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| Product | Description | |
|---|---|---|
| c-di-2'-dAMP | c-di-2'-dAMP is an analogue of c-diAMP, the bacterial second messenger. Synonyms: 2'- Deoxy- cyclic diadenosine monophosphate, sodium salt. Grade: ≥ 95% by HPLC. Molecular formula: C20H24N10O11P2 (free acid). Mole weight: 642.4 (free acid). |  |
| c-di-2'-dGMP | c-di-2'-dGMP is an analogue of c-diGMP, the bacterial second messenger, which can be used to study ligand-receptor interactions. Synonyms: 2'- Deoxy- cyclic diguanosine monophosphate, sodium salt. Grade: ≥ 95% by HPLC. CAS No. 132182-18-4. Molecular formula: C20H24N10O13P2 (free acid). Mole weight: 674.4 (free acid). | |
| c-di-AMP | c-di-AMP is an agonist of stimulator of interferon genes (STING) for treating cancer. It is a second messenger in bacteria and archaea that is involved in the maintenance of osmotic pressure, response to DNA damage, and control of central metabolism, biofilm formation, acid stress resistance, and other functions. Synonyms: Cyclic diadenylate monophosphate; Cyclic diadenylate; Adenylic acid, cyclic ester; 3',5'-Cyclic diadenylic acid; Cyclic di-3',5'-adenylate; Cyclic di-AMP; Cyclic-di-AMP; Cyclic diadenosine monophosphate; (2R,3R,3aS,7aR,9R,10R,10aS,14aR)-2,9-bis(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxyoctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine 5,12-dioxide. Grade: ≥95%. CAS No. 54447-84-6. Molecular formula: C20H24N10O12P2. Mole weight: 658.41. | |
| c-di-AMP diammonium | c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium; 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide, diammonium; Adenylic acid, cyclic ester diammonium; 3',5'-Cyclic diadenylic acid diammonium; Cyclic di-3',5'-adenylate diammonium; Cyclic diadenylate monophosphate diammonium; (2R,3R,3aS,7aR,9R,10R,10aS,14aR)-2,9-bis(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxyoctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine 5,12-dioxide diammonium. Grade: ≥95%. Molecular formula: C20H30N12O12P2. Mole weight: 692.47. | |
| c-di-AMP disodium | c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4]. Uses: Scientific research. Group: Natural products. Alternative Names: Cyclic diadenylate disodium; Cyclic-di-AMP disodium. CAS No. 2734909-87-4. Pack Sizes: 10 mM * 1 mL; 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12326A. |  |
| c-di-AMP disodium | c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. It activates STING-dependent IFN-β production in mouse and human cells. Synonyms: 3',5'-Cyclic diadenylic acid sodium salt; Cyclic diadenylate disodium; Cyclic-di-AMP disodium; 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide, disodium; Adenylic acid, cyclic ester disodium; 3',5'-Cyclic diadenylic acid disodium; Cyclic di-3',5'-adenylate disodium; Cyclic diadenylate monophosphate disodium. CAS No. 2734909-87-4. Molecular formula: C20H22N10Na2O12P2. Mole weight: 702.38. | |
| c-di-AMP sodium | c-di-AMP sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. Synonyms: Cyclic diadenylate sodium; Cyclic-di-AMP sodium; 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide, sodium; Adenylic acid, cyclic ester sodium; 3',5'-Cyclic diadenylic acid sodium; Cyclic di-3',5'-adenylate sodium; Cyclic diadenylate monophosphate sodium. Grade: ≥95%. Molecular formula: C20H24N10O12P2.xNa. Mole weight: 658.41 (free acid). | |
| CDIBA | CDIBA is a potent and selective cytosolic phospholipase A2 (cPLA2) inhibitor. Synonyms: 4-[2-(1-benzhydryl-5-chloro-2-methylindol-3-yl)ethoxy]benzoic acid. Grade: 99%. CAS No. 479422-22-5. Molecular formula: C31H26ClNO3. Mole weight: 496. | |
| c-Di-GMP | c-diGMP is a bacterial second messenger and a STING ligand. Synonyms: 3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide; 5GP-5GP; Cyclic di-3',5'-guanylate; Cyclic diguanylate; Cyclic diguanylate monophosphate; Cyclic-di-GMP; cGpGp; Cyclic diguanylic acid; cdiGMP; 3',5'-Cyclic diguanylic acid; c-(Gpgp); Bis(3',5')-cyclic diguanylic acid. Grade: ≥95%. CAS No. 61093-23-0. Molecular formula: C20H24N10O14P2. Mole weight: 690.41. | |
| c-di-GMP Fluorinated | A STING agonist. CAS No. 1334145-18-4. Molecular formula: C20H20F2N10O12P2.2Na. Mole weight: 738.36. | |
| c-di-IMP | c-diIMP is an analogue of c-diAMP and c-diGMP, the bacterial second messengers, which is potentially used as an adjuvant for mucosal vaccination. Synonyms: Cyclic diinosine monophosphate; 3'-Inosinic acid, inosinylyl-(3'→5')-, cyclic nucleotide; Cyclic-di-IMP; 3',3'-Cdimp; 9,9'-((2R,3R,3aS,7aR,9R,10R,10aS,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine-2,9-diyl)bis(1,9-dihydro-6H-purin-6-one). Grade: ≥95% by HPLC. CAS No. 79940-41-3. Molecular formula: C20H22N8O14P2. Mole weight: 660.38. | |
| C-DIM12 | C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Synonyms: C-DIM 12; C-DIM-12. Grade: 98%. CAS No. 178946-89-9. Molecular formula: C23H17ClN2. Mole weight: 356.85. | |
| C-DIM12 | C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DIM-C-pPhCl. CAS No. 178946-89-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19808. | |
| C-DIM12 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| c-di-UMP | A STING agonist negative control. Synonyms: Cyclic di-uridine monophosphate, c-di-UMP sodium salt. CAS No. 73120-97-5. Molecular formula: C18H20N4O16P2.2Na. Mole weight: 656.3. | |
| CDK12-IN-2 | CDK12-IN-2, a potent and selective nanomolar CDK12 inhibitor (IC50 = 52 nM) with good physicochemical properties, inhibits phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II, and can be used as an excellent chemical probe for the study of CDK12 function. It is also a strong CDK13 inhibitor because CDK13 is the closest homologue of CDK12. It shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. Synonyms: Urea, N-[trans-4-[(5-cyano-2-pyridinyl)amino]cyclohexyl]-N-[4-(1,6-dihydro-1-methyl-6-oxo-3-pyridinyl)phenyl]-N'-(phenylmethyl)-; 3-Benzyl-1-(trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)urea. CAS No. 2244987-03-7. Molecular formula: C32H32N6O2. Mole weight: 532.64. | |
| CDK12-IN-4 | CDK12-IN-4 is a pyrazolotriazine that is a potent inhibitor of CDK12 with an IC50 of 0.641 μM at high ATP (2 mM). At high ATP (2 mM), it has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM). (WO2021116178A1). Synonyms: Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-cyclopropyl-N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-. CAS No. 2651196-69-7. Molecular formula: C20H20F2N8O. Mole weight: 426.42. | |
| CDK12-IN-5 | CDK12-IN-5 is a pyrazolotriazine that is a potent inhibitor of CDK12 with an IC50 of 23.9 nM at high ATP (2 mM). At high ATP (2 mM), it has no effect on CDK2/Cyclin E (IC50 = 173 μM) and CDK9/Cyclin T1 (IC50 = 127 μM). (WO2021116178A1). Synonyms: Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, N-[(6,7-difluoro-1H-benzimidazol-2-yl)methyl]-2-(4-morpholinyl)-8-(trifluoromethyl)-. CAS No. 2651200-35-8. Molecular formula: C18H15F5N8O. Mole weight: 454.36. | |
| CDK12-IN-6 | CDK12-IN-6 is a pyrazolotriazine that is a potent inhibitor of CDK12 with an IC50 of 1.19 μM at high ATP (2 mM). At high ATP (2 mM), it has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM). (WO2021116178A1). Synonyms: 8-cyclopropyl-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-(piperazin-1-yl)pyrazolo[1,5-a][1,3,5]triazin-4-amine. CAS No. 2651196-71-1. Molecular formula: C20H21F2N9. Mole weight: 425.44. | |
| Cdk1/2 Inhibitor III | Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 of 2.1 μM for CDK1/cyclin B. It is a cell-permeable triazolo-diamine compound with anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa and A375 cells, respectively). Synonyms: Cyclin-dependent Kinase 1/2 Inhibitor III; 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-; 3-Amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide; 3-amino-N-(2,6-difluorophenyl)-5-((4-sulfamoylphenyl)amino)-1H-1,2,4-triazole-1-carbothioamide. Grade: >95%. CAS No. 443798-55-8. Molecular formula: C15H13F2N7O2S2. Mole weight: 425.44. | |
| Cdk1/2 Inhibitor III - CAS 443798-55-8 | The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 | The Cdk1/2 Inhibitor II, NU6102, also referenced under CAS 444722-95-6, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk1/5 Inhibitor - CAS 40254-90-8 | The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK1/CyclinA1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK1/Cyclin A2, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK1/CyclinB1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK1 Inhibitor | Cdk1 inhibitor is a cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties with IC50 of 2 μM. Cdk1 inhibitor acts as a selective and ATP-competitive inhibitor of Cdk1/cyclin B with IC50 of 5.8 μM. It also inhibits Cdk5 with IC50 of 25 μM. Synonyms: Cyclin-dependent Kinase 1 Inhibitor. Grade: ≥95%. CAS No. 220749-41-7. Molecular formula: C17H11ClN2O. Mole weight: 294.7. | |
| Cdk1 Inhibitor - CAS 220749-41-7 | The Cdk1 Inhibitor, also referenced under CAS 220749-41-7, controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk1 Inhibitor IV, RO-3306 | RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| cdk1, phosphorylated (Thr14, Tyr15) Negative Control Peptide (Non-Phosphorlyated) | cdk1, phosphorylated (Thr14, Tyr15) Negative Control Peptide (Non-Phosphorlyated). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x100ug. US Biological Life Sciences. |  Worldwide |
| cdk1, phosphorylated (Thr14, Tyr15) Positive Control Peptide (Phosphorlyated) | cdk1, phosphorylated (Thr14, Tyr15) Positive Control Peptide (Phosphorlyated). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x100ug. US Biological Life Sciences. | Worldwide |
| CDK2 | CDK2 is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S 0 /T 0 ) in a protein substrate. Uses: Scientific research. Group: Peptides. CAS No. 255064-79-0. Pack Sizes: 5 mg. Product ID: HY-P0235. | |
| CDK2 | CDK2, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. Synonyms: Cell division protein kinase 2; kinase Cdk2; p33 protein kinase; Anti-Gastric receptor I; Anti-H2R; His-His-Ala-Ser-Pro-Arg-Lys; L-histidyl-L-histidyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-lysine. Grade: ≥95%. CAS No. 255064-79-0. Molecular formula: C35H57N15O9. Mole weight: 831.92. | |
| Cdk2/9 Inhibitor | Cdk2/9 inhibitor is an inhibitor used for the synthesis of Nek1 inhibitors BSc5231 and BSc5367. Synonyms: CK7; 4-(2-Amino-4-methyl-5-thiazolyl)-N-(3-nitrophenyl)-2-pyrimidinamine; [4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine; 4-(2-Amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)-2-pyrimidinamine. Grade: 95%. CAS No. 507487-89-0. Molecular formula: C14H12N6O2S. Mole weight: 328.34. | |
| Cdk2/9 Inhibitor - CAS 507487-89-0 | The Cdk2/9 Inhibitor, also referenced under CAS 507487-89-0, controls the biological activity of Cdk2/9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2 acetate | CDK2 acetate, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. Synonyms: H-His-His-Ala-Ser-Pro-Arg-Lys-OH.CH3CO2H; L-histidyl-L-histidyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-lysine acetic acid. Grade: ≥95%. Molecular formula: C37H61N15O11. Mole weight: 891.99. | |
| CDK2/CyclinA1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2/Cyclin A2, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2/CyclinE1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2 degrader 1 | CDK2 degrader 1 (Compound 3) is a selective CDK2 molecular glue degrader with a Dmax (CDK2) of > 80% and a Ki (CRBN) > 1 ?M. CDK2 degrader 1 binds to cereblon to induce ubiquitination and subsequent proteasomal degradation of the CDK2. CDK2 degrader 1 is used in the research of a wide range of cancers[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3036604-59-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-163814. | |
| CDK2, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2-IN-30 | CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC 50 value ≤20 nM. CDK2-IN-30 can be used in tumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2640038-22-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164664. | |
| CDK2-IN-4 | CDK2-IN-4 (compound 73) is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2079895-42-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117535. | |
| CDK2-IN-7 | CDK2-IN-7 is a cyclin-dependent kinases 2 (CDK2) inhibitor (IC50 <50 nM) for the treatment of cancer. Synonyms: Benzenesulfonamide, 4-[[7'-[(1R,2S)-2-hydroxy-2-methylcyclopentyl]-6'-oxospiro[cyclopropane-1,5'-[5H]pyrrolo[2,3-d]pyrimidine]-2'(7'H)-yl]amino]-N-(3-methyl-3-azetidinyl)-, rel-; 4-[[7'-[(1R,2S)-2-hydroxy-2-methylcyclopentyl]-6'-oxospiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidine]-2'-yl]amino]-N-(3-methylazetidin-3-yl)benzenesulfonamide. CAS No. 2498658-13-0. Molecular formula: C24H30N6O4S. Mole weight: 498.60. | |
| CDK2-IN-73 | CDK2-IN-73 is a potent and selective inhibitor of CDK2 with IC50 of 44 nM for CDK2. Synonyms: CDK2 inhibitor 73; CDK2-IN-4. CAS No. 2079895-42-2. Molecular formula: C23H18N6O2S. Mole weight: 442.49. | |
| CDK2 inhibitor II | CDK2 inhibitor II. Group: Biochemicals. Alternative Names: 4- [2- (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazinyl] benzenesulfonamide; 4- [ (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazino] benzenesulfonamide; SC 221409. Grades: Highly Purified. CAS No. 222035-13-4. Pack Sizes: 5mg. Molecular Formula: C14H11BrN4O3S, Molecular Weight: 395.23. US Biological Life Sciences. | Worldwide |
| CDK2 Inhibitor II | The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2. It is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 with IC50 of 60 nM. Synonyms: Cyclin-dependent kinase 2 Inhibitor II; SC-221409. Grade: ≥95%. CAS No. 222035-13-4. Molecular formula: C14H11BrN4O3S. Mole weight: 395.2. | |
| Cdk2 Inhibitor II - CAS 222035-13-4 | The Cdk2 Inhibitor II, also referenced under CAS 222035-13-4, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk2 Inhibitor III - CAS 199986-75-9 | The Cdk2 Inhibitor III, also referenced under CAS 199986-75-9, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK3/CyclinE1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/6/1 Inhibitor | CDK4/6/1 Inhibitor is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively. It is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1. Synonyms: 5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indol]-5'-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine; 2-Pyrimidinamine, 5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-[3H]indol]-5'-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-. Grade: ≥96%. CAS No. 2099128-41-1. Molecular formula: C28H30F2N6. Mole weight: 488.57. | |
| CDK4/6-IN-15 | CDK4/6-IN-15 is an orally active and selective CDK4/6 inhibitor. CDK4/6-IN-15 potently inhibits cancer cells growth. CDK4/6-IN-15 arrests cell cycle at G1 phase and suppresses retinoblastoma tumour suppressor protein (Rb) phosphorylation at S780 and E2 factor (E2F)-regulated gene expression [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2078047-99-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142076. | |
| CDK4/6-IN-2 | CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM, respectively. (Extracted from patent US20180000819A1, Compound 1). Synonyms: 5-[(4-Ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzimidazol-6-yl)-2-pyridinyl]-2-pyrimidinamine; 2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]-. Grade: ≥97%. CAS No. 1800506-48-2. Molecular formula: C27H32F2N8. Mole weight: 506.59. | |
| CDK4/6-IN-3 | CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 and 2.2 nM, respectively. It can be used for the treatment of glioblastoma. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. Synonyms: 2-Pyrimidinamine, N-[5-(6-ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-5,6,7,8-tetrahydro-4-methyl-4H-pyrazolo[1,5-a]azepin-3-yl]-; N-[5-(6-Ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]-2-pyrimidinamine. Grade: ≥97%. CAS No. 2366237-37-6. Molecular formula: C25H31FN8. Mole weight: 462.57. | |
| CDK4/6-IN-5 | CDK4/6-IN-5 is a potent inhibitor of CDK4 and CDK6 with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (Extracted from patent WO2019207463A1, example A93). Synonyms: 1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)-. Grade: 96%. CAS No. 2380321-50-4. Molecular formula: C22H28ClFN6O4S. Mole weight: 527.01. | |
| CDK4/6 Inhibitor IV | Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine inhibitor for Cdk4/cyclin D1 with IC50 values of 1.5 μM and Cdk6/cyclin D1 with IC50 values of 5.6 μM. It exhibits blocking of pRb phosphorylation at Ser780 and Ser795. Cdk4/6 inhibitor IV can suppresses tumor growth in Xenograft mouse model. Synonyms: CINK4; Cyclin-dependent kinase 4/6 Inhibitor IV. Grade: ≥98%. CAS No. 359886-84-3. Molecular formula: C27H32N6O. Mole weight: 456.6. | |
| Cdk4/6 Inhibitor IV - CAS 359886-84-3 | The Cdk4/6 Inhibitor IV, also referenced under CAS 359886-84-3, controls the biological activity of Cdk4/6. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/Cyclin D1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/Cyclin D1 active human | recombinant, expressed in baculovirus infected Sf9 cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/CyclinD3, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4-IN-1 | CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer. Synonyms: CDK4 IN 1; LEE011 analog; CDK4-IN-1; CDK4IN-1; CDK4-IN1; CDK4IN1; CDK4 IN 1; 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine. Grade: >98%. CAS No. 1256963-02-6. Molecular formula: C22H29ClN8. Mole weight: 440.97. | |
| CDK4 Inhibitor | Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 of 0.8 μM. It also inhibits the activity of other Cdk's only at much higher concentrations (IC50 = 520 nM and 2.1 μM for Cdk2/E and Cdk1/B, respectively). Cdk4 inhibitor can inhibit tumor cells growth in HCT-116 and NCI-H460 cells (IC50 < 3.0 μM). Synonyms: 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. Grade: ≥90%. CAS No. 546102-60-7. Molecular formula: C20H10BrN3O2. Mole weight: 404.22. | |
| Cdk4 Inhibitor III - CAS 265312-55-8 | The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 | The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk4 Inhibitor V (4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione) | A cell-permeable pyridinylmethylamino-isoquinoline dione compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of Cdk4/D1 activity with selectivity over Cdk2/E and Cdk1/B (IC50=0.03, 1.6 and 25.3uM, respectively). Shown to block the phosphorylation of Rb and induce growth arrest in HCT116 and MCF-7 cells (IC50=0.73 and 0.88uM). Displays desirable metabolic stability in rat liver microsomes and in the presence of NADPH and UDPGA cofactors (t1/2 > 30mins). Group: Biochemicals. Grades: Highly Purified. CAS No. 943746-57-4. Pack Sizes: 5mg. Molecular Formula: C??H??IN?O?. US Biological Life Sciences. | Worldwide |
| Cdk4 Inhibitor V - CAS 943746-57-4 | The Cdk4 Inhibitor V, also referenced under CAS 943746-57-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4-R24C (23-32) | CDK4-R24C (23-32) is a peptide derived from CDK4-R24C. The common mutation in CDK4 (CDK4R24C) in melanoma inhibits the interaction with p16INK4A and thus leads to constitutive activation. | |
| CDK5-IN-1 | CDK5-IN-1 is a potent CDK5 inhibitor with an activity of less than 10 nM against CDK5. It is used in kidney diseases research. Synonyms: 1H-Pyrazole-3-methanol, 1-[3-fluoro-4-[[2-[(1-methyl-4-piperidinyl)sulfonyl]-1,6-naphthyridin-7-yl]amino]phenyl]-. CAS No. 2639540-19-3. Molecular formula: C24H25FN6O3S. Mole weight: 496.56. | |
| CDK5 inhibitor 20-223 | CDK5 inhibitor 20-223, an effective anti-colorectal cancer (CRC) agent, is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. Synonyms: 2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-; CDK5-IN-20-223; N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-(2-naphthyl)acetamide. Grade: ≥99%. CAS No. 865317-30-2. Molecular formula: C19H19N3O. Mole weight: 305.37. | |
| CDK5/p25, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
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