A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Geldanamycin binds specifically to heat shock protein HSP90; inhibits protein maturation. Group: Biochemicals. Alternative Names: 9, 13-Dihydroxy-8, 14, 19-trimethoxy-4, 10, 12, 16-tetramethyl-2-azabicyclo[16. 3. 1]docosa-4, 6, 10, 18, 21-pentaene-3, 20, 22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518; BRN1633093. Grades: Highly Purified. CAS No. 30562-34-6. Pack Sizes: 1mg, 25mg, 100mg, 250mg, 1g. US Biological Life Sciences.
Worldwide
Gel Dye
Gel Dye. Gel dye is a sensitive, stable and relatively safe fluorescent nucleic acid dye designed to replace the highly toxic ethidium bromide (etbr) for staining dsdna, ssdna or rna in agarose gels or polyacrylamide gels. the sensitivity of gel dye is much higher than eb, and destaining is not required. gel ye and eb have virtually the same spectral properties. Group: Markers & Ladders. Storage: Store at -20 ?. Cat No: MK-2003.
Gellan gum
Gellan gum is a water-soluble polysaccharide produced by the bacterium Sphingomonas elodea. Gellan gum is composed of repeating units of tetrasaccharide, specifically glucose, rhamnose, and glucuronic acid. It is widely used as a gelling agent, thickener, and stabilizer in various food, pharmaceutical, and industrial applications due to its ability to form gels and its versatility in different conditions. Synonyms: Bistop MN-HM; Gel-Gro; Gellan; Gelrite; Gelrite gellan gum; Gelup K-S (F); Gelzan; Gelzan CM; Grindsted Gellan DAI 90; Kelcogel; Kelcogel 700; Kelcogel AF; Kelcogel AFT; Kelcogel CG; Kelcogel CG-LA; Kelcogel DGA; Kelcogel HF-B; Kelcogel Hi-pHive; Kelcogel HMB; Kelcogel HP-T; Kelcogel HT-P; Kelcogel hydriodide-pHive; Kelcogel PS; LT 100 (stabilizer); Neosoft J; Neosoft J 40; Newgelin LG-10; OMY; Phytagel; PS 60; Roeper 700f; Takaragen FE 01; TayaGel. CAS No. 71010-52-1.
Gellan gum
Gellan gum. Alternative Names: Gum, gellan. CAS No. 71010-52-1. Product ID: ACM71010521-9. Alfa Chemistry - ISO 9001:32057 Certified.
Gellan Gum
Gellan Gum. Group: Food ingredients. Pack Sizes: 25 Kg Drums.
Gellan Gum
Gellan Gum. CAS No. 71010-52-1.
Gellan Gum
Gellan Gum. CAS No. 71010-52-1. Cenik is your partner of choice for specialised chemicals. We don't just provide products - we supply solutions to your technical and regulatory specifications.
Gellan gum, for cell culture
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Agar substitute gelling agent, for cell culture. CAS No. 71010-52-1. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-125870.
gellan lyase
The enzyme is highly specific to gellan, especially deacetylated gellan. Group: Enzymes. Enzyme Commission Number: EC 4.2.2.25. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5101; gellan lyase; EC 4.2.2.25. Cat No: EXWM-5101.
The enzyme releases 4-deoxy-4(5)-unsaturated D-glucuronic acid from oligosaccharides produced by polysaccharide lyases, e.g. the tetrasaccharide β-D-4-deoxy-Δ4-GlcAp-(1?4)-β-D-Glcp-(1?4)-α-L-Rhap-(1?3)-β-D-Glcp produced by EC 4.2.2.25, gellan lyase. The enzyme can also hydrolyse unsaturated chondroitin and hyaluronate disaccharides (β-D-4-deoxy-Δ4-GlcAp-(1?3)-β-D-GalNAc, β-D-4-deoxy-Δ4-GlcAp-(1?3)-β-D-GalNAc6S, β-D-4-deoxy-Δ4-GlcAp2S-(1?3)-β-D-GalNAc, β-D-4-deoxy-Δ4-GlcAp-(1?3)-β-D-GlcNAc), preferring the unsulfated disaccharides to the sulfated disaccharides. Group: Enzymes. Synonyms: UGL (ambiguous); unsaturated glucuronyl hydrolase (ambiguous). Enzyme Commission Number: EC 3.2.1.179. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3862; gellan tetrasaccharide unsaturated glucuronyl hydrolase; EC 3.2.1.179; UGL (ambiguous); unsaturated glucuronyl hydrolase (ambiguous). Cat No: EXWM-3862.
GelMA, 30% methacrylation, Green Fluorescent
GelMA, 30% methacrylation, Green Fluorescent. Uses: For analytical and research use. Alternative Names: Gelatin Methacryloyl, 30% methacrylation, Green Fluorescent. Catalog: APB12504.
GelMA, 30% methacrylation, Red Fluorescent
GelMA, 30% methacrylation, Red Fluorescent. Uses: For analytical and research use. Alternative Names: Gelatin Methacryloyl, 30% methacrylation, Red Fluorescent. Catalog: APB12505.
GelMA, 60% methacrylation
GelMA (Gelatin Methacryloyl), 60% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gelatin Methacryloyl, 60% methacrylation. CAS No. 2280018-77-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W763582A.
GelMA, 60% methacrylation, Green Fluorescent
GelMA, 60% methacrylation, Green Fluorescent. Uses: For analytical and research use. Alternative Names: Gelatin Methacryloyl, 60% methacrylation, Green Fluorescent. Catalog: APB12498.
GelMA, 60% methacrylation, red fluorescent
GelMA, 60% methacrylation, red fluorescent. Uses: For analytical and research use. Alternative Names: Gelatin Methacryloyl, 60% methacrylation, red fluorescent. Catalog: APB12492.
GelMA, 90% methacrylation
GelMA (Gelatin Methacryloyl), 90% methacrylation, is a derivative obtained by the reaction of Methacrylic anhydride (MA) (HY-W017330) and gelatin. GelMA exhibits excellent biocompatibility, biodegradability, and moldability. GelMA can be photocrosslinked into hydrogels and can be used for research in regeneration of tissues, such as skin, tendon, bone, cartilage, blood vessel, and cardiovascular system. GelMA hydrogel also can be used for research on drug delivery, organ-on-a-chip, and biosensing[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gelatin Methacryloyl, 90% methacrylation. CAS No. 2280018-77-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W763582B.
GelMA, 90% methacrylation, Green Fluorescent
GelMA, 90% methacrylation, Green Fluorescent. Uses: For analytical and research use. Alternative Names: Gelatin Methacryloyl, 90% methacrylation, Green Fluorescent. Catalog: APB12491.
Gelomulide A
Gelomulide A is isolated from Suregada. Synonyms: (3β,5β,9β,10α,12β,14β)-16-Oxo-8,14:12,16-diepoxyabiet-13(15)-en-3-yl acetate. Grade: 98%. CAS No. 122537-59-1. Molecular formula: C22H30O5. Mole weight: 374.471.
Gelomulide B
Gelomulide B is a diterpenoid found in Suregada multiflora. Synonyms: (3S,4aS,6aS,7aR,10aS,11aS,11bR,11cR)-4,4,8,11c-tetramethyl-9-oxo-1,2,3,4,4a,5,6,7a,9,11a,11b,11c-dodecahydrobis(oxireno)[2',3':1,10a; 2'',3'':3,4]phenanthro[3,2-b]furan-3-yl acetate. Grade: 97.5%. CAS No. 122537-60-4. Molecular formula: C22H28O6. Mole weight: 388.454.
Gelomulide N
Gelomulide N also called 1alpha,3beta-Diacetoxy-8beta,14beta-epoxy-ent-abiet-13(15)-en-16,12-olide, is a natural diterpenoid compound. Synonyms: 1alpha,3beta-Diacetoxy-8beta,14beta-epoxy-ent-abiet-13(15)-en-16,12-olide; 1-epi-Gelomulide O. Grade: >97%. CAS No. 1005212-02-1. Molecular formula: C24H32O7. Mole weight: 432.51.
Gelsemine
Gelsemine. Group: Biochemicals. Grades: Plant Grade. CAS No. 509-15-9. Pack Sizes: 10mg. Molecular Formula: C20H22N2O2, Molecular Weight: 322.4. US Biological Life Sciences.
Worldwide
Gelsemine
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive effects. Uses: Scientific research. Category: Natural products. CAS No. 509-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0388.
Gelsevirine, isolated from the herbs of Gelsemium elegans, could be developed as the treatment of anxiety-related disorders in human patients. Their anxiolytic mechanism may be involved in the agonist action of glycine receptor in the brain. Uses: Anxiolytic. Synonyms: Gelsemine, 1-methoxy-; 1-Methoxygelsemine. Grade: >98%. CAS No. 38990-03-3. Molecular formula: C21H24N2O3. Mole weight: 352.4.
Gelucire 44/14
Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery. Uses: Scientific research. Category: Signaling pathways. CAS No. 121548-04-7. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-Y1892.
GEM144
GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2487526-28-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143411.
GEM-5
GEM-5, a gemcitabine-based conjugate incorporating a HIF-1α inhibitor (YC-1) (IC 50 =30 nM), notably suppresses HIF-1α expression while enhancing tumor suppressor p53 expression. It induces apoptosis in A2780 cells and curbs tumor growth. Category: Active pharmaceutical ingredients. CAS No. 2233543-49-0. Product ID: API2233543490. Molecular formula: C32H29F2N5O8. Mole weight: 649.6.
Gem-C12
Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 849139-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-185323.
Gemcabene
Gemcabene is an orally available lipid-lowering small molecule designed to target known lipid metabolic pathways, as an adjunctive therapy to reduce LDL-C, hsCRP and triglycerides (TGs). Currentl, Gemcabene is under Phase-II clinical trials in Hypertriglyceridaemia in USA. Synonyms: 6-(5-carboxy-5-methyl-hexoxy)-2,2-dimethyl-hexanoic acid; gemcabene; 6,6'-oxybis(2,2-dimethylhexanoic acid); PD72953; PD 72953; PD-72953. Grade: >98%. CAS No. 183293-82-5. Molecular formula: C16H30O5. Mole weight: 302.41.
Gemcadiol
Gemcadiol is a new antilipemic drug with lipid-regulating properties. Uses: Antilipemic. Synonyms: CI-720; CI 720; CI720; 2,2,9,9-Tetramethyl-1,10-decanediol. Grade: ≥98%. CAS No. 35449-36-6. Molecular formula: C14H30O2. Mole weight: 230.389.
Gemcitabine
Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis. Group: Inhibitors. Alternative Names: LY-188011, NSC 613327. CAS No. 95058-81-4. Pack Sizes: 50mg. Product ID: S1714. Formula: C9H11F2N3O4. Smiles: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F. Storage Conditions: powder, 4°C,3 years (in the dark) ; in solvent, -80°C,1 year (in the dark).
United States; Europe
Gemcitabine
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis. Category: Active pharmaceutical ingredients. CAS No. 95058-81-4. Product ID: API95058814. Molecular formula: C9H11F2N3O4. Mole weight: 263.2.
Gemcitabine
Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011. CAS No. 95058-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-17026.
Gemcitabine
Gemcitabine is a nucleoside analogue used in chemotherapy. It treats cancers including testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer and bladder cancer. Synonyms: 2'-Deoxy-2',2'-difluorocytidine; 2'-Deoxy-2',2'-difluoro-D-cytidine; 2',2'-Difluoro-2'-deoxycytidine; 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 2',2'-Difluorodeoxycytidine; DDFC; DFdC; Folfugem; GemLip; Gemcel; NSC 613327; Gemzar. Grade: ≥95%. CAS No. 95058-81-4. Molecular formula: C9H11F2N3O4. Mole weight: 263.20.
Gemcitabine-13C,15N2
antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011-13C,15N2. CAS No. 1233921-74-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-17026S.
Gemcitabine-13C,15N2 hydrochloride
Gemcitabine-13C,15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride[1]. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011-13C,15N2 hydrochloride. CAS No. 2757566-59-7. Pack Sizes: 500 μg. Product ID: HY-B0003S.
Gemcitabine-[13C,15N2] Hydrochloride
Gemcitabine-[13C,15N2] Hydrochloride is the labelled analogue of Gemcitabine. Gemcitabine is an antitumor drug used for the treatment of multiple cancers. Synonyms: Gemcitabine-13C,15N2 Hydrochloride; 2'-Deoxy-2',2'-difluoro-cytidine-2-13C-1,3-15N2 monohydrochloride; 2'-Deoxy-2',2'-difluorocytidine-13C,15N2 Hydrochloride; 4-Amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one-2-13C-1,3-15N2 hydrochloride. Grade: 95% by HPLC; 95% atom 13C; 95% atom 15N. CAS No. 2757566-59-7. Molecular formula: C8[13C]H11F2N[15N]2O4.HCl. Mole weight: 302.64.
Labeled Gemcitabine, an antineoplastic. Group: Biochemicals. Alternative Names: 2-Deoxy-2,2-difluorocytidine-13C,15N2 Hydrochloride. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Gemcitabine-5'-diphosphate
A diphosphorylated derivative of Gemcitabine and has been found to exhibit potent activities as an inhibitor of ribonucleotide reductases (RNRs). Synonyms: 2'-deoxy-2',2'-difluorocytidine 5'-(trihydrogen diphosphate). Grade: ≥ 95 % by HPLC. CAS No. 116371-66-5. Molecular formula: C9H13F2N3O10P2. Mole weight: 423.16.
Gemcitabine 5'-elaidate
Gemcitabine 5'-elaidate. Group: Biochemicals. Alternative Names: (E)-((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate; 2'-Deoxy-2',2'-difluorocytidine 5'-(9E)-9-octadecenoate; CP-4126; LVT derivative of Gemcitabine; CO-101. Grades: Highly Purified. CAS No. 210829-30-4. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C27H43F2N3O5. US Biological Life Sciences.
Worldwide
Gemcitabine-5'-triphosphate
A triphosphorylated derivative of Gemcitabine and has been found to exhibit potent activities as a cytotoxic agent and induce apoptosis. Synonyms: 2',2'-Difluorocytidine-5'-triphosphate. Grade: ≥ 95 % by HPLC. Molecular formula: C9H14N3O13P3F2. Mole weight: 503.14.
Gemcitabine alpha-anomer
Gemcitabine alpha-anomer is an anomer of Gemcitabine. Gemcitabine is a nucleoside analog used in chemotherapy to treat cancers including testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer, and bladder cancer. Synonyms: Gemcitabine EP Impurity B; 4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythropentofuranosyl)pyrimidin-2(1H)-one; Gemcitabine α-anomer; 4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone; Gemcitabine Impurity B; 1'-Epi Gemcitabine; 4-Amino-1-((2S,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 1-(2,2-Difluoro-2-deoxy-α-D-ribofuranosyl)cytosine; α-Gemcitabine; Gemcitabine hydrochloride EP Impurity B. Grade: ≥95%. CAS No. 95058-85-8. Molecular formula: C9H11F2N3O4. Mole weight: 263.20.
Gemcitabine (alpha-Isomer) Hydrochloride
Gemcitabine (alpha-Isomer) Hydrochloride is an α-Anomer of Gemcitabine. Gemcitabine is a nucleoside analogue used in chemotherapy. It treats cancers including testicular cancer, breast cancer, ovarian cancer, non-small cell lung cancer, pancreatic cancer and bladder cancer. Synonyms: 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2,2-difluoro-α-D-erythro-pentofuranosyl)-, hydrochloride (1:1); Gemcitabine EP Impurity B hydrochloride; 4-Amino-1-(2-deoxy-2,2-difluoro-α-D-erythropentofuranosyl)pyrimidin-2(1H)-one hydrochloride; Gemcitabine α-anomer hydrochloride; Gemcitabine Impurity B hydrochloride; 1'-Epi Gemcitabine hydrochloride; 1-(2,2-Difluoro-2-deoxy-α-D-ribofuranosyl)cytosine hydrochloride; α-Gemcitabine hydrochloride. Grade: >95%. CAS No. 122111-05-1. Molecular formula: C9H12F2N3O4Cl. Mole weight: 299.65.
Gemcitabine Diphosphate Ammonium Salt
Gemcitabine Diphosphate is a phosphorylated metabolite of Gemcitabine, an antineoplastic agent. Group: Biochemicals. Alternative Names: 2-Deoxy-2,2-difluorocytidine 5-(Trihydrogen Diphosphate) Triethylamine Salt; Gemcitabine 5-Diphosphate Triethylamine Salt. Grades: Highly Purified. CAS No. free acid: 116371-66-5. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Gemcitabine Diphosphate Choline
Gemcitabine derivative. An antineoplastic agent. Group: Biochemicals. Alternative Names: Gemcitabine 5-Diphosphate Choline. Grades: Highly Purified. CAS No. 1643126-46-8. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Gemcitabine Diphosphate Choline
Gemcitabine derivative. An antineoplastic agent. Synonyms: Gemcitabine 5'-Diphosphate Choline. Grade: 95%. CAS No. 1643126-46-8. Molecular formula: C14H24F2N4O10P2. Mole weight: 508.31.
Gemcitabine Diphosphate Triethylamine Salt
Gemcitabine Diphosphate is a Gemcitabine phosphorylated metabolite, an antineoplastic agent. Synonyms: 2'-Deoxy-2',2'-difluorocytidine 5'-(Trihydrogen Diphosphate) Triethylamine Salt; Gemcitabine 5'-Diphosphate Triethylamine Salt. Grade: 90%. Molecular formula: C27H58F2N6O10P2. Mole weight: 726.73.
Gemcitabine elaidate
Gemcitabine elaidate (also known as CO-101; CP-4126) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Synonyms: CO-101; CO101; CO 101; CP-4126; CP4126; CP 4126. CAS No. 210829-30-4. Molecular formula: C27H43F2N3O5. Mole weight: 527.654.
Gemcitabine elaidate
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. Category: Active pharmaceutical ingredients. Synonyms: Gemcitabine 5'-elaidate, Gemcitabine (elaidate), CO-101, CP-4126. CAS No. 210829-30-4. Product ID: API210829304. Molecular formula: C27H43F2N3O5. Mole weight: 527.64.
Gemcitabine elaidate hydrochloride
Gemcitabine elaidate (CP-4126) hydrochloride is a lipophilic pro-drug of Gemcitabine, converted to Gemcitabine by esterases for phosphorylation. Category: Active pharmaceutical ingredients. Synonyms: Gemcitabine elaidate hydrochloride(210829-30-4(free base)), Gemcitabine 5'-elaidate hydrochloride, CP-4126 hydrochloride, CO-101 hydrochloride. CAS No. 2918768-08-6. Product ID: API2918768086. Molecular formula: C27H44ClF2N3O5. Mole weight: 564.11.
Gemcitabine elaidate hydrochloride
Gemcitabine elaidate is a lipophilic prodrug form of the nucleoside analog gemcitabine that contains an elaidic acid moiety. Gemcitabine elaidate inhibits growth of gemcitabine-sensitive L1210/L5, BCLO, and A2780 cells (IC50s = 0.0033, 0.0042, and 0.0025 μM, respectively) but not cytarabine-resistant L4A6 and Bara-C cells (IC50s = 16 and 13 μM, respectively) or gemcitabine-resistant AG6000 cells (IC50 = 91 μM). Synonyms: CO-101 hydrochloride; CP-4126 hydrochloride; Gemcitabine 5'-elaidate hydrochloride. Grade: ≥97%. CAS No. 2918768-08-6. Molecular formula: C27H44ClF2N3O5. Mole weight: 564.11.
Gemcitabine EP Impurity B
Gemcitabine EP Impurity B. Uses: For analytical and research use. CAS No. 122111-05-1. Molecular formula: C9H11F2N3O4·ClH. Mole weight: 299.66. Catalog: APB122111051.
Gemcitabine hydrochloride
Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011 hydrochloride. CAS No. 122111-03-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0003.
Gemcitabine hydrochloride
Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Uses: Antimetabolites, antineoplastic. Synonyms: Gemzar; Gemcitabine HCl; LY188011 hydrochloride. Grade: >98%. CAS No. 122111-03-9. Molecular formula: C9H11F2N3O4.HCI. Mole weight: 299.66.
Gemcitabine hydrochloride
Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis. Category: Active pharmaceutical ingredients. Synonyms: Gemcitabine HCl, Gemzar, LY 188011 hydrochloride. CAS No. 122111-03-9. Product ID: API122111039. Molecular formula: C9H11F2N3O4·HCl. Mole weight: 299.66.
Gemcitabine hydrochloride
5g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C9H11F2N3O4 · HCl. CAS No. 122111-03-9. Prepack ID 56199790-5g. Molecular Weight 299.66. See USA prepack pricing.
Gemcitabine Hydrochloride
Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy. Group: Inhibitors. Alternative Names: NSC 613327 HCl,LY-188011 HCl. CAS No. 122111-03-9. Pack Sizes: 25mg. Product ID: S1149. Formula: C9H11F2N3O4.HCI. Smiles: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl. Storage Conditions: 2 years -80 in solvent.
Gemcitabine is a nucleoside analog of deoxycytidine used as chemotherapy to treat patients with various types of cancer. After passage through the cell membrane via nucleoside transporters, gemcitabine undergoes complex intracellular conversion to gemcitabine diphosphate (dFdCDP) and triphosphate (dFdCTP). dFdCTP inhibits DNA polymerase by competing with deoxycytidine triphosphate (dCTP). dFdCDP inhibits ribonucleoside reductase and DNA synthesis by causing depletion of deoxyribonucleotide pools, and thus potentiating the effects of dFdCTP. Gemcitabine can be inactivated to 2,2'-difluorodeoxyuridine, mainly by deoxycytidine deaminase. Also, 5'-nucleotidase catalyses the conversion of nucleotides to nucleosides and inhibits nucleoside kinases. Group: Biochemicals. Alternative Names: 2-Deoxy-2,2-difluorocytidine Hydrochloride, dFdC, dFdCyd. Grades: Highly Purified. CAS No. 122111-03-9. Pack Sizes: 100mg, 500mg, 1g. US Biological Life Sciences.
Worldwide
Gemcitabine hydrochloride EP impurity A/Lamivudine EP impurity E
Gemcitabine hydrochloride EP impurity A/Lamivudine EP impurity E. Uses: For analytical and research use. CAS No. 71-30-7. Molecular formula: C4H5N3O. Mole weight: 111.1. Catalog: APB71307.
Gemcitabine hydrochloride (Standard)
Gemcitabine (hydrochloride) (Standard) is the analytical standard of Gemcitabine (hydrochloride). This product is intended for research and analytical applications. Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 188011 hydrochloride (Standard). CAS No. 122111-03-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0003R.
Gemcitabine Impurity 1. Uses: For analytical and research use. Alternative Names: ((2R,3R)-3-(benzoyloxy)-4,4-difluoro-5-oxotetrahydrofuran-2-yl)methyl benzoate. CAS No. 122111-01-7. Molecular formula: C19H14F2O6. Mole weight: 376.31. Catalog: APB122111017.
Gemcitabine Impurity 13
Gemcitabine Impurity 13. Uses: For analytical and research use. Alternative Names: 1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. CAS No. 114248-23-6. Molecular formula: C9H10F2N2O5. Mole weight: 264.18. Catalog: APB114248236.
Gemcitabine Impurity 15
Gemcitabine Impurity 15. Uses: For analytical and research use. Alternative Names: ((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl benzoate. CAS No. 2174019-90-8. Molecular formula: C16H15F2N3O5. Mole weight: 367.3. Catalog: APB2174019908.
Gemcitabine Impurity 2. Uses: For analytical and research use. Molecular formula: C28H32ClNO10. Mole weight: 578.01. Catalog: APB10503.
Gemcitabine Impurity 2
Gemcitabine Impurity 2. Uses: For analytical and research use. Alternative Names: ((2R,3R)-3-(benzoyloxy)-4,4-difluoro-5-hydroxytetrahydrofuran-2-yl)methyl benzoate. CAS No. 143157-22-6. Molecular formula: C19H16F2O6. Mole weight: 378.32. Catalog: APB143157226.
Gemcitabine Impurity 3
Gemcitabine Impurity 3. Uses: For analytical and research use. CAS No. 153381-14-7. Molecular formula: C9H10F2N2O5. Mole weight: 264.18. Catalog: APB153381147.