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| Product | Description | |
|---|---|---|
| JNJ-40418677 | JNJ-40418677 is an orally active modulator of γ-secretase, can cross the blood-brain barrier. JNJ-40418677 inhibits Aβ42 and NS2B-NS3 protease, with IC50s of 200 nM and 3.9 μM, respectively. JNJ-40418677 displays good biological tolerance, can be use for Alzheimers disease research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1146594-87-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100604. |  |
| JNJ-42153605 | JNJ-42153605 is a positive allosteric modulator of the metabotropic glutamate 2 (mGlu2) receptor with an EC50 of 17 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254977-87-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18162. | |
| JNJ-42226314 | JNJ-42226314, a chemical probe, is a competitive, highly selective and reversible non-covalent monoacylglycerol lipase (MAGL) inhibitor. JNJ-42226314 demonstrates dose-dependent enhancement of the major endocannabinoid 2-arachidonoylglycerol (2-AG) as well as efficacy in models of neuropathic and inflammatory pain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1252765-13-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133130. | |
| JNJ-46281222 | JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254980-38-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120530. | |
| JNJ-46778212 | JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VU 0409551. CAS No. 1363281-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19559. | |
| JNJ4796 | JNJ4796 is an oral active fusion inhibitor of influenza virus, neutralizing influenza A group 1 viruses by inhibiting hemagglutinin (HA)-mediated fusion. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2241664-16-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122907. | |
| JNJ 47965567 | JNJ 47965567. Group: Biochemicals. Grades: Highly Purified. CAS No. 1428327-31-4. Pack Sizes: 10mg. Molecular Formula: C28H32N4O2S, Molecular Weight: 488.64. US Biological Life Sciences. |  Worldwide |
| JNJ-47965567 | JNJ-47965567 is a centrally permeable, high-affinity, selective P2X7 antagonist, with pKis of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1428327-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101418. | |
| JNJ-49095397 | JNJ-49095397 (RV568) is an inhaled narrow-spectrum kinase inhibitor (NSKI) against both the α and γ isoforms of p38 MAPK. JNJ-49095397 also inhibits SRC kinase family, specifically haematopoietic kinase (HCK) JNJ-49095397 shows potent anti-inflammatory effects and can be used for the research of chronic obstructive pulmonary disease (COPD) and asthma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RV568. CAS No. 1220626-82-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120595. | |
| JNJ 5207852 | JNJ 5207852. Group: Biochemicals. Alternative Names: 1-[3- (4- ( (Piperidin-1-yl) methyl) phenoxy) propyl]piperidine. Grades: Highly Purified. CAS No. 398473-34-2. Pack Sizes: 10mg. Molecular Formula: C20H32N2O, Molecular Weight: 316.48. US Biological Life Sciences. | Worldwide |
| JNJ525 | JNJ525 is a TNFα inhibitor with IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNFα and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2092913-64-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124339. | |
| JNJ-54175446 | JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1627902-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117508. | |
| JNJ-54717793 | JNJ-54717793, as a brain penetrant, is an orally active, selective and high affinity orexin-1 receptor (OX1R) antagonist (plasma EC50=85 ng/mL). The Ki values of JNJ-54717793 for hOX1R (human OX1R) and hOX2R are 16 nM and 700 nM, respectively. JNJ-54717793 is a potent compound of anxiety disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628843-99-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134188. | |
| JNJ-55308942 | JNJ-55308942 is a high-affinity, selective, brain-penetrant P2X7 functional antagonist (hP2X7: IC50=10 nM, Ki=7.1 nM; rP2X7: IC50=15 nM, Ki=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2166558-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123857. | |
| JNJ-6204 | JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765264-50-2. Pack Sizes: 1 mg. Product ID: HY-148233S. | |
| JNJ-63533054 | JNJ-63533054 is a potent, selective and orally active GPR139 agonist with an EC50 of 16 nM for human GPR139 (hGPR139). JNJ-63533054 shows selective for GPR139 over other GPCRs, ion channels, and transporters. JNJ-63533054 can cross the blood-brain barrier (BBB)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802326-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19838. | |
| JNJ-63576253 | JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TRC-253. CAS No. 2110428-64-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115282A. | |
| JNJ-74856665 | JNJ-74856665 (DHODH-IN-16) is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 0.396 nM for human DHODH[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DHODH-IN-16. CAS No. 2511248-11-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139189. | |
| JNJ-7706621 | JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma. Group: Biochemicals. Alternative Names: N3-[4-(Aminosulfonyl)phenyl]-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazole-3,5-diamine; 4- [ [5-Amino-1- (2, 6-difluorobenzoyl) -1H- [1, 2, 4] triazol-3-yl] amino] benzenesulfonamide; JNJ 770662. Grades: Highly Purified. CAS No. 443797-96-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| JNJ-7706621 | JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2, with IC50s of 9 nM, 3 nM, 11 nM, and 15 nM for CDK1, CDK2, aurora-A and aurora-B, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 443797-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10329. | |
| JNJ-7777120 | JNJ-7777120 is a potent and selective histamine H4 receptor antagonist (Ki=4.5 nM). JNJ-7777120 effectively blocks histamine-induced migration of mouse tracheal mast cells from connective tissue to epithelial cells. JNJ-7777120 also significantly blocks neutrophil infiltration in a mouse Zymosan-induced peritonitis model. JNJ-7777120 has a good potential to study antipruritic and anti-inflammatory[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 459168-41-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13508. | |
| JNJ-9350 | JNJ-9350, a chemical probe, is an inhibitor of spermine oxidase (SMOX) with an IC50 value of 0.01 μM. JNJ-9350 also inhibits polyamine oxidase (PAO) with an IC50 value of 0.79 μM. JNJ-9350 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 326923-09-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Q36392. | |
| JNJ-9676 | JNJ-9676 is an orally active Coronavirus M protein inhibitor and selective Sarbecovirus inhibitor. JNJ-9676 binds to the M protein dimer and forces the protein into an alternative conformational state with a compound-induced binding pocket. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and Sarbecovirus strains from bat and pangolin zoonotic origin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3026520-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173521. | |
| JNJ-DGAT2-A | JNJ-DGAT2-A is a selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 value of 0.14 μM in human DGAT2-expressing Sf9 insect cell membranes. JNJ-DGAT2-A can be used for the research of triglyceride (TG) synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1962931-71-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110381. | |
| JNK-1-IN-5 | JNK-1-IN-5 (Compound 14) is a potent JNK1 inhibitor with sub-nanomolar efficacy. JNK-1-IN-5 suppresses TGF-β-induced epithelial-mesenchymal transition. JNK-1-IN-5 is promising for research of anti-pulmonary fibrosis agent targeting JNK1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3047794-08-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170420. | |
| JNK1 + JNK2 + JNK3 Antibody [M18P18] | Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, PRKM8, SAPK1, SAPK1C, Mitogen-activated protein kinase 9, MAP kinase 9; MAPK 9, JNK-55, Stress-activated protein kinase 1a, SAPK1a, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, MAPK9, JNK2, PRKM9, SAPK1A, Mitogen-activated protein kinase 10, MAP kinase 10; MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3. Group: Antibodies. Alternative Names: MAPK 8, MAPK 9, MAPK 10. CAS No. Pack Sizes: 20uL. Product ID: F1574. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| JNK3 inhibitor-4 | JNK3 inhibitor-4 is a potent and BBB-permeable inhibitor of JNK3 (IC50=1.0 nM) based on 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile. JNK3 inhibitor-4 shows excellent selectivity over other protein kinases including isoforms JNK1 (IC50=143.9 nM) and JNK2 (IC50=298.2 nM)[1]. JNK3 inhibitor-4 has neuroprotective effect and predicated blood-brain barrier permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2409109-65-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-151929. | |
| JNK-IN-7 | JNK-IN-7 is a potent JNK inhibitor with IC50 of 1.5, 2 and 0.7 nM for JNK1, JNK2 and JNK3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNK inhibitor. CAS No. 1408064-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15617. | |
| JNK-IN-8 | JNK-IN-8 (JNK Inhibitor XVI) is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 4.7 nM, 18.7 nM and 1 nM, >10-fold selectivity against MNK2, Fms and no inhibition to c-Kit, Met, PDGFRβin A375 cell line. Group: Inhibitors. Alternative Names: JNK Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 5mg. Product ID: S4901. Formula: C29H29N7O2. Smiles: CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)NC(=O)C=CCN(C)C)NC3=NC=CC(=N3)C4=CN=CC=C4. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JNK-IN-8 | JNK-IN-8 (JNK Inhibitor XVI) is a potent JNK inhibitor with IC50s of 4.7 nM, 18.7 nM, and 1 nM for JNK1, JNK2, and JNK3, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNK Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13319. | |
| JNK Inhibitor II (Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125, SAPK Inhibitor II) | A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50=40nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-y, TNF-a, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 129-56-6. Pack Sizes: 5mg, 25mg, 50mg. Molecular Formula: C14H8N2O, Molecular Weight: 220.2. US Biological Life Sciences. | Worldwide |
| JNK Inhibitor VIII | JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TCS JNK 6o. CAS No. 894804-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-107598. | |
| JNK Inhibitor XVI, JNK-IN-8 ( (E) -3- (4- (dimethylamino) but-2-enamido) -N- (3-methyl-4- ( (4- (pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide) | A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50=4.67nM, 18.7nM, 980pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50=486nM in HeLa cells; 338nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50=92nM for V559D and 56nM for T670I) and RIOK2 (120nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JNK Inhibitor XV, IQ-1S (11H-Indeno[1,2-b]quinoxalin-11-one oxime, sodium salt) | A cell-permeable indenoquinoxalinone-oxime (IQ) compound that acts as a potent, non-toxic, reversible, ATP-competitive, high-affinity inhibitor of JNK (=390, 360 and 87nM for JNK1, JNK2 and JNK3, respectively) with moderate selectivity over CK1d, PI 3-Ky, and MKNK2 (IC50=1.4, 1.2, and 1.8uM, respectively). Shown to reduce c-Jun-Ser63 phosphorylation, and block the production of LPS-induced TNF-a (IC50 = 250nM) and IL-6 (IC50=610nM) in MonoMac-6 monocytic cells and in human hPBMCs, respectively. Also shown to inhibit NF-kB/AP-1 reporter activity (IC50=1.8uM) in human THP1-Blue monocytic cells and diminish nitric oxide production in murine J774-A.1 macrophages (IC50=12.5uM). Exhibits favorable pharmacokinetics properties and efficiently reduces ovalbumin-induced CD+ T-cell immune inflammation in a murine delayed-type hypersensitivity model (12.5mg/kg, two per day dosage, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H?N?Ona, Primary Target: JNK1,2,3. US Biological Life Sciences. | Worldwide |
| JNT-517 | JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC50 of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2837993-05-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156682. | |
| Jojoba oil | Jojoba oil. CAS No. 61789-91-1. Purity: 0.98. Product ID: CI-EO-0041. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Jojoba Oil Golden | Jojoba Oil Golden. |  CA, FL & NJ |
| Jolkinolide B | Jolkinolide B. Group: Biochemicals. Grades: Plant Grade. CAS No. 37905-08-1. Pack Sizes: 10mg. Molecular Formula: C20H26O4, Molecular Weight: 330.42. US Biological Life Sciences. | Worldwide |
| Josamycin | Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant Kd from ribosome for Josamycin is 5.5 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EN-141. CAS No. 16846-24-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B1920. | |
| Josamycin | Josamycin is a main component of YL-704, a macrolide antibiotic complex isolated from Streptomyces platensis subsp. malvinus. It is active against gram-positive bacteria. Synonyms: YL-704A3; YL 704A3; YL 704 A3; Leucomycin A3; Turimycin A5; Kitasamycin A3; Josamycine. Grade: 95%. CAS No. 16846-24-5. Molecular formula: C42H69NO15. Mole weight: 828. |  |
| Josamycin | A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. Alternative Names: Iosalide;Vilprafen;Leucomycin A3;EN 141. CAS No. 16846-24-5. Purity: 98%. Product ID: ACM16846245. Molecular formula: C42H69NO15. Mole weight: 827.99. IUPAC Name: josamycin. ECNumber: 240-871-6. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Josamycin Deisovaleryl Impurity | Josamycin Deisovaleryl Impurity. Uses: For analytical and research use. CAS No. 31642-61-2. Molecular formula: C37H61NO14. Mole weight: 743.89. Catalog: APB31642612. |  |
| Josamycin EP Impurity A | Josamycin EP Impurity A. Uses: For analytical and research use. CAS No. 18361-46-1. Molecular formula: C41H67NO15. Mole weight: 813.98. Catalog: APB18361461. | |
| Josamycin EP Impurity B | Josamycin EP Impurity B. Uses: For analytical and research use. CAS No. 40361-41-9. Molecular formula: C42H71NO15. Mole weight: 830.02. Catalog: APB40361419. | |
| Josamycin EP Impurity D | Josamycin EP Impurity D. Uses: For analytical and research use. CAS No. 22340-94-9. Molecular formula: C42H69NO15. Mole weight: 828.01. Catalog: APB22340949. | |
| Josamycin EP Impurity E | Josamycin EP Impurity E. Uses: For analytical and research use. CAS No. 40615-47-2. Molecular formula: C43H71NO15. Mole weight: 842.03. Catalog: APB40615472. | |
| Josamycin EP Impurity F | Josamycin EP Impurity F. Uses: For analytical and research use. Molecular formula: C35H59NO13. Mole weight: 701.85. Catalog: APB10552. | |
| Josamycin EP Impurity G | Josamycin EP Impurity G. Uses: For analytical and research use. Molecular formula: C37H61NO14. Mole weight: 743.89. Catalog: APB10553. | |
| Josamycin EP Impurity H | Josamycin EP Impurity H. Uses: For analytical and research use. Molecular formula: C40H67NO14. Mole weight: 785.97. Catalog: APB10555. | |
| Josamycin EP Impurity I | Josamycin EP Impurity I. Uses: For analytical and research use. Molecular formula: C38H63NO14. Mole weight: 757.92. Catalog: APB10554. | |
| Josamycin EP Impurity J | Josamycin EP Impurity J. Uses: For analytical and research use. Molecular formula: C43H71NO15. Mole weight: 842.03. Catalog: APB10556. | |
| Josamycin EP Impurity K | Josamycin EP Impurity K. Uses: For analytical and research use. Molecular formula: C40H65NO15. Mole weight: 799.95. Catalog: APB10557. | |
| Josamycin hydrochloride | Josamycin hydrochloride. Alternative Names: Josamycin HCl. CAS No. 11033-19-5. Purity: 98%. Product ID: ACM11033195. Molecular formula: C42H70ClNO15. Mole weight: 864.46. Alfa Chemistry - ISO 9001:32057 Certified. | |
| JP104 | JP104, a aryl carbamate, is an irreversible FAAH inhibitor with a pIC50 of ~8[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 887264-45-1. Pack Sizes: 5 mg. Product ID: HY-121558. | |
| JP-11646 | JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 (IC50 = 0.5 nM). JP11646 is freely reversible and ATP non-competitive. JP-11646 results in a decrease of PIM1, 2, and 3 mRNA. JP-11646 can effectively inhibit cell viability in small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas of the lung (LCNEC). JP-11646 can cause a decrease in p-4EBP-1 protein, increasing the cleavage of caspases while decreasing caspase-3. JP-11646 induces apoptosis or necroptosis in cells. JP-11646 leads to reductions in MYC paralogs. JP-11646 can be used for the study of SCLC, LCNEC, human acute leukemia (AML), multiple myeloma (MM), and triple-negative breast cancer (TNBC)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1902983-63-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115590. | |
| JP 1302 dihydrochloride | JP 1302 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1259314-65-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JP1302 dihydrochloride | JP1302 dihydrochloride is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 dihydrochloride shows antidepressant and antipsychotic-like effects. JP1302 dihydrochloride can be used for neuropsychiatric disorders and renal dysfunction research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259314-65-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103213. | |
| JP-153 | JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802937-26-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120417. | |
| JP-163-16 | JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-κB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL). (Pink: RelA/p65 Ligand (HY-174865); Blue: CRBN Ligand (HY-A0003); Black: Linker; CRBN Ligand+Linker (HY-160241))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3100147-70-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-174864. | |
| JPC0323 | JPC0323 is a dual 5-HT2C/5-HT2A receptor positive allosteric modulator. JPC0323 has on-target properties, acceptable plasma exposure and brain penetration. JPC0323 can be used for the research of neurological disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5972-45-2. Pack Sizes: 1 mg. Product ID: HY-155672. | |
| JPE-1375 | JPE-1375 is a complement C5a receptor 1 (C5aR1) antagonist. JPE-1375 effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 μM) and reduces TNF levels (EC50=4.5 μM) in mice. JPE-1375 can be used in studies of autoimmune and inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254036-23-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148141. | |
| JPH203 | JPH203 Inhibitor. Uses: Scientific use. Product Category: TQ0081. CAS No. 1037592-40-7. |  |
| JPH203 (Nanvuranlat) | Nanvuranlat (JPH203, KYT-0353), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 μM) and cell growth (IC50=4.1 μM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells. Group: Inhibitors. Alternative Names: KYT-0353. CAS No. 1037592-40-7. Pack Sizes: 5mg. Product ID: S8667. Formula: C23H19Cl2N3O4. Smiles: C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| JPM-OEt | JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 262381-84-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102087. | |
| JPS036 | JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2669785-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-145819. | |
| JQ1 | JQ1 Inhibitor. Uses: Scientific use. Product Category: T2110. CAS No. 1268524-70-4. | |
| JQ-1-Azidopropylamine | JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2915642-70-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174995. | |
| JQ-1 carboxylic acid | JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4. Uses: Scientific research. Category: Signaling pathways. CAS No. 202592-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-78695. | |
| JQ-1 carboxylic acid-PEG3-C2-NH2 | JQ-1 carboxylic acid-PEG3-C2-NH2 is a E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACT[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2098790-24-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169150. | |
| JQ1 Enantiomers Set ((S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, SGCBD01, BRD2 Inhibitor III, BRD3 Inhibitor II, BRD4 Inhibitor III, BRD6 Inhibitor I, BRDT Inhibitor I) | A cell-permeable I-BET class of thienodiazepine derivative whose (S)-(+), but not (R)-(-), enantiomer is shown to target both bromodomains (BD1 & BD2) of BET family members BRD2, BRD3, BRD4, and BRD6/BRDT in a Kac- (epsilon-N-acetylated lysine) competitive manner, exhibiting little affinity toward 23 other BD-containing proteins, BRD1 and BRD9, and little or no activity against a panel of more than 50 receptors, ion channels, and transporters. Effectively inhibits the oncogenic BRD4-NUT fusion-dependent NUT midline carcinoma and c-Myc oncoprotein-dependent multiple myeloma proliferation both in cultures (IC50 <1uM) in vitro and in mice (50mg/kg/day i.p.) in vivo. Also reported to cross the blood-testis boundary in male mice and effectively block BRDT-mediated spermatogenesis without affecting hormone levels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1set. US Biological Life Sciences. | Worldwide |
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