A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
N- (Trimethylsilyl) dimethylamine. Group: Biochemicals. Alternative Names: (Dimethylamino) trimethylsilane; TMS-DMA. Grades: Highly Purified. CAS No. 2083-91-2. Pack Sizes: 25g, 50g, 100g, 250g, 500g. US Biological Life Sciences.
Worldwide
N-(Trimethylsilyl)imidazole
N-(Trimethylsilyl)imidazole. CAS No. 18156-74-6. Cenik is your partner of choice for specialised chemicals. We don't just provide products - we supply solutions to your technical and regulatory specifications.
N-Trimethylsilylimidazole in Anhydrous Pyridine
N-Trimethylsilylimidazole in Anhydrous Pyridine. Uses: For analytical and research use. Alternative Names: SIM (in Anhydrous Pyridine). Catalog: APB01019.
N- (Trimethylsilyl) morpholine
N- (Trimethylsilyl) morpholine. Group: Biochemicals. Grades: Highly Purified. CAS No. 13368-42-8. Pack Sizes: 10g, 25g, 50g, 100g, 250g. US Biological Life Sciences.
Worldwide
N-(Trimethylsilyl)Morpholine
N-(Trimethylsilyl)Morpholine. Alternative Names: N-(TriMethylsilyl)Morpholine; trimethyl(morpholin-4-yl)silane. CAS No. 13368-42-8. Purity: 95%+. Product ID: ACM13368428. Molecular formula: C7H17NOSi. Mole weight: 159.3 g/mol. IUPAC Name: trimethyl(morpholin-4-yl)silane. Alfa Chemistry - ISO 9001:32057 Certified.
A protected intermediate in the preparation of losartan, and losartan derivatives. Group: Biochemicals. Alternative Names: 5-(2-Fluorophenyl)-1-(triphenylmethyl)-1H-tetrazole. Grades: Highly Purified. CAS No. 937636-38-9. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
N-Tritylaniline
Off-white powder, 98%. Synonym: N-(Triphenylmethyl)aniline. CAS No. 4471-22-1. Pack Sizes: Typically in stock: 5g, 25g. Mole weight: 335.45. MP/BP: M.P. 148-149. Order No: FR-0716.
Frinton Laboratories
N-Trityl Candesartan
N-Trityl Candesartan. Uses: For analytical and research use. Alternative Names: 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid. CAS No. 139481-72-4. Molecular formula: C43H34N6O3. Mole weight: 682.27. Catalog: APB139481724.
N-Trityl Candesartan
Candesartan analog as angiotensin II antagonist. Group: Biochemicals. Alternative Names: 2-Ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid. Grades: Highly Purified. CAS No. 139481-72-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
N-Trityl Candesartan Cilexetil
N-Trityl Candesartan Cilexetil is a titrylated impurity and precursor to Candesartan Cilexetil. Group: Biochemicals. Alternative Names: 2-Ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid 1-[[ (Cyclohexyloxy) carbonyl]oxy]ethyl Ester; 2-Ethoxy-1- [ (2'- (1-tri tyl -1H-tetrazol-5-yl ) -1, 1'-biphenyl -4-yl ) methyl ] -7-benzimidazolecarboxyl ic Acid 1- (Cyclohexyl oxycarbonyl oxy) ethyl Ester. Grades: Highly Purified. CAS No. 170791-09-0. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
N-Trityl Candesartan Cilexetil Methoxy Analogue
Precursor to Candesartan Cilexetil Methoxy Analogues. Group: Biochemicals. Alternative Names: 2-Methoxy-1-[[2'-(N-trityl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid 1-[[ (Cyclohexyloxy) carbonyl]oxy]ethyl Ester. Grades: Highly Purified. CAS No. 1246818-56-3. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
N-Trityl Candesartan Ethyl Ester
Candesartan analog as angiotensin II antagonist. Group: Biochemicals. Alternative Names: 2-Ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-. Grades: Highly Purified. CAS No. 856414-35-2. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
N-Trityl Candesartan Methyl Ester-d4
An intermediate in the preparation of labeled Candesartan. Group: Biochemicals. Alternative Names: 2-Ethoxy-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid Methyl Ester-d4; 2-Ethoxy-1- [ (2'- (1-tri tyl -1H-tetrazol-5-yl ) -1, 1'-biphenyl -4-yl ) methyl ] -7-benzimidazolecarboxyl ic Acid Methyl Ester-d4. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
N-Trityl-L-homoserine lactone. Alternative Names: Trt-Hse-lactone; Trt-homoSer-lactone. CAS No. 83427-81-0. Molecular formula: C23H21NO2. Mole weight: 343.43.
N-Trityl Losartan
Intermediate in the preparation of Losartan impurities. Group: Biochemicals. Alternative Names: 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl-4-yl]methyl]-1H-imidazole-5-methanol; Trityllosartan. Grades: Highly Purified. CAS No. 124751-00-4. Pack Sizes: 25mg. US Biological Life Sciences.
Intermediate in the preparation of Losartan metabolites and impurities. Group: Biochemicals. Alternative Names: 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5- β-D-glucuronic Acid Methyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
N-Trityl Losartan Carboxaldehyde
An intermediate in the synthesis of the EXP 3174, a metabolite of Losartan. Group: Biochemicals. Alternative Names: 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-. Grades: Highly Purified. CAS No. 120568-18-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
N-Trityl losartan carboxylic acid
N-Trityl losartan carboxylic acid. Group: Biochemicals. Alternative Names: 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid. Grades: Highly Purified. CAS No. 947331-10-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C41H35ClN6O2. US Biological Life Sciences.
Worldwide
N-Trityl Losartan-d3 Carboxaldehyde
A labeled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan. Group: Biochemicals. Alternative Names: 2-Butyl-d3-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
N-Trityl Losartan-d3 Carboxylic Acid
A Losartan derivative for treatment of hypertension. Group: Biochemicals. Alternative Names: 2-Butyl-d3-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
N-Trityl Losartan-d4
A protected form of labeled Losartan (an antihypertensive). Group: Biochemicals. Alternative Names: 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl-d4]-4-yl]methyl]-1H-imidazole-5-methanol; Trityllosartan-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
N-Trityl Losartan-d4 Carboxaldehyde
A labeled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan. Group: Biochemicals. Alternative Names: 2-Butyl-4-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
N-Trityl Losartan Isomer
Intermediate in the preparation of Losartan impurities. Group: Biochemicals. Alternative Names: 2-Butyl-5-chloro-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-4-methanol. Grades: Highly Purified. CAS No. 133727-10-3. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
N-Trityl-L-proline diethylammonium salt
N-Trityl-L-proline diethylammonium salt. Alternative Names: Trt-Pro-OH DEA; (S)-1-Tritylpyrrolidine-2-carboxylic acid diethylammonium salt. CAS No. 80514-78-9. Molecular formula: C28H34N2O2. Mole weight: 430.58.
N-Trityl-morpholinoguanine
N-Trityl-morpholinoguanine is an extensively studied and widely recognized biomedical compound, exhibiting as a formidable inhibitory compound against select enzymes intricately linked to the pivotal process of DNA synthesis. Alternative Names: 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-, (2R-cis)-. Grades: ≥95%. CAS No. 140679-49-8. Molecular formula: C29H28N6O3. Mole weight: 508.57.
N-Trityl-morpholino-T-5'-O-phosphoramidite
N-Trityl-morpholino-T-5'-O-phosphoramidite is an irreplaceable and significant compound, serving for facilitating the synthesis of oligonucleotides and DNA-modified compounds. Its extensive adoption within pharmaceutical research, dedicated to the innovation of studying diverse ailments such as cancer, genetic disorders and viral infections. Alternative Names: N-Trityl-morpholino-T-7'-O-phosphoramidite; 2-cyanoethyl (((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl) diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl[(2S,6R)-6-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-4-(triphenylmethyl)-2-morpholinyl]methyl ester. Grades: ≥95%. CAS No. 2434654-73-4. Molecular formula: C38H46N5O5P. Mole weight: 683.78.
N-Trityl-morpholino-U-5'-O-phosphoramidite
N-Trityl-morpholino-U-5'-O-phosphoramidite is a crucial component in the biomedical industry for the synthesis of phosphorothioate oligonucleotides. It finds applications in the development of drugs targeting various diseases like cancer, viral infections and genetic disorders. Alternative Names: BP-29998; N-Trityl-morpholino-U-5'-O-phosphoramidite. Grades: ≥95%. Molecular formula: C37H44N5O5P. Mole weight: 669.75.
N-Trityl-N2-isobutyryl-morpholino-G-5'-O-phosphoramidite is a compound, finding extensive employment in the esteemed realm of biomedical industry. This invaluable compound functions as a phosphoramidite compound, enabling the synthesis of nucleosides and nucleotides with tailored modifications. Its indispensible contribution lies in the facilitation of effective assembly of modified oligonucleotides that possess heightened properties and refined specificity. Alternative Names: N-[9-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-cyanoethyl[(2S,6R)-6-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl ester. Grades: ≥95%. Molecular formula: C42H51N8O5P. Mole weight: 778.88.
N-Trityl-N4-benzoyl-morpholino-C-5'-O-phosphoramidite is a crucial compound used in the synthesis of oligonucleotide mimetics and modified nucleotides for biomedical research. It finds application in the development of novel drugs and therapies for studying various diseases, including cancer, viral infections and genetic disorders. Alternative Names: N-[1-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]-2-oxopyrimidin-4-yl]benzamide; Phosphoramidous acid, N,N-bis(1-methylethyl)-, [(2S,6R)-6-[4-(benzoylamino)-2-oxo-1(2H)-pyrimidinyl]-4-(triphenylmethyl)-2-morpholinyl]methyl 2-cyanoethyl ester. Grades: ≥95%. Molecular formula: C44H49N6O5P. Mole weight: 772.87.
N-Trityl-N6-benzoyl-morpholino-A-5'-O-phosphoramidite is a crucial compound used in the biomedical industry for the efficient synthesis of oligonucleotides. This phosphoramidite derivative plays a vital role as a building block during solid-phase synthesis of DNA/RNA fragments, specifically for the research of genetic disorders, viral infections and various types of cancer. Alternative Names: N-[9-[(2R,6S)-6-[[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxymethyl]-4-tritylmorpholin-2-yl]purin-6-yl]benzamide; Phosphoramidous acid, N,N-bis(1-methylethyl)-, [(2S,6R)-6-[6-(benzoylamino)-9H-purin-9-yl]-4-(triphenylmethyl)-2-morpholinyl]methyl 2-cyanoethyl ester. Grades: ≥95%. Molecular formula: C45H49N8O4P. Mole weight: 796.90.
N-Trityl Olmesartan-d6 Ethyl Ester
N-Trityl Olmesartan-d6 Ethyl Ester. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
N-Trityl Olmesartan Ethyl Ester
N-Trityl Olmesartan Ethyl Ester. Group: Biochemicals. Alternative Names: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-. Grades: Highly Purified. CAS No. 172875-59-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
N-Trityl Olmesartan Medoxomil Methyl Ether
N-Trityl Olmesartan Medoxomil Methyl Ether is an intermediate in the synthesis of Olmesartan Medoxomil (O550000), an angiotensin II receptor antagonist used as an anti-hypertensive agent. Group: Biochemicals. Alternative Names: (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-Methoxypropan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
N-Trityl Olmesartan Methyl Ketone
N-Trityl Olmesartan Methyl Ketone is an derivative of Olmesartan Medoxomil (O550000). Olmesartan Medoxomil is an angiotensin II receptor antagonist. Used as an anti-hypertensive agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
N-Trityl O-Methyl Ether Olmesartan Acid
N-Trityl O-Methyl Ether Olmesartan Acid is an intermediate in the synthesis of Olmesartan Acid (O550001), an angiotensin II receptor antagonist used as an anti-hypertensive agent. Group: Biochemicals. Alternative Names: 4-(2-Methoxypropan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic Acid. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
N-Trityl O-Methyl Ether Olmesartan Acid Ethyl Ester is an intermediate in the synthesis of Olmesartan Acid (O550001), an angiotensin II receptor antagonist used as an anti-hypertensive agent. Group: Biochemicals. Alternative Names: Ethyl 4-(2-Methoxypropan-2-yl)-2-propyl-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
N-Trityl-trimethylenediamine, polymer bound
Pre-loaded resins for solid phase peptide and organic synthesis. Alternative Names: 1,3-Diaminopropane trityl resin; N-(3-Aminopropyl)tritylamine, polymer bound.
nTZDpa
nTZDpa. Group: Biochemicals. Grades: Purified. CAS No. 118414-59-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
nTZDpa
nTZDpa is an antibiotic. nTZDpa is a PPARG partial agonist. nTZDpa has antibacterial activity. nTZDpa is effective against growing and persistent Staphylococcus aureus by lipid bilayer disruption[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 118414-59-8. Pack Sizes: 5 mg. Product ID: HY-108569.
NU1025
NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer agents. NU1025 has anti-cancer and neuroprotective activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 90417-38-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15044.
NU1025
NU1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1025 enhanced the cytotoxicity of the DNA-methylating agent MTIC, gamma-irradiation and bleomycin 3.5-, 1.4- and 2-fold respectively. Alternative Names: NU-1025; NU 1025; 8-Hydroxy-2-methylquinazoline-4-one; NSC 696807. Grades: ≥98%. CAS No. 90417-38-2. Molecular formula: C9H8N2O2. Mole weight: 176.17.
NU 1025
NU 1025. Group: Biochemicals. Grades: Purified. CAS No. 90417-38-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NU 2058
NU 2058. Group: Biochemicals. Grades: Purified. CAS No. 161058-83-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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NU223612
NU223612 is a potent PROTAC (PROTACs) that degrades indoleamine 2,3-dioxygenase 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO)) with a Kd of 640 nM. NU223612 potently degrades the IDO1 protein through CRBN-mediated proteasomal degradation. NU223612 is bound to CRBN with an affinity of 290 nM. NU223612 can cross the blood-brain barrier (BBB)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2759420-43-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151886.
NU6027
NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 μM and 1.3 μM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220036-08-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13816.
NU6102
NU6102 is a potent CDK1 and CDK2 inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2 over CDK4 (IC50 of 1.6 μM), DYRK1A (IC50 of 0.9 μM), PDK1 (IC50 of 0.8 μM) and ROCKII (IC50 of 0.6 μM)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 444722-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15569.
NU 6140
NU 6140. Group: Biochemicals. Grades: Purified. CAS No. 444723-13-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NU6300
NU6300 is a covalent, irreversible and ATP-competitive CDK2 inhibitor with an IC50 value of 0.16 μM. NU6300 can be used for the research of eukaryotic cell cycle- and transcription-related[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070015-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18930.
NU 7026
NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY293646. CAS No. 154447-35-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15719.
NU 7026
NU 7026. Group: Biochemicals. Grades: Purified. CAS No. 154447-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
NU7441
NU7441 is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. NU7441 appreciably increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. In mice bearing SW620 xenografts, NU7441 concentrations in the tumor necessary for chemopotentiation in vitro were maintained for at least 4 hours at nontoxic doses. NU7441 increased etoposide-induced tumor growth delay 2-fold without exacerbating etoposide toxicity to unacceptable levels. In conclusion, NU7441 shows sufficient proof of principle through in vitro and in vivo chemosensitization and radiosensitization to justify further development of DNA-PK inhibitors for clinical use. Alternative Names: NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. Grades: 98%. CAS No. 503468-95-9. Molecular formula: C25H19NO3S. Mole weight: 413.49.
NU7441 (KU-57788)
NU7441 (KU-57788) is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits mTOR and PI3K with IC50 of 1.7 μM and 5 μM in cell-free assays, respectively. It reduces the frequency of NHEJ while increasing the rate of HDR following Cas9-mediated DNA cleavage. Group: Inhibitors. CAS No. 503468-95-9. Pack Sizes: 5mg. Product ID: S2638. Formula: C25H19NO3S. Smiles: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56. Storage Conditions: 2 years -80 in solvent.
United States; Europe
NU9056
NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an [1][2] of 2 μM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1450644-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110127.