A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-04449913. CAS No. 1095173-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16391.
Glasdegib
Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduction. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model. Synonyms: PF-04449913; PF 04449913; 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea. Grade: >98%. CAS No. 1095173-27-5. Molecular formula: C21H22N6O. Mole weight: 374.44.
an immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS). Category: Active pharmaceutical ingredients. CAS No. 28704-27-0. Product ID: API28704270. Molecular formula: C23H41N5O11. Mole weight: 563.599.
Glatiramer acetate
Glatiramer acetate is an immunomodulator drug currently used to treat multiple sclerosis. It is a random polymer of four amino acids found in myelin basic protein, namely L-glutamic acid, L-lysine, L-alanine, and L-tyrosine. Uses: Multiple sclerosis (ms) is a chronic autoimmune illness that affects the central nervous system. glatiramer acetate is one medicine used to treat ms. glatiramer acetate is primarily used to treat multiple sclerosis (ms), but because of its immunomodulatory qualities and capacity to control inflammatory reactions, scientists have also looked at the possibility of using it in the drug discovery proc. Synonyms: Copaxone; Copolymer 1; Copolymer-1. CAS No. 147245-92-9. Molecular formula: C25H45N5O13. Mole weight: 623.657.
Glatiramer acetate
Glatiramer acetate, a synthetic analogue of myelin basic protein and an immunomodulating agent, inhibits Experimental autoimmune encephalomyelitis (EAE), and can be used for the research of multiple sclerosis. Glatiramer acetate exhibits strong and promiscuous binding to MHC molecules and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 147245-92-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109520.
Glatiramer Acetate
Glatiramer acetate is a random basic synthetic copolymer of L-alanine, L-lysine, l-glutamic acid and L-tyrosine in a molar ratio of 6:1.9:4.7:1. Glatiramer acetate is an immunomodulator used in treatment of multiple sclerosis. A representative lot had an average molecular weight of 4600 amu. Group: Biochemicals. Alternative Names: L-Alanine polymer with L-Glutamic Acid L-Lysine L-Tyrosine Acetate ; L-Tyrosine polymer with L-Alanine L-Glutamic Acid L-Lysine Acetate; 511: PN: WO2010103292 PAGE: 64 claimed sequence; Cop 1; Copaxone; Copolymer 1; L-Glutamic Acid peptide with L-Alanine L-Lysine L-Tyrosine Acetate Salt; Protiramer; TV 5010. Grades: Highly Purified. CAS No. 147245-92-9. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C?H??NO?; C? H??N?O?; C?H?NO?; C?H?NO?. US Biological Life Sciences.
Worldwide
Glatiramer-d7
Glatiramer-d7 is a labelled Glatiramer. Glatiramer acetate is an immunomodulator drug used for multiple sclerosis. Grade: > 95%. Molecular formula: C25H38N5O13D7. Mole weight: 630.70.
Glaucine hydrobromide
Glaucine hydrobromide. CAS No. 5996-6-5. Product ID: ACM1496191. Alfa Chemistry - ISO 9001:32057 Certified.
Glaucocalyxin A
Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. Uses: Antiplatelet/antithrombotic. Synonyms: LeukaMenin F; Wangzaozin B; Leucamenin F. Grade: >98%. CAS No. 79498-31-0. Molecular formula: C20H28O4. Mole weight: 332.43.
Glaucocalyxin A
Glaucocalyxin A. Group: Biochemicals. Alternative Names: Leukamenin F; Wangzaozin B. Grades: Plant Grade. CAS No. 79498-31-0. Pack Sizes: 10mg. Molecular Formula: C20H28O4, Molecular Weight: 332.434. US Biological Life Sciences.
Worldwide
Glaucocalyxin A Liposome
Glaucocalyxin A is a diterpenoid component that has strong antitumor activity against different leukemia cell lines. This product is a pre-formulated liposome with glaucocalyxin A. It is only for research purposes. Group: Drug-loaded liposome.
The enzyme is involved in the biosynthesis of the exopolysaccharide xanthan. Group: Enzymes. Synonyms: GumI. Enzyme Commission Number: EC 2.4.1.251. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2481; GlcA-β-(1?2)-D-Man-α-(1?3)-D-Glc-β-(1?4)-D-Glc-α-1-diphospho-ditrans,octacis-undecaprenol 4-β-mannosyltransferase; EC 2.4.1.251; GumI. Cat No: EXWM-2481.
The enzyme is involved in the biosynthesis of the exopolysaccharide xanthan.
GlcNAc-1-phosphate uridyltransferase from Campylobacter jejuni, Recombinant
N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU), a bifunctional enzyme exclusive to prokaryotes, belongs to the family of sugar nucleotidyltransferases (SNTs). The enzyme binds GlcNAc-1-P and UTP, and catalyzes a uridyltransfer reaction to synthesize UDP-GlcNAc, an important precursor for cell-wall biosynthesis. Group: Enzymes. Synonyms: N-Acetylglucosamine-1-phosphate uridyltransferase; GlmU; EC 2.3.1.157. Enzyme Commission Number: EC 2.3.1.157. Purity: min 95% by SDS-PAGE. GlcNAc1-phosphate uridyltransferase. Source: E. coli. Species: Campylobacter jejuni. N-Acetylglucosamine-1-phosphate uridyltransferase; GlmU; EC 2.3.1.157; GlcNAc1-P Uridyltransferase. Cat No: NATE-1492.
GlcNAc1-phosphate uridyltransferase from E. coli K-12, Recombinant
N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU), a bifunctional enzyme exclusive to prokaryotes, belongs to the family of sugar nucleotidyltransferases (SNTs). The enzyme binds GlcNAc-1-P and UTP, and catalyzes a uridyltransfer reaction to synthesize UDP-GlcNAc, an important precursor for cell-wall biosynthesis. Group: Enzymes. Synonyms: N-Acetylglucosamine-1-phosphate uridyltransferase; GlmU; EC 2.3.1.157. Enzyme Commission Number: EC 2.3.1.157. Purity: min 95% by SDS-PAGE. GlcNAc1-phosphate uridyltransferase. Mole weight: 25 kDa. Source: E. coli. Species: E. coli K-12. N-Acetylglucosamine-1-phosphate uridyltransferase; GlmU; EC 2.3.1.157; GlcNAc1-P Uridyltransferase. Cat No: NATE-1482.
GlcNAc-1-phosphate uridyltransferase from Human, Recombinant
N-Acetylglucosamine-1-phosphate uridyltransferase (GlmU), a bifunctional enzyme exclusive to prokaryotes, belongs to the family of sugar nucleotidyltransferases (SNTs). The enzyme binds GlcNAc-1-P and UTP, and catalyzes a uridyltransfer reaction to synthesize UDP-GlcNAc, an important precursor for cell-wall biosynthesis. Group: Enzymes. Synonyms: N-Acetylglucosamine-1-phosphate uridyltransferase; GlmU; EC 2.3.1.157. Enzyme Commission Number: EC 2.3.1.157. CAS No. 9023-06-7;9031-91-8. Purity: min 95% by SDS-PAGE. GlcNAc1-phosphate uridyltransferase. Source: E. coli. Species: Human. N-Acetylglucosamine-1-phosphate uridyltransferase; GlmU; EC 2.3.1.157; GlcNAc1-P Uridyltransferase. Cat No: NATE-1500.
GlcNAc-MurNAc
GlcNAc-MurNAc, a disaccharide, is a TLR4 agonist with a Kd of 383 μM for murine TLR4. GlcNAc-MurNAc directly binds to TLR4 and activates its downstream NF-κB and IRF pathways. GlcNAc-MurNAc improves Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis in mice through a TLR4-dependent mechanism. GlcNAc-MurNAc can be used for the study of inflammatory bowel disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 41137-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-175222.
GlcNPhth[346Ac]b(1-3)Gal[246Bn]-b-MP
GlcNPhth[346Ac]b(1-3)Gal[246Bn]-b-MP is an innovative compound, finding its applications in studying aberrant cellular proliferation. By selectively antagonizing intricate molecular cascades implicated in the advancement of neoplastic conditions, it emerges as a potent inhibitory compound. Synonyms: 4-Methoxyphenyl 3-O-(3,4,6-Tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-2,4,6-tri-O-benzyl-b-D-galactopyranoside. CAS No. 1820575-44-7. Molecular formula: C54H55NO16. Mole weight: 974.01.
glecaprevir
Glecaprevir is a suppressive agent of hepatitis C virus (HCV). Glecaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 4.09 μM. Uses: The treatment of hepatitis c virus (hcv) infection. Synonyms: ABT 493; (3aR,7S,10S,12R,21E,24aR)-7-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-20,20-difluoro-5,8-dioxo-2,3,3a,5,6,7,8,11,12,20,23,24a-dodecahydro-1H,10H-9,12-methanocyclopenta[18,19][1,10,17,3,6]trioxadiazacyclononadecino[11,12-b]quinoxaline-10-carboxamide. Grade: 98%. CAS No. 1365970-03-1. Molecular formula: C38H46F4N6O9S. Mole weight: 838.87.
Glecaprevir
Glecaprevir is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. Glecaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 4.09 μM[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-493. CAS No. 1365970-03-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17634.
Glecaprevir
Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM). Category: Active pharmaceutical ingredients. CAS No. 1365970-03-1. Product ID: API1365970031. Molecular formula: C38H46F4N6O9S. Mole weight: 838.87.
Glecirasib
Glecirasib (Compound 1-2; JAB-21822) is an orally active and potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. Glecirasib has the potential for the research of KRAS G12C-mediated cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JAB-21822; KRAS G12C inhibitor 36. CAS No. 2657613-87-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143589.
Glemanserin
Glemanserin (MDL11939) is a potent and selective antagonist for serotonin receptor 5-HT2A (Ki=2.89, 0.54 and 2.5 nM for rat 5-HT2A, rabbit 5-HT2A and human 5-HT2A, respectively)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MDL11939. CAS No. 107703-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101250.
Glembatumumab
Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1020264-78-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99205.
Glembatumumab
Glembatumumab is a human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be linked to monomethyl auristatin E (MMAE) to form Glembatumumab vedotin, an ADC for cancer therapy. Synonyms: Anti-GPNMB. CAS No. 1020264-78-1.
Glembatumumab vedotin
Glembatumumab vedotin (CDX-011) is an ADC comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CDX-011; CR011-vcMMAE. CAS No. 1182215-65-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141604.
Glenzocimab
Glenzocimab is an antibody fragment that inhibits the action of platelet glycoprotein VI (GPVI). Glenzocimab has the potential therapeutic effect on acute ischaemic stroke. Synonyms: ACT-017; ACT 017; ACT017. Grade: 95%. CAS No. 2101829-58-5.
Glepaglutide
Glepaglutide (ZP1848), a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide reduces faecal output and increases intestinal absorption. Glepaglutide alleviates small intestinal inflammation. Glepaglutide can be used in the research of inflammatory bowel disease (IBD) and Crohns disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZP1848. CAS No. 914009-86-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P2221.
Glepaglutide
Glepaglutide, a long-acting GLP-2 analogue, is a potent GLP-2R agonist. Glepaglutide reduces faecal output and increases intestinal absorption. Glepaglutide alleviates small intestinal inflammation. Glepaglutide can be used in the research of inflammatory bowel disease (IBD) and Crohn's disease. Synonyms: ZP1848. CAS No. 914009-86-2. Molecular formula: C197H325N53O55. Mole weight: 4316.08.
Glesatinib
Glasatinib (MGCD265) is a dual MET/SMO inhibitor. Glesatinib is a small molecule, multi-target tyrosine kinase inhibitor with potential anti-tumor activity, which can antagonize P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC). Synonyms: MGCD-265; MGCD 265; MGCD265. Grade: ≥98% by HPLC. CAS No. 936694-12-1. Molecular formula: C31H27F2N5O3S2. Mole weight: 619.7.
Glesatinib hydrochloride
The hydrochloride salt form of Glesatinib, an inhibitor of tyrosine kinase, could be effectively targeting tumors that are driving to grow through MET and AXL receptor. It seems to be more common in non-small cell lung cancer and it is still under Phase I. Uses: The hydrochloride salt form of glesatinib could be effectively targeting tumors that are driving to grow through met and axl receptor. Synonyms: MGCD265 hydrochloride; MGCD-265 hydrochloride; MGCD 265 hydrochloride. Grade: 98%. CAS No. 1123838-51-6. Molecular formula: C31H27ClF2N5O3S2X. Mole weight: 655.16.
Glesatinib hydrochloride
Glesatinib hydrochloride (MGCD265 hydrochloride) is an orally active, potent MET/SMO dual inhibitor. Glesatinib hydrochloride, a tyrosine kinase inhibitor, antagonizes P-glycoprotein (P-gp) mediated multidrug resistance (MDR) in non-small cell lung cancer (NSCLC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGCD265 hydrochloride. CAS No. 2319837-80-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19642A.
GLGPNPCRKKCYKRDFLGR
It is a synthetic peptide. Grade: ≥98%. Molecular formula: C96H158N32O24S2. Mole weight: 2208.64.
Gliadin p31-43
Gliadin p31-43 is an undigested gliadin peptide. Gliadin p31-43 induces an innate immune response in the intestine and interferes with endocytic trafficking. Gliadin p31-43 can be used for celiac disease research[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 176326-01-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P3151.
Gliadorphin-7
Gliadorphin-7, an opioid peptide, is formed during the digestion of the gliadin component of the gluten protein. Elevated concentration of gliadorphin-7 due to inadequate proteolysis has been linked to autism, schizophrenia, and celiac disease. Synonyms: α/β-Gliadin (43-49); H-Tyr-Pro-Gln-Pro-Gln-Pro-Phe-OH; L-tyrosyl-L-prolyl-L-glutaminyl-L-prolyl-L-glutaminyl-L-prolyl-L-phenylalanine; alpha-gliadin (43-49); GD-7; Prolamin (43-49); Gluteomorphin; Gliadorphin. Grade: ≥95%. CAS No. 107936-65-2. Molecular formula: C43H57N9O11. Mole weight: 875.98.
Gliamilide
Gliamilide is a high-potency Sulfonated urea hypoglycemic agent. Uses: Gliamilide is used as a hypoglycemic agent. Synonyms: CP-27,634; CP 27,634; CP27,634; endo-1-((4-(2-(2-Methoxynicotinamido)ethyl)piperidino)sulfonyl)-3-(5-norbornen-2-ylmethyl)urea. Grade: 98%. CAS No. 51876-98-3. Molecular formula: C23H33N5O5S. Mole weight: 491.61.
Glibenclamide
Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glyburide. CAS No. 10238-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-15206.
Glibenclamide
Glibenclamide. Group: Biochemicals. Grades: Purified. CAS No. 10238-21-8. Pack Sizes: 100mg. US Biological Life Sciences.
Cell-permeable. An anti-diabetic agent. ATP-sensitive potassium channel (KATP) blocker. Inhibits KATP currents in the pancreatic beta cells causing an increase in intracellular Ca2+ and insulin secretion. Group: Biochemicals. Grades: Highly Purified. CAS No. 10238-21-8. Pack Sizes: 500mg, 1g. US Biological Life Sciences.
Worldwide
Glibenclamide-[d11]
Glibenclamide-[d11] is an isotopically labelled analog of Glibenclamide, which is a medication used to treat diabetes mellitus type 2. Synonyms: 5-Chloro-N-[2-[4-[[[(cyclohexylamino-d11)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide; 1-[4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonyl] -3-(cyclohexyl-d11)urea; glybenclamide (cyclohexylamine-d11). Grade: 98% by CP; 98% atom D. CAS No. 1189985-02-1. Molecular formula: C23H17D11ClN3O5S. Mole weight: 505.07.
Glibenclamide EP Impurity B
Glibenclamide EP Impurity B. Uses: For analytical and research use. Alternative Names: Glyburide USP Related Compound B; methyl (4-(2-(5-chloro-2-methoxybenzamido)ethyl)phenyl)sulfonylcarbamate. CAS No. 21165-77-5. Molecular formula: C18H19ClN2O6S. Mole weight: 426.87. Catalog: APB21165775.
Glibenclamide impurity 1
Glibenclamide impurity 1. Uses: For analytical and research use. CAS No. 2191-62-0. Molecular formula: C17H25N3O4S. Mole weight: 367.46. Catalog: APB2191620.
Glibenclamide impurity 10
Glibenclamide impurity 10. Uses: For analytical and research use. CAS No. 151890-69-6. Molecular formula: C19H21ClN2O6S. Mole weight: 440.9. Catalog: APB151890696.
Glibenclamide impurity 2
Glibenclamide impurity 2. Uses: For analytical and research use. Molecular formula: C16H16Cl2N2O4S. Mole weight: 403.27. Catalog: APB11302.
Glibenclamide impurity 3
Glibenclamide impurity 3. Uses: For analytical and research use. Molecular formula: C23H28ClN3O5S. Mole weight: 494. Catalog: APB11301.
Glibenclamide impurity 4
Glibenclamide impurity 4. Uses: For analytical and research use. Molecular formula: C23H28ClN3O5S. Mole weight: 494. Catalog: APB11306.
Glibenclamide impurity 5
Glibenclamide impurity 5. Uses: For analytical and research use. Molecular formula: C32H31Cl2N3O8S2. Mole weight: 720.63. Catalog: APB11305.
Glibenclamide impurity 6
Glibenclamide impurity 6. Uses: For analytical and research use. CAS No. 33924-49-1. Molecular formula: C16H16ClNO2. Mole weight: 289.76. Catalog: APB33924491.
Glibenclamide impurity 7
Glibenclamide impurity 7. Uses: For analytical and research use. Molecular formula: C24H22Cl2N2O6S. Mole weight: 537.41. Catalog: APB11303.
Glibenclamide impurity 8
Glibenclamide impurity 8. Uses: For analytical and research use. Molecular formula: C15H18ClNO4. Mole weight: 311.76. Catalog: APB11304.