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| Product | Description | |
|---|---|---|
| CCK-4 Acetate | Tetragastrin is a tetrapeptide. Synonyms: CCK-4; CCK4; CCK 4; Gastrin Tetrapeptide; Cholecystokinin Octapeptide (5-8); Cholecystokinin Tetrapeptide; Gastrin (14-17) (human). CAS No. 35144-91-3. Molecular formula: C29H36N6O6S. Mole weight: 596.70. |  |
| CCK-A receptor inhibitor 1 | CCK-A receptor inhibitor 1 is an inhibitor of cholecystokinin A (CCK-A) receptor with a binging IC50 of 340 nM. Synonyms: Pentanoic acid, 5-[(3-methoxypropyl)pentylamino]-4-[(2-naphthalenylsulfonyl)methyl]-5-oxo-; 5-[(3-Methoxypropyl)(pentyl)amino]-4-[(2-naphthylsulfonyl)methyl]-5-oxopentanoic acid. Grade: ≥95%. CAS No. 137004-80-9. Molecular formula: C25H35NO6S. Mole weight: 477.61. | |
| CCKBR agonist-1 | CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC50 of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC50 of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923120-30-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P11540. |  |
| CCK-B Receptor Antagonist 1 | CCK-B Receptor Antagonist 1 is a cholecystokinin B (CCK-B) receptor antagonist with the potential to reduce gastric acid secretion. Synonyms: Urea, N-[1-(3,3-dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]-; 1-[1-(3,3-Dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-3-[3-(methylamino)phenyl]urea. Grade: ≥99%. CAS No. 168161-71-5. Molecular formula: C28H30N6O3. Mole weight: 498.58. | |
| CCK-B Receptor Antagonist 2 | CCK-B Receptor Antagonist 2, a potent and orally active Gastrin/CCK-B antagonist (IC50 = 0.43 nM), also inhibits gastrin/CCK-A activity with an IC50 of 1.82 μM. Synonyms: (R)-1-(3-Aminophenyl)-3-(1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)urea; 1-(3-Amino-phenyl)-3-[(R)-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-5-pyridin-2-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-urea; 1-(3-Aminophenyl)-3-[(3R)-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-5-(2-pyridinyl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]urea. Grade: ≥98%. CAS No. 155412-88-7. Molecular formula: C27H28N6O3. Mole weight: 484.55. | |
| CCK Octapeptide (non-sulfated) | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK Octapeptide (non-sulfated) is the non-sulfated form of the C-terminal octapeptide of CCK. Synonyms: CCK-8 (desulfated); Cholecystokinin (CCK) (26-33); 2-desulfo-cholecystokinin-8 (swine). Grade: 98%. CAS No. 25679-24-7. Molecular formula: C49H62N10O13S2. Mole weight: 1063. | |
| CCK Octapeptide, non-sulfated acetate | Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. CCK Octapeptide (non-sulfated) is the non-sulfated form of the C-terminal octapeptide of CCK. Synonyms: CCK-8 (desulfated) acetate; Cholecystokinin (CCK) (26-33) acetate. Molecular formula: C51H66N10O15S2. Mole weight: 1123.26. | |
| CCL27 | CCL27 is a chemotactic factor that attracts skin-associated memory T-lymphocytes. It may play a role in mediating homing of lymphocytes to cutaneous sites. Synonyms: C-C Motif Chemokine Ligand 27. | |
| Cc-LTP1 | Cc-LTP1 is produced by Coffea canephora. It has active antifungal activity against Candida albicans. | |
| CCM Alloy Powder | CCM is a non-magnetic, cobalt-chromium molybdenum alloy exhibiting high strength, corrosion resistance, wear resistance, and excellent biocompatibility. CCM alloy powder is produced by vacuum induction melting (VIM) followed by nitrogen gas atomization. It has excellent weldability in laser additive manufacturing processes and can be processed with either nitrogen or argon shielding gas. |  |
| CCMI | CCMI. Group: Biochemicals. Grades: Purified. CAS No. 917837-54-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| CCMI | CCMI is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (nAChR). It was shown to induce positive modulation of acetylcholine (ACh)-induced EC5 currents (EC50 = 0.7 μM). CCMI enhances cognition in rodent models. Synonyms: AVL-3288; AVL 3288; AVL3288; XY-4083; XY 4083; XY4083; [N-(4-Chlorophenyl)]-α-[(4-chlorophenyl)-aminomethylene]-3-methyl-5-isoxazoleacetamide; (Z)-3-(4-chloroanilino)-N-(4-chlorophenyl)-2-(3-methyl-1,2-oxazol-5-yl)prop-2-enamide. CAS No. 917837-54-8. Molecular formula: C19H15Cl2N3O2. Mole weight: 388.25. | |
| cCMP | cCMP, an intriguing cyclic cytidine monophosphate compound extensively utilized in the realm of biomedical research, has emerged as an invaluable protagonist. Affiliated with the intricacies of various signaling pathways, it conveniently serves as a second messenger, facilitating a comprehensive comprehension of cCMP's involvement in pivotal cellular functions. In the realm of immunology, its versatile nature enables it to diligently modulate the immune response, thus exhibiting promising potential in the battle against inflammatory diseases and cancerous afflictions. Synonyms: Cytidine- 3', 5'- cyclic monophosphate, sodium salt. Grade: ≥ 98% by HPLC. CAS No. 54925-33-6. Molecular formula: C9H11N3O7P ยท Na. Mole weight: 327.2. | |
| cCMP-AM | cCMP-AM is a membrane-permeant and metabolically activatable prodrug of cCMP, the potential further second messenger. cCMP is released after permeation and metabolism of cCMP-AM by esterases, which is trapped inside the cell and metabolized to result in a pulse-type signal. Synonyms: Cytidine- 3', 5'- cyclic monophosphate, acetoxymethyl ester. Grade: ≥ 95% by HPLC. Molecular formula: C12H16N3O9P. Mole weight: 377.2. | |
| CCMQ | CCMQ is an inhibitor of homoquinolinic acid binding to non-NMDA sensitive sites. It is combined with [3H]-homoquinolinic acid to characterize NR2B-containing NMDA receptors. Synonyms: 2-Carboxy-3-carboxymethylquinoline. CAS No. 132623-44-0. Molecular formula: C12H9NO4. Mole weight: 231.21. | |
| CCMV Gag-(7-25) | It is a cell penetrating peptide. Synonyms: H-Lys-Leu-Thr-Arg-Ala-Gln-Arg-Arg-Ala-Ala-Ala-Arg-Lys-Asn-Lys-Arg-Asn-Thr-Arg-OH; L-lysyl-L-leucyl-L-threonyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-alanyl-L-alanyl-L-arginyl-L-lysyl-L-asparagyl-L-lysyl-L-arginyl-L-asparagyl-L-threonyl-L-arginine. Grade: ≥95%. Molecular formula: C93H175N43O25. Mole weight: 2295.70. | |
| CCPA | CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA inhibits adenylate cyclase with an IC50 of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Chloro-N6-cyclopentyladenosine. CAS No. 37739-05-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103185. | |
| CCP peptide TFA | CCP peptide TFA is a synthetic cyclic citrullinated peptide that can be used as the substrate for detecting anti-CCP antibodies serologically. Synonyms: His-Gln-Cys-His-Gln-Glu-Ser-Thr-{Cit}-Gly-Arg-Ser-Arg-Gly-Arg-Cys-Gly-Arg-Ser-Gly-Ser (Disulfide bridge: Cys3-Cys16). Grade: 95%. Molecular formula: C89H146N41F3O34S2. Mole weight: 2455.49. | |
| CC-preferring endodeoxyribonuclease | Prefers CC sites in double-stranded circular and linear DNA. Greater affinity for double-stranded than single-stranded DNA. Produces nicks, generating double-stranded fragments with 5'- and/or 3'-protruding single-stranded tails. Requires magnesium ions for activity. The endonuclease from Chlorella-like green algae infected with NYs-1 virus 4 may be the same enzyme. Group: Enzymes. Synonyms: Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease. Enzyme Commission Number: EC 3.1.21.6. CAS No. 37211-67-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3576; CC-preferring endodeoxyribonuclease; EC 3.1.21.6; 37211-67-9; Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease. Cat No: EXWM-3576. |  |
| CCR1 antagonist | CCR1 antagonist is a chemokine CCR1 antagonist. It is used for the treatment of chronic obstructive pulmonary disease. Uses: Ccr1 antagonist is used for the treatment of chronic obstructive pulmonary disease. Synonyms: AZD-4818; AZD 4818; AZD4818. (S)-2-(2-chloro-5-(3-(5-chloro-3H-spiro[benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropoxy)-4-(methylcarbamoyl)phenoxy)-; 2-[2-Chloro-5-[(2S)-3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)-2-hydroxypropoxy]-4-(methylcarbamoyl)phenoxy]-2-methylpropanoic acid. Grade: >98 %. CAS No. 1003566-93-5. Molecular formula: C27H32Cl2N2O7. Mole weight: 567.46. | |
| CCR1 antagonist 6 | CCR1 antagonist 6 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 3 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[5-(methylsulfonyl)-3-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[5-(methylsulfonyl)-3-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. CAS No. 2436773-01-0. Molecular formula: C21H23ClN4O3S. Mole weight: 446.95. | |
| CCR1 antagonist 7 | CCR1 antagonist 7 is a chemokine receptor 1 (CCR1) antagonist with an IC50 of 4 nM. Synonyms: 1H-Pyrazole-4-carboxamide, 1-(4-chlorophenyl)-5-methyl-N-[(1S)-1-[2-[(methylamino)sulfonyl]-4-pyridinyl]butyl]-; 1-(4-Chlorophenyl)-5-methyl-N-{(1S)-1-[2-(methylsulfamoyl)-4-pyridinyl]butyl}-1H-pyrazole-4-carboxamide. Grade: 98%. CAS No. 2446154-74-9. Molecular formula: C21H24ClN5O3S. Mole weight: 461.96. | |
| CCR1 antagonist 9 | CCR1 antagonist 9 is a potent and selective antagonist of CCR1 with an IC50? of? 6.8 nM in calcium flux assay. Synonyms: 1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid (2-methanesulfonyl-pyridin-4-ylmethyl)-amide; CCR1 inhibitor 19e; 1H-Pyrazolo[3,4-c]pyridine-4-carboxamide, 1-(4-fluorophenyl)-N-[[2-(methylsulfonyl)-4-pyridinyl]methyl]-; 1-(4-Fluorophenyl)-N-{[2-(methylsulfonyl)-4-pyridinyl]methyl}-1H-pyrazolo[3,4-c]pyridine-4-carboxamide. Grade: ≥95%. CAS No. 1220026-26-5. Molecular formula: C20H16FN5O3S. Mole weight: 425.44. | |
| CCR2 antagonist 1 | CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM. Synonyms: [(1S,3R)-3-{[(1R)-5-Bromo-2,3-dihydro-1H-inden-1-yl]amino}-1-isopropylcyclopentyl][7-(trifluoromethyl)-3,4-dihydro-2(1H)-isoquinolinyl]methanone; Methanone, [(1S,3R)-3-[[(1R)-5-bromo-2,3-dihydro-1H-inden-1-yl]amino]-1-(1-methylethyl)cyclopentyl][3,4-dihydro-7-(trifluoromethyl)-2(1H)-isoquinolinyl]-; (1R)-5-bromo-N-[(1R,3S)-3-(propan-2-yl)-3-[7-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]cyclopentyl]-2,3-dihydro-1H-inden-1-amine. Grade: ≥98%. CAS No. 1683534-96-4. Molecular formula: C28H32BrF3N2O. Mole weight: 549.47. | |
| CCR2 antagonist 3 | CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist. Synonyms: AZD2927; AZD-2927; (S)-4-Fluoro-N-(1-(3-hydroxyazetidin-1-yl)-3-methylbutan-2-yl)-N,3-dimethylbenzamide; 4-Fluoro-N-[(2S)-1-(3-hydroxy-1-azetidinyl)-3-methyl-2-butanyl]-N,3-dimethylbenzamide. Grade: ≥98%. CAS No. 1380100-86-6. Molecular formula: C17H25FN2O2. Mole weight: 308.39. | |
| CCR2-RA | CCR2-RA is a novel C-C chemokine receptor type 2 (CCR2) antagonist. Synonyms: 2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-. Grade: 95%. CAS No. 512177-31-0. Molecular formula: C18H19ClFNO3. Mole weight: 351.8. | |
| CCR2-RA-[R] | CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 512177-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50081. | |
| CCR3 antagonist 1 | A potent antagonist of CCR3 (IC50= 1.8 nM). Synonyms: CCR3 antagonist 1; CCR 3 antagonist 1; CCR-3 antagonist 1; 4-Thiazoleacetic acid, 2-[[2-[[[(2S)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]-2-oxoethyl]thio]-. CAS No. 879399-82-3. Molecular formula: C19H21Cl2N3O4S2. Mole weight: 490.42. | |
| CCR4-351 hydrochloride | CCR4-351 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2174938-71-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-131349A. | |
| CCR4 Antagonist | A potent CCR4 antagonist. Synonyms: C 021 dihydrochloride; C021 dihydrochloride; C-021 dihydrochloride; 2-(1,4'-Bipiperidine-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine; C-021; CCR4 Antagonist; CHEMBL508207; 2-(1,4'-Bipiperidin)-1'-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolina. CAS No. 864289-85-0. Molecular formula: C27H41N5O2. Mole weight: 467.6. | |
| CCR4 antagonist 2 | CCR4 antagonist 2 is a potent and orally bioavailable small molecule CCR4 antagonist, with IC50s of 40 and 70 nM for Ca2+ flux and (chemotaxis) CTX, respectively. It inhibits Treg trafficking into the tumor microenvironment without suppressing the number of Treg in healthy tissue. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl]-; 1-[(1R)-1-(2,4-Dichlorophenyl)ethyl]-6-{(4S,5R)-4-[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]-5-methyl-1-cyclohexen-1-yl}-1H-pyrazolo[3,4-b]pyrazine-3-carbonitrile. Grade: ≥97%. CAS No. 2206788-99-8. Molecular formula: C26H28Cl2N6O. Mole weight: 511.45. | |
| CCR4 antagonist 3 | CCR4 antagonist 3, a potent, selective and orally active CCR4 antagonist, has a novel piperidinyl-azetidine motif with IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. It has antitumor activity. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)-3-piperidinyl]-1-azetidinyl]-. CAS No. 2174938-70-4. Molecular formula: C24H27Cl2N7O. Mole weight: 500.42. | |
| CCR4 antagonist 3 | CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1957-1-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147385. | |
| CCR4 antagonist 3 hydrochloride | CCR4 antagonist 3 hydrochloride, a potent, selective and orally active CCR4 antagonist, has a novel piperidinyl-azetidine motif with IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. It has antitumor activity. Synonyms: 1H-Pyrazolo[3,4-b]pyrazine-3-carbonitrile, 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[3-[(3R)-1-(2-hydroxyethyl)-3-piperidinyl]-1-azetidinyl]-, hydrochloride (1:x). Grade: ≥98%. CAS No. 2174938-71-5. Molecular formula: C24H27Cl2N7O.xHCl. Mole weight: 500.42 (free base). | |
| CCR4 antagonist 4 | CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 668980-17-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157453. | |
| CCR5 antagonist 1 | CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2 that can inhibit HIV replication. Synonyms: AC-31371; HY-100261. Grade: >98%. CAS No. 716354-86-8. Molecular formula: C39H46ClF2N5O3S. Mole weight: 738.3. | |
| CCR6 antagonist 1 | CCR6 antagonist 1 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 588674-64-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151435. | |
| CCR6 inhibitor 1 | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2437547-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112701. | |
| CCR6 inhibitor 1 | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50 >30000 nM), and CCR7 (IC50 = 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation and is used in the study of autoimmune diseases and cancer. Synonyms: 2-Pyridinecarboxamide, 4-[4-[[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]amino]cyclohexyl]sulfonyl]phenyl]-; 4-{4-[(trans-4-{[5-(Trifluoromethyl)-2-pyridinyl]amino}cyclohexyl)sulfonyl]phenyl}-2-pyridinecarboxamide. Grade: ≥98%. CAS No. 2437547-04-9. Molecular formula: C24H23F3N4O3S. Mole weight: 504.52. | |
| CCR7 Ligand 1 | CCR7 Ligand 1 is an allosteric Ligand and human CC chemokine receptor 7 (CCR7) antagonist with a Kd of 3 nM. It is a thiadiazole-dioxide ligand that suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM. Synonyms: CCR7-Cmp2105; Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N,6-trimethyl-; 3-[(4-{[(1R)-2,2-Dimethyl-1-(5-methyl-2-furyl)propyl]amino}-1,1-dioxido-1,2,5-thiadiazol-3-yl)amino]-2-hydroxy-N,N,6-trimethylbenzamide. Grade: ≥98%. CAS No. 681514-83-0. Molecular formula: C22H29N5O5S. Mole weight: 475.56. | |
| CCR7 Ligand 1 | CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCR7-Cmp2105. CAS No. 681514-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-133073. | |
| CCT007093 | CCT007093 is a potent PPM1D inhibitor or WIP1 inhibitor that selectively reduces viability of human tumour cell lines. Synonyms: CCT007093; CCT-007093; CCT 007093. Grade: 0.98. CAS No. 176957-55-4. Molecular formula: C15H12OS2. Mole weight: 272.38. | |
| CCT018159 | CCT018159 is a novel inhibitor of heat shock protein (Hsp) 90 with potential anticancer activity. CCT018159 inhibited human Hsp90beta with comparable potency to 17-AAG and with similar ATP-competitive kinetics. The mean cellular GI(50) value of CCT018159 across a panel of human cancer cell lines, including melanoma, was 5.3 mumol/L. CCT018159 caused cell cytostasis associated with a G(1) arrest and induced apoptosis. CCT018159 also inhibited key endothelial and tumor cell functions implicated in invasion and angiogenesis. Synonyms: CCT-018159; CCT 018159. Grade: >98%. CAS No. 171009-07-7. Molecular formula: C20H20N2O4. Mole weight: 352.39. | |
| CCT018159 | CCT018159 is an ATP-competitive HSP90β inhibitor, with an IC50 of 3.2 μM against human HSP90β ATPase and 6.6 μM against yeast HSP90β ATPase. CCT018159 induces cell cycle arrest and apoptosis in tumor cells, and inhibits invasion and angiogenesis. CCT018159 is applicable to cancer-related research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 171009-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-110042. | |
| CCT 018159 | CCT 018159. Group: Biochemicals. Grades: Purified. CAS No. 171009-07-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CCT020312 | CCT020312 is a potent and selective EIF2AK3 activator. Synonyms: HY-119240. CAS No. 324759-76-4. Molecular formula: C31H30Br2N4O2. Mole weight: 650.40. | |
| CCT020312 | CCT020312 is a selective EIF2AK3/PERK activator. CCT020312 elicits EIF2A phosphorylation in cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 324759-76-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119240. | |
| CCT 031374 hydrobromide | CCT 031374 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 1219184-91-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CCT 031374 hydrobromide | CCT 031374 hydrobromide is an inhibitor of TCF-dependent transcription. It was shown to block BIO-induced β-catenin stabilization, and reduce nuclear and cytosolic β-catenin levels in mouse L-cells. Synonyms: SR 01000418274; CCT 031374 hydrobromide; SR01000418274; CCT031374 hydrobromide; SR-01000418274; CCT-031374 hydrobromide; 1-[1,1'-Biphenyl]-4-yl-2-(2,3-dihydro-9H-imidazo[1,2-a]benzimidazol-9-yl)ethanone hydrobromide. Grade: ≥98% by HPLC. CAS No. 1219184-91-4. Molecular formula: C23H19N3O.HBr. Mole weight: 434.33. | |
| CCT036477 | CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305372-78-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-119966. | |
| CCT128930 | CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC50=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM). Antitumor activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 885499-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13260. | |
| CCT128930 | CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. Synonyms: CCT128930; CCT-128930; CCT 128930. CAS No. 885499-61-6. Molecular formula: C18H20ClN5. Mole weight: 341.8379. | |
| CCT128930 hydrochloride | CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50 = 6 nM). CCT128930 hydrochloride also induces cell cycle arrest, DNA damage, and autophagy. Synonyms: 4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine hydrochloride. Grade: 98%. CAS No. 2453324-32-6. Molecular formula: C18H21Cl2N5. Mole weight: 378.30. | |
| CCT129202 | CCT129202 is an inhibitor of Aurora kinase activity and displays a favorable antineoplastic effect in preclinical studies. CCT129202 significantly reversed ABCB1- and ABCG2-mediated MDR in vitro, in vivo and ex vivo by inhibiting the function of their transporters and enhanced the eradication of cancer stem-like cells by chemotherapeutic agents. CCT129202 may be a candidate as MDR reversal agent for antineoplastic combination therapy and merits further clinical investigation. Synonyms: CCT129202; CCT-129202; CCT 129202. CAS No. 942947-93-5. Molecular formula: C23H25ClN8OS. Mole weight: 497.02. | |
| CCT129957 | CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 883098-58-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111208. | |
| CCT 137690 | CCT 137690 is a potent and orally available aurora kinase inhibitor with IC50s of 15, 25, and 19 nM for aurora A, B and C, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1095382-05-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10804. | |
| CCT-137690 | CCT137690, an aurora kinase inhibitor CCT137690, is a highly selective, orally bioavailable imidazo[4,5-b]pyridine derivative that inhibits Aurora A and B kinases with low nanomolar IC50 values in both biochemical and cellular assays and exhibits anti-proliferative activity against a wide range of human solid tumour cell lines. CCT137690 efficiently inhibits histone H3 and TACC3 phosphorylation (Aurora B and Aurora A substrates, respectively) in HCT116 and HeLa cells. Continuous exposure of tumour cells to the inhibitor causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis. This is accompanied by p53/p21/BAX induction, thymidine kinase 1 (TK1) downregulation and PARP cleavage. Furthermore, CCT137690 treatment of MYCN-amplified neuroblastoma cell lines inhibits cell proliferation and decreases MYCN protein expression. Importantly, in a transgenic mouse model of neuroblastoma (TH-MYCN) that overexpresses MYCN protein and is predisposed to spontaneous neuroblastoma formation, this compound significantly inhibits tumour growth. The potent preclinical activity of CCT137690 suggests that this inhibitor may benefit patients with MYCN amplified neuroblastoma. Synonyms: CCT-137690. CCT 137690. CCT137690. CAS No. 1095382-05-0. Molecular formula: C26H31BrN8O. Mole weight: 551.48. | |
| CCT196969 | This active molecular is a novel , paradox-breaking pan-RAF inhibitor with anti-SRC activity and it blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK -ERK. CCT196969 also prevented growth of xenografts derived from patient tumours with resistance to BRAF and MEK inhibitors. Uses: Effective in drug-resistant braf mutant melanoma. Synonyms: CCT196969; CCT-196969; CCT 196969. N-[4-[(3,4-Dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]urea. Grade: 98%. CAS No. 1163719-56-9. Molecular formula: C27H24FN7O3. Mole weight: 513.52. | |
| CCT241161 | This active molecular is a novel , paradox-breaking pan-RAF inhibitor with anti-SRC activity and it blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK -ERK. CCT 241161 also prevented growth of xenografts derived from patient tumours with resistance to BRAF and MEK inhibitors. Uses: Effective in drug-resistant braf mutant melanoma. Synonyms: CCT241161; CCT-241161; CCT 241161. 1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-(methylthio)-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea. Grade: 98%. CAS No. 1163719-91-2. Molecular formula: C28H27N7O3S. Mole weight: 541.62. | |
| CCT 241533 dihydrochloride | CCT 241533 dihydrochloride is a potent Chk2 inhibitor (IC50 = 3 nM) displaying >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. CCT 241533 inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells, and blocks ionizing radiation-induced apoptosis of mouse thymocytes. Synonyms: CCT 241533 dihydrochloride; CCT241533 dihydrochloride; CCT-241533 dihydrochloride; (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride. Grade: ≥98% by HPLC. CAS No. 1962925-28-5. Molecular formula: C23H27FN4O4.2HCl. Mole weight: 515.41. | |
| CCT241533 hydrochloride | CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1431697-96-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14715B. | |
| CCT241736 | CCT241736 is a potent and orally active and dual FLT3-Aurora inhibitor, which has IC50 values against FLT3, Aurora A and Aurora B of 0.035, 0.015 and 0.1 μM respectively. It also inhibits viability of the human FLT3-ITD positive AML cell lines MOLM-13 with 0.1 μM in cellular assay. Synonyms: CCT-241736; CCT 241736. Grade: ≥98%. CAS No. 1402709-93-6. Molecular formula: C22H23Cl2N7. Mole weight: 456.37. | |
| CCT244747 | CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. Synonyms: CCT-244747; CCT 244747; 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile; 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile; (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile. Grade: ≥98%. CAS No. 1404095-34-6. Molecular formula: C20H24N8O2. Mole weight: 408.46. | |
| CCT245737 | CCT245737 is an orally bioactive CHK1 inhibitor (IC50 of 1.4 nM), displaying >1,000-fold selectivity against CHK2 and CDK1. It potently inhibits cellular CHK1 activity (IC50 30-220nM) and enhances gemcitabine and SN38 cytotoxicity in multiple human tumor cell lines and human tumor xenograft models. It causes inhibition of tumor growth in an Eμ-Myc mouse model of human B-cell lymphocytic leukemia. Synonyms: CCT-245737; CCT 245737; CCT245737; 5-[(4-{[(2R)-morpholin-2-ylmethyl]amino}-5-(trifluoromethyl)pyridin-2-yl)amino]pyrazine-2-carbonitrile. CAS No. 1489389-18-5. Molecular formula: C16H16F3N7O. Mole weight: 379.347. | |
| CCT245737 | CCT245737 (SRA737) is an orally active and seletive Chk1 inhibitor, with an IC50 of 1.3 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SRA737. CAS No. 1489389-18-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18958. | |
| CCT245737(S) | CCT245737, a nitrogen heterocycle compound, has been found to be a CHK1 inhibitor that could probable be effective in antineoplastic studies. It is still under Phase I trail for Solid tumours. IC50: 30-220 nM. Synonyms: CCT245737; CCT 245737; CCT-245737; GTPL9187; GTPL 9187; GTPL-9187; 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)pyridin-2-yl]amino]pyrazine-2-carbonitrile. Grade: 98%. CAS No. 1489389-23-2. Molecular formula: C16H16F3N7O. Mole weight: 379.14. | |
| CCT-251236 | CCT-251236 is an orally active Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen, which exhibited efficacy in a human ovarian carcinoma xenograft model. Uses: The potential treatment of ovarian carcinoma. Synonyms: CCT251236; CCT 251236; N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(pyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide; N-[5-(2,3-dihydro-1,4-benzodioxine-6-amido)-2-methylphenyl]-2-[2-(pyrrolidin-1-yl)ethoxy]quinoline-6-carboxamide; 6-Quinolinecarboxamide, N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-. Grade: ≥95%. CAS No. 1693731-40-6. Molecular formula: C32H32N4O5. Mole weight: 552.62. | |
| CCT251545 | CCT251545, a small molecule inhibitor of WNT signaling with oral activity, can be used as a selective chemical probe that exhibits >100-fold selectivity for the human Mediator complex-associated protein kinases CDK8 and CDK19 over 291 other kinases. IC50: Synonyms: 8-[3-chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneCCT251545; CCT 251545; CCT-251545; CHEMBL34082138-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one8-{3-Chloro-5-[4-(1-Methyl-1h-Pyrazol-4-Yl)ph. CAS No. 1661839-45-7. Molecular formula: C23H24ClN5O. Mole weight: 421.92. | |
| CCT251545 | CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells[1]. CCT251545 is a selective chemical probe for exploring the role of CDK8 and CDK19 in human disease[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1661839-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12681. | |
| CCT-251921 | CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor with an IC50 of 2.3 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1607837-31-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19984. | |
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