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| Product | Description | |
|---|---|---|
| BAY-1895344 | BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients. Uses: A selective atr (ataxia-telangiectasia and rad3 related protein) inhibitor used for the treatment of advanced solid tumors and lymphomas. Synonyms: BAY-1895344; BAY 1895344; BAY1895344; (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine. Grades: ≥98 %. CAS No. 1876467-74-1. Molecular formula: C20H21N7O. Mole weight: 375.181. |  |
| BAY-1895344 hydrochloride | BAY-1895344 is a potent, orally available and highly selective ATR inhibitor (IC50= 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibited hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM). Synonyms: Elimusertib hydrochloride; BAY 1895344 hydrochloride; BAY1895344 hydrochloride; 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine hydrochloride; 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine hydrochloride; Bay 1895344; 1,7-Naphthyridine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-, hydrochloride (1:1). Grades: ≥95%. Molecular formula: C20H22ClN7O. Mole weight: 411.89. | |
| BAY 19-8004 | BAY 19-8004 is a selective inhibitor of phosphodiesterase-4 (PDE4) used for the treatment of COPD. Uses: The treatment of copd. Synonyms: Lirimilast; SMR004703312; [3-(carbamoylamino)-2-(2,4-dichlorobenzoyl)-1-benzofuran-6-yl] methanesulfonate. Grades: 98%. CAS No. 329306-27-6. Molecular formula: C17H12Cl2N2O6S. Mole weight: 443.26. | |
| BAY-218 | BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC 50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 1. CAS No. 2162982-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111449. |  |
| BAY-218 | BAY-218, which is known as BAY-2335218, is a potent and selective small-molecule AhR inhibitor with an IC50 of 39.9 nM in human cell line. It is a new modality to counteract tumor immunosuppression. Synonyms: BAY 218; BAY218; BAY-2335218; BAY 2335218; BAY2335218; (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide; AHR antagonist 1. Grades: ≥98%. CAS No. 2162982-11-6. Molecular formula: C20H17ClFN3O3. Mole weight: 401.82. | |
| BAY-2402234 | BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity. In vitro, it potently inhibits proliferation of AML cell lines in the sub-nanomolar to low-nanomolar range. BAY 2402234 induces differentiation of AML cell lines also in a sub-nanomolar to low-nanomolar range, demonstrating the anticipated mode of action in cellular mechanistic assays. In vivo, BAY 2402234 exhibits strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. Group: Inhibitors. Alternative Names: BAY-2402234; BAY 2402234; BAY2402234; Orludodstat; Orludodstatum. CAS No. 2225819-06-5. Molecular formula: C21H18ClF5N4O4. Mole weight: 520.84. Appearance: Solid powder. Purity: >98%. IUPACName: (S)-N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide. Canonical SMILES: FC1=C (NC (C2=CC (F)=C (N3N=C (CO)N (CC)C3=O)C=C2O[C@@H] (C)C (F) (F)F)=O)C (Cl)=CC=C1. Catalog: ACM2225819065. |  |
| BAY 2416964 | BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC 50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2242464-44-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135829. | |
| BAY 2416964 | BAY 2416964 is a potent, orally active, aromatic hydrocarbon receptor (AHR) antagonist, which has the potential to treat solid tumors. Synonyms: BAY2416964; (S)-6-(4-Chlorophenyl)-N-(1-Hydroxypropan-2-Yl)-2-(1-Methyl-1H-Pyrazol-4-Yl)-3-Oxo-2,3-Dihydropyridazine-4-Carboxamide. Grades: ≥98% by HPLC. CAS No. 2242464-44-2. Molecular formula: C18H18ClN5O3. Mole weight: 387.8. | |
| BAY-27-9955 | BAY-27-9955 is a specific glucagon receptor antagonist. Synonyms: 1-[2-(4-fluorophenyl)-4,6-di(propan-2-yl)-3-propylphenyl]ethanol; BAY-27-9955; BAY-27-9955; BAY-27-9955; BAY-279955; BAY-279955; BAY-279955; (+)-3,5-diisopropyl-2-(1-hydroxyethyl)-6-propyl-4'-fluoro-1,1'-biphenyl. Grades: >98%. CAS No. 202855-56-9. Molecular formula: C23H31FO. Mole weight: 342.49. | |
| BAY-293 | BAY-293 is a potent and cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM. It shows antiproliferative activity against wild-type KRAS cell lines with IC50 of 1 uM and cell lines with KRASG12C mutation with IC50 of 3 uM by preventing formation of the KRAS-SOS1 complex. It is a valuable chemical probe for future investigations. Synonyms: BAY 293; BAY293; (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine. Grades: ≥98%. CAS No. 2244904-70-7. Molecular formula: C25H28N4O2S. Mole weight: 448.58. | |
| BAY 299 | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). Synonyms: BAY-299; BAY 299; BAY299. 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione. Grades: ≥98% by HPLC. CAS No. 2080306-23-4. Molecular formula: C25H23N3O4. Mole weight: 429.47. | |
| Bay 36-7620 | BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Synonyms: (3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one; BAY-36-7620; BAY 36-7620; BAY367620; UNII-0P934RSF8B. Grades: >98 %. CAS No. 232605-26-4. Molecular formula: C19H18O2. Mole weight: 278.349. | |
| BAY-386 | BAY-386 is a novel PAR1 receptor inhibitor that suppresses activation of thrombin and platelet. It is orally active, and has the potential to treat coagulation disorders such as arterial thrombosis. Uses: The potential treatment of coagulation disorders. Synonyms: BAY 386; BAY386. CAS No. 1256941-06-6. Molecular formula: C22H25F3N4O5S. Mole weight: 514.52. | |
| BAY 41-2272 | BAY 41-2272 is an orally active and soluble guanylate cyclases ( sGC ) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 256376-24-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12376. | |
| BAY 41-2272 | BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. Synonyms: BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272. Grades: 98%. CAS No. 256376-24-6. Molecular formula: C20H17FN6. Mole weight: 360.39. | |
| BAY 41-2272 | BAY 41-2272. Group: Biochemicals. Alternative Names: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine. Grades: Highly Purified. CAS No. 256376-24-6. Pack Sizes: 10mg. Molecular Formula: C20H17FN6, Molecular Weight: 360.39. US Biological Life Sciences. |  Worldwide |
| BAY 41-4109 | BAY 41-4109 is a novel drug inhibiting hepatitis B virus capsid formation and replication. Synonyms: BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate. Grades: >98%. CAS No. 298708-81-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.766. | |
| Bay 41-4109 less active enantiomer | Bay 41-4109 less active enantiomer exhibits less activity than Bay 41-4109 that is a novel class of drugs and inhibits hepatitis B virus (HBV) capsid formation and replication. Synonyms: methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY 41-4109; methyl-(R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-pyrimidine-5-carboxylate. Grades: ≥98% (HPLC). CAS No. 476617-51-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY41-4109 racemic | BAY41-4109 racemic, a mixture of R-isomer of BAY41-4109 and S-isomer of BAY41-4109, is an antiviral compound that inhibits HBV replication by destabilizing capsid assembly, with an IC50 of 53 nM. Synonyms: Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. Grades: ≥98.0%. CAS No. 298708-79-9. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY-41-8543 | BAY-41-8543, with antihypertensive, is a heme-dependent stimulator of NO-independent guanylyl cyclase (sGC). In vivo, BAY 41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis. In vitro, BAY 41-8543 induces relaxation of aorta, saphenous arteries, coronary arteries and veins. Synonyms: -[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine; BAY-41-8543; BAY418543; BAY41-8543; UNII-323T2C09SG. Grades: 95%. CAS No. 256498-66-5. Molecular formula: C21H21FN8O. Mole weight: 420.44. | |
| BAY-545 | BAY-545 is a potent and selective A2B adenosine receptor antagonist with IC50 of 59 nM. Synonyms: GTPL11224; EX-A2960; BAY 545; BAY545. Grades: 98%. CAS No. 1699717-32-2. Molecular formula: C18H22F3N3O4S. Mole weight: 433.4. | |
| BAY-549 | BAY-549 (Azaindole 1) is an orally active and ATP-competitive ROCK inhibitor with IC 50 s of 0.6 and 1.1?nM for human ROCK-1 and ROCK-2 , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ROCK-IN-2; Azaindole 1; TC-S 7001. CAS No. 867017-68-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10319. | |
| BAY-5516 | BAY-5516 is a inverse-agonist o PPAR G, with the IC 50 value of 6.1±3.6 nM that has anti-tumor effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2891706-79-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160160. | |
| Bay 55-9837 | Bay 55-9837 is a selective VPAC2 receptor agonist (EC50 = 0.4, 100 and >1000 nM for VPAC2, VPAC1 and PAC1, respectively in a cAMP accumulation assay; IC50=60, 8700 and >10000 nM for VPAC2, VPAC1 and PAC1, respectively in a competition binding assay). It promotes glucose-dependent insulin secretion in isolated human pancreatic islets and inhibits HIV-1 viral replication. CAS No. 463930-25-8. Molecular formula: C167H270N52O46. Mole weight: 3742.29. | |
| Bay 55-9837 | Bay 55-9837. Group: Biochemicals. Grades: Purified. CAS No. 463930-25-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| BAY 56-3722 | BAY 56-3722 is a water-soluble camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic activity. BAY 56-3722 stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. The peptide carbohydrate moiety of this agent stabilizes the lactone form of camptothecin in blood. Synonyms: BAY-563722; BAY56 3722; BAY 38-3441; BAY 38 344; (S)-4-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ((4-(((2R,3S,4R,5R,6S)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)carbamothioyl)-L-histidyl-L-valinate. CAS No. 215604-75-4. Molecular formula: C45H50ClN7O11S. Mole weight: 895.98. | |
| BAY 56-3722 hydrochloride | BAY 56-3722, a water-soluble camptothecin derivative, is a DNA-Intercalating drug that stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Synonyms: BAY 56-3722; BAY56-3722; BAY-56-3722; N-[4- (6-Deoxy-3-O-methyl-beta-L-galactopyranosyloxy) phenylaminothiocarbonyl]-L-histidyl-L-valine 4(S)-ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl ester hydrochloride; N-[4-(3-O-Methyl-beta-L-fucopyranosyloxy)p; Afeletecan hydrochloride; BAY 38-3441; L-Valine, N- ( ( (4- ( (6-deoxy-3-O-methyl-beta-L-galactopyranosyl) oxy) phenyl) amino) thioxomethyl) -L-histidyl-, (4S)-4-ethyl-3,4,12,14-tetrahydro-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-4-yl ester, hydrochloride (1:1); 215604-75-4 (BAY 56-3722 free base); 215604-74-3 (BAY 56-3722 HCl salt; 215604-66-3 (diastereomeric mixture). Grades: >98%. CAS No. 215604-74-3. Molecular formula: C45H49N7O11S.HCl. Mole weight: 932.447. | |
| BAY-57-1293 | BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. Uses: For research used only. Synonyms: Pritelivir; BAY-57-1293; BAY 57-1293; BAY-57 1293; BAY 57 1293; BAY571293; AIC316; AIC 316; AIC-316. Grades: 98%. CAS No. 348086-71-5. Molecular formula: C18H18N4O3S2. Mole weight: 402.49. | |
| BAY 58-2667 hydrochloride | Nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Shows potent cardiovascular effects. Improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Exhibits potent vasodilator and antiplatelet activity. Anti-aggregating agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1240669-95-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| BAY 58-2667 hydrochloride | BAY 58-2667, also known as Cinaciguat, is a potent nitric oxide (NO)-independent soluble guanylyl cyclase (sGC) activator (EC50 = 6.4 nM). It exhibits antihypertensive effects in vivo and is used in the treatment of acute decompensated heart failure (ADHF). Synonyms: 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate Sulfamate; Cinaciguat HCl; BAY 582667 HCl; BAY-582667 HCl; BAY582667 HCl; BAY 58-2667 HCl; BAY-58-2667 HCl; BAY58-2667 HCl; Cinaciguat HCl. Grades: ≥98% by HPLC. CAS No. 646995-35-9. Molecular formula: C36H39NO5.HCl. Mole weight: 602.16. | |
| BAY-588 | BAY-588 is a glucose transporter inhibitor and derivative of BAY-876. BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1. It selectively inhibits glucose transporter 4 (Glut4), Glut1, and Glut3 over Glut2 with IC50 values of 0.5, 1.18, 5.47, and >10 μM, respectively, in CHO cells expressing human recombinant transporters. Synonyms: BAY 588; BAY588; N4-[1-[[4-(1,1-Dimethylethyl)phenyl]methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide. Grades: ≥98%. CAS No. 1799759-24-2. Molecular formula: C27H25F4N5O2. Mole weight: 527.5. | |
| BAY 59-3074 | Bay 59-3074 is a novel, selective CB1/CB2 receptor partial agonist(Ki values are 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively). Uses: Novel cb1/cb2 receptor partial agonist. Synonyms: BAY-59-3074; BAY 59-3074; BAY59-30743-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl 4,4,4-trifluoro-1-butanesulfonic acid ester. Grades: ≥98%. CAS No. 406205-74-1. Molecular formula: C18H13F6NO4S. Mole weight: 453.358. | |
| BAY-598 | BAY-598 is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 values of 27 nM and 58 nM for biochemical and cellular activity, respectively. BAY 598 exhibits 100-fold selectivity for SMYD2 over other histone methyltransferases and non-epigenetic enzymes. Synonyms: (S, E) -N- (1- (N'-cyano-N- (3- (difluoromethoxy) phenyl) carbamimidoyl) -3- (3, 4-dichlorophenyl) -4, 5-dihydro-1H-pyrazol-4-yl) -N-ethyl-2-hydroxyacetamide; BAY-598; BAY 598; BAY598. CAS No. 1906919-67-2. Molecular formula: C22H20Cl2F2N6O3. Mole weight: 525.33. | |
| BAY-598 R-isomer | BAY-598 R-isomer is the R-isomer of BAY589 which is a potent, peptide-competitive chemical probe for SET and MYND domain-containing protein 2 (SMYD2), IC50 values of 27 nM and 58 nM for biochemical and cellular activity, respectively. BAY 598 exhibits 100-fold selectivity for SMYD2 over other histone methyltransferases and non-epigenetic enzymes. Synonyms: (R, E) -N- (1- (N'-cyano-N- (3- (difluoromethoxy) phenyl) carbamimidoyl) -3- (3, 4-dichlorophenyl) -4, 5-dihydro-1H-pyrazol-4-yl) -N-ethyl-2-hydroxyacetamide; BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer. CAS No. 1906920-28-2. Molecular formula: C22H20Cl2F2N6O3. Mole weight: 525.33. | |
| BAY-6035 | BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3) with IC50 of 70 nMm, which exhibits >100-fold selectivity for SMYD3 over other histone methyltransferases. BAY-6035 inhibits methylation of MEKK2 peptide in a cell-free assay and in cell. Synonyms: (2S)-1-(3-azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide. Grades: ≥95%. CAS No. 2247890-13-5. Molecular formula: C22H28N4O3. Mole weight: 396.48. | |
| BAY-6035 | BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC 50 of 88 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247890-13-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112080. | |
| BAY 60-6583 | BAY 60-6583 is a potent and high-affinity agonist of adenosine A 2B receptor ( EC 50 = 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with K i values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model [1] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 910487-58-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103171. | |
| BAY 60-6583 | BAY 60-6583 is a potent and selective adenosine A2B receptor agonist (EC50 = 2.83 nM for murine A2B receptor) displaying selectivity for A2B over A1, A2A and A3 receptors. BAY 60-6583 decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM) and attenuates infarct size in a mouse model of myocardial ischemia, suggesting that it may be beneficial for the treatment of disorders in the coronary arteries, atherosclerosis and ischemia-reperfusion injury. Synonyms: BAY 60-6583; BAY-60-6583; BAY60-6583. 2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; BR 4887. Grades: ≥98% by HPLC. CAS No. 910487-58-0. Molecular formula: C19H17N5O2S. Mole weight: 379.44. | |
| BAY 60-6583 | BAY 60-6583 is a potent and selective adenosine A2B receptor agonist. BAY 60-6583 shows protective effects against ischemia in both the heart and kidney in animal models. BAY 60-6583 is also a useful therapeutic drug in the treatment of acute lung injury. Group: Biochemicals. Alternative Names: 2- [ [6-Amino-3, 5-dicyano-4- [4- (cyclopropylmethoxy) phenyl] -2-pyridinyl] thio] acetamide; BR 4887. Grades: Highly Purified. CAS No. 910487-58-0. Pack Sizes: 10mg, 25mg. Molecular Formula: C19H17N5O2S. US Biological Life Sciences. | Worldwide |
| BAY 60-6583-13C2,15N | BAY 60-6583-13C2,15N. Group: Biochemicals. Alternative Names: 2- [ [6-Amino-3, 5-dicyano-4- [4- (cyclopropylmethoxy) phenyl] -2-pyridinyl] thio] acetamide-13C2, 15N; BR 4887-13C2,15N. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C1713C2H17N415NO2S, Molecular Weight: 382.41. US Biological Life Sciences. | Worldwide |
| Bay 60-7550 | Bay 60-7550 is a potent PDE2 inhibitor. It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A. Synonyms: BAY60-7550; BAY 60-7550; BAY-60-7550; BAY-607550; BAY 607550; BAY607550. Grades: >98%. CAS No. 439083-90-6. Molecular formula: C27H32N4O4. Mole weight: 476.57. | |
| BAY 60-7550 | The compound induced anxiety by inhibition of. Group: Biochemicals. Alternative Names: 2-[ (3, 4-Dimethoxyphenyl) methyl]-7-[ (1R) -1-[ (1R) -1-hydroxyethyl]-4-phenylbutyl]-5-methyl-imidazo[5, 1-f][1, 2, 4]triazin-4 (1H) -one. Grades: Highly Purified. CAS No. 439083-90-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| BAY 61-3606 | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Synonyms: BAY 61-3606; BAY 613606; BAY 61 3606; BAY-61-3606; BAY613606; BAY61 3606. Grades: >98%. CAS No. 732983-37-8. Molecular formula: C20H18N6O3. Mole weight: 390.4. | |
| BAY 61-3606 dihydrochloride | BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. Synonyms: BAY 61-3606 dihydrochloride; BAY-61-3606 dihydrochloride; BAY61-3606 dihydrochloride. Grades: >98%. CAS No. 648903-57-5. Molecular formula: C20H18N6O3.2HCl. Mole weight: 463.32. | |
| BAY 61-3606 hydrochloride | BAY 61-3606 is a cell-permeable, reversible inhibitor of spleen tyrosine kinase (Syk; Ki=7.5 nM; IC50=10 nM). It is 700 to >1,000-fold more selective for Syk over Src, Lyn, Fyn, Itk, and Btk. BAY 61-3606 can inhibit degranulation (IC50 = 5-46 nM) and block cytokine release from mast cells. It shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma. Synonyms: 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide monohydrochloride; BAY 61-3606 HCl. Grades: ≥98%. CAS No. 1615197-10-8. Molecular formula: C20H18N6O3·HCl. Mole weight: 426.9. | |
| Bay 61-3606 Hydrochloride (2-[[7- (3, 4-Dimethoxyphenyl) imidazo[1, 2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl) | Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50 = 10nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7uM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. Group: Biochemicals. Alternative Names: 2-[[7- (3, 4-Dimethoxyphenyl) imidazo[1, 2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl. Grades: Highly Purified. CAS No. 732938-37-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bay 65-1942 free base | Bay 65-1942 is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Synonyms: BAY 65-1942; BAY-65-1942; BAY65-1942; BAY 651942; BAY-651942; BAY651942. BAY65-1942 free base. Grades: >98%. CAS No. 600734-02-9. Molecular formula: C22H25N3O4. Mole weight: 395.45. | |
| Bay 65-1942 hydrochloride | Bay 65-1942 hydrochloride is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Synonyms: KINK-1; KINK 1; KINK1; Bay65-1942 Hydrochloride; Bay651942 Hydrochloride; Bay65-1942 HCl; Bay651942 HCl. Grades: >98%. CAS No. 600734-06-3. Molecular formula: C22H26ClN3O4. Mole weight: 431.91. | |
| Bay 65-1942 R form | Bay 65-1942 R form is an ATP-competitive inhibitor that selectively targets IKKβ kinase. Synonyms: Bay 65-1942. Grades: >98%. CAS No. 758683-21-5. Molecular formula: C22H25N3O4. Mole weight: 395.45. | |
| BAY-671 | BAY-671 is developed from the structure of BRD4 inhibitor used for the treatment of solid tumor. Studies in vtro and in vivo indicated that it has inhibitory effect on multiple cancer types. Uses: The treatment of solid tumor. Synonyms: BAY 671; BAY671. | |
| BAY 677 | BAY 677 is an inactive control for BAY 678 and a human neutrophil elastase (HNE) inhibitor. Synonyms: BAY-677; BAY 677; BAY677; 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 2117404-84-7. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY 678 | BAY 678 is a cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM) that displays around 2000-fold selectivity for NHE over a panel of 21 other serine proteases. Synonyms: BAY 678; BAY678; BAY-678; 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 675103-36-3. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY-707 | BAY-707 is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC 50 of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2109805-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112081. | |
| BAY-721973 | BAY-721973 is a bio-active chemical,but few detailed information has been published yet. Synonyms: BAY-721973; BAY 721973; BAY721973; Sorafenib metabolite M3; UNII-83F1Z938Q0; 4- (4- ( ( ( (4-chloro-3- (trifluoromethyl) phenyl) amino) carbonyl) amino) phenoxy) -N- (hydroxymethyl) -2-Pyridinecarboxamide. Grades: 98%. CAS No. 1380310-94-0. Molecular formula: C21H16ClF3N4O4. Mole weight: 480.83. | |
| BAY 73-4506 | BAY 73-4506 Inhibitor. Uses: Scientific use. Product Category: T1792. CAS No. 755037-03-7. |  |
| BAY 73-6691 | BAY 73-6691 is a phosphodiesterase inhibitor selective for the PDE9A subtype under the development of Bayer. It selectively inhibits human PDE9 with IC50 value of 55 nM in vitro.BAY 73-6691 was developed for the treatment of Alzheimer's disease, but pre-clinical research is at an early stage. Uses: Alzheimer's disease. Synonyms: BAY-73-6691; BAY736691; BAY73-6691; UNII-80ZTV3INTW; (R)-Bay-73-6691; 1-(2-Chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4-one. Grades: 98%. CAS No. 794568-92-6. Molecular formula: C15H12ClF3N4O. Mole weight: 356.73. | |
| BAY-754 | BAY-754 is an ALK-1 inhibitor used as an anti-angiogenesis agent. It inhibited the eye vascular leakage in dose manner in mouse model. Uses: The treatment of eye disorders. Synonyms: BAY-754; BAY 754; BAY-54. | |
| BAY-8002 | BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM), which inhibits cellular lactate uptake in DLD-1 cells with IC50 of 85 nM. BAY-8002 significantly increases intratumor lactate levels and transiently modulated pyruvate levels. Synonyms: BAY 8002BAY-8002; BAY 8002; BAY8002; 2-(2-chloro-5-(phenylsulfonyl)benzamido)benzoic acid. Grades: ≥98%. CAS No. 724440-27-1. Molecular formula: C20H14ClNO5S. Mole weight: 415.85. | |
| BAY8040 | This active molecular is a Selective Human Neutrophil Elastase Inhibitor and combines excellent potency and selectivity with a promising pharmacokinetic profile. In animal models for pulmonary arterial hypertension, BAY8040 shows the efficancy of decreasing cardiac remodeling and amelioration of cardiac function in vivo. Uses: Cardiac remodeling and amelioration of cardiac function. Synonyms: BAY8040; BAY-8040; BAY 8040; (R)-4-(7-methyl-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyridazin-4-yl)benzonitrile. Grades: 98%. CAS No. 1194453-23-0. Molecular formula: C21H16F3N5O2. Mole weight: 427.39. | |
| BAY 826 | BAY-826 is a selective and potent TIE-2 inhibitor with Kd of 1.6 nM and IC50 of 1.3 nM for autophosphorylation. BAY-826 is highly selective against other angiogenic kinases, such as VEGFR, FGFR, or PDGFR, and affects VEGF-stimulated proliferation of HUVEC. It displays in vivo efficacy in some murine glioma models. Synonyms: [3-Cyano-5- [ [ [2, 4-dimethyl-5- [6- (3-pyridinyl) -1H-imidazo [1, 2-b] pyrazol-1-yl] phenyl] amino] carbonyl] phenyl] pentafluorosulfur. Grades: ≥98% by HPLC. CAS No. 1448316-08-2. Molecular formula: C26H19F5N6OS. Mole weight: 558.53. | |
| BAY-850 | BAY-850 is a potent isotype-selective ATPase family AAA domain protein 2 (ATAD2) inhibitor with IC50 of 166 nM and can be used as a probe. Grades: 98%. CAS No. 2099142-76-2. Molecular formula: C38H44ClN5O3. Mole weight: 654.2. | |
| BAY 85-8501 | This active molecular is a highly selective neutrophil elastase inhibitor.IC50 for HNE is 0.065 nM, LipE is 7.2. BAY 85-8501 was being tested in clinical studies for the treatment of pulmonary diseases. In Feb 2013, Phase-II clinical trials in Bronchiectasis in Spain were on going. In Mar 2013, Phase-II clinical trials in Bronchiectasis in France, Germany and Italy were on going. In Jun 2014, Bayer completed a phase IIa trial in Bronchiectasis in United Kingdom, Spain, France, Germany and Italy. Uses: The treatment of pulmonary diseases. Synonyms: BAY 85-8501; BAY85-8501; BAY-85-8501; BAY 858501; BAY858501; BAY-858501. (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1161921-82-9. Molecular formula: C22H17F3N4O3S. Mole weight: 474.46. | |
| BAY 87-2243 | BAY 87-2243 inhibits HIF-1 reporter gene activity and CA9 protein expression with IC50 of 0.7 nM and 2 nM, respectively. Synonyms: BAY 872243; BAY872243; BAY-872243; BAY 87-2243; BAY87-2243; BAY-87-2243. Grades: >98%. CAS No. 1227158-85-1. Molecular formula: C26H26F3N7O2. Mole weight: 525.53. | |
| BAY-876 | BAY-876 is a potent and selective inhibitor of GLUT1, which is overexpressed in multiple cancers. Uses: Anticancer agent. Synonyms: BAY-876; BAY 876; BAY876. 4-N-[1-[(4-cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide. Grades: 95%. CAS No. 1799753-84-6. Molecular formula: C24H16F4N6O2. Mole weight: 496.426. | |
| BAY-876 | BAY-876 Inhibitor. Uses: Scientific use. Product Category: T3713. CAS No. 1799753-84-6. | |
| BAY-876 | BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC 50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1799753-84-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100017. | |
| BAY-985 | BAY-985 is a highly effective, orally active and selective TANK-binding kinase 1 (TBK1) and IκB kinase ε dual inhibitor, with anti-tumor activity. Synonyms: BAY985; GTPL10597; EX-A3294. Grades: ≥98% by HPLC. CAS No. 2409479-29-2. Molecular formula: C27H30F3N9O. Mole weight: 553.6. | |
| Bayberry Bark Extract | Extract obtained from Myrica Cerifera (Bayberry) bark. Contains 20% extract dissolved in water and glycerin. Has tonic, stimulating and cleansing properties. Uses: Creams, lotions, toners, soaps, and bath products. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84929-34-0 / 122-99-6. Appearance: Light to medium amber liquid, herbal odor. Catalog: CI-SC-0872. | |
| Bayberry Extract | Bayberry Extract. Applications: Used for health care products, dietary supplements, herb medecine and cosmetic industry. Group: Others. Synonyms: Bayberry Extract; 529-44-2; Myrica rubra sieb. Et Zucc. CAS No. 529-44-2. Purity: 50%-98% Myricitrin by HPLC, 5-10:1 by TLC. Appearance: Light yellow green fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Bark. Species: Myrica rubra sieb. Et Zucc. Bayberry Extract; 529-44-2; Myrica rubra sieb. Et Zucc; plant extract. Pack: 25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-128. |  |
| Bayberry Myrica Rubra Fruit P.E. 80% Myricetin HPLC | Bayberry Myrica Rubra Fruit P.E. 80% Myricetin HPLC. |  CA, FL & NJ |
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