A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Lazabemide hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 103878-83-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Lazertinib
Lazertinib (YH25448; GNS-1480) is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YH25448; GNS-1480. CAS No. 1903008-80-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-109061.
Lazertinib mesylate
Lazertinib (YH25448; GNS-1480) mesylate is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib mesylate exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib mesylate induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib mesylate competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib mesylate is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YH25448 mesylate; GNS-1480 mesylate. CAS No. 2247995-37-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109061B.
L-Azetidine-2-carboxylic acid
L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2133-34-8. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-W050044.
L-Azetidine-2-carboxylic acid
Endogenous metabolites; Specific proline antagonist; intermediates in synthesis of abnormally high molecular weight polypeptides. Synonyms: (S)-2-Azetidine-2-carboxylic acid. Grade: ≥ 97% (Assay). CAS No. 2133-34-8. Molecular formula: C4H7NO2. Mole weight: 101.10.
L-Azetidine-2-carboxylic Acid
A four-membered ring analog of L-Proline. A useful intermediate in the synthesis of polypeptides. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
L-Azetidine-2-carboxylic acid 98+%
L-Azetidine-2-carboxylic acid 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
L-Azetidine-2-carboxylic Acid t-Butyl Ester
A protected four-membered ring analog of L-Proline. A useful intermediate in the synthesis of polypeptides. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
L-Azidohomoalanine
L-Azidohomoalanine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences.
L-Azidohomoalanine-[1,2,3,4-13C4,2,4-15N2] Hydrochloride is a labelled salt of L-Azidohomoalanine. L-Azidohomoalanine is a metabolite of methionine. Synonyms: L-Azidohomoalanine-[13C4,15N2] Hydrochloride. Grade: 98% by CP; 99% atom 13C; 98% atom 15N. Molecular formula: [13C]4H9ClN2[15N]2O2. Mole weight: 186.55.
L-Azidohomoalanine hydrochloride
L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 942518-29-8. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-140346A.
L-Azidonorleucine hydrochloride
L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants [1][2]. L-Azidonorleucine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454334-76-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-131033.
LB-100
LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1632032-53-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18597.
LB-100
LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. Group: Inhibitors. CAS No. 1632032-53-1. Pack Sizes: 5mg. Product ID: S7537. Formula: C13H20N2O4. Smiles: CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3. Storage Conditions: 2 years -80 in solvent.
United States; Europe
LB244
LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases. The pharmacokinetic properties of LB244 indicate limited oral activity in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3074622-05-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156117.
LB 42708
LB 42708. Group: Biochemicals. Grades: Purified. CAS No. 226929-39-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
L-Balenine Hydrochloride
L-Balenine Hydrochloride is an imidazole dipeptide found in the dorsal muscle and amino acid composition in body parts of whales. Synonyms: Na-(3-aminopropanoyl)-Nt-methyl-L-histidine Hydrochloride; Balenine Hydrochloride; L-N-β-Alanyl-1-methylhistidine Hydrochloride; β-Alanyl-1-methyl-L-histidine Hydrochloride; N-β-Alanyl-1-methyl-L-histidine Hydrochloride; L-Histidine, β-alanyl-1-methyl-, hydrochloride (1:1). Grade: ≥95%. Molecular formula: C10H16N4O3.HCl. Mole weight: 276.72.
LB Broth (Lennox)
1kg Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials. Formula: N/A. Prepack ID 90005407-1kg. See USA prepack pricing.
LB Broth (Miller)
1kg Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials. Formula: N/A. Prepack ID 85075651-1kg. See USA prepack pricing.
L-b-Chloroalanine, Methyl Ester, Hydrochloride
L-b-Chloroalanine, Methyl Ester, Hydrochloride. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
L- β, β-Diethylalanine
L- β, β-Diethylalanine. Group: Biochemicals. Alternative Names: L-3-Ethylnorvaline; L-2-Amino-3-ethylpentanoic Acid; L-3-Ethyl-norvaline; S-Ethylnorvaline. Grades: Highly Purified. CAS No. 14328-49-5. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
L-β-Ethynylserine
L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65207-64-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164745.
L-beta-Homoisoleucine hydrochloride. Group: Biochemicals. Alternative Names: L-b-HomoIle-OH·HCl; (3R,4S)-3-Amino-4-methylhexanoic acid hydrochloride. Grades: Highly Purified. CAS No. 219310-10-8. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
Worldwide
L-β-Homoleucine
L-β-Homoleucine is an amino acid analogue used in the field of organic chemistry and biochemistry for its role in peptide and protein modification studies. Synonyms: (S)-3-Amino-5-methyl-hexanoic acid; (S)-3-amino-5-methylhexanoic acid; H-β-homoLeu-OH; L-beta-homoleucine. Grade: 98%. CAS No. 22818-43-5. Molecular formula: C7H15NO2. Mole weight: 145.20.
L-beta-Homoleucine hydrochloride
L-beta-Homoleucine hydrochloride. Group: Biochemicals. Alternative Names: L-HomoLeu-OH·HCl. Grades: Highly Purified. CAS No. 96386-92-4. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
L-β-Imidazolelactic acid. Uses: For analytical and research use. CAS No. 14403-45-3. Molecular formula: C6H8N2O3. Mole weight: 156.14. Catalog: APB14403453.