A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Gum Karaya is a vegetable gum produced from the exudate of the sterculia trees. Gum Karaya is an acidic polysaccharide composed of galactose, rhamnose and galacturonic acid. It is used in food as a thickener and emulsifier, and as a laxative and denture binder. Alternative Names: E 416; Karaya gum; Gums, karaya; Gums, sterculia; Indian tragacanth gum; Inolaxol; Kadai gum; Kadaya gum; Karaya K 5; Karayacol; Katilo gum; Kullo gum; Lamegum; Mucara; Siltex gum; Sterculia BP; Sterculia gum; Tab gum. CAS No. 9000-36-6.
Gum Rosin
Gum Rosin and its derivatives can be used as microencapsulating materials, film forming agents, and binding agents in formulation of tablets. They are also used in the formulation of cosmetics and the bases of chewing gum. Gum Rosin extracts are also commonly used to treat burns. Group: Biochemicals. Grades: Highly Purified. CAS No. 8050-9-7. Pack Sizes: 10g, 25g. Molecular Formula: N/A, Molecular Weight: US Biological Life Sciences.
Worldwide
Gum Rosin
Gum Rosin. We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner.
US and Canada
GUM ROSIN
PALE-YELLOW-TO-AMBER FRAGMENTS OR POWDER WITH CHARACTERISTIC ODOUR. CAS No. 8050-9-7. Molecular formula: C20H30O2. Mole weight: 302.5g/mol. IUPAC Name: (4aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid. SMILES: CC(C)C1=CC2=CCC3C(C2CC1)(CCCC3(C)C(=O)O)C. InChI: InChI=1S/C20H30O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h7,12-13,16-17H,5-6,8-11H2,1-4H3,(H,21,22)/t16?,17?,19-,20?/m1/s1.
Gum Sandarac
Gum Sandarac
gum storax
gum storax. Alternative Names: STYRAX ESSENCE; STYRAX ESSENCE OLIFFAC; Asiaticstyrax; Gumstyraxhonduras; GumstyraxHonduraswhite; Liquidambarextractives; storax(balsam); Storax,balsam. CAS No. 8046-19-3.
Gum tragacanth
100g Pack Size. Group: Biochemicals, Carbohydrates, Flavours and Fragrance Materials. Formula: N/A. CAS No. 9000-65-1. Prepack ID 38835433-100g. See USA prepack pricing.
Gum Turpentine
Gum Turpentine. We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner.
US and Canada
Gunacin
It is produced by the strain of Ustilago sp. It is a quinone antibiotic. It has strong activity against gram-positive bacteria, negative bacteria and mycoplasma. Alternative Names: 2H-Naphtho(2,3-b)pyran-5,10-dione, 3,4-dihydro-4-(acetyloxy)-3,6-dihydroxy-8-methoxy-2-methyl-. Grades: 95%. CAS No. 73341-70-5. Molecular formula: C17H16O8. Mole weight: 348.33.
Gunagratinib
Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer[1]. Gunagratinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICP-192. CAS No. 2211082-53-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132817.
Guretolimod
Guretolimod is an agonist of Toll-like receptor 7 (TLR7) with potential immunostimulatory and antineoplastic activities. Alternative Names: Glycine, N-[[4-[[2-amino-4-[[(1S)-1-(2-hydroxyethyl)butyl]amino]-6-methyl-5-pyrimidinyl]methyl]-3-methoxyphenyl]methyl]-N-(2,2,2-trifluoroethyl)-; (S)-2-((4-((2-amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxybenzyl)(2,2,2-trifluoroethyl)amino)acetic acid. Grades: ≥90%. CAS No. 1488364-57-3. Molecular formula: C24H34F3N5O4. Mole weight: 513.55.
Gurjun Dark - Copaene
The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%). Uses: Fragrance. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-001. Olfactive Profile: Balsamic, woody, sweet, greasy, pepper. EC No: 232-444-8. Origin: Indonesia.
New Jersey
Gurjun Dark - Gurjunene
"The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%)". Uses: Fragrance. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-003. Olfactive Profile: Balsamic, woody, sweet. EC No: 232-444-8. Origin: Malaysia.
New Jersey
Gurjunene 85%+
"The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents". Uses: Fragrances, Cosmetics. Group: Plant Extracts. INCI Names: Gurjunene. Grades: INDUSTRIAL GRADE. CAS No. 489-40-7. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-005. Olfactive Profile: Balsamic, woody, sweet. EC No: 207-695-1. Origin: Malaysia.
New Jersey
Gurjun Light - Copaene
The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%). Uses: Fragrance Products. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-002. Olfactive Profile: Balsamic, woody, sweet, greasy, pepper. EC No: 232-444-8. Origin: Indonesia.
New Jersey
Gurjun Light - Gurjunene
The crude oil collected from gurjun tree (Popularly known as : Keruing Timber Tree or Kayu Lagan) is naturally dark in appearance, hence known as gurjun dark. The crude oil can also be re-distilled to obtain gurjun light Gurjun is primarily cultivated in the southeast asia region (Malay Peninsula, Sumatra, Borneo, The Philippines, Java, Bali, Lombok and Sumbawa). It is, however, important to note that the oils obtained from Gurjun trees in the above listed countries have different constituents The Indonesian variety of Gurjun oil has Alpha Copaene (Min 40%) as it's main component. The other quality from Malaysia/ Vietnam/ Cambodia is different as the main constituent is Gurjunene (Min 40%). Uses: Fragrance Products. Group: Plant Extracts. INCI Names: Dipterocarpus Oleoresin Balsam. Grades: INDUSTRIAL GRADE. CAS No. 8030-55-5. Pack Sizes: 25 kgs Jerrycan, 200 kg Drums. Product ID: GB-004. Olfactive Profile: Balsamic, woody, earthy and warm. EC No: 232-444-8. Origin: Malaysia.
New Jersey
Gusacitinib
Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASN-002. CAS No. 1425381-60-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103018.
Guselkumab
Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNTO 1959. CAS No. 1350289-85-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9931.
Gusperimus Trihydrochloride
Gusperimus Trihydrochloride is an immunosuppressive agent, which was effective both in preventing and treating graft-vs.-host disease in mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 85468-01-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C17H37N7O3; 3(HCl), Molecular Weight: 387.523364599999. US Biological Life Sciences.
Worldwide
Gut Microbial Metabolite Library
A unique collection of 352 gut microbial metabolites which can be used for HTS and HCS. Uses: Scientific use. Product Category: L2540. Categories: Gut Microbial Metabolite Libraries.
Gut restricted-7
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR-7. CAS No. 2553218-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135747.
Gut restricted-7
Gut restricted-7 is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice. Alternative Names: GR-7. Grades: 99%. CAS No. 2553218-46-3. Molecular formula: C25H40FNaO6S. Mole weight: 495.64.
Guvacine hydrochloride
Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Uses: Scientific research. Category: Signaling pathways. CAS No. 6027-91-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100809.
Guvacine Hydrochloride
Guvacine hydrochloride is a specific GABA uptake inhibitor (IC50 = 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1, respectively). Guvacine may be beneficial for the treatment of neuropsychiatric disorders. Alternative Names: 1,2,5,6-Tetrahydropyridine-3-carboxylic acid hydrochloride. Grades: ≥99% by HPLC. CAS No. 6027-91-4. Molecular formula: C6H9NO2.HCl. Mole weight: 163.6.
Guvacine Hydrochloride
A GABA uptake inhibitor. It is used for the treatment of neurodegenerative diseases. Group: Biochemicals. Alternative Names: 1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride; 1,2,5,6-Tetrahydro-. Grades: Highly Purified. CAS No. 6027-91-4. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Guvacoline hydrobromide
Guvacoline hydrobromide. Group: Biochemicals. Alternative Names: 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide. Grades: Highly Purified. CAS No. 17210-51-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C7H12BrNO2. US Biological Life Sciences.
Worldwide
Guvacoline hydrobromide
Guvacoline is a natural alkaloid that is found in areca nuts. Guvacoline acts as a full agonist of atrial and ileal muscarinic receptors. Alternative Names: 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, methyl ester, hydrobromide (1:1); 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, methyl ester, monohydrobromide; Nicotinic acid, 1,2,5,6-tetrahydro-, methyl ester, hydrobromide; Guvacoline monohydrobromide; Methyl 1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide; Methyl 1,2,5,6-tetrahydronicotinate hydrobromide. Grades: ≥98%. CAS No. 17210-51-4. Molecular formula: C7H11NO2.HBr. Mole weight: 222.08.
Guvacoline hydrobromide
Guvacoline hydrobromide, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal mAChR[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17210-51-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116490.
A useful tool in the identification of muscarinic receptors. Group: Biochemicals. Alternative Names: Norarecoline, Guvacine Methyl Ester, Hydrobromide. Grades: Highly Purified. CAS No. 17210-51-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Guvacoline hydrochloride
Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6197-39-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5016.
GW0742
GW0742. Group: Biochemicals. Alternative Names: 4-[[[2-[3-Fluoro-4- (trifluoromethyl) phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy] acetic acid. Grades: Highly Purified. CAS No. 317318-84-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C21H17F4NO3S2. US Biological Life Sciences.
Worldwide
GW0742
GW0742 is a potent and highly selective PPARβ/δ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Alternative Names: GW0742; GW-0742; GW 0742; GW0742X; GW-0742X; GW 0742X; GW610742; GW-610742; GW 610742. Grades: >98%. CAS No. 317318-84-6. Molecular formula: C21H17F4NO3S2. Mole weight: 471.49.
GW0742
GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW610742. CAS No. 317318-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13928.
GW 1100
GW 1100 is a selective G protein-coupled receptor GPR40 antagonist. GW 1100 has been shown to reverse the effects GPR40 agonists which induce glucose-stimulated insulin secretion. Group: Biochemicals. Alternative Names: 4-[5-[ (2-Ethoxy-5-pyrimidinyl) methyl]-2-[[ (4-fluorophenyl) methyl]thio]-4-oxo-1 (4H) -pyrimidinyl]benzoic Acid Ethyl Ester; 1-(4-Ethoxycarbonylphenyl)-2-(4-fluorobenzylthio)-5-(2-ethoxy-5-pyrimidinylmethyl)-4-pyrimidinone. Grades: Highly Purified. CAS No. 306974-70-9. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
GW-1100
GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9. Uses: Scientific research. Category: Signaling pathways. CAS No. 306974-70-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-50691.
GW1929
GW 1929 is an orally active peroxisome proliferator-activated receptor-γ (PPARγ) agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW 1929 (hydrochloride) has antidiabetic efficacy and neuroprotective potential[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 196808-24-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15655.
GW1929
A potent, tyrosine-based peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 13 nM for murine receptor and 6.2 nM for human receptor in cell-based transactivation assays). Alternative Names: GW 1929; GW-1929. Grades: >98%. CAS No. 196808-24-9. Molecular formula: C30H29N3O4. Mole weight: 495.57.
GW1929
Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis and apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. GW1929 is an antidiabetic; the glucose-lowering effect in rats is 100-fold more potent than that of troglitazone. Group: Biochemicals. Alternative Names: N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist; (2S) - ( (2-Benzoylphenyl) amino-3- [4- [2- (methylpyridin-2-ylamino) ethoxy] phenyl] propionic acid. Grades: Highly Purified. CAS No. 196808-24-9. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C30H29N3O4. US Biological Life Sciences.
Worldwide
GW2580
GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 870483-87-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10917.
GW274150
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 210354-22-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119.
GW274150 phosphate
GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 438542-15-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119A.
GW274150 phosphate
GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 μM). Grades: 98%. CAS No. 438542-15-5. Molecular formula: C8H20N3O6PS. Mole weight: 317.30.
GW280264X
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 866924-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115670.
GW2974
GW2974 is a potent dual inhibitor of EGFR and HER2 with IC50 value of 0.007 μM and 0.016 μM, respectively. GW2974 demonstrates in vitro inhibition of the EGFR and HER2 and inhibits the growth of tumor cell. GW2974 can be used for glioblastoma multiforme (GBM) disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 202272-68-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112293.
GW311616 hydrochloride
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW311616A. CAS No. 197890-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-15891A.
GW3965
GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 405911-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627.
GW3965 hydrochloride
GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 405911-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627A.
GW3965 Hydrochloride
GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM in cell-free assays, respectively. Group: Inhibitors. CAS No. 405911-17-3. Pack Sizes: 5mg. Product ID: S2630. Formula: C33H31ClF3NO3.HCl. Smiles: C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl. Storage Conditions: 2 years -80 in solvent.
United States; Europe
GW3965 Hydrochloride
GW3965 HCl is a potent, selective LXR agonist for hLXRα and hLXRβ with EC50 of 190 and 30 nM, respectively. Alternative Names: GW3965 Hydrochloride; GW 3965 Hydrochloride; GW-3965 Hydrochloride. Grades: >98%. CAS No. 405911-17-3. Molecular formula: C33H31ClF3NO3.HCl. Mole weight: 618.51.
GW 4064 is a potent FXR agonist with an EC50 of 65 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 278779-30-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50108.
GW 441756
GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 504433-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18314.
GW 441756
GW 441756 is a potent and selective Tropomyosin-related kinase A (TrkA) inhibitor (IC50 = 2 nM), reducing cell proliferation and potentiates the effects of chemotherapeutic agents. Uses: A specific tropomyosin-related kinase a (trka) inhibitor. Alternative Names: GW-441756; GW 441756; GW441756. 1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one;(3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one. Grades: ≥98%. CAS No. 504433-23-2. Molecular formula: C17H13N3O. Mole weight: 275.30.
GW4869 is a cell-permeable, specific and non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM). Alternative Names: (E)-3-[4-[(E)-3-[4-(4,5-dihydro-1H-imidazol-2-yl)anilino]-3-oxoprop-1-enyl]phenyl]-N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]prop-2-enamide;dihydrochloride; GW 4869; GW-4869. CAS No. 6823-69-4. Molecular formula: C30H30Cl2N6O2. Mole weight: 577.5.
GW4869
GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM, also is a commonly used exosome inhibitor. Group: Inhibitors. Alternative Names: GW69A, GW554869A. CAS No. 6823-69-4. Pack Sizes: 5mg. Product ID: S7609. Formula: C30H28N6O2.2HCl.XH2O. Smiles: C1CN=C(N1)C2=CC=C(C=C2)NC(=O)C=CC3=CC=C(C=C3)C=CC(=O)NC4=CC=C(C=C4)C5=NCCN5.Cl.Cl. Storage Conditions: 2 years -80 in solvent.
United States; Europe
GW4869
GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6823-69-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-19363.
GW 501516
An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα and PPAR&gamma. Does not exibit any activity against other nuclear or non-nuclear receptors. Reported to increase cholesterol efflux and ABAC1 expression in macrophages, fibroblasts, and intestinal cells. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; GW 1516; Endurobol. Grades: Highly Purified. CAS No. 317318-70-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C??H??F?NO?S?, Molecular Weight: 453.5. US Biological Life Sciences.
Worldwide
GW 501516
GW 501516 (GW 1516) is a PPARδ agonist with an EC50 of 1.1 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW 1516; GSK-516. CAS No. 317318-70-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-10838.
GW 501516 Methyl Ester
Precursor to GW 501516. Group: Biochemicals. Alternative Names: 2- [2-Methyl-4- [ [ [4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid. Grades: Highly Purified. CAS No. 317318-69-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
GW 5074
GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220904-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10542.
GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a Ki <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 853953-65-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138559.
GW627368
GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 439288-66-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16963.
GW 627368X
GW 627368X is a potent and selective competitive antagonist of the EP4 receptor with additional human TP receptor affinity (Ki values of 100 nM and 158 nM, respectively). Uses: A potent and selective competitive antagonist. Alternative Names: GW627368X; GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368. N-(benzenesulfonyl)-2-[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)phenyl]acetamide; 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)-benzeneacetamide. Grades: ≥96%. CAS No. 439288-66-1. Molecular formula: C30H28N2O6S. Mole weight: 544.62.
GW6340
GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 405910-78-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154928.
GW6471
GW6471 is a selective peroxisome proliferator-activated receptor α (PPARα) antagonist. GW6471 reduces cancer stem cell viability, proliferation, and spheroid formation. GW6471 induces apoptosis and causes metabolic impairment including energy imbalance. GW6471 can be used for the research of paragangliomas and triple-negative breast cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 880635-03-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15372.
GW6471
GW 6471 is a potent antagonist of PPARα with IC50 of 0.24 μM. Group: Inhibitors. CAS No. 880635-03-0. Pack Sizes: 10mg. Product ID: S2798. Formula: C35H36F3N3O4. Smiles: CCC(=O)NCC(CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)NC(=CC(=O)C4=CC=C(C=C4)C(F)(F)F)C. Storage Conditions: 2 years -80 in solvent.
United States; Europe
GW7647
GW7647 is a potent PPARα agonist, with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 265129-71-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13861.