A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Pitavastatin Impurity 93. Uses: For analytical and research use. Alternative Names: methyl 2-((4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate. Molecular formula: C10H16O5. Mole weight: 216.23. Catalog: APB01411.
Pitavastatin Impurity 96
Pitavastatin Impurity 96. Uses: For analytical and research use. Alternative Names: Calcium (3R,6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3-quinolinyl]-3-hydroxy-5-oxo-6-heptenoate; calcium (R,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3-hydroxy-5-oxohept-6-enoate. CAS No. 2180095-22-9. Molecular formula: C25H21FNO4·1/2Ca. Mole weight: 438.38. Catalog: APB2180095229.
Pitavastatin Impurity 98
Pitavastatin Impurity 98. Uses: For analytical and research use. Alternative Names: 2-cyclopropyl-4-(2-fluorophenyl)quinoline-3-carbaldehyde. Molecular formula: C19H14FNO. Mole weight: 291.32. Catalog: APB01410.
Pitavastatin lactone
Pitavastatin lactone is a major metabolite of Pitavastatin (HY-B0144A) in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 141750-63-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125643.
Pitavastatin Lactone-[d4]
One of the isotopic labelled metabolites of Pitavastatin, which has a potent cholesterol-lowering action. Synonyms: Pitavastatin Lactone D4. Grade: >98%. Molecular formula: C25H18D4FNO3. Mole weight: 407.48.
Pitavastatin magnesium
Pitavastatin magnesium is an orally active HMG-CoA Reductase inhibitor. Pitavastatin magnesium lowers total cholesterol and low-density lipoprotein cholesterol in a hyperlipidemic rat model. Pitavastatin magnesium can be used in research on cardiovascular and cerebrovascular diseases such as hyperlipidemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 956116-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108744.
Pitavastatin (NK-104) Calcium
Pitavastatin calcium, a novel member of the medication class of statins, is a calcium salt formulation of pitavastatin which is a highly effective HMG-CoA reductase inhibitor. Pitavastatin Calcium attenuates AGEs-induced mitophagy via inhibition of ROS generation. Pitavastatin Calcium induces autophagy and apoptosis. Group: Inhibitors. Alternative Names: NK-104 calcium. CAS No. 147526-32-7. Pack Sizes: 50mg. Product ID: S1759. Formula: C50H46CaF2N2O8. Smiles: C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Pitavastatin Oxidation Impurity 1
Pitavastatin Oxidation Impurity 1. Uses: For analytical and research use. Alternative Names: (E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dioxohept-6-enoic acid. Molecular formula: C25H20FNO4. Mole weight: 417.43. Catalog: APB01408.
PITCOIN4
PITCOIN4 is a highly selective Class II Alpha PI3K-C2α inhibitor. PITCOIN4 shows nanomolar inhibition of PI3K-C2α and >100-fold selectivity in a general kinase panel[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032439-98-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156406.
Pitofenone Hydrochloride
Diclofenac and its combination with Pitofenone and Fenpiverinium. Group: Biochemicals. Alternative Names: 2-[4-[2- (1-Piperidinyl) ethoxy]benzoyl]benzoic Acid. Grades: Highly Purified. CAS No. 1248-42-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Pitolisant
Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tiprolisant. CAS No. 362665-56-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12199.
Pitolisant hydrochloride
Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ciproxidine; BF 2649. CAS No. 903576-44-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12199B.
pitrilysin
From the periplasmic space of Escherichia coli. Inhibited by EDTA and 1,10-phenanthroline; not thiol-dependent. Type example of peptidase family M16. Group: Enzymes. Synonyms: Escherichia coli protease III; protease Pi; proteinase Pi; PTR; Escherichia coli metalloproteinase Pi. Enzyme Commission Number: EC 3.4.24.55. CAS No. 81611-78-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4337; pitrilysin; EC 3.4.24.55; 81611-78-1; Escherichia coli protease III; protease Pi; proteinase Pi; PTR; Escherichia coli metalloproteinase Pi. Cat No: EXWM-4337.
Pitstop 2
Pitstop 2 is an inhibitor of the interaction of amphiphysin with the amino terminal domain of clathrin that inhibits both clathrin-dependent endocytosis (CDE) and clathrin independent endocytosis (CIE). Group: Inhibitors. CAS No. 1332879-52-3. Pack Sizes: 5mg. Product ID: S9670. Formula: C20H13BrN2O3S2. Smiles: BrC1=CC=C(C=C1)\C=C2/SC(=NC2=O)N[S](=O)(=O)C3=CC=CC4=C3C=CC=C4. Storage Conditions: 3 years -20°C powder.
United States; Europe
Pitstop 2
Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1419320-73-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115604.
Pittosapogenin
Pittosapogenin is a triterpenoid compound. CAS No. 15399-43-6. Molecular formula: C30H50O6. Mole weight: 506.71.
Pittsburgh Compound B
Pittsburgh Compound B (PiB) is a blood-brain barrier-permeable, specific Aβ deposition PET tracer that binds to Aβ(1-40) fibrils with a Ki value of 678.4 nM. Through click chemical modification (a clickable Pittsburgh Compound B derivative is prepared by introducing a PEG3 linker and an alkynyl group at the 6-hydroxy site of Pittsburgh Compound B, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and enrichment and characterization of Aβ complexes. Pittsburgh Compound B is applicable to Alzheimer's disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PiB; 6-OH-BTA-1. CAS No. 566169-93-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126192.
White powder, 98%. Synonym: 2,2-Dimethylpropionamide. CAS No. 754-10-9. Pack Sizes: Typically in stock: 25g, 100g. Mole weight: 101.15. MP/BP: M.P. 154-155. Order No: FR-0367.
Frinton Laboratories
Pivalanilide
Crystalline powder, 98%. Synonym: N-Phenylpivalamide. CAS No. 6625-74-7. Pack Sizes: Typically in stock: 5g, 25g. Mole weight: 177.25. MP/BP: M.P. 130-133. Order No: FR-0364.
Frinton Laboratories
Pivalic Acid
Pivalic Acid is a metabolite of oral cephem ( β-lactam) antibiotics such as S-1108, containing pivaloyl moieties. Group: Biochemicals. Alternative Names: 2,2-Dimethylpropanoic Acid; 2,2,2-Trimethylacetic Acid; 2,2-Dimethylpropanoic Acid; 2,2-Dimethylpropionic Acid; NSC 65449; Neopentanoic Acid; Neovaleric Acid; Trimethylacetic Acid; Tri methyl methanecarboxylic Acid; Versatic 5 Acid; tert-Pentanoic Acid; α,α-Dimethylpropionic Acid. Grades: Highly Purified. CAS No. 75-98-9. Pack Sizes: 10g. US Biological Life Sciences.
Worldwide
Pivalic acid-d9
Pivalic acid-d9 is the deuterium labeled Pivalic acid[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trimethylmethanecarboxylic acid-d9; Versatic 5 acid-d9; tert-Pentanoic acid-d9. CAS No. 42983-07-3. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Y1150S2.
Pivalic acid hydrazide
Pivalic acid hydrazide. Group: Biochemicals. Grades: Highly Purified. CAS No. 42826-42-6. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
Pivalonitrile
Pivalonitrile. Group: Biochemicals. Alternative Names: Trimethylacetonitrile. Grades: Highly Purified. CAS No. 630-18-2. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C5H9N. US Biological Life Sciences.
Worldwide
Pivaloylacetonitrile
Pivaloylacetonitrile. Group: Biochemicals. Grades: Highly Purified. CAS No. 59997-51-2. Pack Sizes: 1kg, 2kg, 5kg, 10kg, 25kg. US Biological Life Sciences.
Worldwide
Pivampicillin Hydrochloride
Semi-synthetic antibiotic related to Penicillin. Antibacterial. Group: Biochemicals. Alternative Names: (2S, 5R, 6R)-6-[[(2R)-2-Amino-2-phenylacetyl]amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic Acid (2,2-Dimethyl-1-oxopropoxy)methyl Ester Hydrochloride Alphacilina; Alphacillin; Ampicillin Pivaloxyoxymethyl Ester Hydrochloride; Berocillin; Centurina; Diancina; Inacilin; Maxifen; Pivaloyloxymethyl D- (-) - α -Aminophenyl acetamidopenicillanate Hydrochloride; Pivatil; Pondocil; Pondocillin; Pondocillina; Sanguicillin. Grades: Purified. CAS No. 26309-95-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Pivarose
Pivarose (Phenyl Ethyl Pivalate). CAS No. 67662-96-8. Kosher: Y. VIGON Item # 500875. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers.
America & Internationally
Pivekimab
Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate (ADC). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2234335-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99234.
Pividium bromide impurity 10
Pividium bromide impurity 10. Uses: For analytical and research use. CAS No. 1970218-70-2. Molecular formula: C26H41Br2NO4. Mole weight: 591.43. Catalog: APB1970218702.
Pividium bromide impurity 11
Pividium bromide impurity 11. Uses: For analytical and research use. Molecular formula: C15H23Br2NO4. Mole weight: 441.16. Catalog: APB11355.
Pividium bromide impurity 12
Pividium bromide impurity 12. Uses: For analytical and research use. Molecular formula: C15H22BrClNO3+. Mole weight: 379.7. Catalog: APB11357.
Pividium bromide impurity 13
Pividium bromide impurity 13. Uses: For analytical and research use. Molecular formula: C27H41Br2NO3. Mole weight: 587.44. Catalog: APB11356.
Pividium bromide impurity 14
Pividium bromide impurity 14. Uses: For analytical and research use. CAS No. 53207-00-4. Molecular formula: C9H10Br2O2. Mole weight: 309.99. Catalog: APB53207004.
Pividium bromide impurity 15
Pividium bromide impurity 15. Uses: For analytical and research use. CAS No. 1235355-01-7. Molecular formula: C26H39Br2NO4. Mole weight: 589.41. Catalog: APB1235355017.
Pividium bromide impurity 16
Pividium bromide impurity 16. Uses: For analytical and research use. Molecular formula: C17H31NO2. Mole weight: 281.44. Catalog: APB11358.
Pividium bromide impurity 17
Pividium bromide impurity 17. Uses: For analytical and research use. Molecular formula: C11H20O. Mole weight: 168.28. Catalog: APB11359.
Pividium bromide impurity 2
Pividium bromide impurity 2. Uses: For analytical and research use. CAS No. 473-00-7. Molecular formula: C11H16. Mole weight: 148.25. Catalog: APB473007.
Pividium bromide impurity 3
Pividium bromide impurity 3. Uses: For analytical and research use. Molecular formula: C11H20O2. Mole weight: 184.28. Catalog: APB11352.
Pividium bromide impurity 4
Pividium bromide impurity 4. Uses: For analytical and research use. Molecular formula: C11H18O. Mole weight: 166.26. Catalog: APB11351.
Pividium bromide impurity 5
Pividium bromide impurity 5. Uses: For analytical and research use. Molecular formula: C12H20O2. Mole weight: 196.29. Catalog: APB11353.
Pividium bromide impurity 6
Pividium bromide impurity 6. Uses: For analytical and research use. CAS No. 64773-71-3. Molecular formula: C11H18O. Mole weight: 166.26. Catalog: APB64773713.
Pividium bromide impurity 7
Pividium bromide impurity 7. Uses: For analytical and research use. CAS No. 7712-52-9. Molecular formula: C17H29NO2. Mole weight: 279.42. Catalog: APB7712529.
Pividium bromide impurity 8
Pividium bromide impurity 8. Uses: For analytical and research use. Molecular formula: C26H41BrNO4+. Mole weight: 511.52. Catalog: APB11354.
Pividium bromide impurity 9
Pividium bromide impurity 9. Uses: For analytical and research use. CAS No. 135964-95-3. Molecular formula: C26H41Br2NO4. Mole weight: 591.43. Catalog: APB135964953.
Pivmecillinam Hydrochloride
Pivmecillinam Hydrochloride. Group: Biochemicals. Alternative Names: (2S, 5R, 6R)-6-[[(Hexahydro-1H-azepin-1-yl)methylene]amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3. 2. 0]heptane-2-carboxylic Acid (2,2-Dimethyl-1-oxopropoxy)methyl Ester Hydrochloride. Grades: Highly Purified. CAS No. 32887-03-9. Pack Sizes: 50mg. Molecular Formula: C21H34ClN3O5S, Molecular Weight: 476.03. US Biological Life Sciences.
Worldwide
Pixantrone
Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BBR 2778. CAS No. 144675-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13727A.
Pixantrone Impurity 1
Pixantrone Impurity 1. Uses: For analytical and research use. CAS No. 144510-98-5. Molecular formula: C17H17N3O4. Mole weight: 327.34. Catalog: APB144510985.
Pixantrone Impurity 2
Pixantrone Impurity 2. Uses: For analytical and research use. CAS No. 1430561-04-8. Molecular formula: C15H14N4O2. Mole weight: 282.3. Catalog: APB1430561048.
Pizotifen
Pizotifen (Pizotyline) is a potent 5-HT2 receptor antagonist, with a high affinity for 5-HT1C binding site. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pizotyline; BC-105. CAS No. 15574-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-B0115.
Pizotifen malate
1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C19H21NS.C4H6O5. CAS No. 5189-11-7. Prepack ID 12889487-1g. Molecular Weight 429.53. See USA prepack pricing.
Pizotyline
Serotonin antagonist structurally related to Cyproheptadine. Antimigraine; appetite stimulant. Group: Biochemicals. Alternative Names: 4-(9, 10-Dihydro-4H-benzo[4, 5]cyclohepta[1, 2-b]thien-4-ylidene)-1-methylpiperidine. Grades: Highly Purified. CAS No. 15574-96-6. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
PJ34
PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 344458-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-13688A.
PJ 34 Hydrochloride
A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. Group: Biochemicals. Alternative Names: N- (5, 6-Dihydro-6-oxo-2-phenanthridinyl) -2- (dimethylamino) acetamide. Grades: Highly Purified. CAS No. 344458-15-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
PJ-34 Hydrochloride
A potent, water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC50 = 20nM). Inhibits peroxynitrite-induced cell necrosis and displays significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Suppresses cell growth in liver cancer cells. Group: Biochemicals. Alternative Names: N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Potent, water soluble poly(ADP-ribose) polymerase (PARP) inhibitor. Inhibits peroxynitrite-induced cell necrosis. Shows significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Shows protective effects in models of stroke. Suppresses cell growth in liver cancer cells. Group: Biochemicals. Alternative Names: N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide. HCl. Grades: Highly Purified. CAS No. 344458-15-7. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences.
Worldwide
pJAK2(1001-1013)
pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a SOCS1/3antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259928-08-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10373.
PK11007
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 874146-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128784.
PK11195
An isoquinoline carboxamide that acts as a potent ligand for peripheral bezodiazepine receptor (Kd = 20nM). Exhibits anti-inflammatory properties. Binds to monocytes and following lesioning its binding up-regulated in brain macrophages and activated microglia. Shown to enhance the susceptibility of cells to apoptosis induction by DNA damaging agents and can reverse the suppression of apoptosis by Bcl-2. Serves as a ligand of the outer membrane translocator protein and reduces mitochondrial transmembrane potential within 30 minutes of exposure (100uM).CAS Number:85532-75-8. Group: Biochemicals. Grades: Highly Purified. CAS No. 85532-75-8. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences.
Worldwide
PK 11195
PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC50s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP 52028. CAS No. 85532-75-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19567.
PK 11195
Cell-permeable. A Selective peripheral benzodiazepine antagonist. Enhances apoptosis and induces mitochondria cytochrome c release. Inhibits insulin secretion induced by glucose. Also displays anticancer activity. Group: Biochemicals. Alternative Names: 1- (2-Chloro phenyl ) -N- methyl -N- (1- methyl propyl ) -3-isoquinolinecarboxamid e. Grades: Highly Purified. CAS No. 85532-75-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PK150
PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2165324-62-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133119.
PK 44 phosphate. Group: Biochemicals. Grades: Purified. CAS No. 1017682-66-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PK68
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2173556-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128348.
PK9327
PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations. Uses: Scientific research. Category: Signaling pathways. CAS No. 2413987-20-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145937.
PKA-IN-1
PKA-IN-1 is a potent and selective cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor with an IC50 of 0.03 μM. PKA-IN-1 inhibits cAK in a fashion that is competitive with respect to ATP as substrate[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 179985-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-115732.
PKA inhibitor fragment (6-22) amide
PKA inhibitor fragment (6-22) amide is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM) derived from the heat-stable PKA inhibitor protein PKI. It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Synonyms: PKI (6-22) amide; H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2; L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-seryl-glycyl-L-arginyl-L-threonyl-glycyl-L-arginyl-L-arginyl-L-asparagyl-L-alanyl-L-isoleucinamide; Tyadfiasgrtgrrnai-nh2; Protein Kinase A Inhibitor Fragment 6-22 amide. Grade: ≥95%. CAS No. 121932-06-7. Molecular formula: C80H130N28O24. Mole weight: 1868.08.
PKA Inhibitor Fragment (6-22) amide
PKA Inhibitor Fragment (6-22) amide is a highly potent and specific competitive inhibitor of PKA, with Ki values of 1.7 nM and 1.6 nM against human and bovine PKA catalytic subunits, respectively. The IC50 of PKA Inhibitor Fragment (6-22) amide targeting bovine PKA is 8.6 nM. PKA Inhibitor Fragment (6-22) amide effectively abolishes PKA activity in mouse brain and spinal cord, and exerts in vivo efficacy via intracerebroventricular administration. PKA Inhibitor Fragment (6-22) amide significantly reverses low-dose morphine analgesic tolerance in mice and blocks photoaffinity labeling of cAMP-dependent protein kinase. PKA Inhibitor Fragment (6-22) amide can be applied to research in fields related to the mechanism of morphine analgesic tolerance and skin wound healing[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PKI-(6-22)-amide. CAS No. 121932-06-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1290.
PKA inhibitor fragment (6-22) amide acetate
PKA Inhibitor Fragment (6-22) amide acetate is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM), derived from the heat-stable PKA inhibitor protein PKI. It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Synonyms: H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2.CH3CO2H; L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-seryl-glycyl-L-arginyl-L-threonyl-glycyl-L-arginyl-L-arginyl-L-asparagyl-L-alanyl-L-isoleucinamide acetic acid. Grade: ≥95%. Molecular formula: C82H134N28O26. Mole weight: 1928.11.
PKA Regulatory Subunit II Substrate
PKA Regulatory Subunit II Substrate (RII phosphopeptide) is a tool peptide derived from the regulatory subunit Type II (RII) of cyclic AMP-dependent protein kinase (PKA). PKA Regulatory Subunit II Substrate is commonly used to mimic the phosphorylation of protein kinases and as a specific substrate for protein phosphatases to assess the activities of these enzymes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RII phosphopeptide. CAS No. 103659-06-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10602.