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| Product | Description | |
|---|---|---|
| IRAK-1-4 Inhibitor I | IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IRAK-1/4 Inhibitor I. CAS No. 509093-47-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13329. |  |
| IRAK4-IN-14 | IRAK4-IN-14 (compound 28) is a potent, selective and orally active IRAK4 inhibitor with an IC50 of 0.003 μM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2667681-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146112. | |
| IRAK4-IN-21 | IRAK4-IN-21 (compound 17) is an orally active, potent and selective IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC50=0.17 μM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170694-04-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-151363. | |
| IRAK4 modulator-2 | IRAK4 modulator-2 (Compound 5) is a selective dual Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and IRAK1 inhibitor with IC50 values of 0.005 μM and 0.97 μM, erespectively. IRAK4 modulator-2 blocks IRAK-mediated signaling pathways (e.g., JAK-STAT, NF-κB pathways), reduces the production of pro-inflammatory cytokines (e.g., IL-1, TNF), and exerts anti-inflammatory activity. IRAK4 modulator-2 is promising for research of autoimmune diseases and inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1356013-27-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-177515. | |
| IRAK-4 Peptide substrate | IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4). Uses: Scientific research. Category: Signaling pathways. Alternative Names: IRAK-1 (360-380). CAS No. 2837877-90-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5432. | |
| IRAK inhibitor 3 | IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1012343-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13277. | |
| Irbesartan | Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR-47436; BMS-186295. CAS No. 138402-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0202. | |
| Irbesartan | An angiotensin II type 1 (AII1)-receptor antagonist. Group: Biochemicals. Alternative Names: 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one; BMS-186295; SR-47436; Aprovel; Avapro. Grades: Highly Purified. CAS No. 138402-11-6. Pack Sizes: 10g, 25g, 50g, 100g. Molecular Formula: C??H??N?O, Molecular Weight: 428.53. US Biological Life Sciences. |  Worldwide |
| Irbesartan | Irbesartan (SR-47436, BMS-186295) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM. Synonyms: BMS-186295, SR-47436; BMS 186295, SR 47436; BMS186295, SR47436. Grade: >98%. CAS No. 138402-11-6. Molecular formula: C25H28N6O. Mole weight: 428.53. |  |
| Irbesartan | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C25H28N6O. CAS No. 138402-11-6. Prepack ID 30308321-1g. Molecular Weight 428.53. See USA prepack pricing. |  |
| Irbesartan (2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, BMS-186295, SR-47436, Aprovel, Avapro) | An angiotensin II type 1 (AII1)-receptor antagonist. Group: Biochemicals. Alternative Names: 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one, BMS-186295, SR-47436, Aprovel, Avapro. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Irbesartan-d4 | Irbesartan-d4. Group: Biochemicals. Grades: Highly Purified. CAS No. 138402-11-6. Pack Sizes: 1g, 2g, 5g, 10g. Molecular Formula: C25H24D4N6O. US Biological Life Sciences. | Worldwide |
| Irbesartan-[d4] | Irbesartan-[d4] is the labelled analogue of Irbesartan, which is a highly potent and specific angiotensin II type 1 receptor antagonist. Uses: The isotope labeled form of irbesartan. Synonyms: Irbesartan D4; 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one-d4; BMS-186295-d4; SR-47436-d4; Aprovel-d4; Avapro-d4. Grade: 98%; ≥98% atom D. CAS No. 1216883-23-6. Molecular formula: C25H24D4N6O. Mole weight: 432.55. | |
| Irbesartan-[d6] | Irbesartan-[d6] is an isotopically labelled analogue of Irbesartan, which is an angiotensin II type 1 (AII1)-receptor antagonist. Synonyms: 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl-d2)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one; Irbesartan-d6; 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one-d6; Irbesartan-d6 (benzyl-d6). Grade: 98% by CP; 98% atom D. CAS No. 2375621-21-7. Molecular formula: C25H22D6N6O. Mole weight: 434.57. | |
| Irbesartan-d7 | Labeled Irbesartan, an angiotensin II type 1 (AII1)-receptor antagonist. Group: Biochemicals. Alternative Names: 2-Butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one-d7. Grades: Highly Purified. CAS No. 1329496-43-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Irbesartan EP Impurity A | Irbesartan EP Impurity A. Uses: For analytical and research use. CAS No. 748812-53-5. Molecular formula: C25H30N6O2. Mole weight: 446.56. Catalog: APB748812535. |  |
| Irbesartan EP Impurity B | Irbesartan EP Impurity B. Uses: For analytical and research use. CAS No. 14343-69-2. Molecular formula: N3-. Mole weight: 42.01. Catalog: APB14343692. | |
| Irbesartan Impurity 1 | Irbesartan Impurity 1. Uses: For analytical and research use. Molecular formula: C25H28N6O. Mole weight: 428.54. Catalog: APB08265. | |
| Irbesartan Impurity 10 ( Dimer) | Irbesartan Impurity 10 ( Dimer). Uses: For analytical and research use. CAS No. 1346598-52-4. Molecular formula: C39H38N10O. Mole weight: 662.8. Catalog: APB1346598524. | |
| Irbesartan Impurity 12 | Irbesartan Impurity 12. Uses: For analytical and research use. CAS No. 138401-24-8. Molecular formula: C25H27N3O. Mole weight: 385.51. Catalog: APB138401248. | |
| Irbesartan Impurity 14 | Irbesartan Impurity 14. Uses: For analytical and research use. CAS No. 133690-91-2. Molecular formula: C14H10N4. Mole weight: 234.26. Catalog: APB133690912. | |
| Irbesartan Impurity 15 Sodium Salt | Irbesartan Impurity 15 Sodium Salt. Uses: For analytical and research use. CAS No. 1145664-35-2. Molecular formula: C14H10N7Na. Mole weight: 299.27. Catalog: APB1145664352. | |
| Irbesartan Impurity 19 | Irbesartan Impurity 19. Uses: For analytical and research use. CAS No. 151257-01-1. Molecular formula: C11H19ClN2O. Mole weight: 230.74. Catalog: APB151257011. | |
| Irbesartan Impurity 20 | Irbesartan Impurity 20. Uses: For analytical and research use. CAS No. 143618-44-4. Molecular formula: C33H25N7. Mole weight: 519.61. Catalog: APB143618444. | |
| Irbesartan Impurity 21 | Irbesartan Impurity 21. Uses: For analytical and research use. CAS No. 1213252-83-5. Molecular formula: C25H26N6O. Mole weight: 426.52. Catalog: APB1213252835. | |
| Irbesartan Impurity 22 | Irbesartan Impurity 22. Uses: For analytical and research use. CAS No. 1312996-19-2. Molecular formula: C21H20N6O2. Mole weight: 388.43. Catalog: APB1312996192. | |
| Irbesartan Impurity 23 | Irbesartan Impurity 23. Uses: For analytical and research use. CAS No. 2758005-15-9. Molecular formula: C14H11N3O2. Mole weight: 253.26. Catalog: APB2758005159. | |
| Irbesartan Impurity 24 | Irbesartan Impurity 24. Uses: For analytical and research use. CAS No. 2763750-28-1. Molecular formula: C14H12N4O. Mole weight: 252.28. Catalog: APB2763750281. | |
| Irbesartan Impurity 24 | Irbesartan Impurity 24. Uses: For analytical and research use. Alternative Names: 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-2-en-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile. Molecular formula: C25H27N3O. Mole weight: 385.22. Catalog: APB02064. | |
| Irbesartan Impurity 25 | Irbesartan Impurity 25. Uses: For analytical and research use. Alternative Names: 4'-((4-oxo-2-propyl-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile. Molecular formula: C24H25N3O. Mole weight: 371.20. Catalog: APB02063. | |
| Irbesartan Impurity 25 | Irbesartan Impurity 25. Uses: For analytical and research use. CAS No. 906474-58-6. Molecular formula: C23H20N6O4. Mole weight: 444.45. Catalog: APB906474586. | |
| Irbesartan Impurity 27 | Irbesartan Impurity 27. Uses: For analytical and research use. CAS No. 1079997-01-5. Molecular formula: C26H30N6O2. Mole weight: 458.57. Catalog: APB1079997015. | |
| Irbesartan Impurity 28 | Irbesartan Impurity 28. Uses: For analytical and research use. CAS No. 14309-25-2. Molecular formula: C19H15N3. Mole weight: 285.35. Catalog: APB14309252. | |
| Irbesartan Impurity 29 | Irbesartan Impurity 29. Uses: For analytical and research use. CAS No. 141745-36-0. Molecular formula: C23H26N6O. Mole weight: 402.5. Catalog: APB141745360. | |
| Irbesartan Impurity 3 | Irbesartan Impurity 3. Uses: For analytical and research use. CAS No. 138401-21-5. Molecular formula: C25H28N2O3. Mole weight: 404.51. Catalog: APB138401215. | |
| Irbesartan Impurity 30 | Irbesartan Impurity 30. Uses: For analytical and research use. Molecular formula: C14H9BrN4. Mole weight: 313.16. Catalog: APB08267. | |
| Irbesartan Impurity 31 | Irbesartan Impurity 31. Uses: For analytical and research use. Molecular formula: C14H9N7. Mole weight: 275.27. Catalog: APB08270. | |
| Irbesartan Impurity 32 | Irbesartan Impurity 32. Uses: For analytical and research use. Molecular formula: C14H10BrN7. Mole weight: 356.19. Catalog: APB08268. | |
| Irbesartan Impurity 33 | Irbesartan Impurity 33. Uses: For analytical and research use. Molecular formula: C14H10N10. Mole weight: 318.3. Catalog: APB08269. | |
| Irbesartan Impurity 34 | Irbesartan Impurity 34. Uses: For analytical and research use. Molecular formula: C14H10BrN3O2. Mole weight: 332.16. Catalog: APB08271. | |
| Irbesartan Impurity 35 | Irbesartan Impurity 35. Uses: For analytical and research use. Molecular formula: C14H10N6O2. Mole weight: 294.27. Catalog: APB08273. | |
| Irbesartan Impurity 36 | Irbesartan Impurity 36. Uses: For analytical and research use. Molecular formula: C14H11BrN4O. Mole weight: 331.17. Catalog: APB08272. | |
| Irbesartan Impurity 37 | Irbesartan Impurity 37. Uses: For analytical and research use. Molecular formula: C14H11N7O. Mole weight: 293.29. Catalog: APB08274. | |
| Irbesartan Impurity 4 | Irbesartan Impurity 4. Uses: For analytical and research use. CAS No. 945540-26-1. Molecular formula: C21H20N6O. Mole weight: 372.43. Catalog: APB945540261. | |
| Irbesartan Impurity 47 | Irbesartan Impurity 47. Uses: For analytical and research use. CAS No. 135689-88-2. Molecular formula: C14H10BrN. Mole weight: 272.14. Catalog: APB135689882. | |
| Irbesartan Impurity 48 | Irbesartan Impurity 48. Uses: For analytical and research use. Molecular formula: C14H9BrN4. Mole weight: 313.16. Catalog: APB08276. | |
| Irbesartan Impurity 5 | Irbesartan Impurity 5. Uses: For analytical and research use. CAS No. 1213252-81-3. Molecular formula: C25H28N6O. Mole weight: 428.54. Catalog: APB1213252813. | |
| Irbesartan Impurity 6 | Irbesartan Impurity 6. Uses: For analytical and research use. Molecular formula: C26H32N6O2. Mole weight: 460.58. Catalog: APB08266. | |
| Irbesartan Impurity 7 | Irbesartan Impurity 7. Uses: For analytical and research use. CAS No. 141745-71-3. Molecular formula: C25H29N3O2. Mole weight: 403.53. Catalog: APB141745713. | |
| Irbesartan Impurity 8 | Irbesartan Impurity 8. Uses: For analytical and research use. CAS No. 158778-58-6. Molecular formula: C24H26N6O. Mole weight: 414.51. Catalog: APB158778586. | |
| Irbesartan Impurity 9 | Irbesartan Impurity 9. Uses: For analytical and research use. CAS No. 144625-34-3. Molecular formula: C25H29N3O2. Mole weight: 403.53. Catalog: APB144625343. | |
| Irbesartan Related Compound A | Irbesartan Related Compound A. Uses: For analytical and research use. CAS No. 748812-53-5. Mole weight: 446.54. Catalog: AP748812535. | |
| IRBM-Z-1 | IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 1.8 μM. IRBM-Z-1 also exhibits inhibitory activity against the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 inhibits ZIKV replication, attenuates virus-induced cytopathic effects. IRBM-Z-1 is applicable to research related to ZIKV infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67629-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-181990. | |
| IRBP (1-20), human | IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP). Synonyms: L-Aspartic acid, glycyl-L-prolyl-L-threonyl-L-histidyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-seryl-L-leucyl-L-valyl-L-leucyl-L-α-aspartyl-L-methionyl-L-alanyl-L-lysyl-L-valyl-L-leucyl-L-leucyl-; Gly-Pro-Thr-His-Leu-Phe-Gln-Pro-Ser-Leu-Val-Leu-Asp-Met-Ala-Lys-Val-Leu-Leu-Asp. Grade: ≥95%. CAS No. 298202-25-2. Molecular formula: C101H164N24O28S. Mole weight: 2194.59. | |
| IRBP (1-20), human | IRBP (1-20), human contains a major epitope for the H-2b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 298202-25-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1587. | |
| IRBP(651-670) human, mouse | IRBP (651-670) human, mouse is an epitope and uveitis inducer naturally processed from the conserved region of native IRBP. IRBP (651-670) human, mouse increases the levels of proinflammatory cytokines in ocular tissues (IL-1β, IL-6, TNFα, IL-17A and IL-17F). IRBP (651-670) human, mouse is a IRBP fragment conserved among human, mouse and bovine species. IRBP (651-670) human, mouse induces experimental autoimmune uveitis. IRBP (651-670) human, mouse is applicable to research related to experimental autoimmune uveitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1977546-93-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1924. | |
| IRBP acetate | IRBP acetate, a 20-residue peptide and a main pathogenic epitope, is present in the first homologous repeat of IRBP 161-180, which induces posterior uveitis (EAU). Synonyms: Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) acetate; H-Ser-Gly-Ile-Pro-Tyr-Ile-Ile-Ser-Tyr-Leu-His-Pro-Gly-Asn-Thr-Ile-Leu-His-Val-Asp-OH.CH3CO2H; L-Serylglycyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-isoleucyl-L-seryl-L-tyrosyl-L-leucyl-L-histidyl-L-prolylglycyl-L-asparaginyl-L-threonyl-L-isoleucyl-L-leucyl-L-histidyl-L-valyl-L-aspartic acid acetic acid. Grade: ≥95%. Molecular formula: C105H161N25O31. Mole weight: 2269.55. | |
| IRBP derived peptide, R16 | IRBP derived peptide, R16 is a derivative of IRBP (Interphotoreceptor retinoid binding protein). Synonyms: H-Ala-Asp-Gly-Ser-Ser-Trp-Glu-Gly-Val-Gly-Val-Val-Pro-Asp-Val-OH; L-alanyl-L-alpha-aspartyl-glycyl-L-seryl-L-seryl-L-tryptophyl-L-alpha-glutamyl-glycyl-L-valyl-glycyl-L-valyl-L-valyl-L-prolyl-L-alpha-aspartyl-L-valine. CAS No. 145821-83-6. Molecular formula: C64H96N16O24. Mole weight: 1473.5. | |
| Ir(BT)2(acac) | Ir(BT)2(acac). Alternative Names: Bis(2-benzo[b]thiophen-2-ylpyridine)(acetylacetonate)iridium(III). CAS No. 337526-88-2. Molecular formula: C31H24IrN2O2S2-2. Mole weight: 711.87. Purity: 95%+. IUPAC Name: (Z)-4-hydroxypent-3-en-2-one;iridium;2-phenyl-1,3-benzothiazole. SMILES: O=C(C)/C=C(C)\O[Ir](C1=C(C2=NC=CC=C2)SC3=C1C=CC=C3)C4=C(C5=NC=CC=C5)SC6=C4C=CC=C6. InChI: 1S/2C13H8NS.C5H8O2.Ir/c2*1-2-7-12-10(5-1)9-13(15-12)11-6-3-4-8-14-11;1-4(6)3-5(2)7;/h2*1-8H;3,6H,1-2H3;/q;;;+1/p-1/b;;4-3-;,OUCQDKGXSKZJFL-DVACKJPTSA-M. |  |
| Ir(bt)2(acac); Bis(2-phenyl-benzothiazole-C2,N)(acetylacetonate)iridium(III), >99%(HPLC), Sublimed | Ir(bt)2(acac); Bis(2-phenyl-benzothiazole-C2,N)(acetylacetonate)iridium(III), >99%(HPLC), Sublimed. CAS No. 337526-88-2. Molecular formula: C31H24IrN2O2S2-2. Mole weight: 712.9g/mol. IUPAC Name: (Z)-4-hydroxypent-3-en-2-one;iridium;2-phenyl-1,3-benzothiazole. SMILES: CC(=CC(=O)C)O.C1=CC=C([C-]=C1)C2=NC3=CC=CC=C3S2.C1=CC=C([C-]=C1)C2=NC3=CC=CC=C3S2.[Ir]. InChI: InChI=1S/2C13H8NS.C5H8O2.Ir/c2*1-2-6-10(7-3-1)13-14-11-8-4-5-9-12(11)15-13;1-4(6)3-5(2)7;/h2*1-6,8-9H;3,6H,1-2H3;/q2*-1;;/b;;4-3-. | |
| Ir(btp)2(acac) | Ir(btp)2(acac). Alternative Names: Bis(2-(2-benzothienyl)pyridinato-N,C3)(acetylacetonate)iridium;Bis(2-benzo[b]thiophene-2-ylpyridine)(acetylacetonate)iridium(III);Bis[2-(2-benzothienyl)pyridinato-N,C3](acetylacetonato)iridium;Bis(2-(benzo[b]thiophen-2-yl)pyridine-C2,N)(acetylacetonato)i. CAS No. 343978-79-0. Molecular formula: C31H24IrN2O2S2-2. Mole weight: 711.87. Purity: 96%. IUPAC Name: Bis[2-(2-benzothienyl)pyridinato-N,C3](acetylacetonato)iridium. | |
| IR-Crizotinib | IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research. Category: Active pharmaceutical ingredients. CAS No. 2387927-74-2. Product ID: API2387927742. Molecular formula: C53H57Cl2FIN7O. Mole weight: 1024.88. |  |
| Irdabisant | Irdabisant (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively. Irdabisant has relatively low inhibitory activity against hERG current with an IC50 of 13.8 μM. Irdabisant has cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant can be used to research schizophrenia or cognitive impairment[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CEP-26401. CAS No. 1005402-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-109968. | |
| Ir-Def1 | Ir-Def1 is an antibacterial peptide isolated from Ixodes ricinus. It has activity against gram-positive bacteria. Synonyms: Ixodes ricinus defensin def1; Gly-Gly-Tyr-Tyr-Cys-Pro-Phe-Phe-Gln-Asp-Lys-Cys-His-Arg-His-Cys-Arg-Ser-Phe-Gly-Arg-Lys-Ala-Gly-Tyr-Cys-Gly-Gly-Phe-Leu-Lys-Lys-Thr-Cys-Ile-Cys-Val. | |
| Ir-Def2 | Ir-Def2 is an antibacterial peptide isolated from Ixodes ricinus. It has activity against gram-positive bacteria. Synonyms: Ixodes ricinus defensin def2; Gly-Gly-Tyr-Tyr-Cys-Pro-Phe-Arg-Gln-Asp-Lys-Cys-His-Arg-His-Cys-Arg-Ser-Phe-Gly-Arg-Lys-Ala-Gly-Tyr-Cys-Gly-Gly-Phe-Leu-Lys-Lys-Thr-Cys-Ile-Cys-Val. | |
| IRDye® 800CW Carboxylate | Near-infrared (NIR) fluorescent dye; Carboxylic acid available for covalent attachment; Supplied as polysodium salt; Used as a contrast agent by itself or for making optical probes for NIR fluorescence imaging. Synonyms: 800CW acid; IRDye 800CW Carboxylic acid; Sodium 6-(2-(2-(3-(2-(3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)-3H-indol-1-ium-2-yl)vinyl)-2-(4-sulfonatophenoxy)cyclohex-2-en-1-ylidene)ethylidene)-3,3-dimethyl-5-sulfonatoindolin-1-yl)hexanoate. Grade: 95%. CAS No. 1088919-86-1. Molecular formula: C46H50N2Na4O15S4. Mole weight: 1091.11. | |
| IRE1α Antibody [B12P6] | IRE1 alpha,IRE1α. Group: Antibodies. Alternative Names: IRE1α. Pack Sizes: 20ul. Product ID: F0229. Storage Conditions: -20°C (avoid freeze-thaw cycles), 2 years. |  United States; Europe |
| IRE1α kinase-IN-1 | IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2328097-41-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136735. | |
| IRE1 Inhibitor III, 4u8C (8-Formyl-7-hydroxy-4-methylcoumarin, 7-Hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde, ER-to-Nucleus Signaling 1 Inhibitor III, Inositol-Reguiring Protein 1 Inhibitor III) | A cell-permeable coumarin o-hydroxyaldehyde that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC50=550 and 45nM, respectively, with 0 and 16min drug preincubation in RNA cleavage assays) by covalently targeting IRE1 Lys907 via Schiff base formation, effectively preventing ER stress-induced site-specific mRNA splicing as well as RIDD (Regulated IRE1-Dependent Degradation) mRNA degradation (IC50=6.9 and 4.1uM, respectively, against Xbp1 splicing and Scara3 degradation) in MEF cultures following Tunicamycin treatment. Comparing to STF083010, 4u8C is also shown to inhibit IRE1 autophosphorylation in cell-free assays via Schiff base formation with IRE1 Lys599 in the absence of ADP, however cellular nucleotide prevents 4u8C from targeting IRE1 Lys599 intracellularly. Group: Biochemicals. Grades: Highly Purified. CAS No. 14003-96-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| IRF1-IN-1 | IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 701225-07-2. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-171006. | |
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