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| Product | Description | |
|---|---|---|
| Ultraviolet Absorbent UV-P | Drometrizole is a member of triazoles. Alternative Names: (2'-Hydroxy-5mg-methylphenyl) benzotriazole; 2-(2'-hydroxy-5-methyl; 2-(2H-1,2,3-Benzotriazol-2-yl)-4-methylphenol; 2-(2h-benzotriazol-2-yl)-4-methyl-pheno; 2-(2h-benzotriazol-2-yl)-p-creso; 2-(2-hydroxy-5-methyl-phenyl)-2H-benzotriazole. CAS No. 2440-22-4. Molecular formula: C13H11N3O. Mole weight: 225.25. |  |
| Ultraviolet absorbent UV-T | 2-Phenyl-5-benzimidazolesulfonic acid was used for the fabrication of biomimetic sensor for determination of 4-methylbenzylidene camphor (4-MBC), an ultraviolet (UV) radiation protector. Alternative Names: PARSOL HS; NEO HELIOPAN HYDRO; PHENYLBENZIMIDAZOLE SULFONIC ACID; LABOTEST-BB LT00454150; EUSOLEX 232; 2-PHENYL-1H-BENZOIMIDAZOLE-5-SULFONIC ACID. Grades: 95%. CAS No. 27503-81-7. Molecular formula: C13H10N2O3S. Mole weight: 274.29. | |
| Ultrazur ® | Ultrazur ®. CAS No. MIXTURE. VIGON Item # 502682. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. |  America & Internationally |
| Ulva lactuca extract | Ulva lactuca extract. Grades: 95%. CAS No. 97281-59-9. | |
| Ulvan polysaccharide | Ulvan polysaccharide is derived from Ulva lactuca, a green seaweed. This naturally occurring polysaccharide showcases a diverse range of pharmacological attributes used for studying diseases entrenched in oxidative stress, most notably cancer and cardiovascular complications. Alternative Names: Sulfated xylorhamnoglucuronan; Ulva; Ulvans. CAS No. 164252-34-0. Molecular formula: (C6H9O3SO3)n. | |
| Ulvan - Ulva rotondata-Autumn | Ulvan - Ulva rotondata-Autumn, originating from the autumnal Ulva rotondata, showcases great application in studying a multitude of ailments, encompassing cancer, diabetes and cardiovascular maladies alike. Alternative Names: Sulfated xylorhamnoglycuronan; Ulvan MW. Molecular formula: (C6H9O3SO3)n. | |
| Ulvan - Ulva rotondata-Summer | Ulvan, derived from the Ulva rotondata-Summer algae, is a remarkable natural polysaccharide. This bioactive compound exhibits immense application as a compound owing to its multifaceted anti-inflammatory and antioxidant characteristics. Alternative Names: Sulfated xylorhamnoglycuronan; Ulvan MW. Molecular formula: (C6H9O3SO3)n. | |
| Ulviprubart | Ulviprubart (ABC-008) is a monoclonal antibody targeting the KLRG1 receptor that selectively depletes highly differentiated cytotoxic T cells. Ulviprubart can be used in the study of inclusion body myositis (IBM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABC-008. CAS No. 2569434-60-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990026. |  |
| UMB298 | UMB298 is a potent and selective CBP/P300 bromodomain inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2266569-73-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139148. | |
| UMB-32 | UMB-32, a potent, selective BRD4 inhibitor, binds BRD4 with the Kd of 550 nM, and IC50 of 637 nM. UMB-32 also shows potency against TAF1, a bromodomain-containing transcription factor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1635437-39-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117997. | |
| Umbelliferone | Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects inchronic alcohol-fed rats[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Hydroxycoumarin; Hydrangin; NSC 19790. CAS No. 93-35-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N0573. | |
| Umbelliferone-d5 | Umbelliferone-d5 (7-Hydroxycoumarin-d5) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Hydroxycoumarin-d5; Hydrangin-d5; NSC 19790-d5. CAS No. 1215373-23-1. Pack Sizes: 2.5 mg. Product ID: HY-N0573S. | |
| Umbellulone | Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 546-78-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-135013. | |
| Umbilicaric acid | Umbilicaric acid is an organic polyphenolic carboxylic acid. CAS No. 30666-92-3. Molecular formula: C25H22O10. Mole weight: 482.44. | |
| Umbralisib | Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TGR-1202; RP5264. CAS No. 1532533-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279. | |
| Umbralisib | Umbralisib (TGR 1202) is a PI3Kδ inhibitor. Category: Active pharmaceutical ingredients. CAS No. 1532533-67-7. Product ID: API1532533677. Molecular formula: C31H24F3N5O3. Mole weight: 571.55. |  |
| Umbralisib | Umbralisib is an orally bioavailable and selective PI3K delta inhibitor that targets delta isoform with nanomolar potency, which is approximately 1000-fold selective over alpha isoform, >30-50 fold over beta isoform and >15-50 fold over gamma isoforms. Umbralisib is developed for lymphoma therapy. Alternative Names: TGR-1202; TGR 1202; TGR1202; RP5264; 2-[(1S)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one. CAS No. 1532533-67-7. Molecular formula: C31H24F3N5O3. Mole weight: 571.5. | |
| Umbralisib hydrochloride | Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TGR-1202 hydrochloride; RP5264 hydrochloride. CAS No. 1532533-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279C. | |
| Umbralisib hydrochloride | Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε (EC50: 6.0 μM). Category: Active pharmaceutical ingredients. Synonyms: RP5264 hydrochloride, TGR-1202 hydrochloride. CAS No. 1532533-78-0. Product ID: API1532533780. Molecular formula: C31H25ClF3N5O3. Mole weight: 608.01. | |
| Umbralisib R-enantiomer | Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against δPI3 kinase is at least 20 times lower than that of the inhibitors against other PI3K isoforms (A, β, and γ). Category: Active pharmaceutical ingredients. CAS No. 1532533-69-9. Product ID: API1532533699. Molecular formula: C31H24F3N5O3. Mole weight: 571.55. | |
| Umbralisib sulfate | Umbralisib (TGR-1202) sulfate, an orally active compound, serves as a potent, selective inhibitor targeting both PI3Kδ and casein kinase-1-ε (CK1ε), with EC50 values of 22.2 nM and 6.0 μM, respectively. It demonstrates unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL) and is applicable in the research of hematological malignancies. Category: Active pharmaceutical ingredients. Synonyms: TGR-1202 sulfate; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate. CAS No. 1532533-75-7. Product ID: API1532533757. Molecular formula: C31H26F3N5O7S. Mole weight: 669.63. | |
| Umbralisib tosylate | Umbralisib Tosylate (TGR-1202) is a potent, selectively dual inhibitor targeting PI3Kδ and casein kinase-1-ε (CK1ε), demonstrating oral activity. With EC50 values of 22.2 nM and 6.0 μM for PI3Kδ and CK1ε respectively, it shows unique immunomodulatory effects on T cells in chronic lymphocytic leukemia (CLL). This compound is utilized in the research of hematological malignancies. Category: Active pharmaceutical ingredients. Synonyms: RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate. CAS No. 1532533-72-4. Product ID: API1532533724. Molecular formula: C38H32F3N5O6S. Mole weight: 743.75. | |
| Umeclidinium bromide | Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD). Alternative Names: GSK-573719, GSK573719, GSK 573719, GSK-573719A, GSK573719A, GSK 573719A, Incruse Ellipta, Umeclidinium bromide. Grades: 0.99. CAS No. 869113-09-7. Molecular formula: C29H34BrNO2. Mole weight: 508.5. | |
| Umeclidinium bromide | Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK573719A. CAS No. 869113-09-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12100. | |
| UMI-77 | UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members. Uses: Scientific research. Category: Signaling pathways. CAS No. 518303-20-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18628. | |
| UMI-77 | UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. Alternative Names: UMI-77, UMI77, UMI 77. Grades: >98%. CAS No. 518303-20-3. Molecular formula: C18H14BrNO5S2. Mole weight: 468.34. | |
| Umibecestat | Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively[1]. Umibecestat can be used for the research of alzheimer's disease. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNP520. CAS No. 1387560-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119689. | |
| Umifenovir | Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 131707-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14904. | |
| Umifenovir hydrochloride (Standard) | Umifenovir (hydrochloride) (Standard) is the analytical standard of Umifenovir (hydrochloride). This product is intended for research and analytical applications. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 131707-23-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14904AR. | |
| Umifoxolaner | Umifoxolaner (ML-878), a γ-aminobutyric acid (GABA) regulated chloride channels antagonist, is a potent insecticide, and acaricide. Umifoxolaner can be uesd for parasite infection research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML-878. CAS No. 2021230-37-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-139587. | |
| Umirolimus | A semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group. It is one of the most hydrophobic tacrolimus analogues. It binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Alternative Names: Biolimus; Biolimus A9; TRM 986; 42-O-(2-Ethoxyethyl)rapamycin. Grades: >95% by HPLC. CAS No. 851536-75-9. Molecular formula: C55H87NO14. Mole weight: 986.28. | |
| Umirolimus | Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 851536-75-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122402. | |
| UMK57 | UMK57 is a MCAK activator and kinetochore-microtubule destabilizer. UMK57 enhances MCAK-dependent microtubule depolymerization, increases kinetochore-microtubule turnover, reduces chromosome mis-segregation and lagging chromosomes, and inhibits cancer cell proliferation. UMK57 triggers adaptive resistance in Aurora B cancer cells via reversible Aurora B signaling pathway alterations. UMK57 can be used for the research of solid tumors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 342595-74-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122236. | |
| UMP/CMP kinase | This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase. Group: Enzymes. Synonyms: cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Enzyme Commission Number: EC 2.7.4.14. CAS No. 37278-21-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3195; UMP/CMP kinase; EC 2.7.4.14; 37278-21-0; cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Cat No: EXWM-3195. |  |
| UMP-CP | UMP-CP is a non-hydrolytic analogue of UDP and a starting structure in the synthesis of α/β hydrolysis-resistant tri- and polyphosphates. Alternative Names: Uridine- 5'- O- (α, β- methylene)diphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 732921-73-2. Molecular formula: C10H16N2O11P2 (free acid). Mole weight: 402.2 (free acid). | |
| UMP kinase | This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP. Group: Enzymes. Synonyms: uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA. Enzyme Commission Number: EC 2.7.4.22. CAS No. 9036-23-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3204; UMP kinase; EC 2.7.4.22; 9036-23-1; uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA. Cat No: EXWM-3204. | |
| UN6HA1 60L | 1ea Pack Size. Group: Equipment. Prepack ID 90027219-1ea. See USA prepack pricing. |  |
| UNA-A(Bz)-CE Phosphoramidite | UNA-A(Bz)-CE Phosphoramidite is an advanced biomedical compound used for the research of cancer, including breast and lung cancer. It acts by targeting specific cellular pathways involved in cancer progression, inhibiting tumor growth and promoting cell death. Alternative Names: N6-Benzoyl-(5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2R)-2-[(1R)-1-[6-(benzoylamino)-9H-purin-9-yl]-2-(benzoyloxy)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2R)-2-[(1R)-1-[6-(Benzoylamino)-9H-purin-9-yl]-2-(benzoyloxy)ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite. Grades: ≥98% by HPLC. CAS No. 1120329-52-3. Molecular formula: C54H58N7O9P. Mole weight: 980.06. | |
| UNA-C | UNA-C is a synthetic unlocked cytidine nucleobase analog that is used as a building block in the synthesis of unlocked DNA and RNA molecules. Alternative Names: (R)-4-amino-1-(1-((1,3-dihydroxypropan-2-yl)oxy)-2-hydroxyethyl)pyrimidin-2(1H)-one; UNA cytidine; (R)-4-Amino-1-[2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-2(1H)-pyrimidinone; 2',3'-Seco-cytidine; Seco-C; 2(1H)-Pyrimidinone, 4-amino-1-[(1R)-2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-; 2(1H)-Pyrimidinone, 4-amino-1-[2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-, (R)-; 4-Amino-1-[(1R)-2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-2(1H)-pyrimidinone; Cytosine, 1-[2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-, (R)-. CAS No. 29847-37-8. Molecular formula: C9H15N3O5. Mole weight: 245.23. | |
| UNA-G(iBu)-CE Phosphoramidite | UNA-G(iBu)-CE Phosphoramidite is a uniquely intricate compound possessing potential applications in the realm of cancer therapeutics. Possessing potent antineoplastic capabilities, it demonstrates high efficacy in the research of obstruction in malignant cellular proliferation. Alternative Names: N2-Isobutyryl-(5'-(4,4'-dimethoxytrityl)-2'-benzoyl-2',3'-seco-guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)] phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, (2R)-2-[(1R)-2-(benzoyloxy)-1-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl ester; (2R)-2-[(1R)-2-(Benzoyloxy)-1-[1,6-dihydro-2-[(2-methyl-1-oxopropyl)amino]-6-oxo-9H-purin-9-yl]ethoxy]-3-[bis(4-methoxyphenyl)phenylmethoxy]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite. Grades: ≥98% by HPLC. CAS No. 1120329-61-4. Molecular formula: C51H60N7O10P. Mole weight: 962.04. | |
| Unasnemab | Unasnemab (MT-3921) is a humanised IgG1 monoclonal antibody that binds to repulsive guidance molecule A (RGMa). Unasnemab improves locomotor function and promotes neuroregeneration. Unasnemab exerts ameliorative effects on hippocampal neurogenesis impairment and cognitive decline in db/db mice, Streptozotocin (STZ) (HY-13753)-induced type 1 diabetic and bilateral common carotid artery stenosis (BCAS)-induced mice. Unasnemab can be used for the research of spinal cord injury, diabetes-induced neurological impairments[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MT-3921; rH116A3. CAS No. 2379805-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99959. | |
| UNA-T | UNA-T is a synthetic unlocked cytidine nucleobase analog that is used as a building block in the synthesis of unlocked DNA molecules. Alternative Names: (R)-1-(1-((1,3-dihydroxypropan-2-yl)oxy)ethyl)-5-methylpyrimidine-2,4(1H,3H)-dione; UNA-Thymidine; Seco-T; 2',3'-Seco-thymidine; 1-{(1R)-1-[(1,3-Dihydroxy-2-propanyl)oxy]ethyl}-5-methyl-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 1-[(1R)-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-5-methyl-. CAS No. 138239-71-1. Molecular formula: C10H16N2O5. Mole weight: 244.24. | |
| UNA-U | UNA-U is a synthetic unlocked cytidine nucleobase analog that is used as a building block in the synthesis of unlocked RNA molecules. Alternative Names: 2',3'-Seco-uridine; (R)-1-(1-((1,3-dihydroxypropan-2-yl)oxy)-2-hydroxyethyl)pyrimidine-2,4(1H,3H)-dione; 1-{(1R)-1-[(1,3-Dihydroxy-2-propanyl)oxy]-2-hydroxyethyl}-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 1-[(1R)-2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-; UNA-Uridine; Seco-U; 1-[(1R)-2-Hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-2,4(1H,3H)-pyrimidinedione; 2,4(1H,3H)-Pyrimidinedione, 1-[2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-, (R)-; Uracil, 1-[2-hydroxy-1-[2-hydroxy-1-(hydroxymethyl)ethoxy]ethyl]-, (R)-. CAS No. 29847-34-5. Molecular formula: C9H14N2O6. Mole weight: 246.22. | |
| UNC0224 | UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197196-48-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10929. | |
| UNC 0224 | UNC 0224. Group: Biochemicals. Grades: Purified. CAS No. 1197196-48-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| UNC0321 (TFA Salt) | UNC0321 (trifluoroacetate salt) is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP (also known as EHMT1), with IC50 of 6nM and 15nM, respectively. It is more than 40,000-fold more selective for G9a and GLP vs. SET7/9, SET8, PRMT3, or JMJD2E. Group: Biochemicals. Alternative Names: 4-Quinazolinamine, 7-[2-[2- (dimethylamino) ethoxy]ethoxy]-2- (hexahydro-4-methyl-1H-1, 4-diazepin-1-yl) -6-methoxy-N- (1-methyl-4-piperidinyl) -, trifluoroacetate. Grades: Highly Purified. CAS No. 1238673-32-9 (free base). Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620401-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-12335. | |
| UNC0379 trifluoroacetate | UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases. Alternative Names: UNC-0379 trifluoroacetate; UNC 0379 trifluoroacetate; UNC0379 trifluoroacetate. Grades: >98%. CAS No. 1620401-83-3. Molecular formula: C25H36F3N5O4. Mole weight: 527.58. | |
| UNC 0631 | UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC50 of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 25 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1320288-19-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13808. | |
| UNC0638 | UNC0638, a chemical probe, selectively inhibits G9a and GLP histone methyltransferases with IC50 of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1255580-76-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15273. | |
| UNC0638 | UNC0638 is a potent, selective and cell-penetrant chemical probe for G9a and GLP histone methyltransferase with IC50 of <15 nM and 19 nM, respectively, shows selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 has anti-viral activities. Group: Inhibitors. CAS No. 1255580-76-7. Pack Sizes: 10mg. Product ID: S8071. Formula: C30H47N5O2. Smiles: CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)C5CCCCC5. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| UNC-0638 | UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a variety of cell lines resulted in lower global H3K9me2 levels, equivalent to levels observed for small hairpin RNA knockdown of G9a and GLP with the functional potency of UNC0638 being well separated from its toxicity. UNC0638 markedly reduced the clonogenicity of MCF7 cells, reduced the abundance of H3K9me2 marks at promoters of known G9a-regulated endogenous genes and disproportionately affected several genomic loci encoding microRNAs. Alternative Names: UNC0638, UNC-0638, UNC 0638. Grades: 0.98. CAS No. 1255580-76-7. Molecular formula: C30H47N5O2. Mole weight: 509.739. | |
| UNC0642 | UNC0642, a chemical probe, is a potent and selective lysine methyltransferases G9a and GLP inhibitor, with an IC50 of <2.5 nM for G9a. Uses: Scientific research. Category: Signaling pathways. CAS No. 1481677-78-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13980. | |
| UNC0642 | UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a/GLP with IC50s less than 2.5 nM for G9a and GLP and shows more than 300-fold selective for G9a and GLP over a broad range of kinases, GPCRs, transporters, and ion channels. Group: Inhibitors. CAS No. 1481677-78-4. Pack Sizes: 5mg. Product ID: S7230. Formula: C29H44F2N6O2. Smiles: CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| UNC0646 | UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC50 of 6 nM. UNC0646 is also a potent GLP inhibitor (IC50 <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 26 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1320288-17-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13807. | |
| UNC 0646 | UNC 0646. Group: Biochemicals. Grades: Purified. CAS No. 1320288-17-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| UNC10142 | UNC10142 (Compound 44) is a first-in-class small molecule antagonist of CHD1 that binds with an IC50 value of 1.7 μM. UNC10142 leads to a dose-dependent reduction in viability in PTEN-deficient prostate cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3118919-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159989. | |
| UNC10201652 | UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 372495-52-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148044. | |
| UNC10217938A | UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. UNC10217938A enhances oligonucleotides effects by modulating their intracellular trafficking and release from endosomes. UNC10217938A also enhances the effects of antisense and siRNA oligonucleotides[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1347749-97-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136151. | |
| UNC1215 | UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. Alternative Names: UNC1215, UNC-1215, UNC 1215; (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone). Grades: >98%. CAS No. 1415800-43-9. Molecular formula: C32H43N5O2. Mole weight: 529.729. | |
| UNC1999 | UNC1999, a chemical probe, is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC50s of <10 nM and 45 nM, repectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1431612-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15646. | |
| UNC-1999 | UNC1999, the first orally bioavailable inhibitor that has high in vitro potency for wildtype and mutant EZH2 as well as EZH1. UNC1999 was highly selective for EZH2 and EZH1 over a broad range of epigenetic and non-epigenetic targets. UNC1999 was orally bioavailable in mice, making this inhibitor a valuable tool for investigating the role of EZH2 and EZH1 in chronic animal studies. UNC-1999 represents a useful tools for the biomedical community to investigate the role of EZH2 and EZH1 in health and disease. Alternative Names: UNC1999; UNC 1999; UNC-1999. Grades: 0.98. CAS No. 1431612-23-5. Molecular formula: C33H43N7O2. Mole weight: 569.754. | |
| UNC2025 | UNC2025 is a potent, ATP-competitive, highly orally active and BBB-permeable Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1429881-91-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12344. | |
| UNC-2025 | UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. Alternative Names: Cyclohexanol, 4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-; trans-4-[2-(Butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol; MRX 6313; UNC 2025; UNC2025. Grades: ≥95%. CAS No. 1429881-91-3. Molecular formula: C28H40N6O. Mole weight: 476.66. | |
| UNC-2025 hydrochloride | UNC-2025 hydrochloride is the hydrochloride salt of UNC-2025, which is the Mer/FLT3 dual inhibitor. Alternative Names: UNC-2025 hydrochloride; UNC 2025 hydrochloride; UNC2025 hydrochloride; (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol hydrochloride. Grades: >98%. CAS No. 2070015-17-5. Molecular formula: C28H41ClN6O. Mole weight: 513.12. | |
| UNC2025 hydrochloride | UNC2025 hydrochloride is a potent, ATP-competitive, highly orally active and BBB-permeable Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 hydrochloride exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070015-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12344A. | |
| UNC2250 | UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer. Alternative Names: UNC-2250; UNC 2250. Grades: 98%. CAS No. 1493694-70-4. Molecular formula: C24H36N6O2. Mole weight: 440.58. | |
| UNC 2327 | UNC 2327. Group: Biochemicals. Grades: Purified. CAS No. 1426152-53-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| UNC2383 | UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs). UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2123481-48-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157261. | |
| UNC2400 | UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1433200-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12845. | |
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