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| Product | Description | |
|---|---|---|
| aklanonic acid methyl ester cyclase | The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin. Group: Enzymes. Synonyms: dauD (gene name); aknH (gene name); dnrD (gene name); methyl aklanonate cyclase; methyl aklanonate-aklaviketone isomerase (cyclizing); aklaviketone lyase (decyclizing). Enzyme Commission Number: EC 5.5.1.23. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5624; aklanonic acid methyl ester cyclase; EC 5.5.1.23; dauD (gene name); aknH (gene name); dnrD (gene name); methyl aklanonate cyclase; methyl aklanonate-aklaviketone isomerase (cyclizing); aklaviketone lyase (decyclizing). Cat No: EXWM-5624. |  |
| aklanonic acid methyltransferase | The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin. Group: Enzymes. Synonyms: DauC; AAMT. Enzyme Commission Number: EC 2.1.1.288. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1895; aklanonic acid methyltransferase; EC 2.1.1.288; DauC; AAMT. Cat No: EXWM-1895. | |
| aklaviketone reductase | The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin. Group: Enzymes. Synonyms: dauE (gene name); aknU (gene name). Enzyme Commission Number: EC 1.1.1.362. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0279; aklaviketone reductase; EC 1.1.1.362; dauE (gene name); aknU (gene name). Cat No: EXWM-0279. | |
| Aklavin | It is produced by the strain of Streptomyces galilaeus. It has the activity of resisting gram positive bacterium, negative bacterium, candida and ringworm. Synonyms: Aclacinomycin T; 1-Deoxypyrromycin; Aclacinomycin; Doxypyrromycin; NSC 100290; CHEBI:74351; 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-((2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexapyranosyl)oxy)-, methyl ester, (1R-(1-alpha,2-beta,4-beta))-; aklavine. CAS No. 60504-57-6. Molecular formula: C30H35NO10. Mole weight: 569.60. |  |
| Aklavinone | Aklavinone is an anthracycline drug with an antitumor effect. CAS No. 16234-96-1. Molecular formula: C22H20O8. Mole weight: 412.39. | |
| aklavinone 12-hydroxylase | The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase. Group: Enzymes. Synonyms: DnrF; RdmE; aklavinone 11-hydroxylase (incorrect). Enzyme Commission Number: EC 1.14.13.180. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0779; aklavinone 12-hydroxylase; EC 1.14.13.180; DnrF; RdmE; aklavinone 11-hydroxylase (incorrect). Cat No: EXWM-0779. | |
| aklavinone 7-L-rhodosaminyltransferase | Isolated from the bacterium Streptomyces galilaeus. Forms a complex with its accessory protein AknT, and has very low activity in its absence. The enzyme can also use dTDP-2-deoxy-β-L-fucose. Involved in the biosynthesis of other aclacinomycins. Group: Enzymes. Synonyms: AknS/AknT; aklavinone 7-β-L-rhodosaminyltransferase; dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase. Enzyme Commission Number: EC 2.4.1.326. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2563; aklavinone 7-L-rhodosaminyltransferase; EC 2.4.1.326; AknS/AknT; aklavinone 7-β-L-rhodosaminyltransferase; dTDP-β-L-rhodosamine:aklavinone 7-α-L-rhodosaminyltransferase. Cat No: EXWM-2563. | |
| Aklomide | Aklomide is antiprotozoal agent against coccidiosis. Synonyms: 2-chloro-4-nitrobenzamide 2-Chloro-4-nitrobenzamide aklomide 3011-89-0 Aklomix Clomide Alkomide Benzamide, 2-chloro-4-nitro- component of Aklomix component of Novastat-W. CAS No. 3011-89-0. Molecular formula: C7H5ClN2O3. Mole weight: 200.58. | |
| AKN-028 | AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Synonyms: AKN 028; AKN028; N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine; 2,3-Pyrazinediamine, N3-1H-indol-5-yl-5-(4-pyridinyl)-; N3-(1H-Indol-5-yl)-5-(4-pyridinyl)-2,3-pyrazinediamine. Grade: ≥95%. CAS No. 1175017-90-9. Molecular formula: C17H14N6. Mole weight: 302.33. | |
| AKOS B018304 | AKOS B018304 is a potent inhibitor of chikungunya virus with low micromolar activity. Synonyms: (E)-2-Mercapto-5-(2-Nitrobenzylidene)Thiazol-4(5H)-One; O-Nitrobenzalrhodanin. Grade: 98%. CAS No. 6308-22-1. Molecular formula: C10H6N2O3S2. Mole weight: 266.3. | |
| AKR1B10-IN-1 | AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2136579-33-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139696. |  |
| AKR1C1 Inhibitor, 5-PBSA | A cell-permeable salicylic acid compound that acts as a highly potent, active-site directed and substrate competitive AKR1C1 inhibitor (Ki=4nM) with moderate to excellent selectivity over AKR1C2, AKR1C3 and AKR1C4 (Ki=0.087, 4.2 and 18.2uM, respectively). Shown to inhibit the metabolism of progesterone by AKR1C1 (IC50=460nM in AKR1C1 overexpressing BAECs).CAS No.4906-68-7. Group: Biochemicals. Alternative Names: Aldo-Keto Reductase family 1 member C1 Inhibitor, 5-PBSA, 3-Bromo-5-phenylsalicylic acid, 20α-Hydroxysteroid Dehydrogenase Inhibitor, 5-PBSA. Grades: Highly Purified. CAS No. 4906-68-7. Pack Sizes: 25mg. Molecular Formula: C??H?BrO?. US Biological Life Sciences. |  Worldwide |
| AKR1C3 Inhibitor (3- (4- (Trifluoromethyl) phenylamino) benzoic Acid) | A cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17b-hydroxysteroid dehydrogenase) (IC50 = 60nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50uM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100uM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Akrobomycin | It is produced by the strain of Actinomadura reseoviolacea 129-AVI. It has anti-gram-negative bacteria, ringworm and tumor activity. Synonyms: 9,10-Anhydro-13-deoxocarminomycin; 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-ethyl-9,10-dihydro-1,6,11-trihydroxy-, (S)-; DTXSID601008673; LS-94000; 3-Ethyl-5,10,12-trihydroxy-6,11-dioxo-1,2,6,11-tetrahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside; Akrobomycin; Rubomycin Q1. CAS No. 89156-94-5. Molecular formula: C26H27NO8. Mole weight: 481.49. | |
| Akt1 and Akt2-IN-1 | Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 and Akt2 with the IC50 of 3.5 nM and 42 nM respectively. It has potent and balanced activity. It is dependent on the PH-domain for Akt inhibition. It is selective for Akt1/2 over Akt3 and is highly selective over other members of the AGC family of kinases in vitro. It has potent inhibitory activity against Akt1 and Akt 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. It has moderate activity in an hERG binding assay and is a substrate for human P-glycoprotein. It also shows good physical properties with a human plasma protein binding. Uses: Akt1 and akt2-in-1 has potent inhibitory activity against akt1 and akt 2 and efficacy in a tumor xenograft model. Synonyms: Akt Inhibitor 17; Akti_2008; Akti 2008; Akti2008; Akti-2008; Akt Inhibitor 17; Akt-Inhibitor-17; AktInhibitor17; 3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one; Akti_2008; 3-phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one. Grade: >98%. CAS No. 893422-47-4. Molecular formula: C33H29N7O. Mole weight: 539.63. | |
| Akt1 Antibody [C19L11] | Akt1 Antibody [C19L11]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F0217. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| Akt Activator II, SC79 (Ethyl-2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate) | A cell-permeable and blood-brain barrier permeant HA14-1 analog that interacts with Akt PH domain PtdIns(3,4,5)P3- (PIP3) binding pocket, rendering Akt in a conformation susceptible to phosphorylation by upstream kinases. Shown to enhance both basal and receptor-mediated Akt phosphorylation (Thr308 and Ser473; 2 to 4ug/ml) with concomitant inhibition Akt membrane translocation in various cell cultures. Efficiently reduces glutamate-induced neurotoxicity both in primary neuron cultures (EC50 = 4ug/ml) in vitro and in a murine MCAO model (40mg/kg, i.p.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 305834-79-1. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?. US Biological Life Sciences. | Worldwide |
| Akt Control Cell Extracts (Rac PKa, PKBa) | Akt Control Cell Extracts (Rac PKa, PKBa). Group: Biologicals. Grades: Lysate. Pack Sizes: 10Blots. US Biological Life Sciences. | Worldwide |
| Akt, dephosphorylated Positive Control (Ser473) (Rac PKa, PKBa) | Positive control for A1124-02D. Group: Molecular Biology. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| Akt-I-1 | AKT-I-1 is a selective and reversible inhibitor of Akt1. Synonyms: Akt-I-1 compound; AktI 1; N3-(7-Cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N1,N1,2,2-tetramethyl-1,3-propanediamine. CAS No. 473382-39-7. Molecular formula: C22H30N6. Mole weight: 378.51. | |
| Akti-1/2 | Akti-1/2. Group: Biochemicals. Alternative Names: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C34H29N7O. US Biological Life Sciences. | Worldwide |
| Akti-1/2 (1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one) | Allosteric Akt (PKB) inhibitors used in synergistic combination therapy for the treatment of cancer. Group: Biochemicals. Alternative Names: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]guinoxalin-7-yl)phenyl]methyl]4-piperidinyl]-2H-benzimidazol-2-one. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| Akt-I-1,2 HCl | Akt-I-1,2 is a selective, non-ATP-competitive Akt1 and Akt2 inhibitor. Synonyms: Akt I 1,2 HCl; AktI1,2 HCl; Benzenemethanamine, alpha,alpha-dimethyl-4-(3-phenyl-2-quinoxalinyl)-, hydrochloride (1:1). CAS No. 473382-50-2. Molecular formula: C23H22ClN3. Mole weight: 375.90. | |
| AKTide-2T | AKTide-2T, a peptide substrate for Akt/PKB, has been found to act as an inhibitor and mimics the optimal phosphorylation sequence of Akt. Synonyms: AKTide-2T; 324029-01-8; ARKRERTYSFGHHA; AKOS024457090; PD079315. Grade: ≥95% by HPLC. CAS No. 324029-01-8. Molecular formula: C74H114N28O20. Mole weight: 1715.89. | |
| AKTide-2T | AKTide-2T. Group: Biochemicals. Grades: Purified. CAS No. 324029-01-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AKTide-2T TFA | AKTide-2T is a peptide substrate for Akt/PKB. It acts as an inhibitor and mimics the optimal phosphorylation sequence of Akt. Molecular formula: C76H115F3N28O22. Mole weight: 1829.89. | |
| AKT-IN-11 | AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC50 of 1.15 μM. Synonyms: (7R)-5-chloro-3-((1E,3E)-3,5-dimethylhepta-1,3-dien-1-yl)-7-hydroxy-7-methyl-2-(4-(trifluoromethoxy)benzyl)isoquinoline-6,8(2H,7H)-dione. Molecular formula: C27H27ClF3NO4. Mole weight: 521.96. | |
| AKT-IN-2 | AKT-IN-2 is a selective and orally bioavailable AKT inhibitor (IC50 = 5 nM for AKT1). Synonyms: AKT-IN-2; CHEMBL4129379; SCHEMBL1662401; QRULDXBXPXGMQS-QGZVFWFLSA-N; QRULDXBXPXGMQS-QGZVFWFLSA-O; BDBM50271964; AKOS040732404; HY-112148; CS-0043488; (R)-5-methyl-4-(4-(1-(2-(pyrrolidin-1-yl)ethyl)-4-(3,3,3-trifluoropropyl)-1H-imidazol-2-yl)piperidin-1-yl)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one; 1295514-91-8. CAS No. 1295514-91-8. Molecular formula: C25H34F3N7O. Mole weight: 505.58. | |
| AKT-IN-23 | AKT-IN-23 is an AKT inhibitor. AKT-IN-23 can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1226801-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161704. | |
| AKT-IN-3 | AKT-IN-3 is a potent and orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 also shows good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. Synonyms: 2-Piperidineacetamide, 5-[[[5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furanyl]carbonyl]amino]-4-(3,4-difluorophenyl)-N-methyl-, (2S,4S,5S)-. CAS No. 2374740-21-1. Molecular formula: C23H23Cl2F2N5O3. Mole weight: 526.36. | |
| AKT-IN-5 | AKT-IN-5 is an inhibitor of Akt1 and Akt2 with IC50s of 450 nM and 400 nM, respectively. CAS No. 1402608-05-2. Molecular formula: C23H20N4O2. Mole weight: 384.43. | |
| Akt Inhibitor, Isozyme-selective (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one; Akti-1/2) | Cell-permeable. A potent and selective inhibitor of Akt1/Akt2 activity (IC?? = 58nM (Akt1), 210nM (Akt2) and 2.12uM (Akt3) in in vitro kinase assays). The inhibition appears to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations (50uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Akt Inhibitor IV | Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Synonyms: 5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide. Grade: ≥95%. CAS No. 681281-88-9. Molecular formula: C31H27N4S·I. Mole weight: 614.6. | |
| AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity. It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. It also prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice. Synonyms: AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730. 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-. Grade: >98%. CAS No. 612847-09-3. Molecular formula: C34H29N7O. Mole weight: 551.64. | |
| AKT inhibitor VIII | AKT inhibitor VIII (AKTi-1/2) is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity with IC50s of 58 nM, 210 nM, and 2119 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AKTi-1/2. CAS No. 612847-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10355. | |
| Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Akti-1/2) | A cell-permeable, reversible, potent, and selective inhibitor of Akt1/Akt2 activity (IC50=58nM, 210nM, and 2.12uM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50uM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation / activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 612847-09-3. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Akt Inhibitor XIX, 3CAI (2-Chloro-1-(1H-indol-3-yl)-ethanone, 3-Chloroacetyl-indole) | A cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1uM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4uM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50=30mg/kg; 5 times/wk for 3 wks via p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 28755-03-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Akt Inhibitor XVI, AT7867 (p70S6K Inhibitor III, 4-(4-Chlorophenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine, PKA Inhibitor XIV, Chlorophenyl-pyrazolyl-phenyl-piperidine, S6K1 Inhibitor III) | A cell-permeable pyrazolo compound that acts as a potent inhibitor against Akt (IC50 = 32, 17, and 47nM against Akt1, Akt2, and Akt3, respectively), PKA (IC50 = 20nM), and p70S6K (IC50 = 85nM) in an ATP-competitive manner (Ki = 18nM using AKT2), with much reduced potency toward RSK1 (IC50 >100nM) and a panel of 13 other cellular kinases (IC50 >1uM). Shown to reduce cellular phosphorylation of GSK-3beta (IC50 range from 2.08 to 4.45uM), S6R, FKHRL1, and inhibit the proliferation of cancer cells exhibiting constitutive Akt pathway activation both in vitro (IC50 range from 0.94 to 11.86uM) and in mice in vivo (20mg/kg via i.p. or 90mg/kg via p.o.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??ClN?. US Biological Life Sciences. | Worldwide |
| AKT Kinase Inhibitor | AKT Kinase Inhibitor is a Akt Kinase Inhibitor. Synonyms: 2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-. Grade: >98%. CAS No. 842148-40-7. Molecular formula: C16H19N7O3. Mole weight: 357.37. | |
| AKT Kinase Inhibitor | AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 842148-40-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10249A. | |
| AK-toxin I | It is produced by the strain of Alternaria kikuchiana AS-1223. It's a plant toxin (especially for pear trees). Synonyms: CTK3E8898; (2E,4E,6E)-8-(2-acetamido-3-phenyl-butanoyl)oxy-8-(2-methyloxiran-2-yl)octa-2,4,6-trienoic Acid. Grade: 95%. CAS No. 85146-09-4. Molecular formula: C23H27NO6. Mole weight: 413.46. | |
| AK-toxin ll | It is produced by the strain of Alternaria kikuchiana AS-1223. It's a plant toxin (especially for pear trees). Synonyms: L-Phenylalanine, N-acetyl-, 7-carboxy-1-(2-methyloxiranyl)-2,4,6-heptatrienyl ester, (2S-(2R*(1S*,2E,4Z,6E)))-. Grade: 95%. CAS No. 85146-10-7. Molecular formula: C22H25NO6. Mole weight: 399.44. | |
| Akt (pan) Antibody [E16N17] | RAC-beta serine / threonine-protein kinase, Protein kinase Akt-2, PKB beta 1, RAC-PK-beta, RAC-gamma serine / threonine-protein kinase, Akt-3, PKB gamma, RAC-PK-gamma, STK-2, AKT3, PKBG, RAC-alpha serine / threonine-protein kinase, PKB, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1. Group: Antibodies. Alternative Names: AKT1, AKT2, AKT3. Pack Sizes: 20ul. Product ID: F0004. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| Akt/SKG Substrate Peptide | Akt/SKG Substrate Peptide is a synthetic peptide and used as a substrate for Akt/PKB. It could not be phosphorylated by MAP kinase or p70 S6 kinase activated protein kinase-1. Synonyms: N5-(Diaminomethylene)-L-ornithyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-alanyl-L-alanyl-L-threonyl-L-phenylalanine. CAS No. 276680-69-4. Molecular formula: C36H59N13O9. Mole weight: 817.95. | |
| Akt/SKG Substrate Peptide | Akt/SKG Substrate Peptide. Group: Biochemicals. Grades: Purified. CAS No. 276680-69-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| AKU-005 | AKU-005 is a FAAH and MAGL dual inhibitor with IC50 values of 63, 389 nM for rat and human FAAH, respectively. AKU-005 has the potential for the research of trigeminal hyperalgesia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1515855-85-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163733. | |
| Al0.2CoCrFeNi Alloy Powder | Al0.2CoCrFeNi Alloy Powder. |  |
| AL-034 | AL-034 is a Toll-like receptor 7 (TLR7) agonist in a phase I clinical trial for the treatment of HBV infections. Uses: The potential treatment of hbv infections. Synonyms: AL-034; AL 034; AL034. | |
| Al0.5CoCrFeNi Alloy Powder | Al0.5CoCrFeNi Alloy Powder. | |
| AL-072 | AL072 is an antibiotic against Legionella produced by Strepyomyces sp. AL91. It has strong anti-legionella pneumophila activity. CAS No. 168482-44-8. Molecular formula: C41H76O5. Mole weight: 649.04. | |
| AL 082D06 | AL 082D06, also called as D-06, is a selective nonsteroidal antagonist of glucocorticoid receptor (GR) (Ki= 210 nM) without significant activity on AR, PR, MR and ER(Ki > 10 uM). AL 082D06 binds competitively with steroids, likely occupying a similar site. Synonyms: AL082D06; AL-082D06; AL 082D06; D-06. CAS No. 256925-03-8. Molecular formula: C23H24ClN3O2. Mole weight: 409.91. | |
| AL 082D06 | AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D06; D-06. CAS No. 256925-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15709. | |
| Al1.8CrCuFeNi2 Alloy Powder | Al1.8CrCuFeNi2 Alloy Powder. | |
| Al2O3 Alumina Spherical Powder / Aluminum Oxide Spherical Powder | Al2O3 Alumina Spherical Powder / Aluminum Oxide Spherical Powder. CAS No. 1344-28-1. Mole weight: 101.96 g/mol. Purity: 99.9%. | |
| Al2O3 nanopowder | Al2O3 nanopowder. Purity: 99%. | |
| AL-3152 | AL-3152 is a aldehyde reductase inhibitors originated by Alcon. But clinical trials was discontinued for the treatment of Diabetic nephropathies, Diabetic neuropathies and Diabetic retinopathy. Uses: Diabetic nephropathies; diabetic neuropathies; diabetic retinopathy. Synonyms: AL-3152; AL 3152; AL3152; 2,7-difluoro-4-methoxy-Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione. Grade: 98%. CAS No. 126048-33-7. Molecular formula: C16H10F2N2O3. Mole weight: 316.62. | |
| AL-321 | AL-321 is a bio-active chemical, but no detailed information has been published yet. Synonyms: AL-321; AL321; AL 321; 5-((4-(2-methyl-2-phenylpropoxy)phenyl)methyl)- 2,4-Thiazolidinedione. Grade: 98%. CAS No. 74772-68-2. Molecular formula: C20H21NO3S. Mole weight: 355.45. | |
| AL 34662 | AL 34662 is a potent 5-HT2 receptor agonist with ocular hypotensive activity. Uses: Serotonin 5-ht2 receptor agonists. Synonyms: AL 34497; 1-((S)-2-aminopropyl)-1H-indazol-6-ol; 1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-. Grade: ≥98%. CAS No. 210580-75-9. Molecular formula: C10H13N3O. Mole weight: 191.2. | |
| AL-3803 | AL-3803, a spiro derivative, has been found to have some extent of biological activity in drug researches. Synonyms: AL-3803; AL 3803; AL3803; (-)-AL03152; AC1MIXPX; (-)-AL03152; Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2,7-difluoro-4-methoxy-, (S)-; (9S)-2,7-difluoro-4-methoxyspiro[fluorene-9,5'-imidazolidine]-2',4'-dione. Grade: 98%. CAS No. 145555-03-9. Molecular formula: C16H10F2N2O3. Mole weight: 316.26. | |
| AL 6598 | AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 μM and demonstrates an EC50 value of 0.80 μM in an in vitro functional assay. Synonyms: propan-2-yl 2-[(Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(3R)-3-cyclohexyl-3-hydroxypropyl]-3-hydroxycyclopentyl]but-2-enoxy]acetate. Grade: ≥97%. CAS No. 170291-06-2. Molecular formula: C23H39ClO5. Mole weight: 431. | |
| AL 8697 | AL 8697 is an effective and selective p38α inhibitor and has been found to exhibit some antiinflammatory activities. Synonyms: AL 8697; AL8697; AL-8697; N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide. Grade: ≥98% by HPLC. CAS No. 1057394-06-5. Molecular formula: C21H21F3N4O. Mole weight: 402.41. | |
| AL 8697 | AL 8697. Group: Biochemicals. Grades: Purified. CAS No. 1057394-06-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| AL 8810 | AL 8810 is a prostaglandin F2a analog and a selective FP prostanoid receptor antagonist. AL-8810 produced a concentration-dependent shift in the fluprostenol concentration-response curve, without significantly decreasing the maximal response. AL-8810 has weak agonist potency with EC50 of 261 +/- 44 nM (n = 3) and Emax = 19% (relative to the full FP receptor agonist cloprostenol) in A7r5 cells and EC50 of 186 +/- 63 nM (n = 3) and Emax = 23% in 3T3 fibroblasts. Uses: Prostaglandin antagonists. Synonyms: AL-8810; 246246-19-5; AL 8810; AL8810; (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-fluoro-5-hydroxycyclopentyl]hept-5-enoic acid; 12QE8J6004; 5-Heptenoic acid, 7-((1R,2R,3S,5S)-2-((1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl)-3-fluoro-5-hydroxycyclopentyl)-, (5Z)-; 5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-; 5-Heptenoic acid, 7-((1R,2R,3S,5S)-2-((1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propenyl)-3-fluoro-5-hydroxycyclopentyl)-, (5Z)-. Grade: ≥98%. CAS No. 246246-19-5. Molecular formula: C24H31O4F. Mole weight: 402.5. | |
| AL-8810 | AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 246246-19-5. Pack Sizes: 1 mg. Product ID: HY-100449. | |
| AL 8810 isopropyl ester | AL 8810 is a prostaglandin F2a analog and a selective FP prostanoid receptor antagonist. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost and Travoprost. Synonyms: AL 8810 isopropyl ester; Propan-2-yl (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-fluoro-5-hydroxycyclopentyl]hept-5-enoate; 5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, 1-methylethyl ester, (5Z)-; HMS3648C21; AKOS025294879; SR-01000946200; SR-01000946200-1; 9alpha, 15R- dihydroxy- 11beta- fluoro- 15- (2, 3- dihydro- 1H- inden- 2- yl)- 16, 17, 18, 19, 20- pentanor- prosta- 5Z, 13E- dien- 1- oic acid, isopropyl ester. Grade: ≥98%. CAS No. 208114-93-6. Molecular formula: C27H37FO4. Mole weight: 444.6. | |
| AL 8810 methyl ester | AL 8810 is a prostaglandin F2a analog and a selective FP prostanoid receptor antagonist. AL 8810 methyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost and Travoprost. Synonyms: AL 8810 methyl ester; 1176541-11-9; methyl (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-fluoro-5-hydroxycyclopentyl]hept-5-enoate; CHEBI:186084; DTXSID001347566; methyl (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-luoro-5-hydroxycyclopentyl]hept-5-enoate. Grade: ≥98%. CAS No. 1176541-11-9. Molecular formula: C25H33FO4. Mole weight: 416.5. | |
| AL-9 | AL-9 is a inhibitor of PI4KIIIα, with the IC50 of 0.57 μM, that can inhibit HCV replication[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 869218-90-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118525. | |
| Ala (3-CN)5-Oxytocin | Ala (3-CN)5-Oxytocin is an impurity of Oxytocin, which is a mammalian neurohypophysial hormone used as a vasodilator agent. Synonyms: [5-(3-Cyanoalanine)]oxytocin; [Ala(3-CN)5] Oxytocin; L-Cystyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-β-3-cyano-alanyl-L-cystyl-L-leucyl-L-prolyl-L-glycinamide (disulfide bridge between cysteines); Oxytocin, 5-(3-cyano-L-alanine)-; H-Cys-Tyr-Ile-Gln-Ala(3-CN)-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Oxytocin EP Impurity F; 5-(3-Cyano-L-alanine)oxytocin. Grade: ≥95%. CAS No. 87590-89-4. Molecular formula: C43H64N12O11S2. Mole weight: 989.18. | |
| ALA-ALA-ALA | ALA-ALA-ALA is a substrate for dipeptidyl peptidase II (DPP II). Synonyms: Alanyl-alanyl-alanine; L-alanyl-L-alanyl-L-alanine; Tri-L-alanine; L-Ala-L-Ala-L-Ala; (S)-2-((S)-2-((S)-2-Aminopropanamido)propanamido)propanoic acid. CAS No. 5874-90-8. Molecular formula: C9H17N3O4. Mole weight: 231.25. | |
| ALA-ALA-ALA-ALA-ALA | ALA-ALA-ALA-ALA-ALA. Synonyms: alanyl-alanyl-alanyl-alanyl-alanine; (2S,5S,8S,11S,14S)-14-amino-2,5,8,11-tetramethyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid; Pentaalanine. Grade: >98%. CAS No. 10183-34-3. Molecular formula: C15H27N5O6. Mole weight: 373.40. | |
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