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| Product | Description | |
|---|---|---|
| MBX-2982 | MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 1037792-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15291. |  |
| MC-031 | MC-031, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 10.6×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: O-Demethylchlorothricin. CAS No. 134637-04-0. Molecular formula: C49H61ClO16. Mole weight: 941.45. |  |
| MC-032 | MC-032, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 10.5×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: O-Demethylhydroxychlorothricin. CAS No. 134615-17-1. Molecular formula: C49H61ClO17. Mole weight: 957.45. | |
| MC-033 | MC-033, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 1.06×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: MC 033; Chlorothricin, 3B-O-de(3-chloro-6-methoxy-2-methylbenzoyl)-, 4B-(3-chloro-6-methoxy-2-methylbenzoate). CAS No. 134615-15-9. Molecular formula: C49H61ClO16. Mole weight: 941.45. | |
| MC-034 | MC-034, an inhibitor of cholesterol biosynthesis, is produced by the strain of Streptomyces sp. A3761. It inhibited the synthesis of cholesterol from Mevalonic acid with IC50 of 18.3×10-5 mol/L. It also showed weak anti-gram-positive bacteria activity and inhibited the growth of HL-60 cells. Synonyms: MC 034; Chlorothricin, 3B-O-de(3-chloro-6-methoxy-2-methylbenzoyl)-2A-hydroxy-, 4B-(3-chloro-6-methoxy-2-methylbenzoate). CAS No. 134615-16-0. Molecular formula: C49H61ClO17. Mole weight: 957.45. | |
| MC 1443 | MC 1443. Group: Biochemicals. Alternative Names: 6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole. Grades: Highly Purified. CAS No. 163239-22-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C15H11FN2. US Biological Life Sciences. |  Worldwide |
| MC1568 | MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research. Uses: Scientific research. Category: Signaling pathways. CAS No. 852475-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16914. | |
| MC 1568 | A selective class II (IIa) histone deacetylase (HDAC II) inhibitor. It exhibits tissue-selective inhibition between members of class II acetylases in vivo, particularly in skeletal muscle and the heart. It arrests myogenesis through the stabilization of myocyte enhancer factor 2D (MEF2D)-HDAC3/4 complex. Group: Biochemicals. Alternative Names: 3-[4-(3-(3-Fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide. Grades: Highly Purified. CAS No. 852475-26-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MC180295 | MC180295 ((rel)-MC180295) is a potent and selective CDK9-Cyclin T1 inhibitor, with an IC50 of 5 nM, at least 22-fold more selective for CDK9 over other CDKs. MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (rel)-MC180295. CAS No. 2237942-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119940. | |
| MC-1-F2 | MC-1-F2 is a FOXC2 inhibitor. MC-1-F2 shows a binding affinity (Kd) of 26 μM for full-length FOXC2. MC-1-F2 reduces epithelial-mesenchymal transition (EMT) markers in breast cancer cells, suppresses cancer stem cell (CSC) properties and reduces invasiveness in castration-resistant prostate cancer (CRPC) cells. MC-1-F2 can be used for the study of CRPC and breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376894-10-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149894. | |
| MC3138 | MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1844889-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160818. | |
| MC3482 | MC3482 is a specific sirtuin5 (SIRT5) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922280-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112587. | |
| MC4171 | MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 μM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034769-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153604. | |
| MC70 | MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 μM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1031367-64-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113805. | |
| MC903 (Calcipotriene) | Calcipotriene (MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.Solutions are unstable and should be fresh-prepared. Group: Inhibitors. Alternative Names: Calcipotriol. CAS No. 112965-21-6. Pack Sizes: 5mg. Product ID: S3739. Formula: C27H40O3. Smiles: CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C. Storage Conditions: 2 years -80 in solvent (in dark and seal) . |  United States; Europe |
| MCA | MCA (7-Methoxycoumarin-4-acetic acid) is a Coumarin (HY-N0709) derivative. MCA quantitates platelet-activating factor (PAF) by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Methoxycoumarin-4-acetic acid. CAS No. 62935-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-W027544. | |
| MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin | MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414594-29-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132158. | |
| Mca-(ala7,lys(dnp)9)-bradykinin | Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 323577-36-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3749. | |
| Mca-(Ala7,Lys(Dnp)9)-Bradykinin | Mca-(Ala7,Lys(Dnp)9)-Bradykinin is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1), a membrane-bound zinc metallopeptidase related to neprilysin in amino acid sequence. It is used as a substrate for insulin-degrading enzymes (IDE) and ACE2. Synonyms: Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH; N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine; (7-methoxycoumarin-4-yl)acetyl-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys-(2,4-dinitrophenyl); N2-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-alanyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine. Grade: 95%. CAS No. 323577-36-2. Molecular formula: C66H81N15O19. Mole weight: 1388.44. | |
| Mca-Ala-Pro-Lys(Dnp)-OH | Mca-Ala-Pro-Lys(Dnp)-OH, a FRET substrate for angiotensin-converting enzyme 2 (ACE2), is used to monitor enzyme activity in plasma, urine, heart and lungs. Synonyms: Mca-APK(Dnp); L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-L-lysine; (S)-6-((2,4-dinitrophenyl)amino)-2-((S)-1-((S)-2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamido)propanoyl)pyrrolidine-2-carboxamido)hexanoic acid. Grade: ≥95%. CAS No. 305336-82-7. Molecular formula: C32H36N6O12. Mole weight: 696.67. | |
| Mca-Ala-Pro-Lys(Dnp)-OH | Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305336-82-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2536. | |
| Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide | Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide, a fluorescent (FRET) peptide substrate containing the wild-type amyloid precursor protein (APP) β-secretase cleavage site, is used to determine the β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). TOP is a potential β-secretase candidate and is involved in APP processing in vivo. Synonyms: Mca-APP770 (667-676)-Lys(Dnp)-Arg-Arg amide; Mca-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2; Mca-SEVKMDAEFRK(Dnp)RR-amide. Grade: ≥95% by HPLC. CAS No. 1802078-33-6. Molecular formula: C87H129N27O28S. Mole weight: 2033.21. | |
| Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 | Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2, the FRET substrate, is hydrolyzed 60 times more rapidly by stromelysin 1 (MMP-3) (kcat/Km= 59400 M-1s-1) than by interstitial collagenase (MMP-1). However, it shows little discrimination between MMP-3, gelatinase A (MMP-2) (kcat/Km= 54000 M-1s-1), and gelatinase B (MMP-9) (kcat/Km = 55300 M-1s-1). This fluorogenic substrate is digested by Metalloelastase (MMP-12) with a kcat/Km of 243000 M-1s-1. Synonyms: NFF-2; 7-Methoxycoumarin-4-acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-(2,4-dinitrophenyl)Lys amide; N2-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-tyrosyl-L-alanyl-L-norvalyl-L-tryptophyl-L-methionyl-N6-(2,4-dinitrophenyl)-L-lysinamide. Grade: ≥95%. CAS No. 158584-08-8. Molecular formula: C79H105N19O19S. Mole weight: 1656.86. | |
| Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) is a pro-memapsin-2 fluorogenic substrate (FRET) containing the β-secretase site of the Swedish mutation of APP, SEVNLDAEF. Synonyms: Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp); Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine; L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-. Grade: ≥95%. CAS No. 1802078-31-4. Molecular formula: C68H88N14O27. Mole weight: 1533.53. | |
| Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide | Mca-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (667-675)-Lys(Dnp) amide is a fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP. Its kinetic parameters at pH 4.5 are Km = 4.5 μM and kcat = 0.25 min-1. Synonyms: Mca-(Asn670,Leu671)-APP770 (667-675)-Lys(Dnp) amide; Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-NH2; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysinamide; L-Lysinamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-; Mca-SEVNLDAEFK(Dnp) amide. Grade: ≥95%. CAS No. 1802078-32-5. Molecular formula: C68H89N15O26. Mole weight: 1532.54. | |
| Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human) | Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human), a fluorogenic (FRET) peptide substrate, is used for the tumor necrosis factor (TNF) converting enzyme (TACE, ADAM-17 endopeptidase). Synonyms: Mca-(endo-1a-Dap(Dnp))-TNF-a (-5 to +6) amide (human); Mca-Pro-Leu-Ala-Gln-Ala-Val-Dap(Dnp)-Arg-Ser-Ser-Ser-Arg-NH2; L-Argininamide, 1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl-; 1-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-prolyl-L-leucyl-L-alanyl-L-glutaminyl-L-alanyl-L-valyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-arginyl-L-seryl-L-seryl-L-seryl-L-argininamide. Grade: ≥95% by HPLC. CAS No. 192723-42-5. Molecular formula: C69H103N23O24. Mole weight: 1638.72. | |
| Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 | Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2, a FRET substrate for cathepsin D and E, is also cleaved by napsin A. Synonyms: MOCAc-GKPILFFRL-{Lys(Dnp)}-{D-Arg}-NH2; Mca-GKPILFFRL-Dpa-r-amide; MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-{Lys(Dnp)}-{D-Arg}-NH2; N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-(2,4-dinitrophenyl)-L-lysyl-D-argininamide; D-Argininamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]glycyl-L-lysyl-L-prolyl-L-isoleucyl-L-leucyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-leucyl-N6-(2,4-dinitrophenyl)-L-lysyl-; Cathepsin D and E FRET Substrate. Grade: ≥90%. CAS No. 839730-93-7. Molecular formula: C85H122N22O19. Mole weight: 1756.01. | |
| Mca-KPLGL-Dap(Dnp)-AR-NH2 | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1[1]. (Ex/Em=325 nm/400 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 720710-69-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4931. | |
| MC-Ala-Ala-PAB | MC-Ala-Ala-PAB is a cleavable ADC linker. Fmoc-Ala-Ala-PAB can be used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1949793-44-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148464. | |
| MCA-Lys-Leu-Lys(Dnp) | MCA-Lys-Leu-Lys(Dnp). Synonyms: N6-(2,4-dinitrophenyl)-N2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)-L-lysyl-L-leucyl-L-lysine. Molecular formula: C36H47N7O12. Mole weight: 769.81. | |
| Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 | Mca-KPLGL-Dpa-AR-NH2 is an N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH2 with a Lys yields a fluorogenic peptide with improved substrate properties. Compared with Mca-PLGL-Dpa-AR-NH2, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate Mca-KPLGL-Dpa-AR-NH2 for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased by 2-9 times and 3 times, respectively, while those for gelatinases and matrilysin remain equally high. Synonyms: L-Argininamide, N2-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-; N2-[2-(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-lysyl-L-prolyl-L-leucylglycyl-L-leucyl-3-[(2,4-dinitrophenyl)amino]-L-alanyl-L-alanyl-L-argininamide; MMPs substrate Fluorogenic. Grade: ≥95%. CAS No. 720710-69-0. Molecular formula: C55H80N16O16. Mole weight: 1221.32. | |
| Mca-PL | Mca-PL is a fluorogenic peptide that can be used in the synthesis of Mca-PLGL-Dpa-AR-NH2, a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-7. Synonyms: Matrix Metalloproteinase-2/Matrix Metalloproteinase-7 Fluorogenic Substrate Control; Mca-Pro-Leu-OH; MMP-2/MMP-7 Fluorogenic Substrate Control; N-[1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl]-L-leucine. Grade: ≥95%. CAS No. 140430-55-3. Molecular formula: C23H28N2O7. Mole weight: 444.48. | |
| Mca-PLAQAV-Dpa-RSSSR-NH2 | Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent substrate peptide that can be used to detect ADAM9, ADAM10, and tumor necrosis factor-α converting enzyme (TACE/ADAM17). Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescence resonance energy transfer-based substrate, and its activity can be determined by changes in fluorescence intensity upon cleavage (Ex = 320 nm; Em = 405 nm)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 192723-42-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3722. | |
| Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 | Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is a highly selective MMP-12 FRET substrate with a kcat/Km value of 1.85·105 M-1s-1. It is a poor substrate of other MMPs with the exception of MMP-13 (kcat/Km = 0.53·105 M-1s-1) and MMP-9 (kcat/Km = 0.33·105 M-1s-1). Synonyms: L-Alaninamide, 1-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucylglycyl-L-leucyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-3-[(2,4-dinitrophenyl)amino]-; 1-[(7-Methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-prolyl-L-leucylglycyl-L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-3-[(2,4-dinitrophenyl)amino]-L-alaninamide. Grade: 95%. CAS No. 891198-38-2. Molecular formula: C53H70N12O20. Mole weight: 1195.19. | |
| Mca-Pro-Leu-OH | Mca-Pro-Leu is a fluorescently labeled dipeptide[1]. Uses: Scientific research. Category: Peptides. Alternative Names: Mca-Pro-Leu. CAS No. 140430-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P4645. | |
| m-Carborane | m-Carborane. Group: Biochemicals. Alternative Names: 1, 7-Dicarbadodecaborane (12). Grades: Highly Purified. CAS No. 16986-24-6. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C2H12B10. US Biological Life Sciences. | Worldwide |
| m-Carborane | m-Carborane. Alternative Names: 1,7-DICARBADODECARBORANE(12);M-CARBORANE;1,7-Dicarba-closo-dodecaboran;1,7-Dicarba-closo-dodecaborane(12);1,7-Dicarbadodecaboran;1,7-Dicarbadodecaboran(12);1,7-Dicarbadodecaborane;1,7-dicarbadodecaborane(12). CAS No. 16986-24-6. Molecular formula: C2H2B10. Mole weight: 134.2g/mol. Purity: N/A. SMILES: [B]1[B][B][B][B]C2[B]C([B]2)[B][B][B]1. InChI: InChI=1S/C2H2B10/c3-1-4-2(3)6-8-10-12-11-9-7-5-1/h1-2H. |  |
| m-Carborane-1-carboxylic Acid | m-Carborane-1-carboxylic Acid is used as a reactant or reagent in the synthetic preparation of ortho-carbaborane indomethacin pharmacophores as selective COX-2 enzyme inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 18581-81-2. Pack Sizes: 15mg, 30mg. Molecular Formula: C3H12B10O2, Molecular Weight: 188.24. US Biological Life Sciences. | Worldwide |
| m-Carboxybenzaldehyde | White powder, keep cold, 98%. Synonym: 3-Formylbenzoic Acid. CAS No. 619-21-6. Pack Sizes: Typically in stock: 25g, 100g. Mole weight: 150.13. MP/BP: M.P. 173-175. Order No: FR-2055. |  Frinton Laboratories |
| m-Carboxycinnamic Acid Bishydroxamide | Histone deacetylase inhibitor II. A cell-permeable second generation hybrid polar agent that inhibits HDAC activity. Inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Induces apoptosis and Fas/Fas ligand expression in human neuroblastoma. Group: Biochemicals. Alternative Names: N-Hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]benzamide; CBHA. Grades: Highly Purified. CAS No. 174664-65-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Mca-SEVNLDAEFK(Dnp)-NH2 | Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802078-32-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4920. | |
| MCA-SEVNLDAEFR-K(Dnp)-RR, amide | It is a FRET-based substrate. Synonyms: Mca-(Asn670, Leu671)-APP770(667-676)-Lys(Dnp)-Arg-Arg amide; MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2; Mca-(Asn670, Leu671)-Amyloid beta/A4 Protein Precursor770(667-676)-Lys(Dnp)-Arg-Arg amide. Grade: ≥95%. CAS No. 438625-61-7. Molecular formula: C86H125N27O29. Mole weight: 2001.08. | |
| Mca-YVADAP-Lys(Dnp)-OH | Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2). It is cleaved by caspase-1 or ACE2 to release the fluorescent moiety 7-methoxycoumarin-4-acetyl (Mca), which can be used to quantify enzyme activity. Synonyms: Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH; Caspase-1 Fluorogenic Substrate V; N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-tyrosyl-L-valyl-L-alanyl-L-α-aspartyl-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-L-lysine; L-Lysine, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-tyrosyl-L-valyl-L-alanyl-L-alpha-aspartyl-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-. Grade: ≥95%. CAS No. 189696-01-3. Molecular formula: C53H64N10O19. Mole weight: 1145.15. | |
| MCB-36 | MCB-36 is a VHL-recruiting pan-KRAS PROTAC degrader without affecting KRAS transcription. MCB-36 exhibits minimal effects on HRAS and NRAS protein levels. MCB-36 binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities Kd ? 1 pM). MCB-36 decreases p-ERK levels, leading to cell apoptosis. MCB-36 effectively suppress KRASG12C inhibitor-resistant cancer cells and remodel the tumor immune microenvironment. MCB-36 can be used for the study of colorectal cancer and lung cancer (Pink: Target protein ligand; Blue: E3 ligand (HY-112078); Black: Linker (HY-W091879))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3104382-00-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176786. | |
| MCB-613 | MCB-613 is a potent Steroid receptor coactivator SRC small molecule stimulator (SMS), super-stimulates SRCs transcriptional activity.MCB-613 increases SRCs interactions with other coactivators and markedly induces ER stress coupled to the generation of reactive oxygen species (ROS).MCB-613 is a SMS that target oncogenes can be exploited as anti-cancer agents by over-stimulating the SRC oncogenic program[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1162656-22-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19625. | |
| MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 | MC-(β-Ala)-PABC-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 (Compound Ie) is a neodegrader conjugate, can be used in the synthesis of antibody neoDegrader conjugate (AnDC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2722697-86-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-160497. | |
| MC-betaglucuronide-MMAE-1 | MC-betaglucuronide-MMAE-1 is a agent-linker conjugate for ADC with potent antitumor activity by using MMAE (a tubulin polymerization inhibitor), linked via the cleavable ADC linker MC-betaglucuronide. Uses: Scientific research. Category: Signaling pathways. CAS No. 1703778-92-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136317. | |
| m-CBP | Phosphorescent host material and TADF emitter in OLEDs. Alternative Names: 3,3'-Di(9H-carbazol-9-yl)-1,1'-biphenyl. CAS No. 342638-54-4. Molecular formula: C36H24N2. Mole weight: 484.59. IUPAC Name: 9-[3-(3-carbazol-9-ylphenyl)phenyl]carbazole. SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3N2C4=CC=CC(=C4)C5=CC(=CC=C5)N6C7=CC=CC=C7C8=CC=CC=C86. InChI: InChI=1S/C36H24N2/c1-5-19-33-29(15-1)30-16-2-6-20-34(30)37(33)27-13-9-11-25(23-27)26-12-10-14-28(24-26)38-35-21-7-3-17-31(35)32-18-4-8-22-36(32)38/h1-24H. | |
| MCC950 | MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. Group: Inhibitors. Alternative Names: CP-456773, CRID3. CAS No. 210826-40-7. Pack Sizes: 5mg. Product ID: S8930. Formula: C20H24N2O5S. Smiles: CC(C)(C1=COC(=C1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4)O. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| MCC950 | MCC950 Inhibitor. Uses: Scientific use. Product Category: T6887. CAS No. 256373-96-3. |  |
| MCC950 | MCC950 (CP-456773; CRID3) is a potent and selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-456773; CRID3. CAS No. 210826-40-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12815. | |
| MCC950 sodium | MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-456773 sodium; CRID3 sodium salt. CAS No. 256373-96-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12815A. | |
| MCC950 Sodium | MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes. Group: Inhibitors. Alternative Names: CP-456773 Sodium, CRID3 Sodium. CAS No. 256373-96-3. Pack Sizes: 10mg. Product ID: S7809. Formula: C20H23N2O5S.Na. Smiles: CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MCC-AAQ-Exa | MCC-AAQ-Exa is a drug-linker conjugates for ADC, obtained by condensing the linker with Exatecan (HY-13631) and can be used to prepare antibody-drug conjugates (ADCs). MCC is an ADC linker containing a maleimide fragment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052836-65-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174279. | |
| MCdef | MCdef is a defensin-like peptide detected in hemocytes of Manila clams (Ruditapes philippinarum). MCdef showed highest activity against Streptococcus iniae and Staphylococcus aureus. | |
| Mc-Dexamethasone | Mc-Dexamethasone is a drug-linker conjugate for ADC. Mc-Dexamethasone is made toxin Dexamethasoneconjugated to the non-cleavable MC linker. Dexamethasone is a glucocorticoid receptor agonist. Category: Active pharmaceutical ingredients. CAS No. 1618096-56-2. Product ID: API1618096562. Molecular formula: C29H38FN3O6. Mole weight: 543.636. |  |
| MC-DM1 | MC-DM1 is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody agent conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375089-56-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136286. | |
| MCD Peptide | 22-amino acid peptide with a strongly basic character and 2 disulfide bridges, , from Apis mellifera bee venom, a blocker of voltage-sensitive K+ channels with potent convulsant activity. Synonyms: Peptide 401; Mast Cell Degranulating (MCD) Peptide; Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19); L-isoleucyl-L-lysyl-L-cysteinyl-L-asparagyl-L-cysteinyl-L-lysyl-L-arginyl-L-histidyl-L-valyl-L-isoleucyl-L-lysyl-L-prolyl-L-histidyl-L-isoleucyl-L-cysteinyl-L-arginyl-L-lysyl-L-isoleucyl-L-cysteinyl-glycyl-L-lysyl-L-asparaginamide (3->15),(5->19)-bis(disulfide). Grade: ≥95%. CAS No. 32908-73-9. Molecular formula: C110H192N40O24S4. Mole weight: 2587.22. | |
| Mc-d-Val-d-Cit-PAB-PNP | Mc-d-Val-d-Cit-PAB-PNP is a cleavable ADC linker that can be used for synthesizing antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1350456-68-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173161. | |
| MC-EVCit-PAB-MMAE | MC-EVCit-PAB-MMAE (Linker-Payload 11) is a drug-linker conjugates for ADC. MC-EVCit-PAB-MMAE contains the ADCs linker (MC-EVCit-PAB) and a potent tubulin polymerization inhibitor MMAE (HY-15162)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2873452-49-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-154915. | |
| MCF-7 Transfection Reagent | Transfection Reagent for MCF7 Breast Cancer Cells. Optimized transfection protocol provided for transfection of siRNA, DNA, mRNA, and microRNA. Transfection Reagents. Transfection Enhancer. Complex Condenser. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 1766. |  Nevada, Texas, USA |
| MC-GGFG-AM-(10Me-11F-Camptothecin) | MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2873460-70-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153360. | |
| MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 | MC-GGFG-AM-(10Me-11F-Camptothecin) intermediate-1 (compound 19-2) is an intermediate for the synthesis of MC-GGFG-AM-(10Me-11F-Camptothecin) (HY-153360). Modifying groups can be added group. MC-GGFG-AM-(10Me-11F-Camptothecin) is a drug-linker conjugate used in the synthesis of ADCs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-(2-Amino-4-fluoro-5-methylphenyl)-2-chloroethanone. CAS No. 1241391-14-9. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-400770. | |
| MC-GGFG-Exatecan | MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MC-GGFG-DX8951. CAS No. 1600418-29-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114233. | |
| MC-GGFG-PAB-Exatecan | MC-GGFG-PAB-Exatecan (Compound 94) is a drug-linker conjugate for ADC, and can be used for synthesis of ADCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2928560-25-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160967. | |
| MC-Gly-Gly-Phe | MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC). Uses: Scientific research. Category: Signaling pathways. CAS No. 1599440-15-9. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-44235. | |
| MC-Gly-Gly-Phe-Gly | MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs). Synonyms: (S)-5-Benzyl-18-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecan-1-oic acid. Grade: >98.0%. CAS No. 2413428-36-9. Molecular formula: C25H31N5O8. Mole weight: 529.54. | |
| MC-Gly-Gly-Phe-Gly | MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mc-GGFG-OH. CAS No. 2413428-36-9. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-44246. | |
| MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH | MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Synonyms: Glycinamide,N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[(carboxymethoxy) methyl]-. Grade: >98.0%. CAS No. 1599440-25-1. Molecular formula: C28H36N6O10. Mole weight: 616.62. | |
| MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH | MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1599440-25-1. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-131990. | |
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