent, fast, and reversible activator of GIRK1 (G-protein activated inward-rectifying K+ channel containing subunit 1) containing channels (EC50 = 162, 914, and 887nM in Thallium influx assay for GIRK1/2, GIRK1/3, and GIRK1/4 expressed in HEK-293 cell lines). Its action does not require the presence of an activated Gi GPCR. Shown to be inactive towards GIRK2, GIRK2/3, Kir2.1, KV7.4 and GABAA, and weakly active against a panel of 61 other receptors, ion channels, enzymes, transporters, and proteins even at higher concentration (~10uM). Exhibits desirable pharmacokinetic properties with good solubility (17.5uM), predicted hepatic clearance (88 ml/min/kg), and Tmax of 640nM and 130nM in plasma and brain, respectively. Shown to reduce locomotor function and seizure frequency in electroshock- and chemically-induced murine epilepsy models (60mg/kg, i.p). Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O. US Biological Life Sciences.
Worldwide
Girolline
It is produced by the strain of Pseudaxinyssa cantharella. It can inhibit protein biosynthesis and has anti-tumor effect. Synonyms: Giracodazole; Girodazole; Giracodazolum; (alphaS)-2-Amino-alpha-((1S)-2-amino-1-chloroethyl)imidazole-4-methanol; (1S,2S)-1-(2-Amino-5-imidazolyl)-2-chloro-3-amino-1-propanol. Grade: 95%. CAS No. 110883-46-0. Molecular formula: C6H11ClN4O. Mole weight: 190.63.
Gisadenafil
Gisadenafi is a potent PDE5 inhibitor (IC50 = 1.23 nM). Uses: A potent pde5 inhibitor. Synonyms: UK-369003; UK-369,003; 1-{6-ethoxy-5-[3-ethyl-6,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridylsulfonyl}-4-ethylpiperazine. Grade: ≥98%. CAS No. 334826-98-1. Molecular formula: C23H33N7O5S. Mole weight: 519.62.
Gisadenafil besylate
Gisadenafil besylate is a potent PDE5 inhibitor (IC50 = 1.23 nM) with >100-fold selectivity for PDE5 over PDE6. Gisadenafil besylate inhibits the breakdown of cyclic phosphodiester secondary messenger molecules. Synonyms: UK 369003; UK369003; UK-369003; 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one benzenesulfonate. Grade: ≥99% by HPLC. CAS No. 334827-98-4. Molecular formula: C23H33N7O5S.C6H6O3S. Mole weight: 677.79.
Gisadenafil Besylate
Gisadenafil Besylate. Group: Biochemicals. Alternative Names: 5-[2-Ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]-3-pyridinyl]-3-ethyl-2,6-dihydro-2-(2-methoxyethyl)-7H-pyrazolo[4,3-d]pyrimidin-7-one Benzenesulfonate; 1-[[6-Ethoxy-5-[3-ethyl-4,7-dihydro-2-(2-methoxyethyl)-7-oxo-2H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-pyridinyl]sulfonyl]-4-ethylpiperazine Monobenzenesulfonate; UK 369003-26. Grades: Highly Purified. CAS No. 334827-98-4. Pack Sizes: 10mg. Molecular Formula: C29H39N7O8S2, Molecular Weight: 677.79. US Biological Life Sciences.
Worldwide
GIT 27
GIT 27. Group: Biochemicals. Grades: Purified. CAS No. 6501-72-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
GIT 27
GIT 27 is an orally active immunomodulatory agent. It inhibits TNF-α secretion via interference of macrophage TLR4 and TLR 2/6 signaling pathway. Synonyms: 5-Dihydro-3-phenyl-5-isoxazoleacetic acid; (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid; 3-phenyl-4,5-dihydro-5-isoxazole acetic acid; VGX-1027; VGX 1027; VGX1027; GIT 27; GIT-27; GIT27. CAS No. 6501-72-0. Molecular formula: C11H11NO3. Mole weight: 205.21.
Gitogenin
Gitogenin. Group: Biochemicals. Alternative Names: (2alpha,3 β,5alpha,25R)-Spirostan-2,3-diol; Digine. Grades: Plant Grade. CAS No. 511-96-6. Pack Sizes: 20mg. Molecular Formula: C27H44O4, Molecular Weight: 432.636. US Biological Life Sciences.
Worldwide
Gitogenin
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 511-96-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2574.
Gitoxin
Gitoxin. Group: Biochemicals. Alternative Names: Gitoxigenin 3-O-tridigitoxoside; Anhydrogitalin. Grades: Highly Purified. CAS No. 4562-36-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C41H64O14. US Biological Life Sciences.
Worldwide
Gitoxin
Gitoxin is a degradation metabolite of Digitoxin (HY-B1357) and a non-competitive Na+/K+-ATPase inhibitor, with an IC50 of 1.18e-6 M against the porcine high-affinity subtype and an IC50 of 2.85e-5 M against the porcine low-affinity subtype. Gitoxin regulates atrial contractility and rhythmicity. Gitoxin is applicable to research related to congestive heart failure[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4562-36-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136933.
Gitoxin
Gitoxin acts as an inhibitor of the Na+/K+-ATPase, interfering with ATPase activity and used in cancer treatment as a growth inhibitor. Synonyms: Anhydrogitalin; Pseudodigitoxin; Bigitalin; Gitoxigenin 3-O-tridigitoxoside; NSC 95099. CAS No. 4562-36-1. Molecular formula: C41H64O14. Mole weight: 780.94.
GIV3727
GIV3727 is a bitter taste receptor hTAS2R antagonist, which can inhibit the activation of hTAS2R31 by saccharin and acesulfame potassium, and can effectively reduce the bitter quality of food, beverage and medicine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 957136-80-0. Pack Sizes: 1 mg (50.43 mM * 100 μL in Methanol); 5 mg (50.43 mM * 500 μL in Methanol); 10 mg (50.43 mM * 1 mL in Methanol). Product ID: HY-124956.
Givastomig
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TJ-CD4B; ABL111; TJ033721. CAS No. 2762499-30-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990742.
Givescone ®
Givescone ®. CAS No. 57934-97-1. Kosher: Y. VIGON Item # 500893. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, rose carboxylate.
America & Internationally
Givinostat
Givinostat (INN) or gavinostat, aslo known as ITF2357, is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a hydroxamate used in the form of its hydrochloride. Givinostat is in numerous phase II clinical trials (including for relapsed leukemias and myelomas), and has been granted orphan drug designation in the European Union for the treatment of systemic juvenile idiopathic arthritis and polycythaemia vera. ITF2357 was discovered at Italfarmaco of Milan, Italy. It was patented in 1997 and first described in the scientific literature in 2005. Synonyms: Givinostat; gavinostat; ITF-2357; ITF 2357; ITF2357. CAS No. 497833-27-9. Molecular formula: C24H27N3O4. Mole weight: 421.497.
Givinostat
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research. Givinostat can penetrate the blood-brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITF-2357. CAS No. 497833-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14842.
Givinostat hydrochloride
Givinostat hydrochloride is the hydrochloride salt form of Givinostat. Givinostat, also called as GVS or ITF2357, a potent HDAC inhibitor for Maize HD2 (IC50= 10 nM), HD1-B (IC50= 7.5 nM nM) and HD1-A (IC50= 16 nM), has antiproliferative and proapoptotic. Uses: Histone deacetylase inhibitors. Synonyms: (6-((diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate hydrochloride; ITF2357; ITF-2357; ITF 2357; ITF2357 HCl; ITF2357 hydrochloride; Givinostat HCl gavinostat. CAS No. 199657-29-9. Molecular formula: C24H28ClN3O4. Mole weight: 457.95.
Givinostat hydrochloride monohydrate
Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat hydrochloride monohydrate can penetrate the blood-brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITF-2357 hydrochloride monohydrate. CAS No. 732302-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14842B.
Givinostat hydrochloride monohydrate
Givinostat, also known as ITF2357, is an orally active HDAC inhibitor (IC50= 198 and 157 nM for HDAC1 and HDAC3, respectively), with potential anti-inflammatory, anti-angiogenic, and antineoplastic properties. Uses: Histone deacetylase inhibitors. Synonyms: [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate; hydrate; hydrochloride; givinostat hydrochloride; ITF 2357; ITF2357; ITF-2357; ITF2357 HCl; ITF2357 hydrochloride. CAS No. 732302-99-7. Molecular formula: C24H27N3O4.HCl.H2O. Mole weight: 475.97.
Givosiran
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-AS1. CAS No. 1639325-43-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132610.
Givosiran sodium
Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-AS1 sodium. CAS No. 1639325-44-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132610A.
GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with Kd values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3099808-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-174830.
GK187
GK187 is a highly potent and selective inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). Synonyms: 1,1,1,2,2-pentafluoro-7-(4-methoxyphenyl)-3-heptanone. Grade: ≥95%. CAS No. 1071001-50-7. Molecular formula: C14H15F5O2. Mole weight: 310.26.
GK921
GK921 is a transglutaminase 2 (TGase) inhibitor with an IC50 of 7.71 μM for human recombinant TGase 2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1025015-40-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12337.
GK921
GK921 is a transglutaminase 2 (TGase 2) inhibitor with average GI50 of 0.9 μM in cancer cell lines. Synonyms: GK921; GK-921; GK 921. Grade: >98%. CAS No. 1025015-40-0. Molecular formula: C21H20N4O. Mole weight: 344.41.
GKA 50. Group: Biochemicals. Grades: Purified. CAS No. 851884-87-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
GKA 50
GKA 50 is a potent glucokinase activator (EC50 = 33 nM). It causes a decrease in plasma glucose levels in diabetic rats and an increase of insulin release from mouse islets of Langerhans. GKA 50 was shown to promote proliferation and prevent apoptosis in rat pancreatic insulinoma-1 beta cell. Synonyms: GKA 50; GKA50; GKA-50; 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid. Grade: ≥98% by HPLC. CAS No. 851884-87-2. Molecular formula: C26H28N2O6. Mole weight: 464.51.
GKI-1
GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 μM against hGWLFL and hGWL-KinDom, respectively. GKI-1 robustly inhibits ROCK1 with an IC50 of 11 μM, but only weakly affected PKA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2444764-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100521.
GKK1032B
GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. CAS No. 358375-11-8. Molecular formula: C32H39NO4. Mole weight: 501.67.
GKT136901
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 955272-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101499.
GKT136901 hydrochloride
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254507-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101499A.
GKT137831
GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs. Synonyms: GKT137831; GKT-137831; GKT 137831; GTK831; GTK-831; GTK 831. Grade: >98%. CAS No. 1218942-37-0. Molecular formula: C21H19ClN4O2. Mole weight: 394.85.
GL0388
GL0388 is a Bax activator, which can lead to Bax insertion into mitochondrial membrane and induce Bax mediated apoptosis. GL0388 has anti-proliferative activity against various cancer cells with IC50s of 0.299-1.57 μM. GL0388 inhibits the growth of breast cancer xenograft tumors in vivo. Synonyms: (E)-2-((3-((2-fluoro-9H-fluoren-9-ylidene)methyl)pyridin-2-yl)oxy)ethan-1-amine. Molecular formula: C21H17FN2O. Mole weight: 332.37.
GL0388
GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC50s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis. GL0388 suppresses breast cancer xenograft tumor growth in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2886772-68-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132173.
GL64
GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 μM). GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 488801-10-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175232.
Glabralide A
Glabralide A is a kind of a unique skeleton of the chalcone-coupled monoterpenoid. It has a bicyclo [2.2.2] octene core unit with five chiral centers. Synonyms: Glabralide A; 1969289-10-8; B0005-267493. Grade: 97.0%. CAS No. 1969289-10-8. Molecular formula: C27H32O5. Mole weight: 436.00.
Glabralide B
Glabralide B is an enchanting natural compound, manifesting an impeccable amalgamation of anti-inflammatory and antioxidant effects. Synonyms: Glabralide B; 2170388-84-6; AKOS040760805. Grade: 98.0%. CAS No. 2170388-84-6. Molecular formula: C21H26O3. Mole weight: 326.436.
Glabralide C
Glabralide C, an organic compound derived from the Astragalus glabrescens blossoms, has been shown to exhibit neuroprotection and could be a promising treatment for neurodegenerative disorders like Alzheimer's. Synonyms: Glabralide C; 2170388-85-7. Grade: 96.0%. CAS No. 2170388-85-7. Molecular formula: C29H40O4. Mole weight: 452.634.
Glabranin
Glabranin is a natural flavonoid isolated from the roots of Glycyrrhiza uralensis Fisch. Synonyms: (2S)-2,3-Dihydro-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-2-phenyl-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (2S)-; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-(3-methyl-2-butenyl)-2-phenyl-, (S)-; Glabranin (flavonoid); Glabranine; 8-Prenylpinocembrin; 8-Dimethylallylpinocembrin. Grade: >98%. CAS No. 41983-91-9. Molecular formula: C20H20O4. Mole weight: 324.37.
Glabratine
Glabratine is a glucoalkaloid isolated from Uncaria glabrata. Grade: 97.5%. CAS No. 142750-47-8. Molecular formula: C27H34N2O9. Mole weight: 530.575.
Glabredelphinine
Glabredelphinine, a naturally occurring substance, has garnered attention for its remarkable efficacy in inducing apoptosis in tumors, thus displaying its potent anti-tumor activity. Furthermore, it has exhibited potential therapeutic benefits in the treatment of Alzheimer's disease by impeding acetylcholinesterase activity. Through its multifaceted mechanisms, Glabredelphinine represents an intriguing candidate for further exploration within both oncological and neurological research domains. Synonyms: Glabredelphinine; 132160-37-3; (3R,4S,5S,6S,8R,13R,16S,17R,18S)-11-ethyl-6-methoxy-13-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadec-14-ene-4,8,9,16,18-pentol(2R,3R,4S,5S,6S,8R,13R,16S,17R,18S)-11-ethyl-6-methoxy-13-methyl-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadec-14-ene-4,8,9,16,18-pentol. Grade: 97.5%. CAS No. 132160-37-3. Molecular formula: C22H33NO6. Mole weight: 407.507.
Glabrescione B
Glabrescione B is the first compound to bind the Hedgehog (Hh) modulator Gli1 and impair its activity by interfering with Gli1-DNA interaction. It inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells. Synonyms: 5,7-Dimethoxy-3',4'-diprenyloxyisoflavone; 4H-1-Benzopyran-4-one, 3-[3,4-bis[(3-methyl-2-buten-1-yl)oxy]phenyl]-5,7-dimethoxy-. Grade: ≥98%. CAS No. 65893-94-9. Molecular formula: C27H30O6. Mole weight: 450.52.
Glabrescione B
Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65893-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122590.
Glabrescone C
Glabrescone C has strong anti-inflammatory activity by directly binding to IKKα/β. Synonyms: (3aR,4R,6aR,9S,9aS,9bS)-6-formyl-9-hydroxy-9-(hydroxymethyl)-3-methylene-2-oxo-2,3,3a,4,6a,7,8,9,9a,9b-decahydroazuleno[4,5-b]furan-4-yl methacrylate. CAS No. 2757214-13-2. Molecular formula: C19H22O7. Mole weight: 362.37.
Glabridin
Glabridin. Group: Biochemicals. Alternative Names: 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]-1,3-benzenediol. Grades: Highly Purified. CAS No. 59870-68-7. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C20H20O4. US Biological Life Sciences.
Worldwide
Glabridin
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59870-68-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0393.
Glabrol
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59870-65-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N4193.
Glabrolide
Glabrolide is a triterpenoid β-secretase 1 (BACE-1) inhibitor derived from Glycyrrhiza uralensis Fisch. Synonyms: 3β,22β-Dihydroxy-11-oxoolean-12-en-30-oic acid γ-lactone; Olean-12-en-29-oic acid, 3,22-dihydroxy-11-oxo-, gamma-lactone, (3beta,20beta,22beta)-. Grade: ≥95%. CAS No. 10401-33-9. Molecular formula: C30H44O4. Mole weight: 468.67.
Glabrone
Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60008-02-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4194.
Glacial acetic acid
Glacial acetic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 64-19-7. Pack Sizes: 1kg, 2kg, 5kg, 10kg, 25kg. Molecular Formula: C2H4O2. US Biological Life Sciences.
Worldwide
Glacial Acetic Acid
Glacial Acetic Acid. Group: Industrial Chemicals. Purity: Purity: 99.85% Min. CAS No. 64-19-7. Molecular formula: Molecular formula: CH3COOH. UN no: 2789.
Glacial Acetic Acid IP/BP/USP
Glacial Acetic Acid IP/BP/USP. CAS No. 64-19-7. Molecular formula: C2H4O2.
It is produced by the strain of Penicillum gladioli. It has the antifungal activity of Absidia glauca Hagem, garlic spores, Byssochlamys fulva, Trichophyton mentagrophytes, Corpuscular falciparum. Synonyms: Isogladiolic acid; Gladiolsaeure; 4-methoxy-5-methyl-o-phthaldehyde; puberulonic acid; 2,3-Diformyl-6-methoxy-5-methyl-benzoesaeure. CAS No. 478-05-7. Molecular formula: C11H10O5. Mole weight: 222.19.
Glafenic acid
Glafenic acid. Group: Biochemicals. Alternative Names: 2-[ (7-Chloro-4-quinolinyl) amino]benzoic acid; N-(7-Chloro-4-quinolyl)anthranilic acid; (+)-Glafenic acid. Grades: Highly Purified. CAS No. 10440-42-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C16H11ClN2O2. US Biological Life Sciences.
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Glafenine
Glafenine. Group: Biochemicals. Alternative Names: 2-[ (7-Chloro-4-quinolinyl) amino]benzoic acid 2,3-dihydroxypropyl ester; 1-[N- (7-Chloro-4-quinolyl) anthranilate]glycerol; N-(7-Chloro-4-quinolyl)anthranilic acid 2,3-dihydroxypropyl ester. Grades: Highly Purified. CAS No. 3820-67-5. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C19H17ClN2O4. US Biological Life Sciences.
Worldwide
Glafenine
Glafenine is a non-steroidal analgesic agent, shows significant antiinflammatory activity. Uses: Wdely used for the treatment of pains of various origins. Synonyms: 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate; 1-Glyceryl N-(7-chloro-4-quinolyl)anthranilate. Grade: ≥98%. CAS No. 3820-67-5. Molecular formula: C19H17ClN2O4. Mole weight: 372.80.
Glafenine
Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glafenin. CAS No. 3820-67-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-B1153.
Glafenine hydrochloride
Glafenine hydrochloride, an anthranilic acid derivative, is a non-narcotic analgesic and non-steroidal anti-inflammatory drug. It is an ABCG2 inhibitor (IC50 = 3.2 μM). Synonyms: 2,3-dihydroxypropyl 2-[(7-chloroquinolin-4-yl)amino]benzoate; hydrochloride; Glafenine (hydrochloride). CAS No. 65513-72-6. Molecular formula: C19H18Cl2N2O4. Mole weight: 409.26.
Glafenine (Standard)
Glafenine (Standard) is the analytical standard of Glafenine. This product is intended for research and analytical applications. Glafenine (Glafenin) is a non-selective, non-steroidal anti-inflammatory drug-based COX-1/COX-2 inhibitor. Glafenine exerts anti-inflammatory, anti-proliferative and anti-cell migration effects by inhibiting the arachidonic acid metabolic pathway and reducing prostaglandin synthesis. Glafenine can induce cell cycle arrest in vascular smooth muscle cells and endothelial cells and reduce the synthesis of the extracellular matrix protein Tenascin. Glafenine can be used in the research of inflammatory-related diseases, vascular restenosis and cystic fibrosis (CF)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glafenin (Standard). CAS No. 3820-67-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1153R.