A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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| Product | Description | |
|---|---|---|
| PLK1/BRD4-IN-5 | PLK1/BRD4-IN-5 (Compound SC10) is an orally active PLK1 and BRD4 inhibitor with IC50 values of 0.3 ?nM and 60.8? nM, respectively. PLK1/BRD4-IN-5 can induce MV4-11 cell block in S phase and apoptosis) in a dose-dependent manner. PLK1/BRD4-IN-5 can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3063893-60-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158031. |  |
| PLLA-PEG-PLLA | CD Bioparticles provides PLLA-PEG-PLLA, Triblock Copolymers with a PEG molecular weight of 1,000 Da and PLA molecular weight of 1,000 Da for drug delivery. Group: Triblock copolymers. |  |
| PLL coated Fe2O3 nanoparticles | PLL coated Fe2O3 nanoparticles. CAS No. 1317-61-9. |  |
| PLL-FITC | Augment your research on Biodegradable Polymers with the reliable PLL-FITC from CD Bioparticles Drug Delivery. Group: Fluorescent polylactides. | |
| PLL-g-N3 | Augment your research on Biopolymers & Synthetic Polymers with the reliable Poly-L-lysine Azide grafted from CD Bioparticles Drug Delivery. Group: Side-functionalized homopolyamino acids. | |
| PLL-g-PEG-Biotin | PLL-g-PEG-Biotin is a biotinylated poly-L-lysine PEG conjugate that was made from the covalent attachment of PEG 2000 and biotin to the Poly-L-lysine molecules. It is a positively charged PLL-g-PEG copolymer that can bind to streptavidin or avidin with high affinity. It is a linear amphiphilic block copolymer used for gene transfection or surface modification. Alternative Names: Poly(L-lysine)-graft-biotinylated PEG; Biotinylated PLL-g-PEG; Poly lysine-g-polyethylene glycol-biotin. |  |
| PLL-g-PEG-N3 | Augment your research on Biopolymers & Synthetic Polymers with the reliable Poly-L-lysine graft PEG-azide from CD Bioparticles Drug Delivery. Group: Pegylated polyamino acids. | |
| PLL HBr-FITC | Augment your research on Biodegradable Polymers with the reliable Poly(L-lysine hydrobromide) Fluorescein from CD Bioparticles Drug Delivery. Group: Custom polyamino acids. | |
| PLL HBr-N3 | Augment your research on Biodegradable Polymers with the reliable Poly-L-lysine hydrobromide Azide from CD Bioparticles Drug Delivery. Group: End-functionalized homopolyamino acids. | |
| PLL HCl | Augment your research on Biodegradable Polymers with the reliable Poly-L-lysine Hydrochloride from CD Bioparticles Drug Delivery. Group: Homopolyamino acids. | |
| PLN-1474 | PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder. Uses: Scientific research. Category: Signaling pathways. CAS No. 2408065-32-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-47888. | |
| PlnA-17 | PlnA-17 is an antibacterial peptide isolated from Lactobacillus plantarum. It has activity against gram-positive bacteria. Grades: >95%. Molecular formula: C97H153N25O20. Mole weight: 1989.44. | |
| PlnA-22 | PlnA-22 is an antibacterial peptide isolated from Lactobacillus plantarum. It has activity against gram-positive bacteria. Alternative Names: Tyr-Ser-Leu-Gln-Met-Gly-Ala-Thr-Ala-Ile-Lys-Gln-Val-Lys-Lys-Leu-Phe-Lys-Lys-Trp-Gly-Trp. Grades: >97%. Molecular formula: C125H195N31O28S. Mole weight: 2612.17. | |
| Plogosertib | Plogosertib (CYC140) is a selective, potent, and orally active ATP-competitive PLK1 inhibitor (IC50: 3 nM). Plogosertib is an anti-cancer agent with anti-proliferative activity. Plogosertib can be used in the research of several tumors, including esophageal, gastric, leukemia, non-small cell lung cancer, ovarian, and squamous cell cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CYC140. CAS No. 1137212-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147298. | |
| Plonmarlimab | Plonmarlimab (TJ003234) is an anti-GM-CSF monoclonal antibody. Plonmarlimab can be used for research of rheumatoid arthritis and COVID-19[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TJ003234; TJM2. CAS No. 2377482-36-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99779. | |
| Plozalizumab | Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MLN-1202. CAS No. 1610761-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99781. | |
| Plozasiran | Plozasiran is an siRNA targeting APOC3 for the study of mixed hyperlipidemia. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARO-APOC3. CAS No. 2379776-40-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-164740. | |
| Plozasiran sodium | Plozasiran sodium is an siRNA targeting APOC3 for the study of mixed hyperlipidemia. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARO-APOC3 sodium. CAS No. 2379776-41-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-164740A. | |
| PLP (103-116) | PLP (103-116) is the 103-116 amino acid residue of myelin protein (PLP), used to induce experimental autoimmune encephalomyelitis (EAE). Alternative Names: PLP 103-116; Tyr-Lys-Thr-Thr-Ile-Cys-Gly-Lys-Gly-Leu-Ser-Ala-Thr-Val. Molecular formula: C63H108N16O20S. Mole weight: 1441.60. | |
| PLP (139-151) | PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). Uses: Scientific research. Category: Induced disease models products. CAS No. 131334-43-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0129. | |
| PLP (139-151) | PLP (139-151). Group: Biochemicals. Grades: Purified. CAS No. 122018-58-0. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| PLP 139-151 | PLP 139-151 is the 139-151 amino acid residue of myelin protein (PLP), used to induce experimental autoimmune encephalomyelitis (EAE). Alternative Names: Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat); His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe; L-histidyl-L-cysteinyl-L-leucyl-glycyl-L-lysyl-L-tryptophyl-L-leucyl-glycyl-L-histidyl-L-prolyl-L-alpha-aspartyl-L-lysyl-L-phenylalanine. Grades: >98%. CAS No. 131334-43-5. Molecular formula: C72H104N20O16S. Mole weight: 1537.79. | |
| PLpro inhibitor | PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 μM[1]. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 μM and an EC50 of 21.0 μM[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1093070-14-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17542. | |
| Plumbagin | Plumbagin, a natural 1,4-naphthoquinone first isolated from plants of the genus Plumbago, induces apoptosis in cancer cells. Plumbagin exhibited effective cell growth inhibition via inducing cancer cells to undergo G2/M phase arrest and apoptosis. Alternative Names: 5-Hydroxy-2-methyl-1,4-naphthalenedione; 2-Methyljuglone; 5-Hydroxy-2-methyl-1,4-naphthoquinone; NSC 236613; NSC 688284; Plumbagine; Plumbagone. Grades: ≥98% by HPLC. CAS No. 481-42-5. Molecular formula: C11H8O3. Mole weight: 188.18. | |
| Plumbagin | Plumbagin. Group: Biochemicals. Grades: Purified. CAS No. 481-42-5. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Plumbagin | Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities[1]. Uses: Scientific research. Category: Natural products. Alternative Names: 2-Methyljuglone. CAS No. 481-42-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N1497. | |
| Plum extract | Plum Extract is a botanical derivative derived from plums. This natural compound has garnered significant attention for its remarkable antioxidative properties aiding in studying ailments associated with oxidative stress, including cardiovascular afflictions, diabetes and select malignancies. Alternative Names: prunus domestica fruit extract. CAS No. 90082-87-4. | |
| Plumieride | Plumieride is isolated from the herb of Himatanthus fallax. It shows strong fungitoxicity against some dermatophytes. Alternative Names: Agoniadin. Grades: 98%. CAS No. 511-89-7. Molecular formula: C21H26O12. Mole weight: 470.42. | |
| Pluracidomycin A1 | Pluracidomycin A1 is a carbapenem antibiotic produced by Str. pluracidomyceticus nov. sp. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase. Alternative Names: 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 7-oxo-3-sulfo-6-(1-(sulfooxy)ethyl)-, (5R-(5alpha,6beta(S*)))-; Pluracidomycin; Pluracidomycin A; SF 2103 A. Grades: >98%. CAS No. 82138-64-5. Molecular formula: 9H11NO10S2. Mole weight: 357.31. | |
| Pluracidomycin B | Pluracidomycin B is a carbapenem antibiotic produced by Str. pluracidomyceticus nov. sp. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase. CAS No. 82138-65-6. Molecular formula: C11H13NO10S2. Mole weight: 383.35. | |
| Pluracidomycin C1 | Pluracidomycin C1 is a carbapenem antibiotic produced by Str. pluracidomyceticus nov. sp. It has anti-gram-positive bacteria and gram-negative bacteria activity, and has the effect of inhibiting β-lactamase. Alternative Names: Pluracidomycin C. CAS No. 82138-66-7. Molecular formula: C10H13NO10S2. Mole weight: 371.34. | |
| Pluraflavin A | Pluraflavin A is an antitumor antibiotic produced by Saccharothrix sp. DSM 12931. Pluraflavin A has the effect of inhibiting the transcription of glucose-6-phosphatase gene and has good anti-proliferation activity on tumor cells. Molecular formula: C43H54N2O14. Mole weight: 822.89. | |
| Pluraflavin C | Pluraflavin C is an antitumor antibiotic produced by Saccharothrix sp. DSM 12931. It has good anti-proliferation activity on tumor cells. Molecular formula: C43H56N2O15. Mole weight: 840.91. | |
| Pluraflavin E | Pluraflavin E is an antitumor antibiotic produced by Saccharothrix sp. DSM 12931. It has good anti-proliferation activity on tumor cells. Molecular formula: C36H41NO14. Mole weight: 711.71. | |
| Pluripotin | Pluripotin is a dual inhibitor of ERK1 and RasGAP with KDs of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC50s of 0.5, 2.5, 3.3, and 10.0 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SC1. CAS No. 839707-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10579. | |
| Pluripotin | SC1 (Pluripotin) was identified in a cell-based chemical library screen for small molecules that regulate mouse embryonic stem (ES) cell self-renewal. SC1 is sufficient to sustain long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of extracellular signal-regulated kinase 1 (ERK1) and Ras GTPase-activating protein (Ras-GAP). Mouse ES cells maintained in the presence of SC1 retain their ability to differentiate into cells representing all three germ layers in vitro, form chimeric mouse, and contribute to germ line in vivo. Uses: Self-renewal. Alternative Names: SC-1; SC 1; SC1; Pluripotin. Grades: 0.98. CAS No. 839707-37-8. Molecular formula: C27H25F3N8O2. Mole weight: 550.54. | |
| Pluripotin | Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Pluripotin has been shown to maintain embryonic stem cell (ESC) self-renewal. When combined with leukemia inhibitory factor, Pluripotin greatly promotes derivation of embryonic stem cell lines from refractory strains. Group: Biochemicals. Alternative Names: N-[3-[7-[ (1, 3-Dimethyl-1H-pyrazol-5-yl) amino]-1, 4-dihydro-1-methyl-2-oxopyrimido[4, 5-d]pyrimidin-3 (2H) -yl]-4-methylphenyl]-3- (trifluoromethyl) benzamide; N-[3-[7- (2, 5-Dimethyl-2H-pyrazol-3-ylamino) -1-methyl-2-oxo-1, 4-dihydro-2H-pyrimido[4, 5-d]pyrimidin-3-yl]-4-methylphenyl]-3-trifluoromethyl-benzamide; SC 1; Stemolecule SC 1. Grades: Highly Purified. CAS No. 839707-37-8. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| PluriSIn 1 | PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 14613. CAS No. 91396-88-2. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-15700. | |
| PluriSIn #2 | PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56563-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111630. | |
| Pluronic F-127 | 100g Pack Size. Group: Detergents. Formula: (C3H6O ·C2H4O)x. CAS No. 9003-11-6. Prepack ID 90030405-100g. Molecular Weight 304.29. See USA prepack pricing. |  |
| Pluronic F-127 | Pluronic F-127 is a nonionic, surfactant polyol (molecular weight approximately 12,500 daltons) that has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological media. Group: Biochemicals. Alternative Names: Poloxamer 407. Grades: Cell Culture Grade. CAS No. 9003-11-6. Pack Sizes: 250g, 500g, 1Kg. Molecular Formula: (C3H6O·C2H4O)x, Molecular Weight: Polymer. US Biological Life Sciences. | Worldwide |
| Pluronic F-127, 20% DMSO | Pluronic F-127 in DMSO is a nonionic, surfactant polyol (molecular weight approximately 12,500 daltons) that has been found to facilitate the solubilization of water-insoluble dyes and other materials in physiological media. Pluronic F-127 is commonly used to help disperse the acetoxymethyl (AM) esters of our ion indicators as well as our cell tracer dyes such as CFDA-SE.Pluronic F-127 (Poloxamer 407) is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol. The approximate lengths of the two PEG blocks is 101 repeat units while the approximate length of the propylene gycol block is 56 repeat units. Group: Biochemicals. Alternative Names: Poloxamer 407; Synperonic PE/F 127. Grades: Purified. CAS No. 9003-11-6. Pack Sizes: 10ml, 25ml, 50ml. Molecular Formula: (C3H6O·C2H4O)x. US Biological Life Sciences. | Worldwide |
| Pluronic F-68 | 500g Pack Size. Group: Analytical Reagents, Biochemicals, Building Blocks, Diagnostic Raw Materials. Formula: (C3H6OC2H4O)x. CAS No. 9003-11-6. Prepack ID 89483155-500g. See USA prepack pricing. | |
| plus-end-directed kinesin ATPase | Microtubular motor protein, involved in organelle movement, in mitosis and meiosis. In contrast to dynein, it moves along microtubules towards the plus end. Composed of two heavy (α) chains (110 kDa) and two or more light (β) chains (65-75 kDa). Also hydrolyses GTP. Group: Enzymes. Synonyms: kinesin. Enzyme Commission Number: EC 3.6.4.4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4706; plus-end-directed kinesin ATPase; EC 3.6.4.4; kinesin. Cat No: EXWM-4706. |  |
| Plutonium dioxide238 | Plutonium dioxide238. CAS No. 13981-16-3. Product ID: ACM13981163. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Plutonium dioxide239 | Plutonium dioxide239. CAS No. 15117-48-3. Product ID: ACM15117483. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Pluviatolide | Pluviatolide is a butyrolactone lignan first isolated from the Australian native plant, Zanthoxylum pluviatile. It has a variety of biological activities, including antioxidant, enzyme inhibitory effect and antispasmodic properties. Alternative Names: (-)-Pluviatolide; 2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)dihydro-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3R-trans)-; 3α-(4-Hydroxy-3-methoxybenzyl)-4β-(1,3-benzodioxole-5-ylmethyl)-4,5-dihydrofuran-2(3H)-one; 4,5-Dihydro-4β-[(1,3-benzodioxole-5-yl)methyl]-3α-(4-hydroxy-3-methoxybenzyl)furan-2(3H)-one; trans-Pluviatolide; (3R,4R)-4-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-hydroxy-3-methoxybenzyl)dihydrofuran-2(3H)-one. Grades: ≥95% by HPLC. CAS No. 28115-68-6. Molecular formula: C20H20O6. Mole weight: 356.37. | |
| PLX-3618 | PLX-3618 is a molecular glue, that degrades BRD4 with DC50 of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851986-76-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161779. | |
| Plx-4032 | Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma. Category: Active pharmaceutical ingredients. CAS No. 1029872-54-5. Product ID: API1029872545. Molecular formula: C23H18ClF2N3O3S. Mole weight: 489.92. |  |
| PLX4032 (Vemurafenib) | Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy. Group: Inhibitors. Alternative Names: RG7204, RO5185426,PLX4032. CAS No. 918504-65-1. Pack Sizes: 10mg. Product ID: S1267. Formula: C23H18ClF2N3O3S. Smiles: CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F. Storage Conditions: 3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent. |  United States; Europe |
| PLX-4545 | PLX-4545 is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PLX-4545 binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (Treg) into effector-like T cells, enhances CD8+ T cell responses, and modulates the Teff:Treg balance. PLX-4545 also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of Treg. PLX-4545 can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1[1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2892065-45-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159647. | |
| PLX4720 | Potent and selective cell permeable B-Raf (V600E) and c-Raf-1 (Y340D/Y341D) inhibitor. Antitumor compound. ERK phosphorylation is potently inhibited exclusive in B-Raf(V600E)-bearing tumor cell lines. Group: Biochemicals. Alternative Names: N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide, Raf Kinase Inhibitor V. Grades: Highly Purified. CAS No. 918505-84-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??ClF?N?O?S. US Biological Life Sciences. | Worldwide |
| PLX-4720 | PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf. Uses: Scientific research. Category: Signaling pathways. CAS No. 918505-84-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-51424. | |
| PLX51107 | PLX51107 is a potent and selective BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2). It blocks the interaction mediated by the four BET family proteins. Alternative Names: (S)-4-(6-(3,5-dimethylisoxazol-4-yl)-1-(1-(pyridin-2-yl)ethyl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid; PLX 51107; PLX-51107. CAS No. 1627929-55-8. Molecular formula: C26H22N4O3. Mole weight: 438.48. | |
| PLX51107 | PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range). Uses: Scientific research. Category: Signaling pathways. CAS No. 1627929-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111422. | |
| PLX5622 | PLX5622 is a highly selective CSF-1R inhibitor (IC50 ?20-fold selectivity over KIT and FLT3. Group: Inhibitors. CAS No. 1303420-67-8. Pack Sizes: 2mg. Product ID: S8874. Formula: C21H19F2N5O. Smiles: CC1=CC2=C(NC=C2CC3=C(N=C(C=C3)NCC4=C(N=CC(=C4)F)OC)F)N=C1. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| PLX5622 | PLX5622 is a highly selective and orally active CSF-1R inhibitor with IC50 < 10 nmol/L. Alternative Names: PLX-5622; PLX5622 free base; 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine. Grades: 98%. CAS No. 1303420-67-8. Molecular formula: C21H19F2N5O. Mole weight: 395.41. | |
| PLX5622 | PLX5622 Inhibitor. Uses: Scientific use. Product Category: T7100. CAS No. 1303420-67-8. |  |
| PLX5622 | PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 μM; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 1303420-67-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-114153. | |
| PLX5622 hemifumarate | PLX5622 hemifumarate, a highly selective brain penetrant and orally active CSF1R inhibitor (IC50 = 0.016 μM; Ki = 5.9 nM), allows for extended and specific microglial elimination, preceding and during pathology development. It exhibits desirable PK properties in varies animals. Alternative Names: 5-fluoro-N-[6-fluoro-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-2-methoxy-3-pyridinemethanamine hemifumarate. Grades: ≥99%. Molecular formula: C21H19F2N5O.(1/2C4H4O4). Mole weight: 453.45. | |
| PLX647 | PLX647 is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, respectively. PLX647 shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873786-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13838. | |
| PLX-647 | PLX-647 is PLX647 is a potent inhibitors of both FMS and KIT that show strong selectivity compared with other kinases. In the in vitro enzymatic assay, PLX647 inhibits FMS with IC50 = 0.028μM and KIT with IC50 = 0.016 μM. PLX647 represents a unique class of kinase inhibitors with unique dual FMS and KIT specificity. Alternative Names: PLX-647; PLX 647; PLX647. Grades: 0.98. CAS No. 873786-09-5. Molecular formula: C21H17F3N4. Mole weight: 382.39. | |
| PLX 647 dihydrochloride | PLX 647 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PLX7922 | PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1638772-61-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-107415. | |
| PM-1 | PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1449483-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156404. | |
| PM 102 | PM 102, an antagonist of heparin, is a peptide that reverses the anticoagulant effect of heparin. Alternative Names: PM 102; PM102; PM-102; AEARARRAAARAARRAKK(AEARARRAAARAARRA)PX(AEARARRAAARAARRA)EN. CAS No. 1234564-95-4. Molecular formula: C235H425N111O64. Mole weight: 5830. | |
| PM-43I | PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1637532-77-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148092. | |
| PM-94128 | PM-94128. Alternative Names: PM 94128; PM94128. CAS No. 182292-49-5. Molecular formula: C22H34N2O6. Mole weight: 422.5. | |
| PMA | PMA, extracted from seeds of Euphorbia lathyris L, is a phorbol ester that is commonly used to activate certain types of protein kinase C (PKC), including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. Alternative Names: Phorbol-12-Myristate-13-Acetate; 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate; 12 Myristoyl 13 acetylphorbol; 12 O Tetradecanoyl Phorbol 13 Acetate; 12-Myristoyl-13-acetylphorbol; 12-O-Tetradecanoyl Phorbol 13-Acetate; 13-Acetate, 12-O-Tetradecanoyl Phorbol; Acetate, Phorbol Myristate; Acetate, Tetradecanoylphorbol; Myristate Acetate, Phorbol; Phorbol 13-Acetate, 12-O-Tetradecanoyl; Phorbol Myristate Acetate; Tetradecanoylphorbol Acetate; Tetradecanoylphorbol Acetate, 4a alpha Isomer; Tetradecanoylphorbol Acetate, 4a alpha-Isomer. Grades: ≥95%. CAS No. 16561-29-8. Molecular formula: C36H56O8. Mole weight: 616.83. | |
| PMA chemical (Phorbol 12-myristate 13-acetate) | PMA (Phorbol 12-myristate 13-acetate), a potent activator of PKC, is active at nanomolar concentrations. Phorbol 12-myristate 13-acetate (PMA) induces sphingosine-1-phosphate (S1P).PMA has strong excitability on the skin and mucous membrane. Special protection is required when using PMA. Wear gloves and mask to avoid direct contact in any way. Group: Inhibitors. Alternative Names: 12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate. CAS No. 16561-29-8. Pack Sizes: 5mg. Product ID: S7791. Formula: C36H56O8. Smiles: CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C. | United States; Europe |
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