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| Product | Description | |
|---|---|---|
| MRT68921 | MRT68921 is a potent NUAK1/ULK1 dual inhibitor. MRT68921 inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 can be used for the research of cancer, such as breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1190379-70-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100006. |  |
| MRT68921 dihydrochloride | MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2080306-21-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100006A. | |
| MRT68921 Hydrochloride | MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. Group: Inhibitors. CAS No. 2070014-87-6. Pack Sizes: 5mg. Product ID: S7949. Formula: C25H34N6O·xHCl. Smiles: CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| MRTX0902 | MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM. Category: Active pharmaceutical ingredients. CAS No. 2654743-22-1. Product ID: API2654743221. Molecular formula: C22H24N6O. Mole weight: 388.47. Appearance: Powder. |  |
| MRTX0902 | MRTX0902 is a potent, selective, brain-penetrant, and orally active SOS1 inhibitor with a Ki of 1.9 nM. MRTX0902 disrupts the SOS1:KRASG12C protein-protein interaction (PPI). MRTX0902 can be used in research on pancreatic ductal adenocarcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2654743-22-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145926. | |
| MRTX1133 | MRTX1133 is a highly selective inhibitor of mutant KRAS G12D and can reversibly binds to the activated and inactivated KRAS G12D mutants and inhibit their activity. The specificity of MRTX1133 to KRAS G12D is more than 1000 times that of wild-type KRAS. Group: Inhibitors. CAS No. 2621928-55-8. Pack Sizes: 5mg. Product ID: E1051. Formula: C33H31F3N6O2. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| MRTX1133 | MRTX1133 is a potent, selective and noncovalent inhibitor of KRASG12D, a promising target for the treatment of solid tumors. Alternative Names: MRTX-1133; MRTX 1133; 4-[4-(3,8-Diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-naphthalenol. Grades: 98%. CAS No. 2621928-55-8. Molecular formula: C33H31F3N6O2. Mole weight: 600.63. |  |
| MRTX1133 | MRTX1133 Inhibitor. Uses: Scientific use. Product Category: T9303. CAS No. 2621928-55-8. |  |
| MRTX1133 | MRTX1133 is a noncovalent, potent, and selective alkyne-based KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated KD against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2621928-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134813. | |
| MRTX-1719 | MRTX1719 is a potent and selective inhibitor of the PRMT5/MTA complex. Alternative Names: MRTX1719; AY4A8WD6JS; (2R)-2-(4-(4-(Aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl)-1-methyl-1H-pyrazol-5-yl)-4-chloro-6-cyclopropoxy-3-fluorobenzonitrile. Grades: 98%. CAS No. 2630904-45-7. Molecular formula: C23H18ClFN6O2. Mole weight: 464.88. | |
| MRTX849 | MRTX849 is a potent and mutation-selective covalent inhibitor of KRAS G12C. It maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. Uses: Antineoplastic agents. Alternative Names: MRTX-849; MRTX 849; Adagrasib; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile. CAS No. 2326521-71-3. Molecular formula: C32H35ClFN7O2. Mole weight: 604.12. | |
| MRTX849 | MRTX849 Inhibitor. Uses: Scientific use. Product Category: T8369. CAS No. 2326521-71-3. | |
| MRTX849 analog 24 | MRTX849 analog 24 is an alkyne-containing click probe analogue of KRAS G12C inhibitor MRTX849, which is used to research MRTX849 function[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2490716-96-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134654. | |
| MRTX9768 | MRTX9768 is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2629314-68-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138684. | |
| MRX-1024 | MRX-1024 is a proprietary oral formulation of D-methionine with antioxidant and antimucositis activities. D-methionine formulation MRX-1024 may selectively protect the oral mucosa from the toxic effects of chemotherapy and radiation therapy without compromising antitumor activity. D-methionine may be converted into the L- isomer in vivo, particlualry in instances of L-methionine deprivation, both isomers have antioxidant activity which may be due, in part, to their sulfur moieties and chelating properties. L-methionine, an essential amino acid, also may help to maintain the ratio of reduced glutathione to oxidized glutathione in cells undergoing oxidative stress and may provide a source of L-cysteine for glutathione synthesis. Alternative Names: Methionine; D-Methionine; (R)-Methionine; NSC 45689; S-Methyl-D-homocysteine; H-D-Met-OH; (R)-2-amino-4-(methylthio)butanoic acid; D-2-Amino-4-(methylthio)butyric acid. Grades: ≥97%. CAS No. 348-67-4. Molecular formula: C5H11NO2S. Mole weight: 149.21. | |
| MRX-2843 | MRX-2843 (UNC2371) is an orally active, ATP-competitive dual MERTK and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC50s of 1.3 nM for MERTK and 0.64 nM for FLT3, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UNC2371. CAS No. 1429882-07-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101549. | |
| MS0124 | MS0124 is a potent selective G9a-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM for GLP and G9a,respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197196-63-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120444. | |
| MS023 | MS023 is a Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. MS023 displayed high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but was completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. Alternative Names: MS023; MS-023; MS 023. Grades: 98%. CAS No. 1831110-54-3. Molecular formula: C17H25N3O. Mole weight: 287.41. | |
| MS023 | MS023, a chemical probe, is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1831110-54-3. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19615. | |
| MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1992047-64-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19615B. | |
| MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective and cell-active human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. Alternative Names: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride; N-{[4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl]methyl}-N-methyl-1,2-ethanediamine dihydrochloride; 1,2-Ethanediamine, N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-, hydrochloride (1:2). Grades: ≥95%. CAS No. 1992047-64-9. Molecular formula: C17H27Cl2N3O. Mole weight: 360.32. | |
| MS-1020 | Selective JAK3 inhibitor. Blocks STAT signaling. Inducer of apoptosis via down-regulation of anti-apoptotic gene expression. Group: Biochemicals. Alternative Names: 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphthamide. Grades: Highly Purified. CAS No. 1255516-86-9. Pack Sizes: 1mg. Molecular Formula: C21H18N2O3. US Biological Life Sciences. |  Worldwide |
| MS10-H500-Pro LCD Digital Magnetic Hotplate Stirrer With 10 Inch Ceramic Plate | Large volume: Up to 30L of liquid on 10-inch hot plate with powerful magnetic stirring. Glass ceramic work plate provides excellent chemical resistant performance and most efficient heat transfer. LCD display for precise monitoring of speed and temperature. External temperature control is possible by connecting the temperature sensor (PT1000) with an accuracy. at ±0.2°C. Digital speed control of 100 -1500rpm. Max. heating plate temperature 500°C. The HOT warning will flash when the work plate temperature is above 50°C even when the hotplate is turned off. Data connector : The SD card also records the instrument's running data in real time. Timing function: the running time of the instrument can be set. Uses: Equipment for sample preparation. Group: Laboratory equipment. Product ID: 8030132117. Categories: Magnetic Hotplate Stirrer. |  |
| MS152 | MS152 is an oral bioactive inhibitor of EHMT2/G9a. MS152 reactivats maternally silenced Prader-Willi syndrome (PWS) genes in brain and liver tissues of PWS mouse models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3107476-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161759. | |
| MS15203 | MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MS0015203. CAS No. 73912-52-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116797. | |
| MS154 | MS154 is a first-in-class E3 ligase cereblon-recruited EGFR degrader with Kd values of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutant, respectively. MS154 potently induces degradation of mutant, but not wild-type, EGFR in cancer cell lines in an E3 ligase-dependent manner. MS154 exhibits anticancer effects against lung cancer (blue: E3 ligase ligand (HY-103596); black: linker (HY-W096167); pink: EGFR ligand (HY-168305))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2550393-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-141640. | |
| MS154N | MS154N (compound 28) is the negative control of MS39 (HY-157581). MS154N is composed of PROTAC target protein ligand EGFR ligand-11 (HY-168305) (red part), E3 ligase ligand 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (HY-W441376) (blue part) and PROTAC Linker 8-Iodooctan-1-amine (HY-168306) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Me-Thalidomide-O-C8-NH2 (HY-168307)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2675490-97-6. Pack Sizes: 1 mg. Product ID: HY-157579. | |
| MS170 | MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376136-61-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-145282. | |
| MS177 | MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2-PRC2 and noncanonical EZH2-cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2225938-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148333. | |
| MS181 | MS181 (compound 1) is a potent cereblon (CRBN)-recruiting and EED-binding polycomb repressive complex 1 (PRC1) PROTAC degrader. MS181 decreases the expression of EED, EZH2, SUZ12, BMI1 and RING1B. MS181 shows antiproliferative activity (Strtucture Note: Red, EED binder (HY-158771); Blue, CRBN ligand (HY-41547); Black, Linker HY-131717)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3037165-65-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158239. | |
| MS1943 | MS1943 is an orally active selective HyT degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency (IC50=120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. (Structure Note: RED, EZH2 ligand (HY-148458); Blue, Hyt (HY-W001578))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2225938-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-133129. | |
| MS21 | MS21 is an effective AKT PROTAC degrader. MS21 can inhibit mutations in the PI3K/PTEN pathway, suppress the proliferation and induce cell cycle arrest of tumor cells. MS21 has anti-tumor activity. (Pink: AKT ligand-2 (HY-48682); Black: Linker (HY-W014125); Blue: (S,R,S)-AHPC (HY-125845))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376137-05-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141807. | |
| MS21570 | MS21570 is a selective GPR171 antagonist, with an IC50 of 220 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 65373-29-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112620. | |
| MS 245 oxalate | MS 245 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 275363-58-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MS-275 | HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 209783-80-2. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C21H20N4O3. US Biological Life Sciences. | Worldwide |
| MS-275 (Entinostat, SNDX-275) | Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8uM). Has no inhibitory activity towards HDAC8 (IC50>100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 209783-80-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MS-282a | MS-282a is produced by the strain of Streptomyces tauricus. It inhibits calmodulin-dependent MLCK with an IC50 of 3.8 μmol/L. It has anti-gram-positive bacteria activity. Alternative Names: MS-282-A. CAS No. 152158-04-8. Molecular formula: C37H65NO7. Mole weight: 635.91. | |
| MS-282b | MS-282b is produced by the strain of Streptomyces tauricus. It inhibits calmodulin-dependent MLCK with an IC50 of 5.2 μmol/L. It has anti-gram-positive bacteria activity. Alternative Names: MS-282-B. CAS No. 152759-50-7. Molecular formula: C37H65NO7. Mole weight: 635.91. | |
| MS33 | MS33 is a potent WDR5 degrader for the study of acute myeloid leukemia, with Kds of 870 and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation through the E3 ligase VHL in a proteasome-dependent manner. Alternative Names: Protac MS33; N1-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)-N11-(2-(4-((4'-(4-methylpiperazin-1-yl)-3'-(6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamido)-[1,1'-biphenyl]-3-yl)methyl)piperazin-1-yl)ethyl)undecanediamide. CAS No. 2407449-11-8. Molecular formula: C64H84F3N11O7S. Mole weight: 1208.48. | |
| MS39 | MS39 (compound 6) is a PROTAC targeting EGFR. MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2675490-92-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157581. | |
| MS402 | MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1672684-68-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120000. | |
| MS4077 | MS4077 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=3 nM); induces ALK protein degradation via cereblon and proteasome dependent mechanism, potently inhibits proliferation of SU-DHL-1?cells with IC50 of 46 nM. Alternative Names: MS4077; MS 4077; MS-4077; 2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]-N-[2-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]acetamide. CAS No. 2230077-10-6. Molecular formula: C55H72ClN9O13S. Mole weight: 1134.73. | |
| MS4077 | MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 37 nM for binding affinity to ALK[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230077-10-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-112156. | |
| MS4078 | MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19?nM for binding affinity to ALK[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2229036-62-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112155. | |
| MS4078 | MS4078 is a novel PROTAC (degrader) of ALK, potently decreases cellular levels of oncogenic active ALK fusion proteins in a concentration- and time-dependent manner in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells (DC50=11 nM); induces ALK protein degradation via cereblon and proteasome dependent mechanism, potently inhibits proliferation of SU-DHL-1?cells with IC50 of 33 nM. Alternative Names: MS-4078; MS4078; MS 4078; 2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]-N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]acetamide. CAS No. 2229036-62-6. Molecular formula: C45H52ClN9O8S. Mole weight: 914.47. | |
| MS41 | MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC50s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094). Black: linker (HY-W105744). Blue: VHL ligand (HY-112078)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768610-97-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-169093. | |
| MS417 | MS417 is a selective BET-specific BRD4 inhibitor, binds to BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively, with weak selectivity at CBP BRD (IC50, 32.7 μM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: GTPL7512. CAS No. 916489-36-6. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111139. | |
| MS432 | MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2672512-44-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130602. | |
| MS4322 | MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 ))[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YS43-22. CAS No. 2375432-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-141877. | |
| MS436 | MS436 is a new class of bromodomain inhibitor, exhibits potent affinity of an estimated Ki=30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1395084-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13959. | |
| MS436 | MS436 is a BRD4 bromodomain inhibitor, which exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Alternative Names: MS-436; MS 436. Grades: >98%. CAS No. 1395084-25-9. Molecular formula: C18H17N5O3S. Mole weight: 383.42. | |
| MS437 | MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10-8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 541535-31-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114994. | |
| MS438 | MS438 is a potent thyrotropin receptor (TSHR) agonist with an EC50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 512840-45-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-114918. | |
| MS-444 | MS-444, originally isolated from Micromonospora sp. KY7123, is a myosin light chain kinase (MLCK) inhibitor. Alternative Names: 5,8-Dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone; MS 444; 5,8-dihydroxy-3-methyl-9H-benzo[f][2]benzofuran-4-one. CAS No. 150045-18-4. Molecular formula: C13H10O4. Mole weight: 230.22. | |
| MS-444 | MS-444 (BE-34776) is a HuR (ELAVL1) inhibitor that blocks the cytoplasmic translocation of HuR and inhibits its dimerization. MS-444 reduces cytoplasmic HuR levels by preventing the binding of HuR to ARE-mRNA, without altering the total expression of HuR. MS-444 induces apoptosis, inhibits cell growth, angiogenesis and invasion, and also regulates immune function and microbiota. MS-444 effectively alters the number, size and invasiveness of tumors in various cancer models. MS-444 is tolerable to intraperitoneal injection in vivo and can be applied to research related to colorectal cancer, familial adenomatous polyposis, colitis-associated cancer and glioblastoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BE-34776. CAS No. 150045-18-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100685. | |
| MS48107 | MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375070-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134494. | |
| MS-553 | MS-553 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1046787-18-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16903. | |
| MS6105 | MS6105 is an LDH protein hydrolysis-targeted chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner and has anticancer activity[1]. MS6105 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2891709-58-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-152261. | |
| MS67 | MS67 is a potent and selective degrader of WD40 repeat domain protein 5 (WDR5) (Kd = 63 nM) with potent anticancer effects. MS67 has no activity against other protein methyltransferases, kinases, GPCRs, ion channels and transporters. Alternative Names: N-(2'-fluoro-5'-((2-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethyl)carbamoyl)-4-((3R,5S)-3,4,5-trimethylpiperazin-1-yl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide. Grades: ≥95%. CAS No. 2407452-77-9. Molecular formula: C52H59F4N9O7S. Mole weight: 1030.14. | |
| MS67 | MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2407452-77-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141796. | |
| MS-681a | MS-681a, originally isolated from Myrothecium sp. KY6568, is a myosin light chain kinase (MLCK) inhibitor (IC50=0.11 μmol/L). CAS No. 173485-72-8. Molecular formula: C61H91N13O9. Mole weight: 1150.45. | |
| MS7710 | MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits HCN channel-mediated Ih current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3095336-10-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172550. | |
| MS7-H550-Pro LCD Digital Magnetic Hotplate Stirrer With 7 Inch Ceramic Plate | LCD displays actual temperature & speed. Built-in PID controller ensures safe heating of the medium with overheating protection. Maximum heating plate temperature up to 550°C. Glass ceramic work plate is resistant to corrosion and is easy to clean. External temperature control is possible by connecting temperature sensor(PT1000) with an accuracy of ±0. 2°C. Digital speed control with maximum range of 1500rpm. Outstanding brushless DC motor offers more stirring power. Two knobs enable easy adjustment of speed and temperature. HOT warning flashes when work plate temperature is above 50°C even when hotplate is turned off. Remote function provides PC control and data transmission. Uses: Equipment for sample preparation. Group: Laboratory equipment. Product ID: 8030122111. Categories: Magnetic Hotplate Stirrer. | |
| MS7-H550-S LED Magnetic Hotplate Stirrer With 7 Inch Ceramic Plate | LED displays actual temperature. Built-in PID controller ensures safe heating of the medium with overheating protection. Maximum heating plate temperature up to 550°C. Glass ceramic work plate is resistant to corrosion and is easy to clean. External temperature control is possible by connecting temperature sensor(PT1000) with an accuracy of ±0. 2°C. Digital speed control with maximum range of 1500rpm. Outstanding brushless DC motor offers more stirring power. Two knobs enable easy adjustment of speed and temperature. HOT warning flashes when work plate temperature is above 50°C even when hotplate is turned off. Remote function provides PC control and data transmission. Uses: Equipment for sample preparation. Group: Laboratory equipment. Product ID: 8030122211. Categories: Magnetic Hotplate Stirrer. | |
| MS8709 | MS8709 (compound 10), a potential anticancer therapeutic, is a first-in-class G9a/GLP PROTAC degrader. MS8709 is based on G9a/GLP inhibitor UNC0642 and recruits the von Hippel Lindau (VHL) E3 ligase (Red: G9a/GLP inhibitor UNC0642; Blue: VHL ligand; Black: linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3060730-06-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-162362. | |
| MS8815 | MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2855085-25-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148334. | |
| MS8847 | MS8847 is a PROTAC degrader and antiproliferative agent targeting EZH2 (DC50=34.4 nM in EOL-1 MLL-rAML cells). MS8847 recruits the E3 ligase von Hippel-Lindau (VHL) to mediate the degradation of EZH2 via the ubiquitin-proteasome system. MS8847 induces antiproliferative effects in MLL-rearranged acute myeloid leukemia cells and inhibits the growth of triple-negative breast cancer cell lines or 3D triple-negative breast cancer models. MS8847 is applicable to research related to MLL-rearranged acute myeloid leukemia and triple-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3050872-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-162250. | |
| MS934 | MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader. MS934 also degrades CRAF. MS934 can be used for the research of variety of human cancers, such as melanoma, nonsmall cell lung cancer (NSCLC), colorectal cancer, primary brain tumors, and hepatocellular carcinoma (Pink: Target protein ligand (HY-168288); Black: linker (HY-168289); Blue: E3 ligase ligand (HY-112078))[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2756323-15-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153863. | |
| MSA-2 | MSA-2 is a STING agonist that exhibits antitumor effects in animal studies. Alternative Names: MSA 2; MSA2; 4-(5,6-dimethoxybenzo[b]thiophen-2-yl)-4-oxobutanoic acid. Grades: 98% by HPLC. CAS No. 129425-81-6. Molecular formula: C14H14O5S. Mole weight: 294.32. | |
| MSA-2 | MSA-2 Inhibitor. Uses: Scientific use. Product Category: T8798. CAS No. 129425-81-6. | |
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