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| Product | Description | |
|---|---|---|
| TMP(15)EOTA | TMP(15)EOTA. Mole weight: 956. |  |
| TMP195 | TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with Kis of 59, 60, 26, 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314891-22-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18361. |  |
| TMP(20)EOTA | TMP(20)EOTA. Mole weight: 1176. | |
| TMP269 | TMP269 Inhibitor. Uses: Scientific use. Product Category: T1857. CAS No. 1314890-29-3. |  |
| TMP269 | TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314890-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-18360. | |
| TMP(3)EOTA | TMP(3)EOTA. Mole weight: 428. | |
| TMP(3)EOTA-TF | TMP(3)EOTA-TF. Mole weight: 428. | |
| TMP(3)POTA | TMP(3)POTA. Mole weight: 470. | |
| TMP(4)EOTA | TMP(4)EOTA. Mole weight: 499. | |
| TMP(6)EOTA | TMP(6)EOTA. Mole weight: 560. | |
| TMP778 | TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay. Uses: Scientific research. Category: Signaling pathways. CAS No. 1422053-04-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102075A. | |
| TMP(9)EOTA | TMP(9)EOTA. Mole weight: 692. | |
| TMPD dihydrochloride | TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases[1][2]. TMPD dihydrochloride is also a complex IV substrate[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 637-01-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-W012145. | |
| TMPEOTA 28961-43-5 | TMPEOTA 28961- - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY. |  North America & APAC |
| TMPTA | 500g Pack Size. Group: Building Blocks, Organics. Formula: C15H20O6. CAS No. 15625-89-5. Prepack ID 90027098-500g. Molecular Weight 296.32. See USA prepack pricing. |  |
| TMPTA | 1kg Pack Size. Group: Building Blocks, Organics. Formula: C15H20O6. CAS No. 15625-89-5. Prepack ID 90027098-1kg. Molecular Weight 296.32. See USA prepack pricing. | |
| TMPTA | TMPTA. Mole weight: 296. | |
| TMPTA-TF | TMPTA-TF. Mole weight: 296. | |
| TMPTMA | TMPTMA. Mole weight: 338. | |
| Tmpyp | Tmpyp. Alternative Names: 5,10,15,20-TETRAKIS-(N-METHYL-4-PYRIDYL)-21,23H-PORPHYRIN TETRATOSYLATE;5,10,15,20-TETRAKIS (1-METHYL-4-PYRIDINIO) PORPHINE TETRA (P-TOLUENESULFONATE);5,10,15,20-TETRAKIS(1-METHYL-4-PYRIDINIO)-PORPHYRIN TETRA(P-TOLUENESULFONATE);5,10,15,20-TETRAKIS(1-METH. CAS No. 36951-72-1. Molecular formula: C72H66N8O12S4. Mole weight: 1363.6. Purity: >95 %. IUPAC Name: 4-methylbenzenesulfonate; 5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,22-dihydroporphyrin. | |
| TMPyP4 tosylate | TMPyP4 tosylate. Group: Biochemicals. Grades: Purified. CAS No. 36951-72-1. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| TMPyP4 tosylate | TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2[1][2][3][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMP 1363. CAS No. 36951-72-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108477. | |
| TmPyPB | TmPyPB. Alternative Names: 1,3,5-Tri(m-pyridin-3-ylphenyl)benzene,1,3,5-Tris(3-pyridyl-3-phenyl)benzene,Tm3PyPB. CAS No. 921205-03-0. Molecular formula: C39H27N3. Mole weight: 537.65. IUPAC Name: 3-[3-[3,5-bis(3-pyridin-3-ylphenyl)phenyl]phenyl]pyridine. SMILES: C1(C2=CC=CC(C3=CN=CC=C3)=C2)=CC(C4=CC=CC(C5=CN=CC=C5)=C4)=CC(C6=CC=CC(C7=CN=CC=C7)=C6)=C1. InChI: 1S/C39H27N3/c1-7-28(34-13-4-16-40-25-34)19-31(10-1)37-22-38(32-11-2-8-29(20-32)35-14-5-17-41-26-35)24-39(23-37)33-12-3-9-30(21-33)36-15-6-18-42-27-36/h1-27H,CINYXYWQPZSTOT-UHFFFAOYSA-N. | |
| TMPyP tetrachloride | TMPyP tetrachloride is a DNA-binding agent, singlet oxygen Sensitizer and photobleaching agent. TMPyP tetrachloride binds to DNA via intercalation or external groove complexation; irradiation induces its photoinduced release from DNA. TMPyP tetrachloride sensitizes the generation of singlet molecular oxygen upon irradiation, and prolonged irradiation leads to photobleaching. TMPyP tetrachloride initially localizes preferentially in neuronal nuclei and cytoplasm, and irradiation triggers its subcellular relocalization. TMPyP tetrachloride binds to K+ -free single-molecule G4-DNA nanowires via intercalation, and binds to K+ -type variants via non-intercalation. TMPyP tetrachloride can be used in studies related to cancer, HIV infection and bacterial infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 92739-63-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W112938. | |
| TMRE | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tetramethylrhodamine ethyl ester perchlorate. CAS No. 115532-52-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0985A. | |
| TMRM Perchlorate | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: T668. CAS No. 115532-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0984A. | |
| TMRM Perchlorate (solution) | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1].Solvent and concentration: DMSO: 10 mM. Uses: Scientific research. Category: Signaling pathways. CAS No. 115532-50-8. Pack Sizes: 500 μL; 1 mL. Product ID: HY-DY1042. | |
| TMR PA | TMR PA. Group: Others. Purity: >99%. Mole weight: 946.904. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PA; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3- phosphate (ammonium salt). Cat No: FLBZ-157. |  |
| TMR PC | TMR PC. Group: Others. Purity: >99%. Mole weight: 1015.021. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PC; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-Diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine. Cat No: FLBZ-151. | |
| TMR PE | TMR PE. Group: Others. Purity: >99%. Mole weight: 972.941. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PE; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3- phosphoethanolamine. Cat No: FLBZ-156. | |
| TMR PS | TMR PS. Group: Others. Purity: >99%. Mole weight: 1033.981. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; TMR PS; 1-Oleoyl-2-(6-((4,4-difluoro-1,3-Dimethyl-5-(4-methoxyphenyl)-4-bora-3a,4a-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3- phospho-L-serine (ammonium salt). Cat No: FLBZ-149. | |
| TMS | TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC50 of 6 nM and a Ki value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC50=300 nM) and CYP1A2 (IC50=3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (E)-2,3',4,5'-tetramethoxystilbene. CAS No. 24144-92-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19340. | |
| TMS | TMS. Group: Biochemicals. Grades: Purified. CAS No. 24144-92-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TMX1 | TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2, forms covalent bonds with Cys58 of DCAF16 and Cys87 of GAK in a BRD4BD2-dependent template-assisted manner, stabilizes the BRD4-TMX1-DCAF16 ternary complex, and promotes the ubiquitination of BRD4 via the CRL4DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4, mild degradation of BRD2 and BRD3, as well as DCAF16-dependent cytotoxicity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3079093-92-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153385. | |
| TMX-2039 | TMX-2039 is a pan-CDK inhibitor for both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5 and CDK6) and transcriptional CDKs (CDK7 and CDK9), with IC50s of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5 and 25 nM, respectively. TMX-2039 acts as a Ligands for Target Protein for PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488892-01-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151069. | |
| TMX-2172 | TMX-2172 is a selective bivalent cereblon-recruiting PROTAC-based dual CDK2 and CDK5 degrader with IC50 values of 6.5 nM and 6.8 nM, respectively. TMX-2172 shows selectivity for CDK2 and CDK5 over other cell cycle CDKs (CDK1, CDK4, and CDK6) and transcriptional CDKs (CDK7 and CDK9). TMX-2172 inhibits CDK2/CDK5 enzymatic activity, induces their proteasomal degradation, reduces ASCL1 protein levels and half-life, induces cancer cell death, and exerts antiproliferative effects. TMX-2172 can be used for the research of ovarian cancer and small cell lung cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488892-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155218. | |
| TMX-3013 | TMX-3013 is a CDK inhibitor capable of inhibiting the activity of CDK1, CDK2, CDK4, CDK5, and CDK6, with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM, respectively. TMX-3013 can be used as a target protein ligand, conjugated with the PROTAC linker and the CRBN ligand Thalidomide (HY-14658) for the synthesis of PROTAC TMX-2138 (HY-164906). TMX-3013 can also act as an effector ligand, binding to target proteins HaloTag or FKBP, and can be used in the synthesis of regulated induced proximity targeting chimeras (RIPTACs)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488761-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151071. | |
| TMX-4100 | TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2367619-63-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145321. | |
| TMX-4113 | TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2766385-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145320. | |
| TMX-4116 | TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2766385-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145322. | |
| TMX-4153 | TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation)-related diseases. (Pink: BTK ligand (HY-177432), Blue: VHL Ligand (HY-112078), Black: Linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2867519-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153119. | |
| TMZ(Temozolomide) | TMZ(Temozolomide) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210 / BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity. Group: Inhibitors. Alternative Names: NSC 362856,CCRG 81045,Methazolastone. CAS No. 85622-93-1. Pack Sizes: 25mg. Product ID: S1237. Formula: C6H6N6O2. Smiles: CN1C(=O)N2C=NC(=C2N=N1)C(=O)N. Storage Conditions: (in dark and seal) . |  United States; Europe |
| Tn5 Transposase | Tn5 Transposase is a hyperactive form of Tn5 transposase. This enzyme can be used to randomly insert Tn5 transposon into target DNA. Robust Tn5 Transposase recognizes inside end sequences, outside end sequences and mosaic end sequences of Tn5 transposon. Applications: In vitro transgenic experiment;construction of random library for second-generation sequencing. Group: Enzymes. Synonyms: Transposase. Storage: Store at -20°C. Source: E.coli. Tn5 Transposase; Transposase. Cat No: NATE-1629. | |
| Tn-AFP 1 | Tn-AFP 1 is an antimicrobial peptide isolated from Trapa natans. It has activity against fungi. Synonyms: Leu-Met-Cys-Thr-His-Pro-Leu-Asp-Cys-Ser-Asn. |  |
| TNAP-IN-1 | TNAP-IN-1 (Compound 1) is a selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, with an IC50 of 0.19 μM. TNAP-IN-1 can be used for the research of soft tissue calcification[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 496014-13-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14210. | |
| TNBT Diformazan, AR | TNBT Diformazan, AR. CAS No. 19333-63-2. Molecular formula: C40H30N12O10. Mole weight: 838.7g/mol. IUPAC Name: N-[2-methoxy-4-[3-methoxy-4-[[(Z)-N-(4-nitroanilino)-C-(4-nitrophenyl)carbonimidoyl]diazenyl]phenyl]phenyl]imino-4-nitro-N'-(4-nitroanilino)benzenecarboximidamide. SMILES: COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC(=NNC3=CC=C(C=C3)[N+](=O)[O-])C4=CC=C(C=C4)[N+](=O)[O-])OC)N=NC(=NNC5=CC=C(C=C5)[N+](=O)[O-])C6=CC=C(C=C6)[N+](=O)[O-]. InChI: InChI=1S/C40H30N12O10/c1-61-37-23-27(7-21-35(37)43-47-39(25-3-13-31(14-4-25)49(53)54)45-41-29-9-17-33(18-10-29)51(57)58)28-8-22-36(38(24-28)62-2)44-48-40(26-5-15-32(16-6-26)50(55)56)46-42-30-11-19-34(20-12-30)52(59)60/h3-24,41-42H,1-2H3/b45-39-,46-40-,47-43?,48-44?. | |
| TNF-α (10-36), human | TNF-α (10-36), human is a peptide of human TNF-α. Synonyms: Asp-Lys-Pro-Val-Ala-His-Val-Val-Ala-Asn-Pro-Gln-Ala-Glu-Gly-Gln-Leu-Gln-Trp-Leu-Asn-Arg-Arg-Ala-Asn-Ala-Leu; L-Leucine, L-α-aspartyl-L-lysyl-L-prolyl-L-valyl-L-alanyl-L-histidyl-L-valyl-L-valyl-L-alanyl-L-asparaginyl-L-prolyl-L-glutaminyl-L-alanyl-L-α-glutamylglycyl-L-glutaminyl-L-leucyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-asparaginyl-L-arginyl-L-arginyl-L-alanyl-L-asparaginyl-L-alanyl-; tumor necrosis factor-alpha fragment 10-36 human. Grade: >95%. CAS No. 144796-70-3. Molecular formula: C131H211N43O38. Mole weight: 2996.34. | |
| TNF-α (31-45), human | TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144796-71-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1860. | |
| TNF-α (46-65), human | TNF-α (46-65), human is a compound accomplishing its efficacy by specifically targeting a fragment of Tumor Necrosis Factor-alpha (TNF-α), finding purpose in the studyof diverse conditions, encompassing rheumatoid arthritis, psoriasis, Crohn's disease and ulcerative colitis. Synonyms: H-Asn-Gln-Leu-Val-Val-Pro-Ser-Glu-Gly-Leu-Tyr-Leu-Ile-Tyr-Ser-Gln-Val-Leu-Phe-Lys-OH. Grade: 98%. CAS No. 144796-72-5. Molecular formula: C110H172N24O30. Mole weight: 2310.69. | |
| TNF-α Antagonist | TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex, thus preventing ligand interaction with the receptor. Synonyms: W9; H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (Disulfide bridge: Cys2-Cys8); L-tyrosyl-L-cysteinyl-L-tryptophyl-L-seryl-L-glutaminyl-L-tyrosyl-L-leucyl-L-cysteinyl-L-tyrosine (2->8)-disulfide; WP9QY; N-{[(4R,7S,10S,13S,16S,19S,22R)-13-(3-Amino-3-oxopropyl)-10-(4-hydroxybenzyl)-16-(hydroxymethyl)-19-(1H-indol-3-ylmethyl)-7-isobutyl-6,9,12,15,18,21-hexaoxo-22-(L-tyrosylamino)-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosan-4-yl]carbonyl}-L-tyrosine. Grade: ≥95%. CAS No. 199999-60-5. Molecular formula: C58H71N11O15S2. Mole weight: 1226.38. | |
| TNF-α-IN-1 | TNF-α-IN-1 (Compound I-7) is a TNF-α inhibitor. TNF-α-IN-1 can be studied in research for cancers, heart disease, autoimmune disease and infections[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 444287-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112275. | |
| TNF-α-IN-2 | TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC50 of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2074702-04-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134471. | |
| TNF-α-IN-6 | TNF-α-IN-6 (compound 12) is an orally effective allosteric inhibitor of TNFα (KD = 6.8 nM). TNF-α-IN-6 has anti-inflammatory effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2699704-20-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142618. | |
| TNG260 | TNG260 is a selective, orally effective inhibitor of HDAC1 and CoREST complex, with a 10-fold selectivity for HDAC1 over HDAC3 and a 500-fold selectivity for CoREST complex over NuRD and Sin3 complex. TNG260 reshapes the tumor immune microenvironment, reduces immunosuppressive neutrophil infiltration, promotes effector T cell recruitment, and reverses anti-PD-1 resistance caused by STK11 deficiency by inhibiting the activity of the CoREST-HDAC1 complex. TNG260 induces durable tumor regression in combination with α-PD1 in MC38 tumor-bearing mice with STK11 mutations, and has lower toxicity to bone marrow cells than non-selective HDAC inhibitors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2935964-98-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153358. | |
| TNG348 | TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2839740-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160700. | |
| TNIK-IN-5 | TNIK-IN-5 is an efficient TNIK inhibitor with IC50 of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2754265-66-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143437. | |
| TNIK-IN-6 | TNIK-IN-6 (Compound 9) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK) and , with IC50 of 0.93 μM, that plays important roles in neurological and psychiatric disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375196-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-156817. | |
| TNIK-IN-7 | TNIK-IN-7 (Compound 8) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 11 nM, that has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1417795-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156818. | |
| TNIK-IN-8 | TNIK-IN-8 (Compound 35b) is a potent, orally active TNKI inhibitor with a IC50 value of 6 nM. TNIK-IN-8 has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3068941-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162314. | |
| TNO155 | TNO155 Inhibitor. Uses: Scientific use. Product Category: T13176. CAS No. 1801765-04-7. | |
| TNP | TNP. Group: Biochemicals. Grades: Purified. CAS No. 519178-28-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TNP | TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC50s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 519178-28-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110079. | |
| TNP-470 | TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGM-1470. CAS No. 129298-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-101932. | |
| TNP-470 (AGM-1470, O-(Chloroacetyl-carbamoyl)fumagillol, AGM1470, MetAP-2 Inhibitor II, MetAP2 Inhibitor II, Methionine Aminopeptidase 2 Inhibitor II, TNP470) | A cell-permeable Fumagillin analog that inhibits MetAP2, but not MetAP1, methionine aminopeptidase activity (IC50 = 1nM against human MetAP2), without affecting the inhibitory activity of MetAP2 against HRI- (heme-regulated inhibitor kinase) catalyzed eIF-2alpha phosphorylation. A potent endothelial cytostasis inducer (IC50 = 25 pM and 37 pM, respectively, against HUVEC and bovine BAEC) in vitro and an effective anti-angiogenesis agent in vivo (2-100mg/kg in mice and rats; s.c.). Group: Biochemicals. Grades: Highly Purified. CAS No. 129298-91-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TNP-ATP triethylammonium salt | TNP-ATP triethylammonium salt. Group: Biochemicals. Grades: Purified. CAS No. 61368-63-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TNP (N6-[ (4-nitrophenyl) methyl]-N2-[[3- (trifluoromethyl) phenyl]methyl]-9H-Purine-2, 6-diami ne) | Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47um for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2um). Binds to the ATP binding site of IP3K (Ki = 4.3um). Group: Biochemicals. Grades: Highly Purified. CAS No. 519178-28-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TNS sodium | TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-(p-Tolylamino)naphthalene-2-sulfonate sodium. CAS No. 53313-85-2. Pack Sizes: 100 mg; 250 mg. Product ID: HY-W250727. | |
| ToAMP4 | ToAMP4 is an antimicrobial peptide isolated from Taraxacum officinale. It has activity against fungi. Synonyms: Gly-Tyr-Gly-Asp-Gly-Cys-Tyr-Ser-Glu-Asp-Asp-Leu-Ser-Val-Cys-Cys-Lys-Lys-Lys-Phe-Lys-Val-Ile-Gly-Lys-Cys-Phe-Lys-Ser-Val-Arg-Glu-Cys-Gln-Asn-Ser-Gly-Cys-Lys-Tyr-His. | |
| Tobacco Etch Virus Protease, Recombinant | Recombinant TEV Protease is a site-specific protease purified from E. coli by the affinity tag, GST tag. The protease can be used for the removal of affinity tags from fusion proteins. The seven-amino-acid recognition site for TEV protease is Glu-Asn-Leu-Tyr-Phe-Gln-Gly with cleavage occurring between Gln and Gly. The optimal temperature for cleavage is 30°C; however, the enzyme can be used at temperatures as low as 4°C. Following digestion, TEV protease can be removed from the reaction via the GST tag sequence by affinity chromatography. Applications: A number of variables can be changed to optimize the cleavage of any specific protein. the amount of tev protease, the temperature of the incubation, and the time needed for cleavage may be examined. if the protein of interest is heat-labile, then 4°c incubations are recommended. reactions at 4°c will require longerincubation times and/or more tev protease. Group: Enzymes. Synonyms: TEV protease; Tobacco Etch Virus nuclear inclusion a endopeptidase; Tobacco Etch Virus Protease. Purity: >90% by SDS-PAGE. TEV Protease. Appearance: Clear colorless liquid. Storage: Store recombinant TEV protease at -70°C for long term or at -20°C for < 6 months. Source: E. coli. TEV protease; Tobacco Etch Virus nuclear inclusion a endopeptidase; Tobacco Etch Virus Protease. Cat No: NATE-0922. | |
| Tobevibart | Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VIR-3434. CAS No. 2645440-65-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990015. | |
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