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| Product | Description | |
|---|---|---|
| Erlotinib Impurity 39 | Erlotinib Impurity 39. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-chloro-6-(2-chloroethoxy)-7-(2-methoxyethoxy)quinazoline. CAS No. 183322-19-2. Molecular Formula: C13H14Cl2N2O3. Mole Weight: 317.17. Catalog: APB183322192. |  |
| Erlotinib impurity 4 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 3-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)benzoic acid. Grades: > 95%. Molecular formula: C21H23N3O6. Mole weight: 413.43. |  |
| Erlotinib impurity 4 | Erlotinib impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 183320-19-6. Molecular Formula: C21H21Cl2N3O3. Mole Weight: 434.32. Catalog: APB183320196. | |
| Erlotinib Impurity 40 | Erlotinib Impurity 40. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C22H28ClN3O4. Mole Weight: 433.93. Catalog: APB05342. | |
| Erlotinib Impurity 41 | Erlotinib Impurity 41. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C21H21Cl2N3O3. Mole Weight: 434.32. Catalog: APB05338. | |
| Erlotinib Impurity 42 | Erlotinib Impurity 42. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-(3-Amino-phenyl)-2,3-dibromo-propionic acid. Molecular Formula: C9H9Br2NO2. Mole Weight: 322.98. Catalog: APB05339. | |
| Erlotinib Impurity 44 | Erlotinib Impurity 44. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-6-methoxy-7-(2-methoxyethoxy)quinazolin-4-amine. Molecular Formula: C20H19N3O3. Mole Weight: 349.38. Catalog: APB05337. | |
| Erlotinib Impurity 45 | Erlotinib Impurity 45. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(3-aminophenyl)ethanone. CAS No. 99-03-6. Molecular Formula: C8H9NO. Mole Weight: 135.16. Catalog: APB99036. | |
| Erlotinib Impurity 47 | Erlotinib Impurity 47. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 8-chloro-N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C22H23Cl2N3O4. Mole Weight: 464.34. Catalog: APB05335. | |
| Erlotinib Impurity 48 | Erlotinib Impurity 48. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-ethynylphenyl)amino)quinazoline-6,7-diol hydrochloride. Molecular Formula: C16H12ClN3O2. Mole Weight: 313.74. Catalog: APB05334. | |
| Erlotinib Impurity 49 | Erlotinib Impurity 49. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 4-hydroxybenzoate. Molecular Formula: C9H10O3. Mole Weight: 166.17. Catalog: APB05332. | |
| Erlotinib Impurity 5 | Erlotinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethyl acetate. CAS No. 183320-15-2. Molecular Formula: C23H23N3O5. Mole Weight: 421.16. Catalog: APB183320152. | |
| Erlotinib Impurity 5 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6,7-bis(2-methoxyethoxy)-N-phenylquinazolin-4-amine. Grades: > 95%. Molecular formula: C20H25N3O4. Mole weight: 369.42. | |
| Erlotinib Impurity 50 | Erlotinib Impurity 50. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 3-hydroxybenzoate. Molecular Formula: C9H10O3. Mole Weight: 166.17. Catalog: APB05333. | |
| Erlotinib Impurity 51 | Erlotinib Impurity 51. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ethyl 2-amino-4,5-dihydroxybenzoate. Molecular Formula: C9H11NO4. Mole Weight: 197.19. Catalog: APB05331. | |
| Erlotinib Impurity 52 | Erlotinib Impurity 52. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-dihydroxyquinazolin-4(3H)-one. Molecular Formula: C8H6N2O3. Mole Weight: 178.14. Catalog: APB01899. | |
| Erlotinib Impurity 53 | Erlotinib Impurity 53. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-amino-N-formyl-4,5-bis(2-methoxyethoxy)benzamide hydrochloride. Molecular Formula: C14H21ClN2O6. Mole Weight: 348.78. Catalog: APB05329. | |
| Erlotinib Impurity 54 | Erlotinib Impurity 54. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-chloroquinazoline-6,7-diol. Molecular Formula: C8H5ClN2O2. Mole Weight: 196.59. Catalog: APB05330. | |
| Erlotinib Impurity 55 | Erlotinib Impurity 55. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: potassium 5-(ethoxycarbonyl)-2-(2-methoxyethoxy)phenolate. Molecular Formula: C12H15KO5. Mole Weight: 278.34. Catalog: APB05327. | |
| Erlotinib Impurity 56 | Erlotinib Impurity 56. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: potassium 4-(ethoxycarbonyl)-2-(2-methoxyethoxy)phenolate. Molecular Formula: C12H15KO5. Mole Weight: 278.34. Catalog: APB05328. | |
| Erlotinib Impurity 57 | Erlotinib Impurity 57. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: potassium 3,4-bis(2-methoxyethoxy)benzoate. Molecular Formula: C13H17KO6. Mole Weight: 308.37. Catalog: APB05326. | |
| Erlotinib Impurity 58 | Erlotinib Impurity 58. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Protocatechuic Acid; 3,4-dihydroxybenzoic acid. CAS No. 99-50-3. Molecular Formula: C7H6O4. Mole Weight: 154.12. Catalog: APB99503. | |
| Erlotinib Impurity 59 | Erlotinib Impurity 59. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-bis(2-methoxyethoxy)-N,N-dimethylquinazolin-4-amine. Molecular Formula: C16H23N3O4. Mole Weight: 321.37. Catalog: APB05325. | |
| Erlotinib impurity 6 | Erlotinib impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 183320-51-6. Molecular Formula: C21H22ClN3O4. Mole Weight: 415.87. Catalog: APB183320516. | |
| Erlotinib Impurity 6 | Erlotinib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,2'-((4-((3-ethynylphenyl)amino)quinazoline-6,7-diyl)bis(oxy))diethanol hydrochloride. CAS No. 183320-12-9. Molecular Formula: C20H20ClN3O4. Mole Weight: 401.11. Catalog: APB183320129. | |
| Erlotinib Impurity 60 | Erlotinib Impurity 60. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-amino-4,5-bis(2-methoxyethoxy)benzoic acid. Molecular Formula: C13H19NO6. Mole Weight: 285.29. Catalog: APB01898. | |
| Erlotinib Impurity 61 | Erlotinib Impurity 61. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-ol. Molecular Formula: C19H17N3O3. Mole Weight: 335.36. Catalog: APB05324. | |
| Erlotinib Impurity 62 | Erlotinib Impurity 62. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3,4-bis(2-methoxyethoxy)-5-nitrobenzonitrile. CAS No. 180031-38-3. Molecular Formula: C13H16N2O6. Mole Weight: 296.28. Catalog: APB180031383. | |
| Erlotinib impurity, 6-(2-chloroethoxy)-7-(2-methoxyethoxy) | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-methoxyethoxy)-4-Quinazolinamine. Grades: > 95%. CAS No. 183321-85-9. Molecular formula: C21H20ClN3O3. Mole weight: 397.86. | |
| Erlotinib impurity, 6-(2-methoxyethoxy)-7-(2-chloroethoxy) | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6-(2-chloroethoxy)-N-(3-ethynylphenyl)-7-(2-methoxyethoxy)quinazolin-4-amine. Grades: > 95%. CAS No. 183321-83-7. Molecular formula: C21H20ClN3O3. Mole weight: 397.86. | |
| Erlotinib Impurity 63 | Erlotinib Impurity 63. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3,4-bis(2-methoxyethoxy)-2-nitrobenzonitrile. Molecular Formula: C13H16N2O6. Mole Weight: 296.28. Catalog: APB01896. | |
| Erlotinib Impurity 64 | Erlotinib Impurity 64. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-amino-4,5-bis(2-methoxyethoxy)benzonitrile. Molecular Formula: C13H18N2O4. Mole Weight: 266.29. Catalog: APB05323. | |
| Erlotinib Impurity 65 | Erlotinib Impurity 65. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-amino-3,4-bis(2-methoxyethoxy)benzonitrile. Molecular Formula: C13H18N2O4. Mole Weight: 266.29. Catalog: APB01897. | |
| Erlotinib Impurity 66 | Erlotinib Impurity 66. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-imine. Molecular Formula: C22H23N3O4. Mole Weight: 393.44. Catalog: APB05322. | |
| Erlotinib Impurity 67 | Erlotinib Impurity 67. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-methoxyethoxy)quinazolin-4-amine. CAS No. 183321-85-9. Molecular Formula: C21H20ClN3O3. Mole Weight: 397.85. Catalog: APB183321859. | |
| Erlotinib impurity, 6,7-bis(2-chloroethoxy) | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine. Grades: > 95%. CAS No. 183321-82-6. Molecular formula: C20H17Cl2N3O2. Mole weight: 402.28. | |
| Erlotinib Impurity 68 | Erlotinib Impurity 68. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine. CAS No. 183321-82-6. Molecular Formula: C20H17Cl2N3O2. Mole Weight: 402.27. Catalog: APB183321826. | |
| Erlotinib Impurity 69 | Erlotinib Impurity 69. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2518426-66-7(free base); ethyl 3-amino-4,5-bis(2-methoxyethoxy)benzoate hydrochloride. Molecular Formula: C15H23NO6·HCl. Mole Weight: 349.81. Catalog: APB01106. | |
| Erlotinib Impurity 7 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2-amino-4,5-bis(2-methoxyethoxy)benzoic acid ethyl ester hydrochloride. Grades: > 95%. CAS No. 183322-17-0. Molecular formula: C15H23NO6 HCl. Mole weight: 349.81. | |
| Erlotinib Impurity 7 | Erlotinib Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 6,7-bis(2-methoxyethoxy)-N-(3-vinylphenyl)quinazolin-4-amine hydrochloride. CAS No. 1624294-38-7. Molecular Formula: C22H26ClN3O4. Mole Weight: 431.16. Catalog: APB1624294387. | |
| Erlotinib Impurity 70 | Erlotinib Impurity 70. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-amino-4,5-bis(2-methoxyethoxy)benzaldehyde. CAS No. 1494468-76-6. Molecular Formula: C13H19NO5. Mole Weight: 269.29. Catalog: APB1494468766. | |
| Erlotinib Impurity 71 | Erlotinib Impurity 71. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N-(3-ethynylphenyl)acetamide. CAS No. 2055840-54-3. Molecular Formula: C24H25N3O5. Mole Weight: 435.47. Catalog: APB2055840543. | |
| Erlotinib Impurity 74 | Erlotinib Impurity 74. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4,5-bis(2-methoxyethoxy)-2-nitrobenzoic acid. CAS No. 1001416-73-4. Molecular Formula: C13H17NO8. Mole Weight: 315.28. Catalog: APB1001416734. | |
| Erlotinib Impurity 75 | Erlotinib Impurity 75. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: quinazoline-4,6,7-triol. CAS No. 16064-15-6. Molecular Formula: C8H6N2O3. Mole Weight: 178.14. Catalog: APB16064156. | |
| Erlotinib Impurity 76 | Erlotinib Impurity 76. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-2-(((dimethylamino)methylene)amino)-4,5-bis(2-methoxyethoxy)benzamide. CAS No. 1241475-15-9. Molecular Formula: C16H25N3O5. Mole Weight: 339.39. Catalog: APB1241475159. | |
| Erlotinib Impurity 8 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: N-(3-Desethynylphenyl)-N-(3-bromophenyl) Erlotinib; N-(3-bromophenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine. Grades: > 95%. CAS No. 328528-74-1. Molecular formula: C20H22BrN3O4. Mole weight: 448.32. | |
| Erlotinib Impurity 8 | Erlotinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynyl-4-methylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride. CAS No. 1346601-52-2. Molecular Formula: C23H26ClN3O4. Mole Weight: 443.16. Catalog: APB1346601522. | |
| Erlotinib Impurity 9 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: N-(6,7-bis(2-methoxyethoxy)quinazolin-4-yl)-N-(3-cyanophenyl)acetamide. Grades: > 95%. Molecular formula: C24H25N3O5. Mole weight: 435.48. | |
| Erlotinib Impurity 9 | Erlotinib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol. CAS No. 183321-86-0. Molecular Formula: C21H21N3O4. Mole Weight: 379.15. Catalog: APB183321860. | |
| Erlotinib Impurity C | Erlotinib Impurity C. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-(1-chlorovinyl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C22H25Cl2N3O4. Mole Weight: 466.36. Catalog: APB05336. | |
| Erlotinib Impurity E | Erlotinib Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(3-ethynylphenyl)-7-methoxy-6-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. Molecular Formula: C20H20ClN3O3. Mole Weight: 385.84. Catalog: APB05340. | |
| Erlotinib Impurity F | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: Erlotinib-3-vinyl Hydrochloride; 6,7-Bis(2-methoxyethoxy)-N-(3-vinylphenyl)quinazolin-4-amine Hydrochloride; N-(3-Ethenylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Hydrochloride. Grades: > 95%. CAS No. 1624294-38-7. Molecular formula: C22H25N3O4. Mole weight: 395.46. | |
| Erlotinib mesylate | Erlotinib is an EGFR inhibitor. The drug follows Iressa (gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. Synonyms: Tarceva; CP-358774; CP 358774; CP358774; OSI-774; OSI 774; OSI774; NSC 718781; NSC718781; NSC-718781; R 1415; R1415; R-1415. Grades: >98%. CAS No. 248594-19-6. Molecular formula: C23H27N3O7S. Mole weight: 489.54. | |
| Erlotinib metabolite M11 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 2-[[4-[(3-Ethynylphenyl)amino]-6-(2-methoxyethoxy)-7-quinazolinyl]oxy]acetic Acid. Grades: > 95%. CAS No. 882172-60-3. Molecular formula: C21H19N3O5. Mole weight: 393.40. | |
| Erlotinib metabolite M12 | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-hydroxyethoxy)quinazoline; 2-(4-(3-Ethynylanilino)-7-(2-hydroxyethoxy)quinazolin-6-yl)oxyethanol; 2-[4-(3-ethynylanilino)-7-(2-hydroxyethoxy)quinazolin-6-yl]oxyethanol. CAS No. 183321-84-8. Molecular formula: C20H19N3O4. Mole weight: 365.389. | |
| Erlotinib O-Desmethyl Metabolite Isomer | A metabolite of Erlotinib. Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity. Synonyms: Erlotinib 7-O-Desmethyl Metabolite; 2-[[4-[(3-Ethynylphenyl)amino]-6-(2-methoxyethoxy)-7-quinazolinyl] oxy]ethanol. Grades: > 95%. CAS No. 183320-29-8. Molecular formula: C21H21N3O4. Mole weight: 379.42. | |
| Erlotinib O-Desmethyl Metabolite Isomer (M13) | Erlotinib O-Desmethyl Metabolite Isomer (M13). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2-((4-((3-ethynylphenyl)amino)-6-(2-methoxyethoxy)quinazolin-7-yl)oxy)ethanol. CAS No. 183320-29-8. Molecular Formula: C21H21N3O4. Mole Weight: 379.41. Catalog: APB183320298. | |
| Erlotinib O-Desmethyl Metabolite Isomer (M14) HCl | OSI-420 (CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells. Uses: For research used only. Synonyms: OSI420; OSI-420; OSI 420; CP473420; CP-473420; CP 473420; Desmethyl Erlotinib. Grades: > 95%. CAS No. 183320-51-6. Molecular formula: C21H22ClN3O4. Mole weight: 415.874. | |
| Erlotinib (Standard) | Erlotinib (Standard) is the analytical standard of Erlotinib. This product is intended for research and analytical applications. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC 50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC 50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer [1]. Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 183321-74-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50896R. |  |
| ERO1 Inhibitor I, Erodoxin (Endoplasmic Reticulum Oxidase 1 Inhibitor, 1-Bromo-5-methoxy-2,4-dinitrobenzene) | A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1a (IC50=400uM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C?H?BrN?O?, Molecular Weight: 277. US Biological Life Sciences. |  Worldwide |
| ERO1 Inhibitor II, EN460 | A cell-permeable thiol reactive enone (EN) compound that selectively interacts with the active-site cysteine of reduced, active form of ERO1alpha and inhibits its activity (IC50 = 1.9uM). Also prevents ERO1 re-oxidation both in vitro and in mouse embryonic fibroblasts. Activates the unfolded protein response and protects ER-stressed 293T cells. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. Can inhibit ERO1alpha even in the presence of an excess amount of competing thiols. EN460 binding to ERO1alpha is shown to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme. Its inhibitory action appears to be irreversible, however addition of FAD and tris (hydroxypropyl) phosphine can restore some enzyme activity. Group: Biochemicals. Alternative Names: (Z)-2-Chloro-5-(4,5-dihydro-5-oxo-4-((5-phenyl-2-furanyl)methylene)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzoic Acid, (Z)-2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic Acid. Grades: Highly Purified. CAS No. 496807-64-8. Pack Sizes: 25mg. Molecular Formula: C??H??ClF?N?O?, Molecular Weight: 460.8. US Biological Life Sciences. | Worldwide |
| ErSO | ErSO is a selective anticipatory unfolded protein response ( a-UPR ) activator. ErSO acts through ERα to elicit strong and sustained cytotoxic activation of the a-UPR. ErSO can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2407860-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132247. | |
| Ersodetug | Ersodetug is an anti- INSR (insulin receptor) human IgG2 κ monoclonal antibody [1]. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control (HY-P99002). Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2410976-61-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990712. | |
| Ertapenem | Ertapenem. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R,5S,6S)-3-(((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid. CAS No. 153832-46-3. Molecular Formula: C22H25N3O7S. Mole Weight: 475.14. Catalog: APB153832463. | |
| Ertapenem | Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases. Ertapenem has been shown to be active against most isolates of the following microorganisms in vitro and in clinical infections. Synonyms: (1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3-carboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethyl-4-methyl-7-oxo-, (4R,5S,6S)-; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-((5-(((3-carboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-, (4R-(3(3S*, 5S*), 4α, 5β, 6β(R*)))-. Grades: 95%. CAS No. 153832-46-3. Molecular formula: C22H25N3O7S. Mole weight: 475.52. | |
| Ertapenem Acetic Acid Adduct Impurity | An impurity of Ertapenem. Ertapenem is a carbapenem antibiotic. Synonyms: (4R,5S)-1-acetyl-5-((1S,2R)-1-carboxy-2-hydroxypropyl)-3-(((3R,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)thio)-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid. Grades: > 95%. Molecular formula: C24H27N3O9S. Mole weight: 533.56. | |
| Ertapenem Dimer ? | Ertapenem Dimer ?. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R,5S,6S)-3-(((3S,5S)-1-((2S,3R)-2-((1S,2R)-1-carboxy-2-hydroxypropyl)-4-(((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)thio)-3-methyl-3,4-dihydro-2H-pyrrole-5-carbonyl)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid. Molecular Formula: C44H50N6O14S2. Mole Weight: 951.03. Catalog: APB05881. | |
| Ertapenem Dimer ? | Ertapenem Dimer ?. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R, 5S, 6S) -3- ( ( (3R, 5R) -5- ( (3- ( ( ( (2R) -1-carboxy-1- ( (3S) -5-carboxy-4- ( ( (3R, 5R) -5- ( (3-carboxyphenyl) carbamoyl) pyrrolidin-3-yl) thio) -3-methyl-3, 4-dihydro-2H-pyrrol-2-yl) propan-2-yl) oxy) carbonyl) phenyl) carbamoyl) pyrrolidin-3-yl) thio) -6- ( (R) -1-hydroxyethyl) -4-methyl-7-oxo-1-azabicyclo[3. 2. 0]hept-2-ene-2-carboxylic acid. Molecular Formula: C44H50N6O14S2. Mole Weight: 951.03. Catalog: APB01884. | |
| Ertapenem Dimer ? | Ertapenem Dimer ?. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R,5S,6S)-3-(((3S,5S)-5-((3-((2S,4S)-4-(((4R,5S)-2-carboxy-5-((1S,2R)-1-carboxy-2-hydroxypropyl)-4-methyl-4,5-dihydro-1H-pyrrol-3-yl)thio)-2-((3-carboxyphenyl)carbamoyl)pyrrolidine-1-carbonyl)phenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid. Molecular Formula: C44H50N6O14S2. Mole Weight: 951.03. Catalog: APB05882. | |
| Ertapenem Dimer 1 | Ertapenem Dimer 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4R,5S,6S)-3-(((3S,5S)-1-((2S,3R)-2-((2S,3R)-5-carboxy-4-(((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)thio)-3-methyl-2,3-dihydro-1H-pyrrol-2-yl)-3-hydroxybutanoyl)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid. CAS No. 402955-34-4. Molecular Formula: C44H50N6O14S2. Mole Weight: 951.03. Catalog: APB402955344. | |
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