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| Product | Description | |
|---|---|---|
| Gaultherin | Gaultherin. Group: Biochemicals. Alternative Names: Monotropitoside; Monotropitin. Grades: Plant Grade. CAS No. 490-67-5. Pack Sizes: 10mg. Molecular Formula: C19H26O12, Molecular Weight: 446.403. US Biological Life Sciences. |  Worldwide |
| Gavestinel | Gavestinel is a non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), displaying >1000-fold selectivity over NMDA, AMPA, and kainate binding sites. Gavestinel exhibits a neuroprotective property in animal models of ischaemic stroke. Uses: Glycine agents. Synonyms: 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, (E)-; 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-1H-indole-2-carboxylic acid; GV 150526; GV 150526X; (E)-4,6-dichloro-3-(3-oxo-3-(phenylamino)prop-1-en-1-yl)-1H-indole-2-carboxylic acid. Grade: ≥95%. CAS No. 153436-22-7. Molecular formula: C18H12Cl2N2O3. Mole weight: 375.21. |  |
| Gavestinel sodium salt | Gavestinel is a non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), displaying > 1000-fold selectivity over NMDA, AMPA and kainate binding sites. Gavestinel exhibits a neuroprotective property in animal models of ischaemic stroke. Synonyms: 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-, sodium salt (1:1); 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, monosodium salt, (E)-; GV 150526A. Grade: ≥98% by HPLC. CAS No. 153436-38-5. Molecular formula: C18H11Cl2N2O3Na. Mole weight: 397.19. | |
| Gaxilose | Gaxilose is a synthetic disaccharide and a substrate of intestinal lactase. It can be applicated in a new noninvasive diagnostic test based on urine or serum measurement of D-xylose after lactase cleavage of orally administered gaxilose. Uses: Used in a new noninvasive diagnostic test based on urine or serum measurement of d-xylose after lactase cleavage of orally administered 4-galactosylxylose. Synonyms: 4-O-Galactosyl-D-xylose; 4-O-Galactosylxylose; 4-Galactosylxylose; Gaxilose; (3R,4R,5R)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol. Grade: 98%. CAS No. 14087-31-1. Molecular formula: C11H20O10. Mole weight: 312.27. | |
| GB1107 | GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1978336-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114409. |  |
| GB-110 hydrochloride | GB-110 hydrochloride is a potent, and nonpeptidic protease activated receptor 2 (PAR2) agonist. It selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. Grade: 99%. Molecular formula: C33H49ClN6O5. Mole weight: 645.23. | |
| GB1908 | GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2573135-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-162561. | |
| GB1-Cyanine 3 | GB1-Cyanine 3. Group: Biochemicals. Alternative Names: 2-[3-[1-[17-(a-D-Glucopyranosyloxy)-5-oxo-9,12-dioxa-6,15-diazaheptadec-1-yl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1-propen-1-yl]-1,3,3-trimethyl-3H-indolium; GB1-Cy3. Grades: Highly Purified. CAS No. 1065004-53-6. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C43H63N4O9. US Biological Life Sciences. | Worldwide |
| GB83 | GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase?induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1252806-86-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-124061. | |
| GB 83 | GB 83 is a selective antagonist of human protease activated receptor 2 (PAR2) (IC50 = 2 mM). Synonyms: GB83; GB 83; GB-83; N-((S)-3-Cyclohexyl-1-((2S,3S)-1-(2,3-dihydrospiro[indene-1,4'-piperidine]-1'-yl)-3-methyl-1-oxopentan-2-ylamino)-1-oxopropan-2-yl)isoxazole-5-carboxamide. Grade: 99%. CAS No. 1252806-86-2. Molecular formula: C32H44N4O4. Mole weight: 548.72. | |
| GB-88 | GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416435-96-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120261. | |
| GBD-9 | GBD-9 is a degrader based on the E3 ubiquitin ligase CRBN that targets BTK and the G1 to S phase transition protein GSPT1. GBD-9 has both PROTAC and molecular glue properties by inducing ubiquitination and proteasomal degradation of target proteins. GBD-9 can efficiently degrade wild-type and mutant BTK (such as C481S mutation) and GSPT1. GBD-9 significantly inhibits tumor cell proliferation by inducing G1 phase arrest in cancer cells, downregulating anti-apoptotic proteins (BCL-2, MCL-1) and activating Caspase-3 to induce apoptosis. GBD-9 is mainly used in the research of hematological tumors such as diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML)[1][2][3].GBD-9 is composed of E3 ubiquitin ligase ligand (pink part) 5-Aminothalidomide (HY-W023573), target protein ligand (blue part) Btk Inhibitor: IBT6A (HY-13036A), and PROTAC linker (black part) Nonanoic acid (HY-N7057). Uses: Scientific research. Category: Signaling pathways. CAS No. 2864408-92-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153803. | |
| Gboxin | Gboxin is an oxidative phosphorylation inhibitor in cancer cells, which inhibits the activity of F0F1 ATP synthase. Synonyms: 2-ethyl-1-methyl-3-[2-[[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]oxy]-2-oxoethyl]-1H-benzimidazolium, monochloride. Grade: ≥98%. CAS No. 2101315-36-8. Molecular formula: C22H33N2O2·Cl. Mole weight: 392.96. | |
| Gboxin | Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F0F1 ATP synthase. Antitumour activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2101315-36-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111651. | |
| GBR 12783 | GBR 12783, a specific, potent and selective dopamine uptake inhibitor, inhibits the [3H]-dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. It can improve memory performance and increase hippocampal acetylcholine release in rats. Synonyms: Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-; 1-(2-(Diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine; 1-(2-(Benzhydryloxy)ethyl)-4-cinnamylpiperazine; 1-[2-(Diphenylmethoxy)ethyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine. Grade: ≥95%. CAS No. 67469-57-2. Molecular formula: C28H32N2O. Mole weight: 412.57. | |
| GBR 12783 dihydrochloride | GBR 12783 dihydrochloride is a potent and selective inhibitor of dopamine uptake (IC50 for inhibition of [3H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM). Synonyms: GBR 12783 dihydrochloride; GBR12783 dihydrochloride; GBR-12783 dihydrochloride; 1-(2-Diphenylmethoxyethyl)-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 67469-75-4. Molecular formula: C28H32N2O.2HCl. Mole weight: 485.5. | |
| GBR 12783 dihydrochloride | GBR 12783 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 67469-75-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GBR 12783 dihydrochloride | GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67469-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-100968. | |
| GBR 12909 Dihydrochloride | A potent inhibitor of dopamine active transporter (DAT, Ki=1nM, IC50=40 and 51nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models. Group: Biochemicals. Alternative Names: 1-[2-[Bis (4-fluorophenyl) methoxy]ethyl]-4- (3-phenylpropyl) -piperazine Dihydrochloride (9CI); GBR 12909; I 893; Vanoxerine Dihydrochloride; 1-[2-[Bis (4-fluorophenyl) methoxy]ethyl]-4- (3-phenylpropyl) -piperazine Hydrochloride (1:2). Grades: Highly Purified. CAS No. 67469-78-7. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??F?N?O 2HCl, Molecular Weight: 450.56 (anhydrous). US Biological Life Sciences. | Worldwide |
| GBR-12935 | GBR 12935 is a piperazine derivative and a potent and selective inhibitor of dopamine uptake with IC50 value of 3.7nM. It is found to have multiple binding sites in rat and human brains. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. It(1-9 nM) dose-dependently inhibited active uptake of [3H]dopamine in homogenates of the nucleus accumbens and could inhibit DA uptake with IC50 value of 3.7nM in vitro. It elevated locomotion to a greater extent in C57BL/6J mice at the maximally active dose of 10 mg/kg in vivo. It shows a Kd value of 1.08nM in dopamine transporter transfected COS-7 cells. It is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain. Uses: Gbr 12935 inhibits da uptake with ic50 value of 3.7nm in vitro. it elevated locomotion to a greater extent in c57bl/6j mice at the maximally active dose of 10 mg/kg in vivo. it shows a kd value of 1.08nm in dopamine transporter transfected cos-7 cells. Synonyms: GBR-12935; GBR 12935; GBR12935; 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine; 1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine; Piperazine, 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)-; N-[3-tert-Butyl-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N-[4-[2-(4-Morpholinyl)ethoxy]naphthalen-1-yl]urea; 1-(2-(Benzhydryloxy)e | |
| GBR-12935 | GBR-12935. CAS No. 9060-5-3. |  |
| GBR 12935 dihydrochloride | GBR 12935 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 67469-81-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GBR-12935 dihydrochloride | GBR 12935 2Hcl is a potent, and selective dopamine reuptake inhibitor. Synonyms: GBR12935 dihydrochloride; GBR-12935 dihydrochloride. Grade: 0.99. CAS No. 67469-81-2. Molecular formula: C28H36Cl2N2O. Mole weight: 487.509. | |
| GBR 13069 dihydrochloride | GBR 13069 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 67469-45-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GBR 13069 dihydrochloride | GBR 13069 dihydrochloride is a potent and selecticve inhibitor of dopamine uptake (IC50 = 40 nM). Synonyms: GBR 13069 dihydrochloride; GBR13069 dihydrochloride; GBR-13069 dihydrochloride; (1-(2-(Bis-(4-fluorophenyl)methoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride. CAS No. 67469-45-8. Molecular formula: C28H30F2N2O.2HCl. Mole weight: 521.48. | |
| GBT-440 | GBT-440 is a substituted benzaldehyde compound that can modulate sickle hemoglobin (HbS) for treatment of disorders. Uses: Hematologic agents. Synonyms: Voxelotor, GBT-440, GBT 440, GBT440, GTx-011, GTx011, GTx 011; 2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde; Hemoglobin Modulators-1. Grade: >98%. CAS No. 1446321-46-5. Molecular formula: C19H19N3O3. Mole weight: 337.37. | |
| GBT 440 hydrochloride | GBT 440 hydrochloride is an oral medication used to treat sickle cell disease in patients aged 12 and older. It functions by increasing hemoglobin's affinity for oxygen, which helps prevent red blood cell sickling and reduces associated complications. GBT 440 hydrochloride is a hemoglobin S (HbS) polymerization inhibitor. It binds to hemoglobin, stabilizing the hemoglobin molecule in its oxygenated form. This prevents the sickling of red blood cells and reduces the associated hemolysis and vaso-occlusive events. Synonyms: 2-Hydroxy-6-{[2-(1-isopropyl-1H-pyrazol-5-yl)-3-pyridinyl]methoxy}benzaldehyde hydrochloride (1:1); Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-, hydrochloride (1:1); 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde hydrochloride; GBT-440 hydrochloride; GBT440 hydrochloride; Voxelotor hydrochloride; Oxbryta hydrochloride; Hemoglobin Modulators-1 hydrochloride. Grade: ≥95%. CAS No. 1667717-41-0. Molecular formula: C19H20ClN3O3. Mole weight: 373.84. | |
| GC 1 | GC 1. Group: Biochemicals. Grades: Purified. CAS No. 211110-63-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| GC 14 | GC 14 is a selective antagonist of thyroid hormone receptor (THR), with IC50s of 35 and 200 nM for hTRβ and hTRα, respectively. Synonyms: Thyromimetic, 5a; {4-[(6-Hydroxy-5-isopropyl-4'-nitro-3-biphenylyl)methyl]-3,5-dimethylphenoxy}acetic acid; Acetic acid, 2-[4-[[6-hydroxy-5-(1-methylethyl)-4'-nitro[1,1'-biphenyl]-3-yl]methyl]-3,5-dimethylphenoxy]-. Grade: ≥95%. CAS No. 447415-34-1. Molecular formula: C26H27NO6. Mole weight: 449.50. | |
| GC376 | GC376 Inhibitor. Uses: Scientific use. Product Category: T5188. CAS No. 1416992-39-6. |  |
| GC376 sodium | GC376 sodium is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416992-39-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-100721. | |
| GC376 sodium | GC376 is a 3CLpro inhibitor which is previously reported to be active against the 3CLpro of multiple coronaviruses, including SARS-CoV, but with highest potency against FIPV in cell culture. GC376 inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM. Synonyms: GC376 sodium; GC 376 sodium; GC-376 sodium; (2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate sodium. Grade: ≥98% (HPLC). CAS No. 1416992-39-6. Molecular formula: C21H30N3NaO8S. Mole weight: 507.53. | |
| GC7 Sulfate | GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 150417-90-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108314A. | |
| GC7 Sulfate | GC7 Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). Synonyms: N1-guanyl-1,7-diaminoheptane Sulfate; GC 7 Sulfate; GC-7 Sulfate. CAS No. 150417-90-6. Molecular formula: C8H22N4O4S. Mole weight: 270.35. | |
| Gcase activator 2 | Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2759897-35-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-154823. | |
| Gcase activator 3 | Gcase activator 3 (compound 9Q) is a glucosidase (Glucosidase, GCase) activator that can partially stabilize GCase and increase its activity. Gcase activator 3 reduces mutant GCase protein misfolding and degradation in fibroblasts and dopaminergic midbrain neurons. Gcase activator 3 can be used in the study of Parkinson's disease (PD) and related synucleinopathies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2270984-21-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160426. | |
| GCB Graphitized Carbon Black | GCB Graphitized Carbon Black. CAS No. 7440-44-0. Product ID: ACM7440440-197. Mole weight: 12.011g/mol. IUPAC Name: carbon. ECNumber: 231-153-3;215-609-9;231-953-2;231-955-3;240-383-3;231-153-3;264-846-4;603-226-3;612-159-9;619-291-6. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| GCB Graphitized Carbon Black | Carbon black oil appears as a dark colored liquid with a petroleum-like odor. Less dense than water and insoluble in water. Vapors heavier than air.;Carbon, activated is a black grains that have been treated to improve absorptive ability. May heat spontaneously if not properly cooled after manufacture.;Carbon, animal or vegetable origin appears as a black powder or granular mixed with a tar or starch and water binder pressed into regular lumps or briquettes. Heats slowly and ignites in air especially if wet.;Graphite (natural) appears as a mineral form of the element carbon. Hexagonal crystals or thin leaf-like layers. Steel-gray to black with a metallic luster and a greasy feel. An electrical conductor. Used for high-temperature crucibles, as a lubricant and in "lead" pencils.;DryPowder; DryPowder, Liquid; DryPowder, PelletsLargeCrystals; DryPowder, PelletsLargeCrystals, WetSolid, OtherSolid, Liquid; DryPowder, WetSolid, Liquid; Liquid; OtherSolid; OtherSolid, GasVapor, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid, Liquid; WetSolid; WetSolid, Liquid;OtherSolid; PelletsLargeCrystals;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSolid;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; DryPowder, WetSolid; Liquid; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSol | |
| G(Cbz)-acetic acid | G(Cbz)-acetic acid. CAS No. 169287-69-8. Molecular formula: C15H13N5O5. Mole weight: 343.29. | |
| GC Enhancer | GC Enhancer. Gc enhancer should be used with dna ploymerase to optimize pcr from complex templates including gc rich. the storage concentration is 10×. the working concentration can adjust between 0.5×-5×. Group: Cloning Enzymes. Purity: 200ul. Storage: Store at -20 ?. Cat No: CE-3007. |  |
| Gc-globulin from human plasma | Gc-globulin from human plasma. Uses: For analytical and research use. CAS No. 68476-36-8. Catalog: AP68476368-A. |  |
| GcLEAP-2 | GcLEAP-2 is isolated from tenopharyngodon idella [Grass carp] and has antimicrobial activity. | |
| GCN2 activator-1 | GCN2 activator-1 (Compound 20) is a GCN2 activator. GCN2 activator-1 binds within the ATP-pocket of GCN2 and activates GCN2 in a GCN1-independent manner. GCN2 activator-1 activates Integrated Stress Response (ISR) in cells. GCN2 activator-1 inhibits PKR with an IC50 of 3.75 μM. GCN2 activator-1 can be used for research of pulmonary veno-occlusive disease (PVOD)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315705-10-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W319647. | |
| GCN2iB | GCN2iB is an ATP-competitive inhibitor of serine/threonine-protein kinase general control nonderepressible 2 (GCN2) with IC50 of 2.4 nM. Synonyms: N-[3-[2-(2-Amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxy-3-pyridinesulfonamide. CAS No. 2183470-12-2. Molecular formula: C18H12ClF2N5O3S. Mole weight: 451.83. | |
| GCN2iB | GCN2iB is an ATP-competitive, selective GCN2 inhibitor with an IC50 of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2183470-12-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112654. | |
| GCN2-IN-1 | GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448693-69-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100877. | |
| GCN2-IN-6 | GCN2-IN-6 is a potent and orally available inhibitor of GCN2 confirmed by in-house enzymatic (IC50 = 1.8 nM) and cellular assays (IC50 = 9.3 nM). It is also an eIF2α kinase PERK inhibitor with IC50s of 0.26 nM and 230 nM in enzymatic assay and in cells, respectively. Synonyms: Benzenesulfonamide, N-[3-[2-(2-amino-5-pyrimidinyl)ethynyl]-2,4-difluorophenyl]-2,5-dichloro-3-(hydroxymethyl)-; N-{3-[(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl}-2,5-dichloro-3-(hydroxymethyl)benzene-1-sulfonamide. Grade: ≥97%. CAS No. 2183470-09-7. Molecular formula: C19H12Cl2F2N4O3S. Mole weight: 485.29. | |
| GCN2-IN-6 | GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1]. GCN2-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2183470-09-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-130240. | |
| GCN2-IN-7 | GCN2-IN-7 (compound 39) is an orally active and selective general control nonderepressible 2 (GCN2) inhibitor (IC50=5 nM). GCN2-IN-7 shows anti-tumor activity in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2396465-33-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151460. | |
| GD1b-Ganglioside | GD1b-Ganglioside is a pivotal biomolecule, finding widespread application for the comprehensive investigation and comprehension of diverse neurodegenerative ailments, including Parkinson's disease is alzheimer's disease and Multiple Sclerosis. Synonyms: Ganglioside GD1b; Ganglioside C1; Ganglioside G2; Ganglioside G2 (hexasaccharide); Ganglioside GIII; GD1b; GD1b ganglioside. CAS No. 19553-76-5. Molecular formula: C80H144N4O37. Mole weight: 1754. | |
| GD1b-Oligosaccharide | GD1b-Oligosaccharide is a crucial component widely used in the research of neurological diseases, including Alzheimer's and Parkinson's. With its bioactive properties, GD1b-Oligosaccharide holds promise for targeted drug delivery systems, disease diagnostics and advanced research in neurobiology. Synonyms: Galb1-3GalNAcb1-4(Neu5Aca2-8Neu5Aca2-3)Galb1-4Glc. Molecular formula: C48H77N3O37Na2. Mole weight: 1334.10. | |
| GD2-Ganglioside | GD2-Ganglioside is a complex lipid molecule extensively present within the neuroblastoma tumours cells. This molecule is the focal point of numerous immunotherapies such as chimeric antigen receptor (CAR) T-cell therapy and monoclonal antibodies and has the ability to specifically recognize and demolish GD2-Ganglioside expressing cancer cells. Synonyms: Ganglioside GD2; Disialoganglioside-GD2; Disialoganglioside GD2; GD2. CAS No. 65988-71-8. | |
| GD2-GANGLIOSIDE | GD2-GANGLIOSIDE. CAS No. 65988-71-8. Purity: 95%. Product ID: ACM65988718. Molecular formula: C74H134N4O32. Mole weight: 1591.86. Alfa Chemistry - ISO 9001:32057 Certified. | |
| Gd2O3 nanopowder | Gd2O3 nanopowder. Purity: 99.9% (REO). | |
| GD2-Oligosaccharide | GD2-Oligosaccharide is a biomedical product used in the research of neuroblastoma. It has been found to target the GD2 antigen present on neuroblastoma cells. Synonyms: GalNAcβ1-4(Neu5Acα2-8Neu5Acα2-3)Galβ1-4Glc. Molecular formula: C42H67N3O32Na2. Mole weight: 1171.96. | |
| GD2-Oligosaccharide-b-(N-acetyl-propargyl) | GD2-Oligosaccharide-b-(N-acetyl-propargyl) is a remarkable biomedical compound, emerging as a formidable compound in the research of neuroblastoma, an affliction predominantly encountered during early stages of life. Synonyms: GD2-Saccharide-b-NAc-propargyl. Molecular formula: C47H72N4O32Na2. Mole weight: 1251.06. | |
| GD2-Oligosaccharide-desthiobiotin | GD2-Oligosaccharide-desthiobiotin is a compound product used in the research of GD2-positive cancers, composed of desthiobiotin and GD2 oligosaccharide. It specifically targets GD2 receptors on cancer cells. Molecular formula: C65H106N10O37.2Na. Mole weight: 1665.56. | |
| GD2-Oligosaccharide-sp-biotin | GD2-Oligosaccharide-sp-biotin is a powerful tool used for researching various diseases such as neuroblastoma, melanoma and certain other cancers. It specifically targets GD2 oligosaccharide. The addition of biotin enables efficient detection and purification of GD2 oligosaccharide in experimental settings. Molecular formula: C65H104N10O37SNa2. Mole weight: 1695.61. | |
| GD3-Ganglioside | GD3-Ganglioside, a glycosphingolipid, is an intricate modulator of cell growth, differentiation and apoptosis. Anti-cancer therapies utilizing GD3-Ganglioside as a therapeutic target have shown significant promise, making it a distinguished focus of research in the realm of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In addition to the fascinating roles delineated above, GD3-Ganglioside has been extensively studied for its potential as an antiviral agent owing to its involvement in the immune response. Synonyms: Ganglioside GD3; Disialohematoside; Disialohematoside GD3; Disialosyllactosylceramide; Ganglioside D3; GD3. CAS No. 62010-37-1. | |
| GD3-Ganglioside, biotin labelled | GD3-Ganglioside, biotin labelled. | |
| GDC-0068 dihydrochloride | Testing against a broad panel of 230 kinases, GDC-0068 only inhibits 3 kinases by >70% at 1 μM concentration (PRKG1α, PRKG1β, and p70S6K, with IC50 of 98 nM, 69 nM, and 860 nM, respectively). GDC-0068 displays >100-fold selectivity for Akt over PKA with IC50 of 3.1 μM. In LNCaP, PC3 and BT474M1 cells, GDC-0068 treatment inhibits the phosphorylation of the Akt substrate, PRAS40 with IC50 of 157 nM, 197 nM, and 208 nM, respectively. Furthermore, GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by Akt signaling, including those with defects in the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2, with strongest effects in HER2+ and Luminal subtypes. Oral administration of GDC-0068 in PC3 prostate tumor xenografts model induces down-regulation of p-PRAS40. In BT474-Tr xenografts, GDC-0068 treatment reduces pS6 and peIF4G levels, re-localizes FOXO3a to nucleus, and induces feedback upregulation of HER3 and pERK. Administration of GDC-0068 exhibits potent antitumor efficacy in multiple xenograft tumor models, including the PTEN-deficient prostate cancer models LNCaP and PC3, the PIK3CA H1047R mutant breast cancer model KPL-4, and MCF7-neo/HER2 tumor model. Synonyms: Ipatasertib dihydrochloride; RG-7440 dihydrochloride; GDC-0068 dihydrochloride; RG 7440 dihydrochloride; GDC 0068 dihydrochloride; RG7440 dihydrochloride; GDC0068 | |
| GDC-0077 | GDC-0077 is an orally available and selective PI3K inhibitor (IC50 = 0.038 + 0.003 nM) with > 300-fold selective over other Class I PI3K isoforms. GDC-0077 exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Synonyms: GDC 0077; GDC0077; Inavolisib. CAS No. 2060571-02-8. Molecular formula: C18H19F2N5O4. Mole weight: 407.37. | |
| GDC-0077 (Inavolisib) | Inavolisib (GDC-0077, RG6114, RO-7113755) is a potent selective inhibitor of PI3K alpha (PI3Kα) with an IC50 of 0.038 nM. GDC-0077 is >300-fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000-fold more selective over PIK family members. GDC-0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3. Group: Inhibitors. Alternative Names: RG6114, RO-7113755. CAS No. 2060571-02-8. Pack Sizes: 5mg. Product ID: S8668. Formula: C18H19F2N5O4. Smiles: CC(C(=O)N)NC1=CC2=C(C=C1)C3=NC(=CN3CCO2)N4C(COC4=O)C(F)F. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| GDC-0084 | GDC-0084, a PI3K inhibitor, has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration. It was just licensed to Novogen and start a Phase II trial for Glioma. Uses: Gdc-0084 is a pi3k inhibitor that has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration. Synonyms: RG7666; RG-7666; RG 7666; GDC-0084; GDC0084; GDC 0084; 5-(6,6-dimethyl-4-morpholin-4-yl-8,9-dihydropurino[8,9-c][1,4]oxazin-2-yl)pyrimidin-2-amine. Grade: 98%. CAS No. 1382979-44-3. Molecular formula: C18H22N8O2. Mole weight: 382.19. | |
| GDC-0152 | GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of ML-IAP with Ki values of 28 nM, 17 nM, 43 nM and 14 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 873652-48-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13638. | |
| GDC-0152 | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Synonyms: GDC-0152; GDC0152; GDC 0152. CAS No. 873652-48-3. Molecular formula: C25H34N6O3S. Mole weight: 498.646. | |
| GDC-0214 | GDC-0214 is a highly potent, selective and inhalable Janus kinase-1 (JAK-1) inhibitor. Synonyms: GDC 0214; GDC0214; iJak-381; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [3-(5-chloro-2-difluoromethoxy-phenyl)-1-(2-{4-[(2-cyano-ethyl)-methyl-amino]-piperidin-1-yl}-2-oxo-ethyl)-1H-pyrazol-4-yl]-amide. CAS No. 1831144-46-7. Molecular formula: C28H28ClF2N9O3. Mole weight: 612.04. | |
| GDC-0276 | GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1494581-70-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114237. | |
| GDC-0310 | Nav1.7 is an extensively investigated target for pain. GDC-0310 is a selective Nav1.7 inhibitor. Synonyms: UNII-72GO7NL642; GDC 0310. CAS No. 1788063-52-4. Molecular formula: C25H29Cl2FN2O4S. Mole weight: 543.48. | |
| GDC-0310 | GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1788063-52-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139081. | |
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