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| Product | Description | |
|---|---|---|
| Kukoamine A | Kukoamine A. Group: Biochemicals. Grades: Plant Grade. CAS No. 75288-96-9. Pack Sizes: 10mg. Molecular Formula: C28H42N4O6, Molecular Weight: 530.66. US Biological Life Sciences. |  Worldwide |
| Kukoamine B | Kukoamine B. Group: Biochemicals. Grades: Plant Grade. CAS No. 164991-67-7. Pack Sizes: 10mg. Molecular Formula: C28H42N4O6, Molecular Weight: 530.66. US Biological Life Sciences. | Worldwide |
| Kumbicin C | Kumbicin C is a bis-indolyl benzenoid fungal metabolite produced by A. kumbius FRR6049. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 = 0.74 μg/mL) and the Gram-positive bacterium Bacillus subtilis (MIC = 1.6 μg/mL). Synonyms: 5,8-di-1H-indol-3-yl-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-ol. Grades: ≥95%. CAS No. 1878151-58-6. Molecular formula: C28H24N2O3. Mole weight: 436.50. |  |
| Kumquat Base | Kumquat Base. CAS No. MIXTURE. VIGON Item # 504913. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. |  America & Internationally |
| Kunitz-type serine protease inhibitor 1 | Kunitz-type serine protease inhibitor 1 is a Kunitz protease inhibitor isolated from Xanthosoma sagittifolium. It has activity against gram-negative bacteria. Synonyms: Pro-Val-Val-Asp-Thr-Thr-Gly-Asn-Asn-Pro-Leu-Gln-Gln-Gln-Glu-Glu-Tyr-Tyr-Val. Grades: 96.4%. Molecular formula: C96H144N24O35. Mole weight: 2194.34. | |
| kunzeaol synthase | Isolated from the root of the plant Thapsia garganica. The enzyme also produces germacrene D, bicyclogermacrene and traces of other sesquiterpenoids. See EC 4.2.3.77, (+)-germacrene D synthase and EC 4.2.3.100, bicyclogermacrene synthase. Group: Enzymes. Synonyms: TgTPS2 (gene name). Enzyme Commission Number: EC 4.2.3.143. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5157; kunzeaol synthase; EC 4.2.3.143; TgTPS2 (gene name). Cat No: EXWM-5157. |  |
| Kurarinone | Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 34981-26-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2279. |  |
| Kurarinone | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Kurarinone | Kurarinone. Group: Biochemicals. CAS No. 34981-26-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kurarinone, 2'-O-methyl- | Kurarinone, 2'-O-methyl-. Group: Biochemicals. Grades: Plant Grade. CAS No. 270249-38-2. Pack Sizes: 5mg. Molecular Formula: C27H32O6, Molecular Weight: 452.55. US Biological Life Sciences. | Worldwide |
| Kurasoin A | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin A has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin A; (S)-3-Hydroxy-4-(4-hydroxyphenyl)-1-phenyl-2-butanone. CAS No. 182232-62-8. Molecular formula: C16H16O3. Mole weight: 256.30. | |
| Kurasoin B | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin B has the effect of inhibiting the protein fannicyl transferase. Synonyms: (+)-Kurasoin B. Molecular formula: C18H17NO2. Mole weight: 279.33. | |
| Kuromanin chloride | Kuromanin chloride is a natural compound found in Amelanchier spicata, Acer paxii. It is a scavenger of peroxynitrite and that exert a protective effect against endothelial dysfunction and vascular failure induced by peroxynitrite. Uses: Antioxidative. Synonyms: Kuromanine; Chrysontemin; Cyanidin-3-glucoside chloride. Grades: >98%. CAS No. 7084-24-4. Molecular formula: C21H21O11 Cl. Mole weight: 484.85. | |
| Kuromanin chloride | Kuromanin chloride (Chrysontemin) is derived from mulberry leaves and has the effect of increasing blood sugar concentration and maintaining lipid metabolism balance to reduce obesity. Kuromanin chloride can inhibit CD38 enzymatic activities[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: Chrysontemin; Cyanidin 3-O-glucoside chloride. CAS No. 7084-24-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0640. | |
| Kuromanin Chloride | Cyanidin-3-glucoside chloride. CAS No. 7084-24-4. Product ID: 3-02461. Molecular formula: C21H21ClO11. Mole weight: 484.84. |  |
| KUS121 | KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357164-52-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-138233. | |
| Kushenol A | Kushenol A. Group: Biochemicals. Grades: Plant Grade. CAS No. 99217-63-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kushenol F (Sophoraflavanone G) | Kushenol F (Sophoraflavanone G). Group: Biochemicals. Alternative Names: 2?,4?,5,7-Tetrahydroxy-6-lavandulylflavanone; Norkurarinone;34981-24-3. Grades: Plant Grade. CAS No. 97938-30-2. Pack Sizes: 10mg. Molecular Formula: C25H28O6, Molecular Weight: 424.485999999999. US Biological Life Sciences. | Worldwide |
| Kushenol I | Kushenol I. Group: Biochemicals. Grades: Plant Grade. CAS No. 99119-69-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kushenol I | Kushenol I is a compound of the flavonoid class found in the Sophora flavescens Ait. Kushenol I is a GABAA receptor modulator and a Sodium-dependent glucose cotransporter 2(SGLT2) inhibitor. Synonyms: NSC 668937. Grades: >98%. CAS No. 99119-69-4. Molecular formula: C26H30O7. Mole weight: 454.5. | |
| Kushenol K | Kushenol K, a flavonoid antioxidant isolated from the roots of Sophora flavescens. Kushenol K is a cytochrome P-450 3A4 (CYP3A4) inhibitor with a Ki value of 1.35 μM. Kushenol K shows weak antiviral activity against HSV-2 (EC50 of 147 μM). Kushenol K also inhibits the activity of SGLT1 and SGLT2. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 101236-49-1. Molecular formula: C26H32O8. Mole weight: 472.53. Product ID: ACM101236491. Alfa Chemistry ISO 9001:2015 Certified. |  |
| KuWal151 | KuWal151 is a potent and selective CLK inhibitor with IC50 values of 28, 88 and 510 nM for CLK4, 1 and 2, respectively. It inhibits growth of a range of cancer cell lines at subnanomolar concentrations. Synonyms: 3-(3-Chlorophenyl)-6,7-dihydropyrrolo[3,4-g]indol-8(1H)-one. Grades: ≥98% by HPLC. CAS No. 2341841-06-1. Molecular formula: C16H11ClN2O. Mole weight: 282.72. | |
| Kuwanon A | Kuwanon A, a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.), inhibits nitric oxide production (IC50 = 10.5 μM). Synonyms: 5,7-dihydroxy-2-(5-hydroxy-2,2-dimethylchromen-8-yl)-3-(3-methylbut-2-enyl)chromen-4-one. CAS No. 62949-77-3. Molecular formula: C25H24O6. Mole weight: 420.45. | |
| Kuwanon A | Kuwanon A. Group: Biochemicals. CAS No. 62949-77-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kuwanon E | Kuwanon E. Group: Biochemicals. CAS No. 68401-05-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kuwanon G | Kuwanon G is a flavonoid isolated from Morus alba, acts as a bombesin receptor antagonist, with potential antimicrobial activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: kuwanon G;8-[(1S)-6α-(2,4-Dihydroxybenzoyl)-5β-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1β-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;Albanin F;Moracenin B;NSC 356888. Product Category: Inhibitors. Appearance: Solid. CAS No. 75629-19-5. Molecular formula: C40H36O11. Mole weight: 692.71. Purity: 0.95. Canonical SMILES: O=C1C(C/C=C(C)\C)=C(C2=CC=C(O)C=C2O)OC3=C([C@H]4C=C(C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=CC(O)=C13. Product ID: ACM75629195. Alfa Chemistry ISO 9001:2015 Certified. | |
| Kuwanon G | Kuwanon G. Group: Biochemicals. Grades: Highly Purified. CAS No. 75629-19-5. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C40H36O11. US Biological Life Sciences. | Worldwide |
| Kuwanon H | Kuwanon H. Group: Biochemicals. CAS No. 76472-87-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Kuwanon K | Kuwanon K is a natural product that can be isolated from Morus Lhou [1]. Uses: Scientific research. Group: Natural products. CAS No. 88524-66-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11463. | |
| Kv1.3 Channel blocker 42 | Kv1.3 Channel blocker 42 is a selective potassium channel blocker of Kv1.3 current (IC50 < 50 nM). Kv1.3 channel blocker is promisingly used for the treatment of obesity and insulin resistance. Synonyms: Kv1.3 Channel blocker 42; 2108780-57-8; E98959; 1-(7-(3-(4-fluorophenyl)butoxy)-2,4-dimethyl-6-(2-(piperidin-1-yl)ethoxy)benzo[d]oxazol-5-yl)ethanone Hydrochloride. Grades: 99%. CAS No. 2108780-57-8. Molecular formula: C28H35FN2O4.HCl. Mole weight: 519.05. | |
| Kv1.3 Control Antigen (Kcna3, Charybdotoxin- sensitive Voltage-dependent Potassium Channel, HLK3) | Kv1.3 Control Antigen (Kcna3, Charybdotoxin- sensitive Voltage-dependent Potassium Channel, HLK3). Group: Molecular Biology. Grades: Purified. Pack Sizes: 120ug. US Biological Life Sciences. | Worldwide |
| Kv2.1-IN-1 | Kv2.1-IN-1 (compound 80) is a potent inhibitor of Kv2.1, with the IC 50 value of 0.07 μM, selectivity >130 fold over other K + , Na + , and Ca 2+ ion channels [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2252448-93-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161104. | |
| KVS0001 | KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3056394-59-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161111. | |
| Kw-2449 | KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 1000669-72-6. Molecular formula: C20H20N4O. Mole weight: 332.4. Purity: >99%. Product ID: ACM1000669726. Alfa Chemistry ISO 9001:2015 Certified. | |
| KW-2449 | KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.. Uses: Scientific research. Group: Signaling pathways. CAS No. 1000669-72-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10339. | |
| KW-2449 | KW-2449 is a novel multikinase inhibitor, which suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Recent research showed that HDACIs increase KW-2449 lethality in Bcr/Abl(+) cells in association with inhibition of Bcr/Abl, generation of ROS, and induction of DNA damage. This strategy preferentially targets primary Bcr/Abl(+) hematopoietic cells and exhibits enhanced in vivo activity. Combining KW-2449 with HDACIs warrants attention in IM-resistant Bcr/Abl(+) leukemias. Synonyms: KW2449; KW-2449; KW 2449. CAS No. 1000669-72-6. Molecular formula: C20H20N4O. Mole weight: 332.407. | |
| KW-2450 Tosylate salt | KW-2450 is insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) antagonist. KW-2450 can selectively bind to and inhibit the activities of IGF-1R and IR and this may lead to the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In Apr 2013, Phase-I/II for Breast cancer and Phase-I for Solid tumours were discontinued in USA. Uses: Breast cancer; solid tumours. Synonyms: KW-2450 Tosylate salt; KW 2450 Tosylate salt; KW2450 Tosylate salt; (E)-N-(2-(2-(1H-indazol-3-yl)vinyl)-5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)phenyl)-3-methylthiophene-2-carboxamide 4-methylbenzenesulfonate; 904899-25-8 (free base). Grades: 98%. CAS No. 1360433-93-7. Molecular formula: C35H37N5O6S2. Mole weight: 687.83. | |
| KW-2478 | KW-2478 is an agent that targets the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 antagonist KW-2478 appears to inhibit Hsp90, resulting in impaired signal transduction, inhibition of cell proliferation, and the induction of apoptosis in tumor cells. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses. Synonyms: 2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide; KW 2478; KW2478; QY50S617NM; 2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide; 819812-04-9 (free base); 2-[2-ethyl-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)phenyl]carbonyl-3,5-bis(oxidanyl)phenyl]-~{N},~{N}-bis(2-methoxyethyl)ethanamide. Grades: >98%. CAS No. 819812-04-9. Molecular formula: C30H42N2O9. Mole weight: 574.66. | |
| KW-2478 | KW-2478 is an inhibitor of Hsp90α , with an IC 50 of 3.8 nM, and has antitumor activity against various human hematological tumor cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 819812-04-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13468. | |
| KW 3902 | KW 3902. Group: Biochemicals. Grades: Purified. CAS No. 136199-02-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KW-3902 | KW-3902 is a selective adenosine A1 receptor antagonist under the development of Kyowa Hakko and Merck & Co. It displays 890-fold selectivity for rat A1 receptors over A2A receptors. (Ki value for adenosine A1 is 0.19 nM; 170 nM for adenosine A2A ). KW-3902 exhibits diuretic and renal protective effects in rats. Clinical trials for the treatment of Acute heart failure, Cognition disorders and Hypertension was discontinued. Uses: Acute heart failure; cognition disorders; hypertension. Synonyms: 1,3-dipropyl-8-(3-noradamantyl)xanthine, 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione, KW-3902; KW 3902; KW3902; Rolofylline. Grades: 98%. CAS No. 136199-02-5. Molecular formula: C20H28N4O2. Mole weight: 356.46. | |
| KW-3902 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KW-8232 | KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 217813-15-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100304A. | |
| KW-8232 free base | KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 170365-25-0. Pack Sizes: 1 mg. Product ID: HY-100304. | |
| KWAR 23 | KWAR23 is an anti-human SIRP? antibody. KWAR23 binds human SIRP? with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research[1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2243227-60-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99175. | |
| KWG 1342 | KWG 1342. Group: Biochemicals. Alternative Names: 4-(4-Chlorophenoxy)-2,2-dimethyl-4-(1H-1,2,4-triazol-1-yl)-1,3-butanediol. Grades: Highly Purified. CAS No. 72699-18-4. Pack Sizes: 2.5mg. Molecular Formula: C14H18ClN3O3, Molecular Weight: 311.76. US Biological Life Sciences. | Worldwide |
| KWG 1342 Sulfate Sodium Salt | KWG 1342 Sulfate Sodium Salt. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C14H17ClN3NaO6S, Molecular Weight: 413.81. US Biological Life Sciences. | Worldwide |
| KX1-004 | KX1-004 is an Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect. KX1-004 has been used to protect the cochlea from hazardous noise. Synonyms: KX1-004; KX 1-004; KX1 004. Grades: 0.98. CAS No. 518058-84-9. Molecular formula: C16H13FN2O2. Mole weight: 284.29. | |
| KX1-141 | KX1-141 is an Src-protein tyrosine kinase inhibitor, which may reduce cisplatin ototoxicity while preserving its antitumor effect. Synonyms: KX-1-141; KX 1-141; 1H-Indole-2-carboxamide, 7-(3-ethoxyphenyl)-5-fluoro-N-[(3-fluorophenyl)methyl]-. Grades: 98%. CAS No. 1000706-00-2. Molecular formula: C24H20F2N2O2. Mole weight: 406.42. | |
| KX2-391 | KX2-391 is an orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, Src kinase inhibitor KX2-391 specifically binds to the peptide substrate binding site of Src kinase; inhibition of kinase activity may result in the inhibition of primary tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis. Uses: Enzyme inhibitors. Synonyms: KX01, KX-01, KX 01, KX2-391; KX-2-391; KX 2-391; KX2391; KX-2391; KX 2391; Tirbanibulin. CAS No. 897016-82-9. Molecular formula: C26H29N3O3. Mole weight: 431.53. | |
| KX2-391 dihydrochloride | KX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Synonyms: KX2-391 dihydrochloride; 1038395-65-1; KX2-391 (dihydrochloride); Tirbanibulin (dihydrochloride); N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide;dihydrochloride. Grades: >98%. CAS No. 1038395-65-1. Molecular formula: C26H31Cl2N3O3. Mole weight: 504.45. | |
| KY02111 | KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling. Synonyms: N-(6-chlorobenzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)propanamide. Grades: >98%. CAS No. 1118807-13-8. Molecular formula: C18H17ClN2O3S. Mole weight: 376.86. | |
| KY02111 | KY02111. Group: Biochemicals. Alternative Names: KY 02111, KY-02111, CHEMBL3186128, HY-13815, S-7828. Grades: Highly Purified. CAS No. 1118807-13-8. Pack Sizes: 10mg, 50mg. Molecular Formula: C18 H17 ClN 2O3, Molecular Weight: 376.9. US Biological Life Sciences. | Worldwide |
| KY02111 | KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1118807-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13815. | |
| KY02111 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KY 02111 | KY 02111. Group: Biochemicals. Grades: Purified. CAS No. 1118807-13-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KY 05009 | KY 05009 is an inhibitor of Traf2- and Nck-Interacting Kinase (TNIK; Ki value 100 nM in ATP competitive assay) that attenuates TGF-β1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma A549 cells. In addition, KY05009 inhibits TGF-β1-induced phosphorylation of JNK1/2, FAK, Src, and paxillin. Synonyms: KY 05009; KY05009; KY-05009; 5-(4-methylbenzamido)-2-(phenylamino)thiazole-4-carboxamide; 2-anilino-5-[(4-methylbenzoyl)amino]-1,3-thiazole-4-carboxamide. Grades: 99%. CAS No. 1228280-29-2. Molecular formula: C18H16N4O2S. Mole weight: 352.41. | |
| KY-05009 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KY-05009 | KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. KY-05009 pharmacologically inhibits TGF-?1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228280-29-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124745. | |
| KY-1044 | KY-1044 is a novel anti-inducible co-stimulator molecule (ICOS) subclass G1 kappa monoclonal antibody developed for the treatment of cancer. KY-1044 has a dual mechanism of action: stimulating immune cells which are fighting the tumor, while also killing a type of cell known as T regulatory cells (Tregs). Uses: Potential cancer therapy. Synonyms: KY-1044; KY1044; KY1044. | |
| KY1220 | KY1220 is a novel inhibitor of the Wnt/ß-catenin pathway, destabilizing both β-catenin and Ras via targeting the Wnt/β-catenin pathway (IC50= 2.1 μM in HEK293 reporter cells). Synonyms: KY1220; KY-1220; KY 1220; (5Z)-5-[[1-(4-nitrophenyl)pyrrol-2-yl]methylidene]-2-sulfanylideneimidazolidin-4-one. CAS No. 292168-79-7. Molecular formula: C14H10N4O3S. Mole weight: 314.32. | |
| KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice. Uses: Enzyme inhibitors. Synonyms: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide; BCP32729; EX-A3829. CAS No. 1621673-53-7. Molecular formula: C27H31NO3S2. Mole weight: 481.7. | |
| KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. KY-226 restores Akt (protein kinase B) phosphorylation and extracellular signal-regulated kinase (ERK) reduction in transient middle cerebral artery occlusion (tMCAO) damage. KY-226 protects BBB integrity by restoration of TJ proteins, an effect partly mediated by Akt/FoxO1 pathway activation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KY-226; KY 226; KY226. Product Category: Inhibitors. Appearance: Fluffy white solid powder. CAS No. 1621673-53-7. Molecular formula: C27H31NO3S2. Mole weight: 481.67. Purity: >97%. IUPACName: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide. Canonical SMILES: O=C(NS(=O)(CCCCCC)=O)C1=CC=C(CSCC2=CC=C(C3=CC=CC=C3)C=C2)C=C1. Product ID: ACM1621673537. Alfa Chemistry ISO 9001:2015 Certified. Categories: KY 2265. | |
| KYA1797K | KYA1797K is a potent, selective and dual inhibitor of Wnt/β-catenin (IC50= 0.75 μM) that significantly decreases reporter activities for the Wnt/β-catenin and MAPK/ERK pathways. Synonyms: potassium;3-[(5Z)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoate. Grades: >98%. CAS No. 1956356-56-1. Molecular formula: C17H11KN2O6S2. Mole weight: 442.51. | |
| KYA1797K potassium salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KYL | KYL. Group: Biochemicals. Grades: Purified. CAS No. 676657-00-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KYL | KYL is a selective and potent EphA4 receptor tyrosine kinase antagonist with Kd value of 0.8 μM. It inhibits EphA4-EphrinA5 interactions with IC50 value of 6.34 μM. It prevents AβO induced dendritic spine loss and synaptic damage. It also prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. It shows a long half life in cell culture media. It has the neuroprotective effect. Synonyms: H-Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu-OH; L-lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-L-leucine; HY-P2264. Grades: ≥95%. CAS No. 676657-00-4. Molecular formula: C74H108N14O17. Mole weight: 1465.75. | |
| KYL acetate | KYL is a selective and potent EphA4 receptor tyrosine kinase antagonist with a Kd value of 0.8 μM. It inhibits EphA4-EphrinA5 interactions with an IC50 value of 6.34 μM. It prevents AβO induced dendritic spine loss and synaptic damage. It also prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. It shows a long half-life in cell culture media. It has a neuroprotective effect. Synonyms: L-Leucine, L-lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-, acetate; L-Lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-L-leucine acetate; KYL peptide acetate; Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu acetate salt. Grades: ≥95%. Molecular formula: C74H108N14O17.C2H4O2. Mole weight: 1525.78. | |
| KYL trifluoroacetate salt | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Kyn1-(Des-Trp1) Daptomycin | Kyn1-(Des-Trp1) Daptomycin is a derivative of Daptomycin (D193350), is a cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C71H101N17O27, Molecular Weight: 1624.66. US Biological Life Sciences. | Worldwide |
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