A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Retinoic acid is an intermediate product of vitamin A metabolism. Gambogic acid is derived from the gamboge and is a protease activator and apoptosis inducer. This product is a pre-formulated composite liposome with retinoic acid and gambogic acid. It can induce apoptosis in tumor cells and exerts synergistic anti-tumor effects. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes.
Retinoic Acid-Glycyrrhizic Flavone Liposome
Retinoic acid is an intermediate product of vitamin A metabolism. Glycyrrhizic flavone are compounds extracted from licorice that have corticosteroid-like effects. This product is a pre-formulated composite liposome with retinoic acid and glycyrrhizic flavone. It can be used for epithelial cell abnormalities such as hyperpigmentation and photoaging. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes.
Retinoic Acid Liposome
Retinoic acid is an intermediate product of vitamin A metabolism, which can affect bone growth and promote metabolic effects such as epithelial cell proliferation, differentiation and keratolysis. This product is a pre-formulated liposome with vitamina acid. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes.
Retinoic Acid Related Compound 1
Retinoic Acid Related Compound 1 is an impurity of Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Synonyms: methyl (E)-3-methyl-4-oxobut-2-enoate; (E)-Methyl 3-methyl-4-oxobut-2-enoate; 3-Formylisocrotonic acid methyl ester; 153812-94-3; METHYL 3-METHYL-4-OXOBUT-2-ENOATE; 2-Butenoic acid, 3-methyl-4-oxo-, methyl ester; SCHEMBL4800118; DTXSID301019392; AMY39195; METHYL3-METHYL-4-OXOBUT-2-ENOATE; methyl (2E)-3-methyl-4-oxo-2-butenoate. CAS No. 40835-18-5. Molecular formula: C6H8O3. Mole weight: 128.13.
Retinoic Acid Related Compound 2
((2E,4E)-3-methyl-5-(2,6,6-trimethylcyclohex-1-en-1-yl)penta-2,4-dien-1-yl)triphenylphosphonium hydrogen sulfate is an impurity of Retinoic acid. Retinoic Acid is a metabolite of Vitamin A and ajusts its functions of cellular growth and differentiation. Molecular formula: C33H39PO4S. Mole weight: 562.70.
retinoid isomerohydrolase
This enzyme, which operates in the retinal pigment epithelium (RPE), catalyses the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle. Interaction of the enzyme with the membrane is critical for its enzymic activity. Group: Enzymes. Synonyms: all-trans-retinyl-palmitate hydrolase (ambiguous); retinol isomerase (ambiguous); all-trans-retinol isomerase:hydrolase (ambiguous); all-trans-retinylester 11-cis isomerohydrolase; RPE65 (gene name). Enzyme Commission Number: EC 3.1.1.64. CAS No. 106389-24-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3492; retinoid isomerohydrolase; EC 3.1.1.64; 106389-24-6; all-trans-retinyl-palmitate hydrolase (ambiguous); retinol isomerase (ambiguous); all-trans-retinol isomerase:hydrolase (ambiguous); all-trans-retinylester 11-cis isomerohydrolase; RPE65 (gene name). Cat No: EXWM-3492.
Retinol
Retinol is found in vitamin A, and is instrumental for stimulating new skin cells, which eventually contribute to younger looking skin. Pack Sizes: 1 kg. Product ID: CDC10-0559. Category: Anti-Acne Ingredients. Product Keywords: Cosmetic Ingredients; Active Ingredients; Anti-Acne Ingredients; Retinol; CDC10-0559.
Retinol
Fluorescence/Luminescence Spectroscopy. Uses: For analytical and research use. Group: Reagents. CAS No. 68-26-8. Pack Sizes: 250MG, 1G.
Retinol-d5
2H Labeled Compounds. Alternative Names: Vitamin A-d5;all-trans-Retinol-d5. CAS No. 1185244-58-9. Molecular formula: C20H25D5O. Mole weight: 291.48. Appearance: Light Yellow to Brown Thick Oil. Catalog: ACM1185244589.
Retinol impurity 1
Retinol impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 35031-06-2. Molecular Formula: C13H20O. Mole Weight: 192.3. Catalog: APB35031062.
Retinol impurity 11
Retinol impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 472-87-7. Molecular Formula: C20H26O. Mole Weight: 282.43. Catalog: APB472877.
Retinol impurity 12
Retinol impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 52340-45-1. Molecular Formula: C13H20O. Mole Weight: 192.3. Catalog: APB52340451.
Retinol impurity 13
Retinol impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 564-87-4. Molecular Formula: C20H28O. Mole Weight: 284.44. Catalog: APB564874.
Retinol impurity 2
Retinol impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 66879-87-6. Molecular Formula: C33H38P+. Mole Weight: 465.64. Catalog: APB66879876.
Retinol impurity 3
Retinol impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 79-76-5. Molecular Formula: C13H20O. Mole Weight: 192.3. Catalog: APB79765.
Retinol impurity 5
Retinol impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 22737-96-8. Molecular Formula: C20H30O. Mole Weight: 286.46. Catalog: APB22737968.
Retinol impurity 6
Retinol impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2052-63-3. Molecular Formula: C20H30O. Mole Weight: 286.46. Catalog: APB2052633.
Retinol impurity 7
Retinol impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1331640-07-3. Molecular Formula: C20H28O3. Mole Weight: 316.44. Catalog: APB1331640073.
Retinol impurity 8
Retinol impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 22737-97-9. Molecular Formula: C20H30O. Mole Weight: 286.46. Catalog: APB22737979.
Retinol impurity 9
Retinol impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 4159-20-0. Molecular Formula: C20H26O2. Mole Weight: 298.43. Catalog: APB4159200.
retinol O-fatty-acyltransferase
Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA. Group: Enzymes. Synonyms: retinol acyltransferase; retinol fatty-acyltransferase. Enzyme Commission Number: EC 2.3.1.76. CAS No. 81295-48-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2256; retinol O-fatty-acyltransferase; EC 2.3.1.76; 81295-48-9; retinol acyltransferase; retinol fatty-acyltransferase. Cat No: EXWM-2256.
Retinol palmitate
It can transdermally absorb, resist keratinization, stimulate the growth of collagen and elastin, and increase the thickness of epidermis and dermis. Enhances skin elasticity, effectively eliminates wrinkles, promotes skin renewal, maintains skin vitality. Group: Material of cosmetics. Alternative Names: Vitamin A palmitate, all-trans-Retinol palmitate. CAS No. 79-81-2. Molecular formula: C36H60O2. Mole weight: 524.86. Catalog: ACM79812.
Retinyl acetate
Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Retinol acetate; Vitamin A acetate. CAS No. 127-47-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-N0679.
Retinyl glucoside
Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals. Synonyms: Retinyl β-D-glucoside. Grades: >98%. CAS No. 136778-12-6. Molecular formula: C26H40O6. Mole weight: 448.59.
Retinyl palmitate
Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations. Uses: Scientific research. Group: Natural products. Alternative Names: Vitamin A palmitate; Retinol palmitate. CAS No. 79-81-2. Pack Sizes: 100 mg. Product ID: HY-B1384.
Retinyl Retinoate
Retinyl Retinoate. Group: Biochemicals. Alternative Names: Retinoic Acid Retin-15-yl Ester; Retinoic Acid Ester with Retinol. Grades: Highly Purified. CAS No. 15498-86-9. Pack Sizes: 10mg, 25mg. US Biological Life Sciences.
Worldwide
Retinyl (Vitamin A) Palmitate
Vitamin A palmitate is a more stable, synthetic version of the essential nutrient vitamin A joined to palmitic acid. Synonyms: Pantothenate, Vitamin B5. Grades: >98%. CAS No. 79-81-2. Molecular formula: C36H60O2. Mole weight: 524.86.
RET Kinase Inhibitor 1
RET Kinase Inhibitor 1 is a gut-restricted inhibitor of RET kinase. It is under development for the treatment of irritable bowel syndrome. Synonyms: GSK3179106; 2-[4-(4-ethoxy-6-oxo-1H-pyridin-3-yl)-2-fluorophenyl]-N-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]acetamide. CAS No. 1627856-64-7. Molecular formula: C22H21F4N3O4. Mole weight: 467.4.
R-(+)-Etomoxir
R-(+)-Etomoxir. Group: Biochemicals. Alternative Names: (R) -2- [6- (4-Chlorophenoxy) hexyl] oxiranecarboxylic acid, ethyl ester. Grades: Highly Purified. CAS No. 124083-20-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H23ClO4. US Biological Life Sciences.
An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug. Group: Biochemicals. Alternative Names: (R) -2- [6- (4-Chlorophenoxy) hexyl] oxiranecarboxylic Acid, Ethyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Retorphan
Retorphan. Group: Biochemicals. Alternative Names: N-[(2R)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine Phenylmethyl Ester; Dexecadotril. Grades: Highly Purified. CAS No. 112573-72-5. Pack Sizes: 5mg. Molecular Formula: C21H23NO4S, Molecular Weight: 385.48. US Biological Life Sciences.
Worldwide
Retorphan-d5
Retorphan-d5. Group: Biochemicals. Alternative Names: N-[(2R)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine Phenylmethyl Ester-d5; Dexecadotril-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C21H18NO4S, Molecular Weight: 385.48. US Biological Life Sciences.
Worldwide
Retosiban
Retosiban is a oxytocin receptor antagonist. It was developed by GlaxoSmithKline for the treatment of preterm labour. Retosiban has high affinity for the oxytocin receptor with Ki value of 0.65 nM. It has greater than 1400-fold selectivity over the related vasopressin receptors. Uses: Preterm labour. Synonyms: GSK221149A; GSK 221149A; GSK-221149A; GSK221149; GSK 221149; GSK-221149; GSK221,149; GSK 221,149; GSK-221,149; Retosiban; (3R,6R)-6-((2S)-Butan-2-yl)-3-(2,3-dihydro-1H-inden-2-yl)-1-((1R)-1-(2-methyl- 1,3-oxazol-4-yl)-2-(morpholin-4-yl)-2-oxoethyl)piperazine-2,5-dione. Grades: 98%. CAS No. 820957-38-8. Molecular formula: C27H34N4O5. Mole weight: 494.59.
Retosiban
Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a K i of 0.65 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK 221149; GSK 221149A. CAS No. 820957-38-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14778.
RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1036069-26-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108636.
RETRA hydrochloride
RETRA hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1173023-52-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
RETRA hydrochloride
RETRA hydrochloride, an antitumor agent, inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Synonyms: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride. Grades: ≥99% by HPLC. CAS No. 1173023-52-3. Molecular formula: C11N11NO3S2.HCl. Mole weight: 305.8.
Retreversine
Reversine is a 2,6-disubstituted purine derivative used for stem cell differentiation. It also has the role as a potent inhibitor of the mitotic kinase Mps1. Synonyms: N2-Cyclohexyl-N6-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine. Grades: ≥98%. CAS No. 1028332-91-3. Molecular formula: C21H27N7O. Mole weight: 393.5.
Retro-2
Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network. It has been shown to be effective against a range of bacterial and virus pathogens, both in vitro and in animal models. Synonyms: RN 1-001; 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone. Grades: ≥98%. CAS No. 1429192-00-6. Molecular formula: C19H16N2OS. Mole weight: 320.4.
Retro-2
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC 50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1201652-50-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122571.
Retrobradykinin
Retrobradykinin, a bradykinin analog nonapeptide, shows no significant kinin activity. Synonyms: RFPSFGPPR. CAS No. 5991-13-9. Molecular formula: C50H73N15O11. Mole weight: 1060.22.
Retrochalcone
Retrochalcone. Group: Biochemicals. CAS No. 34221-41-5. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Retrocyclin-1
Retrocyclin-1, a theta-defensin, is a circular octadecapeptide containing an internal trisulfide ladder. In addition to its antimicrobial activity, it has a significant in vitro ability to protect human cells from infection with the T- and M-tropic strains of HIV-1. Retrocyclin is a small molecule HIV-1 entry inhibitor. Synonyms: RC-100; Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg) (Disulfide bridge: Cys3-Cys16, Cys5-Cys14, Cys7-Cys12); cyclo[L-arginyl-L-cysteinyl-L-isoleucyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-isoleucyl-L-cysteinyl-L-arginyl-L-cysteinyl-L-isoleucyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-isoleucyl-L-cysteinyl] (2->11),(4->9),(13->18)-tris(disulfide). Grades: ≥95%. CAS No. 724760-19-4. Molecular formula: C74H128N30O18S6. Mole weight: 1918.39.
Retrocyclin-2
Retrocyclin-2 is a synthetic antimicrobial peptide. It has activity against viruses. Synonyms: 1-[3-[tetrakis(3-guanidinopropyl)-tetrakis[(1S)-1-methylpropyl]-octadecaoxo-[?]yl]propyl]guanidine. Molecular formula: C78H137N33O18S6. Mole weight: 2017.5.
Retrocyclin-3
Retrocyclin-3 is a synthetic antimicrobial peptide. It has activity against viruses. Synonyms: 1-[3-[pentakis(3-guanidinopropyl)-tetrakis[(1S)-1-methylpropyl]-octadecaoxo-[?]yl]propyl]guanidine. Molecular formula: C82H146N36O18S6. Mole weight: 2116.7.
retro-Methyl-α-ionol
An intermediate for synthesizing β-Damascenone. Group: Biochemicals. Alternative Names: (6Z). Grades: Highly Purified. CAS No. 945426-65-3. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Retrorsine N-oxide
Retrorsine N-oxide is a genotoxic agent that has been shown to cause liver lesions and skin cancer in the rat liver microsomes. It is also capable of causing liver damage in humans when used for long periods of time. Retrorsine N-oxide is an oxidized form of retrorsine, which is a natural toxin found in the plant Dichapetalum cymosum. The increased toxicity may be due to the presence of hydroxyl groups, which are more reactive than hydrogen atoms, or due to its ability to induce matrix effects. Retrorsine N-oxide has been shown to have carcinogenic potential in animals, with the most severe effects occurring after chronic exposure. It has also been shown to be genotoxic in cultured human liver cells. Group: Other alkaloids. CAS No. 15503-86-3. Molecular formula: C18H25NO7. Mole weight: 367.39 g/mol. Canonical SMILES: C/C=C\1/C[C@H] ([C@@] (C (=O)OCC2=CC[N+]3 ([C@H]2[C@@H] (CC3)OC1=O)[O-]) (CO)O)C. Catalog: ACM15503863.
retroviral ribonuclease H
Comments: Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication. To perform this task the enzyme combines two distinct activities. The polymerase domain (EC 2.7.7.49, RNA-directed DNA polymerase) occupies the N-terminal two-thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third. The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites. Group: Enzymes. Synonyms: RT/RNase H; retroviral reverse transcriptase RNaseH; HIV RNase H. Enzyme Commission Number: EC 3.1.26.13. CAS No. 9050-76-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3589; retroviral ribonuclease H; EC 3.1.26.13; 9050-76-4; RT/RNase H; retroviral reverse transcriptase RNaseH; HIV RNase H. Cat No: EXWM-3589.
It is originally isolated from Act. sp. Reumycin is toxic to Airy carcinoma, sarcoma-180, sarcoma-37, lymphosarcoma and other tumor cells. Synonyms: Reumitsin; Rheumygin; 1-demethyltoxoflavin; NSC 99733; 6-Methylpyrimido(5,4-e)-as-triazine-5,7(1H,6H)-dione. CAS No. 5016-18-2. Molecular formula: C6H5N5O2. Mole weight: 179.14.
Reutericyclin
Reutericyclin (Reutericycline), a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. Reutericyclin (Reutericycline) exhibits a broad inhibitory spectrum including Lactobacillus spp. , Bacillus subtilis , B. cereus , Enterococcus faecalis , Staphylococcus aureus , and Listeria innocua [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Reutericycline. CAS No. 303957-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103249.
REV 5901
REV 5901 is an antagonist of CysLT1 receptor with Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with IC50 value of 0.12 μM. Uses: Platelet aggregation inhibitors. Synonyms: REV-5901; REV5901; 1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol. Grades: ≥98%. CAS No. 101910-24-1. Molecular formula: C22H25NO2. Mole weight: 335.4.
Revaprazan HCl
Revaprazan is an acid pump antagonist. It can reduce gastric acid secretion which is used for the treatment of gastritis. Synonyms: 4-(3,4-Dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-2-pyrimidinamine Hydrochloride; 5,6-Dimethyl-2-(4-fluorophenylamino)-4-(1-methyl- 1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride; Revaprazan Hydrochloride; SB 641257 Hydrochloride; SB 641257A; YH 1885. Grades: > 95%. CAS No. 178307-42-1. Molecular formula: C22H23N4F·HCl. Mole weight: 398.9041632.
Revaprazan hydrochloride
Revaprazan hydrochloride. Group: Biochemicals. Alternative Names: 4-(3,4-Dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-2-pyrimidinamine hydrochloride; 5,6-Dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride; Revaprazan hydrochloride. Grades: Highly Purified. CAS No. 178307-42-1. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C22H24ClFN4. US Biological Life Sciences.
Worldwide
Revaprazan hydrochloride
Revaprazan hydrochloride is a novel acid pump antagonist ( APA ). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 178307-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7067.
Revaprazan Impurity A
An impurity of Revaprazan. Revaprazan is an acid pump antagonist. It can reduce gastric acid secretion which is used for the treatment of gastritis. Grades: > 95%. Molecular formula: C14H17FN4. Mole weight: 260.32.
Revefenacin
Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a K i of 0.18 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TD-4208; GSK1160724. CAS No. 864750-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15851.
Revefenacin
Revefenacin, also knownc as TD-4208 and GSK1160724, is potent and selective muscarinic receptor antagonist in development for the treatment of COPD. Synonyms: TD-4208; TD4208; TD 4208; GSK1160724; GSK-1160724; GSK 1160724. Grades: 98%. CAS No. 864750-70-9. Molecular formula: C35H43N5O4. Mole weight: 597.76.
Revefenacin Impurity 3
Revefenacin Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(([1,1'-biphenyl]-2-ylcarbamoyl)oxy)-1-(2-(4-((4-carbamoylpiperidin-1-yl)methyl)-N-methylbenzamido)ethyl)piperidine 1-oxide. Molecular Formula: C35H43N5O5. Mole Weight: 613.75. Catalog: APB02188.
Revefenacin Impurity 9
Revefenacin Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1- (4- ( (2- (4-hydroxypiperidin-1-yl)ethyl) (methyl)carbamoyl)benzyl)piperidine-4-carboxamide. Molecular Formula: C22H34N4O3. Mole Weight: 402.53. Catalog: APB02187.
REV-ERB Agonist II, SR9009
A pyrrolidinecarbamate compound that acts as a specific REV-ERB-alpha/beta agonist. Exhibits a direct and reversible binding (Kd = 800nM REV-ERB-alpha) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800nM in Gal4-REV-ERB-alpha and beta transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern. 217739, CAS # 1379686-30-2, acts as a specific REV-ERB-α/ β agonist that exhibits a direct and reversible binding (Kd = 800nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1379686-30-2. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences.
Worldwide
Reveromycin A
Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of epidermal growth factor (EGF). It is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behavior against human cell lines KB and K562 as well as potent antifungal activity. More recently it has been shown to inducing apoptosis in osteoclasts thus inhibiting bone resorption. Group: Biochemicals. Grades: Highly Purified. CAS No. 134615-37-5. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
Reveromycin A
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces , is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 134615-37-5. Pack Sizes: 1 mg. Product ID: HY-129337.
Reveromycin A
The dominant analogue of complex of spiroketals isolated from streptomyces sp. It is an inhibitor of the mitogenic activity of EGF and a G1 phase cell cycle inhibitor. It selectively inhibits isoleucyl-trna synthetase. It has anti-proliferation effect on human cell lines KB and K562, and has potent antifungal activity. Synonyms: (-)-Reveromycin A; [2S-[2α(1E, 3E), 3β, 6α[8S*(2E, 4E, 6R*, 7R*, 8E), 9R*]]]-butanedioic acid mono[3-butyl-8-(9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrienyl)-2-(4-carboxy-3-methyl-1,3-butadienyl)-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] Ester; Butanedioic Acid Mono[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrienyl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadienyl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] Ester. Grades: >99% by HPLC. CAS No. 134615-37-5. Molecular formula: C36H52O11. Mole weight: 660.79.
Reveromycin B
Reveromycin B is a polyketide antibiotic isolated from Streptomyces, which can inhibit mitotic activity. Synonyms: BDBM50217842; ZINC49871994. Grades: >98% by HPLC. CAS No. 144860-68-4. Molecular formula: C36H52O11. Mole weight: 660.79.
Reveromycin B
Reveromycin B is an much less active analogue of reveromycin A formed by rearrangement of the 6to6 spiroketal to a 5to6 spiroketal. Lacking much of the biological activity of reveromycin A, the reveromycin B is a useful negative control in resolving the mode of action of this class. Group: Biochemicals. Grades: Highly Purified. CAS No. 144860-68-4. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
Reveromycin C
Reveromycin C is a minor analogue of the reveromycin complex isolated from a Streptomyces sp. Published information suggests that reveromycin C exhibits comparable potency to reveromycin A, its butyl homologue. In Microbial Screening Technologies in-house screens Reveromycins C and A had similar biological profiles but Reveromycin C was generally more potent. Group: Biochemicals. Grades: Highly Purified. CAS No. 144860-69-5. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
Reveromycin C
Reveromycin C is a polyketide isolated from Streptomyces. It is an antibiotic inhibitor with mitotic activity that responds to EGF. Grades: >95% by HPLC. CAS No. 144860-69-5. Molecular formula: C37H54O11. Mole weight: 674.82.