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| Product | Description | |
|---|---|---|
| Tartronic Acid (Hydroxymalonic Acid) | Tartronic Acid (Hydroxymalonic Acid). Group: Biochemicals. Alternative Names: Hydroxymalonic acid; Propanedioic acid, hydroxy-; Malonic acid, hydroxy-; 2-Hydroxypropanedioic acid;2-Hydroxypropanedioic acid; EINECS 201-301-1; MALONIC ACID, HYDROXY-; NSC 36171; Tartronic acid; UNII-34T0025E0L; Propanedioic acid, hydroxy-; Propanedioic acid, hydroxy- (9CI); Tartronic acid. Grades: Highly Purified. CAS No. 80-69-3. Pack Sizes: 100mg. Molecular Formula: C?H?O?, Molecular Weight: 120.06. US Biological Life Sciences. |  Worldwide |
| TAS0728 | TAS0728 is a potent and seletive HER2 inhibitor possibly used for the treatment of various cancers. It covalently binds to HER2 at C805 and selectively inhibits its kinase activity. Synonyms: (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-N-(4-(2-(dimethylamino)-2-oxoethyl)-2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide. CAS No. 2088323-16-2. Molecular formula: C26H32N8O3. Mole weight: 504.6. |  |
| TAS-102 | TAS-102 is a combination drug composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2'-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI). TAS-102 is used as a third- or fourth-line treatment of metastatic colorectal cancer. Synonyms: Tipiracil / Trifluridine; Viroptic mixture with 5-CIMU; TAS 102; EX-A1755; Tipiracil hydrochloride / Trifluridine. CAS No. 733030-01-8. Molecular formula: C9H11ClN4O2·HCl·C10H11F3N2O5. Mole weight: 575.328. | |
| TAS-103 | TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. TAS-103 may be useful in the chemotherapy of colorectal cancer. Uses: Topoisomerase i inhibitors. Synonyms: BMS-247615; TAS103; TAS 103; BMS247615; BMS 247615. Grades:>98%. CAS No. 174634-08-3. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| TAS-103 dihydrochloride | TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. Synonyms: 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride; TAS103; TAS-103; TAS 103; BMS247615; BMS 247615; BMS-247615. Grades:>98%. CAS No. 174634-09-4. Molecular formula: C20H21Cl2N3O2. Mole weight: 406.31. | |
| TAS-108 | TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues. In addition, TAS-108 activates the co-repressor Silencing Mediator for Retinoid and Thyroid hormone receptor (SMRT), a protein that inhibits the activities of the estrogen receptors, which may contribute to the antitumor activity of TAS-108. Synonyms: TAS108; TAS 108; SR16234; SR 16234; SR-16234; (7alpha)-21-(4-((Diethylamino)methyl)-2-methoxyphenoxy)-7-methyl-19-norpregna-1,3,5(10)-trien-3-ol 2-hydroxy-1,2,3-propanetricarboxylate. Grades: >98%. CAS No. 229634-98-4. Molecular formula: C39H55NO10. Mole weight: 697.86. | |
| TAS-115 | This active molecular is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented. Uses: Solid tumours. Synonyms: TAS-115; TAS 115; TAS115; 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide. Grades: 98%. CAS No. 1190836-34-0. Molecular formula: C27H23FN4O4S. Mole weight: 518.56. | |
| TAS-116 | TAS-116 is a inhibitor of Hsp90. It induces significant cytotoxicity in MM cells even in the presence of BMSCs, associates with downregulation of phospho-Akt and phospho-ERK. In addition, neither exogenous IL-6 nor IGF-1 was able to protect against TAS-116. Importantly, TAS-116 did not induce cytotoxicity in BMSCs. TAS-116 enhanced bortezomib-induced cytotoxicity in MM.1S and RPMI-8226 cells, associated with decreased phospho-Akt, phospho-RelA (p65), phospho-IkBa, and phospho-IKKα/β; as well as increased CHOP and PARP cleavage. These results suggest that TAS-116 blocks bortezomib-induced canonical NF-κB pathway and augments bortezomib-induced endoplasmic reticulum (ER) stress. Synonyms: TAS116; TAS 116; TAS-116; 3-Ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]benzamide. Grades: >98%. CAS No. 1260533-36-5. Molecular formula: C25H26N8O. Mole weight: 454.54. | |
| TAS-119 | TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC 50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B ( IC 50 of 95 nM). TAS-119 has potent antitumor activites [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1453099-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137377. |  |
| TAS 301 | TAS 301. Group: Biochemicals. Grades: Purified. CAS No. 193620-69-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TAS-301 | TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery. TAS-103 inhibits smooth muscle cell migration and proliferation. Synonyms: TAS-301; TAS301; TAS301. Grades: 98%. CAS No. 193620-69-8. Molecular formula: C23H19NO3. Mole weight: 357.41. | |
| TAS4464 | TAS4464 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. It selectively inhibits NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IkBa in human cancer cell lines. Synonyms: 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-beta-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]-. CAS No. 1848959-10-3. Molecular formula: C21H23FN6O6S. Mole weight: 506.5. | |
| TAS4464 | TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) , with an IC 50 of 0.955 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1848959-10-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-128586. | |
| TAS4464 hydrochloride | TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE) , with an IC 50 of 0.955 nM [1]. TAS4464 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1848959-11-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128586A. | |
| TAS6417 | TAS6417 is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. TAS6417 inhibited EGFR phosphorylation and downstream molecules in NSCLC cell lines expressing EGFR exon 20 insertions, resulting in caspase activation. Synonyms: CLN-081; TPC-064; TAS 6417; TAS-6417; Zipalertinib. CAS No. 1661854-97-2. Molecular formula: C23H20N6O. Mole weight: 396.44. | |
| TaSe2 Crystal | Graphene-like Materials Series. Alternative Names: Tantalumdiselenide; tantalumselenide(tase2); TANTALUM SELENIDE;Tantalum(IV) selenide. CAS No. 12039-55-3. Molecular formula: Se2Ta. Mole weight: 338.87. Purity: 0.99995. Catalog: ACM12039553. |  |
| Taselisib | Taselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0.2nM, and with reduced inhibitory activity against PI3K. This selectivity profile, and excellent pharmacokinetic and pharmaceutical properties, allowed for greater efficacy in vivo at the maximum tolerated dose relative to a pan Class I PI3K inhibitor in PIK3CA mutant xenografts. Notably, GDC-0032 preferentially inhibited PIK3CA mutant cells relative to cells with wild-type PI3K. GDC-0032 potently inhibits signal transduction downstream of PI3K and induces apoptosis at low concentrations in breast cancer cell lines and xenograft models that harbor PIK3CA mutations. Synonyms: GDC-0032; GDC0032; GDC 0032; RG7604; RG-7604; RG 7604; Taselisib. CAS No. 1282512-48-4. Molecular formula: C24H28N8O2. Mole weight: 460.542. | |
| Taselisib | Taselisib (GDC-0032) is a potent PI3K inhibitor targets PIK3CA mutations, with K i s of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0032; RG-7604. CAS No. 1282512-48-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13898. | |
| Tasidotin hydrochloride | Tasidotin, also know as ILX-651, is an orally active synthetic microtubule-targeted derivative of the marine depsipeptide dolastatin-15, is currently undergoing clinical evaluation for cancer treatment. Tasidotin inhibited proliferation of MCF7/GFP breast cancer cells with an IC(50) of 63 nmol/L and inhibited mitosis with an IC(50) of 72 nmol/L in the absence of detectable effects on spindle microtubule polymer mass. Tasidotin inhibited the polymerization of purified tubulin into microtubules weakly (IC(50) approximately 30 micromol/L). However, it strongly suppressed the dynamic instability behavior of the microtubules at their plus ends at concentrations approximately 5 to 10 times below those required to inhibit polymerization. Synonyms: ILX 651; ILX651; ILX-651. CAS No. 623174-20-9. Molecular formula: C32H59ClN6O5. Mole weight: 643.31. | |
| Tasimelteon | Tasimelteon (trade name Hetlioz) is a drug approved by the FDA solely for the treatment of non-24-hour sleep-wake disorder (often designated as N24HSWD) in totally blind adults. It is a selective agonist for the melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, similar to other members of the melatonin receptor agonist class of which ramelteon (2005) and agomelatine (2009) were the first approved. Uses: Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. it helps to correct the circadian rhythm disorder often seen in patients who are visually impaired. Synonyms: BMS-214,778; BMS-214778; BMS214778; BMS 214778. VEC-162; VEC162; VEC 162. Trade name: Hetlioz. Grades: ≥ 99.0%. CAS No. 609799-22-6. Molecular formula: C15H19NO2. Mole weight: 245.32. | |
| Tasimelteon | Tasimelteon (BMS-214778) is an orally active and selective dual melatonin receptor agonist (DMRA). Tasimelteon has 2.1-4.4 times greater affinity for the MT2 receptor than for the MT1 receptor. Tasimelteon is a circadian regulator and has the potential for Non-24-Hour Sleep-Wake Disorder (Non-24) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-214778; VEC-162. CAS No. 609799-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14803. | |
| TASIN-1 | TASIN-1 is an inhibitor of adenomatous polyposis coli (APC) that kills colorectal cancer cells that express APC by reducing cellular cholesterol levels. It also inhibits AKT activity through a cholesterol-dependent manner. Synonyms: 1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine. Grades: ≥98%. CAS No. 792927-06-1. Molecular formula: C18H28N2O3S. Mole weight: 352.5. | |
| Tasipimidine sulfate | Tasipimidine sulfate is an orally active and selective α2A-adrenoceptor agonist with a p EC 50 of 7.57 against human α2A-adrenoceptor. Tasipimidine sulfate can be used for situational anxiety and fear research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1465908-73-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109075A. | |
| Tasisulam | Tasisulam is a small molecule anticancer drug that induces apoptosis through intrinsic pathways. It leads to the release of cytochrome c and caspase-dependent cell death. Tasisulam can inhibit the process of mitosis and induce vascular normalization. Synonyms: LY 573636; LY573636; N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide. Grades: >98%. CAS No. 519055-62-0. Molecular formula: C11H6BrCl2NO3S2. Mole weight: 415.11. | |
| Tasosartan | Tasosartan, a pyrido-pyrimidin derivative, has been found to be an angiotensin II receptor antagonist that could have probable effect against hypertension. It has been discontinued for some security problems by Wyeth. Synonyms: TASOSARTAN;2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[6,5-d]pyrimidin-7-one. Grades: 98%. CAS No. 145733-36-4. Molecular formula: C23H21N7O. Mole weight: 411.46. | |
| Tasosartan | Tasosartan is a long-acting angiotensin II ( AngII ) receptor antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WAY-ANA 756. CAS No. 145733-36-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-A0250. | |
| TASP 0390325 | TASP 0390325 is a potent and selective vasopressin V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor) with no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. TASP 0390325 increases ACTH levels in rats. TASP 0390325 has the potential use as antidepressant and anxiolytic. Synonyms: TASP0390325, TASP 0390325, TASP-0390325; 2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1642187-96-9. Molecular formula: C25H29ClFN5O4.HCl. Mole weight: 554.44. | |
| TASP-0415914 | Potent, orally applicable PI3K y inhibitor. PI3Ky is required for for T-cell and B-cell as well as mast cell migration and degranulation. As such, these kinases are attractive targets for potential anti-infmamatory drugs. TASP-0415914 has shown excellent results in cell based assays. It is orally available and has performed will in murine in vivo models. PI3Ky IC(50) 29nm, AKT IC(50) 294nm. Group: Biochemicals. Grades: Highly Purified. CAS No. 1292300-75-4. Pack Sizes: 1mg, 5mg. Molecular Formula: C13H17N5O3S, Target: PI3Kγ. US Biological Life Sciences. | Worldwide |
| TASP 0433864 | TASP 0433864 is a selective and positive allosteric modulator of mGlu2 receptor (EC50 = 199 and 206 nM for human and rat receptors, respectively) with no agonist activity at rat mGlu2 receptors. It displays weak activity against a range of neurotransmitter targets except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Synonyms: TASP0433864, TASP0433864, TASP0433864; (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide. Grades: ≥98% by HPLC. CAS No. 1431980-60-7. Molecular formula: C18H23N3O3. Mole weight: 329.39. | |
| Taspine | Taspine is an alkaloid isolated from Radix et Rhizoma Leonticis. It shows various pharmaceutical properties: bacteriostatic, wound healing, cytotoxicity, immunosuppression, acetilcholinesterase inhibition, and inhibition of the activity of tumor angiogenesis. Used as human acid beta-glucosidase inhibitor and for the treatment of Gaucher disease. Group: Biochemicals. Alternative Names: 1-[2-(Dimethylamino)ethyl]-3,8-dimethoxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione; Thaspine; NSC 688259; Taspin. Grades: Highly Purified. CAS No. 602-07-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Taspine | Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 602-07-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131502. | |
| Taspoglutide | Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist (EC50 = 0.06 nM) under investigation for treatment of type 2 diabetes. Synonyms: (N-((N-(L-histidyl)-2-aminoisobutyryl)-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamyl-glycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysyl)-2-aminoisobutyryl)-L-argininamide; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2. CAS No. 275371-94-3. Molecular formula: C152H232N40O45. Mole weight: 3339.71. | |
| Taspoglutide | Taspoglutide is a long-acting glucagon-like peptide 1 ( GLP-1 ) receptor agonist developed for treatment of type 2 diabetes, with an EC 50 value of 0.06 nM. Uses: Scientific research. Group: Peptides. Alternative Names: ITM077; R1583; BIM51077. CAS No. 275371-94-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0165. | |
| Tasquinimod | Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn 2+ binding domain of HDAC4 with K d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABR-215050. CAS No. 254964-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10528. | |
| Tasquinimod | Tasquinimod is a quinoline-3-carboxamide linomide analogue with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of action is not known. This agent has also been shown to augment the antineoplastic effects of docetaxel and androgen ablation in a murine model of prostate cancer involving human prostate cancer xenografts. Uses: For research used only. Synonyms: ABR215050, ABR-215050, ABR 215050, Tasquinimod. Grades: 0.98. CAS No. 254964-60-8. Molecular formula: C20H17F3N2O4. Mole weight: 406.361. | |
| TAT 14 | TAT 14. Group: Biochemicals. Grades: Purified. CAS No. 1362661-34-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TAT 14 | TAT 14 is an Nrf2 activator and inhibits Nrf2/Keap1 interaction with neuroprotective activity. TAT 14 has been shown to induce upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1 and suppress LPS-induced TNF-α expression in THP-1 cells. Synonyms: TAT14; TAT-14; H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-leucyl-L-glutaminyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-threonyl-glycyl-L-alpha-glutamyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-glutamine; TAT 14 Peptide (Nrf2 Activator III). Grades: ≥95%. CAS No. 1362661-34-4. Molecular formula: C137H230N48O39. Mole weight: 3173.59. | |
| TAT-14 | TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 [1]. Uses: Scientific research. Group: Peptides. CAS No. 1362661-34-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1328. | |
| TAT (47-57), FAM-labeled | It is a fluorescent (FAM) labeled TAT peptide, Abs/Em=494/521 nm. TAT is the most characteristic fragment of HIV trans-activator protein (TAT). The arginine-rich TAT peptide penetrates the plasma membrane directly rather than through endocytosis. Synonyms: FAM-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; N-[(3',6'-Dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl)carbonyl]-L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine; 5-FAM-HIV-1 Tat Protein (47-57). Grades: ≥95%. CAS No. 1676104-81-6. Molecular formula: C85H128N32O20. Mole weight: 1918.16. | |
| TAT (47-57) GGG-Cys(Npys) | It corresponds to the protein transduction domain of the TAT protein and is synthesized with an activated cysteine residue C(Npys), where Npys is 3-Nitro-2-pyridinesulfenyl group and is used for activating S of cysteine and for rapid reaction when a thiol group is introduced. The N-terminus is rendered free for applications requiring certain conjugation reactions with a free N-terminal end, and a linker GGG is placed at the C-terminal end, and the peptide has been synthesized with the C(Npys) group. This kind of modification has been used to render this peptide as a cell penetrating and carrier peptide applicable in conjugation studies. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Cys(Npys)-NH2. Grades: ≥95%. Molecular formula: C78H135N39O19S2. Mole weight: 1987.29. | |
| TAT (47-57), TAMRA-labeled | It is a fluorescent (TAMRA)-labeled TAT peptide, Abs/Em=541/568 nm. TAT is the most characteristic fragment of HIV trans-activator protein (TAT). The arginine-rich TAT peptide penetrates the plasma membrane directly rather than through endocytosis. Synonyms: TAMRA-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH. Grades: ≥95%. | |
| Tatarinoid A | Phenylpropanoids. CAS No. 1229005-35-9. Molecular formula: C12H16O5. Mole weight: 240.3. Appearance: Powder. Purity: 0.98. IUPACName: (2R)-2-hydroxy-1-(2,4,5-trimethoxyphenyl)propan-1-one. Canonical SMILES: CC(C(=O)C1=CC(=C(C=C1OC)OC)OC)O. Catalog: ACM1229005359. | |
| Tat-beclin 1 | Tat-beclin 1 is a region of the autophagy protein, beclin 1, binding to HIV-1 Nef and inducing autophagy. Synonyms: Tat-BECN1. CAS No. 1423821-88-8. Molecular formula: C164H251N57O45. Mole weight: 3741.1. | |
| Tat-Beclin-1 | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that triggers cell adaptation, survival, or death. When combined with the cell-permeable peptide, it can successfully enter cells and induce autophagy. Synonyms: Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH; Tat-BECN1. Grades: ≥95%. Molecular formula: C164H251N57O45. Mole weight: 3741.15. | |
| Tat-Beclin-1, scrambled | Beclin-1 peptide is the HIV-1 Nef binding portion of full-length human Beclin-1 protein (amino acids 267-299). Beclin-1 protein is an autophagy inducing agent that triggers cell adaptation, survival, or death. When combined with the cell-permeable peptide, it can successfully enter cells and induce autophagy. Tat-Beclin-1, scrambled will not induce autophagy and can be used as a negative control. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Val-Gly-Asn-Asp-Phe-Phe-Ile-Asn-His-Glu-Thr-Thr-Gly-Phe-Ala-Thr-Glu-Trp-OH. Grades: ≥95% by HPLC. Molecular formula: C164H251N57O45. Mole weight: 3741.15. | |
| TAT-C (48-57) | It is amino acids 48 to 57 fragment of TAT with an additional cysteine residue at the N-terminus. The peptide contains a protein transduction domain (PTD) that inhibits HSV-1 entry into the HIV Tat protein. The addition of cysteine residue to the N-terminus of the Tat-PTD (Tat-C peptide) improves the antiviral activity against HSV-1 and HSV-2. Tat-C acts extracellular and immediately blocks the entry of adsorptive virus without eluting virions. Synonyms: H-Cys-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH; (Cys47)-HIV-1 tat Protein (47-57); L-cysteinyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginine. Grades: ≥95%. CAS No. 627079-23-6. Molecular formula: C58H114N32O13S. Mole weight: 1499.82. | |
| TAT-cyclo-CLLFVY | TAT-cyclo-CLLFVY is a cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. TAT-cyclo-CLLFVY disrupts HIF-1α/HIF-1β protein-protein interaction with an IC 50 of 1.3 μM [1]. Uses: Scientific research. Group: Peptides. CAS No. 1446322-66-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1420. | |
| TAT-cyclo-CLLFVY | TAT-cyclo-CLLFVY has been found to be a HIF-1 dimerization inhibitor and could block protein-protein interaction of recombinant HIF-1&alpha. Synonyms: TAT-cyclo-CLLFVY; 1446322-66-2; AKOS027470216; PD079835. Grades: ≥95% by HPLC. CAS No. 1446322-66-2. Molecular formula: C111H188N42O24S2. Mole weight: 2559.10. | |
| TAT-Gap19 | TAT-Gap19 is a brain penetrating Cx43 hemichannel blocker (IC50 ~7 μM) with no significant affinity for gap junctions or Panx1 channels. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-alpha-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-lysine. Grades: 97%. CAS No. 1507930-54-2. Molecular formula: C119H212N46O26. Mole weight: 2703.28. | |
| TAT-GluA2 3Y acetate | TAT-GluA2 3Y acetate is a cell-penetrating peptide containing tyrosine residues. It inhibits the phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH.CH3CO2H; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-alpha-glutamyl-glycyl-L-tyrosyl-L-asparagyl-L-valyl-L-tyrosyl-glycine acetic acid. Grades: ≥95%. Molecular formula: C117H189N43O31. Mole weight: 2694.07. | |
| TAT-GluR23A Fusion Peptide | TAT-GluR23A Fusion Peptide is a control inactive peptide that acts as a mutant counterpart to glutamate receptor endocytosis inhibitor (GluR23Y), linked to an 11 amino acid cell permeable HIV Trans-activator of Transcription (TAT) protein transduction domain (PTD). GluR23A is derived from GluR23Y amino acid 869-877, which is substituted for Tyr by Ala and lacks necessary phosphorylation sites. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Lys-Glu-Gly-Ala-Asn-Val-Ala-Gly-OH. Grades: ≥95%. Molecular formula: C97H173N43O26. Mole weight: 2357.71. | |
| TAT-GluR23Y | TAT-GluR23Y is a cell penetrating peptide containing tyrosine residues. It inhibits the phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH; Tat-GluR23Y; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-alpha-glutamyl-glycyl-L-tyrosyl-L-asparagyl-L-valyl-L-tyrosyl-glycine; TAT-GluA2 3Y. Grades: ≥95%. CAS No. 1404188-93-7. Molecular formula: C115H185N43O29. Mole weight: 2634.01. | |
| TAT-GluR23Y, scrambled | TAT-GluR23Y, scrambled is a control peptide. The synthetic peptide (Tat-Glur23Y), containing tyrosine residues, blocks phosphorylation of AMPA receptor endocytosis. However, the scrambled version does not have blockade properties. Previous studies show that Tat-Glur23Y, scrambled increases stress levels in mice, while Tat-Glur23Y reduces stress when administered. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Val-Tyr-Lys-Tyr-Gly-Gly-Tyr-Asn-Glu-OH; Tat-GluR23Y, scrambled. Grades: ≥95%. Molecular formula: C115H185N43O29. Mole weight: 2634.01. | |
| TAT-HA2 Fusion Peptide | It is a cell penetrating peptide consisting of amino acids 1 to 20 of influenza A virus hemagglutinin protein (HA2), which is linked to a 10 amino acid cell permeable HIV Trans-activator of Transcription (TAT) protein transduction domain (PTD). TAT-HA2 can be used as a large molecule drug delivery peptide. TAT PTD binds to the cell surface and penetrates the cell membrane through lipid raft dependent macropinocytosis. The HA2 domain is a pH-sensitive lipid membrane destabilizing sequence that enhances endosomal escape and transduction of the fusion peptide. Synonyms: H-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-Gly-Asp-Ile-Met-Gly-Glu-Trp-Gly-Asn-Glu-Ile-Phe-Gly-Ala-Ile-Ala-Gly-Phe-Leu-Gly-OH. Grades: ≥95%. Molecular formula: C149H243N53O39S. Mole weight: 3432.98. | |
| TAT-NSF222 Fusion Peptide | This sequence is a N-ethylmaleimide sensitive factor (NSF) peptide that connects to the 11 amino acid cell permeable human immunodeficiency virus (HIV) transactivating regulatory protein (TAT) domain by Gly-Gly-Gly spacer. The peptide contains the NSF domain extending from 222 to 243 amino acids, which is located directly at the amino terminus of the Walker A motif in the NSF D1 domain. ATPase assay shows that TAT-NSF222 inhibits the activity of NSF ATPase. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Leu-Asp-Lys-Glu-Phe-Asn-Ser-Ile-Phe-Arg-Arg-Ala-Phe-Ala-Ser-Arg-Val-Phe-Pro-Pro-Glu-OH. Grades: ≥95%. Molecular formula: C187H301N67O47. Mole weight: 4239.89. | |
| TAT-NSF222scr Fusion Polypeptide, scrambled | It is a scrambled TAT-NSF222scr fusion polypeptide. It consists of 11 amino acids from the cell permeable human immunodeficiency virus TAT polypeptide, 3 glycines as a linker, followed by scrambled N-Ethyl-maleimide-sensitive factor (NSF) D1 domain. It is used as a control for the TAT-NSF222 peptide. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Glu-Asn-Ser-Phe-Arg-Phe-Leu-Ala-Asp-Ile-Phe-Pro-Ala-Lys-Ala-Phe-Pro-Val-Arg-Phe-Glu-OH. Grades: ≥95%. Molecular formula: C190H298N64O46. Mole weight: 4214.88. | |
| TAT-NSF700 Fusion Peptide | It is a N-Ethyl-maleimide-sensitive factor (NSF) inhibitor fusion polypeptide, which is fused from the 11 amino acid cell permeable HIV transactivation regulatory protein (TAT) domain to the 22 amino acid NSF domain. TAT-NSF700 inhibits thrombin-induced exocytosis of endothelial cells in a dose-responsive manner. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Leu-Leu-Asp-Tyr-Val-Pro-Ile-Gly-Pro-Arg-Phe-Ser-Asn-Leu-Val-Leu-Gln-Ala-Leu-Leu-Val-Leu-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-glycyl-glycyl-glycyl-L-leucyl-L-leucyl-L-alpha-aspartyl-L-tyrosyl-L-valyl-L-prolyl-L-isoleucyl-glycyl-L-prolyl-L-arginyl-L-phenylalanyl-L-seryl-L-asparagyl-L-leucyl-L-valyl-L-leucyl-L-glutaminyl-L-alanyl-L-leucyl-L-leucyl-L-valyl-L-leucine. Grades: ≥95%. Molecular formula: C188H318N62O45. Mole weight: 4167.00. | |
| TAT-NSF700scr | TAT-NSF700scr is used as a control peptide to TAT-NSF700 peptide. Compared with TAT-NSF700, it does not inhibit the disassembly activity of NSF, and TAT-NSF700 plays a key role in regulating exocytosis. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Ile-Pro-Pro-Val-Tyr-Phe-Ser-Arg-Leu-Asp-Leu-Asn-Leu-Val-Val-Leu-Leu-Leu-Ala-Gln-Leu-OH. Grades: ≥95%. Molecular formula: C186H315N61O44. Mole weight: 4109.95. | |
| TAT-NSF81scr Fusion Polypeptide, scrambled | It is a scrambled peptide containing the TAT domain and 20 of N-Ethyl-maleimide-sensitive factor 81 (NSF81). TAT-NSF81scr is used to measure the effect of the active and control peptides upon NSF activities and exocytosis. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Gly-Gln-Asp-Gly-Cys-Lys-Tyr-Phe-Ala-Thr-Asp-Glu-Thr-Ile-Met-Lys-Leu-Ser-Ile-Ala-Ile-OH. Grades: ≥97%. Molecular formula: C169H284N58O48S2. Mole weight: 3960.61. | |
| TAT P59W | It is a TAT peptide containing tryptophane residues. Synonyms: Fluo-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Trp-Gln-NH2. Grades: 98%. | |
| TAT peptide | TAT peptide, derived from the transactivator of transcription (TAT) of human immunodeficiency virus, is a cell penetrating peptide (GRKKRRQRRRPQ). Synonyms: TAT-peptide. Grades: 98%. Molecular formula: C65H124N34O15. Mole weight: 1621.91. | |
| TATU | TATU. Group: Biochemicals. Alternative Names: 1-[Bis (dimethylamino) methylene]-1H-1, 2, 3-triazolo[4, 5-b]pyridinium 3-oxide tetrafluoroborate; O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate. Grades: Highly Purified. CAS No. 873798-09-5,873678-56-9. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C10H15N6OBF4. US Biological Life Sciences. | Worldwide |
| TATU | Synonyms: O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 2-(3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; O-(7-Azabenzotriazolyl)-tetramethyluronium tetrafluoroborate; TATU [O-(7-Azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate]; ACMC-209vlk; SCHEMBL153586. Grades: 99% (HPLC). CAS No. 873798-09-5. Molecular formula: C10H16BF4N6O. Mole weight: 323.08. | |
| Taunomycin acid | Taunomycin acid. Uses: For analytical and research use. Group: Impurity standards. CAS No. 25696-60-0. Molecular Formula: C26H45NO7S. Mole Weight: 515.71. Catalog: APB25696600. |  |
| Tau Peptide (1-16) (human) | Tau peptide (1-16) (human) corresponds to the N-terminus of the nascent Tau protein. Posttranslational modifications include removal of N-terminal Met and acetylation of Ala2. Synonyms: H-Met-Ala-Glu-Pro-Arg-Gln-Glu-Phe-Glu-Val-Met-Glu-Asp-Met-Ala-Gly-OH. Grades: ≥95%. CAS No. 2022956-53-0. Molecular formula: C77H120N20O28S3. Mole weight: 1870.12. | |
| Tau Peptide (244-274) (Repeat 1 Domain) | During heparin-induced self-aggregation of the four repeat domain peptides (R1-R4) excised from tau, R1, which is similar to the Tau peptide (244-274), shows the strongest resistance to filament formation. Its conformation remains the same. It maintains the same random structure under acidic and neutral conditions. Synonyms: H-Gln-Thr-Ala-Pro-Val-Pro-Met-Pro-Asp-Leu-Lys-Asn-Val-Lys-Ser-Lys-Ile-Gly-Ser-Thr-Glu-Asn-Leu-Lys-His-Gln-Pro-Gly-Gly-Gly-Lys-OH; L-Glutaminyl-L-threonyl-L-alanyl-L-prolyl-L-valyl-L-prolyl-L-methionyl-L-prolyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-asparaginyl-L-valyl-L-lysyl-L-seryl-L-lysyl-L-isoleucylglycyl-L-seryl-L-threonyl-L-alpha-glutamyl-L-asparaginyl-L-leucyl-L-lysyl-L-histidyl-L-glutaminyl-L-prolylglycylglycylglycyl-L-lysine. Grades: ≥95%. CAS No. 330456-24-1. Molecular formula: C141H238N42O44S. Mole weight: 3257.63. | |
| Tau Peptide (245-274) (Repeat 1 Domain) | Synonyms: H-Thr-Ala-Pro-Val-Pro-Met-Pro-Asp-Leu-Lys-Asn-Val-Lys-Ser-Lys-Ile-Gly-Ser-Thr-Glu-Asn-Leu-Lys-His-Gln-Pro-Gly-Gly-Gly-Lys-OH; L-threonyl-L-alanyl-L-prolyl-L-valyl-L-prolyl-L-methionyl-L-prolyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-asparagyl-L-valyl-L-lysyl-L-seryl-L-lysyl-L-isoleucyl-glycyl-L-seryl-L-threonyl-L-alpha-glutamyl-L-asparagyl-L-leucyl-L-lysyl-L-histidyl-L-glutaminyl-L-prolyl-glycyl-glycyl-glycyl-L-lysine. Grades: ≥95%. CAS No. 1428134-39-7. Molecular formula: C136H230N40O42S. Mole weight: 3129.63. | |
| Tau Peptide (255-314) (Repeat 2 Domain) (human) | Synonyms: H-Asn-Val-Lys-Ser-Lys-Ile-Gly-Ser-Thr-Glu-Asn-Leu-Lys-His-Gln-Pro-Gly-Gly-Gly-Lys-Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-Ser-Asn-Val-Gln-Ser-Lys-Cys-Gly-Ser-Lys-Asp-Asn-Ile-Lys-His-Val-Pro-Gly-Gly-Gly-Ser-Val-Gln-Ile-Val-Tyr-Lys-Pro-Val-Asp-OH. Grades: ≥95%. CAS No. 2022995-68-0. Molecular formula: C277H467N83O86S. Mole weight: 6368.33. | |
| Tau Peptide (268-282) | Synonyms: H-His-Gln-Pro-Gly-Gly-Gly-Lys-Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-OH; L-Histidyl-L-glutaminyl-L-prolylglycylglycylglycyl-L-lysyl-L-valyl-L-glutaminyl-L-isoleucyl-L-isoleucyl-L-asparaginyl-L-lysyl-L-lysyl-L-leucine. Grades: ≥95%. CAS No. 330456-37-6. Molecular formula: C72H125N23O19. Mole weight: 1616.93. | |
| Tau Peptide (273-284) | Tau Peptide (273-284), a Tau fragment containing the PHF6 region, plays a central role in Tau aggregation. Synonyms: H-Gly-Lys-Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-OH; glycyl-L-lysyl-L-valyl-L-glutaminyl-L-isoleucyl-L-isoleucyl-L-asparagyl-L-lysyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucine. Grades: ≥95%. CAS No. 1663490-91-2. Molecular formula: C62H113N17O17. Mole weight: 1368.68. | |
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