A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
TiVAlCrZr High-Entropy Alloy Spherical Powder is composed of Ti, V, Al, Cr, Zr. Alfa Chemistry offers high-quality High-Entropy Alloy with competitive pricing.
Tivantinib
Tivantinib is a highly selective c-Met tyrosine kinase inhibitor with a Ki of 355 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARQ 197; (3R,4R)-ARQ 198. CAS No. 905854-02-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50686.
TiVC MXene
TiVC MXene. Purity: 0.99.
Tividenofusp alfa
Tividenofusp alfa (DNL - 310) is a modified iduronate - 2 - sulfatase fusion protein capable of crossing the blood-brain barrier. Tividenofusp alfa can be used in research on mucopolysaccharidosis type II[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DNL-310. CAS No. 2641020-57-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990724.
Tivozanib
Tivozanib (AV-951; KRN951) is a selective, orally active inhibitor for vascular endothelial growth factor receptor (VEGFR)-1, 2 3, with IC50s of 30, 6.5 and 15 nM, respectively. Tivozanib exhibits antitumor efficacy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AV-951; KRN951. CAS No. 475108-18-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10977.
Tivumecirnon
Tivumecirnon (FLX475) is an orally active, selective CCR4 antagonist. Tivumecirnon blocks the binding of CCR4 to its ligands, CCL17 and CCL22, thereby reducing Treg infiltration into the tumor microenvironment. Tivumecirnon has antitumor activity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FLX475. CAS No. 2174938-78-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148494.
Tixagevimab
Tixagevimab (AZD8895) is a human monoclonal antibody that targets the SARS-CoV-2 receptor binding domain (RBD). It exhibits neutralizing activity against SARS-CoV-2 by binding to the RBD and the S-glycoprotein ectodomain and blocking S-glycoprotein-mediated binding to the receptor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD8895; COV2-2196. CAS No. 2420564-02-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99556.
Tixosil
Tixosil.
Tizanidine
Tizanidine, a skeletal muscle relaxant, is an orally effective central α2-adrenoceptor agonist (IC50 = 6.9 nmol). Tizanidine primarily exerts muscle relaxation effects by inhibiting the release of excitatory amino acids (glutamate and aspartate) from the presynaptic terminals of spinal cord interneurons. Tizanidine has anti-injury activity and can inhibit gastrointestinal (GI) transport. Tizanidine can inhibit the proliferation, migration, and invasion of lung cancer cells and induce cell apoptosis by upregulating Nischarin and inhibiting the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine can be used to treat spasticity caused by diseases such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51322-75-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194.
Tizanidine
Tizanidine. Alternative Names: 3-Benzothiadiazole-4-amine,5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-1. CAS No. 51322-75-9. Purity: 98%. Product ID: ACM51322759-1. Molecular formula: C9H8ClN5S. Mole weight: 253.71. IUPAC Name: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine. Canonical SMILES: C1CN=C(N1)NC2=C(C=CC3=NSN=C32)Cl. Alfa Chemistry - ISO 9001:32057 Certified.
Tizanidine-d4
Labeled Tizanidine, a muscle relaxant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Tizanidine-[d4]
Tizanidine-[d4] is the labelled analogue of Tizanidine. Tizanidine is an α2 adrenergic agonist used as a muscle relaxant. Synonyms: Tizanidine D4; 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl-d4)-2,1,3-benzothiadiazol-4-amine. Grade: 100% HPLC; 99% atom D. CAS No. 1188331-19-2. Molecular formula: C9H4DClN5S. Mole weight: 257.74.
Tizanidine-[d4] Hydrochloride
Tizanidine-[d4] Hydrochloride is the labelled analogue of Tizanidine, which has been found to be an α2-adrenergic agonist and could be used as a muscle as well as skeletal relaxant. Synonyms: Tizanidine-d4 Hydrochloride; 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl-d4)-2,1,3-benzothiadiazol-4-amine Hydrochloride. Grade: 95% by HPLC; 95% atom D. CAS No. 1188263-51-5. Molecular formula: C9H5D4Cl2N5S. Mole weight: 294.20.
Tizanidine EP Impurity A
Tizanidine EP Impurity A. Uses: For analytical and research use. CAS No. 51322-69-1. Molecular formula: C9H9N5S. Mole weight: 219.27. Catalog: APB51322691.
Tizanidine EP Impurity B
Tizanidine EP Impurity B. Uses: For analytical and research use. CAS No. 51323-05-8. Molecular formula: C7H5ClN4S2. Mole weight: 244.72. Catalog: APB51323058.
Tizanidine EP Impurity C
Tizanidine EP Impurity C. Uses: For analytical and research use. CAS No. 1147548-83-1. Molecular formula: C16H14Cl2N10S2. Mole weight: 481.38. Catalog: APB1147548831.
Tizanidine EP Impurity D
Tizanidine EP Impurity D. Uses: For analytical and research use. CAS No. 560120-68-5. Molecular formula: C8H7ClN4S2. Mole weight: 258.74. Catalog: APB560120685.
Tizanidine EP Impurity D Hydriodide Salt
Tizanidine EP Impurity D Hydriodide Salt. Uses: For analytical and research use. CAS No. 51323-03-6. Molecular formula: C8H8ClIN4S2. Mole weight: 386.65. Catalog: APB51323036.
Tizanidine EP Impurity E
Tizanidine EP Impurity E. Uses: For analytical and research use. CAS No. 30536-19-7. Molecular formula: C6H4ClN3S. Mole weight: 185.63. Catalog: APB30536197.
Tizanidine EP Impurity F
Tizanidine EP Impurity F. Uses: For analytical and research use. CAS No. 1147548-85-3. Molecular formula: C16H11Cl2N9S2. Mole weight: 464.35. Catalog: APB1147548853.
Tizanidine EP Impurity G
Tizanidine EP Impurity G. Uses: For analytical and research use. CAS No. 51322-80-6. Molecular formula: C7H3ClN4S. Mole weight: 210.64. Catalog: APB51322806.
Tizanidine hydrochloride
Tizanidine hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Tizanidine hydrochloride
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C9H8N5ClS ¢HCl. CAS No. 64461-82-1. Prepack ID 71395830-5g. Molecular Weight 290.17. See USA prepack pricing.
Tizanidine Hydrochloride
Tizanidine hydrochloride is a centrally acting alpha-2 adrenergic agonist used as a short-acting muscle relaxant for spasticity management. The drug is chemically an imidazole derivative unrelated to other muscle relaxants. Applications: Tizanidine is indicated for the management of spasticity associated with multiple sclerosis, spinal cord injury, cerebral palsy, and stroke. it is also used off-label for chronic tension-type headaches and myofascial pain syndromes. Category: Active pharmaceutical ingredients. Synonyms: Tizanidine Hcl; DS 103-282; AN021; DS-103-282; B53E3NMY5C; Tizanidine (as hydrochloride); ONTRALFY. CAS No. 64461-82-1. Product ID: API0231623. Molecular formula: C9H9Cl2N5S. Mole weight: 290.17. EINECS: 630-412-1. InChIKey: ZWUKMNZJRDGCTQ-UHFFFAOYSA-N. Appearance: White to off-white fine crystalline powder.
Tizanidine, Hydrochloride
An α2-adrenergic agonist; centrally active myotonolytic. A muscle relaxant (skeletal). Group: Biochemicals. Grades: Highly Purified. CAS No. 64461-82-1. Pack Sizes: 10mg, 50mg, 100mg, 250mg. Molecular Formula: C?H?Cl?N?S. US Biological Life Sciences.
Worldwide
Tizanidine Impurity 1
Tizanidine Impurity 1. Uses: For analytical and research use. CAS No. 22308-12-9. Molecular formula: C19H24O6S2. Mole weight: 412.52. Catalog: APB22308129.
Tizanidine Related Compound A
Tizanidine Related Compound A. Uses: For analytical and research use. CAS No. 30536-19-7. Mole weight: 185.63. Catalog: AP30536197.
Tizanidine Related Compound B
Tizanidine Related Compound B. Uses: For analytical and research use. CAS No. 173532-15-5. Mole weight: 295.75. Catalog: AP173532155.
Tizanidine Related Compound C
Tizanidine Related Compound C. Uses: For analytical and research use. CAS No. 5391-52-6. Mole weight: 144.19. Catalog: AP5391526.
Tizanidine USP Related Compound B
Tizanidine USP Related Compound B. Uses: For analytical and research use. CAS No. 173532-15-5. Molecular formula: C11H10ClN5OS. Mole weight: 295.75. Catalog: APB173532155.
Tizanidine USP Related Compound C
Tizanidine USP Related Compound C. Uses: For analytical and research use. CAS No. 5391-52-6. Molecular formula: C5H8N2OS. Mole weight: 144.19. Catalog: APB5391526.
Tizaterkib
Tizaterkib (AZD0364) is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1, compound example 18, has an IC50 of 0.6 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD0364. CAS No. 2097416-76-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111483.
Tizoxanide
A metabolite of Nitazoxonide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Tizoxanide
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells[1][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TIZ. CAS No. 173903-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12687.
Tizoxanide-[d4]
Tizoxanide-[d4] is the labelled analogue of Tizoxanide. Tizoxanide is the active metabolite of nitazoxanide, an anti-infective that has been approved for the treatment of diarrhea caused by Giardia lamblia or Crytosporidium parvum. Tizoxanide is active against anaerobic bacteria, protozoan parasites, and viruses. Synonyms: Tizoxanide D4; 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide-d4. Grade: 95% by HPLC; 98% atom D. CAS No. 1246817-56-0. Molecular formula: C10H3D4N3O4S. Mole weight: 269.27.
TiZrVTa High-Entropy Alloy
Unlike most current alloy materials, high-entropy alloys are alloy materials that contain equimolar or approximately equimolar elements. TiZrVTa High-Entropy Alloy is composed of Ti, Zr, V, and Ta.
TJ-M2010-5
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway[1][2]. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1357471-57-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139397.
TK-129
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3031476-73-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151483.
TK216
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1903783-48-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122903.
TL02-59
TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC50s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1315330-17-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112852.
TL033
TL033 is a drug-Linker conjugates for ADC. TL033 contains a linker and bioactive small molecule toxins. TL033 can conjugate with Sacituzumab antibody (anti Trop-2) for synthesizing BT001021. BT001021 has anti-cancer activities against various cancers, such as breast cancer, non-small cell lung cancer (NSCLC), gastric cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tirumotecan. CAS No. 2356230-22-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-147340.
TL033 TFA
TL033 TFA is a drug-Linker conjugates for ADC. TL033 TFA contains a linker and bioactive small molecule toxins. TL033 TFA can conjugate with Sacituzumab antibody (anti Trop-2) for synthesizing BT001021. BT001021 has anti-cancer activities against various cancers, such as breast cancer, non-small cell lung cancer (NSCLC), gastric cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tirumotecan TFA. CAS No. 2746343-70-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147340A.
TL-119
TL-119 is an antibiotic isolated from Bacillus subtilis. It is effective against gram-positive bacteria and fungi. Synonyms: Antibiotic TL-119; TL 119. CAS No. 55599-68-3. Molecular formula: C42H57N7O9. Mole weight: 803.9.
TL12-186
TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC50=73 nM) and CDK9/cyclin T1 (IC50=55 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250025-88-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130665.
TL13-112
TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib?(HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2229037-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123919.
TL13-12
TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 (HY-10192) and the Cereblon ligand of Pomalidomide (HY-10984)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2229037-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122582.
TL4-12
TL4-12 is a selective MAP4K2/GCK inhibitor, dose-dependently downregulates IKZF1 and BCL-6 and leads to MM cell proliferation inhibition (IC50=37 nM) accompanied by induction of apoptosis. TL4-12 can be used to overcome immunomodulatory agent resistance in multiple myeloma (MM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620820-12-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-123714.
TL8-506
TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1268163-15-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-20457.
TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1-1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TER117. CAS No. 152684-53-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-13634B.
TLQP 21
TLQP 21 is a VGF-derived peptide. TLQP 21 has been shown to protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis. TLQP 21 has the potential for the prevention of early phase diet-induced diabetes. Synonyms: TLQP 21; TLQP21; TLQP-21. Grade: ≥95%. CAS No. 869988-94-3. Molecular formula: C107H170N40O26. Mole weight: 2432.7.
TLQP 21
TLQP 21. Group: Biochemicals. Grades: Purified. CAS No. 869988-94-3. Pack Sizes: 1mg. US Biological Life Sciences.
A cell-permeable benzotropolone compound that competes against Pam3CSK4- for TLR1/TLR2 heterodimer binding (Ki = 410nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580nM) without apparent cytotoxicity (up to 100uM and 24h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5uM and little inhibitory potency against a panel of 10 kinases at 5uM (by <11% inhibition). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??O?. US Biological Life Sciences.
Worldwide
TLR2-IN-C29
TLR2-IN-C29 (C29) is a Toll-like receptor 2 (TLR2) inhibitor that inhibits TLR2/1 and TLR2/6 signaling. Group: Inhibitors. Alternative Names: C29. CAS No. 363600-92-4. Pack Sizes: 5mg. Product ID: S6597. Formula: C16H15NO4. Smiles: CC1=C(C=CC=C1N=CC2=C(C(=CC=C2)OC)O)C(=O)O. Storage Conditions: 3 years -20°C powder.
United States; Europe
TLR3, Control Peptide (Toll Like Receptor 3)
TLR3, Control Peptide (Toll Like Receptor 3). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 100ug. US Biological Life Sciences.
A thiophene carboxamidopropionate compound that acts as a direct, competitive and high affinity inhibitor of dsRNA binding to TLR3 (Ki=2.96uM; =19nM for dsRNA binding to TLR3) and selectively antagonizes stimulated TLR3 signaling without affecting TLR1/2, TLR2/6, TLR4 and TLR7 pathways. Shown to efficiently repress TNF-a and IL-1b (IC90=27uM) and NO production (IC50=3.44uM) in Poly(I:C)-induced RAW 264.7 macrophages. Exhibits minimal cytotoxicity (IC50>100uM in RAW 264.7 cells) and is weakly active against a panel of 12-representative kinases and 4-cytochrome enzymes (in vitro assays). Group: Biochemicals. Alternative Names: (R) -2- (3-Chloro-6-fluorobenzo [b]thiophene-2-carboxamido) -3-phenylpropanoic Acid; CU CPT 4a. Grades: Highly Purified. CAS No. 1279713-77-7. Pack Sizes: 10mg. Molecular Formula: C18H13ClFNO3S, Molecular Weight: 377.8. US Biological Life Sciences.
TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 40592-88-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107575.