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| Product | Description | |
|---|---|---|
| AEG 3482 | AEG 3482 has been found to be an inhibitor of c-jun N-terminal kinase (JNK) signaling and could probably be useful against some neurological disorders. Synonyms: AEG-3482; AEG 3482; AEG3482; 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide. Grade: ≥99% by HPLC. CAS No. 63735-71-7. Molecular formula: C10H8N4O2S2. Mole weight: 280.33. |  |
| AEG 3482 | AEG 3482. Group: Biochemicals. Grades: Purified. CAS No. 63735-71-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| AEG 40730 dihydrochloride | The dihydrochloride salt form of AEG 40730, which has been found to be an IAP antagonist as well as an apoptosis protein inhibitor and could probably be uesful in cancer research. Synonyms: AEG 40730 dihydrochloride; AEG40730 dihydrochloride; AEG-40730 dihydrochloride; 222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide, diethyl ether with 2,4-hexadiyne-1.6-diol dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1883545-50-3. Molecular formula: C52H68F6N8O8.2HCl. Mole weight: 1120.06. | |
| AEG 40730 dihydrochloride | AEG 40730 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AEG40826 | AEG40826 (HGS1029) is the hydrochloride salt of a small-molecule inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with potential antineoplastic activity. IAP inhibitor HGS1029 selectively inhibits the biological activity of IAP proteins, which may restore apoptotic signaling pathways; this agent may work synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. Synonyms: HGS-1029; HGS 1029; HGS1029; AEG40826-2HCl; AEG-40826; HGS1029; AEG 40826. Grade: 98%. CAS No. 1107664-44-7. | |
| Aegeline | Aegeline, is a compound that can be extracted from Aegle marmelos leaves, a tree that grows in India. Research has found the essential oil of the tree to be effective against 21 types of bacteria. Aegeline, has also shown to have anti-obesity effects. Synonyms: (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide; (E)-(±)-(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide. Grade: > 95%. CAS No. 456-12-2. Molecular formula: C18H19NO3. Mole weight: 297.36. | |
| Aegeline | Aegeline. Group: Biochemicals. Alternative Names: (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide; (E)-(±)-(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide; Egeline; (±)-Aegeline; (±)-Egeline; Aegelin. Grades: Highly Purified. CAS No. 456-12-2. Pack Sizes: 50mg. Molecular Formula: C18H19NO3, Molecular Weight: 297.35. US Biological Life Sciences. | Worldwide |
| Aegeline-d3 | Aegeline-d3. Group: Biochemicals. Alternative Names: (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide-d3; (E)-(±)-(2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenyl-2-propenamide-d3; Egeline-d3; (±)-Aegeline-d3; (±)-Egeline-d3; Aegelin-d3. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C18H16D3NO3, Molecular Weight: 300.37. US Biological Life Sciences. | Worldwide |
| Aegle marmelos leaf oil | Aegle marmelos leaf oil. Alternative Names: Aegle marmelos oil. CAS No. 977018-24-8. Product ID: FFC-AR-977018248. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Aeide-C1-NHS ester | Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Aeide-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 824426-32-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-140755. |  |
| AEM1 | AEM1 is a Nrf2 inhibitor. It decreases the expression of NRF2 controlled genes, sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo. Synonyms: N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine. Grade: >98%. CAS No. 1030123-90-0. Molecular formula: C20H14FN3O2S. Mole weight: 379.41. | |
| AEM1 | AEM1 is an Nrf2 inhibitor with anti-tumor and oral activity. AEM1 promotes the differentiation of HepaRG cells towards mature liver cells, aiding in the recovery of damaged liver[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1030123-90-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113848. | |
| AEOL-10150 pentachloride | AEOL-10150 pentachloride is a metalloporphyrin-catalyzed antioxidant and a superoxide dismutase mimetic. AEOL-10150 pentachloride scavenges ROS and RNS, and modulates the NF-κB signaling pathway. AEOL-10150 pentachloride has potent antioxidant and anti-inflammatory activities. AEOL-10150 pentachloride effectively mitigates tissue damage caused by radiation and chemical agents such as CEES (HY-W199190). AEOL-10150 pentachloride synergizes with radiotherapy to exert anticancer effects on prostate tumors[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 286475-30-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19416. | |
| AEP-IN-2 | AEP-IN-2 is an asparagine endopeptidase (AEP) inhibitor via block AEP cleavage of APP and Tau. AEP-IN-2 has oral activity and decreases Aβ40 and Aβ42 and p-Tau levels [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2565572-83-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153986. | |
| AER-271 | AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 634913-39-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115460. | |
| a-Ergocryptine | a-Ergocryptine. Group: Biochemicals. Alternative Names: 12'-Hydroxy-2'-(1-methylethyl)-5'-a-(2-methylpropyl)ergotaman-3',6',18-trione. Grades: Highly Purified. CAS No. 511-09-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C32H41N5O5. US Biological Life Sciences. | Worldwide |
| a-Ergocryptinine | a-Ergocryptinine. Group: Biochemicals. Alternative Names: Ergokryptinine; Isoergokryptine; a-Ergocryptinine. Grades: Highly Purified. CAS No. 511-10-4. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C32H41N5O5. US Biological Life Sciences. | Worldwide |
| Aerobactin | Akrabicin is a siderophore produced by the culture of Aerobacter aerogenes, Escherichia coli and Klebsiella pneumoniae under iron deficiency. Synonyms: Ferric-aerobactin; 3,9,15,21-Tetraazatricosane-8,12,16-tricarboxylic acid, 3,12,21-trihydroxy-2,10,14,22-tetraoxo-, [S-(R*,R*)]-. CAS No. 26198-65-2. Molecular formula: C22H36N4O13. Mole weight: 564.54. | |
| Aerobactin | Aerobactin is a siderophore produced by bacteria. Aerobactin is a highly potent pathogenic factor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26198-65-2. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-122280. | |
| aerobactin synthase | Requires Mg2+. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation. It is a dihydroxamate comprising two molecules of N6-acetyl-N6-hydroxy-L-lysine and one molecule of citric acid. This enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate. Group: Enzymes. Synonyms: iucC (gene name). Enzyme Commission Number: EC 6.3.2.39. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5756; aerobactin synthase; EC 6.3.2.39; iucC (gene name). Cat No: EXWM-5756. |  |
| aerobic carbon monoxide dehydrogenase | This enzyme, found in carboxydotrophic bacteria, catalyses the oxidation of CO to CO2 under aerobic conditions. The enzyme contains a binuclear Mo-Cu cluster in which the copper is ligated to a molybdopterin center via a sulfur bridge. The enzyme also contains two [2Fe-2S] clusters and FAD, and belongs to the xanthine oxidoreductase family. The CO2 that is produced is assimilated by the Calvin-Benson-Basham cycle, while the electrons are transferred to a quinone via the FAD site, and continue through the electron transfer chain to a dioxygen terminal acceptor. cf. EC 1.2.7.4, anaerobic carbon monoxide dehydrogenase. Group: Enzymes. Synonyms: MoCu-CODH; coxSML (gene names); molybdoenzyme carbon monoxide dehydrogenase. Enzyme Commission Number: EC 1.2.5.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1222; aerobic carbon monoxide dehydrogenase; EC 1.2.5.3; MoCu-CODH; coxSML (gene names); molybdoenzyme carbon monoxide dehydrogenase. Cat No: EXWM-1222. | |
| Aerocavin | Aerocavin is a macrolide antibiotic produced in Chromobacterium violaceum. Aerocavin has anti-Gram-positive bacteria and weak anti-negative bacteria activity. Synonyms: Oxacyclotetradeca-3,6,9-triene-4-acetic acid, 12-hydroxy-14-(2-hydroxyundecyl)-10-methyl-2-oxo-, (3E,6E,9E,12R*,14S*(R*))-(+)-; 2-[(3E,6Z,9Z,12R,14S)-12-hydroxy-14-[(2R)-2-hydroxyundecyl]-10-methyl-2-oxo-1-oxacyclotetradeca-3,6,9-trien-4-yl]acetic acid. CAS No. 113702-00-4. Molecular formula: C27H44O6. Mole weight: 464.63. | |
| Aerocyanidin | Aerocyanidin is an antibiotic produced in Chromobacterium violaceum. Aerocyanidin has strong anti-Gram-positive quotient activity, weak effect on negative bacteria. Synonyms: 11-(3-isocyano-3-methyloxiran-2-yl)undecaneperoxoic acid; kappa-Hydroxy-3-isocyano-3-methyloxiraneundecanoic acid (2-alpha(R*),3-alpha)-(-)-; Oxiraneundecanoic acid, kappa-hydroxy-3-isocyano-3-methyl-, (2-alpha(R*),3-alpha)-(-)-. Grade: >98%. CAS No. 113701-99-8. Molecular formula: C15H25NO4. Mole weight: 283.36. | |
| Aerosil 200 | Aerosil 200. Group: Biochemicals. Grades: Highly Purified. CAS No. 7631-86-9. Pack Sizes: 5kg, 10kg, 25kg. US Biological Life Sciences. | Worldwide |
| Aerosol 22 | Aerosol 22. CAS No. 38916-42-6. Product ID: ACM38916426. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Aerosol Monitor, Polystyrene 25 mm, mixed cellulose esters, 0.8 μm, white, with pad | Aerosol Monitor, Polystyrene 25 mm, mixed cellulose esters, 0.8 μm, white, with pad. |  |
| Aerothionin | Aerothionin is a dimeric spiroisoxazoline derived from marine sponges that demonstrates antimycobacterial activity. Synonyms: (+)-aerothionin. Grade: ≥97%. CAS No. 28714-26-3. Molecular formula: C24H26Br4N4O8. Mole weight: 818.1. | |
| Aeruginosin 865 | Aeruginosin 865 is isolated from terrestrial cyanobacterium Nostoc sp. Lukeová 30/93 with anti-inflammatory effect. It is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Grade: >98.0%. CAS No. 1611990-01-2. Molecular formula: C41H64N6O14. Mole weight: 864.98. | |
| AES-135 | AES-135 is a hydroxamic acid-based pan-HDAC inhibitor with IC50s ranging from 190-1100 nM for HDAC3, HDAC6, HDAC8 and HDAC11. It prolongs the survival in an orthotopic mouse model of pancreatic cancer. Synonyms: Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy-; 4-({N-[(4-Fluorophenyl)sulfonyl]-N-(pentafluorobenzyl)glycyl}[4-(2-methyl-2-propanyl)benzyl]amino)-N-hydroxybenzamide. Grade: ≥98%. CAS No. 2361659-61-0. Molecular formula: C33H29F6N3O5S. Mole weight: 693.66. | |
| AES-350 | AES-350 is an effective and orally active HDAC6 inhibitor with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 shows higher HDAC isoform selectivity, higher MV4-11 cell cytotoxicity, improved treatment window and more effective absorption through cells and lipid membranes. Synonyms: Tert-Butylbenzamido Hydroxylbenzamide. Grade: 98%. CAS No. 847249-57-4. Molecular formula: C18H20N2O3. Mole weight: 312.4. | |
| Aescin A | Aescin A. Group: Biochemicals. CAS No. 123748-68-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aescin B | Aescin B. Group: Biochemicals. CAS No. 26339-90-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aescin C | Aescin C. Group: Biochemicals. CAS No. 219944-39-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Aescine | Aescine. Alternative Names: AESCINE, 6805-41-0. CAS No. 6805-41-0. Molecular formula: C55H86O24. Mole weight: 1131.26. Purity: Purity >95%. IUPAC Name: 6-[[(4S,6aR,6bS,8aR,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-(2-methylbut-2-enoyloxy)-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-. SMILES: CC=C(C)C(=O)OC1C(C2(C(CC1(C)C)C3=CCC4C5(CCC(C(C5CCC4(C3(CC2O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(C(O7)CO)O)O)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CO)OC(=O)C. | |
| Aescin polysulphate sodium salt | Aescin polysulphate sodium salt is a remarkable biomedical compound with anti-inflammatory and antithrombotic prowess acting as an exquisite derivative of Aescin. Molecular formula: C53H82O36S4. Mole weight: 1423.46. | |
| Aestivophoenin A | Aestivophoenin is a nerve cell protective substance produced in Streptomyces purpeofuscus. Aestivophoenin A can reduce the toxicity of L-glutamate to Nl8-RE-105 cells, with an ECso of 15.0 nmol/L, and has an antioxidant effect. CAS No. 171864-91-8. Molecular formula: C31H32N2O7. Mole weight: 544.59. | |
| Aestivophoenin B | Aestivophoenin is a nerve cell protective substance produced in Streptomyces purpeofuscus. Aestivophoenin B can reduce the toxicity of L-glutamate to Nl8-RE-105 cells, with an ECso of 6.2 nmol/L, and has an antioxidant effect. CAS No. 171864-92-9. Molecular formula: C36H40N2O7. Mole weight: 612.71. | |
| a-Ethyl-N-formyl-N- methyl pyridinemethaneamine | a-Ethyl-N-formyl-N- methyl pyridinemethaneamine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Aetoxylon sympetalum oil | Aetoxylon sympetalum oil. CAS No. 1333524-00-7. Product ID: FFC-AR-1333524007. Alfa Chemistry - ISO 9001:32057 Certified. | |
| AEW-541 | AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. Synonyms: NVP-AEW541; NVP-AEW 541; NVP-AEW-541; AEW-541; AEW 541; AEW541. Grade: 0.98. CAS No. 475489-16-8. Molecular formula: C27H29N5O. Mole weight: 439.563. | |
| AEZS-108 | AEZS-108, also known as AN-152 or zoptarelin doxorubicin, is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation. Synonyms: AEZS 108; AEZS108; AN 152; AN-152; AN152; Zoptarelin doxorubicin; Zoptrex; Lys(6)-LHRH-doxorubicin. Grade: 98%. CAS No. 139570-93-7. Molecular formula: C91H117N19O26. Mole weight: 1893.01. | |
| AEZS-112 | AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cytotoxic effect was least pronounced in G2 phase of the cell cycle. AEZS 112 showed anti-tumor activity in human ovarian and endometrial cancer cell lines at low micromolar concns., which could not be abrogated by caspase inhibition and is therefore a good candidate for in vivo studies in these tumors. Synonyms: ZEN012; ZEN 012; ZEN-012; AEZS 112; AEZS112. Grade: 98%. CAS No. 1214741-69-1. Molecular formula: C25H23N3O2. Mole weight: 397.47. | |
| AF12198 | AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 μM) or the murine type I receptor (IC50>200 μM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 185413-30-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1110. | |
| AF 12198 | It is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-Leucinamide; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH2. Grade: >98%. CAS No. 185413-30-3. Molecular formula: C96H123N19O22. Mole weight: 1895.14. | |
| AF 12198 | AF 12198. Group: Biochemicals. Grades: Purified. CAS No. 185413-30-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AF 12198 acetate | AF 12198 acetate is a potent, selective human type I IL-1 receptor antagonist. Synonyms: N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate; Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2.CH3CO2H; (N-(N-acetyl-L-phenylalanyl-L-alpha-glutamyl-L-tryptophyl-L-threonyl-L-prolyl-glycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl)-(2S)-azetidine-2-carbonyl)-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-leucinamide acetate. Grade: ≥95%. Molecular formula: C98H127N19O24. Mole weight: 1955.17. | |
| AF3485 | AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC50s = 2.9 and >100 μM, respectively). Synonyms: CAY10686; N-[9-(2-hydroxyethyl)carbazol-3-yl]-2-(trifluoromethyl)benzamide. Grade: ≥95%. CAS No. 1195786-61-8. Molecular formula: C22H17F3N2O2. Mole weight: 398.4. | |
| AF 353 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Synonyms: AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine. Grade: >98%. CAS No. 865305-30-2. Molecular formula: C14H17IN4O2. Mole weight: 400.21. | |
| AF-353 | AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro-4. CAS No. 865305-30-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14483. | |
| AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353) | A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat; pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ flux and inward currents in nanomolar range (10nM to 1uM) in cell lines recombinantly expressing human P2X3 and P2X2/3 receptors. Exhibits desirable pharmacokinetic properties (t1/2 = 1.63 h and Tmax = 30 min). Group: Biochemicals. Grades: Highly Purified. CAS No. 927887-18-1. Pack Sizes: 5mg. Molecular Formula: C??H??ClIN?O?. US Biological Life Sciences. | Worldwide |
| AF38469 | AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1531634-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12802. | |
| AF38469 | AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor and shows no activity against the NTR1 receptor. Synonyms: AF 38469; AF-384694. CAS No. 1531634-31-7. Molecular formula: C15H11F3N2O3. Mole weight: 324.25. | |
| AF405 acid | AF405 acid is a fluorescent dye. AF405 exhibits a maximal excitation wavelength of 395 nm, and a maximal emission wavelength of 435 nm. AF405 is used for cell labeling and imaging[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852953-60-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D2445. | |
| AF488 NHS ester | AF488 NHS ester is an amine specific fluorescence probe (Em=525 nm). AF488 NHS ester reacts with sulfhydryl groups and amines in aqueous and biological samples then change their chemical structure and fluorescence properties after derivatization[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1374019-99-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D1730. | |
| AF615 | AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM). AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 122510-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-171180. | |
| AF64394 | AF64394 is a potent and selective GPR3 inverse agonist. Synonyms: AF 64394; AF-64394; N-(4-chloro-2-isopropoxybenzyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine. Grade: >98%. CAS No. 1637300-25-4. Molecular formula: C21H20ClN5O. Mole weight: 393.87. | |
| AF64394 | AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3. Uses: Scientific research. Category: Signaling pathways. CAS No. 1637300-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12664. | |
| AF647-NHS ester | AF647-NHS ester is an analog of Alexa Fluor 647 (AF647). NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). AF647 is a far-red fluorescent dye with an excitation wavelength (λex) of 635 nm (conventional fluorescence detection)/620 nm (instantaneous detection). Storage: Protect from light[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 407627-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-D1119. | |
| AF647-NHS ester triTEA | AF647-NHS ester is an analogue of Alexa Fluor 647 (AF647), which has excitation wavelength (λex) of 635 nm (conventional fluorescence detection)/620 nm (instantaneous detection). NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 407627-61-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D1119C. | |
| Afabicin | Afabicin is the prodrug of Debio1452 and an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Synonyms: Debio 1450; AFN-1720. CAS No. 1518800-35-5. Molecular formula: C23H24N3O7P. Mole weight: 485.43. | |
| Afacifenacin | Afacifenacin acts as a sodium/calcium exchanger inhibitor used in the prevention of reperfusion injury associated with restoration of coronary blood flow via surgery. Synonyms: (S)-(+)-3-[1-[3-(Trifluoromethoxy)benzyl]piperidin-4-yl]-4-phenyl-3,4-dihydro-1H-quinazolin-2-one. Grade: > 95%. CAS No. 877606-63-8. Molecular formula: C27H26F3N3O2. Mole weight: 481.52. | |
| A-factor | It is produced by the strain of streptomyces griseus. It can not only promote the formation of spores and air hyphae by streptomycin, but also restore the ability of non-production mutants to produce streptomycin, which is the so-called Autoregulator. Synonyms: 2-Isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone; Q27144309; SCHEMBL6026457; DTXSID00965600; 4-(HYDROXYMETHYL)-3-(6-METHYLHEPTANOYL)OXOLAN-2-ONE; 2(3H)-Furanone, dihydro-4-(hydroxymethyl)-3-(6-methyl-1-oxoheptyl)-, (4R)-; (-)-A factor; (R)-4-Hydroxymethyl-3-(6-methyl-heptanoyl)-dihydro-furan-2-one. CAS No. 51311-41-2. Molecular formula: C13H22O4. Mole weight: 242.31. | |
| Afamelanotide | Afamelanotide. Category: Active pharmaceutical ingredients. Grades: USDMF. CAS No. 75921-69-6. Product ID: API75921696. Molecular formula: C78H111N21O19. Mole weight: 1646.85. EINECS: 211-519-9. Standard: GMP. |  |
| Afasevikumab | Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG 7624; RO 5553110; NI-1401. CAS No. 1589503-30-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99424. | |
| Afatinib | Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIBW 2992. CAS No. 850140-72-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10261. | |
| Afatinib | Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Uses: Antineoplastic agents. Synonyms: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992; Gilotrif; Giotrif; Tovok; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grade: >98%. CAS No. 850140-72-6. Molecular formula: C24H25ClFN5O3. Mole weight: 485.94. | |
| Afatinib | Afatinib. Uses: For analytical and research use. Alternative Names: (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. CAS No. 850140-72-6. Molecular formula: C24H25ClFN5O3. Mole weight: 485.94. Catalog: APB850140726. |  |
| Afatinib (BIBW2992) | Afatinib inhibits EGFR / ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy. Group: Inhibitors. Alternative Names: BIBW2992. CAS No. 850140-72-6. Pack Sizes: 1g. Product ID: S1011. Formula: C24H25ClFN5O3. Smiles: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Afatinib-[d4] | Labelled Afatinib. Afatinib is a medication approved for the treatment of metastatic non-small cell lung cancer (NSCLC) that has certain EGFR mutations. It acts via inhibiting EGFR and HER2. Synonyms: (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992. Grade: > 98%. Molecular formula: C24H21D4ClFN5O3. Mole weight: 489.97. | |
| Afatinib-[d6] | Afatinib-[d6] is the labelled analogue of Afatinib. Afatinib is a medication approved for the treatment of metastatic non-small cell lung cancer (NSCLC) that has certain EGFR mutations. It acts via inhibiting EGFR and HER2. Synonyms: Afatinib-d6; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide-d6; BIBW 2992-d6; Tovok-d6; Tomtovok-d6. Grade: 97%; ≥99% atom D. CAS No. 1313874-96-2. Molecular formula: C24H19D6ClFN5O3. Mole weight: 491.98. | |
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