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| Product | Description | |
|---|---|---|
| BAX Inhibiting Peptide V5 | BAX Inhibiting Peptide V5. Uses: For analytical and research use. CAS No. 579492-81-2. Mole weight: 586.79. Catalog: AP579492812. |  |
| Bax inhibitor peptide, negative control | A negative control peptide for the Bax inhibitor peptide V5, which inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro. Synonyms: L-isoleucyl-L-prolyl-L-methionyl-L-isoleucyl-L-lysine. Grade: >98%. CAS No. 1315378-74-5. Molecular formula: C28H52N6O6S. Mole weight: 600.82. |  |
| Bax inhibitor peptide V5 | Bax inhibitor peptide V5, a peptide inhibitor, as a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. Uses: A pro-apoptotic member of bcl-2 family proteins. Synonyms: L-Valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine. Grade: ≥97% by HPLC. CAS No. 579492-81-2. Molecular formula: C27H50N6O6S. Mole weight: 586.8. | |
| Bax inhibitor peptide V5 | Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIP-V5; BAX Inhibiting Peptide V5. CAS No. 579492-81-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0081. |  |
| Bax inhibitor peptide V5 acetate | Bax inhibitor peptide V5 acetate, a Bax-mediated apoptosis inhibitor, is a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosis. It is used in cancer treatment. Synonyms: BIP-V5 acetate; H-Val-Pro-Met-Leu-Lys-OH.CH3CO2H; VPMLK acetate; L-valyl-L-prolyl-L-methionyl-L-leucyl-L-lysine acetic acid. Grade: ≥95%. CAS No. 2760881-58-9. Molecular formula: C29H54N6O8S. Mole weight: 646.85. | |
| Bay 02752 | Bay 02752 is a bio-active molecular, but no detailed information has been published yet. Synonyms: Bay-02752; Bay 02752; Bay02752; N,N'-(1,11-Undecanediyl) bis (2,3-dihydro-2-methyl-1H-indole-1-carboxamide). Grade: 98%. CAS No. 78991-74-9. Molecular formula: C31H44N4O2. Mole weight: 504.71. | |
| BAY-069 | BAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50 values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2639638-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148242. | |
| BAY-091 | BAY-091, a chemical probe, is a potent and highly selective inhibitor of the kinase PIP4K2A. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922280-34-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139868. | |
| BAY1082439 | BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1375469-38-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100886. | |
| BAY1125976 | BAY1125976 is a selective allosteric AKT1/2 inhibitor, which exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. In in vitro kinase activity assays, BAY 1125976 potently and selectively inhibited the activity of full-length AKT1 and AKT2 by binding into an allosteric binding pocket formed by kinase and PH domain. Synonyms: BAY-1125976; BAY 1125976. CAS No. 1402608-02-9. Molecular formula: C23H21N5O. Mole weight: 383.45. | |
| BAY-1142524 | BAY-1142524 is a chymase inhibitor. Chymase is an enzyme that modulates the production of proteins playing a role in adverse cardiac tissue remodeling and fibrogenesis. Study shows that BAY-1142524 could suppress the abnormal cardiac tissue remodeling after myocardial infarction (MI) and improves cardiac function. Uses: Abnormal cardiac tissue remodeling reduction. Synonyms: BAY-1142524; BAY 1142524; BAY1142524. | |
| BAY-1143572 | BAY 1143572 is a highly selective, potent and orally available inhibitor ofPTEFb/CDK9 and shows convincing anti-tumor activity in multiple xenograft models by the induction of apoptosis. Synonyms: 4-(4-fluoro-2-methoxyphenyl)-N-[3-[(methylsulfonimidoyl)methyl]phenyl]-1,3,5-triazin-2-amine; BAY1143572; BAY 1143572; BAY-1143572. Atuveciclib. CAS No. 1414943-88-6. Molecular formula: C18H18FN5O2S. Mole weight: 387.43. | |
| BAY 11-7082 | IkappaBalpha kinase inhibitor. NF-kappaB inhibitor. Potential anti-inflammatory agent. Apoptosis inducer. Inhibits the release of proinflammatory cytokines. Inflammasome inhibitor Inhibits platelet aggregation. Group: Biochemicals. Alternative Names: (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile. Grades: Highly Purified. CAS No. 19542-67-7. Pack Sizes: 10mg, 50mg. Molecular Formula: C10H9NO2S. US Biological Life Sciences. |  Worldwide |
| BAY 11-7082 | BAY 11-7082 completely and specifically abrogates NF-κB DNA binding, downregulating the NF-κB-inducible cytokine IL-6 and inducing apoptosis. Synonyms: BAY 11-7821; BAY 11-7082; BAY11-7082; BAY-11-7082; BAY 117082; BAY117082; BAY-117082. Grade: >98%. CAS No. 19542-67-7. Molecular formula: C10H9NO2S. Mole weight: 207.25. | |
| BAY 11-7082 | BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 11-7821. CAS No. 19542-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13453. | |
| BAY 11-7082 (BAY 11-7821) | BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells. Group: Inhibitors. Alternative Names: BAY 11-7821. CAS No. 19542-67-7. Pack Sizes: 10mg. Product ID: S2913. Formula: C10H9NO2S. Smiles: CC1=CC=C(C=C1)S(=O)(=O)C=CC#N. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Bay 11-7085 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. Synonyms: Bay 11-7085; Bay-11-7085; Bay11-7085; Bay 117085; Bay-117085; Bay117085. Grade: >98%. CAS No. 196309-76-9. Molecular formula: C13H15NO2S. Mole weight: 249.33. | |
| Bay 11-7085 | Bay 11-7085. Group: Biochemicals. Grades: Purified. CAS No. 196309-76-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BAY 11-7085 | BAY 11-7085 (BAY 11-7083) is an inhibitor of NF-κB activation and phosphorylation of IκBα; it stabilizes IκBα with an IC50 of 10 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 11-7083. CAS No. 196309-76-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10257. | |
| Bay 11-7821 | Bay 11-7821. Group: Biochemicals. Grades: Purified. CAS No. 19542-67-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| BAY1217389 | BAY 1217389 is a potent, and selective inhibitor of the monopolar spindle 1 (MPS1) kinase with an IC50 value less than 10 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1554458-53-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12859. | |
| BAY-1217389 | BAY-1217389, an imidazopyridazin derivative, has been found to be a TTK protein inhibitor that could probably be effective as an antineoplastic agent and also be a potentialcell death stimulant. It is still under Phase I trail for solid tumor. Synonyms: BAY1217389; BAY-1217389; BAY 1217389; N-cyclopropyl-4-(6-(2,3-difluoro-4-methoxyphenoxy)-8-((3,3,3-trifluoropropyl)amino)imidazo[1,2-b]pyridazin-3-yl)-2-methylbenzamide. Grade: 98%. CAS No. 1554458-53-5. Molecular formula: C27H24F5N5O3. Mole weight: 561.51. | |
| BAY1238097 | BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome (IC50 <100 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1564268-08-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112316. | |
| BAY-1251152 | BAY-1251152 is a potent and selective CDK9 inhibitor with anti-tumor activity. Synonyms: BAY 1251152; BAY1251152; (+)-BAY-1251152. Grade: ≥98% by HPLC. CAS No. 1610358-56-9. Molecular formula: C19H18F2N4O2S. Mole weight: 404.4. | |
| BAY 1316957 | BAY 1316957 is a potent and selective human prostaglandin E2 receptor subtype 4 (hEP4-R) antagonist with IC50 of 15.3 nM. Synonyms: BAY-1316957; BAY1316957; 2-(9-Ethyl-6-methyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-4-methyl-1H-benzo[d]imidazole-5-carboxylic acid. Grade: 98%. CAS No. 1613264-40-6. Molecular formula: C27H27N3O3. Mole weight: 441.52. | |
| BAY 1436032 | BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. BAY 1436032 strongly reduces 2-HG (2-hydroxyglutarate) levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations. BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro. Synonyms: 3-(2-[[4-(Trifluoromethoxy)phenyl]amino]-1-[(1R,5R)-3,3,5-trimethylcyclohexyl]-1H-benzimidazol-5-yl)propanoic Acid; BAY-1436032. Grade: ≥98%. CAS No. 1803274-65-8. Molecular formula: C26H30F3N3O3. Mole weight: 489.53. | |
| BAY-1436032 | BAY-1436032 is a novel pan-mutant isocitrate dehydrogenase 1 (IDH1) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1803274-65-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100020. | |
| BAY-179 | BAY-179 is a potent and selective complex I inhibitor with IC50 of 79 nM. Synonyms: BAY 179; BAY179; 2-(1-((1H-Imidazo[4,5-b]pyridin-2-yl)methyl)piperidin-4-yl)-4-(benzofuran-2-yl)thiazole. Grade: 98% by HPLC. CAS No. 2764880-87-5. Molecular formula: C23H21N5OS. Mole weight: 415.5. | |
| BAY-1797 | BAY-1797, a chemical probe, is a potent, orally active, and selective P2X4 antagonist, with an IC50 of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055602-83-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130605. | |
| BAY-1816032 | BAY-1816032, a chemical probe, is a potent and oral available BUB1 (budding uninhibited by benzimidazoles 1) kinase inhibitor with an IC50 of 7 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1891087-61-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103020. | |
| BAY-1816032 | BAY-1816032 is an orally available inhibitor of budding uninhibited by benzimidazoles 1 (BUB1) kinase, which is involved in centromere cohesion and attachment error correction. Synonyms: BAY 1816032; BAY1816032. CAS No. 1891087-61-8. Molecular formula: C27H24F2N6O4. Mole weight: 534.51. | |
| BAY-184 | BAY-184 is a selective and orally active KAT6A and KAT6B inhibitor. BAY-184 inhibits KAT6A/KAT6B activity with an IC50 of 71 nM and 83 nM. respectively BAY-184 inhibits ERα transcriptional activity. BAY-184 inhibits proliferation of diverse breast cancer subtypes, and inhibits tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2520347-03-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159957. | |
| BAY 1892005 | BAY 1892005 is a regulator of p53 protein and acts on p53 condensates without causing mutant p53 reactivation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2036352-13-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-156967. | |
| BAY-1895344 | BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients. Uses: A selective atr (ataxia-telangiectasia and rad3 related protein) inhibitor used for the treatment of advanced solid tumors and lymphomas. Synonyms: BAY-1895344; BAY 1895344; BAY1895344; (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine. Grade: ≥98 %. CAS No. 1876467-74-1. Molecular formula: C20H21N7O. Mole weight: 375.181. | |
| BAY-1895344 hydrochloride | BAY-1895344 is a potent, orally available and highly selective ATR inhibitor (IC50= 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). In cellular mechanistic assays BAY 1895344 potently inhibited hydroxyurea-induced H2AX phosphorylation (IC50 = 36 nM). Synonyms: Elimusertib hydrochloride; BAY 1895344 hydrochloride; BAY1895344 hydrochloride; 2-[(3R)-3-Methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-1,7-naphthyridine hydrochloride; 2-[(3R)-3-methylmorpholin-4-yl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridine hydrochloride; Bay 1895344; 1,7-Naphthyridine, 2-[(3R)-3-methyl-4-morpholinyl]-4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)-, hydrochloride (1:1). Grade: ≥95%. Molecular formula: C20H22ClN7O. Mole weight: 411.89. | |
| BAY 19-8004 | BAY 19-8004 is a selective inhibitor of phosphodiesterase-4 (PDE4) used for the treatment of COPD. Uses: The treatment of copd. Synonyms: Lirimilast; SMR004703312; [3-(carbamoylamino)-2-(2,4-dichlorobenzoyl)-1-benzofuran-6-yl] methanesulfonate. Grade: 98%. CAS No. 329306-27-6. Molecular formula: C17H12Cl2N2O6S. Mole weight: 443.26. | |
| BAY-204 | BAY-204 (BRD3727) is a potent, ATP-competitive, and selective CSNK1α inhibitor (IC50 = 2 nM at 10 μM ATP; 12 nM at 1 mM ATP). BAY-204 can be used for the study of acute myeloid leukemia (AML)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRD3727. CAS No. 2468784-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145940. | |
| BAY-218 | BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AHR antagonist 1. CAS No. 2162982-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111449. | |
| BAY-218 | BAY-218, which is known as BAY-2335218, is a potent and selective small-molecule AhR inhibitor with an IC50 of 39.9 nM in human cell line. It is a new modality to counteract tumor immunosuppression. Synonyms: BAY 218; BAY218; BAY-2335218; BAY 2335218; BAY2335218; (S)-6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide; AHR antagonist 1. Grade: 98%. CAS No. 2162982-11-6. Molecular formula: C20H17ClFN3O3. Mole weight: 401.82. | |
| BAY-2402234 | BAY-2402234 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. Uses: Scientific research. Category: Signaling pathways. CAS No. 2225819-06-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112645. | |
| BAY 2416964 | BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2242464-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135829. | |
| BAY 2416964 | BAY 2416964 is a potent, orally active, aromatic hydrocarbon receptor (AHR) antagonist, which has the potential to treat solid tumors. Synonyms: BAY2416964; (S)-6-(4-Chlorophenyl)-N-(1-Hydroxypropan-2-Yl)-2-(1-Methyl-1H-Pyrazol-4-Yl)-3-Oxo-2,3-Dihydropyridazine-4-Carboxamide. Grade: ≥98% by HPLC. CAS No. 2242464-44-2. Molecular formula: C18H18ClN5O3. Mole weight: 387.82. | |
| BAY 2476568 | BAY 2476568 is a potent and mutant-selective inhibitor targeting EGFR exon20 insertion variants. BAY 2476568 potently inhibits the kinase activity of EGFR exon20 insertion mutants (insASV, insSVD, insNPG) with IC50 values of 0.09 nM, 0.21 nM, and 0.11 nM, respectively. BAY 2476568 inhibits EGFR (Y1068) phosphorylation and reduces the phosphorylation of ERK1/2 and Akt (S473) in Ba/F3 cells expressing EGFR exon20 insertion mutants (insASV, insSVD). BAY 2476568 can be used for the study of non-small cell lung cancer (NSCLC) driven by EGFR exon20 insertion mutations[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2311901-93-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134877. | |
| BAY 2476568 | BAY 2476568 is a potent and selective inhibitor of EGFR, with IC50s of < 0.2 nM for wild-type EGFR and several mutations (EGFRR ex20insSVD, EGFRR ex20insASV and EGFRR ex20insNPG). Synonyms: 4H-Pyrrolo[3,2-c]pyridin-4-one, 3-[(3-fluoro-2-methoxyphenyl)amino]-1,5,6,7-tetrahydro-2-[3-(2-methoxy-2-methylpropoxy)-4-pyridinyl]-. CAS No. 2311901-93-4. Molecular formula: C24H27FN4O4. Mole weight: 454.49. | |
| BAY 249716 | BAY 249716 stabilizes all three p53 protein variants. BAY 249716 also has antitubercular activity (IC90: <0.10 μg/mL for Tuberculosis)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 696628-24-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160922. | |
| BAY-252 | BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50s of 2 μM and 2 μM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2639638-67-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-148242A. | |
| BAY2666605 | BAY2666605 induces the formation of the SLFN12-PDE3A complex, leading to stabilization of SLFN12 and alteration of gene expression patterns, potentially resulting in suppression of cell cycle progression and induction of apoptosis in tumor cells. Molecular formula: C17H12F4N2O2. Mole weight: 352.28. | |
| BAY 2666605 | BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer (WO2019025562A1; example 135)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2275774-60-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145924. | |
| BAY-27-9955 | BAY-27-9955 is a specific glucagon receptor antagonist. Synonyms: 1-[2-(4-fluorophenyl)-4,6-di(propan-2-yl)-3-propylphenyl]ethanol; BAY-27-9955; BAY-27-9955; BAY-27-9955; BAY-279955; BAY-279955; BAY-279955; (+)-3,5-diisopropyl-2-(1-hydroxyethyl)-6-propyl-4'-fluoro-1,1'-biphenyl. Grade: >98%. CAS No. 202855-56-9. Molecular formula: C23H31FO. Mole weight: 342.49. | |
| BAY-2925976 | BAY-2925976 is an α2C adrenergic receptor (ARα2C) antagonist that can be used for the study of obstructive sleep apnea (OSA)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2642235-06-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159639. | |
| BAY-293 | BAY-293 is a potent and cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM. It shows antiproliferative activity against wild-type KRAS cell lines with IC50 of 1 uM and cell lines with KRASG12C mutation with IC50 of 3 uM by preventing formation of the KRAS-SOS1 complex. It is a valuable chemical probe for future investigations. Synonyms: BAY 293; BAY293; (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine. Grade: ≥98%. CAS No. 2244904-70-7. Molecular formula: C25H28N4O2S. Mole weight: 448.58. | |
| BAY-293 | BAY-293, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2244904-70-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114398. | |
| BAY-298 | BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC50s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 can reduce sex hormone levels[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2471978-97-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130249. | |
| BAY 299 | BAY 299 is a potent and selective inhibitor of BRD1 and TAF1 (IC50 = 6-67 and 8-13 nM, respectively) with selectivity over other bromodomains (>30-fold over other members of the BRPF family; BRD9 and ATAD2; >300-fold over BRD4). BAY 299 suppresses binding of BRD1 and TAF1 to histone H4 (IC50 = 575 nM and 0.9 μM, respectively) and histone H3.3 (IC50 = 825 nM and 1.4 μM, respectively). Synonyms: BAY-299; BAY 299; BAY299. 6-(3-Hydroxypropyl)-2-(1,3,6-trimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione. Grade: ≥98% by HPLC. CAS No. 2080306-23-4. Molecular formula: C25H23N3O4. Mole weight: 429.47. | |
| BAY-299 | BAY-299, a chemical probe, is a very potent, dual inhibitor with IC50s of 67 nM for BRPF2 bromodomains (BD), 8 nM for TAF1 BD2, and 106 nM for TAF1L BD2. Uses: Scientific research. Category: Signaling pathways. CAS No. 2080306-23-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107424. | |
| BAY-320 | BAY-320 is a selective and ATP-competitive Bub1 inhibitor that inhibits the kinase activity of Bub1 with an IC50 of 680 nM. BAY-320 inhibits endogenous Bub1-mediated Sgo1 localization. BAY-320 affects cellular mitotic chromosome arrangement and spindle assembly. BAY-320 inhibits cell proliferation. BAY-320 can be used in the study of cancer such as ovarian cancer and cervical cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1445830-50-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104000. | |
| Bay 36-7620 | BAY 36-7620 elective mGlu1 receptor non-competitive antagonist (IC50 = 0.16 μM) with inverse agonist activity. Synonyms: (3aS,6aS)-5-methylidene-3a-(naphthalen-2-ylmethyl)-1,4,6,6a-tetrahydrocyclopenta[c]furan-3-one; BAY-36-7620; BAY 36-7620; BAY367620; UNII-0P934RSF8B. Grade: >98 %. CAS No. 232605-26-4. Molecular formula: C19H18O2. Mole weight: 278.349. | |
| BAY-3827 | BAY-3827, a chemical probe, is a potent and selective AMPK inhibitor with IC50 values of 1.4 nM at low (10 μM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 shows over 500-fold selectivity for most of the 331 kinases. BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 and shows strongest anti-proliferative activity in androgen-dependent prostate cancer cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2377576-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112083. | |
| BAY-3827 | BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at a low, 10 μM ATP concentration and 15 nM at a high, 2 mM ATP concentration. Group: Inhibitors. CAS No. 2377576-35-5. Pack Sizes: 5mg. Product ID: S9833. Formula: C27H25FN6O. Smiles: CCC1=CC=CC=C1C(=O)NC2=N[NH]C3=C2C=C(C4C(=C(C)N(C)C(=C4C#N)C)C#N)C(=C3C)F. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| BAY-386 | BAY-386 is a novel PAR1 receptor inhibitor that suppresses activation of thrombin and platelet. It is orally active, and has the potential to treat coagulation disorders such as arterial thrombosis. Uses: The potential treatment of coagulation disorders. Synonyms: BAY 386; BAY386. CAS No. 1256941-06-6. Molecular formula: C22H25F3N4O5S. Mole weight: 514.52. | |
| BAY-390 | BAY-390, a chemical probe, is a selective, across species active and brain penetrating TRPA1 inhibitor. BAY-390 inhibits hTRPA1 FLIPR, hTRPA1 Ephys, rTRPA1 FLIPR and rDRG Ephys with IC50s of 16, 82, 63 and 35 nM, respectively. BAY-390 can be used for the research of inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2741956-55-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148236. | |
| BAY 41-2272 | BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 256376-24-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12376. | |
| BAY 41-2272 | BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. Synonyms: BAY 41-2272; BAY-41-2272; BAY41-2272; BAY412272; BAY-412272; BAY 412272. Grade: 98%. CAS No. 256376-24-6. Molecular formula: C20H17FN6. Mole weight: 360.39. | |
| BAY 41-2272 | BAY 41-2272. Group: Biochemicals. Alternative Names: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine. Grades: Highly Purified. CAS No. 256376-24-6. Pack Sizes: 10mg. Molecular Formula: C20H17FN6, Molecular Weight: 360.39. US Biological Life Sciences. | Worldwide |
| Bay 41-4109 | BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 298708-81-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100029. | |
| BAY 41-4109 | BAY 41-4109 is a novel drug inhibiting hepatitis B virus capsid formation and replication. Synonyms: BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate. Grade: >98%. CAS No. 298708-81-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.766. | |
| Bay 41-4109 less active enantiomer | Bay 41-4109 less active enantiomer exhibits less activity than Bay 41-4109 that is a novel class of drugs and inhibits hepatitis B virus (HBV) capsid formation and replication. Synonyms: methyl (4R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY 41-4109; methyl-(R)-4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-6-methyl-1,4-dihydro-pyrimidine-5-carboxylate. Grade: ≥98% (HPLC). CAS No. 476617-51-3. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY41-4109 racemic | BAY41-4109 racemic, a mixture of R-isomer of BAY41-4109 and S-isomer of BAY41-4109, is an antiviral compound that inhibits HBV replication by destabilizing capsid assembly, with an IC50 of 53 nM. Synonyms: Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate; BAY-41-4109; BAY41-4109; BAY 41-4109; BAY-414109; BAY414109; BAY 414109. Grade: ≥98.0%. CAS No. 298708-79-9. Molecular formula: C18H13ClF3N3O2. Mole weight: 395.76. | |
| BAY-41-8543 | BAY-41-8543, with antihypertensive, is a heme-dependent stimulator of NO-independent guanylyl cyclase (sGC). In vivo, BAY 41-8543 decreases blood pressure dose-dependently, prolongs bleeding time, and reduces thrombosis. In vitro, BAY 41-8543 induces relaxation of aorta, saphenous arteries, coronary arteries and veins. Synonyms: -[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine; BAY-41-8543; BAY418543; BAY41-8543; UNII-323T2C09SG. Grade: 95%. CAS No. 256498-66-5. Molecular formula: C21H21FN8O. Mole weight: 420.44. | |
| BAY-474 | BAY-474 is a tyrosine-protein kinase c-Met inhibitor. Synonyms: 1,4-dihydro-2,6-dimethyl-4-(3-methyl-1H-indazol-5-yl)-3,5-pyridinedicarbonitrile. CAS No. 1033767-86-0. Molecular formula: C17H15N5. Mole weight: 289.33. | |
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