A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
NVP-BSK805, a quinoxaline derivative, is a selective ATP-competitive JAK2 inhibitor which could induce apoptosis (GI50 < 100 nM) and restrain the growth of JAK2V617F cells (Ba/F3). Alternative Names: 4-(2,6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine; BSK 805; 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline. Grades: 98%. CAS No. 1092499-93-8. Molecular formula: C27H28F2N6O. Mole weight: 490.55.
NVP-CGM097
NVP-CGM097 is a potent and selective MDM2 inhibitor with IC50 of 1.7±0.1 nM for hMDM2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGM097. CAS No. 1313363-54-0. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15954.
NVP-DFF332
HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HIF-2α-IN-8. CAS No. 2734922-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148860.
NVP-DFV890
NVP-DFV890 is an orally administered, selective NLRP3 inhibitor. NVP-DFV890 directly binds to NLRP3, blocks maturation of pro-inflammatory cytokines IL-1β and IL-18, and inhibits pyroptotic cell death. NVP-DFV890 acts as an inducer of viral clearance, promoting earlier clearance of SARS-CoV-2. NVP-DFV890 can be used for the research of COVID-19 pneumonia and coronavirus-associated acute respiratory distress syndrome (CARDS)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NLRP3 antagonist 2. CAS No. 2271394-34-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155876.
NVP-DKY709
NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53% and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 (DC50: 13 nM) and SALL4 (DC50: 2 nM). NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2291360-73-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-144998.
NVP DPP 728 dihydrochloride
NVP DPP 728 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 207556-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NVP-HDM201
NVP-HDM201 (HDM201) is a potent and highly specific MDM-2/p53 inhibitor that binds to human Mdm2 protein with a sub-nanomolar Ki value, activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells. Alternative Names: Siremadlin; HDM201; HDM 201; HDM-201; NVP-HDM-201; NVP-HDM 201. CAS No. 1448867-41-1. Molecular formula: C26H24Cl2N6O4. Mole weight: 555.41.
NVP-HSP990
NVP-HSP990 is a potent, selective and orally active Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HSP-990. CAS No. 934343-74-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15190.
NVP-TAE 226
NVP-TAE 226 (TAE226) is a potent and ATP-competitive dual FAK and IGF-1R inhibitor with IC50s of 5.5 nM and 140 nM, respectively. NVP-TAE 226 (TAE226) also effectively inhibits Pyk2 and insulin receptor (InsR) with IC50s of 3.5 nM and 44 nM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAE226. CAS No. 761437-28-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13203.
NVP-TAE 684
NVP-TAE 684 (TAE 684) is a highly potent and selective ALK inhibitor, which blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 values between 2 and 10 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAE 684. CAS No. 761439-42-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10192.
NVP-TNKS656
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TNKS656. CAS No. 1419949-20-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13990.
NVR 3-778
NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) belonging to the SBA (sulfamoylbenzamide) class, with anti-HBV activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1445790-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124600.
NVS-CECR2-1
NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC50=47 nM; KD=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism[1]. NVS-CECR2-1 is a chemical probe. Uses: Scientific research. Category: Signaling pathways. CAS No. 1992047-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110374.
NVS-PAK1-1
NVS-PAK1-1 is potent and specific allosteric PAK1 inhibitor (IC50 = 5 nM) with selective over PAK2 and a panel of 442 kinases. Alternative Names: NVS-PAK1-1; NVSPAK11; NVS PAK1 1; (3S)-3-[[8-chloro-11-(2,2-difluoroethyl)-3-fluorobenzo[b][1,4]benzodiazepin-6-yl]amino]-N-propan-2-ylpyrrolidine-1-carboxamide. CAS No. 1783816-74-9. Molecular formula: C23H25ClF3N5O. Mole weight: 479.93.
NVS-PAK1-1
NVS-PAK1-1, a chemical probe, is a potent and selective allosteric PAK1 inhibitor with an IC50 of 5 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1783816-74-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100519.
NVS-SM2
NVS-SM2 is a potent, orally active and brain-penetrant SMN2 splicing enhancer with an EC50 of 2 nM for SMN. NVS-SM2 enhances U1-pre-mRNA association. NVS-SM2 promotes exon 7 inclusion and restores normal survival motor neuron (SMN) protein expression. NVS-SM2 can be used for spinal muscular atrophy (SMA) research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1562333-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111520.
NVS-STG2
NVS-STG2 is a molecular glue that targets STING
NVS-ZP7-4
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2349367-89-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114395.
Nw-Nitro-D-arginine methyl ester hydrochloride 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 50912-92-0. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Nw-Nitro-L-arginine 99+%
Nw-Nitro-L-arginine 99+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g, 1Kg. US Biological Life Sciences.
Worldwide
Nw-Nitro-L-arginine methyl ester hydrochloride
Nw-Nitro-L-arginine methyl ester hydrochloride. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g, 100g, 250g. US Biological Life Sciences.
Worldwide
Nw,Nw'-Di-Z-L-arginine
Nw,Nw'-Di-Z-L-arginine. Group: Biochemicals. Grades: Reagent Grade. CAS No. 4125-79-5. Pack Sizes: 250mg, 1g, 5g, 25g. US Biological Life Sciences.
Worldwide
Nw-Propyl-L-Arginine
A highly selective competitive inhibitor and inactivator of all three isoforms of NOS. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
NX-1607
NX-1607 (Compound 23) is an inhibitor of Cbl-b, an E3 enzyme in the ubiquitin-proteasome pathway, with an IC50 value of less than 1 nM. NX-1607 can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cbl-b-IN-3. CAS No. 2573775-59-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141432.
NXE0041178
NXE0041178 is an orally active and BBB-penetrant full GPR52 agonist, with a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM (pEC50 = 7.55) for rat GPR52. NXE0041178 shows no significant inhibition on hERG, hNaV1.5 and cytochrome P450 isoforms. NXE0041178 can reduce d-amphetamine-induced hyperactivity in rats. NXE0041178 can be used for research of Neurological disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2642079-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154980.
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCT361814. CAS No. 1693734-80-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145927.
NXPZ-2
NXPZ-2 is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with a Ki value of 95 nM, EC50 value of 120 and 170 nM. NXPZ-2 can dose-dependently ameliorate Aβ[1-42]-Induced cognitive dysfunction, improve brain tissue pathological changes in Alzheimers disease (AD) mouse by increasing neuron quantity and function. NXPZ-2 can inhibit oxidative stress by increasing Nrf2 expression levels and promoting its cytoplasm to nuclear translocation, which is helpful for Keap1-Nrf2 PPI inhibitors and AD associated disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2254492-08-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149010.
NXT629
NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively[1]. NXT629 has potent anti-tumor activity and inhibits experimental metastasis of cancer cell in animal models[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454925-59-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114263.
NXY 059
NXY 059. Group: Biochemicals. Grades: Purified. CAS No. 168021-79-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NYAD-1
NYAD-1 is a cell-penetrating alpha-helical peptide that is used as a potential HIV-1 inhibitor. The hydrocarbon-stapled structure enhances alpha helicity. Alternative Names: H-Ile-Thr-Phe-X-Asp-Leu-Leu-X-Tyr-Tyr-Gly-Pro-NH2. Grades: ≥95%. Mole weight: 1450.70.
Nyasol
Nyasol is purified from the rhizomes of Anemarrhena asphodeloides. Nyasol may have the potential to be developed as a medicine for the treatment of allergies by inhibiting the activation of mast cells. Nyasol has antifungal activity and suppresses the Phytophthora blight on pepper plants. Alternative Names: Cis-Hinokiresinol. Grades: 98.0%. CAS No. 96895-25-9. Molecular formula: C17H16O2. Mole weight: 252.31.
Nybomycin
An unusual heterocyclic metabolite isolated from several streptomyces species; possesses antiviral and antibacterial activity. Alternative Names: NSC613948; 8-(Hydroxymethyl)-6,11-dimethyl-2H,4H-oxazolo[5,4,3-ij]pyrido[3,2-g]quinoline-4,10(11H)-dione; 8,9-Dihydro-4-(hydroxymethyl)-6,9-dimethyl-2,8-dioxopyrido(3,2-g)quinoline-1(2H)-carboxaldehyde. Grades: >95% by HPLC. CAS No. 30408-30-1. Molecular formula: C16H14N2O4. Mole weight: 298.29.
NY-BR-1 p904 A2
It is an HLA-A2-restricted NY-BR-1 epitope. T-cell clone specific for NY-BR-1 p904 can recognize breast tumor cells expressing NY-BR-1. Alternative Names: L-Valine, L-seryl-L-leucyl-L-seryl-L-lysyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-threonyl-; H-Ser-Leu-Ser-Lys-Ile-Leu-Asp-Thr-Val-OH. Grades: ≥95%. CAS No. 347142-73-8. Molecular formula: C43H78N10O15. Mole weight: 975.14.
NY-BR-1 p904 A2 acetate
T-cell clones specific for this NY-BR-1 epitope (p904) can recognize breast tumor cells expressing NY-BR-1. Molecular formula: C45H82N10O17. Mole weight: 1035.20.
NY-CO-13 (139-147)
NY-CO-13(187-197) is amino acids 139 to 147 fragment of NY-CO-13. NY-CO-13 is any isoform of a protein encoded by TP53 gene. TP53 gene is the most frequently mutated gene in human cancer indicating that the TP53 gene plays a crucial role in preventing cancer formation. Alternative Names: Cellular Tumor Antigen p53 (139-147); Tumor Suppressor p53 (139-147); Tp53 (139-147).
NY-CO-13 (187-197)
NY-CO-13 (187-197) is amino acids 187 to 197 fragment of NY-CO-13. NY-CO-13 is any isoform of a protein encoded by TP53 gene. TP53 gene is the most frequently mutated gene in human cancer indicating that the TP53 gene plays a crucial role in preventing cancer formation. Alternative Names: Cellular Tumor Antigen p53 (187-197); Tumor Suppressor p53 (187-197).
A fragment of NY-ESO-1. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Alternative Names: Gly-Ala-Arg-Gly-Pro-Glu-Ser-Arg-Leu-Leu-Glu-Phe-Tyr-Leu-Ala-Met-Pro-Phe-Ala-Thr-Pro-Met-Glu-Ala-Glu-Leu-Ala-Arg-Arg-Ser. Molecular formula: C149H236N42O43S2. Mole weight: 3368.02.
NY-ESO-1 (155-163)
NY-ESO-1 (155-163) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Alternative Names: Cancer / testis antigen 1 (155-163).
NY-ESO-1 (157-165)
NY-ESO-1 (157-165) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Alternative Names: Cancer / testis antigen 1 (157-165).
NY-ESO-1 (157-165) peptide
NY-ESO-1 (157-165) peptide is a peptide fragment from NY-ESO-1 protein. NY-ESO-1 (157-165) peptide can activate the immune system, especially for HLA-A2 positive individuals, it can be recognized by CD8+ T cells, thus triggering an immune response. NY-ESO-1 (157-165) peptide is expressed in a variety of tumors and can be used as a target for tumor immunotherapy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 202815-17-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10493.
NY-ESO-1 (161-180)
NY-ESO-1 (161-180) is a 20-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Alternative Names: Cancer / testis antigen 1 (161-180).
NY-ESO-1 (87-97)
NY-ESO-1 (87-97) is a fragment of the NY-ESO-1. NY-ESO-1 is a cancer-testis antigen (CTA) with re-expression in numerous cancer types. Alternative Names: Leu-Leu-Glu-Phe-Tyr-Leu-Ala-Met-Pro-Phe-Ala. Molecular formula: C66H95N11O15S. Mole weight: 1314.66.
NY-ESO-1 (87-99)
NY-ESO-1 (87-99) is a fragment of the NY-ESO-1. NY-ESO-1 is a cancer-testis antigen (CTA) with re-expression in numerous cancer types. Alternative Names: Leu-Leu-Glu-Phe-Tyr-Leu-Ala-Met-Pro-Phe-Ala-Thr-Pro. Molecular formula: C75H109N13O18S. Mole weight: 1512.89.
NY-ESO-1 (89-97)
NY-ESO-1 (89-97) is a fragment of the NY-ESO-1. NY-ESO-1 is a cancer-testis antigen (CTA) with re-expression in numerous cancer types. Alternative Names: Glu-Phe-Tyr-Leu-Ala-Met-Pro-Phe-Ala. Molecular formula: C54H73N9O13S. Mole weight: 1088.32.
NY-ESO-1 (89-99)
NY-ESO-1 (89-99) is a fragment of the NY-ESO-1. NY-ESO-1 is a cancer-testis antigen (CTA) with re-expression in numerous cancer types. Alternative Names: Glu-Phe-Tyr-Leu-Ala-Met-Pro-Phe-Ala-Thr-Pro. Molecular formula: C63H87N11O16S. Mole weight: 1286.55.
NY-ESO-1 peptide (1-9)
NY-ESO-1 peptide (1-9) is a 9-aa peptide. NY-ESO-1 is an archetypical example of a CTA with restricted expression to germ cells and placental cells and re-expression in tumor cells. It is beneficial to research in the treatment of melanoma. Alternative Names: Cancer / testis antigen 1 (1-9).
Nylon 11 is a polyamide, bioplastic and a member of the nylon family of polymers produced by the polymerization of 11-aminoundecanoic acid. Alternative Names: Polyundecanolactam. CAS No. 25035-04-5. Molecular formula: [-NH(CH2)10CO-]n. Mole weight: 201.31. IUPAC Name: 11-aminoundecanoic acid. SMILES: NCCCCCCCCCCC(O)=O. InChI: InChI=1S/C11H23NO2/c12-10-8-6-4-2-1-3-5-7-9-11(13)14/h1-10,12H2,(H,13,14).
Nylon 12
Nylon 12 is a nylon polymer. It is made from omega-aminolauric acid or laurolactam monomers, each of which has 12 carbon atoms, hence the name "nylon 12". It is one of several nylon polymers. Alternative Names: Polylauryllactam. CAS No. 24937-16-4. Molecular formula: (C12H23NO)n. Mole weight: 591.95. SMILES: O=C1CCCCCCCCCCCN1.
Nylon 12 Granules
Nylon 12 Granules. CAS No. 24937-16-4. Purity: 99.9%.
It is a semi-crystalline polyamide. Unlike most other nylons, nylon 6 is not a condensation polymer, but is formed by ring-opening polymerization; it is made from nylon 6. Alternative Names: Polycaprolactam. CAS No. 25038-54-4. Molecular formula: [-NH(CH2)5CO-]n. InChI: 1S/C6H13NO/c1-2-3-4-5-6(7)8/h2-5H2,1H3,(H2,7,8).