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| Product | Description | |
|---|---|---|
| JNJ-54717793 | JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC50=85 ng/mL). The Ki values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628843-99-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134188. |  |
| JNJ-55308942 | JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2166558-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123857. | |
| JNJ-6204 | JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765264-50-2. Pack Sizes: 1 mg. Product ID: HY-148233S. | |
| JNJ-63533054 | JNJ-63533054 is a potent, selective and orally active GPR139 agonist with an EC50 of 16 nM for human GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ-63533054 can cross the blood-brain barrier (BBB)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802326-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19838. | |
| JNJ-63576253 | JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TRC-253. CAS No. 2110428-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115282A. | |
| JNJ-74856665 | JNJ-74856665 (DHODH-IN-16) is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHODH-IN-16. CAS No. 2511248-11-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139189. | |
| JNJ-7706621 | JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC50s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 443797-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10329. | |
| JNJ-7706621 | JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma. Group: Biochemicals. Alternative Names: N3-[4-(Aminosulfonyl)phenyl]-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazole-3,5-diamine; 4- [ [5-Amino-1- (2, 6-difluorobenzoyl) -1H- [1, 2, 4] triazol-3-yl] amino] benzenesulfonamide; JNJ 770662. Grades: Highly Purified. CAS No. 443797-96-4. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| JNJ-7777120 | JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 459168-41-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13508. | |
| JNJ-9350 | JNJ-9350, a chemical probe, is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 326923-09-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Q36392. | |
| JNJ-9676 | JNJ-9676 is an orally active Coronavirus M protein inhibitor and selective Sarbecovirus inhibitor. JNJ-9676 binds to the M protein dimer and forces the protein into an alternative conformational state with a compound-induced binding pocket. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and Sarbecovirus strains from bat and pangolin zoonotic origin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3026520-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173521. | |
| JNJ-DGAT2-A | JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1962931-71-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110381. | |
| JNK-1-IN-5 | JNK-1-IN-5 (Compound 14) is a potent JNK1 inhibitor with sub-nanomolar efficacy. JNK-1-IN-5 suppresses TGF-β-induced epithelial-mesenchymal transition. JNK-1-IN-5 is promising for research of anti-pulmonary fibrosis agent targeting JNK1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3047794-08-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170420. | |
| JNK1 + JNK2 + JNK3 Antibody [M18P18] | Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, PRKM8, SAPK1, SAPK1C, Mitogen-activated protein kinase 9, MAP kinase 9; MAPK 9, JNK-55, Stress-activated protein kinase 1a, SAPK1a, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, MAPK9, JNK2, PRKM9, SAPK1A, Mitogen-activated protein kinase 10, MAP kinase 10; MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3. Group: Antibodies. Alternative Names: MAPK 8, MAPK 9, MAPK 10. CAS No. Pack Sizes: 20uL. Product ID: F1574. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| JNK3 inhibitor-4 | JNK3 inhibitor-4 is a potent and BBB-permeable inhibitor of JNK3 (IC50=1.0 nM) based on 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile. JNK3 inhibitor-4 shows excellent selectivity over other protein kinases including isoforms JNK1 (IC50=143.9 nM) and JNK2 (IC50=298.2 nM)[1]. JNK3 inhibitor-4 has neuroprotective effect and predicated blood-brain barrier permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2409109-65-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-151929. | |
| JNK-IN-7 | JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNK inhibitor. CAS No. 1408064-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15617. | |
| JNK-IN-8 | JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNK Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13319. | |
| JNK-IN-8 | JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line. Group: Inhibitors. Alternative Names: JNK Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 5mg. Product ID: S4901. Formula: C29H29N7O2. Smiles: CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)C=CCN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JNK Inhibitor VIII | JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TCS JNK 6o. CAS No. 894804-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-107598. | |
| JNT-517 | JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2837993-05-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156682. | |
| Jojoba oil | Jojoba oil. CAS No. 61789-91-1. Purity: 0.98. Product ID: CI-EO-0041. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Jojoba Oil Golden | Jojoba Oil Golden. |  CA, FL & NJ |
| Jolkinolide B | Jolkinolide B. Group: Biochemicals. Grades: Plant Grade. CAS No. 37905-08-1. Pack Sizes: 10mg. Molecular Formula: C20H26O4, Molecular Weight: 330.42. US Biological Life Sciences. | Worldwide |
| Josamycin | Josamycin is a main component of YL-704, a macrolide antibiotic complex isolated from Streptomyces platensis subsp. malvinus. It is active against gram-positive bacteria. Synonyms: YL-704A3; YL 704A3; YL 704 A3; Leucomycin A3; Turimycin A5; Kitasamycin A3; Josamycine. Grade: 95%. CAS No. 16846-24-5. Molecular formula: C42H69NO15. Mole weight: 828. |  |
| Josamycin | A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. Alternative Names: Iosalide;Vilprafen;Leucomycin A3;EN 141. CAS No. 16846-24-5. Purity: 98%. Product ID: ACM16846245. Molecular formula: C42H69NO15. Mole weight: 827.99. IUPAC Name: josamycin. ECNumber: 240-871-6. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Josamycin | Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EN-141. CAS No. 16846-24-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B1920. | |
| Josamycin Deisovaleryl Impurity | Josamycin Deisovaleryl Impurity. Uses: For analytical and research use. CAS No. 31642-61-2. Molecular formula: C37H61NO14. Mole weight: 743.89. Catalog: APB31642612. |  |
| Josamycin EP Impurity A | Josamycin EP Impurity A. Uses: For analytical and research use. CAS No. 18361-46-1. Molecular formula: C41H67NO15. Mole weight: 813.98. Catalog: APB18361461. | |
| Josamycin EP Impurity B | Josamycin EP Impurity B. Uses: For analytical and research use. CAS No. 40361-41-9. Molecular formula: C42H71NO15. Mole weight: 830.02. Catalog: APB40361419. | |
| Josamycin EP Impurity D | Josamycin EP Impurity D. Uses: For analytical and research use. CAS No. 22340-94-9. Molecular formula: C42H69NO15. Mole weight: 828.01. Catalog: APB22340949. | |
| Josamycin EP Impurity E | Josamycin EP Impurity E. Uses: For analytical and research use. CAS No. 40615-47-2. Molecular formula: C43H71NO15. Mole weight: 842.03. Catalog: APB40615472. | |
| Josamycin EP Impurity F | Josamycin EP Impurity F. Uses: For analytical and research use. Molecular formula: C35H59NO13. Mole weight: 701.85. Catalog: APB10552. | |
| Josamycin EP Impurity G | Josamycin EP Impurity G. Uses: For analytical and research use. Molecular formula: C37H61NO14. Mole weight: 743.89. Catalog: APB10553. | |
| Josamycin EP Impurity H | Josamycin EP Impurity H. Uses: For analytical and research use. Molecular formula: C40H67NO14. Mole weight: 785.97. Catalog: APB10555. | |
| Josamycin EP Impurity I | Josamycin EP Impurity I. Uses: For analytical and research use. Molecular formula: C38H63NO14. Mole weight: 757.92. Catalog: APB10554. | |
| Josamycin EP Impurity J | Josamycin EP Impurity J. Uses: For analytical and research use. Molecular formula: C43H71NO15. Mole weight: 842.03. Catalog: APB10556. | |
| Josamycin EP Impurity K | Josamycin EP Impurity K. Uses: For analytical and research use. Molecular formula: C40H65NO15. Mole weight: 799.95. Catalog: APB10557. | |
| Josamycin hydrochloride | Josamycin hydrochloride. Alternative Names: Josamycin HCl. CAS No. 11033-19-5. Purity: 98%. Product ID: ACM11033195. Molecular formula: C42H70ClNO15. Mole weight: 864.46. Alfa Chemistry - ISO 9001:32057 Certified. | |
| JP104 | JP104, a aryl carbamate, is an irreversible FAAH inhibitor with a pIC50 of ~8[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 887264-45-1. Pack Sizes: 5 mg. Product ID: HY-121558. | |
| JP-11646 | JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 (IC50 = 0.5 nM). JP11646 is freely reversible and ATP non-competitive. JP-11646 results in a decrease of PIM1, 2, and 3 mRNA. JP-11646 can effectively inhibit cell viability in small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas of the lung (LCNEC). JP-11646 can cause a decrease in p-4EBP-1 protein, increasing the cleavage of caspases while decreasing caspase-3. JP-11646 induces apoptosis or necroptosis in cells. JP-11646 leads to reductions in MYC paralogs. JP-11646 can be used for the study of SCLC, LCNEC, human acute leukemia (AML), multiple myeloma (MM), and triple-negative breast cancer (TNBC)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1902983-63-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115590. | |
| JP 1302 dihydrochloride | JP 1302 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1259314-65-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JP1302 dihydrochloride | JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259314-65-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103213. | |
| JP-153 | JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802937-26-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120417. | |
| JP-163-16 | JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-κB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL). (Pink: RelA/p65 Ligand (HY-174865); Blue: CRBN Ligand (HY-A0003); Black: Linker; CRBN Ligand+Linker (HY-160241))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3100147-70-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-174864. | |
| JPC0323 | JPC0323 is a dual 5-HT2C/5-HT2A receptor positive allosteric modulator. JPC0323 has on-target properties, acceptable plasma exposure and brain penetration. JPC0323 can be used for the research of neurological disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5972-45-2. Pack Sizes: 1 mg. Product ID: HY-155672. | |
| JPE-1375 | JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 μM) and reduces TNF levels (EC50=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254036-23-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148141. | |
| JPH203 | JPH203 Inhibitor. Uses: Scientific use. Product Category: TQ0081. CAS No. 1037592-40-7. |  |
| JPH203 (Nanvuranlat) | Nanvuranlat (JPH203, KYT-0353), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 μM) and cell growth (IC50=4.1 μM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. Group: Inhibitors. Alternative Names: KYT-0353. CAS No. 1037592-40-7. Pack Sizes: 5mg. Product ID: S8667. Formula: C23H19Cl2N3O4. Smiles: C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JPM-OEt | JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 262381-84-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102087. | |
| JPS036 | JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2669785-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-145819. | |
| JQ1 | JQ1 Inhibitor. Uses: Scientific use. Product Category: T2110. CAS No. 1268524-70-4. | |
| JQ-1-Azidopropylamine | JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2915642-70-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174995. | |
| JQ-1 carboxylic acid | JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4. Uses: Scientific research. Category: Signaling pathways. CAS No. 202592-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-78695. | |
| JQ-1 carboxylic acid-PEG3-C2-NH2 | JQ-1 carboxylic acid-PEG3-C2-NH2 is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2098790-24-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169150. | |
| JQAD1 | JQAD1 is a CRBN-dependent PROTAC that selectively targets EP300 for degradation. JQAD1 suppresses EP300 expression and the H3K27ac modification. JQAD1 induces apoptosis. JQAD1 can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2417097-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145765. | |
| JQKD82 trihydrochloride | JQKD82 (JADA82) trihydrochloride is a cell-permeable and selective KDM5 inhibitor. JQKD82 trihydrochloride increases H3K4me3 and can be used for the research of multiple myeloma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JADA82 trihydrochloride; PCK82 trihydrochloride. CAS No. 2863676-87-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138691A. | |
| JR14a | JR14a is a potent thiophene antagonist of human complement C3a receptor. JR14a shows selectivity for the human C3a receptor over C5a receptor. JR14a can suppress C3aR-mediated inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411440-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-138161. | |
| JR-AB2-011 | JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM)[1].JR-AB2-011 decreases the phosphorylation level of Akt, decreases MMP2 activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2411853-34-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122022. | |
| JS6 | JS6 is a Bcl3 inhibitor, and inhibits Bcl3-NF-kB1 binding. JS6 inhibits tumor cell growth in vitro and in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 950244-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152177. | |
| JSH-150 | JSH-150 Inhibitor. Uses: Scientific use. Product Category: T8484. CAS No. 2247481-21-4. | |
| JSH-150 | JSH-150 is a highly selective and potent CDK9 inhibitor with an IC50 of 1 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2247481-21-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-X0150. | |
| JSH-23 | JSH-23 is an inhibitor of NF-κB transcriptional activity, which inhibits LPS-stimulated nuclear factor (NF)-κB transcriptional activity in RAW 264.7 cells with an IC50 value of 7.1 μM, and interferes with LPS-induced NF-κB nuclear translocation without affecting IκB degradation. Group: Inhibitors. CAS No. 749886-87-1. Pack Sizes: 5mg. Product ID: S7351. Formula: C16H20N2. Smiles: CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JSH-23 | JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 749886-87-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13982. | |
| JS-K | JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH. JS-K induces reactive oxygen species (ROS) to mediate apoptosis. JS-K induces autophagy. JS-K inhibits invasion. JS-K has a broad spectrum anti-proliferative activity in cancer cells. JS-K reduces tumor volume and causes necrosis of implanted tumors in mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 205432-12-8. Pack Sizes: 1 mg. Product ID: HY-126193. | |
| JT010 | JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 917562-33-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111132. | |
| JTC 801 | JTC 801. Group: Biochemicals. Grades: Purified. CAS No. 244218-51-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2?nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 244218-51-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13274. | |
| JTE 013 | JTE 013. Group: Biochemicals. Grades: Purified. CAS No. 547756-93-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JTE-013 | JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 383150-41-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100675. | |
| JTE-607 | JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 188791-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110133. | |
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