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| Product | Description | |
|---|---|---|
| CCMQ | CCMQ. Group: Biochemicals. Grades: Purified. CAS No. 132623-44-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| CCMV Gag-(7-25) | It is a cell penetrating peptide. Synonyms: H-Lys-Leu-Thr-Arg-Ala-Gln-Arg-Arg-Ala-Ala-Ala-Arg-Lys-Asn-Lys-Arg-Asn-Thr-Arg-OH; L-lysyl-L-leucyl-L-threonyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-asparagyl-L-lysyl-L-arginyl-L-asparagyl-L-threonyl-L-arginine. Grade: ≥95%. Molecular formula: C93H175N43O25. Mole weight: 2295.70. |  |
| CCP | CCP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-Phenyl-3,9'-bi-9H-carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 1026033-51-1. Molecular formula: C30H20N2. Mole weight: 408.49 g/mol. Product ID: ACM1026033511-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CCPA | CCPA (2-Chloro-N6-cyclopentyladenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis , etc [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Chloro-N6-cyclopentyladenosine. CAS No. 37739-05-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103185. |  |
| CCP peptide TFA | CCP peptide TFA is a synthetic cyclic citrullinated peptide that can be used as the substrate for detecting anti-CCP antibodies serologically. Synonyms: His-Gln-Cys-His-Gln-Glu-Ser-Thr-{Cit}-Gly-Arg-Ser-Arg-Gly-Arg-Cys-Gly-Arg-Ser-Gly-Ser (Disulfide bridge: Cys3-Cys16). Grade: 95%. Molecular formula: C89H146N41F3O34S2. Mole weight: 2455.49. | |
| CC-preferring endodeoxyribonuclease | Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5'- and/or 3'-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4 may be the same enzyme. Group: Enzymes. Synonyms: Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease. Enzyme Commission Number: EC 3.1.21.6. CAS No. 37211-67-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3576; CC-preferring endodeoxyribonuclease; EC 3.1.21.6; 37211-67-9; Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease. Cat No: EXWM-3576. |  |
| CCR-11 | CCR-11. Group: Biochemicals. Alternative Names: 2-Thioxo-5-[[5-[3- (trifluoromethyl) phenyl]-2-furanyl]methylene]-4-thiazolidinone. Grades: Highly Purified. CAS No. 301687-87-6. Pack Sizes: 10mg. Molecular Formula: C15H8F3NO2S2, Molecular Weight: 355.35. US Biological Life Sciences. | Worldwide |
| CCR1 antagonist | CCR1 antagonist is a chemokine CCR1 antagonist. It is used for the treatment of chronic obstructive pulmonary disease. Uses: Ccr1 antagonist is used for the treatment of chronic obstructive pulmonary disease. Synonyms: AZD-4818; AZD 4818; AZD4818. (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-; 2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid. Grade: >98 %. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. | |
| CCR1 antagonist 6 | CCR1 antagonist 6 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 3 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[5-(methylsulfonyl)-3-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[5-(methylsulfonyl)-3-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. CAS No. 2436773-01-0. Molecular formula: C21H23ClN4O3S. Mole weight: 446.95. | |
| CCR1 antagonist 7 | CCR1 antagonist 7 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 4 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[2-[(methylamino)sulfonyl]-4-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[2-(methylsulfamoyl)-4-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. Grade: 98%. CAS No. 2446154-74-9. Molecular formula: C21H24ClN5O3S. Mole weight: 461.96. | |
| CCR1 antagonist 9 | CCR1 antagonist 9 is a potent and selective antagonist of CCR1 with an IC50? of? 6.8 nM in calcium flux assay. Synonyms: 1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide; CCR1 inhibitor 19e; 1H-Pyrazolo[3,4-c]pyridine-4-carboxamide, 1-(4-fluorophenyl)-N-[[2-(methylsulfonyl)-4-pyridinyl]methyl]-; 1-(4-Fluorophenyl)-N-{[2-(methylsulfonyl)-4-pyridinyl]methyl}-1H-pyrazolo[3,4-c]pyridine-4-carboxamide. Grade: ≥95%. CAS No. 1220026-26-5. Molecular formula: C20H16FN5O3S. Mole weight: 425.44. | |
| CCR2 antagonist 1 | CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM. Synonyms: [(1S,3R)-3-{[(1R)-5-Bromo-2,3-dihydro-1H-inden-1-yl]amino}-1-isopropylcyclopentyl][7-(trifluoromethyl)-3,4-dihydro-2(1H)-isoquinolinyl]methanone; Methanone, [(1S,3R)-3-[[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]amino]-1-(1-methylethyl)cyclopentyl][3,4-dihydro-7-(trifluoromethyl)-2(1H)-isoquinolinyl]-; (1R)-5-bromo-N-[(1R,3S)-3-(propan-2-yl)-3-[7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]cyclopentyl]-2,3-dihydro-1H-inden-1-amine. Grade: ≥98%. CAS No. 1683534-96-4. Molecular formula: C28H32BrF3N2O. Mole weight: 549.47. | |
| CCR2 antagonist 3 | CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist. Synonyms: AZD2927; AZD-2927; (S)-4-Fluoro-N-(1-(3-hydroxyazetidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide; 4-Fluoro-N-[(2S)-1-(3-hydroxy-1-azetidinyl)-3-methyl-2-butanyl]-N,3-dimethylbenzamide. Grade: ≥98%. CAS No. 1380100-86-6. Molecular formula: C17H25FN2O2. Mole weight: 308.39. | |
| CCR2-RA | CCR2-RA is a novel C-C chemokine receptor type 2 (CCR2) antagonist. Synonyms: 2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-. Grade: 95%. CAS No. 512177-31-0. Molecular formula: C18H19ClFNO3. Mole weight: 351.8. | |
| CCR3 antagonist 1 | A potent antagonist of CCR3 (IC50= 1.8 nM). Synonyms: CCR3 antagonist 1; CCR 3 antagonist 1; CCR-3 antagonist 1; 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]-2-oxoethyl]thio]-. CAS No. 879399-82-3. Molecular formula: C19H21Cl2N3O4S2. Mole weight: 490.42. | |
| CCR4 Antagonist | A potent CCR4 antagonist. Synonyms: C 021 dihydrochloride; C021 dihydrochloride; C-021 dihydrochloride; 2-(1,4'-Bipiperidine-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine; C-021; CCR4 Antagonist; CHEMBL508207; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolina. CAS No. 864289-85-0. Molecular formula: C27H41N5O2. Mole weight: 467.6. | |
| CCR4 antagonist 2 | CCR4 antagonist 2 is a potent and orally bioavailable small molecule CCR4 antagonist, with IC50s of 40 and 70 nM for Ca2+ flux and (chemotaxis) CTX, respectively. It inhibits Treg trafficking into the tumor microenvironment without suppressing the number of Treg in healthy tissue. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl]-; 1-[(1R)-1-(2,4-Dichlorophenyl)ethyl]-6-{(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl}-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile. Grade: ≥97%. CAS No. 2206788-99-8. Molecular formula: C26H28Cl2N6O. Mole weight: 511.45. | |
| CCR4 antagonist 3 | CCR4 antagonist 3, a potent, selective and orally active CCR4 antagonist, has a novel piperidinyl-azetidine motif with IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. It has antitumor activity. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)-3-piperidinyl]-1-azetidinyl]-. CAS No. 2174938-70-4. Molecular formula: C24H27Cl2N7O. Mole weight: 500.42. | |
| CCR4 antagonist 3 hydrochloride | CCR4 antagonist 3 hydrochloride, a potent, selective and orally active CCR4 antagonist, has a novel piperidinyl-azetidine motif with IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. It has antitumor activity. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)-3-piperidinyl]-1-azetidinyl]-, hydrochloride (1:x). Grade: ≥98%. CAS No. 2174938-71-5. Molecular formula: C24H27Cl2N7O.xHCl. Mole weight: 500.42 (free base). | |
| CCR5 antagonist 1 | CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2 that can inhibit HIV replication. Synonyms: AC-31371; HY-100261. Grade: >98%. CAS No. 716354-86-8. Molecular formula: C39H46ClF2N5O3S. Mole weight: 738.3. | |
| CCR6 antagonist 1 | CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 588674-64-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151435. | |
| CCR6 inhibitor 1 | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2437547-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112701. | |
| CCR6 inhibitor 1 | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50 >30000 nM), and CCR7 (IC50 = 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation and is used in the study of autoimmune diseases and cancer. Synonyms: 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-; 4-{4-[(trans-4-{[5-(Trifluoromethyl)-2-pyridinyl]amino}cyclohexyl)sulfonyl]phenyl}-2-pyridinecarboxamide. Grade: ≥98%. CAS No. 2437547-04-9. Molecular formula: C24H23F3N4O3S. Mole weight: 504.52. | |
| CCR7 Ligand 1 | CCR7 Ligand 1 is an allosteric Ligand and human CC chemokine receptor 7 (CCR7) antagonist with a Kd of 3 nM. It is a thiadiazole-dioxide ligand that suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM. Synonyms: CCR7-Cmp2105; Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N,6-trimethyl-; 3-[(4-{[(1R)-2,2-Dimethyl-1-(5-methyl-2-furyl)propyl]amino}-1,1-dioxido-1,2,5-thiadiazol-3-yl)amino]-2-hydroxy-N,N,6-trimethylbenzamide. Grade: ≥98%. CAS No. 681514-83-0. Molecular formula: C22H29N5O5S. Mole weight: 475.56. | |
| CCT007093 | CCT007093 is a potent PPM1D inhibitor or WIP1 inhibitor that selectively reduces viability of human tumour cell lines. Synonyms: CCT007093; CCT-007093; CCT 007093. Grade: 0.98. CAS No. 176957-55-4. Molecular formula: C15H12OS2. Mole weight: 272.38. | |
| CCT007093 | ?98% (HPLC), powder, yellow. Group: Fluorescence/luminescence spectroscopy. |  |
| CCT018159 | CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 μM for human Hsp90? and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 171009-07-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-110042. | |
| CCT018159 | CCT018159 is a novel inhibitor of heat shock protein (Hsp) 90 with potential anticancer activity. CCT018159 inhibited human Hsp90beta with comparable potency to 17-AAG and with similar ATP-competitive kinetics. The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. CCT018159 caused cell cytostasis associated with a G(1) arrest and induced apoptosis. CCT018159 also inhibited key endothelial and tumor cell functions implicated in invasion and angiogenesis. Synonyms: CCT-018159; CCT 018159. Grade: >98%. CAS No. 171009-07-7. Molecular formula: C20H20N2O4. Mole weight: 352.39. | |
| CCT 018159 | CCT 018159. Group: Biochemicals. Grades: Purified. CAS No. 171009-07-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CCT020312 | CCT020312 is a potent and selective EIF2AK3 activator. Synonyms: HY-119240. CAS No. 324759-76-4. Molecular formula: C31H30Br2N4O2. Mole weight: 650.40. | |
| CCT020312 | CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 324759-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119240. | |
| CCT 031374 hydrobromide | CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. It was shown to block BIO-induced β-catenin stabilization, and reduce nuclear and cytosolic β-catenin levels in mouse L-cells. Synonyms: SR 01000418274; CCT 031374 hydrobromide; SR01000418274; CCT031374 hydrobromide; SR-01000418274; CCT-031374 hydrobromide; 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide. Grade: ≥98% by HPLC. CAS No. 1219184-91-4. Molecular formula: C23H19N3O.HBr. Mole weight: 434.33. | |
| CCT 031374 hydrobromide | CCT 031374 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 1219184-91-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CCT031374 hydrobromide | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CCT 031374 hydrobromide (1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide) | Inhibitor of TCF-dependent transcription. Blocks BIO-induced beta-catenin stabilization; reduces nuclear and cytosolic beta-catenin levels in mouse L-cells. Inhibits growth and reduces TCF-dependent transcription in SW480 colon carcinoma cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 1219184-91-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CCT036477 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CCT036477 | CCT036477 is an inhibitor of Wnt signaling. Studies show that CCT036477 does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes. Group: Biochemicals. Alternative Names: α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine. Grades: Highly Purified. CAS No. 305372-78-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| CCT128930 | CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 885499-61-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13260. | |
| CCT128930 | CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. Synonyms: CCT128930; CCT-128930; CCT 128930. CAS No. 885499-61-6. Molecular formula: C18H20ClN5. Mole weight: 341.8379. | |
| CCT128930 hydrochloride | CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50 = 6 nM). CCT128930 hydrochloride also induces cell cycle arrest, DNA damage, and autophagy. Synonyms: 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine hydrochloride. Grade: 98%. CAS No. 2453324-32-6. Molecular formula: C18H21Cl2N5. Mole weight: 378.30. | |
| CCT129202 | CCT129202 is an inhibitor of Aurora kinase activity and displays a favorable antineoplastic effect in preclinical studies. CCT129202 significantly reversed ABCB1- and ABCG2-mediated MDR in vitro, in vivo and ex vivo by inhibiting the function of their transporters and enhanced the eradication of cancer stem-like cells by chemotherapeutic agents. CCT129202 may be a candidate as MDR reversal agent for antineoplastic combination therapy and merits further clinical investigation. Synonyms: CCT129202; CCT-129202; CCT 129202. CAS No. 942947-93-5. Molecular formula: C23H25ClN8OS. Mole weight: 497.02. | |
| CCT129957 | CCT129957 is an indole derivative and a potent phospholipase C-? (PLC-?) inhibitor with an IC50 of ~3 ?M and a GC50 of 15 ?M. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 ?M[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 883098-58-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111208. | |
| CCT137690 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| CCT 137690 | CCT 137690. Group: Biochemicals. Alternative Names: 3-[[4-[6-Bromo-2-[4-(4-methylpiperazin-1-yl)phenyl]-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]methyl]-5-methylisoxazole. Grades: Highly Purified. CAS No. 1095382-05-0. Pack Sizes: 10mg. Molecular Formula: C26H31BrN8O, Molecular Weight: 551.48. US Biological Life Sciences. | Worldwide |
| CCT-137690 | CCT137690, an aurora kinase inhibitor CCT137690, is a highly selective, orally bioavailable imidazo[4,5-b]pyridine derivative that inhibits Aurora A and B kinases with low nanomolar IC50 values in both biochemical and cellular assays and exhibits anti-proliferative activity against a wide range of human solid tumour cell lines. CCT137690 efficiently inhibits histone H3 and TACC3 phosphorylation (Aurora B and Aurora A substrates, respectively) in HCT116 and HeLa cells. Continuous exposure of tumour cells to the inhibitor causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis. This is accompanied by p53/p21/BAX induction, thymidine kinase 1 (TK1) downregulation and PARP cleavage. Furthermore, CCT137690 treatment of MYCN-amplified neuroblastoma cell lines inhibits cell proliferation and decreases MYCN protein expression. Importantly, in a transgenic mouse model of neuroblastoma (TH-MYCN) that overexpresses MYCN protein and is predisposed to spontaneous neuroblastoma formation, this compound significantly inhibits tumour growth. The potent preclinical activity of CCT137690 suggests that this inhibitor may benefit patients with MYCN amplified neuroblastoma. Synonyms: CCT-137690. CCT 137690. CCT137690. CAS No. 1095382-05-0. Molecular formula: C26H31BrN8O. Mole weight: 551.48. | |
| CCT196969 | This active molecular is a novel , paradox-breaking pan-RAF inhibitor with anti-SRC activity and it blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK -ERK. CCT196969 also prevented growth of xenografts derived from patient tumours with resistance to BRAF and MEK inhibitors. Uses: Effective in drug-resistant braf mutant melanoma. Synonyms: CCT196969; CCT-196969; CCT 196969. N-[4-[(3,4-Dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]urea. Grade: 98%. CAS No. 1163719-56-9. Molecular formula: C27H24FN7O3. Mole weight: 513.52. | |
| CCT239065 | CCT239065 is a mutant protein kinase inhibitor that inhibits signaling downstream of V600EBRAF in cancer cells, blocking DNA synthesis, and inhibiting proliferation. Group: Biochemicals. Alternative Names: N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-(methylthio)phenyl]-N'-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-urea. Grades: Highly Purified. CAS No. 1163719-51-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| CCT241161 | This active molecular is a novel , paradox-breaking pan-RAF inhibitor with anti-SRC activity and it blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK -ERK. CCT 241161 also prevented growth of xenografts derived from patient tumours with resistance to BRAF and MEK inhibitors. Uses: Effective in drug-resistant braf mutant melanoma. Synonyms: CCT241161; CCT-241161; CCT 241161. 1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea. Grade: 98%. CAS No. 1163719-91-2. Molecular formula: C28H27N7O3S. Mole weight: 541.62. | |
| CCT 241533 dihydrochloride | CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM) displaying >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells, and blocks ionizing radiation-induced apoptosis of mouse thymocytes. Synonyms: CCT 241533 dihydrochloride; CCT241533 dihydrochloride; CCT-241533 dihydrochloride; (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1962925-28-5. Molecular formula: C23H27FN4O4.2HCl. Mole weight: 515.41. | |
| CCT241533 hydrochloride | CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC 50 of 3 nM and a K i of 1.16 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431697-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14715B. | |
| CCT241736 | CCT241736 is a potent and orally active and dual FLT3-Aurora inhibitor, which has IC50 values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively. It also inhibits viability of the human FLT3-ITD positive AML cell lines MOLM-13 with 0.1 μM in cellular assay. Synonyms: CCT-241736; CCT 241736. Grade: ≥98%. CAS No. 1402709-93-6. Molecular formula: C22H23Cl2N7. Mole weight: 456.37. | |
| CCT244747 | CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. Synonyms: CCT-244747; CCT 244747; 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile; 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile; (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile. Grade: ≥98%. CAS No. 1404095-34-6. Molecular formula: C20H24N8O2. Mole weight: 408.46. | |
| CCT245232 | CCT245232 is a potent inhibitor of heat shock factor 1 ( HSF1 ). HSF1 is the master regulator of the heat shock response, in which multiple genes are induced in response to temperature increase and other stresses. CCT245232 has the potential for the research of proliferative diseases, such as cancer (extracted from patent WO2015049535A1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1693731-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144867. | |
| CCT245737 | CCT245737 is an orally bioactive CHK1 inhibitor (IC50 of 1.4 nM), displaying >1,000-fold selectivity against CHK2 and CDK1. It potently inhibits cellular CHK1 activity (IC50 30-220nM) and enhances gemcitabine and SN38 cytotoxicity in multiple human tumor cell lines and human tumor xenograft models. It causes inhibition of tumor growth in an Eμ-Myc mouse model of human B-cell lymphocytic leukemia. Synonyms: CCT-245737; CCT 245737; CCT245737; 5-[(4-{[(2R)-morpholin-2-ylmethyl]amino}-5-(trifluoromethyl)pyridin-2-yl)amino]pyrazine-2-carbonitrile. CAS No. 1489389-18-5. Molecular formula: C16H16F3N7O. Mole weight: 379.347. | |
| CCT245737 | CCT245737 (SRA737) is an orally active and seletive Chk1 inhibitor, with an IC50 of 1.3 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SRA737. CAS No. 1489389-18-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18958. | |
| CCT245737(S) | CCT245737, a nitrogen heterocycle compound, has been found to be a CHK1 inhibitor that could probable be effective in antineoplastic studies. It is still under Phase I trail for Solid tumours. IC50: 30-220 nM. Synonyms: CCT245737; CCT 245737; CCT-245737; GTPL9187; GTPL 9187; GTPL-9187; 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile. Grade: 98%. CAS No. 1489389-23-2. Molecular formula: C16H16F3N7O. Mole weight: 379.14. | |
| CCT251236 | CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction. Uses: Scientific research. Group: Signaling pathways. CAS No. 1693731-40-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101026. | |
| CCT-251236 | CCT-251236 is an orally active Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen, which exhibited efficacy in a human ovarian carcinoma xenograft model. Uses: The potential treatment of ovarian carcinoma. Synonyms: CCT251236; CCT 251236; N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide; N-[5-(2,3-dihydro-1,4-benzodioxine-6-amido)-2-methylphenyl]-2-[2-(pyrrolidin-1-yl)ethoxy]quinoline-6-carboxamide; 6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-. Grade: ≥95%. CAS No. 1693731-40-6. Molecular formula: C32H32N4O5. Mole weight: 552.62. | |
| CCT251545 | CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the human Mediator complex-associated protein kinases CDK8 and CDK19 over 291 other kinases. IC50: Synonyms: 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneCCT251545; CCT 251545; CCT-251545; CHEMBL34082138-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one8-{3-Chloro-5-[4-(1-Methyl-1h-Pyrazol-4-Yl)ph. CAS No. 1661839-45-7. Molecular formula: C23H24ClN5O. Mole weight: 421.92. | |
| CCT251545 | CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells[1]. CCT251545 is a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1661839-45-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12681. | |
| CCT-251921 | CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1607837-31-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19984. | |
| CCT-251921 | CCT-251921 has been found to be a CDK inhibitor that could be significant in the studies of colorectal cancer. Synonyms: CCT251921; CCT-251921; CCT 251921; 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one. Grade: 98%. CAS No. 1607837-31-9. Molecular formula: C21H23ClN6O. Mole weight: 410.91. | |
| CCT374705 | CCT374705 is an orally active BCL6 inhibitor with potent antiproliferative effects in vitro. CCT374705 effectively inhibits tumor growth in a lymphoma xenograft mouse model [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2640647-90-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153521. | |
| CCTA-1523 | CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor with anticancer activity. It selectively reverses ABCG2-mediated MDR in cancer cells. Synonyms: Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-; 2,2-Dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)acetamide. Grade: ≥95%. CAS No. 1616271-41-0. Molecular formula: C16H15Cl2NO3. Mole weight: 340.20. | |
| CCVJ | CCVJ. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9-(2-Carboxy-2-cyanovinyl)julolidine,(2E)-2-Cyano-3-(2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-9-yl)acrylicacid. Product Category: Other Fluorophores. Appearance: Red crystalline powder. CAS No. 142978-18-5. Molecular formula: C16H16N2O2. Mole weight: 268.31. Purity: 97%+. IUPACName: (E)-3-(1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13)-trien-7-yl)-2-cyanoprop-2-enoicacid. Canonical SMILES: C1CC2=CC(=CC3=C2N(C1)CCC3)/C=C(\C#N)/C(=O)O. Product ID: ACM142978185-2. Alfa Chemistry ISO 9001:2015 Certified. Categories: CCJO René Cassin. | |
| CCX140-B | CCX140-B is a potent CCR2 antagonist. Synonyms: CCX140; Ilacirnon. CAS No. 1100318-47-5. Molecular formula: C20H13ClF3N5O3S. Mole weight: 495.9. | |
| C-Cys-Mel | C-Cys-Mel. Synonyms: Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-Cys. | |
| CD111/Nectin-1/PVRL1 human | recombinant, expressed in HEK 293 cells, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| CD12681 | CD12681 is a potent and selective RORγ inverse agonist with IC50 of 19 nM. CD12681 was indentified as a preclinical candidate for the topical treatment of psoriasis. Synonyms: N-(2,4-Dimethylphenyl)-N-isobutyl-2-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonamide. Grade: 99%. CAS No. 1952239-59-6. Molecular formula: C25H33N3O4S. Mole weight: 471.61. | |
| CD147 human | recombinant, expressed in HEK 293 cells, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
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