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| Product | Description | |
|---|---|---|
| CB-403 | CB-403, a cinnamaldehyde derivative, which has antitumor effect through the arrest of cell cycle progression in the G2/M phase. Uses: Antitumor effect through the arrest of cell cycle progression in the g2/m phase. Synonyms: CB-403; CB403; CB 403; UNII-4V9Q0C88UK. 2-Propenal, 3-[2-[(2-methylphenyl)?methoxy]?phenyl]?-, (2E)?-. Grade: ≥96%. CAS No. 302356-18-9. Molecular formula: C17H16O2. Mole weight: 252.11. |  |
| CB5083 | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models. CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. Synonyms: CB5083; CB-5083; CB 5083. Grade: >98%. CAS No. 1542705-92-9. Molecular formula: C24H23N5O2. Mole weight: 413.4. | |
| CB-5083 | CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC50 of 11 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1542705-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12861. |  |
| CB-52 | Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. Anandamide (AEA), also known as N-arachidonoylethanolamine, is an endogenous lipid with cannabinergic activity. CB-52 is a stable analog of Δ9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 210 and 30 nM, respectively. Synonyms: CB52; CB 52. Grade: ≥98%. CAS No. 869376-90-9. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB-5339 | CB-5339 is an oral activity potent p97 inhibitor with an IC50 <30 nM. CB-5339 can be used for leukemia research[1]. CB-5339 extracted from WO2015109285A1 compound FF07. Uses: Scientific research. Category: Signaling pathways. CAS No. 1863952-15-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128724. | |
| CB 65 | CB 65 is a high affinity and selective CB2 receptor agonist with Ki of 3.3 nM for CB2 receptor and Ki of > 1000 nM for CB1 receptor. Uses: Cannabinoid receptor agonists. Synonyms: N-Cyclohexyl-7-chloro-1-[2-(4-morpholinyl)ethyl]quinolin-4(1H)-one-3-carboxamide. Grade: ≥99%. CAS No. 913534-05-1. Molecular formula: C22H28ClN3O3. Mole weight: 417.93. | |
| CB-6644 | CB-6644 is a novel allosteric selective inhibitor of the ruvbl1/2 complex with anti-cancer activity. It blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM. Synonyms: CB 6644; CB6644. CAS No. 2316817-88-4. Molecular formula: C29H34ClFN4O5. Mole weight: 573.06. | |
| CB-6644 | CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2316817-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114429. | |
| CB7646 | CB7646 is a stable analogue of trimelamol (TM). It is used as an anti-tumour agent. Uses: Cb7646 is used as an anti-tumour agent. Synonyms: CB-7646; CB 7646; CB7646; UNII-LYO93N5MEB. Methanol, ((6-(methylamino)-1,3,5-triazine-2,4-diyl)bis(methylimino))bis-; [[4-[Hydroxymethyl(methyl)amino]-6-(methylamino)-1,3,5-triazin-2-yl]-methylamino]methanol. Grade: >98 %. CAS No. 104880-54-8. Molecular formula: C8H16N6O2. Mole weight: 228.25. | |
| CB-7921220 | CB-7921220 is an adenylate cyclase inhibitor which is selective, reducing adenylyl cyclase type I and VI activity by 60% while having no effect on types II and V in Sf9 membranes stimulated by forskolin at a concentration of 100 μM. CB-7921220 has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6. Synonyms: CB7921220; CB 7921220; CB-7921220; 6-[(E)-2-(4-aminophenyl)ethenyl]pyridine-2-carboxylic acid. CAS No. 115453-99-1. Molecular formula: C14H12N2O2. Mole weight: 240.26. | |
| CB7993113 | CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 819827-50-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111450. | |
| CB-839 | CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). ( ). Synonyms: CB-839; CB839; CB 839. Grade: 98%. CAS No. 1439399-58-2. Molecular formula: C26H24F3N7O3S. Mole weight: 571.57. | |
| CB-86 | Cannabinoid receptors (CB) are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. CB-86 is a resorcinol-anandamide hybrid compound that acts as a partial agonist for the CB1 receptor with Ki of 5.6 nM and a neutral antagonist for CB2 receptor with Ki of 7.9 nM. CB-86 exhibits antinociceptive effects in mice treated with formalin. Synonyms: CB86; CB 86. Grade: ≥98%. CAS No. 1150586-64-3. Molecular formula: C26H43NO3. Mole weight: 417.6. | |
| CB 966 | CB 966 is a novel analogues of 1,25-dihydroxyvitamin D3 and it was found to significantly delay the rejection of allogeneic skin grafts in CBA (H-2k) recipient mice. Synonyms: CB 966; CB966; CB-966. (1R-(1alpha(R*),3abeta,4E(1R*,3S*,5Z),7aalpha))-5-((1-(6-ethyl-6-hydroxy-1-methyloctyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-Cyclohexanediol. Grade: 98%. CAS No. 128312-71-0. Molecular formula: C30H50O3. Mole weight: 458.72. | |
| CBA | Transient Receptor Potential Cation Channel Subfamily M Member 4 (TRPM 4) is a Protein Coding gene. Diseases associated with TRPM4 include Progressive Familial Heart Block, Type Ib and Erythrokeratodermia Variabilis Et Progressiva. TRPM4-IN-5 is a potent and selective inhibitor of the cation channel TRPM4 blocker with IC 50 of 1.5 μM. Synonyms: 4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid; TRPM4-IN-5; TRPM4IN-5; TRPM4-IN5; TRPM4 IN-5. Grade: ≥98%. CAS No. 351424-20-9. Molecular formula: C15H11Cl2NO4. Mole weight: 340.16. | |
| CBB1003 | CBB1003, a piperazine derivative, has been found to be a histone demethylase LSD1 inhibitor that could restrain the proliferation and colony formation of CRC cell in mice. IC50: 10.54 uM. Uses: Cbb1003 has been found to be a histone demethylase lsd1 inhibitor that could restrain the proliferation and colony formation of crc cell in mice. Synonyms: CBB1003; SCHEMBL16273292; CS-3476. Grade: 98%. CAS No. 1379573-88-2. Molecular formula: C25H31N9O4. Mole weight: 521.57. | |
| CBB1003 hydrochloride | CBB1003 hydrochloride is an inhibitor of histone demethylase LSD1 with an IC50 of 10.54 μM. Synonyms: 4-(3-{[4-(4-Carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-nitrobenzyl)-1-piperazinecarboximidamide pentahydrochloride; 1-Piperazinecarboximidamide, 4-[[3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-nitrophenyl]methyl]-, hydrochloride (1:5). Molecular formula: C25H36Cl5N9O4. Mole weight: 703.88. | |
| CBB1007 | CBB1007, an amidino-guanidinium derivative, has been found to have biological activity in anticancer-study by acting as a LSD1 inhibitor. IC50: 5.27 uM. Uses: Cbb1007 has been found to have biological activity in anticancer-study by acting as a lsd1 inhibitor. Synonyms: CBB1007; SCHEMBL16273312; CS-1737. Grade: 98%. CAS No. 1379573-92-8. Molecular formula: C27H34N8O4. Mole weight: 534.61. | |
| CBB1007 hydrochloride | CBB1007 hydrochloride, a cell-permeable amidino-guanidinium compound, is a potent, reversible and substrate competitive LSD1 selective inhibitor with an IC50 of 5.27 μM for hLSD1. Synonyms: Methyl 3-{[4-(4-carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-[(4-carbamimidoyl-1-piperazinyl)methyl]benzoate pentahydrochloride; Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester, hydrochloride (1:5). Grade: ≥98%. Molecular formula: C27H39Cl5N8O4. Mole weight: 716.91. | |
| CBB1007 trihydrochloride | CBB1007 trihydrochloride, a cell-permeable amidino-guanidinium compound, is a potent, reversible and substrate competitive LSD1 selective inhibitor with an IC50 of 5.27 μM for hLSD1. Synonyms: Methyl 3-{[4-(4-carbamimidoylbenzoyl)-1-piperazinyl]carbonyl}-5-[(4-carbamimidoyl-1-piperazinyl)methyl]benzoate trihydrochloride; Benzoic acid, 3-[[4-[4-(aminoiminomethyl)benzoyl]-1-piperazinyl]carbonyl]-5-[[4-(aminoiminomethyl)-1-piperazinyl]methyl]-, methyl ester, hydrochloride (1:3). Grade: ≥96%. Molecular formula: C27H37Cl3N8O4. Mole weight: 643.99. | |
| CBD-1 | CBD-1 is isolated from Canis lupus. It has antibacterial and antifungal activity. | |
| CBFβ Inhibitor | Core binding factors (CBFs) are heterodimeric transcription factors containing a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBFβ Inhibitor cellular studies indicate a good correlation between the inhibitor's antiproliferative activity and the Runx1 expression level in the target cells. Synonyms: Core Binding Factor-β Inhibitor; 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-; 5-Ethyl-4-(4-methoxyphenyl)-2-thiazolamine; Sc 221405; 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine. Grade: ≥98%. CAS No. 493028-20-9. Molecular formula: C12H14N2OS. Mole weight: 234.32. | |
| CBHA | Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. CBHA is a cell-permeable second generation hybrid polar agent that acts as a HDAC inhibitor. It exhibits ID50 values of 0.01 and 0.07 μM in vitro for HDAC1 and HDAC3, respectively. CBHA also induces apoptosis in nine different neuroblastoma cell lines in culture. Uses: Histone deacetylase inhibitors. Synonyms: Histone Deacetylase Inhibitor II; m-Carboxycinnamic acid bis-hydroxamide. Grade: ≥98%. CAS No. 174664-65-4. Molecular formula: C10H10N2O4. Mole weight: 222.2. | |
| c-Bicyclo[2.2.1]hept-2-yl-methylamine hydrobromide | c-Bicyclo[2.2.1]hept-2-yl-methylamine hydrobromide. Alternative Names: 2-Aminomethylnorbornane; Norbornylmethylamine; 2-Aminomethyl-bicyclo<2,2,1>heptan; 2-Norbornanemethylamine. CAS No. 14370-50-4. Purity: 96%. Product ID: ACM14370504. Molecular formula: C8H16BrN. Mole weight: 206.13. IUPAC Name: 3-bicyclo[2.2.1]heptanylmethanamine. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| CBiPES | CBiPES is a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM. CBiPES attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity. CBiPES can be used for research of neurological diseases, such as Parkinson's disease (PD)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 353235-01-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107505A. | |
| CBiPES hydrochloride | CBiPES hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 856702-40-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| CBiPES hydrochloride | CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Synonyms: N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride. Grade: ≥99% by HPLC. CAS No. 856702-40-4. Molecular formula: C21H19N3O2S.HCl. Mole weight: 413.92. | |
| CBL0137 | CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 μM and inhibits NF-κB with an EC50 of 0.47 μM. It also inhibits histone chaperone FACT (facilitates chromatin transcription) and MYC signal. Synonyms: CBL0137; CBL-0137; CBL 0137; CBLC137; CBLC-137; CBLC 137; Curaxin 137; 1,1'-(9-(2-(Isopropylamino)ethyl)-9H-carbazole-3,6-diyl)diethanone; 1-[6-acetyl-9-[2-(propan-2-ylamino)ethyl]carbazol-3-yl]ethanone. CAS No. 1197996-80-7. Molecular formula: C21H24N2O2. Mole weight: 336.435. | |
| CBL0137 | CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF-κB and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Curaxin 137; CBL-C137. CAS No. 1197996-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935. | |
| CBL0137 hydrochloride | CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Curaxin-137 hydrochloride; CBL-C137 hydrochloride. CAS No. 1197397-89-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18935A. | |
| CBL0137 hydrochloride | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CBL0137 activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It functionally inactivates the facilitates chromatin transcription complex, driving the effects on p53 and NF-κB and promoting cancer cell death. Synonyms: CBLC137; CBL-0137; Curaxin 137. Grade: ≥98%. CAS No. 1197397-89-9. Molecular formula: C21H24N2O2·HCl. Mole weight: 372.9. | |
| CBL0137 Hydrochloride | CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex). Group: Inhibitors. Alternative Names: CBLC137 HCl, Curaxin 137 HCl. CAS No. 1197397-89-9. Pack Sizes: 5mg. Product ID: S8483. Formula: C21H24N2O2.HCl. Smiles: CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| Cbl-b-IN-1 | Cbl-b-IN-1 (Example 519) is an inhibitor of Cbl-b, with an IC50 of less than 100 nM. Cbl-b-IN-1 can promote the secretion of cytokines such as IL-2, IFN-γ, and TNF-α, facilitate T cell activation, and enhance the TCR signaling pathway. Cbl-b-IN-1 can be used in research on immunomodulation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2368841-84-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136339. | |
| Cbl-b-IN-10 | Cbl-b-IN-10 is a Cbl-b and c-Cbl inhibitor with IC50 values of 6.0 nM and 3.5 nM, respectively. Cbl-b-IN-10 can be used in the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2815225-12-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156766. | |
| Cbl-b-IN-3 | Cbl-b-IN-3 inhibits proto-oncogene-B (CPL-B). CBL-B is an E3 ubiquitin ligase that ubiquitinates proteins downstream of immune receptors to downregulate positive signaling cascades. Synonyms: 2-{3-[(1S,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one. Grade: >98.0%. CAS No. 2573775-59-2. Molecular formula: C30H34F3N5O. Mole weight: 537.63. | |
| Cbl-b-IN-5 | Cbl-b-IN-5 (compound 6) is a Cbl-b inhibitor (IC50=3-10 μM). Cbl-b-IN-5 has the potential to be used in the study of cancer and related diseases amenable to immune system modulation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2368835-59-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155120. | |
| Cbl-b-IN-9 | Cbl-b-IN-9 (Compound 300) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 5.6 nM and 4.7 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2815223-41-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156765. | |
| CBM 301940 | Malonyl-CoA decarboxylase (MCD) is found from bacteria to humans, which has important roles in regulating fatty acid metabolism and food intake. CBM 301940 is a potent malonyl-CoA decarboxylase (MCD) inhibitor with IC50 of 23 nM. It suppresses malonyl-CoA degradation and fatty acid oxidation in isolated rat hearts, leading to secondary increase in glucose oxidation. Synonyms: (2S,3R,4S)-3-ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-(2-oxoethyl)-2H-pyran-5-carboxylic acid, methyl ester; CBM301940; CBM-301940. Grade: ≥98%. CAS No. 902146-11-6. Molecular formula: C15H20F6N2O5. Mole weight: 422.32. | |
| CBP501 | CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. Synonyms: CBP-501; CBP 501; H-D-Bpa-D-Ser-D-Trp-D-Ser-D-Phe(F5)-D-Cha-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-OH. CAS No. 565434-85-7. Molecular formula: C86H122F5N29O17. Mole weight: 1929.06. | |
| CBP501 Affinity Peptide | CBP501 Affinity Peptide exhibits similarity to part of the human 14-3-3e αC helix, suggesting that CBP501 may bind to this region. Synonyms: H-Asn-Ser-Asp-Cys-Ile-Ile-Ser-Arg-Lys-Ile-Glu-Gln-Lys-Glu-OH; L-Glutamic acid, L-asparaginyl-L-seryl-L-α-aspartyl-L-cysteinyl-L-isoleucyl-L-isoleucyl-L-seryl-L-arginyl-L-lysyl-L-isoleucyl-L-α-glutamyl-L-glutaminyl-L-lysyl-. Grade: ≥95%. CAS No. 1351804-17-5. Molecular formula: C68H119N21O25S. Mole weight: 1662.89. | |
| CBP-93872 | CBP-93872 is a G2 checkpoint inhibitor. CBP-93872 specifically abrogates the DNA double-stranded break (DSB)-induced G2 checkpoint through inhibiting maintenance. CBP-93872 is an inhibitor of maintenance of the DSB-specific G2 checkpoint and thus might be a strong candidate as the basis for a drug that specifically sensitizes p53-mutated cancer cells to DSB-inducing DNA damage therapy. Synonyms: CBP 93872; CBP93872; 1-amino-3-((2-bromo-4-methylphenyl)amino)propan-2-ol. Grade: 98%. CAS No. 67427-51-4. Molecular formula: C10H15BrN2O. Mole weight: 259.14. | |
| CBP-aminomethylenevancomycin | CBP-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP aminomethylenevancomycin. | |
| CBP-C1-aminomethylenevancomycin | CBP-C1-aminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP C1 aminomethylenevancomycin. | |
| CBPD-268 | CBPD-268 is a potent and orally active CBP/p300 PROTAC degrader with an DC50 value of ≤ 0.03 nM. CBPD-268 induces CBP/p300 degradation and inhibits cell growth. CBPD-268 shows antitumor activity. CBPD-268 has the potential for the research of AR-positive prostate cancer (Structure Note: Red, Androgen receptor degrader (HY-W248665A); Blue, CBP/p300 ligand (HY-161483); Black, Linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2832961-58-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-161369. | |
| CBPD-409 | CBPD-409 is an orally active PROTAC degrader for CBP/p300, with DC50 of 0.2-0.4 nM. CBPD-409 exhibits antiproliferative effects in AR+ prostate cancer cell lines VCaP, LNCaP and 22Rv1, with IC50s of 1.2-2.0 nM. CBPD-409 exhibits antitumor efficacy (Red: CBP inhibitor GNE049 (HY-108435); Blue: CRBN/cullin 4A Thalidomide (HY-14658); Black: Linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3037549-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-158113. | |
| CBP/EP300-IN-2 | CBP/EP300-IN-2 is a CBP/EP300 inhibitor with IC50s of 1.07 and 5.96 nM for CBP/HTRF and Myc, respectively. (Extracted from patent WO2017205538A1, example 25). Synonyms: 5H-Pyrazolo[4,3-c]pyridine-5-carboxamide, 3-[6-(difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)-4-isoquinolinyl]-1,4,6,7-tetrahydro-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-; CBP/p300-IN-2; 3-[6-(Difluoromethyl)-7-(1-methyl-1H-pyrazol-4-yl)-4-isoquinolinyl]-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide. Grade: ≥95%. CAS No. 2158265-96-2. Molecular formula: C27H29F2N7O2. Mole weight: 521.56. | |
| CBP-iminomethylenevancomycin | CBP-iminomethylenevancomycin is an analogue of vancomycin which overcomes the drug resistance and induces cell permeability. It significantly increases the antibacterial activity and decreases the side effects. Uses: Antibacterial agent. Synonyms: CBP iminomethylenevancomycin. | |
| CBP/p300-IN-1 | CBP/p300-IN-1 is an inhibitor of CBP/EP300 bromodomain. Synonyms: 2-Methyl-2-propanyl 3-{[(1-acetyl-5-methoxy-1H-indol-3-yl)carbonyl]amino}-4-fluorobenzoate; tert-Butyl 3-(1-acetyl-5-methoxy-1H-indole-3-carboxamido)-4-fluorobenzoate; Benzoic acid, 3-[[(1-acetyl-5-methoxy-1H-indol-3-yl)carbonyl]amino]-4-fluoro-, 1,1-dimethylethyl ester. Grade: ≥95%. CAS No. 2443789-32-8. Molecular formula: C23H23FN2O5. Mole weight: 426.44. | |
| CBP/p300-IN-1 | CBP/p300-IN-1 is a CBP/EP300 bromodomain inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 2443789-32-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111420. | |
| CBP/p300-IN-12 | CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 = 166 nM) and CBP inhibitor that reduces H3K27Ac levels in PC-3 cells (EC50 = 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450. Synonyms: N-(3-(3-((R)-3'-(2-((4-fluorobenzyl)((S)-1,1,1-trifluoropropan-2-yl)amino)-2-oxoethyl)-2',4'-dioxo-2,3-dihydrospiro[indene-1,5'-oxazolidin]-5-yl)ureido)phenyl)acrylamide. Molecular formula: C33H29F4N5O6. Mole weight: 667.61. | |
| CBP/p300-IN-14 | CBP/p300-IN-14 is a potent CBP/EP300 (lysine acetyltransferase) inhibitor with an IC50 of 3.3 nM. (Extracted from patent WO2021213521A1, compound 27). Synonyms: 3-Isoquinolinecarboxamide, 1-[7-(difluoromethyl)-3,4-dihydro-6-(1-methyl-1H-pyrazol-4-yl)-1(2H)-quinolinyl]-N-methyl-6-(4-methyl-2-oxo-1-piperazinyl)-; 1-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-6-(4-methyl-2-oxopiperazin-1-yl)isoquinoline-3-carboxamide. CAS No. 2725036-10-0. Molecular formula: C30H31F2N7O2. Mole weight: 559.61. | |
| CBP/p300-IN-5 | P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase with an IC50 of 18.8 nM. (Extracted from patent WO2016044770A1, Example 715). Synonyms: CBP/p300-IN-5; 2-[4-[(3'R,4S)-3'-fluoro-1-[2-[(4-fluorophenyl)methyl-[(1S)-2,2,2-trifluoro-1-methyl-ethyl]amino]-2-oxo-ethyl]-2,5-dioxo-spiro[imidazolidine-4,1'-indane]-5'-yl]pyrazol-1-yl]-N-methylacetamide; 2-((3'R,4S)-3'-Fluoro-5'-(1-(2-(methylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-2,5-dioxo-2',3'-dihydrospiro[imidazolidine-4,1'-inden]-1-yl)-N-(4-fluorobenzyl)-N-((S)-1,1,1-trifluoropropan-2-yl)acetamide; N-(4-Fluorobenzyl)-2-[(3'R,4S)-3'-fluoro-5'-{1-[2-(methylamino)-2-oxoethyl]-1H-pyrazol-4-yl}-2,5-dioxo-2',3'-dihydro-1H-spiro[imidazolidine-4,1'-inden]-1-yl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]acetamide. Grade: ≥95%. CAS No. 1889284-33-6. Molecular formula: C29H27F5N6O4. Mole weight: 618.55. | |
| CBP/p300-IN-8 | CBP/p300-IN-8, a potent inhibitor of the CBP/P300 family of bromodomains, inhibits CBP and BRD4 activity with IC50s of 0.01-0.1 μM and 1-1000 μM, respectively. Synonyms: 6H-Imidazo[4,5-f]quinoline-6-carboxylic acid, 3-[(1S,3S)-3-carboxycyclohexyl]-3,7,8,9-tetrahydro-7-methyl-2-(phenylmethyl)-, 6-methyl ester, (7S)-; NSC-828853; (1S,3S)-3-[(7S)-2-Benzyl-6-(methoxycarbonyl)-7-methyl-6,7,8,9-tetrahydro-3H-imidazo[4,5-f]quinolin-3-yl]cyclohexanecarboxylic acid. Grade: ≥95%. CAS No. 2304416-91-7. Molecular formula: C27H31N3O4. Mole weight: 461.55. | |
| CBP/p300-IN-8 | CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains. CBP/p300-IN-8 inhibits CBP (IC50=0.01-0.1 μΜ) and BRD4 (IC50=1-1000 μΜ) activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2304416-91-7. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-136920. | |
| CBP/p300 ligand 2 | CBP/p300 ligand 2 is a ligand for target protein for PROTAC of dCBP-1. dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2484741-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138539. | |
| CBR-470-1 | CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP+-induced cytotoxicity through activation of the Keap1-Nrf2 cascade[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2416095-06-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134205A. | |
| CBR-470-1 | CBR-470-1, a non-covalent Nrf2 activator, is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). It protects SH-SY5Y neuronal cells from MPP+ induced cytotoxicity by activating the Keap1-Nrf2 cascade. Synonyms: 3-Thiophenamine, 4-[(4-chlorophenyl)sulfonyl]tetrahydro-N-(2-methylpropyl)-, 1,1-dioxide, (3R,4S)-rel-; (3S,4R)-4-[(4-Chlorophenyl)sulfonyl]-N-isobutyltetrahydro-3-thiophenamine 1,1-dioxide; (3S,4R)-4-[(4-chlorophenyl)sulfonyl]-3-[(2-methylpropyl)amino]thiolane-1,1-dione. Grade: ≥98%. CAS No. 2416095-06-0. Molecular formula: C14H20ClNO4S2. Mole weight: 365.90. | |
| CBR-470-2 | CBR-470-2, an analogue of glycine substitution, activates NRF2 signaling and can be used to study modulation glycolysis. Synonyms: N-{(3S,4R)-4-[(3,4-Dichlorophenyl)sulfonyl]-1,1-dioxidotetrahydro-3-thiophenyl}glycine; Glycine, N-[(3R,4S)-4-[(3,4-dichlorophenyl)sulfonyl]tetrahydro-1,1-dioxido-3-thienyl]-, rel-. Grade: ≥95%. CAS No. 2416095-00-4. Molecular formula: C12H13Cl2NO6S2. Mole weight: 402.27. | |
| CBR 5884 | CBR 5884 is a 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM), does not affect other NAD+-dependent dehydrogenases. Uses: 3-phosphoglycerate dehydrogenase (phgdh) inhibitor. Synonyms: CBR-5884; CBR 5884; CBR5884. Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate. Grade: ≥98%. CAS No. 681159-27-3. Molecular formula: C14H12N2O4S2. Mole weight: 336.39. | |
| CBR-5884 | CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 681159-27-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100012. | |
| CBS1117 | CBS1117 is an effective inhibitor of influenza A virus entry, which can inhibit influenza virus hemagglutinin. Synonyms: 2,6-Dichloro-N-[1-(Propan-2-Yl)Piperidin-4-Yl]Benzamide. Grade: 98%. CAS No. 959245-08-0. Molecular formula: C15H20Cl2N2O. Mole weight: 315.2. | |
| CBS9106 | CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. Synonyms: SL-801; SL801; SL 801; CBS-9106; CBS 9106; BMS-566419; BMS566419; BMS 566419; 1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-[(3,3-dimethylbutoxy)methyl]-4-methyl-. Grade: 98%. CAS No. 1076235-04-5. Molecular formula: C18H21ClF3N3O3. Mole weight: 419.83. | |
| CBT-161 | CBT-161 is an ADC that STI-A0602, the monoclonal antibody targeting c-Met, links tubulin inhibitors or DNA damaging agents via C-lock. Preclinical study showed that CBT-161 significantly inhibited tumor growth. Uses: Antitumor drug. Synonyms: Anti-cMET ADC. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm | c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm is an effective and selective short-acting peptide V2 receptor (V2R) agonist. Synonyms: D-Argininamide, 4-chloro-N-(4-mercapto-1-oxobutyl)-L-phenylalanyl-3-(2-thienyl)-L-alanyl-L-valyl-L-asparaginyl-L-cysteinyl-L-prolyl-N,N-diethyl-, cyclic (1→5)-thioether. CAS No. 1647119-71-8. Molecular formula: C47H69ClN12O9S2. Mole weight: 1045.71. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 | c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 is an effective and selective short-acting peptide V2 receptor (V2R) agonist. Synonyms: Velmupressin; L-Prolinamide, 4-chloro-N-(4-mercapto-1-oxobutyl)-L-phenylalanyl-3-(2-thienyl)-L-alanyl-L-valyl-L-asparaginyl-L-cysteinyl-N-(4-((aminoiminomethyl)amino)butyl)-, cyclic (1->5)-thioether. Grade: ≥98%. CAS No. 1647119-61-6. Molecular formula: C42H60ClN11O8S2. Mole weight: 946.58. | |
| c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt2 acetate | It is a potent, selective and short-acting peptide V2 receptor (V2R) agonist. Synonyms: 1-{[(3R,6S,9S,12S,15S)-6-(2-Amino-2-oxoethyl)-15-(4-chlorobenzyl)-9-isopropyl-5,8,11,14,17-pentaoxo-12-(2-thienylmethyl)-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl]carbonyl}-N-(4-carbamimidamidobutyl)-L-prolinamide acetate (1:1). Grade: ≥98%. CAS No. 1647120-04-4. Molecular formula: C44H64ClN11O10S2. Mole weight: 1006.63. | |
| Cbz-1-amino-1-cyclooctanecarboxylic acid | Cbz-1-amino-1-cyclooctanecarboxylic acid. Alternative Names: CBZ-1-AMINO-1-CYCLOOCTANECARBOXYLIC ACID. CAS No. 175407-63-3. Purity: 96%. Product ID: ACM175407633. Molecular formula: C17H23NO4. Mole weight: 305.37. IUPAC Name: 1-(phenylmethoxycarbonylamino)cyclooctane-1-carboxylate. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Cbz-1-amino-1-cyclopentanecarboxylic acid | Cbz-1-amino-1-cyclopentanecarboxylic acid. CAS No. 17191-44-5. Purity: 98%. Product ID: ACM17191445. Molecular formula: C14H17NO4. Mole weight: 263.29. Alfa Chemistry - ISO 9001:32057 Certified. | |
| CBZ-8-amino-3,6-dioxaoctanoic acid | CBZ-8-amino-3,6-dioxaoctanoic acid. CAS No. 16545-06-8. |  |
| CBZ-9-amino-4,7-dioxanonanoic acid | CBZ-9-amino-4,7-dioxanonanoic acid. CAS No. 462100-05-6. | |
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