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Gedatolisib (Standard) is the analytical standard of Gedatolisib. This product is intended for research and analytical applications. Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively[1]. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197160-78-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10681R.
Gedivumab
Gedivumab (MHAA4549A; RG7745) is a human monoclonal antibody that targets influenza A virus (IAV) with high specificity and binds to the highly conserved stem region of the IAV haemagglutinin protein, thereby preventing haemagglutinin maturation and blocking haemagglutinin-mediated membrane fusion in the intranucleosome. Gedivumab can be used in IAV infection disease studies[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MHAA4549A; RG7745. CAS No. 1807954-17-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99637.
Gedunin is a naturally occurring Hsp90 inhibitor. Induces Hsp90-dependent client protein degradation and displays antiproliferative activity in vitro (IC50 values are 3.22, 8.84 and 16.8 μM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively). It also exhibits antimalarial activity against P. falciparum (IC50 values are 0.14 and 3.1 μM in parasite development and [3H]-hypoxanthine uptake assays respectively). Grade: >98%. CAS No. 2753-30-2. Molecular formula: C28H34O7. Mole weight: 482.57.
Gefapixant
Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. It is under a clinical trial for the treatment of chronic cough. Synonyms: AF-219; MK-7264. CAS No. 1015787-98-0. Molecular formula: C14H19N5O4S. Mole weight: 353.4.
Gefapixant
Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-7264; AF-219. CAS No. 1015787-98-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101588.
Gefapixant citrate
Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-7264 citrate; AF-219 citrate. CAS No. 2310299-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101588A.
Gefapixant Impurity 1
Gefapixant Impurity 1. Uses: For analytical and research use. CAS No. 865304-71-8. Molecular formula: C14H18N4O2. Mole weight: 274.32. Catalog: APB865304718.
Gefapixant Impurity 10
Gefapixant Impurity 10. Uses: For analytical and research use. Molecular formula: C15H21N5O. Mole weight: 287.37. Catalog: APB12141.
Gefapixant Impurity 11
Gefapixant Impurity 11. Uses: For analytical and research use. Molecular formula: C14H20N6O4S. Mole weight: 368.41. Catalog: APB12142.
Gefapixant Impurity 12
Gefapixant Impurity 12. Uses: For analytical and research use. Molecular formula: C15H20N4O5S. Mole weight: 368.41. Catalog: APB12143.
Gefapixant Impurity 13
Gefapixant Impurity 13. Uses: For analytical and research use. Molecular formula: C17H24N4O5S. Mole weight: 396.46. Catalog: APB12144.
Gefapixant Impurity 2
Gefapixant Impurity 2. Uses: For analytical and research use. CAS No. 2413718-92-8. Molecular formula: C14H18N4O4S. Mole weight: 338.38. Catalog: APB2413718928.
Gefapixant Impurity 3
Gefapixant Impurity 3. Uses: For analytical and research use. Molecular formula: C13H18N6O3S. Mole weight: 338.39. Catalog: APB12137.
Gefapixant Impurity 4
Gefapixant Impurity 4. Uses: For analytical and research use. Molecular formula: C13H16BrN5O3S. Mole weight: 402.27. Catalog: APB12138.
Gefapixant Impurity 5
Gefapixant Impurity 5. Uses: For analytical and research use. Molecular formula: C13H17N5O3S. Mole weight: 323.37. Catalog: APB12136.
Gefapixant Impurity 6
Gefapixant Impurity 6. Uses: For analytical and research use. Molecular formula: C15H20N6O2. Mole weight: 316.37. Catalog: APB12139.
Gefapixant Impurity 7
Gefapixant Impurity 7. Uses: For analytical and research use. CAS No. 2527107-23-7. Molecular formula: C20H25N5O3. Mole weight: 383.45. Catalog: APB2527107237.
Gefapixant Impurity 8
Gefapixant Impurity 8. Uses: For analytical and research use. CAS No. 2527107-24-8. Molecular formula: C20H25N5O3. Mole weight: 383.45. Catalog: APB2527107248.
Gefapixant Impurity 9
Gefapixant Impurity 9. Uses: For analytical and research use. Molecular formula: C23H28N4O3. Mole weight: 408.5. Catalog: APB12140.
Gefarnate
Gefarnate is a drug used for the treatment of gastritis and gastric ulcer, in vivo, the instillation of gefarnate reduced corneal epithelial damage from desiccation in a dose-dependent fashion. Besides Gefarnate has been proposed for use in the treatment of dry eye syndrome. Synonyms: [(2E)-3,7-dimethylocta-2,6-dienyl] (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate; Farnesylacetate, Geranyl; Gefarnate; Gefarnil; Gepharnate; Geranyl Farnesylacetate; Ulco. CAS No. 51-77-4. Molecular formula: C27H44O2. Mole weight: 400.64.
Gefarnate
Gefarnate. Group: Biochemicals. Alternative Names: Geranyl farnesylacetate. Grades: Highly Purified. CAS No. 51-77-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C27H44O2. US Biological Life Sciences.
Worldwide
Gefitinib
Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer [1][2][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZD1839. CAS No. 184475-35-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-50895.
Gefitinib
100mg Pack Size. Group: Bioactive Small Molecules, Biochemicals, Research Organics & Inorganics. Formula: C22H24ClFN4O3. CAS No. 184475-35-2. Prepack ID 57220562-100mg. Molecular Weight 446.9. See USA prepack pricing.
Gefitinib
Gefitinib. Group: Biochemicals. Grades: Highly Purified. CAS No. 184475-35-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C22H24ClFN4O3. US Biological Life Sciences.
Worldwide
Gefitinib
Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell lung cancers. Gefitinib administration RESULTS in the development of the EGFR C797S resistance mutation. Category: Active pharmaceutical ingredients. CAS No. 184475-35-2. Product ID: API184475352. Molecular formula: C22H24ClFN4O3. Mole weight: 446.9.
Gefitinib
Gefitinib is an antineoplastic drug. Gefitinib effectively inhibits all tyrosine phosphorylation sites on EGFR in both the high and low EGFR-expressing cell lines including NR6, NR6M and NR6W cell lines. The phosphorylation sites Tyr1173 and Tyr992 are less sensitive requiring higher concentrations of Gefitinib for inhibition. Synonyms: ZD1839; ZD 1839; ZD-1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa; gefitinibum. Grade: >98%. CAS No. 184475-35-2. Molecular formula: C22H24ClFN4O3. Mole weight: 446.90.
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230821-27-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123921.
Gefitinib-d3 (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1173976-40-3. Pack Sizes: 1 mg. Product ID: HY-50895S2.
Gefitinib-d3
Labeled Gefitinib. Gefitinib is an antineoplastic. Group: Biochemicals. Alternative Names: N-(3-Chloro-4-fluorophenyl)-7-(methoxy-d3)-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; Iressa-d3; ZD 1839-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Gefitinib-[d3]
Gefitinib-[d3] is the labelled analogue of Gefitinib. Gefitinib is an EGFR inhibitor. It is used for the treatment of certain breast, lung and other cancers. Synonyms: Gefitinib D3; N-(3-Chloro-4-fluorophenyl)-7-(methoxy-d3)-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine. Grade: 98% by HPLC; 99% atom D. CAS No. 1173976-40-3. Molecular formula: C22H21D3ClFN4O3. Mole weight: 449.92.
Gefitinib-d6
Gefitinib-d6 is a deuterated compound of Gefitinib. Gefitinib has a CAS number of 184475-35-2. Gefitinib is an EGFR tyrosine kinase inhibitor and can inhibit Tyr1173, Tyr992, Tyr1173 and Tyr992 (IC50s: 37/37/26/57 nM). Category: Active pharmaceutical ingredients. CAS No. 1228664-49-0. Product ID: API1228664490. Molecular formula: C22H18D6ClFN4O3. Mole weight: 452.94.
Gefitinib-[d6]
One of the isotopic labelled form of Gefitinib, which could be used as an antineoplastic agent. Synonyms: Gefitinib-d6; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine-d6; Iressa-d6. CAS No. 1228664-49-0. Molecular formula: C22H18ClFN4O3D6. Mole weight: 452.95.
Gefitinib-d8ZD1839 D8, Gefitinib D8
Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8is a deuterium labeled Gefitinib. Category: Active pharmaceutical ingredients. CAS No. 857091-32-8. Product ID: API857091328. Molecular formula: C22H24ClFN4O3. Mole weight: 454.95.
Gefitinib Difluoro Impurity
Gefitinib Difluoro Impurity. Uses: For analytical and research use. CAS No. 184475-50-1. Molecular formula: C22H24F2N4O3. Mole weight: 430.46. Catalog: APB184475501.
Gefitinib dihydrochloride
Gefitinib dihydrochloride is a potent, selective, orally active EGFR tyrosine kinase inhibitor (IC50: 33 nM). Gefitinib dihydrochloride selectively inhibits EGF-stimulated tumor cell growth with an IC50 value of 54 nM and blocks EGFR autophosphorylation in EGF-stimulated tumor cells. Gefitinib dihydrochloride induces autophagy and apoptosis, and can be used in studies of cancer-related diseases such as lung and breast cancer. Category: Active pharmaceutical ingredients. CAS No. 184475-56-7. Product ID: API184475567. Molecular formula: C22H26Cl3FN4O3. Mole weight: 519.82.
Gefitinib EP Impurity A
An impurity of Gefitinib. Gefitinib is a first-generation EGFR tyrosine kinase inhibitor used primarily to treat non-small cell lung cancer (NSCLC) in patients with specific EGFR mutations. Synonyms: Gefitinib Impurity 12; 7-Methoxy-6-(3-morpholin-4-ylpropoxy)-1H-quinazolin-4-one; 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one; 7-Methoxy-6-[3-(4-morpholinyl)propoxy]-4(3H)-quinazolinone; 7-Methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one; 7-Methoxy-6-(3-morpholinopropoxy)quinazolin-4-one; 7-Methoxy-6-[3-(4-morpholinyl)propoxy]quinazolin-4(3H)-one. Grade: ≥95%. CAS No. 199327-61-2. Molecular formula: C16H21N3O4. Mole weight: 319.36.
Gefitinib EP Impurity B
An impurity of Gefitinib. Gefitinib is a first-generation EGFR tyrosine kinase inhibitor used primarily to treat non-small cell lung cancer (NSCLC) in patients with specific EGFR mutations. Synonyms: N-(4-Chloro-3-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine; N-(4-Chloro-3-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine; 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib; Gefitinib Imp. B (EP); Gefitinib Impurity B. Grade: ≥95%. CAS No. 1603814-04-5. Molecular formula: C22H24ClFN4O3. Mole weight: 446.90.
Gefitinib EP Impurity B
Gefitinib EP Impurity B. Uses: For analytical and research use. CAS No. 1603814-04-5. Molecular formula: C22H24ClFN4O3. Mole weight: 446.91. Catalog: APB1603814045.
Gefitinib hydrochloride
Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZD-1839 hydrochloride. CAS No. 184475-55-6. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-50895A.
Gefitinib hydrochloride
Gefitinib Hcl(ZD-1839 Hcl) is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. Synonyms: Iressa hydrochloride; ZD 1839 hydrochloride; ZD-1839 hydrochloride; ZD1839 hydrochloride. Grade: >98%. CAS No. 184475-55-6. Molecular formula: C22H25Cl2FN4O3. Mole weight: 483.36.
Gefitinib impurity 1
Gefitinib impurity 1. Uses: For analytical and research use. Alternative Names: 4-chloro-7-methoxyquinazolin-6-ol. CAS No. 574745-95-4. Molecular formula: C9H7ClN2O2. Mole weight: 210.62. Catalog: APB574745954.
Gefitinib Impurity 1
Gefitinib Impurity 1. Uses: For analytical and research use. CAS No. 1561173-24-7. Molecular formula: C15H22ClN3O3. Mole weight: 327.81. Catalog: APB1561173247.
Gefitinib Impurity 10. Uses: For analytical and research use. CAS No. 690206-97-4. Molecular formula: C16H13ClFN3O2. Mole weight: 333.75. Catalog: APB690206974.
Gefitinib Impurity 11
Gefitinib Impurity 11. Uses: For analytical and research use. CAS No. 16064-25-8. Molecular formula: C8H6N2O2. Mole weight: 162.15. Catalog: APB16064258.
Gefitinib Impurity 12
Gefitinib Impurity 12. Uses: For analytical and research use. CAS No. 385784-71-4. Molecular formula: C15H19N3O5. Mole weight: 321.33. Catalog: APB385784714.
Gefitinib Impurity 13
Gefitinib Impurity 13. Uses: For analytical and research use. CAS No. 215659-03-3. Molecular formula: C9H9NO6. Mole weight: 227.17. Catalog: APB215659033.
Gefitinib Impurity 15
Gefitinib Impurity 15. Uses: For analytical and research use. CAS No. 847949-50-2. Molecular formula: C22H25ClN4O4. Mole weight: 444.92. Catalog: APB847949502.
Gefitinib Impurity 19
Gefitinib Impurity 19. Uses: For analytical and research use. CAS No. 1803045-02-4. Molecular formula: C22H24ClFN4O4. Mole weight: 462.91. Catalog: APB1803045024.
Gefitinib impurity 2
Gefitinib impurity 2. Uses: For analytical and research use. Alternative Names: 4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate. Molecular formula: C17H13ClFN3O3. Mole weight: 361.75. Catalog: APB06237.
Gefitinib Impurity 23
Gefitinib Impurity 23. Uses: For analytical and research use. CAS No. 675126-28-0. Molecular formula: C15H20N2O3. Mole weight: 276.34. Catalog: APB675126280.
Gefitinib Impurity 24
Gefitinib Impurity 24. Uses: For analytical and research use. CAS No. 194423-17-1. Molecular formula: C10H12N4. Mole weight: 188.23. Catalog: APB194423171.
Gefitinib Impurity 25
Gefitinib Impurity 25. Uses: For analytical and research use. CAS No. 214472-41-0. Molecular formula: C16H24N2O5. Mole weight: 324.38. Catalog: APB214472410.
Gefitinib Impurity 26
Gefitinib Impurity 26. Uses: For analytical and research use. CAS No. 193552-54-4. Molecular formula: C18H16O6. Mole weight: 328.32. Catalog: APB193552544.
Gefitinib impurity 28
Gefitinib impurity 28. Uses: For analytical and research use. Alternative Names: N-(3-chloro-2-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine. Molecular formula: C22H24ClFN4O3. Mole weight: 446.9. Catalog: APB06233.
Gefitinib Impurity 28
Gefitinib Impurity 28. Uses: For analytical and research use. CAS No. 1379208-77-1. Molecular formula: C8H6N2O4. Mole weight: 194.15. Catalog: APB1379208771.
Gefitinib impurity 29
Gefitinib impurity 29. Uses: For analytical and research use. Alternative Names: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine. CAS No. 184475-35-2. Molecular formula: C22H24ClFN4O3. Mole weight: 446.9. Catalog: APB184475352.
Gefitinib impurity 3
Gefitinib impurity 3. Uses: For analytical and research use. Alternative Names: 4-((3,4-difluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate. Molecular formula: C17H13F2N3O3. Mole weight: 345.3. Catalog: APB06236.
Gefitinib Impurity 3. Uses: For analytical and research use. CAS No. 52805-46-6. Molecular formula: C8H7NO2. Mole weight: 149.15. Catalog: APB52805466.
Gefitinib impurity 30
Gefitinib impurity 30. Uses: For analytical and research use. Alternative Names: (E)-N'-(2-cyano-4,5-dimethoxyphenyl)-N,N-dimethylformimidamide. Molecular formula: C12H15N3O2. Mole weight: 233.27. Catalog: APB06232.
Gefitinib Impurity 30
Gefitinib Impurity 30. Uses: For analytical and research use. CAS No. 2347417-64-3. Molecular formula: C28H42N4O6S2. Mole weight: 594.79. Catalog: APB2347417643.
Gefitinib impurity 31
Gefitinib impurity 31. Uses: For analytical and research use. Alternative Names: N-(3-chloro-4-fluorophenyl)-6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-amine. Molecular formula: C22H24ClFN4O3. Mole weight: 446.9. Catalog: APB06231.
Gefitinib Impurity 31
Gefitinib Impurity 31. Uses: For analytical and research use. CAS No. 692059-41-9. Molecular formula: C12H12Cl2N2O2. Mole weight: 287.14. Catalog: APB692059419.
Gefitinib impurity 32
Gefitinib impurity 32. Uses: For analytical and research use. Alternative Names: 4,7-dimethoxyquinazolin-6-ol. Molecular formula: C10H10N2O3. Mole weight: 206.2. Catalog: APB06229.