A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(piperazin-1-yl)propoxy)quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S,R,S)-AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2675490-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157581.
MS4078
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19?nM for binding affinity to ALK[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2229036-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112155.
MS41
MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC 50 s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094). Black: linker (HY-W105744). Blue: VHL ligand (HY-112078) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768610-97-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-169093.
MS432
MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2672512-44-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130602.
MS4322
MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 ?M in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 ))[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YS43-22. CAS No. 2375432-47-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-141877.
MS438
MS438 is a potent thyrotropin receptor ( TSHR ) agonist with an EC 50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 512840-45-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-114918.
MS-444
MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 ?M. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BE-34776. CAS No. 150045-18-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100685.
MS-444
MS-444, originally isolated from Micromonospora sp. KY7123, is a myosin light chain kinase (MLCK) inhibitor. Synonyms: 5,8-Dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone; MS 444; 5,8-dihydroxy-3-methyl-9H-benzo[f][2]benzofuran-4-one. CAS No. 150045-18-4. Molecular formula: C13H10O4. Mole weight: 230.22.
MS67
MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2407452-77-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141796.
MS-681a
MS-681a, originally isolated from Myrothecium sp. KY6568, is a myosin light chain kinase (MLCK) inhibitor (IC50=0.11 μmol/L). CAS No. 173485-72-8. Molecular formula: C61H91N13O9. Mole weight: 1150.45.
MS8709
MS8709 (compound 10), a potential anticancer therapeutic, is a first-in-class G9a/GLP PROTAC degrader. MS8709 is based on G9a/GLP inhibitor UNC0642 and recruits the von Hippel Lindau (VHL) E3 ligase (Red: G9a/GLP inhibitor UNC0642; Blue: VHL ligand; Black: linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3060730-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-162362.
MS934
MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader. MS934 also degrades CRAF. MS934 can be used for the research of variety of human cancers, such as melanoma, nonsmall cell lung cancer (NSCLC), colorectal cancer, primary brain tumors, and hepatocellular carcinoma (Pink: Target protein ligand (HY-168288); Black: linker (HY-168289); Blue: E3 ligase ligand (HY-112078))[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756323-15-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153863.
MSA-2
MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 ?M for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-? secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129425-81-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-136927.
MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 173436-66-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120697.
m-Salicylic Acid
m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780). Group: Biochemicals. Alternative Names: 3-Hydroxybenzoic Acid; 3-Carboxyphenol; NSC 55746; m-Carboxyphenol; m-Hydroxybenzoic Acid. Grades: Highly Purified. CAS No. 99-06-9. Pack Sizes: 10g. US Biological Life Sciences.
Worldwide
MSBN
MSBN is a highly selective fluorogenic probe for thiols. MSBN can be used to image thiols in live cells selectively and specifically label protein thiols with a signal to determine various reversible protein thiol modifications [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 135980-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119493.
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC50 values of 0.71 ?M and 7.2 ?M for VPS4B and p97, respectively[1]. MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2219320-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123872.
MSC2530818
MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883423-59-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101611.
MSC-4381
MSC-4381 (MCT4-IN-1) is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC 50 of 77 nM and a K i of 11 nM. MSC-4381 targets to the cytosolic domain of MCT4. MSC-4381 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MSC-4381 has the potential for MCT4 transporter inhibition research [1]. MSC-4381 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MCT4-IN-1. CAS No. 2445185-57-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132301.
MSD-819 is extracted from Streptomycess ambofaciens. It has anti-gram-positive and anti-gram-negative bacteria activity. Synonyms: 2-Quinoxalinecarboxylicacid, 6-chloro-, 1,4-dioxide; 3-Carboxy-7-chloro-1-oxoquinoxalin-1-ium-4(1H)-olate. CAS No. 22587-15-1. Molecular formula: C9H5ClN2O4. Mole weight: 240.60.
MSD-92
It is originally isolated from Actinomyces sp. MSD-92 has anti-gram-positive and anti-gram-negative activity, and the MIC of it against Escherichia coli was 2 μg/mL. Synonyms: 2-Methylfervenulone; BRN 0540815; 2,8-Dihydro-2,6,8-trimethylpyrimido(5,4-e)-as-triazine-3,5,7-trione. CAS No. 22712-32-9. Molecular formula: C8H9N5O3. Mole weight: 223.19.
MSDC 0160
MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimers disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mitoglitazone; CAY10415. CAS No. 146062-49-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100550.
Msdh-c
Msdh-c. Uses: Designed for use in research and industrial production. Additional or Alternative Names: D-ERYTHRO-1-METHYLTHIOHYDROCERAMIDE;(2R,3R)-(2-N-LAUROYL)-AMINO-1-METHYLTHIO-3-HYDROXYNONAN;MSDH-C. Product Category: Heterocyclic Organic Compound. Appearance: White to off-white powder. CAS No. 144474-37-3. Molecular formula: C22H45NO2S. Mole weight: 387.66. Product ID: ACM144474373. Alfa Chemistry ISO 9001:2015 Certified. Categories: MS Dhoni.
MSG606
MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist and can be used for the research of neuroprotective effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416983-77-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1726.
MSG 606
MSG 606 is a potent human MC1 receptor antagonist (IC50 = 17 nM), and also partial agonist at human MC3 and MC5 receptors (EC50= 59 and 1300 nM, respectively). Synonyms: MSG 606; MSG606; MSG-606. CAS No. 1416983-77-1. Molecular formula: C62H82N20O13S. Mole weight: 1347.51.
MSI-1436
MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B) , with an IC 50 of appr 1 μM, 200-fold preference over TCPTP (IC 50 , 224 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Trodusquemine; Aminosterol-1436. CAS No. 186139-09-3. Pack Sizes: 500 μg. Product ID: HY-12219.
MSI-1436 lactate
MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B ( PTP1B ), with an IC 50 of 1 μM, 200-fold preference over TCPTP ( IC 50 of 224 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Trodusquemine lactate; Aminosterol-1436 lactate. CAS No. 1309370-86-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12219A.
MSI-594
MSI-594 is a highly active AMP with a broad-spectrum of activities against bacteria, fungi, and virus.
mSIRK
mSIRK (G-Protein ?? Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 ?M. mSIRK disrupts the interaction between ? and ?? subunits and promotes ? subunit dissociation without stimulating nucleotide exchange[1]. Uses: Scientific research. Group: Peptides. CAS No. 593267-11-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P5985.
mSiTrz
mSiTrz. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-Phenyl-4,6-bis(3-(triphenylsilyl)phenyl)-1,3,5-triazine. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2252416-90-1. Molecular formula: C57H43N3Si2. Mole weight: 826.14 g/mol. Product ID: ACM2252416901. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mistrzejowice.
Msk-195
Msk-195. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SureCN93984, CTK8E9625, MSK-195, 289902-82-5. Product Category: Heterocyclic Organic Compound. Appearance: White solid. CAS No. 289902-82-5. Molecular formula: C28H40N2O5. Mole weight: 484.6. Purity: 0.96. IUPACName: [2-[[[2-[4-(2-aminoethoxy)-3-methoxyphenyl]acetyl]amino]methyl]-3-(3,4-dimethylphenyl)propyl] 2,2-dimethylpropanoate. Product ID: ACM289902825. Alfa Chemistry ISO 9001:2015 Certified.
MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 ?M. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1592908-16-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120079.
MSN-50
MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1592908-75-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118948.
MSNBA
MSNBA is a specific inhibitor of GLUT5 fructose transport in proteoliposomes. MSNBA competitively inhibits GLUT5 fructose uptake with a K I of 3.2±0.4 μM in MCF7 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 852702-51-3. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W179181.
Msop
Msop. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MSOP;(RS)-ALPHA-METHYLSERINE-O-PHOSPHATE;(R,S)-a-Methylserine-O-phosphate. Product Category: Heterocyclic Organic Compound. CAS No. 66515-29-5. Molecular formula: C4H10NO6P. Mole weight: 199.1. Product ID: ACM66515295. Alfa Chemistry ISO 9001:2015 Certified.
MSOP
MSOP. Group: Biochemicals. Grades: Purified. CAS No. 66515-29-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
MSOP
MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent K D of 51 μM for the L-AP4-sensitive presynaptic mGluR. Uses: Scientific research. Group: Signaling pathways. CAS No. 66515-29-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101226.
MSP-3 is a potent TRPV1 agonist, with an EC 50 of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820968-63-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118785.
MspA1 I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 10-fold overdigestion with enzyme 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 500 U; 2500U. CMG↑CKG GKC↓GMC. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer Y, BSA. Storage: -20°C. Storage at -70°C is recommended for periods longer than 30 days. Form: Liquid. Source: Moraxella species A1. Pack: 20 mM Tris-HCl (pH 7.6); 300 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 10 mM MgCl2, 200 μg/ml BSA, 50% glycerol. Cat No: ET-1140RE.
MSPC
MSPC is an asymmetrical phosphatidylcholine containing a myristic acid (14:0) at the sn-1 position and a stearic acid (18:0) at the sn-2 position. It can self assemble in water to form lipid bilayers. Reagent grade, for research purpose. Uses: Scientific research. Group: Natural products. Alternative Names: PC(14:0/18:0); 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine. CAS No. 76343-22-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W019833.
MS-PEG3-t-butyl ester
MS-PEG3-t-butyl ester. Uses: Designed for use in research and industrial production. Product Category: Other PEG Linkers. CAS No. 1312309-62-8. Molecular formula: C12H24O7S. Mole weight: 312.38. Purity: 95%+. Product ID: ACM1312309628. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mes-PEG2-acid t-butyl ester.
MS-PEG4-MS
MS-PEG4-MS. Uses: Designed for use in research and industrial production. Product Category: Other PEG Linkers. CAS No. 55400-73-2. Molecular formula: C10H22O9S2. Mole weight: 350.41. Purity: 95%+. Product ID: ACM55400732. Alfa Chemistry ISO 9001:2015 Certified.
MS-PEG4-THP
MS-PEG4-THP. Uses: Designed for use in research and industrial production. Product Category: Other PEG Linkers. CAS No. 145927-73-7. Molecular formula: C14H28O8S. Mole weight: 356.43. Purity: 95%+. Product ID: ACM145927737. Alfa Chemistry ISO 9001:2015 Certified.
MSPG
MSPG. Group: Biochemicals. Grades: Purified. CAS No. 169209-64-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Msp I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. C↑CGG GGC↓C. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B. Storage: -20°C. Form: Liquid. Source: Moraxella species. Pack: 10 mM Tris-HCl (pH 7.5); 50 mM KCl; 0,1 mM EDTA; 7 mM 2-mercaptoethanol; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1139RE.
MspR9 I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA (dcm-) in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 2-fold mspr9 i overdigestion >5% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 1000U; 5000U. CC↑NGG GGN↓CC. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer O. Storage: -20°C. Form: Liquid. Source: Micrococcus species R9. Pack: 10 mM Tris-HCl (pH 7.5); 100 mM NaCl; 0,1 mM EDTA; 7 mM 2-mercaptoetyanol; 100 μg/ml BSA; and 50% glycerol. Cat No: ET-1141RE.
Msr-Ratio (Msr-green) is a ratiometric fluorescent probe of methionine sulfoxide reductase (λex=375 nm, λem=550 nm). Msr-Ratio is used for monitoring the enzyme activity in vitro and in live cells [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Msr-green. CAS No. 2290635-22-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D1257.
MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM). Uses: Designed for use in research and industrial production. Additional or Alternative Names: Telomerase Inhibitor IX, MST-312, CHEMBL2170856, N,N-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine, 368449-04-1, CTK1B6051, IN1063, ZINC03937611, AG-F-28784, Benzamide, N,N-1,3-phenylenebis[2,3-dihydroxy-, N,N inverted exclamation marka-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]. Product Category: Inhibitors. Appearance: Solid. CAS No. 368449-04-1. Molecular formula: C20H18N2O6. Mole weight: 382.37. Purity: ≥95%. IUPACName: N-[3-[(2,3-dihydroxybenzoyl)amino]phenyl]-2,3-dihydroxybenzamide. Canonical SMILES: C1=CC(=CC(=C1)NC(=O)C2=C(C(=CC=C2)O)O)NC(=O)C3=C(C(=CC=C3)O)O. Product ID: ACM368449041. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mt. 3:12.
MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Telomerase Inhibitor IX. CAS No. 368449-04-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120145.
MSU38225 is an Nrf-2 inhibitor that increases levels of reactive oxygen species (ROS). MSU38225 inhibits the growth of human lung cancer cells and enhances the sensitivity of human lung cancer cells to chemotherapy in vitro and in vivo. MSU38225 can be used in cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629160-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153873.
MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2060573-82-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111976.
MT-1207
MT-1207 is an orally active and selective adrenergic α 1 and 5-HT 2A receptor antagonist. MT-1207 shows IC 50 <0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α 1A , α 1B , α 1D and 5-HT 2A , respectively. MT-1207 achieves an effective blood pressure (BP) reduction in the 2K2C rat model without damaging renal function. MT-1207 is a potent multitarget inhibitor with the potential for vasodilatation research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1610794-70-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162677.
MT1-MMP Inhibitor, NSC405020
The MT1-MMP Inhibitor, NSC405020 controls the biological activity of MT1-MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy.
A cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-b3/MT tumor growth in xenografted mice (0.5mg/kg, intratumoral). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
MT-4
MT-4 is a derivative of a tissue transglutaminase ( TG2 ) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel. Uses: Scientific research. Group: Signaling pathways. CAS No. 2327925-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128595.