A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Rasagiline Impurity 9. Uses: For analytical and research use. Alternative Names: (R)-N,N-di(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine. CAS No. 1458609-07-8. Molecular formula: C15H15N. Mole weight: 209.29. Catalog: APB1458609078.
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively[1]. Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-AGN1135 mesylate; TVP1012 mesylate. CAS No. 161735-79-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14605.
Rasagiline Mesylate
Rasagiline Mesylate is a selective irreversible MAO-B inhibitor. Category: Active pharmaceutical ingredients. CAS No. 161735-79-1. Product ID: API161735791. Molecular formula: C13H17NO3S. Mole weight: 267.34.
Rasagiline Mesylate
A selective irreversible MAO-B inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Rasagiline mesylate-[13C3]
Rasagiline mesylate-[13C3] is the labelled analogue of Rasagiline. Rasagiline is an irreversible inhibitor of monoamine oxidase-B. It can be used as a monotherapy to treat symptoms in early Parkinson's disease or as an adjunct therapy in more advanced cases. Synonyms: Rasagiline mesylate 13C3; (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine-13C3 Mesylate. Grade: 95% by HPLC; 95% atom 13C. CAS No. 1391052-18-8. Molecular formula: C10[13C]3H17NO3S. Mole weight: 270.32.
Rasagiline N- β-D-Glucuronide Methyl Ester
A protected metabolite of Rasagiline. Group: Biochemicals. Alternative Names: (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine N- β-D-Glucuronide Methyl Ester. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Rasagiline N- β-D-Glucuronide Sodium Salt
A metabolite of Rasagiline. Group: Biochemicals. Alternative Names: (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine N- β-D-Glucuronide Sodium Salt. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Rasagiline Tri-O-acetyl-N- β-D-glucuronide Methyl Ester. Group: Biochemicals. Alternative Names: (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine Tri-O-acetyl-N- β-D-glucuronide Methyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Rasburicase
Rasburicase is a recombinant form of urate oxidase that works by catalyzing the oxidation of uric acid to allantoin, which has a higher solubility. Rasburicase specifically degrades uric acid, rapidly lowers blood uric acid levels, and improves inflammation and kidney damage caused by uric acid crystal deposition. Rasburicase can effectively lower uric acid and prevent uric acid nephropathy, and is used in the study of severe hyperuricemia associated with tumor lysis syndrome (TLS) and refractory gout[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 134774-45-1. Pack Sizes: 1 mg. Product ID: HY-108844.
RaseglurantADX-10059
Raseglurant (ADX-10059) is an mGlu5 negative allosteric modulator. It effectively counters migraines and alleviates haloperidol-induced catalepsy in mice. Category: Active pharmaceutical ingredients. CAS No. 757950-09-7. Product ID: API757950097. Molecular formula: C15H13FN2. Mole weight: 240.28.
Rasfonin
Rasfonin is a fungal metabolite that has been found in Talaromyces sp. 3656-A1. It is a Ras-dependent apoptosis inducer that induces apoptosis in Ras-dependent cells such as Ba/F3-V12 cells. Synonyms: (-)-Rasfonin; (2E,4E,6S)-8-hydroxy-6-(hydroxymethyl)-4-methyl-2,4-octadienoic acid, (2R,3R)-3,6-dihydro-6-oxo-2-[(1S,3R,5E)-1,3,5-trimethyl-5-hepten-1-yl]-2H-pyran-3-yl ester. Grade: >95%. CAS No. 303156-68-5. Molecular formula: C25H38O6. Mole weight: 434.56.
RAS inhibitor Abd-7
RAS inhibitor Abd-7, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2351843-48-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122862.
Raspberry Extract
Raspberries contain significant amounts of polyphenol antioxidants such as anthocyanin pigments linked to potential health protection against several human diseases. The aggregate fruit structure contributes to its nutritional value, as it increases the proportion of dietary fiber, placing it among plant foods with the highest fiber contents known, up to 20% fiber per total weight. Raspberries are a rich source of vitamin C, with 30 mg per serving of 1 cup (about 50% daily value), manganese (about 60% daily value) and dietary fiber (30% daily value). Contents of B vitamins 1-3, folic acid, magnesium, copper and iron are considerable in raspberries. Raspberries rank near the top of all fruits for antioxidant strength, particularly due to their dense contents of ellagic acid (from ellagotannins), quercetin, gallic acid, anthocyanins, cyanidins, pelargonidins, catechins, kaempferol and salicylic acid. Yellow raspberries and others with pale-colored fruits are lower in anthocyanins. Group: Others. Purity: 40% Ellagic Acid Test by UV/HPLC. Raspberry Extract. Cat No: EXTC-198.
Raspberry Ketone
Raspberry Ketone. Alternative Names: 4-(4-Hydroxyphenyl)-2-butanone. CAS No. 5471-51-2. Product ID: CI-GU-0354. Alfa Chemistry - ISO 9001:32057 Certified.
Raspberry ketone synthetic. Group: Biochemicals. Alternative Names: 4-(4-Hydroxyphenyl)-2-butanone. Grades: Highly Purified. CAS No. 5471-51-2. Pack Sizes: 100g, 250g, 500g, 1kg, 2kg. Molecular Formula: C10H12O2. US Biological Life Sciences.
Worldwide
Raspberry Leaf Extract
Raspberry Leaf Extract. Applications: Preventing and curing the cardiovascular diseases heart disease , reducing the cholesterol in the blood preventing and curing the diabetes. suppress cancer cell grow effect to cure the colon cancer, cervical cancer, breast cancer and pancreas cancer. Group: Others. Synonyms: Raspberry Leaf Extract; Rubus idaeus. Purity: 5-10:1 By TLC. Appearance: Brown yellow fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Leaf. Species: Rubus idaeus. Raspberry Leaf Extract; Rubus idaeus; plant extract. Pack: 25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-175.
Raspberry Naturome Extract
Raspberry Naturome Extract. CAS No. 97676-33-0. Kosher: Y. VIGON Item # 503437. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Raspberry Powder
Raspberry powder is made from fresh raspberries (rubus idaeus l.). Raspberries are an important fruit that widely grown in all temperate regions of the world. Raspberry juice powder is a natural and clever way to introduce extra fruit into the diet, as well as being a natural, safe colouring and flavouring. Group: Others. Raspberry Powder; Rubus idaeus l. Cat No: EXTC-092.
Raspberry (Rubus Idaeus) Juice Powder
Raspberry (Rubus Idaeus) Juice Powder. Categories: sermorelin; 86168-78-7.
CA, FL & NJ
Ras-related protein Rab-27A (178-186)
A peptide fragment of Ras-related protein Rab-27A, which plays a role in cytotoxic granule exocytosis in lymphocytes. Synonyms: GTP-binding protein Ram (178-186).
Ras-related protein Rab-38 (50-58)
Ras-related protein Rab-38 (50-58) is a 9-aa peptide. Ras-related protein Rab-38 is involved in melanosomal transport and docking. And it plays an important role in the control of melanin production and melanosome biogenesis. Synonyms: Melanoma antigen NY-MEL-1 (50-58).
Rat CGRP-(8-37)
CGRP 8-37 (rat) is a peptide antagonist for CGRP1 receptors. Synonyms: Calcitonin Gene-Related Peptide 8-37 (rat); 8-37-a-Calcitoningene-related peptide (human reduced), 25-L-aspartic acid, 35-L-glutamic acid-; Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2; CGRP 8-37 rat; L-valyl-L-threonyl-L-histidyl-L-arginyl-L-leucyl-L-alanyl-glycyl-L-leucyl-L-leucyl-L-seryl-L-arginyl-L-seryl-glycyl-glycyl-L-valyl-L-valyl-L-lysyl-L-alpha-aspartyl-L-asparagyl-L-phenylalanyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-valyl-glycyl-L-seryl-L-alpha-glutamyl-L-alanyl-L-phenylalaninamide. Grade: ≥95%. CAS No. 129121-73-9. Molecular formula: C138H224N42O41. Mole weight: 3127.51.
Rat CGRP-(8-37)
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 129121-73-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P0209.
Rat IgG1 isotype control-InVivo
Rat IgG1 isotype control-InVivo monoclonal antibody (Clone:HRPN) reacts with horseradish peroxidase (HRP). Because HRP is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG1 antibodies in most in vivo and in vitro applications. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2119. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
United States; Europe
Rat IgG2a isotype control-InVivo
Rat IgG2a isotype control-InVivo can be used as an isotype-matched control for rat IgG2a antibodies. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2123. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
United States; Europe
Rat IgG2b isotype control-InVivo
Rat IgG2b isotype control-InVivo monoclonal antibody (Clone:LTF-2) reacts with keyhole limpet hemocyanin (KLH). Because KLH is not expressed by mammals this antibody is ideal for use as an isotype-matched control for rat IgG2b antibodies in most in vivo and in vitro applications. Group: Antibodies. Pack Sizes: 1mg. Product ID: A2116. Storage Conditions: Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.
United States; Europe
RatNP-4
Neutrophil antibiotic peptide NP-4 precursor is an antimicrobial peptide found in Rattus norvegicus (Rat), and has antibacterial, antiviral and antifungal activity. Synonyms: Np4; Neutrophil antibiotic peptide NP-4; Neutrophil alpha defensin 4. Grade: >85%. Molecular formula: C136H223N47O39S6. Mole weight: 3332.97.
Rattusin
Rattusin is an α-defensin-related peptide found in Rattus norvegicus, and is a highly potent antibiotic with broad-spectrum antibacterial activity. Grade: >98%.
Raubasine
Raubasine. Group: Biochemicals. Alternative Names: Ajmalicine. Grades: Highly Purified. CAS No. 483-04-5. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C21H24N2O3. US Biological Life Sciences.
Worldwide
raucaffricine β-glucosidase
Highly specific; some other ajmalan glucoside alkaloids are hydrolysed, but more slowly. Group: Enzymes. Synonyms: raucaffricine β-D-glucosidase; raucaffricine glucosidase. Enzyme Commission Number: EC 3.2.1.125. CAS No. 102925-37-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3808; raucaffricine β-glucosidase; EC 3.2.1.125; 102925-37-1; raucaffricine β-D-glucosidase; raucaffricine glucosidase. Cat No: EXWM-3808.
Rauvotetraphylline B
Rauvotetraphylline B is an alkaloid isolated from Rauvotetraphyllum. Synonyms: Rauvotetraphylline B; 1422506-50-0; (2S,3R,4S,5S,6R)-2-[[(1S,12S,14S,15E,16R)-13-(4,6-dimethylpyridin-2-yl)-15-ethylidene-3,17-diazapentacyclo[12.3.1.02,10.04,9.012,17]octadeca-2(10),4,6,8-tetraen-16-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol. Grade: >97%. CAS No. 1422506-50-0. Molecular formula: C31H37N3O6. Mole weight: 547.65.
Rauvovertine A
Rauvovertine A is an alkaloid isolated from the stems of Rauvolfia verticillata and exhibits anti-tumor activity. Synonyms: 17-epi-Rauvovertine A. Grade: 96.5%. CAS No. 2055073-75-9. Molecular formula: C19H22N2O3. Mole weight: 326.396.
Rauwolscine dot HCl is a standard α-2-adrenergic (AR) antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 6211-32-1. Pack Sizes: 100mg, 250mg. Molecular Formula: C21H27ClN2O3, Molecular Weight: 390.9. US Biological Life Sciences.
Worldwide
Rauwolscine hydrochloride
Rauwolscine hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 6211-32-1. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Ravoxertinib
Ravoxertinib (GDC-0994) is an orally active ERK kinase inhibitor with an IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0994. CAS No. 1453848-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15947.
Ravoxertinib (GDC-0994)
Ravoxertinib (GDC-0994) is a potent, orally available and highly selective ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. Phase 1. Group: Inhibitors. CAS No. 1453848-26-4. Pack Sizes: 5mg. Product ID: S7554. Formula: C21H18ClFN6O2. Smiles: CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)C(CO)C4=CC(=C(C=C4)Cl)F. Storage Conditions: 2 years -80 in solvent.
United States; Europe
Ravuconazole
Ergosterol biosynthesis inhibitor. Antifungal. Group: Biochemicals. Alternative Names: 4- [2- [ (1R, 2R) -2- (2, 4-Difluorophenyl) -2-hydroxy-1-methyl-3- (1H-1, 2, 4-triazol-1-yl) propyl] -4-thiazolyl] benzonitrile; [R-(R*,R*)]-. Grades: Highly Purified. CAS No. 182760-06-1. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Ravuconazole
Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-207147; ER-30346. CAS No. 182760-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14272.
Ravuconazole-d4
Ergosterol biosynthesis inhibitor. Antifungal. Group: Biochemicals. Alternative Names: 4-[2-[(1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile-d4; [R-(R*,R*)]-. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Ravulizumab
Ravulizumab (ALXN1210) is a humanized monoclonal antibody that specifically binds with high affinity to the human complement protein C5. Ravulizumab can be used for the research of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and myasthenia gravis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALXN1210. CAS No. 1803171-55-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99365.
Raw grapeseed oil
Raw grapeseed oil. Alternative Names: Traubenkernoel. CAS No. 8024-22-4. Purity: 0.98. Product ID: CI-EO-0065. Molecular formula: C18H32O2. Mole weight: 280.45 g/mol. IUPAC Name: (9Z,12Z)-octadeca-9,12-dienoic acid. Alfa Chemistry - ISO 9001:32057 Certified.
Raw Plasma Nanotubes Powder RN-020
Raw Plasma Nanotubes Powder RN-020. CAS No. 7440-44-0. Product ID: ACM7440440-80. Alfa Chemistry - ISO 9001:32057 Certified.
Raw Plasma Nanotubes Solution RN-020
Raw Plasma Nanotubes Solution RN-020. CAS No. 7440-44-0. Product ID: ACM7440440-206. Alfa Chemistry - ISO 9001:32057 Certified.
Raxatrigine
Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vixotrigine; GSK-1014802; CNV1014802. CAS No. 934240-30-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12796.
Raxatrigine hydrochloride
Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vixotrigine hydrochloride; GSK-1014802 hydrochloride; CNV1014802 hydrochloride. CAS No. 934240-31-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12796A.
Raxibacumab
Raxibacumab (ABthrax) is a human IgG1 monoclonal antibody against Bacillus anthracis protective antigen (PA). Raxibacumab blocks the toxins deleterious effects by preventing binding of the protective antigen component of the anthrax toxin to its receptors in host cells, thereby blocking the toxins deleterious effects. Raxibacumab can be used for anti-anthrax research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABthrax. CAS No. 565451-13-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9957.
Raxicept sodium impurity 1
Raxicept sodium impurity 1. Uses: For analytical and research use. Molecular formula: C18H18N2O10. Mole weight: 422.35. Catalog: APB11170.
Raxicept sodium impurity 2
Raxicept sodium impurity 2. Uses: For analytical and research use. Molecular formula: C18H16N2O9. Mole weight: 404.33. Catalog: APB11172.
Raxicept sodium impurity 3
Raxicept sodium impurity 3. Uses: For analytical and research use. Molecular formula: C20H20N6O9S. Mole weight: 520.47. Catalog: APB11173.
Raxicept sodium impurity 4
Raxicept sodium impurity 4. Uses: For analytical and research use. Molecular formula: C7H10N4O4S. Mole weight: 246.24. Catalog: APB11174.
Razoxane
Razoxane. Uses: For analytical and research use. CAS No. 21416-67-1. Mole weight: 268.27. EC Number: 244-379-2. Catalog: AP21416671.
Razuprotafib
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AKB-9778. CAS No. 1008510-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109041.
RB-3, a polycomb repressive complex 1 (PRC1) inhibitor, binds to RING1B-BMI1f, with a Kd of 2.8 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2396639-11-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139514.
RBC8
RBC8. Group: Biochemicals. Grades: Purified. CAS No. 361185-42-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
RBC8
RBC8 is a selective and allosteric RALA and RALB inhibitor. RBC8 stabilizes the inactive GDP-bound state of Ral, preventing its activation. RBC8 promotes the phosphorylation of proteins related to the MAPK/JNK pathway. RBC8 has the activity of inhibiting tumor cell proliferation, migration and invasion. RBC8 is used in the study of various cancers such as lung cancer, gastric cancer, and multiple myeloma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 361185-42-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12873.
R-Beta-Methyl-Phenylethylamine HCL Powder
R-Beta-Methyl-Phenylethylamine HCL Powder.
CA, FL & NJ
Rbin-2
Rbin-2 is a potent, reversible and selective inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family. Rbin-2 inhibits eukaryotic ribosome biogenesis and is a powerful probe for the eukaryotic ribosome assembly[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2032282-97-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100817.
RBN012759
RBN012759 is a potent, selective and orally active inhibitor of PARP14, with an IC50 of <3 nM. RBN012759 displays 300-fold selectivity over the monoPARPs and 1000-fold selectivity over the polyPARPs. RBN012759 decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2360851-29-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136979.
RBN012811 is a highly selective PROTAC-based PARP14 degrader. RBN012811 forms a ternary complex with cereblon by binding to the NAD+ site of PARP14, and mediates the specific degradation of PARP14 via the ubiquitin-proteasome pathway (IC50=10 nM). RBN012811 effectively depletes endogenous PARP14 in various cell lines and primary human macrophages, thereby downregulating IL-10 production and IFN-β mRNA levels, increasing phosphorylated STAT1 levels to enhance inflammatory signaling, and inhibiting interferon-induced ADPr condensate formation. RBN012811 also modulates viral replication, exhibiting increased HSV1 replication while reducing VSV replication. RBN012811 has important application value in research related to cancer and viral infections[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2569517-30-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173679.
RBN-2397
RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2381037-82-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136174.