A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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| Product | Description | |
|---|---|---|
| Maximizer DT Pro 64oz | Maximizer DT Pro is a commercial strength, Eco-friendly solution for keeping your grease traps and drains clean, running and clog-free. Powered by a unique blend of Class 1 organisms, enzymes, and bacteria, it breaks down organic waste safely and effectively, all without relying on caustics or harsh chemicals. Uses: Commerical and Industrial drain and grease trap cleaner. Grades: Technical. Pack Sizes: 64 oz, 2.5 gal case, 5 gal pail. |  USA |
| MaxiPost | MaxiPost. Group: Biochemicals. Grades: Purified. CAS No. 187523-35-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MAY0132 | MAY0132 is a potent and selective EPAC2 inhibitor with an IC50 of 0.4 μM. MAY0132 significantly inhibits replication of HMPV, AdV and RSV, reduces viral infection-induced cytokine/chemokine production, and inhibits NF-κB activation. MAY0132 has antiviral activity and can be used in the study of respiratory virus infection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1895861-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138956. |  |
| May-Grunwald Stain | May-Grunwald Stain. Uses: For analytical and research use. Catalog: APB12415. |  |
| Mayol® | Mayol®. CAS No. 13828-37-0. VIGON Item # 502811. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. |  America & Internationally |
| Mayosperse 60 | Mayosperse 60. CAS No. 31075-24-8. Molecular formula: C32H78Cl6N6O3. Mole weight: 807.7g/mol. IUPAC Name: 2-[dimethyl(propyl)azaniumyl]ethyl-[2-[2-[2-[2-[2-[2-[2-methoxyethyl(dimethyl)azaniumyl]ethyl-dimethylazaniumyl]ethoxy]ethyl-dimethylazaniumyl]ethyl-dimethylazaniumyl]ethoxy]ethyl]-dimethylazanium;hexachloride. SMILES: CCC[N+](C)(C)CC[N+](C)(C)CCOCC[N+](C)(C)CC[N+](C)(C)CCOCC[N+](C)(C)CC[N+](C)(C)CCOC.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]. InChI: InChI=1S/C32H78N6O3.6ClH/c1-15-16-33(2,3)17-18-35(6,7)24-29-40-31-26-37(10,11)21-22-38(12,13)27-32-41-30-25-36(8,9)20-19-34(4,5)23-28-39-14;;;;;;/h15-32H2,1-14H3;6*1H/q+6;;;;;;/p-6. |  |
| Maytansine | Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 153858. CAS No. 35846-53-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-13674. | |
| Maytansine | Maitansine, a cytotoxic agent, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. Synonyms: NSC153858; NSC-153858; NSC 153858; (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-acetyl-N-methyl-L-alaninate. Grade: ≥95%. CAS No. 35846-53-8. Molecular formula: C34H46ClN3O10. Mole weight: 692.2. |  |
| Maytansinoid DM4 | DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates. Uses: Adcs cytotoxin. Synonyms: N2'-deacetyl-n2'-(4-Mercapto-4-Methyl-1-oxopentyl)-6-MethylMaytansine. Grade: ≥98.0% (HPLC). CAS No. 799840-96-3. Molecular formula: C39H56ClN3O10S. Mole weight: 780.37. | |
| Maytansinoid DM4 | Maytansinoid DM4 is a cytotoxic agent. It is used as a antibody-drug conjugate that has a potential to treat cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 799840-96-3. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C39H56ClN3O10S, Molecular Weight: 794.39. US Biological Life Sciences. | Worldwide |
| Maytansinol | Maytansinol. Group: Biochemicals. Alternative Names: 3-O-De[2-[methyl(acetyl)amino]-1-oxopropyl]maytansine. Grades: Highly Purified. CAS No. 57103-68-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C28H37ClN2O8. US Biological Life Sciences. | Worldwide |
| Maytansinol | Maytansinol is an ansamacrolide isolated from P. verrucose. It was shown to inhibit microtubule assembly and induces microtubule disassembly in vitro. It exhibits antitumor activity. Synonyms: (3S)-3-O-De[2-(acetylmethylamino)-1-oxopropyl]-maytansine; Ansamitocin P-0; NSC239386; NSC-239386; Maytansine; Ansamitocin P 0; Antibiotic C 15003P; NSC 239386. Grade: 95%. CAS No. 57103-68-1. Molecular formula: C28H37ClN2O8. Mole weight: 565.06. | |
| Maytansinol | Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ansamitocin P-0. CAS No. 57103-68-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19474. | |
| MAZ51 | MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 163655-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116624. | |
| Mazdutide | Mazdutide is a long-acting synthetic peptide that functions as a dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR). Developed as a next-generation treatment for metabolic disorders, it is a specialized derivative of oxyntomodulin. By targeting both receptors, it offers a more comprehensive approach to managing metabolic health compared to traditional mono-agonists, making it a high-value molecule in pharmaceutical research and clinical development. Applications: Mazdutide is primarily utilized in the clinical development of therapeutic interventions for chronic weight management and type 2 diabetes mellitus. its unique ability to regulate both glucose levels and energy balance makes it a candidate for treating non-alcoholic fatty liver disease (nafld) and non-alcoholic steatohepatitis (nash). Category: Hypoglycemic apis. CAS No. 2259884-03-0. Product ID: API2259884030. Molecular formula: C210H322N46O67. Mole weight: 4563.14. InChIKey: XRBYWQZGSZWYEJ-HMQIFOERSA-N. Appearance: White powder. |  |
| Mazdutide | Mazdutide (IBI-362; LY-3305677) is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR). Mazdutide binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM). Mazdutide is used in studies of obesity and type 2 diabetes (T2D)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IBI-362; LY-3305677; OXM-3. CAS No. 2259884-03-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3375. | |
| Mazdutide | Mazdutide is a long-acting glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. Mazdutide has been use in the research of type 2 diabetes mellitus (T2DM). Synonyms: IBI362; IBI 362; IBI-362; LY3305677; LY 3305677; LY-3305677; OXM3; OXM-3; OXM 3. CAS No. 2259884-03-0. Molecular formula: C207H317N45O65. Mole weight: 4476. | |
| Mazisotine | Mazisotine (CNTX-0290) is an orally active, non-opioid somatostatin receptor 4 (SSTR4) agonist with an EC50 of 4.7 nM. Mazisotine exerts significant analgesic effects in various nociceptive (inflammatory, osteoarthritic) and neuropathic pain models. Mazisotine can be used for pain research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3556050; CNTX-0290. CAS No. 1638588-92-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139347. | |
| MB05032 | MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 261365-11-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16307. | |
| MB-07344 | MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852947-39-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19513. | |
| MB-07811 | MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VK-2809. CAS No. 852948-13-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-111288. | |
| MB710 | MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1 μM. MB710 shows anticancer activity in p53-Y220C cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230044-57-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120373. | |
| MBA-m1 | MBA-m1 is a MLKL inhibitor. MBA-m1 inhibits necroptosis in Mlkl-/- NIH-3T3 cells. MBA-m1 ameliorates disease in MLKL-induced dermatitis and abdominal aortic aneurysm mouse model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305866-70-0. Pack Sizes: 1 mg. Product ID: HY-24504. | |
| m-BBIG dihydrochloride | m-BBIG dihydrochloride is a member of Bis-iminoguanidine (BIG) family and can be utilized in synthetic chemistry[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 181147-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164652. | |
| MBCQ | MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ lacks inhibitory activity toward other PDE isozymes (all IC50s>100 μM). MBCQ dilates coronary arteries via specific inhibition of cGMP-PDE[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150450-53-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-114672. | |
| MBD | MBD (7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole), a new fluorescent probe for protein and nucleoprotein conformation, is applied to bacterial ribosomes and to bovine trypsinogen and trypsin. MBD is strongly fluorescent upon binding to a hydrophobic area of a macromolecule[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole. CAS No. 33984-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-141667. | |
| MBD-7 | MBD-7 is isolated from Mus musculus (Mouse) and has bactericidal activity. Synonyms: Beta-defensin 7; BD-7; Defensin, beta 7. | |
| m-Benzenedimethanol | Benzenedimethanol. CAS No. 626-18-6. Categories: 1,3-benzenedimethanol. |  Pennsylvania PA |
| m-(Benzyloxy)benzyl Chloride | m-(Benzyloxy)benzyl Chloride. Group: Biochemicals. Alternative Names: 1-Benzyloxy-3-chloromethylbenzene; 3-(Benzyloxy)benzyl Chloride; Benzyl α-Chloro-m-tolyl Ether. Grades: Highly Purified. CAS No. 24033-03-2. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| MBHA Resin | MBHA Resin. | |
| MBM-55 | MBM-55 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM. MBM-55 shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 (IC50=5.4 nM) and DYRK1a (IC50=6.5 nM). MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2083622-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101029. | |
| MBMAP28 | BMAP-28 has broad antimicrobial activities and confers protection in an animal model: mouse of bacterial infection or sepsis. | |
| M(Boc) Acetic acid | A nucleobase for PNA synthesis. Synonyms: (6-tert-butoxycarbonylaminopyridin-3-yl) acetic acid. Grade: 98%. CAS No. 1256337-02-6. Molecular formula: C12H16N2O4. Mole weight: 252.27. | |
| Mbo II | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (dam-) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme approximately 60% of the dna fragments can be ligated and recut. in presence of 10%peg ligation is better. Group: Restriction Enzymes. Purity: 200U; 1000U. GAAGA(N)8↑ CTTCT(N)7&darr. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries the cloned gene Mbo II from Moraxella bovis. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM NaCl; 0,1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1130RE. |  |
| MBP146-78 | MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases. Uses: Scientific research. Category: Signaling pathways. CAS No. 188343-77-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101525. | |
| MBP (85-106) guinea pig, MBP (86-107) human | MBP (85-106) guinea pig, MBP (86-107) human is a 85-106 fragment of the guinea pig, myelin basic protein (MBP) or 86-107 fragment of the human MBP. It is used in multiple sclerosis research. Synonyms: H-Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro-Ser-Gln-Gly-Lys-Gly-Arg-OH; Val-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro-Pro-Pro-Ser-Gln-Gly-Lys-Gly-Arg. Molecular formula: C113H180N34O28. Mole weight: 2463. | |
| MBP (85-99) peptide antagonist trifluoroacetate salt | MBP (85-99) peptide antagonist trifluoroacetate salt. Uses: For analytical and research use. CAS No. 444305-16-2 (free base). Mole weight: 1543.76 (free base basis). Catalog: ALP444305162. | |
| MBQ-167 | MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 2097938-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112842. | |
| MBS | DryPowder; PelletsLargeCrystals. Molecular formula: C11H12N2OS2. Mole weight: 252.4g/mol. IUPAC Name: 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine. SMILES: C1COCCN1SC2=NC3=CC=CC=C3S2. InChI: InChI=1S/C11H12N2OS2/c1-2-4-10-9(3-1)12-11(15-10)16-13-5-7-14-8-6-13/h1-4H,5-8H2. | |
| MBS | MBS. CAS No. 58626-38-3. Pack Sizes: Milligram Quantities: 100 mg. Order Number: CL202. |  www.prochemonline.com |
| MBTH | MBTH. CAS No. 38894-11-0. Categories: 2-hydrazono-3-methyl-2,3-dihydrobenzo[d]thiazole hydrochloride hydrate. | Pennsylvania PA |
| MBX-2982 | MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 1037792-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15291. | |
| MC-031 | MC-031, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 10.6×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: O-Demethylchlorothricin. CAS No. 134637-04-0. Molecular formula: C49H61ClO16. Mole weight: 941.45. | |
| MC-032 | MC-032, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 10.5×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: O-Demethylhydroxychlorothricin. CAS No. 134615-17-1. Molecular formula: C49H61ClO17. Mole weight: 957.45. | |
| MC-033 | MC-033, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 1.06×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: MC 033; Chlorothricin, 3B-O-de(3-chloro-6-methoxy-2-methylbenzoyl)-, 4B-(3-chloro-6-methoxy-2-methylbenzoate). CAS No. 134615-15-9. Molecular formula: C49H61ClO16. Mole weight: 941.45. | |
| MC-034 | MC-034, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 18.3×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: MC 034; Chlorothricin, 3B-O-de(3-chloro-6-methoxy-2-methylbenzoyl)-2A-hydroxy-, 4B-(3-chloro-6-methoxy-2-methylbenzoate). CAS No. 134615-16-0. Molecular formula: C49H61ClO17. Mole weight: 957.45. | |
| MC1568 | MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research. Uses: Scientific research. Category: Signaling pathways. CAS No. 852475-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16914. | |
| MC180295 | MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (rel)-MC180295. CAS No. 2237942-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119940. | |
| MC-1-F2 | MC-1-F2 is a FOXC2 inhibitor. MC-1-F2 shows a binding affinity (Kd) of 26 μM for full-length FOXC2. MC-1-F2 reduces epithelial-mesenchymal transition (EMT) markers in breast cancer cells, suppresses cancer stem cell (CSC) properties and reduces invasiveness in castration-resistant prostate cancer (CRPC) cells. MC-1-F2 can be used for the study of CRPC and breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376894-10-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149894. | |
| MC3138 | MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1844889-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160818. | |
| MC3482 | MC3482 is a specific sirtuin5 (SIRT5) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922280-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112587. | |
| MC4171 | MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 μM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034769-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153604. | |
| MC70 | MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 μM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1031367-64-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113805. | |
| MC903 (Calcipotriene) | Calcipotriene (MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: Calcipotriol. CAS No. 112965-21-6. Pack Sizes: 5mg. Product ID: S3739. Formula: C27H40O3. Smiles: CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C. Storage Conditions: 2 years -80 in solvent (in dark and seal) . |  United States; Europe |
| MCA | MCA (7-Methoxycoumarin-4-acetic acid) is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Methoxycoumarin-4-acetic acid. CAS No. 62935-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-W027544. | |
| MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin | MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414594-29-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132158. | |
| Mca-(ala7,lys(dnp)9)-bradykinin | Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 323577-36-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3749. | |
| Mca-(Ala7,Lys(Dnp)9)-Bradykinin | Mca-(Ala7,Lys(Dnp)9)-Bradykinin is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), a membrane-bound zinc metallopeptidase related to neprilysin in amino acid sequence. It is used as a substrate for insulin-degrading enzymes (IDE) and ACE2. Synonyms: Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH; N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine; (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl); N2-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine. Grade: 95%. CAS No. 323577-36-2. Molecular formula: C66H81N15O19. Mole weight: 1388.44. | |
| Mca-Ala-Pro-Lys(Dnp)-OH | Mca-Ala-Pro-Lys(Dnp)-OH, a FRET substrate for angiotensin-converting enzyme 2 (ACE2), is used to monitor enzyme activity in plasma, urine, heart and lungs. Synonyms: Mca-APK(Dnp); L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-L-lysine; (S)-6-((2,4-dinitrophenyl)amino)-2-((S)-1-((S)-2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)propanoyl)pyrrolidine-2-carboxamido)hexanoic acid. Grade: ≥95%. CAS No. 305336-82-7. Molecular formula: C32H36N6O12. Mole weight: 696.67. | |
| Mca-Ala-Pro-Lys(Dnp)-OH | Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305336-82-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2536. | |
| Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide | Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide, a fluorescent (FRET) peptide substrate containing the wild-type amyloid precursor protein (APP) β-secretase cleavage site, is used to determine the β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). TOP is a potential β-secretase candidate and is involved in APP processing in vivo. Synonyms: Mca-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide; Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2; Mca-SEVKMDAEFRK(Dnp)RR-amide. Grade: ≥95% by HPLC. CAS No. 1802078-33-6. Molecular formula: C87H129N27O28S. Mole weight: 2033.21. | |
| Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2, the FRET substrate, is hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M-1s-1) than by interstitial collagenase (MMP-1). However, it shows little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M-1s-1), and gelatinase B (MMP-9) (kcat/Km = 55300 M-1s-1). This fluorogenic substrate is digested by Metalloelastase (MMP-12) with a kcat/Km of 243000 M-1s-1. Synonyms: NFF-2; 7-Methoxycoumarin-4-acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-(2,4-dinitrophenyl)Lys amide; N2-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-L-lysinamide. Grade: ≥95%. CAS No. 158584-08-8. Molecular formula: C79H105N19O19S. Mole weight: 1656.86. | |
| Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) is a pro-memapsin-2 fluorogenic substrate (FRET) containing the β-secretase site of the Swedish mutation of APP, SEVNLDAEF. Synonyms: Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp); Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine; L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-. Grade: ≥95%. CAS No. 1802078-31-4. Molecular formula: C68H88N14O27. Mole weight: 1533.53. | |
| Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide is a fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP. Its kinetic parameters at pH 4.5 are Km = 4.5 μM and kcat = 0.25 min-1. Synonyms: Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp) amide; Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-NH2; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysinamide; L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-; Mca-SEVNLDAEFK(Dnp) amide. Grade: ≥95%. CAS No. 1802078-32-5. Molecular formula: C68H89N15O26. Mole weight: 1532.54. | |
| Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human) | Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human), a fluorogenic (FRET) peptide substrate, is used for the tumor necrosis factor (TNF) converting enzyme (TACE, ADAM-17 endopeptidase). Synonyms: Mca-(endo-1a-Dap(Dnp))-TNF-a (-5 to +6) amide (human); Mca-Pro-Leu-Ala-Gln-Ala-Val-Dap(Dnp)-Arg-Ser-Ser-Ser-Arg-NH2; L-Argininamide, 1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl-; 1-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl-L-argininamide. Grade: ≥95% by HPLC. CAS No. 192723-42-5. Molecular formula: C69H103N23O24. Mole weight: 1638.72. | |
| Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 | Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2, a FRET substrate for cathepsin D and E, is also cleaved by napsin A. Synonyms: MOCAc-GKPILFFRL-{Lys(Dnp)}-{D-Arg}-NH2; Mca-GKPILFFRL-Dpa-r-amide; MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-{Lys(Dnp)}-{D-Arg}-NH2; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-(2,4-dinitrophenyl)-L-lysyl-D-argininamide; D-Argininamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-(2,4-dinitrophenyl)-L-lysyl-; Cathepsin D and E FRET Substrate. Grade: ≥90%. CAS No. 839730-93-7. Molecular formula: C85H122N22O19. Mole weight: 1756.01. | |
| Mca-KPLGL-Dap(Dnp)-AR-NH2 | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1[1]. (Ex/Em=325 nm/400 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 720710-69-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4931. | |
| MC-Ala-Ala-PAB | MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1949793-44-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148464. | |
| MCA-Lys-Leu-Lys(Dnp) | MCA-Lys-Leu-Lys(Dnp). Synonyms: N6-(2,4-dinitrophenyl)-N2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)-L-lysyl-L-leucyl-L-lysine. Molecular formula: C36H47N7O12. Mole weight: 769.81. | |
| Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 | Mca-KPLGL-Dpa-AR-NH2 is an N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH2 with a Lys yields a fluorogenic peptide with improved substrate properties. Compared with Mca-PLGL-Dpa-AR-NH2, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate Mca-KPLGL-Dpa-AR-NH2 for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased by 2-9 times and 3 times, respectively, while those for gelatinases and matrilysin remain equally high. Synonyms: L-Argininamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-; N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-L-argininamide; MMPs substrate Fluorogenic. Grade: ≥95%. CAS No. 720710-69-0. Molecular formula: C55H80N16O16. Mole weight: 1221.32. | |
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