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| Product | Description | |
|---|---|---|
| JNK Inhibitor III, Cell-Permeable | The JNK Inhibitor III, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. |  |
| JNK Inhibitor III, Cell-Permeable, Negative Control | The JNK Inhibitor III, Cell-Permeable, Negative Control controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor II, Negative Control - CAS 54642-23-8 | The JNK Inhibitor II, Negative Control, also referenced under CAS 54642-23-8, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor I, (L)-Form, Cell-Permeable | The JNK Inhibitor I, (L)-Form, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control | The JNK Inhibitor I, (L)-Form, Cell-Permeable, Negative Control controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor IX | JNK inhibitor IX is a selective and potent JNK inhibitor with pIC50 of 6.5 and 6.7 for JNK2 and JNK3, respectively. Synonyms: TCS JNK 5a, TCS-JNK-5a, JNK Inhibitor IX, SC-202671, SC 202671, SC202671. Grades: >98%. CAS No. 312917-14-9. Molecular formula: C20H16N2OS. Mole weight: 332.42. |  |
| JNK Inhibitor IX - CAS 312917-14-9 | The JNK Inhibitor IX, also referenced under CAS 312917-14-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor V - CAS 345987-15-7 | The JNK Inhibitor V, also referenced under CAS 345987-15-7, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor VIII | JNK Inhibitor VIII (TCS JNK 6o) is a c-Jun N-terminal kinases (JNK-1, -2, and -3) inhibitor with Ki values of 2 nM, 4 nM, 52 nM, respectively, and has IC50 values of 45 nM and 160 nM for JNK-1 and -2, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TCS JNK 6o. CAS No. 894804-07-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-107598. |  |
| JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable | The JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor VI, TI-JIP153-163 | The JNK Inhibitor VI, TI-JIP153-163 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor X, BI-78D3 - CAS 883065-90-5 | The JNK Inhibitor X, BI-78D3, also referenced under CAS 883065-90-5, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor XI, BI-87G3 - CAS 2207-44-5 | The JNK Inhibitor XI, BI-87G3, also referenced under CAS 2207-44-5, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor XIII - CAS 40045-50-9 | The JNK Inhibitor XIII, also referenced under CAS 40045-50-9, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor XIV, SR-3306 | The JNK Inhibitor XIII, SR-3306 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor XVI, JNK-IN-8 | The JNK Inhibitor XVI, JNK-IN-8 controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor XVI, JNK-IN-8 ( (E) -3- (4- (dimethylamino) but-2-enamido) -N- (3-methyl-4- ( (4- (pyridin-3-yl) pyrimidin-2-yl) amino) phenyl) benzamide) | A cell-permeable, selective, and irreversible type 2 inhibitor of c-Jun N-terminal kinases (JNK) (IC50=4.67nM, 18.7nM, 980pM for JNK1, JNK2, and JNK3, respectively). Forms a covalent adduct with the conserved cysteine residue (Cys116 in JNK1) and binds to JNK in an extended type 2 conformation. Blocks the phosphorylation of c-Jun in cells (EC50=486nM in HeLa cells; 338nM in A375 cells). Exhibits greater cellular specificity for JNK when compared to 40 other kinases screened using a cell-based assay. Shows weaker binding to KIT mutants (IC50=92nM for V559D and 56nM for T670I) and RIOK2 (120nM). Does not show any significant inhibitory activity against various other kinases, including ERK, p38, Akt, MSK, and RSK. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| JNK Inhibitor XV, IQ-1S | The JNK Inhibitor XV, IQ-1S controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| JNK Inhibitor XV, IQ-1S (11H-Indeno[1,2-b]quinoxalin-11-one oxime, sodium salt) | A cell-permeable indenoquinoxalinone-oxime (IQ) compound that acts as a potent, non-toxic, reversible, ATP-competitive, high-affinity inhibitor of JNK (=390, 360 and 87nM for JNK1, JNK2 and JNK3, respectively) with moderate selectivity over CK1d, PI 3-Ky, and MKNK2 (IC50=1.4, 1.2, and 1.8uM, respectively). Shown to reduce c-Jun-Ser63 phosphorylation, and block the production of LPS-induced TNF-a (IC50 = 250nM) and IL-6 (IC50=610nM) in MonoMac-6 monocytic cells and in human hPBMCs, respectively. Also shown to inhibit NF-kB/AP-1 reporter activity (IC50=1.8uM) in human THP1-Blue monocytic cells and diminish nitric oxide production in murine J774-A.1 macrophages (IC50=12.5uM). Exhibits favorable pharmacokinetics properties and efficiently reduces ovalbumin-induced CD+ T-cell immune inflammation in a murine delayed-type hypersensitivity model (12.5mg/kg, two per day dosage, i.p.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H?N?Ona, Primary Target: JNK1,2,3. US Biological Life Sciences. | Worldwide |
| JNU-0921 | JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-? and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161982. | |
| Jo-1 human | recombinant, expressed in E. coli, solution. Group: Fluorescence/luminescence spectroscopy. | |
| Jodfenphos | analytical standard. Group: Pesticides & metabolites standards. | |
| Jojoba Oil Golden | Jojoba Oil Golden. |  CA, FL & NJ |
| Jolkinolide B | Jolkinolide B. Group: Biochemicals. Grades: Plant Grade. CAS No. 37905-08-1. Pack Sizes: 10mg. Molecular Formula: C20H26O4, Molecular Weight: 330.42. US Biological Life Sciences. | Worldwide |
| Josamycin | A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Iosalide;Vilprafen;Leucomycin A3;EN 141. Appearance: light yellow powder. CAS No. 16846-24-5. Molecular formula: C42H69NO15. Mole weight: 827.99. Purity: 0.98. IUPACName: josamycin. Density: 1.2 g/cm³. ECNumber: 240-871-6. Product ID: ACM16846245. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Josamycin | Josamycin (EN-141) is an orally active macrolide antibiotic exhibiting antimicrobial activity against a wide spectrum of pathogens, such as bacteria. The dissociation constant K d from ribosome for Josamycin is 5.5 nM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: EN-141. CAS No. 16846-24-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-B1920. | |
| Josamycin | Josamycin is a main component of YL-704, a macrolide antibiotic complex isolated from Streptomyces platensis subsp. malvinus. It is active against gram-positive bacteria. Synonyms: YL-704A3; YL 704A3; YL 704 A3; Leucomycin A3; Turimycin A5; Kitasamycin A3; Josamycine. Grades: 95%. CAS No. 16846-24-5. Molecular formula: C42H69NO15. Mole weight: 828. | |
| Josamycin USP | Josamycin solution. Grades: USP. CAS No. 16846-24-5. Product ID: 8-01556. Molecular formula: C42H69NO15. Mole weight: 828. |  |
| JP104 | JP104 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor. JP104 is in the carbamate class with an IC50 of 7.3 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-undecynecarbamate. Grades: ≥98%. CAS No. 887264-45-1. Molecular formula: C25H30N2O3. Mole weight: 406.5. | |
| JP 1302 dihydrochloride | The hydrochloride salt form of JP 1302, which has been found to be an α2-adrenoceptor blocker and could probably be used for prevention or treatment of nephropathy. Synonyms: JP 1302 dihydrochloride; JP1302 dihydrochloride; JP-1302 dihydrochloride; N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride; N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine Hydrochloride (1:2). Grades: ≥99% by HPLC. CAS No. 1259314-65-2. Molecular formula: C24H24N4.2HCl. Mole weight: 441.40. | |
| JP 1302 dihydrochloride | JP 1302 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1259314-65-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor with an IC 50 of 1.6 nM in competitive activity-based protein profiling (ABPP) experiments [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 887264-44-0. Pack Sizes: 1 mg. Product ID: HY-111199. | |
| JP83 | JP83 is an irreversible fatty acyl amide hydrolase (FAAH) inhibitor. JP83 is in the carbamate class with an IC50 of 14 nM for the human recombinant enzyme when tested using radiolabeled oleamide as the substrate. Synonyms: 3'-Carbamoyl-biphenyl-3-yl-hexylphenylcarbamate. Grades: ≥98%. CAS No. 887264-44-0. Molecular formula: C26H28N2O3. Mole weight: 416.5. | |
| JPC-211 | JPC-211 is a selective dopamine D3 receptor agonist. Uses: Dopamine antagonists. Synonyms: JPC-211; JPC 211; JPC211; 234757-41-6(maleate); PNU-99194A free base;2,3-dihydro-5,6-dimethoxy-N,N-dipropyl- 1H-Inden-2-amine. Grades: 98%. CAS No. 82668-33-5. Molecular formula: C17H27NO2. Mole weight: 277.41. | |
| JPH203 | JPH203 is a potent and selective L-type amino acid transporter 1 (LAT1) inhibitor. It inhibits 14C-leucine uptake and cell growth in human colon cancer-derived HT-29 cells in vitro. It also inhibits 14C-leucine uptake in mouse renal proximal tubule cells expressing l-type amino acid transporter 1, and inhibits cell growth. It completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. It suppresses proliferation in cancer cell lines and is used for cancer research. It was developed by J-Pharma and in clinic phase 1 trials. Uses: Jph203 suppresses proliferation in cancer cell lines and is used for cancer research. Synonyms: KYT-0353;KYT0353;JPH-203; KYT 0353;JPH 203;(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid. Grades: >98 %. CAS No. 1037592-40-7. Molecular formula: C23H19Cl2N3O. Mole weight: 472.32. | |
| JPH203 | JPH203 Inhibitor. Uses: Scientific use. Product Category: TQ0081. CAS No. 1037592-40-7. |  |
| JPH203 dihydrochloride | JPH203 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1), which is highly expressed in many tumor cells. Study has shown that JPH203 inhibited L-leucine uptake, and increased apoptosis rates and formed DNA ladder in Saos2 cells. Synonyms: KYT 0353; O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride; (2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride. Grades: ≥96% by HPLC. CAS No. 1597402-27-1. Molecular formula: C23H19Cl2N3O4·2HCl. Mole weight: 545.24. | |
| JQ1 | JQ1 Inhibitor. Uses: Scientific use. Product Category: T2110. CAS No. 1268524-70-4. | |
| JQ-1 (carboxylic acid) | JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4. Uses: Scientific research. Group: Signaling pathways. CAS No. 202592-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-78695. | |
| JQ1 Enantiomers Set ((S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, SGCBD01, BRD2 Inhibitor III, BRD3 Inhibitor II, BRD4 Inhibitor III, BRD6 Inhibitor I, BRDT Inhibitor I) | A cell-permeable I-BET class of thienodiazepine derivative whose (S)-(+), but not (R)-(-), enantiomer is shown to target both bromodomains (BD1 & BD2) of BET family members BRD2, BRD3, BRD4, and BRD6/BRDT in a Kac- (epsilon-N-acetylated lysine) competitive manner, exhibiting little affinity toward 23 other BD-containing proteins, BRD1 and BRD9, and little or no activity against a panel of more than 50 receptors, ion channels, and transporters. Effectively inhibits the oncogenic BRD4-NUT fusion-dependent NUT midline carcinoma and c-Myc oncoprotein-dependent multiple myeloma proliferation both in cultures (IC50 <1uM) in vitro and in mice (50mg/kg/day i.p.) in vivo. Also reported to cross the blood-testis boundary in male mice and effectively block BRDT-mediated spermatogenesis without affecting hormone levels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1set. US Biological Life Sciences. | Worldwide |
| JQEZ5 | JQEZ5 is a potent and selective inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM). JQEZ5 is developed for the treatment of some cancers in which EZH2 is overexpressed, such as non-small cell lung carcinoma (NSCLC). Synonyms: N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylpyrazolo[3,4-b]pyridine-4-carboxamide. Grades: ≥98%. CAS No. 1913252-04-6. Molecular formula: C30H38N8O2. Mole weight: 542.68. | |
| JQKD82 HCl | JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50=0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JQKD82 HCl; JQKD82 hydrochloride; JQKD82; JQKD-82; JQKD 82; PCK82; PCK-82; PCK 82. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2410512-38-6. Molecular formula: C27H43Cl3N4O5. Mole weight: 610.01. Purity: >98%. IUPACName: 2,4-diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate trihydrochloride. Canonical SMILES: O=C(OC1=CC=C(OC(C)C)C=C1OC(C)C)C2=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C2.[H]Cl.[H]Cl.[H]Cl. Product ID: ACM2410512386. Alfa Chemistry ISO 9001:2015 Certified. | |
| JR14a | JR14a is a potent thiophene antagonist of human complement C3a receptor. JR14a shows selectivity for the human C3a receptor over C5a receptor. JR14a can suppress C3aR-mediated inflammation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411440-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138161. | |
| JR-AB2-011 | JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 ?M. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 ?M)[1].JR-AB2-011 decreases the phosphorylation level of Akt, decreases MMP2 activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411853-34-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122022. | |
| JS11 | JS11 is an inhibitor for natriuretic polypeptide receptor 1 ( Npr1 ) with an IC 50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394592-04-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153650. | |
| JS25 | JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC 50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitts lymphoma. JS25 effectively crosses the blood-brain barrier [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2411771-95-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151808. | |
| JS6 | JS6 is a Bcl3 inhibitor, and inhibits Bcl3-NF-kB1 binding. JS6 inhibits tumor cell growth in vitro and in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 950244-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152177. | |
| JSH-150 | JSH-150 Inhibitor. Uses: Scientific use. Product Category: T8484. CAS No. 2247481-21-4. | |
| JSH-23 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| JSH-23 | JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. JSH-23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear translocation of p65/p50 subunit was inhibited by JSH-23 treatment in the sciatic nerve. The treatment also lowered the elevated IL-6, TNF-α, cyclo-oxygenase (COX-2) and inducible nitric oxide synthase (iNOS) levels/expression, indicating reduction in the inflammatory damage of the sciatic nerve. Apart from these effects, JSH-23 also increased Nrf2 and hemeoxygenase-1 (HO-1) levels which could imply its potential in increasing the strength of antioxidant defence. Synonyms: JSH-23; JSH 23; JSH23. Grades: 0.98. CAS No. 749886-87-1. Molecular formula: C16H20N2. Mole weight: 240.35. | |
| JSH-23 | JSH-23 is an NF-?B inhibitor which inhibits NF-?B transcriptional activity with an IC50 of 7.1 ?M in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-?B p65 without affecting I?B? degradation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 749886-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-13982. | |
| JS-K | ?97%. Group: Fluorescence/luminescence spectroscopy. | |
| JT001 sodium | JT001 (NLRP3-IN-19) sodium is a potent, specific and orally active inhibitor of NLRP3. JT001 sodium can inhibit NLRP3 inflammasome assembly, resulting in the inhibition of cytokine release and the prevention of pyroptosis. JT001 sodium can be used for the research of nonalcoholic steatohepatitis and liver fibrosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NLRP3-IN-19 sodium. CAS No. 2238820-09-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156034A. | |
| JT002 | JT002 is an orally active and selective NLRP3 inflammasome assembly inhibitor. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1?, IL-1?, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice. JT002 can be used for the study of a variety of inflammatory diseases, such as Muckle-Wells syndrome (MWS)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2238820-43-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149478. | |
| JT010 | JT010 is a covalent and site-selective TRPA1 agonist. JT010 can be used in myocardial infarction research[1][2][3][4][5][6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 917562-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111132. | |
| JT010 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JT010 | JT010 is a TRPA1 channel activator (EC50 = 0.65 nM) with potent selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM). It activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Synonyms: 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide. Grades: ≥98% by HPLC. CAS No. 917562-33-5. Molecular formula: C16H19ClN2O3S. Mole weight: 354.85. | |
| JTC 801 | JTC 801. Group: Biochemicals. Grades: Purified. CAS No. 244218-51-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| JTC-801 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and &mu. It is an opioid analgesic drug used in scientific research. Synonyms: JTC-801; JTC 801; JTC801. Grades: >98%. CAS No. 244218-51-7. Molecular formula: C26H25N3O2.HCl. Mole weight: 447.96. | |
| JTC-801 | JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a K i value of 8.2?nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 244218-51-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13274. | |
| JTE 013 | JTE 013. Group: Biochemicals. Grades: Purified. CAS No. 547756-93-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| JTE-013 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| JTE-013 | JTE-013 is a potent and selective sphingosine-1-phosphate (S1P) receptor 2 (S1P2) antagonist (IC50=17.6 nM). Synonyms: 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea; JTE-013; JTE 013; JTE013. Grades: >98%. CAS No. 383150-41-2. Molecular formula: C17H19Cl2N7O. Mole weight: 408.287. | |
| JTE-013 | JTE-013 is a potent and specific S1P 2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P 2 with IC 50 s of 17 nM and 22 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 383150-41-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-100675. | |
| JTE522 | JTE522, a selective COX-2 inhibitor, can induce apoptosis and inhibit cell proliferation in human endometrial cancer cell line RL95-2 cells and to explore the molecular mechanisms. Synonyms: 4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide; 4-(4-cyclohexyl-2-methyloxazol-5-yl)-2-fluorobenzenesulfonamide; JTE 522; JTE-522. CAS No. 180200-68-4. Molecular formula: C16H19FN2O3S. Mole weight: 338.4. | |
| JTE-607 | JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-?, IL-1?, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 188791-09-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110133. | |
| JTE 607 dihydrochloride | The hydrochloride salt form of JTE 607, which has been found to be a cytokine release inhibitor. Synonyms: JTE 607 dihydrochloride; JTE607 dihydrochloride; JTE-607 dihydrochloride; N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 188791-09-5. Molecular formula: C25H31Cl2N3O5.2HCl. Mole weight: 597.36. | |
| JTE-607 HCl | JTE-607, also known as TO-207, is a cytokine production inhibitor potentially for the treatment of systemic inflammatory response, and induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TO-207; TO 207; TO207; JTE-607; JTE 607; JTE 607; JTE-607 HCl; JTE-607 dihydrochloride. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 188791-09-5. Molecular formula: C25H33Cl4N3O5. Mole weight: 597.36. Purity: >98%. IUPACName: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride. Canonical SMILES: O=C(OCC)[C@H](CC1=CC=CC=C1)NC(C2=CC(Cl)=C(OCCN3CCN(C)CC3)C(Cl)=C2O)=O.[H]Cl.[H]Cl. Product ID: ACM188791095. Alfa Chemistry ISO 9001:2015 Certified. | |
| JTE 907 | JTE 907. Group: Biochemicals. Grades: Purified. CAS No. 282089-49-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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