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| Product | Description | |
|---|---|---|
| JHU-083 | JHU-083, a proagent of 6-diazo-5-oxo-L-norleucine (DON; HY-108357), is an orally active and selective glutaminase antagonist. JHU-083 blocks glutaminase activity in brain CD11b+ cells and experimental cerebral malaria (ECM) resulting in a net decrease of glutamate levels in the animals[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1998725-11-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122218. |  |
| JHU395 | JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) proagent. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2079938-92-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-128775. | |
| JHW 007 hydrochloride | JHW 007 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 202645-74-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| JH-X-119-01 | JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice[1]. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2227368-54-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103017A. | |
| JH-X-119-01 hydrochloride | JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2591344-30-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-103017. | |
| JH-XI-10-02 | JH-XI-10-02 is a PROTAC connected by ligands for Cereblon and CDK. JH-XI-10-02 is a highly potent and selective PROTAC CDK8 degrader, with an IC50 of 159 nM. JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2209085-22-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-111518. | |
| JH-XII-03-02 | JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2415900-86-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-155150. | |
| JH-XVI-178 | JH-XVI-178 is a highly efficient and selective CDK8/19 inhibitor, with IC50 values of 1 and 2 nM for CDK8 and CDK19, respectively. JH-XVI-178 has a low clearance rate and moderate oral pharmacokinetic properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2648453-53-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139875. | |
| JI051 | JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2234281-75-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117113. | |
| JI-101 | JI-101 is an orally available multi-kinase inhibitor of VEGFR2, PDGFRβ and EphB4 with potent anti-cancer activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 900573-88-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16265. | |
| JIB 04 | JIB 04. Group: Biochemicals. Grades: Purified. CAS No. 199596-05-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JIB-04 | JIB-04 Inhibitor. Uses: Scientific use. Product Category: T1868. CAS No. 199596-05-9. |  |
| JIB-04 | JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 199596-05-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13953. | |
| Jietacin A | Jietacin A is originally isolated from Str. sp. KP-197. It is found to be resistant to nematode, it can 100% kill Burs helenchus Lignicolus with the concentration of 0.25μg/mL, which is 10 times stronger than Avermectin B1a. Synonyms: Jietacine A; BRN 5538455; 1-(Ethenyl-ONN-azoxy)-14-methyl-8-pentadecanone. CAS No. 109766-61-2. Molecular formula: C18H34N2O2. Mole weight: 310.47. |  |
| Jietacin B | Jietacin B is originally isolated from Str. sp. KP-197. It is found to be resistant to nematode, it can 100% kill Burs helenchus Lignicolus with the concentration of 0.25μg/mL, which is 10 times stronger than Avermectin B1a. CAS No. 109766-62-3. Molecular formula: C19H36N2O2. Mole weight: 324.50. | |
| Jindongenin-1a | Jindongenin-1a is an antibacterial peptide isolated from Amolops jingdongensis (Chinese torrent frog). It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Jindongenin-1a can help to solve the serious problem of bacterial resistance to currently used antibiotics. Synonyms: Ser-Met-Gly-Ala-Val-Lys-Leu-Ala-Lys-Leu-Leu-Ile-Asp-Lys-Met-Lys-Cys-Glu-Val-Thr-Lys-Ala-Cys. Grade: 95.6%. | |
| Jinflexin A | Jinflexin A is a remarkable and potent pharmacological natural compound, finding extensive application for studying various ailments such as rheumatoid arthritis, osteoarthritis and diverse inflammatory joint disorders. This multifaceted natural compound exerts its mechanism of action via the proficient inhibition of pro-inflammatory cytokine production. Grade: 96.0%. CAS No. 2055155-75-2. Molecular formula: C19H22O3. Mole weight: 298.382. | |
| Jingdongin-1 | Jingdongin-1 is an antibacterial peptide isolated from Amolops jingdongensis (Chinese torrent frog). It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: Phe-Leu-Pro-Leu-Phe-Leu-Pro-Lys-Ile-Ile-Cys-Val-Ile-Thr-Lys-Lys-Cys. Grade: 96.4%. Mole weight: 1976.6. | |
| Jingzhaotoxin III | Jingzhaotoxin III is a selective blocker of NaV1.5 channels with IC50 value of 348 nM. It is selective for NaV1.5 channels and shows no effect on other isoforms. It inhibits the activation of cardiac sodium channels by binding to the NaV1.5 S3-S4 linker of domain II. It has no effect on sodium channels in dorsal root ganglion neurons. Synonyms: H-Asp-Gly-Glu-Cys(1)-Gly-Gly-Phe-Trp-Trp-Lys-Cys(2)-Gly-Arg-Gly-Lys-Pro-Pro-Cys(3)-Cys(1)-Lys-Gly-Tyr-Ala-Cys(2)-Ser-Lys-Thr-Trp-Gly-Trp-Cys(3)-Ala-Val-Glu-Ala-Pro-OH; L-alpha-aspartyl-glycyl-L-alpha-glutamyl-L-cysteinyl-glycyl-glycyl-L-phenylalanyl-L-tryptophyl-L-tryptophyl-L-lysyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-lysyl-L-prolyl-L-prolyl-L-cysteinyl-L-cysteinyl-L-lysyl-glycyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-seryl-L-lysyl-L-threonyl-L-tryptophyl-glycyl-L-tryptophyl-L-cysteinyl-L-alanyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-proline (4->19),(11->24),(18->31)-tris(disulfide). Grade: >98%. CAS No. 925463-91-8. Molecular formula: C174H241N47O46S6. Mole weight: 3918.44. | |
| Jingzhaotoxin III | Jingzhaotoxin III. Group: Biochemicals. Grades: Purified. CAS No. 925463-91-8. Pack Sizes: 100ug. US Biological Life Sciences. | Worldwide |
| Jionoside A1 | Jionoside A1. Group: Biochemicals. CAS No. 120444-60-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Jionoside B1 | Jionoside B1. Group: Biochemicals. Grades: Plant Grade. CAS No. 120406-37-3. Pack Sizes: 5mg. Molecular Formula: C37H50O20, Molecular Weight: 814.79. US Biological Life Sciences. | Worldwide |
| JIP-1 (153-163) | JIP-1 (153-163) has been found to be a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Synonyms: TI-JIP. Grade: >98%. CAS No. 438567-88-5. Molecular formula: C61H104N20O14. Mole weight: 1341.6. | |
| JIP-1 (153-163) acetate | JIP-1 (153-163) acetate is a c-Jun N-terminal kinase (JNK) peptide inhibitor based on JNK-interacting protein-1 (JIP-1) residues 153-163. It binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Synonyms: L-Phenylalaninamide, L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparaginyl-L-leucyl-, acetate (1:1); H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2.CH3CO2H; L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparagyl-L-leucyl-L-phenylalaninamide acetate salt. Grade: ≥95%. CAS No. 1417623-78-9. Molecular formula: C61H104N20O14.C2H4O2. Mole weight: 1401.66. | |
| JJH260 | JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1831135-30-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116895. | |
| JJKK 048 | JJKK 048. Group: Biochemicals. Grades: Purified. CAS No. 1515855-97-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JK 184 | JK 184. Group: Biochemicals. Grades: Purified. CAS No. 315703-52-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JK 184 (N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine) | An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC50 = 210 nM). Group: Biochemicals. Alternative Names: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine. Grades: Highly Purified. CAS No. 315703-52-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| JKC363 | JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 436083-30-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1213. | |
| JKC 363 | JKC 363. Group: Biochemicals. Grades: Purified. CAS No. 436083-30-6. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| JKC 363 | JKC 363 has been found to be a melanocortin MC4 receptor antagonist and could suppress the release of thyrotropin-releasing hormone (TRH). Synonyms: (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide; JKC363; JKC-363; 3-Mercaptopropionyl-Glu-His-D-2-Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bond); deamino-Cys-Glu-His-D-2Nal-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asn-OH (Disulfide bridge: Cys1-Cys8); deamino-cysteinyl-L-alpha-glutamyl-L-histidyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-tryptophyl-glycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-L-asparagine (1->8)-disulfide; beta-MSH (11-12)-amide, mercaptopropionic acid(11)-naphthylalanyl(14)-cysteinyl(18)-aspartyl(22)-; beta-MSH (11-22)-amide, Mrp(11)-Nal(14)-Cys(18)-Asp(22)-; [Deamino-Cys11,β-(2-Naphthyl)-D-Ala14,Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22. Grade: ≥95% by HPLC. CAS No. 436083-30-6. Molecular formula: C69H91N19O16S2. Mole weight: 1506.72. | |
| JKE-1674 | JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2421119-60-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138153. | |
| JLK 6 | JLK 6. Group: Biochemicals. Grades: Purified. CAS No. 62252-26-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JMJD1C-IN-1 | JMJD1C-IN-1 is an orally active and selective inhibitor of JMJD1C (IC50 = 0.59 μM, Kd = 1.96 μM). JMJD1C-IN-1 inhibits the binding of JMJD1C to H3K9me2 peptide substrate in the HTRF assay (IC50 = 1.47 μM). JMJD1C-IN-1 disrupts intratumoral regulatory T (Treg) cell fitness by dual mechanisms: promoting H3K9me2 accumulation to downregulate PD1 expression and reducing STAT3 demethylation to enhance STAT3 activation. JMJD1C-IN-1 demonstrates dose-dependent antitumor efficacy in multiple mouse tumor models (MCA205 fibrosarcoma, B16-F10 melanoma, LLC lung cancer, Hepa1-6 hepatocellular carcinoma, CT26 colorectal cancer). JMJD1C-IN-1 can be used for the study of tumor immunotherapy by selectively targeting intratumoral Treg cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 861224-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162275. | |
| JMJD6-IN-1 | JMJD6-IN-1 is a JMJD6 inhibitor, with an inhibition rate of 82% at 10 μM. JMJD6-IN-1 inhibits MCF-7 and HCC4006 cell proliferation with IC50 values of 19.2 μM and 25.2 μM. JMJD6-IN-1 inhibits JMJD6 demethylase activity. JMJD6-IN-1 can be used for the research of lung adenocarcinoma, prostate cancer, breast cancer, pancreatic cancer, colon cancer, oral squamous cell carcinoma, and glioblastoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 899548-78-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-139434. | |
| JMJD Histone Demethylase Inhibitor III ( (E) -4- (Hydroxy (4- (4- ( (naphthalen-1-ylcarbamoyloxy) methyl) benzylamino) butyl) amino) -4-oxobut-2-enoic Acid) | A substrate (methyl lysine) and cofactor (a-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50=4.3, 3.4, 5.9, 10 and 43uM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50=54, 83, 31, 22, 620, 680 and >800uM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| JMJD Histone Demethylase Inhibitor IV, Methylstat ( (E) -Methyl-4- (hydroxy (4- ( (4- ( ( (naphthalen-1-ylcarbamoyl) oxy) methyl) benzyl) amino) butyl) amino) -4-oxobut-2-enoate, Histone Lysine Demethylase Inhibitor VII, Methylstat) | A methyl ester prodrug of in vitro active N-hydroxybutenoic acid compound that is shown to preferentially induce hypermethylation of histone proteins (EC50 for H3K4me3 and H3K9me3=10.3 and 8.6uM in KYSE150 cells, and 6.7 and 6.3uM in MCF7 cells, respectively), and arrests cell growth. Acts as a selective inhibitor of Jumonji domain-containing histone demethylases (JHDMs) over prolyl hydroxylases (PHDs), and prevents myogenesis through inhibition of H3K27 demethylase UTX in C2C12 cells at 2uM. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JMS-053 | JMS-053 is an efficient and reversible PTP4A3 inhibitor, with an IC50 value of 18 nM.JMS-053 demonstrates broad PTP4A inhibitory activity with IC50s of 50 nM and 53 nM for PTP4A1 and PTP4A2, respectively. JMS-053 exhibits IC50 values of 92.6 nM and 207.6 nM for CDC25B and DUSP3, respectively. JMS-053 can effectively inhibit the activity of PTP4A3, inhibit tumor cell proliferation and migration through multiple mechanisms such as interfering with RhoA and STAT3/p38 signaling pathway. JMS-053 can be used for the study of cancers such as ovarian cancer, breast cancer and colon cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1954650-11-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-135457. | |
| JMS-17-2 | JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1380392-05-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123918. | |
| JMV 2959 | JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 925238-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00433. | |
| JMV 2959 hydrochloride | JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 2448414-54-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-U00433A. | |
| JMV 390-1 | JMV 390-1 has been found to be an inhibitor of the major neurotensin and neuromedin N degrading enzymes and could probably show analgesic activities. Synonyms: Jmv-390-1; Jmv390-1; N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine. Grade: ≥95% by HPLC. CAS No. 148473-36-3. Molecular formula: C23H35N3O6. Mole weight: 449.54. | |
| JMV 390-1 | JMV 390-1. Group: Biochemicals. Grades: Purified. CAS No. 148473-36-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| JMV 449 | JMV 449. Group: Biochemicals. Grades: Purified. CAS No. 139026-66-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| JMV 449 | JMV 449 could be a neurotensin receptor agonist peptide and has been found to show hypothermic and analgesic activities in the mouse. Synonyms: JMV-449; JMV449; (S)-1-de-L-lysine-2-[N2-(2,6-diaminohexyl)-L-lysine]-neuromedin N (pig spinal cord); H-Lysy(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH. Grade: ≥95% by HPLC. CAS No. 139026-66-7. Molecular formula: C38H66N8O7. Mole weight: 746.96. | |
| JND3229 | JND3229 is a reversible EGFRC797S inhibitor with IC50 values of 5.8, 6.8 and 30.5 nM for EGFRL858R/T790M/C797S, EGFRWT and EGFRL858R/T790M, respectively. JND3229 has good anti-proliferative activity and can effectively inhibit tumour growth in vivo. JND3229 can be used in cancer research, especially in non-small cell carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2260886-64-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119944. | |
| JNJ0966 | JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 315705-75-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103482. | |
| JNJ-1013 | JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2597343-08-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153188. | |
| JNJ 10181457 | JNJ 10181457. Group: Biochemicals. Alternative Names: 4- [3- [4- [Piperidinyl] but-1-ynyl] benzyl] morpholine. Grades: Highly Purified. CAS No. 544707-19-9. Pack Sizes: 10mg. Molecular Formula: C20H28N2O, Molecular Weight: 312.45. US Biological Life Sciences. | Worldwide |
| JNJ 10191584 maleate | JNJ 10191584 maleate. Group: Biochemicals. Grades: Purified. CAS No. 869497-75-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-10229570 | JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 524923-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107139. | |
| JNJ 10397049 | JNJ 10397049. Group: Biochemicals. Alternative Names: N-(2,4-Dibromophenyl)-N'-[(4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl]-urea; 1-(2,4-Dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)urea. Grades: Highly Purified. CAS No. 708275-58-5. Pack Sizes: 1mg. Molecular Formula: C19H20Br2N2O3, Molecular Weight: 484.18. US Biological Life Sciences. | Worldwide |
| JNJ-1289 | JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 792898-18-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151115. | |
| JNJ-16241199 | JNJ-16241199 (R306465) is an orally active, selectivehydroxamate-based histone deacetylase (HDAC) inhibitor, with theIC50of 3.3 nM and 23 nM for HDAC1and HDAC8, respectively.JNJ-16241199induces histone 3 acetylation and strongly increasesthe expression of p21waf1, cip1 in A2780 ovarian carcinoma cells.JNJ-16241199 inducescell apoptosisand shows anticancer activityin a broad spectrum of human malignancies. JNJ-16241199 can be used for cancer study[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R306465. CAS No. 604769-01-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-10226. | |
| JNJ16259685 | JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 409345-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100407. | |
| JNJ 16259685 | JNJ 16259685. Group: Biochemicals. Alternative Names: (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone. Grades: Highly Purified. CAS No. 409345-29-5. Pack Sizes: 10mg. Molecular Formula: C20H23NO3, Molecular Weight: 325.399999999999. US Biological Life Sciences. | Worldwide |
| JNJ 1661010 | JNJ 1661010. Group: Biochemicals. Grades: Purified. CAS No. 681136-29-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ 17203212 | JNJ 17203212. Group: Biochemicals. Grades: Purified. CAS No. 821768-06-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-17203212 | JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 821768-06-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100129. | |
| JNJ-18038683 | JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 851376-05-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19889. | |
| JNJ 27141491 | JNJ 27141491. Group: Biochemicals. Grades: Purified. CAS No. 871313-59-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ-27141491 | JNJ-27141491 is a selective, noncompetitive and orally active functional antagonist of human CCR2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 871313-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110132. | |
| JNJ-28583113 | JNJ-28583113 is an TRPM2 antagonist with brain permeability. JNJ-28583113 inhibits TRPM2 blocked phosphorylation of GSK3α and β subunits. JNJ-28583113 protects cells from oxidative stress induced cell death. JNJ-28583113 also suppresses cytokine release in response to pro-inflammatory stimuli in microglia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765255-93-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-149143. | |
| JNJ 28871063 hydrochloride | JNJ 28871063 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 944342-90-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JNJ 303 | JNJ-303 is a specific delayed rectifier Kv blocker. JNJ 303 can potent block IKs with an IC50 value of 64 nM. JNJ-303 can be used for the research of diabetes, obesity and central nervous system[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 878489-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16953. | |
| JNJ-31020028 | JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1094873-14-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14450. | |
| JNJ-3738 | JNJ-3738 (Compound 148) is the inhibitor for CDK7 with a Ki of 21.75 nM. JNJ-3738 inhibits the proliferation of CDK7 WT expressing A549 with pIC50 of 7.37[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2796279-20-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-172194. | |
| JNJ-37822681 dihydrochloride (Standard) | JNJ-37822681 (dihydrochloride) (Standard) is the analytical standard of JNJ-37822681 (dihydrochloride). This product is intended for research and analytical applications. JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2108806-02-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111066AR. | |
| JNJ-39758979 | JNJ-39758979, a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1046447-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101189. | |
| JNJ-40411813 | JNJ-40411813 (ADX-71149) is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ADX-71149. CAS No. 1127498-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15748. | |
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