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| Product | Description | |
|---|---|---|
| CD-2 | CD-2 (Part#: 1088) |  |
| CD20 (188-196) | CD20 (188-196) is a truncated fragment of a membrane phosphoprotein, CD20, which is expressed on the surface of B cells. CD20 receptor is an important target for immunotherapy against B cell lymphoma. Alternative Names: B-lymphocyte antigen CD20 (188-196). Grades: >95%. Molecular formula: C46H77N9O12. Mole weight: 948.16. |  |
| CD206/MRC1 Antibody [K13P18] | CD206/MRC1 Antibody [K13P18]. Group: Antibodies. Alternative Names: Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor (hMR), Macrophage mannose receptor 1-like protein 1, CD206, MRC1, CLEC13D, CLEC13DL, MRC1L1. CAS No. Pack Sizes: 20uL. Product ID: F4083. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| CD 2314 | CD 2314. Group: Biochemicals. Grades: Purified. CAS No. 170355-37-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| CD2665 | CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively[1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 170355-78-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107437. |  |
| CD 2665 | CD 2665. Group: Biochemicals. Grades: Purified. CAS No. 170355-78-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Cd2+-exporting ATPase | A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants. Group: Enzymes. Enzyme Commission Number: EC 3.6.3.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4667; Cd2+-exporting ATPase; EC 3.6.3.3. Cat No: EXWM-4667. |  |
| CD-3 | CD-3 (Part#: 1090) | |
| CD31 (PECAM-1) Antibody [M18G16] | CD31,CD31 (PECAM-1),CD31 / PECAM-1,PECAM-1. Group: Antibodies. Alternative Names: CD31,PECAM-1. Pack Sizes: 20uL. Product ID: F0131. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| CD 3254 | CD 3254. Group: Biochemicals. Grades: Purified. CAS No. 196961-43-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CD33 splicing modulator 1 | CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 has the potential for the research of neurodegenerative disease including Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2762547-05-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144399. | |
| CD34+ Cells Targeted SM102 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared from SM102 as the ionizable lipid and modified with CD34 antibody. It's specifically designed for targeted delivery of EGFP mRNA to CD34 positive cells. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. |  |
| CD38 inhibitor 1 | CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1700637-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-123999. | |
| CD38 inhibitor 1 (compound 78c) | CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553) is a potent inhibitor of CD38 with IC50 of 7.3 nM and 1.9 nM for human CD38 and mouse CD38, respetively. Group: Inhibitors. Alternative Names: CD38-IN-78c, MDK-7553. CAS No. 1700637-55-3. Pack Sizes: 5mg. Product ID: S8960. Formula: C22H27N3O3S. Smiles: CN1C2=C(C=C(C=C2)C3=CN=CS3)C(=CC1=O)NC4CCC(CC4)OCCOC. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| CD39-IN-1 | CD39-IN-1 is a selective CD39 inhibitor with an IC50 value of 68.7 nM. CD39-IN-1 exerts antiproliferative effects on tumor cells and shows low toxicity to normal cell lines. CD39-IN-1 inhibits CD39-mediated eATP hydrolysis in the ATP-adenosine pathway. CD39-IN-1 is applicable for tumor-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3097380-98-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-174341. | |
| CD-4 | CD-4 (Part#: 1095) | |
| CD437 | CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AHPN. CAS No. 125316-60-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100532. | |
| CD 437 | CD 437. Group: Biochemicals. Grades: Purified. CAS No. 125316-60-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CD532 | CD532 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 also can directly interact with AURKA and induces a global conformational shift. CD532 can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639009-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-112273. | |
| CD59 glycoprotein precursor (106-114) | CD59 glycoprotein precursor (106-114) is a peptide derived from CD59 glycoprotein precursor which is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 glycoprotein is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Alternative Names: HRF-20 (106-114); Membrane attack complex inhibition factor (106-114). | |
| CD63 Antibody [N10M7] | CD63 Antibody [N10M7]. Group: Antibodies. CAS No. Pack Sizes: 20uL. Product ID: F0983. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| CD68 Antibody [M20C19] | CD68,CD68/SR-D1. Group: Antibodies. Alternative Names: CD68, Macrosialin, Cd68. CAS No. Pack Sizes: 20uL. Product ID: F3794. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| CD9 Antibody [J21F10] | CD9 Antibody [J21F10]. Group: Antibodies. Pack Sizes: 20ul. Product ID: F1178. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. | United States; Europe |
| CDAP | CDAP is an organic cyanylating reagent that can be used for preparation of solid phase affinity reagents, modification of protein thiols and nucleotide delivery. CDAP also activates polysaccharides with a variety of chemical properties. CDAP can be used to prepare conjugate vaccines and other immune reagents[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59016-56-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W012184. | |
| Cdc25A (80-93) (human) | Cdc25A abundance fluctuates periodically during the cell division cycle and is mainly regulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, which later promote complex / cyclosome and Skp1/Cul1/F-box proteins. Due to the presence of the destruction motif (KEN-box) in Cdc25A, ubiquitination and degradation occur at the mitotic outlet and G1, while phosphorylation events modulate the stability of Cdc25A protein in the S phase, both in undisturbed cells and in cells exposed to DNA damage agents or DNA replication inhibitors. Alternative Names: H-Thr-Asp-Ser-Gly-Phe-Cys-Leu-Asp-Ser-Pro-Gly-Pro-Leu-Asp-OH. Grades: ≥95%. CAS No. 851538-67-5. Molecular formula: C60H90N14O24S. Mole weight: 1423.52. | |
| CDC25B-IN-1 | CDC25B-IN-1. CAS No. 2374831-10-2. | |
| Cdc7-IN-1 | Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1402055-25-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101523. | |
| CDD-1653 | CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034216-44-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164145. | |
| CDD-2789 | CDD-2789 is a potent and selective ALK2 inhibitor with an IC50 0.54 μM and a Kd of 2.1 nM, respectively. CDD-2789 exhibits >120-fold selectivity over ALK3/5/6. CDD-2789 reduces activin A- and BMP2-induced SMAD1/5 phosphorylation in fibroblasts. CDD-2789 can be used for ALK2-related cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052084-77-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173149. | |
| CDD-2807 | CDD-2807 is an inhibitor for serine/threonine kinase 33 (STK33) with IC50 of 9.2 nM. CDD-2807 exhibits no significant toxicity in mice and can cross the blood-testis barrier without accumulating in the brain. CDD-2807 induces a reversible contraceptive effect and has potential for the development of the male contraceptive[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3086536-23-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162565. | |
| CDDO-biotin | CDDO-biotin is an IKKβ inhibitor with cancer cell inhibitory activity. CDDO-biotin directly interacts with and oxidizes Cys-179 in the activation loop of IKKβ, forming an adduct with wild-type IKKβ. CDDO-biotin can be used in the research of myeloid leukemia, osteosarcoma, multiple myeloma, lung cancer, breast cancer and pancreatic cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3110422-01-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-186167. | |
| CDDO-dhTFEA | CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RTA dh404. CAS No. 1191265-33-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112671. | |
| CDDO-EA | CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CDDO ethyl amide; TP319; RTA 405. CAS No. 932730-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12213. | |
| CDDO-EA | CDDO-EA is an activator of Nrf2/ARE. It has neuroprotective effect. Alternative Names: CDDO ethyl amide; RTA405; TP319; RTA 405; TP 319; RTA-405; TP-319. Grades: >98%. CAS No. 932730-51-3. Molecular formula: C33H46N2O3. Mole weight: 518.73. | |
| CDDO Im | CDDO Im. Group: Biochemicals. Grades: Purified. CAS No. 443104-02-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CDDO-Im | CDDO-Im (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RTA-403; TP-235; CDDO-Imidazolide. CAS No. 443104-02-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15725. | |
| CDDO Imidazolide | CDDO Imidozolide is a synthetic triterpenoid as a Nrf2 signaling activator with highly active in suppressing cellular proliferation of human leukemia and breast cancer cell. Uses: Nrf2 signaling activator. Alternative Names: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; (4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile. Grades: ≥98 %. CAS No. 443104-02-7. Molecular formula: C34H43N3O3. Mole weight: 541.72. | |
| CDDO Imidazolide | CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers. Group: Biochemicals. Alternative Names: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid imidazolide; CDDO-Im; RTA 403; TP 235. Grades: Highly Purified. CAS No. 443104-02-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| C-Demethyl clethodim | C-Demethyl clethodim. Group: Biochemicals. Alternative Names: (E) -2-[1-[[ (3-Chloro-2-propenyl) oxy]imino]ethyl]-5-[2- (ethylthio) propyl]-1, 3-cyclohexanedione. Grades: Highly Purified. CAS No. 112301-96-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C16H24ClNO3S. US Biological Life Sciences. | Worldwide |
| C-Desmethyl Metoprolol | A new byproduct detected in Metoprolol tartrate. Group: Biochemicals. Alternative Names: 1-(Ethylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol; H 173/09. Grades: Highly Purified. CAS No. 109632-08-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CDH11-IN-1 | CDH11-IN-1 is a CDH11 inhibitor. CDH11-IN-1 regulates CDH11-mediated biological pathways. CDH11-IN-1 can be used for research on cancer and rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1239467-61-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-177575. | |
| c-di-2'-d-2''-O-Me-AMP | c-di-2'-d-2''-O-Me-AMP is an analogue of c-diAMP, the bacterial second messenger. Alternative Names: 2'- Deoxy- 2''- O- methyl- cyclic diadenosine monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C21H26N10O11P2 (free acid). Mole weight: 656.5 (free acid). | |
| c-di-2'-dAMP | c-di-2'-dAMP is an analogue of c-diAMP, the bacterial second messenger. Alternative Names: 2'- Deoxy- cyclic diadenosine monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H24N10O11P2 (free acid). Mole weight: 642.4 (free acid). | |
| c-di-2'-dGMP | c-di-2'-dGMP is an analogue of c-diGMP, the bacterial second messenger, which can be used to study ligand-receptor interactions. Alternative Names: 2'- Deoxy- cyclic diguanosine monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 132182-18-4. Molecular formula: C20H24N10O13P2 (free acid). Mole weight: 674.4 (free acid). | |
| c-di-AMP disodium | c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclic diadenylate disodium; Cyclic-di-AMP disodium. CAS No. 2734909-87-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12326A. | |
| c-di-AMP disodium | c-di-AMP disodium. CAS No. 2734909-87-4. Purity: HPLC > 97%. Product ID: ACM-ONT2734909874. Molecular formula: C20H22N10Na2O12P2. Mole weight: 702.38. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| c-Di-GMP | c-diGMP is a bacterial second messenger and a STING ligand. Alternative Names: 3'-Guanylic acid, guanylyl-(3'→5')-, cyclic nucleotide; 5GP-5GP; Cyclic di-3',5'-guanylate; Cyclic diguanylate; Cyclic diguanylate monophosphate; Cyclic-di-GMP; cGpGp; Cyclic diguanylic acid; cdiGMP; 3',5'-Cyclic diguanylic acid; c-(Gpgp); Bis(3',5')-cyclic diguanylic acid. Grades: ≥95%. CAS No. 61093-23-0. Molecular formula: C20H24N10O14P2. Mole weight: 690.41. | |
| C-DIM12 | C-DIM12 is a potent, orally active Nurr1 modulator. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DIM-C-pPhCl. CAS No. 178946-89-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19808. | |
| c-di-UMP | A STING agonist negative control. Alternative Names: Cyclic di-uridine monophosphate, c-di-UMP sodium salt. CAS No. 73120-97-5. Molecular formula: C18H20N4O16P2.2Na. Mole weight: 656.3. | |
| CDK12/13-IN-3 | CDK12/13-IN-3 (Compound 12b) is the orally active inhibitor for CDK that inhibits CDK12 and CDK13 with IC50 of 107.4 nM and 79.4 nM. CDK12/13-IN-3 inhibits the phosphorylation of Ser2 on the CTD of RNA polymerase II, induces DNA damage, and downregulates the gene expression of DNA damage response (DDR). CDK12/13-IN-3 exhibits antiproliferative activity against multiple cancer cells with IC50 of nanomolar levels. CDK12/13-IN-3 exhibits antitumor effect in mouse models, exhibits good pharmacokinetic properties with an oral bioavailability of 53.6%[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3029608-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173059. | |
| CDK12-IN-2 | CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2244987-03-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112626. | |
| CDK12-IN-3 | CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay. Uses: Scientific research. Category: Signaling pathways. CAS No. 2220184-50-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112261. | |
| CDK12-IN-8 | CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2928619-86-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-171786. | |
| Cdk1/2 Inhibitor III | Cdk1/2 Inhibitor III (compound 3n) is a highly potent and selective Cdk1/cyclin B and Cdk2/cyclin A inhibitor of with IC50s of 0.6 nM and 0.5 nM, respectively. Cdk1/2 Inhibitor III shows selectivity over VEGF-R2 (IC50 of 32 nM), GSK-3β (IC50 of 140 nM), and a other kinases. Cdk1/2 Inhibitor III inhibits in cell proliferation with IC50s of 20 nM, 35 nM and 92 nM for HCT-116, HeLa, and A375 cells, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 443798-55-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-112462. | |
| CDK2 | CDK2, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. Alternative Names: Cell division protein kinase 2; kinase Cdk2; p33 protein kinase; Anti-Gastric receptor I; Anti-H2R; His-His-Ala-Ser-Pro-Arg-Lys; L-histidyl-L-histidyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-lysine. Grades: ≥95%. CAS No. 255064-79-0. Molecular formula: C35H57N15O9. Mole weight: 831.92. | |
| CDK2 acetate | CDK2 acetate, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. Alternative Names: H-His-His-Ala-Ser-Pro-Arg-Lys-OH.CH3CO2H; L-histidyl-L-histidyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-lysine acetic acid. Grades: ≥95%. Molecular formula: C37H61N15O11. Mole weight: 891.99. | |
| CDK2 degrader 1 | CDK2 degrader 1 (Compound 3) is a selective CDK2 molecular glue degrader with a Dmax (CDK2) of > 80% and a Ki (CRBN) > 1 μM. CDK2 degrader 1 binds to cereblon to induce ubiquitination and subsequent proteasomal degradation of the CDK2. CDK2 degrader 1 is used in the research of a wide range of cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036604-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163814. | |
| CDK2 degrader 2 | CDK2 degrader 2 (Compound I-10) is a PROTAC degrader for CDK2 that degrades CDK2 in MKN1 cell with a DC50 <100 nM[1]. (Pink: ligand for target protein (HY-176124); Black: linker (HY-W687952); Blue: ligand for E3 ligase CRBN (HY-45512)). Uses: Scientific research. Category: Signaling pathways. CAS No. 3030271-16-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-163815. | |
| CDK2 degrader 3 | CDK2 degrader 3 is a selective CDK2 molecular glue-like degrader. CDK2 degrader 3 induces G1 cell cycle arrest in CCNE1-amplified cancer cells. CDK2 degrader 3 is applicable to breast cancer-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2862772-71-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-164827. | |
| CDK2 degrader 4 | CDK2 degrader 4 (compound 104) is a potent CDK2 degrader. CDK2 degrader 4 has the potential for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924122-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-169910. | |
| CDK2 degrader 5 | CDK2 degrader 5 is a CRBN-binding CDK2 molecular glue degrader. CDK2 degrader 5 induces ubiquitination and subsequent proteasomal degradation of CDK2. CDK2 degrader 5 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923574-11-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169912. | |
| CDK2 degrader 6 | CDK2 degrader 6 is an orally active and potent CDK2 molecular glue degrader with a DC50 of 46.5 nM. CDK2 degrader 6 binds to cereblon and CDK2 to induce ubiquitination and subsequent proteasomal degradation of CDK2. CDK2 degrader 6 modulates cell cycle in breast cancer cells. CDK2 degrader 6 reduces proliferation of breast cancer cells. CDK2 degrader 6 exhibits in vivo antitumor activity in gastric cancer mouse models. CDK2 degrader 6 can be used for the research of breast cancer, gastric cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036606-92-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-176444. | |
| CDK2 degrader 7 | CDK2 degrader 7 is an orally active CDK2 degrader, with DC50 values of 13 nM (MKN1cells) and 17 nM (TOV21G cells). CDK2 degrader 7 induces G1 phase arrest in MKN1 cells. CDK2 degrader 7 achieves tumor stasis in HCC1569 (CCNE1-amplified) xenograft models. CDK2 degrader 7 can be used for the study of CCNE1-amplified cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3030279-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-175842. | |
| CDK2-IN-30 | CDK2-IN-30 is a CDK2 inhibitor with an IC50 value ≤20 nM. CDK2-IN-30 modulates CDK2 activity to influence cell cycle regulation. CDK2-IN-30 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2640038-22-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164664. | |
| CDK2-IN-31 | CDK2-IN-31 is a CCNE1:CDK2 complex inhibitor with an IC50 of 0.13 μM. CDK2-IN-31 binds to a cryptic allosteric pocket at the CCNE1:CDK2 interface, inducing structural rearrangements of the CDK2 A-loop that disrupt the kinase's active conformation and interfere with substrate binding. CDK2-IN-31 inhibits phosphorylation of retinoblastoma protein 1 (RB1) in CCNE1-dependent ovarian cancer cells. CDK2-IN-31 impairs coenrichment of protein PRC1 with CCNE1-N112C:CDK2 complexes. CDK2-IN-31 can be used for the research of ovarian cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2813260-27-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-159805. | |
| CDK2-IN-4 | CDK2-IN-4 (compound 73) is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2079895-42-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117535. | |
| CDK2 inhibitor II | CDK2 inhibitor II. Group: Biochemicals. Alternative Names: 4- [2- (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazinyl] benzenesulfonamide; 4- [ (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazino] benzenesulfonamide; SC 221409. Grades: Highly Purified. CAS No. 222035-13-4. Pack Sizes: 5mg. Molecular Formula: C14H11BrN4O3S, Molecular Weight: 395.23. US Biological Life Sciences. | Worldwide |
| CDK2/MDM2-IN-1 | CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC50 value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3083904-06-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163357. | |
| CDK4/6-IN-18 | CDK4/6-IN-18 (Example 2BrIC) is a selective CDK4/6 inhibitor. CDK4/6-IN-18 inhibits ionizing radiation (IR)-induced DNA damage in cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 546102-60-7. Pack Sizes: 500 μg; 1 mg. Product ID: HY-112418. | |
| CDK4/6-IN-2 | CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor extracted from patent US20180000819A1, Compound 1, has IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1800506-48-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114339. | |
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