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| Product | Description | |
|---|---|---|
| EPZ005687 | EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, and has 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1396772-26-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15555. |  |
| EPZ005687 | EPZ005687 is a selective EZH2 enzyme inhibitor with Ki of 24 nM. It is 50-fold selectivity against EZH1 and 500-fold selectivity against 15 other protein methyltransferases. EPZ005687 can block trimethylation of the PRC2 target histone 3 lysine 27 with IC50 value of 80 nM, decreasing the proliferation of lymphoma cells carrying mutant, but not wild-type, EZH2. No development of preclinical research for the treatment of Cancer, Lymphoma and Solid tumours was reported. Uses: Cancer; lymphoma; solid tumours. Synonyms: EPZ005687; EPZ 005687; EPZ-005687; 1-Cyclopentyl-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-6-[4-(4-morpholinylmethyl)phenyl]-1H-indazole-4-carboxamide; 1-Cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide. Grade: 98%. CAS No. 1396772-26-1. Molecular formula: C32H37N5O3. Mole weight: 539.67. |  |
| EPZ011989 | EPZ011989 is a potent, orally-available EZH2 inhibitor with robust in vivo activity. EPZ011989 demonstrates significant tumor growth inhibition in a mouse xenograft model of human B cell lymphoma. Synonyms: EPZ011989; EPZ-011989; EPZ 011989. Grade: 98%. CAS No. 1598383-40-4. Molecular formula: C35H51N5O4. Mole weight: 605.82. | |
| EPZ011989 trifluoroacetate | EPZ011989 trifluoroacetate is the trifluoroacetate salt form of EPZ011989. EPZ011989 is a potent and orally bioavailable inhibitor that specifically targets the protein methyltransferase Enhancer of Zeste Homolog 2 (EZH2), with significant tumor growth in. Synonyms: EPZ011989 TFA salt; EPZ011989 TFA; EPZ 011989 TFA; EPZ-011989 TFA; N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl(methyl)amino]cyclohexyl]amino]-2-methyl-5-(3-morpholin-4-ylprop-1-ynyl)benzamide; 2,2,2-trifluoroacetic acidEPZ011989 (trifluoroacetate). CAS No. 1598383-41-5. Molecular formula: C37H52F3N5O6. Mole weight: 719.83. | |
| EPZ015666 | EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. Synonyms: EPZ015666; EPZ-015666; EPZ 015666; GSK3235025; GSK-3235025; GSK 3235025. Grade: >98%. CAS No. 1616391-65-1. Molecular formula: C20H25N5O3. Mole weight: 383.44. | |
| EPZ015666 | EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC50 of 22 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK3235025. CAS No. 1616391-65-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12727. | |
| EPZ015866 | EPZ015866,also called as GSK591, is a chemical probe for PRMT5 which has a role in diverse cellular processes including tumorigenesis. It exhibits excellent selectivity against a panel of methyltransferases. Inhibits the PRMT5/MEP50 complex from methylati. Synonyms: GSK591; GSK-591; GSK 591; EPZ015866; EPZ-015866; EPZ 015866; GSK 3203591; GSK-3203591; GSK3203591; 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamideEPZ015866GSK591GTPL8954SCHEMBL16220740GSK32035912-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carbo. CAS No. 1616391-87-7. Molecular formula: C22H28N4O2. Mole weight: 380.48. | |
| EPZ020411 | EPZ020411, with potent anticancer activity, is an orally bioactive, selective inhibitor of PRMT6/8/1 with over 100-fold selective for other histone methyltransferases including four arginine methyltransferases (PRMT3, PRMT4, PRMT5, and PRMT7). Synonyms: N,N'-dimethyl-N'-[[5-[4-[3-[2-(oxan-4-yl)ethoxy]cyclobutyl]oxyphenyl]-1H-pyrazol-4-yl]methyl]ethane-1,2-diamineEPZ020411; EPZ 020411; EPZ-020411CHEMBL3589039GTPL9243SCHEMBL1762195749LN,N'-Dimethyl-N-({3-[4-({trans-3-[2-(Tetrahydro-2h-Pyran-4-Yl)ethoxy]cyclobutyl}oxy)phenyl. CAS No. 1700663-41-7. Molecular formula: C25H38N4O3. Mole weight: 442.59. | |
| EPZ020411 | EPZ020411 is a selective inhibitor of PRMT6 with an IC50 of 10 nM, has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1700663-41-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12970. | |
| EPZ020411 HCl | EPZ020411 hydrochloride is a potent and selective small molecule PRMT6 inhibitor with an IC50 of 10 nM, and it displays >10-fold and 20-fold selectivity over PRMT1/8. Synonyms: EPZ-020411 hydrochloride. Grade: ≥97%. CAS No. 2070015-25-5. Molecular formula: C25H39ClN4O3. Mole weight: 479.06. | |
| EPZ031686 | EPZ031686 is an potent and orally active SMYD3 inhibitor and with an IC50 value of 3 nM. EPZ031686 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095161-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19324. | |
| EPZ-5676 | EPZ-5676 is a small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676 specifically blocks the activity of the histone lysine-methyltransferase DOT1L, thereby inhibiting the methylation of nucleosomal histone H3 on lysine 79 (H3K79) that is bound to the mixed lineage leukemia (MLL) fusion protein which targets genes and blocks the expression of leukemogenic genes. This eventually leads to an induction of apoptosis in the leukemic cells bearing the MLL gene translocations. DOT1L, a non-SET domain-containing histone methyltransferase, specifically methylates H3K79 and plays a key role in normal cell differentiation and in the development of leukemia with MLL gene rearrangement on chromosome 11 and promotes the expression of leukemia-causing genes. Synonyms: EPZ-5676; EPZ5676; EPZ 5676. CAS No. 1380288-87-8. Molecular formula: C30H42N8O3. Mole weight: 562.719. | |
| EPZ-6438 | EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers. EPZ-6438 is currently in clinical trials. Synonyms: EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat. Grade: 98%. CAS No. 1403254-99-8. Molecular formula: C34H44N4O4. Mole weight: 572.75. | |
| EPZ-6438 (Tazemetostat) | Tazemetostat (EPZ-6438, E7438) is a potent, and selective EZH2 inhibitor with Ki and IC50 of 2.5 nM and 11 nM in cell-free assays, exhibiting a 35-fold selectivity versus EZH1 and >4,500-fold selectivity relative to 14 other HMTs. Group: Inhibitors. Alternative Names: E7438. CAS No. 1403254-99-8. Pack Sizes: 10mg. Product ID: S7128. Formula: C34H44N4O4. Smiles: CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCOCC5. Storage Conditions: 2 years -80 in solvent. |  United States; Europe |
| EPZ-719 | EPZ-719 is a selective, orally effective SETD2 inhibitor with an IC50 value of 0.005 μM. EPZ-719 has anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2697176-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139626. | |
| Equilenin | Equilenin. Group: Biochemicals. Alternative Names: 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one; (+)-Equilenin; 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one. Grades: Highly Purified. CAS No. 517-09-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C18H18O2. US Biological Life Sciences. |  Worldwide |
| Equilenin | Equilenin is an estrogenic steroid hormone obtained from the urine of pregnant mares. Synonyms: 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one; (+)-Equilenin; 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one. Grade: > 95%. CAS No. 517-09-9. Molecular formula: C18H18O2. Mole weight: 266.34. | |
| Equilenin-[4,16,16-d3] | Equilenin-[4,16,16-d3] is the labelled analogue of Equilenin, which is an estrogenic steroid hormone obtained from the urine of pregnant mares. Synonyms: Equilenin D3; 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one-d3; (+)-Equilenin-d3; 3-Hydroxyestra-1,3,5(10),6,8-pentaen-17-one-d3; Equilenine-d3; NSC 9901-d3; d-Equilenin-d3; Estra-1,3,5,7,9-pentaen-17-one-4,16,16-d3, 3-hydroxy-. Grade: ≥95%; ≥97% atom D. CAS No. 56588-54-6. Molecular formula: C18H15D3O2. Mole weight: 269.35. | |
| Equilenin solution | Equilenin solution. Alternative Names: Equilenin solution; EQU; Equilenina; d-Equilenin. CAS No. 517-09-9. Purity: analytical standard. Product ID: ACM517099. Molecular formula: C18H18O2. Mole weight: 266.33. IUPAC Name: (13S,14S)-3-hydroxy-13-methyl-12,14,15,16-tetrahydro-11H-cyclopenta[a]phenanthren-17-one. Canonical SMILES: CC12CCC3=C(C1CCC2=O)C=CC4=C3C=CC(=C4)O. ECNumber: 208-230-5. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Equilenin Sulfate Sodium | A metabolite of Equilin. Equilenin is an estrogenic steroid hormone obtained from the urine of pregnant mares. Synonyms: 3-(Sulfooxy)-estra-1,3,5,7,9-pentaen-17-one Sodium Salt; 3-Hydroxyestra-1,3,5,7,9-pentaen-17-one HydrogenSulfate Monosodium Salt. Grade: > 95%. CAS No. 16680-48-1. Molecular formula: C18H17FO5S Na. Mole weight: 345.40 22.99. | |
| Equilin | Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Uses: An estrogen. Synonyms: 3-Hydroxy-13-methyl-9,11,12,14,15,16-hexahydro-6H-cylcopenta(a)phenanthren-17-one. Grade: > 95%. CAS No. 474-86-2. Molecular formula: C18H20O2. Mole weight: 268.36. | |
| Equilin | An estrogen found in Premarin, which is a mixture of conjugated estrogens widely used in hormone replacement therapy. Group: Biochemicals. Alternative Names: 1,3,5,7-Estratetraen-3-ol-17-one; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one; 7-Dehydroestrone; NSC 10971. Grades: Highly Purified. CAS No. 474-86-2. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Equilin-[2,4,16,16-d4] | Equilin-[2,4,16,16-d4] is the labelled analogue of Equilin, which is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: Equilin-2,4,16,16-d4; 1,3,5,7-Estratetraen-3-ol-17-one-d4; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one-d4; 7-Dehydroestrone-d4; NSC 10971-d4; Equilin-d4. Grade: >95%; 98% atom D. CAS No. 285979-79-5. Molecular formula: C18H16D4O2. Mole weight: 272.38. | |
| Equilin 3-Benzoate | Estrogen derivative. Displays inhibiton activity towards pig liver steroid Δ4-5 β-reductase. Group: Biochemicals. Alternative Names: 3-(Benzoyloxy)-estra-1,3,5(10),7-tetraen-17-one; 3-Hydroxy-estra-1,3,5(10),7-tetraen-17-one Benzoate. Grades: Highly Purified. CAS No. 6030-80-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Equilin 3-Benzoate | Equilin 3-Benzoate is an intermediate of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 3-(Benzoyloxy)-estra-1,3,5(10),7-tetraen-17-one; 3-Hydroxy-estra-1,3,5(10),7-tetraen-17-one Benzoate; Equilin benzoate; 17-Oxoestra-1,3,5(10),7-tetraen-3-yl benzoate; Estra-1,3,5(10),7-tetraen-17-one, 3-(benzoyloxy)-; Equilin Impurity 10. Grade: ≥95%. CAS No. 6030-80-4. Molecular formula: C25H24O3. Mole weight: 372.46. | |
| Equilin 3-O-β-D-glucuronide | An impurity of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl β-D-glucopyranosiduronic acid. CAS No. 76663-60-0. Molecular formula: C24H28O8. Mole weight: 444.47. | |
| Equilin 3-O-beta-D-Glucuronide Sodium Salt | A derivative of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl β-D-Glucopyranosiduronic Acid Monosodium Salt. Grade: > 95%. CAS No. 27610-12-4. Molecular formula: C24H27O8.Na. Mole weight: 466.46. | |
| Equilin 3-sulfate-[2,4,16,16-d4] sodium salt | Equilin 3-sulfate-[2,4,16,16-d4] sodium salt is the labelled analogue of Equilin 3-sulfate sodium salt, which is a metabolite of Equilin. Synonyms: Sodium equilin-3-sulfate-2,4,16,16-d4; Equilin-2,4,16,16-d4 3-sulfate sodium salt; 3-(Sulfooxy)estra-1,3,5(10),7-tetraen-17-one-d4 Sodium Salt; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one-d4 Hydrogen Sulfate Sodium Salt; Sodium Equilin-d4 3-Monosulfate; Sodium Equilin-d4 Sulfate. Grade: ≥99% by CP; ≥97% atom D. CAS No. 285979-81-9. Molecular formula: C18H15D4O5S.Na. Mole weight: 374.42. | |
| Equilin 3-Sulfate-d4 Sodium Salt (stabilized with Tris, 50% w/w) | A labeled metabolite of Equilin. Group: Biochemicals. Alternative Names: 3-(Sulfooxy)estra-1,3,5(10),7-tetraen-17-one-d4 Sodium Salt; t; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one-d4 Hydrogen Sulfate Sodium Salt; Sodium Equilin-d4 3-Monosulfate; Sodium Equilin-d4 Sulfate. Grades: Highly Purified. CAS No. 285979-81-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Equilin 3-sulfate sodium salt | Equilin 3-sulfate sodium salt. Group: Biochemicals. Alternative Names: 3-(Sulfooxy)estra-1,3,5(10),7-tetraen-17-one sodium salt; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one hydrogen sulfate sodium salt; Sodium equilin 3-monosulfate. Grades: Highly Purified. CAS No. 16680-47-0. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C18H19NaO5S. US Biological Life Sciences. | Worldwide |
| Equilin 3-Sulfate Sodium Salt | A derivative of Equilin. Equilin is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Uses: Estrogens. Synonyms: 3-(Sulfooxy)estra-1,3,5(10),7-tetraen-17-one Sodium Salt; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one Hydrogen Sulfate Sodium Salt; Sodium Equilin 3-Monosulfate. Grade: > 95%. CAS No. 16680-47-0. Molecular formula: C18H19O5S. Na. Mole weight: 370.4. | |
| Equilin 3-Sulfate Sodium Salt (Stabilized with Tris, 50% w/w) | Metabolite of Equilin. Equilin 3-Sulfate Sodium Salt (Stabilized with TRIS, 50% w/w). Group: Biochemicals. Alternative Names: 3-(Sulfooxy)estra-1,3,5(10),7-tetraen-17-one Sodium Salt; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one Hydrogen Sulfate Sodium Salt; Sodium Equilin 3-Monosulfate; Sodium Equilin Sulfate. Grades: Highly Purified. CAS No. 16680-47-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Equilin-d4 | Labeled Equilin. An estrogen found in Premarin, which is a mixture of conjugated estrogens widely used in hormone replacement therapy. Group: Biochemicals. Alternative Names: 1,3,5,7-Estratetraen-3-ol-17-one-d4; 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one-d4; 7-Dehydroestrone-d4; NSC 10971-d4. Grades: Highly Purified. CAS No. 285979-79-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Equilin-d4 3-beta-O-D-Glucuronide Sodium Salt | One of the isotope labelled derivative of Equilin, which is one of the estrogens present in the mixture of estrogens isolated from horse urine and marketed as Premarin. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl β-D-Glucopyranosiduronic Acid Monosodium Salt-d4. Molecular formula: C24H23O8D4.Na. Mole weight: 470.49. | |
| Equilin Sulfate | Equilin Sulfate is a metabolite of Equilin, which is an estrogen, or an agonist of the estrogen receptors ERα and ERβ. Synonyms: 17-Oxoestra-1,3,5(10),7-tetraen-3-yl hydrogen sulfate; Estra-1,3,5(10),7-tetraen-17-one, 3-(sulfooxy)-; [(9S,13S,14S)-17-keto-13-methyl-9,11,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate. Grade: 95%. CAS No. 27540-07-4. Molecular formula: C18H20O5S. Mole weight: 348.41. | |
| equine arterivirus serine peptidase | In the equine arterivirus (EAV), the replicase gene is translated into open reading frame 1a (ORF1a) and ORF1ab polyproteins. This enzyme is the main viral proteinase and processes five cleavage sites in the ORF1a protein and three in the ORF1b-encoded part of the ORF1ab protein to yield nonstructural proteins (nsp5-nsp12). It combines the catalytic system of a chymotrypsin-like serine peptidase (His-Asp-Ser catalytic triad) with the substrate specificity of a 3C-like serine peptidase (Glu or Gln) at the P1 position and a small amino-acid residue (Gly, Ser or Ala) at the P1' position. Cleavage of ORF1ab by this enzyme is essential for viral replication. Belongs in peptidase family S32. Group: Enzymes. Enzyme Commission Number: EC 3.4.21.114. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4109; equine arterivirus serine peptidase; EC 3.4.21.114. Cat No: EXWM-4109. |  |
| Equisetin | The tetramic acid equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against human immunodeficiency virus type 1 (HIV-1) integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core. Group: Biochemicals. Grades: Highly Purified. CAS No. 57749-43-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Equisetin | Equisetin is an antibiotic produced by Fusarium equiseti NRRL 5537. Activity against gram-positive bacteria. Synonyms: (-)-Equisetin. Grade: >98%. CAS No. 57749-43-6. Molecular formula: C22H31NO4. Mole weight: 373.48. | |
| Equisetin | Equisetin is an N-methylserine-derived acyl tetramic acid, quorum sensing inhibitor (QSI), herbicides and antibiotics. Equisetin specifically inhibits the anionic carriers of substrates in the inner mitochondrial membrane. Equisetin inhibits the activity of HIV-1 integrase, 11β-HSD1, and 2,4-dinitrophenol (Dnp)-stimulated ATPase (IC50 = ~8 nmol per mg of protein). Equisetin exhibits growth inhibition of bacteria, anti-inflammatory, amelioration of lipid-associated disorders, and cytotoxic effects[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57749-43-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6711. | |
| ER-000444793 | ER-000444793, a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening, inhibits mPTP with an IC50 of 2.8?μM. R-000444793 neither affected cyclophilin D (CypD) enzymatic activity, nor displaced of CsA from CypD protein, suggesting a mechanism independent of CypD inhibition. Synonyms: N-(2-benzylphenyl)-2-oxo-1H-quinoline-4-carboxamide; ER-000444793; ER 000444793; ER000444793. CAS No. 792957-74-5. Molecular formula: C23H18N2O2. Mole weight: 354.4. | |
| ER-000444793 | ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. ER-000444793 inhibits mPTP with an IC50 of 2.8 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 792957-74-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100852. | |
| ER-076349 | ER-076349 (Eribulin intermediate) is an inhibitor of tubulin polymerization, induces G2-M cell cycle arrest, and disrupts mitotic spindles. ER-076349 inhibits cancer cell growth, and inhibits tumor growth in several human tumor xenografts. ER-076349 is an analog of Halichondrin B[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Eribulin intermediate. CAS No. 253128-15-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-42484. | |
| ER 27319 | ER 27319 is a selective PLK-1 and Syk kinase inhibitor. Synonyms: 9(10H)-Acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, ethanedioate (1:1); 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone ethanedioate (1:1); 3,4-Dimethyl-10-(3-aminopropyl)-9-acridone Oxalate; ER27319; ER-27319; 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate; ER 27319 Oxalate. Grade: ≥95%. CAS No. 201010-95-9. Molecular formula: C18H20N2O.C2H2O4. Mole weight: 370.40. | |
| ER 27319 maleate | ER 27319 maleate is a selective Syk kinase inhibitor. It suppresses tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells, causing the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events. Synonyms: ER27319 maleate; ER-27319 maleate; 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate; 9(10H)-Acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, (2Z)-2-butenedioate (1:1); 3,4-Dimethyl-10-(3-aminopropyl)-9-acridone maleate. Grade: ≥99% by HPLC. CAS No. 1204480-26-1. Molecular formula: C18H20N2O.C4H4O4. Mole weight: 396.17. | |
| ER 27319 maleate | ER 27319 maleate. Group: Biochemicals. Grades: Purified. CAS No. 1204480-26-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ER 50891 | ER 50891. Group: Biochemicals. Grades: Purified. CAS No. 187400-85-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ER 50891 | ER 50891 is an RARα receptor antagonist (IC50 = 31.2 nM). Synonyms: ER 50891; ER50891; ER-50891; 4-[5-[8-(1-Methylethyl)-4-phenyl-2-quinolinyl]-1H-pyrrolo-2-benzoic acid. Grade: ≥99% by HPLC. CAS No. 187400-85-7. Molecular formula: C29H24N2O2. Mole weight: 432.51. | |
| ER-67880 | ER-67880 is a novel and potent microtubule inhibitor with potential anticancer activity. Synonyms: ER 67880; ER67880; N-(3-chloro-1H-indol-7-yl)-4-methoxy-benzenesulfonamide. Grade: 98%. CAS No. 247186-96-5. Molecular formula: C15H13ClN2O3S. Mole weight: 336.79. | |
| ER-805751 | ER-805751 is a potent proteasome inhibitor. Synonyms: ER-80575; ER805751; ER 805751. Grade: 98%. CAS No. 565454-88-8. Molecular formula: C25H30N2O6. Mole weight: 454.52. | |
| ER 819762 | ER 819762 is a potent and selective EP4 receptor antagonist (IC50 = 59 nM) that inhibits EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. It was shown to suppress Th1 and Th17 cytokine production, collagen- and GPI-induced arthritis in mice. It attenuates CFA-induced inflammatory pain in rats. Uses: Analgesic. Synonyms: ER819762; ER 819762; ER-819762. (10S)-1'-[(3,5-Dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methylspiro[1H-imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one. Grade: ≥98% by HPLC. CAS No. 1155773-15-1. Molecular formula: C30H39N3O3. Mole weight: 489.65. | |
| ER-878898 | Gemcitabine intermediate. Uses: Gemcitabine intermediate. Synonyms: 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate 1-Methanesulfonate. Grade: 97%. CAS No. 122111-11-9. Molecular formula: C20H18F2O8S. Mole weight: 456.41. | |
| ERA63 | A selective agonist of estrogen receptor α. Synonyms: ERA63; ERA 63; ERA-63; (7R,8R,9S,13S,14S,17R)-17-ethynyl-7,13-dimethyl-3-methylidene-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol. CAS No. 343248-86-2. Molecular formula: C22H30O. Mole weight: 310.47. | |
| Erabulenol A | Erabulenol A is a cholesteryl ester transfer protein (CETP) inhibitor produced by Penicillum sp. FO-5637. Synonyms: Deoxyherqueinone; Atrovenetin monomethyl ether. CAS No. 20887-73-4. Molecular formula: C20H20O6. Mole weight: 356.37. | |
| Erabulenol B | Erabulenol B is a cholesteryl ester transfer protein (CETP) inhibitor produced by Penicillum sp. FO-5637. Molecular formula: C30H30O10. Mole weight: 550.55. | |
| Eragidomide | Eragidomide Inhibitor. Uses: Scientific use. Product Category: T10765. CAS No. 1860875-51-9. |  |
| Eragidomide | Eragidomide is a modulator of the E3 ligase cereblon and has antineoplastic activity. Synonyms: rac-2-(4-chlorophenyl)-N-({2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide; CC-90009; Cereblon modulator 1; NSC828250; CC 90009; CC90009; 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-benzeneacetamide. Grade: ≥98% by HPLC. CAS No. 1860875-51-9. Molecular formula: C22H18ClF2N3O4. Mole weight: 461.85. | |
| Eragidomide | Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-90009. CAS No. 1860875-51-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-130800. | |
| ERα degrader-2 | ERα degrader-2, a selective estrogen receptor degrader (SERD), has a strong binding affinity with ERα (IC50 = 17.1 nM) and a good degradation efficacy (EC50 = 0.3 nM). It has good pharmacokinetic properties and druggability, and can be used in the study of HER+ breast cancer. Synonyms: [1,1'-Biphenyl]-4-carboxylic acid, 3',5'-difluoro-4'-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]-. CAS No. 2235396-63-9. Molecular formula: C29H27F3N2O2. Mole weight: 492.53. | |
| ERAP1-IN-1 | ERAP1-IN-1 is an inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme that trims peptides loaded into classical and nonclassical MHC Class I molecules. Synonyms: ERAP1 inhibitor compound 3; 4-Methoxy-3-(N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid. Grade: 99%. CAS No. 865273-97-8. Molecular formula: C20H21F3N2O5S. Mole weight: 458.45. | |
| ERAS-0015 | ERAS-0015(JYP0015) is a tricomplex inhibitor of panRAS(ON) targeting of active RAS, it binds to Cyclophilin A (CYPA) to form a high-affinity complex that sterically occludes RAS-effector interactions. It exhibits potential for research in RAS-mutant solid tumors. Group: Inhibitors. Alternative Names: JYP0015. CAS No. 3034673-92-9. Pack Sizes: 1mg. Product ID: E5848. Formula: C46H60N8O5S. | United States; Europe |
| Eras-4001 | Eras-4001 (Compound 14-1) is a pan-KRAS inhibitor. Eras-4001 has potent antitumor activities and significantly inhibits the proliferation of wild-type and mutant (such as KRASG12D, KRASG12V and KRASG12C) cancer cells. Eras-4001 effectively inhibits tumor growth in GP2D and Panc0403 xenograft mouse models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3024878-19-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-175870. | |
| Erasin | Erasin is a potent Erlotinib (HY-50896)-resistance antagonizing STAT3 inhibitor with IC50s of 9.7 and 24 μM against STAT3 and STAT1, respectively. Erasin induces cancer cells apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2256056-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-115594. | |
| Erastin | Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation[1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Uses: Scientific research. Category: Signaling pathways. CAS No. 571203-78-6. Pack Sizes: 1 mg; 1 mg * 5; 1 mg * 10. Product ID: HY-15763. | |
| Erastin | Erastin Inhibitor. Uses: Scientific use. Product Category: T1765. CAS No. 571203-78-6. | |
| Erastin | Erastin is a selective antitumor agent that displays greater lethality in human tumor cells harboring mutations in the oncogenes HRAS, KRAS or BRAF. It binds to mitochondrial volatage-dependent anion channels (VDAC) proteins, more specifically on VDAC2 and alters its gating. Erastin rapidly induces an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling. Group: Biochemicals. Alternative Names: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone. Grades: Highly Purified. CAS No. 571203-78-6. Pack Sizes: 1mg. Molecular Formula: C??H??ClN?O?, Molecular Weight: 547.04. US Biological Life Sciences. | Worldwide |
| Erastin | Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Solutions are unstable and should be fresh-prepared. Group: Inhibitors. CAS No. 571203-78-6. Pack Sizes: 5mg. Product ID: S7242. Formula: C30H31ClN4O4. Smiles: CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl. | United States; Europe |
| Erastin | Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces non-apoptotic tumor cell death by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. Reversal of tubulin-VDAC interaction by erastin antagonizes Warburg metabolism and restores oxidative mitochondrial metabolism. Synonyms: Erastin. Grade: 0.98. CAS No. 571203-78-6. Molecular formula: C30H31ClN4O4. Mole weight: 547.04454. | |
| Erastin2 | Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter, which inhibits glutamate release in CCF-STTG1 cells with an IC50 of 0.0035 μM. Synonyms: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-4(3H)-quinazolinone. Grade: ≥98%. CAS No. 1695533-44-8. Molecular formula: C36H35ClN4O4. Mole weight: 623.14. | |
| Erastin2 | Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1695533-44-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139087. | |
| Erastin impurity 2 | Erastin impurity 2. Uses: For analytical and research use. Molecular formula: C16H22N4O2. Mole weight: 302.38. Catalog: APB11220. |  |
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