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| Product | Description | |
|---|---|---|
| TLR4-IN-C34-C2-COOH | TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34-C2-COOH can be used in the research of inflammation and acute myocardial injury. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1159408-54-4. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-W092043. |  |
| TLR4 Inhibitor, TAK-242 (Ethyl- (6R) -6- (N- (2-chloro-4-fluorophenyl) sulfamoyl) cyclohex-1-ene-1-carboxylate) | A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 243984-11-4. Pack Sizes: 5mg. Molecular Formula: C??H??ClFNO?S, Primary Target: TLR4. US Biological Life Sciences. |  Worldwide |
| TLR7/8 agonist 1 | TLR7/8 agonist 1 is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. Uses: Scientific research. Category: Signaling pathways. CAS No. 1258457-59-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103698. | |
| TLR7/8 agonist 3 | TLR7/8 agonist 3 (Compound II) is a potent TLR7 and TLR8 agonist, extracted from patent WO2016057618 (compound of formula (II))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 642473-95-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130797. | |
| TLR7/8 agonist 4 | TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2388520-33-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-139017. | |
| TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride | TLR7/8 agonist 4 hydroxy-PEG10-acid hydrochloride (compound 9) is a drug-linker conjugates for ADC with potent antitumor activity by using TLR7/8 agonist 4 (HY-139018; a TLR7/8 agonist), linked via the non-cleavable ADC linker hydroxy-PEG10-acid (HY-133307)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2388520-36-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139018A. | |
| TLR7/8 agonist 6 | TLR7/8 agonist 6 is a TLR7/8 agonist with EC50s of 0.18 μM and 5.34 μM in TLR7 or TLR8 HEK-SEAP reporter cells, respectively. TLR7/8 agonist 6 potently stimulates production of TNFα, IFNγ, and IL-1β. TLR7/8 agonist 6 can be used for research on cancer and infectious diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2115702-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145885. | |
| TLR7/8 agonist 8 | TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2649170-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153543. | |
| TLR7/8-IN-1 | TLR7/8-IN-1 is a crystalline from of a TLR7/TLR8 inhibitor extracted from patent WO2019220390, compound 2b. TLR7/8-IN-1 can be used for the research of autoimmune disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2205095-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139323. | |
| TLR7 agonist 1 | TLR7 agonist 1 is a selective TLR7 agonist with an LEC value of 90 nM. TLR7 agonist 1 activates downstream immune regulation and shows no activity against TLR8. TLR7 agonist 1 induces endogenous IFN-α production in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2178156-33-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111358. | |
| TLR7 agonist 2 | TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1642857-69-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103039. | |
| TLR9-IN-1 | TLR9-IN-1 is a potent and selective TLR9 inhibitor with an IC50 value of 7 nM for human TLR9. TLR9-IN-1 can be used for researching diseases associated with undesirable immune response[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226366-86-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148045. | |
| tLyP-1 peptide | tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. tLyP-1 peptide specifically binds to NRP-1 to target tumor cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1354801-55-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10787. | |
| TM-25659 | TM-25659 is a transcriptional co-activator with PDZ-binding motif (TAZ) modulator. Anti-osteoporotic and anti-obesity activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 260553-97-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112920. | |
| TM5441 | TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1190221-43-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101761. | |
| TMA chloride-d12 chloride | Tetramethylammonium-d12 (chloride) is the deuterium labeled Tetramethylammonium chloride[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tetramethylammonium chloride-d12 chloride. CAS No. 23789-03-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W012954S. | |
| TMAD | TMAD. Group: Biochemicals. Alternative Names: 1,1'-Azobis(N,N'-dimethylformamide); N, N, N', N'-Tetra methyl azodicarboxamide. Grades: Highly Purified. CAS No. 10465-78-8. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C6H12N4O2. US Biological Life Sciences. | Worldwide |
| TMA-DPH | TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 115534-33-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0986. | |
| TMAH | Tetramethylammonium hydroxide is a solid in the hydrated form or a colorless liquid with a strong ammonia-like odor. It is soluble in water. It is corrosive to metals and tissue.;Liquid. CAS No. 75-59-2. Molecular formula: C4H13NO. Mole weight: 91.15g/mol. IUPAC Name: tetramethylazanium;hydroxide. SMILES: C[N+](C)(C)C.[OH-]. InChI: InChI=1S/C4H12N.H2O/c1-5(2,3)4;/h1-4H3;1H2/q+1;/p-1. |  |
| TMAH-22 (Tetramethylammonium hydroxide aq. solution) | TMAH-22 (Tetramethylammonium hydroxide aq. solution). CAS No. 75-59-2. | |
| TMAH-25 (Tetramethylammonium hydroxide aq. solution) | TMAH-25 (Tetramethylammonium hydroxide aq. solution). CAS No. 75-59-2. | |
| TMB | TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BM blue; Sure Blue TMB. CAS No. 54827-17-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-15930. | |
| TMB dihydrochloride x.hydrate | TMB (dihydrochloride x.hydrate) is the dihydrochloride x hydrate form of TMB (HY-15930). TMB (dihydrochloride x.hydrate) is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB (dihydrochloride x.hydrate) can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB (dihydrochloride x.hydrate) can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sure Blue TMB dihydrochloride x.hydrate. CAS No. 207738-08-7. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-15930B. | |
| TMBIM6 antagonist-1 | TMBIM6 antagonist-1, a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 123134-61-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-137175. | |
| TMC-135A | TMC-135A is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60 with IC50 values of 0.07, 0.88, 0.11, 0.20, 0.15 and 0.05 μmol/L, respectively. Synonyms: TMC-135 A. Molecular formula: C39H49N3O8S. Mole weight: 719.9. |  |
| TMC-135B | TMC-135B is a triene-ansamycin antibiotic produced by Streptomyces sp. TC 1190. It is cytotoxic to HCT-116, SK-BR-3, HeLa S3, WiDr, HT29 and HL-60. Synonyms: TMC-135 B. Molecular formula: C39H49N3O8S. Mole weight: 719.9. | |
| TMC-154 | TMC-154 is an antibiotic produced by Gliocladium sp. TC 1282. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC 154. Molecular formula: C41H72O14. Mole weight: 789. | |
| TMC-169 | TMC-169 is an antibiotic of the aspochalasin group produced by Aspergillus flavipes TC 1446. It has cytotoxicity. Synonyms: TMC 169. Molecular formula: C24H35NO3. Mole weight: 385.5. | |
| TMC-171A | TMC-171A is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 A. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171B | TMC-171B is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 B. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-171C | TMC-171C is a polyketide antibiotic produced by Gliocladium sp. TC 1304. It has cytotoxicity to cancer cells like HCT-1l6, H-60, U937, WiDr. Synonyms: TMC-171 C. Molecular formula: C41H72O15. Mole weight: 805. | |
| TMC-1A | TMC-1A is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 A. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1B | TMC-1B is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 B. Molecular formula: C28H36N2O7. Mole weight: 512.6. | |
| TMC-1C | TMC-1C is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 C. Molecular formula: C30H38N2O7. Mole weight: 538.6. | |
| TMC-1D | TMC-1D is a Manumycin-associated antibiotic produced by Streptomyces sp. A-230. It has activity against gram-positive bacteria and cytotoxicity to various cancer cells. Synonyms: TMC-1 D. Molecular formula: C30H40N2O7. Mole weight: 540.6. | |
| TMC-256A1 | TMC-256A1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 25 μmol/L. Synonyms: TMC-256 A1. CAS No. 3773-18-0. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-256C1 | TMC-256C1 is an inhibitor of IL-4 signal transduction isolated from the fermentation broth of Aspergillus niger var niger TC 1629. It inhibited the IL-4 driven luciferase activity with IC50 values of 1.7 μmol/L. Synonyms: TMC-256 C1. Molecular formula: C15H12O5. Mole weight: 272.25. | |
| TMC-260 | TMC-260 is an inhibitor of IL-4 signal transduction produced by Acremonium kiliense Grütz TC 1703. It inhibited the IL-4 driven luciferase activity with IC50 values of 9 μmol/L. Synonyms: TMC 260. Molecular formula: C17H27NO5. Mole weight: 325.4. | |
| TMC-264 | TMC-264 is a STAT6 activation inhibitor produced by Phoma sp. TC 1674. It suppressed expression of IL-4 driven luciferase and germline Cepsilon mRNA with IC50 values of 0.3 and 0.4 μmol/L, respectively, and inhibited tyrosine phosphorylation of STAT6 with an IC50 value of 1.6 μmol/L. Synonyms: TMC 264. Molecular formula: C16H13ClO7. Mole weight: 352.72. | |
| TMC-2A | TMC-2A is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 A. Molecular formula: C28H34N4O9. Mole weight: 570.6. | |
| TMC-2B | TMC-2B is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 B. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC-2C | TMC-2C is a dipeptidyl peptidase IV (DPIV) inhibitor isolated from the fermentation broth of Aspergillus oryzae A374. It inhibited rat kidney DPIV with IC50 value of 8.1 μmol/L. Synonyms: TMC-2 C. Molecular formula: C28H34N4O8. Mole weight: 554.6. | |
| TMC-34 | TMC-34 is an macrolide antifungal antibiotic produced by Streptomyces sp. A-3030. Synonyms: TMC 34. Molecular formula: C54H93N3O17. Mole weight: 1056.3. | |
| TMC-49A | TMC-49A is a transcriptional up-regulator of low density lipoprotein receptor. It is produced by Streptomyces sp. AS1345. It enhanced the synthesis of LDL receptor in human hepatoma HepG2 cells as assessed by a receptor binding assay. Synonyms: TMC-49 A; 2-phenylethyl n-butyl carbamate. Molecular formula: C13H19NO2. Mole weight: 221.29. | |
| TMC-52A | TMC-52A is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 13 nM. Synonyms: TMC-52 A. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52B | TMC-52B is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 B. Molecular formula: C20H30N4O6. Mole weight: 422.5. | |
| TMC-52C | TMC-52C is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 10 nM. Synonyms: TMC-52 C. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-52D | TMC-52D is a cysteine proteinase inhibitor produced by Gliocladium sp. F-2665. It strongly inhibited cysteine proteinases, in particular, cathepsin L with IC50 value of 6 nM. Synonyms: TMC-52 D. Molecular formula: C20H30N4O5. Mole weight: 406.5. | |
| TMC-58B | Aurantiamide, a natural alkaloid found in the herbs of Walsura yunnanensis, is used as significant anti-inflammatory and antinociceptive. it can serve as the natural compound for inhibiting cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. It may suppress the growth of malignant gliomas by blocking autophagic flux. Uses: Anti-neuroinflammatory; anti-inflammatory; antinociceptive. Synonyms: (S)-α-(Benzoylamino)-N-[(S)-1-(hydroxymethyl)-2-phenylethyl]benzenepropanamide. Grade: >95%. CAS No. 58115-31-4. Molecular formula: C25H26N2O3. Mole weight: 402.5. | |
| TMC-66 | TMC-66 is a selective endothelin conversion enzyme (ECE) inhibitor isolated from the culture broth of Streptomyces sp. A5008. Synonyms: TMC 66. Molecular formula: C29H21NO9. Mole weight: 527.5. | |
| TMC-69 | TMC-69 is an antitumor antibiotic isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. It exhibited moderate in vitro cytotoxic activity. Synonyms: TMC 69. Molecular formula: C26H31NO4. Mole weight: 421.5. | |
| TMC-86A | TMC-86A is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 5.1 and 3.7 μmol/L, respectively. Synonyms: TMC-86 A. Molecular formula: C16H26N2O6. Mole weight: 342.39. | |
| TMC-86B | TMC-86B is a 20S proteasome inhibitor isolated from the fermentation broth of Streptomyces sp. A5008. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 1.1 and 31 μmol/L, respectively. Synonyms: TMC-86 B. Molecular formula: C20H34N2O7. Mole weight: 414.5. | |
| TMC-89A | TMC-89A is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.39 and 7.2 μmol/L, respectively. Synonyms: TMC-89 A; N-[(2R)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-89B | TMC-89B is a 20S proteasome inhibitor produced by streptomyces sp. TC 1087. It inhibited chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 of 1.1, 0.51 and 7.1 μmol/L, respectively. Synonyms: TMC-89 B; N-[(2S)-3-amino-2-methyl-3-oxopropanoyl]-L-threonyl-N-{1-[2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl}-L-threoninamide. Molecular formula: C21H36N4O9. Mole weight: 488.5. | |
| TMC-95A | TMC-95A is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome with IC50 values of 5.4nM, 200nM, and 60nM, respectively. Synonyms: TMC-95 A. CAS No. 220666-21-7. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95B | TMC-95B is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. It inhibited the chymotrypsin-like (ChT-L), trypsin-like (T-L), and peptidylglutamyl-peptide hydrolyzing (PGPH) activities of 20S proteasome to the same extent as TMC-95A. Synonyms: TMC-95 B. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95C | TMC-95C is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 C. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-95D | TMC-95D is a proteasome inhibitor produced by Apiospora montagnei Sacc. TC 1093. Synonyms: TMC-95 D. Molecular formula: C33H38N6O10. Mole weight: 678.7. | |
| TMC-96 | TMC-96 is a proteasome inhibitor produced by Saccharothrix sp. TC 1094. It inhibited the chymotrypsin-like and peptidylglutamyl-peptide hydrolyzing activities of 20S proteasome with IC50 values of 2.9 and 3.5 μmol/L, respectively. Synonyms: TMC 96. Molecular formula: C18H32N2O6. Mole weight: 372.5. | |
| TMCB | TMCB. Group: Biochemicals. Grades: Purified. CAS No. 905105-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TMCHA | TMCHA. Mole weight: 196. | |
| TMDJ-035 | TMDJ-035 is a high-affinity, selective RyR2 inhibitor with an EC50 of 0.0130 μM. TMDJ-035 reduces RyR2 protein expression without affecting action potential-induced Ca2+ transients. TMDJ-035 decreases ATP content and intracellular Ca2+ levels. TMDJ-035 inhibits arrhythmias in a CPVT mouse model carrying mutant RyR2s. TMDJ-035 has no effect on electrocardiogram parameters or cardiac systolic function. TMDJ-035 exacerbates heart failure in mouse myocardial infarction models and hypoxic cardiomyocytes by altering cardiac function, causing tissue damage, promoting inflammatory infiltration, collagen deposition, and changes in Myosin heavy chain/actin expression. TMDJ-035 can be used in studies related to heart failure, catecholaminergic polymorphic ventricular tachycardia, and arrhythmias[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2681302-83-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149662. | |
| TMEM16A Activator, Eact (3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide, ANO1 Activator) | An N-aroylaminothiazole that strongly activates TMEM16A (ANO1) calcium-activated chloride channel (CaCC) at 0 Ca2+ concentration (Ca2+ independent), with the capability of producing large and sustained CaCC Cl-1 currents (EC50=3uM) in TMEM16A-expressing Fisher Rat Thyroid (FRT) Cells without elevation of cytoplasmic Ca2+ level, and in human A253 cells. Shown to increase CaCC conductance in human salivary and airway submucosal gland epithelial cells, IL-4 treated bronchial cells, and stimulated submucosal gland secretion in human bronchi and smooth muscle contraction in mouse intestine. Activation effect can be abolished by the addition of a TMEM16A inhibitor T16A-A01 at 10uM in TMEM16A-transfected cells and in cultures of human salivary gland and IL-4-treated bronchial epithelia, but not in intestine. Does not affect CFTR Cl- conductance or ENaC Na+ conductance. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TMEM16A Inhibitor, T16Ainh-A01 (2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, ANO1 Inhibitor, T16Ainh-A01, TMEM16A Antagonist, T16Ainh-A01) | An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50=1.1uM). Fully blocks CaCC current in salivary gland cells at 10uM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact at 10uM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TMEM175 modulator 1 | TMEM175 modulator 1 (compound 47) is a TMEM175 modulator.TMEM175 modulator 1 modulates activity of the lysosomal potassium ion channel TMEM175.TMEM175 modulator 1 can be used for the research of parkinsons disease, dementia, alzheimers disease, l-dopa induced dyskinesia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3038770-25-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162666. | |
| TMI-1 | TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC50 of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α, IL-1β, IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WAY-171318. CAS No. 287403-39-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101448. | |
| TML-6 | TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimers disease (AD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1462868-88-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137315. | |
| TM-N1324 | TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39. Uses: Scientific research. Category: Signaling pathways. CAS No. 1144477-35-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108699. | |
| TMN 355 | TMN 355. Group: Biochemicals. Grades: Purified. CAS No. 1186372-20-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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