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| Product | Description | |
|---|---|---|
| KP372-1 | KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an NQO1 redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1374996-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15673. |  |
| KP372-1 | KP372-1 is a synthetic small molecule AKT inhibitor. KP372-1 is consisted of two isomers: KP372-1A and KP372-1B. KP372-1 showed activities to block signalling downstream of Akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis. KP372-1 has also been shown to suppress cell proliferation and induce apoptosis in gliobastoma. Synonyms: KP 372-1; indeno[2,3-e]1,2,3,4-tetraazolo[1,5-b]1,2,4-triazin-10-one; 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one. CAS No. 329710-24-9. Molecular formula: C10H4N6O. Mole weight: 224.18. |  |
| KP-457 | KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1365803-52-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110397. | |
| KP496 | KP496, a novel dual antagonist of cysLT receptor and TP, is currently in clinical development as a dry powder inhaler. KP496 inhibited epithelial hypertrophy and increased mucus production in asthmatic animals. Synonyms: KP496; KP 496; KP-496; 2- [4- [ (4-chlorophenyl) sulfonylamino] butyl- [ [3- [ (4-propan-2-yl-1, 3-thiazol-2-yl) methoxy] phenyl] methyl] sulfamoyl] benzoic acid. CAS No. 217799-03-6. Molecular formula: C31H34ClN3O7S3. Mole weight: 692.27. | |
| Kp7-6 | Kp7-6, a Fas mimetic peptide, is a Fas/FasL antagonist. Kp7-6 protects cells from Fas-mediated apoptosis, and protects mice from Fas-mediated hepatic injury[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 629628-53-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10102. | |
| KPI-10 | KPI-10, also known as WQ3810, is a new compound currently being studied for its efficacy in the treatment of infections caused by multidrug-resistant bacteria. WQ-3810 demonstrated high potent activity against the antimicrobial-resistant pathogens tested. WQ-3810 (MIC(90)=4 mg/L and 0.06 mg/L, respectively) was also more active than ciprofloxacin (64 mg/L and 2 mg/L) and levofloxacin (32 mg/L and 2 mg/L). Furthermore, WQ-3810 was the most potent among the fluoroquinolones tested against meticillin-resistant Staphylococcus aureus (MRSA) and Neisseria gonorrhoeae, including FQR isolates. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KPI-10; KPI10; KPI 10; WQ3810; WQ-3810; WQ 3810. Product Category: Others. Appearance: Solid powder. CAS No. 888032-58-4. Molecular formula: C22H22F3N5O3. Mole weight: 461.45. Purity: >98%. IUPACName: 1-(6-Amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-(isopropylamino)azetidin-1-yl)-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Canonical SMILES: O=C(C1=CN(C2=NC(N)=C(F)C=C2F)C3=C(C=C(F)C(N4CC(NC(C)C)C4)=C3C)C1=O)O. Product ID: ACM888032584. Alfa Chemistry ISO 9001:2015 Certified. Categories: KPS 10721. |  |
| KPM-2 | KPM-2 is an inhibitor of sirtuin-2 (SIRT2), an NAD-dependent protein deacetylase, which is thought to be involved in cancer progression and in neurodegeneration. It shows antiproliferative activity in cancer cells and inhibits neurite growth. KMP-2 is hopefully used for the treatment of cancer progression and neurodegenerative disorders. Uses: The potential treatment of cancer. Synonyms: KPM-2; KPM 2; KPM2. | |
| Kpn I | One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. GGTAC↑C C↓CATGG. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer B, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Kpn I gene from Klebsiella pneumonia. Pack: 10 mM Tris-HCl(pH 7.5); 50 mM NaCl; 0,1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1125RE. |  |
| KPT185 | KPT185. Group: Biochemicals. Alternative Names: (2Z) -3-[3-[3-Methoxy-5- (trifluoromethyl) phenyl]-1H-1, 2, 4-triazol-1-yl]-2-Propenoic Acid 1-Methylethyl Ester. Grades: Highly Purified. CAS No. 1333151-73-7. Pack Sizes: 10mg. Molecular Formula: C16H16F3N3O3, Molecular Weight: 355.31. US Biological Life Sciences. |  Worldwide |
| KPT-185 | KPT-185 is an orally bioavailable and selective inhibitor of CRM1 and displays potent antiproliferative properties at submicromolar concentrations ( IC 50 =100-500 nM), induces apoptosis, cell-cycle arrest, and myeloid differentiation in AML cell lines and patient blasts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1333151-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15611. | |
| KPT 251 | KPT 251. Group: Biochemicals. Alternative Names: (Z) -2- (2- (3- (3, 5-Bis (trifluoromethyl) phenyl) -1H-1, 2, 4-triazol-1-yl) vinyl) -1, 3, 4-oxadiazole. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Kpt-330, (E)- | Cas No. 1421923-86-5. | |
| KPT 330 Hydrochloride | KPT 330 Hydrochloride, is a chromosome maintenance protein 1 (CRM1) inhibitor. KPT 330 suppresses downstream effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C17H11F6N7O; HCl, Molecular Weight: 443.313646. US Biological Life Sciences. | Worldwide |
| KPT-6566 | KPT-6566 is a selective and covalent prolyl isomerase PIN1 inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades PIN1. KPT-6566 shows an IC50 value of 640 nM and a Ki value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 881487-77-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123847. | |
| KPT9274 | KPT9274 Inhibitor. Uses: Scientific use. Product Category: T4354. CAS No. 1643913-93-2. |  |
| KPU-300 | KPU-300, a diketopiperazine derivative, has been found to be an antimicrotubule agent and exhibit cytotoxicity against HT-29 cells. IC50: 7.0 nM. Synonyms: KPU-300; KPU 300; KPU300; (E)-3-((E)-3-benzoylbenzylidene)-6-(pyridin-2-ylmethylene)piperazine-2,5-dione. Grades: 98%. CAS No. 1620692-60-5. Molecular formula: C24H17N3O3. Mole weight: 395.42. | |
| KR-12 | KR-12 is an antibacterial peptide. It has activity against gram-positive bacteria and gram-negative bacteria. Synonyms: KR-12 (human); Antibacterial Protein LL-37 amide (human) (18-29); H-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-NH2. Grades: 95.6%. CAS No. 1218951-51-9. Molecular formula: C71H127N25O15. Mole weight: 1570.9. | |
| KR30031 | KR30031 is a novel P-glycoprotein inhibitor with potential anticancer activity. KR30031 is a verapamil analog with fewer cardiovascular effects. The ability of KR-30031 to reduce this efflux transport is equal to that of verapamil, a well-known P-glycoprotein inhibitor. The bioavailability of paclitaxel could be enhanced by coadministration of a P-glycoprotein inhibitor, KR-30031. Synonyms: KR-30031; KR 30031; 1- (3- ( (3, 4-dimethoxyphenethyl) (methyl)amino)propyl)-4, 5-dimethoxy-2, 3-dihydro-1H-indene-1-carbonitrile. Grades: 98%. CAS No. 205535-74-6. Molecular formula: C26H34N2O4. Mole weight: 438.56. | |
| KR-32568 | KR-32568 is a sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor (IC50 = 230 nM). KR-32568 inhibited NHE-1-mediated rabbit platelet swelling induced by intracellular acidification. It reduced myocardial infarct size in an anesthetized rat model. Synonyms: [5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine. Grades: ≥98%. CAS No. 852146-73-7. Molecular formula: C13H12FN3O2. Mole weight: 261.3. | |
| KR-32568 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Kras4B G12D-IN-1 | Kras4B G12D-IN-1 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2042365-85-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153413. | |
| K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629265-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18604. | |
| K-Ras G12C-IN-1 | K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-1. Grades: >98%. CAS No. 1629265-17-3. Molecular formula: C22H23Cl2N3O3. Mole weight: 448.34. | |
| K-Ras G12C-IN-2 | K-Ras G12C-IN-2 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-2. Grades: >98%. CAS No. 1629267-75-9. Molecular formula: C21H27ClN4O3. Mole weight: 418.92. | |
| K-Ras G12C-IN-3 | K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C. Synonyms: K-Ras G12C-IN-3. Grades: >98%. CAS No. 1629268-19-4. Molecular formula: C21H19Cl3N2O3. Mole weight: 453.75. | |
| K-Ras G12C-IN-4 | K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRAS G12C [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376328-55-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128771. | |
| K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor. K-Ras(G12C) inhibitor 12 acts on H1792 cells with an EC50 of 0.32 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-95-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18707. | |
| K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). Synonyms: MDK-7958; MDK7958; MDK 7958; K-Ras(G12C) inhibitor 12. Grades: >98%. CAS No. 1469337-95-8. Molecular formula: C15H17ClIN3O3. Mole weight: 449.67. | |
| KRAS G12C inhibitor 14 | KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC 50 of 18 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2349393-95-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125872. | |
| K-Ras(G12C) inhibitor 6 | K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2060530-16-5. Pack Sizes: 2 mg. Product ID: HY-107841. | |
| K-Ras(G12C) inhibitor 9 | K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). Synonyms: K-RAS inhibitor 9; N-(1-{2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl}piperidin-4-yl)ethene-1-sulfonamide. Grades: >98%. CAS No. 1469337-91-4. Molecular formula: C16H21ClIN3O4S. Mole weight: 513.78. | |
| K-Ras(G12C) inhibitor 9 | K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1469337-91-4. Pack Sizes: 2 mg. Product ID: HY-12446. | |
| K-Ras-IN-1 | K-Ras-IN-1 is a K-Ras inhibitor. It binds to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. Synonyms: MDK-3017; MDK3017; MDK 3017; K-Ras-IN-2; K-Ras Inhibitor-2. 1-(2-Hydroxythiobenzoyl)pyrrolidine;6-[pyrrolidin-1-yl(sulfanyl)methylidene]cyclohexa-2,4-dien-1-one. Grades: >98%. CAS No. 84783-01-7. Molecular formula: C11H13NOS. Mole weight: 207.29. | |
| KRC-108 | KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumor growth in human HT29 colorectal cancer and NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice. This molecule should serve as a useful lead for inhibitors targeting kinases and may lead to new therapeutics for the treatment of cancer. Synonyms: KRC 108; KRC108; 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine. CAS No. 1146944-35-5. Molecular formula: C20H20N6O. Mole weight: 360.41. | |
| KRCA 0008 | KRCA 0008. Group: Biochemicals. Grades: Purified. CAS No. 1472795-20-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KRCA-0008 | Potent and selective dual ALK (anaplastic lymphoma kinase ) and ACK1 inhibitor (IC50 values 12 nM and 4 nM for ALK and Ack1, respectively) with good drug-like properties: good water-solubility with moderate plasma protein binding and low brain exposure. It has good liver microsomal stability and little to no CYP inhibition. KRCA0008 also shows promising pharmacokinetic parameters in both mice and rat (oral bioavailability=66-94.5%) and a modest tumor growth inhibition in vivo activity in H3122 human lung cancer bearing mice model comparable to Crizotinib without significant body weight change. Synonyms: KRCA-0008; KRCA 0008; KRCA0008. Grades: >98%. CAS No. 1472795-20-2. Molecular formula: C30H37ClN8O4. Mole weight: 609.12. | |
| KRCA-0008 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Kresoxim-methyl | An agricultural fungicide. Group: Biochemicals. Alternative Names: (α E) -α - (methoxyimino) -2-[ (2-methylphenoxy) methyl]benzeneacetic acid methyl ester; BAS 490-02F; BAS 490F; Candit; Cygnus; Discus; Discus (fungicide); RIL-FA 200; Strob 1; Stroby; Stroby WG. Grades: Highly Purified. CAS No. 143390-89-0. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Kresoxim-methyl | Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent K d of 0.07 μM proving a high affinity for this enzyme [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAS 490 F. CAS No. 143390-89-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-125776. | |
| Kresoxim-methyl-d7 | Kresoxim-methyl-d7. Group: Biochemicals. Alternative Names: (α E) -α - (methoxyimino) -2-[ (2-methylphenoxy) methyl]benzeneacetic Acid Methyl Ester-d7; BAS 490-02F-d7; BAS 490F-d7; Candit-d7; Cygnus-d7; Discus-d7; Discus (fungicide)-d7; RIL-FA 200-d7; Strob 1-d7; Stroby-d7; Stroby WG-d7. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C18H12D7NO4, Molecular Weight: 320.39. US Biological Life Sciences. | Worldwide |
| Kresoxim-methyl Impurity 4 | Kresoxim-methyl Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 141517-21-7. Molecular formula: C20H19F3N2O4. Mole weight: 408.38. Catalog: APB141517217. | |
| Kreysigine | (-)-Kreysigine is an alkaloid originally isolated from B. vernum. Synonyms: (-)-Kreysigine. Grades: >95% by HPLC. CAS No. 23117-57-9. Molecular formula: C22H27NO5. Mole weight: 385.45. | |
| KRFK TFA | KRFK TFA, a peptide derived from TSP-1, can activate TGF-?. KRFK TFA promotes TGF-?-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach[1]. Uses: Scientific research. Group: Peptides. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3970A. | |
| KRH1636 | KRH1636 is an orally active, selective and extremely potent CXC chemokine receptor 4(CXCR4) antagonist. It exhibits a potent and selective anti-HIV-1 activity. It efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXCR4 coreceptor. It also inhibits binding of the CXC chemokine, stromal cell-derived factor 1alpha, to CXCR4 specifically and subsequent signal transduction. It prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor. It seems to be a promising agent for the treatment of HIV-1 infection. Uses: Krh1636 seems to be a promising agent for the treatment of hiv-1 infection. Synonyms: KRH-1636; KRH 1636; KRH1636. N-[(2S)-5-(diaminomethylideneamino)-1-[[(1S)-1-naphthalen-1-ylethyl]amino]-1-oxopentan-2-yl]-4-[[methyl(pyridin-2-yl)amino]methyl]benzamide;KRH-1636;N-((S)-5-guanidino-1-(((S)-1-(naphthalen-1-yl)ethyl)amino)-1-oxopentan-2-yl)-4-(((pyridin-2-ylmethyl)amino. Grades: 98%. CAS No. 568526-77-2. Molecular formula: C32H37N7O2. Mole weight: 551.70. | |
| KRH3955 | KRH3955 is a novel CXCR4 antagonist. It is an orally bioavailable compound. It inhibits SDF-1alpha-mediated chemotaxis and HIV-1 infection. Uses: Krh3955 inhibits sdf-1alpha-mediated chemotaxis and hiv-1 infection. Synonyms: KRH-3955; KRH 3955; KRH3955; KRH3955 Salt;N1-(4-((((1H-imidazol-2-yl)methyl)((1-methyl-1H-imidazol-2-yl)methyl)amino)methyl)benzyl)-N1-methyl-N4,N4-dipropylbutane-1,4-diamine tris((2R,3R)-2,3-dihydroxysuccinate);2,3-Dihydroxybutanedioic acid N-[[4-[[1H-imidazol-2-ylmethyl-[ (1-methylimidazol-2-yl) methyl]amino]methyl]phenyl]methyl]-N-methyl-N', N'-dipropylbutane-1, 4-diamine. Grades: >98%. CAS No. 1097732-62-1. Molecular formula: C40H63N7O18. Mole weight: 929.97. | |
| KRIBB11 | KRIBB11 is a heat shock factor (HSF) inhibitor (IC50 = 1.2 μM). KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. In vivo, administration of KRIBB11 decreases tumor growth in a mouse HCT116 xenograft model. Synonyms: N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine; KRIBB11; KRIBB-11; KRIBB 11. CAS No. 342639-96-7. Molecular formula: C13H12N6O2. Mole weight: 284.27. | |
| KRIBB11 | KRIBB11. Group: Biochemicals. Grades: Purified. CAS No. 342639-96-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KRIBB11 | KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC50 of 1.2 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 342639-96-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100872. | |
| KRIBB11 trifluoroacetate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KRIBB3 | KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27. Synonyms: KRIBB-3; KRIBB 3; (6Z)-4-ethyl-3-methoxy-6-[4-(4-methoxyphenyl)-2H-1,2-oxazol-5-ylidene]cyclohexa-2,4-dien-1-one. Grades: 98%. CAS No. 129414-88-6. Molecular formula: C19H19NO4. Mole weight: 325.36. | |
| Krill oil | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| KRM-III | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KRN383 | KRN383 is a novel Flt3 inhibitor with potential anticancer activity. KRN383 inhibited the autophosphorylation of Flt3 bearing internal tandem duplications (ITDs) and the Asp835Tyr (D835Y) point mutation with half-maximal inhibitory concentration (IC(50)) values of < or =5.9 and 43 nM, respectively. KRN383 also inhibited the proliferation of the ITD-positive cell lines with IC(50) values of < or =2.9 nM. A single oral administration of 80 mg/kg of KRN383 eradicated ITD-positive xenograft tumors in nude mice and prolonged the survival of SCID mice carrying ITD-positive AML cells. The effectiveness of a single oral dose of KRN383 suggests that it has the potential to be used in a wide variety of clinical regimens, including multicycle and combination therapies. Synonyms: KRN 383; KRN-383. CAS No. 919767-02-5. Molecular formula: C17H17N3O4. Mole weight: 327.34. | |
| KRN4884 | KRN4884, a synthesized 3-pyridine derivative, shows a long-lasting antihypertensive effect based on its potent potassium channel-opening action. The long-lasting action may be due to a slow association/dissociation with/from the binding sites on vascular smooth muscle. Synonyms: 5-amino-N'-[2-(2-chlorophenyl)ethyl]-N-cyanopyridine-3-carboximidamide; 5-amino-N-(2-(2-chlorophenyl)ethyl)-N'-cyano-3-pyridinecarboxamidine; KRN 4884; KRN-4884; KRN4884. CAS No. 152802-84-1. Molecular formula: C15H14ClN5. Mole weight: 299.76. | |
| KRN5500 | KRN5500 is a semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus. KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions. This agent also induces cell differentiation and caspase-dependent apoptosis. Synonyms: KRN-5500; KRN 5500; SPK-241; SPK241; SPK 241; NSC-650426; 4-Deoxy-N- (7H-purin-6-yl) -4- ( ( (2, 4-tetradecadienoylamino) acetyl) amino) heptopyranosylamine. CAS No. 151276-95-8. Molecular formula: C28H43N7O7. Mole weight: 589.69. | |
| KRN633 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KRN633 | KRN633 is a potent and selective VEGFR inhibitor. which inhibits tyrosine phosphorylation of VEGFR-2 (IC50 = 1.16 nmol/L) in human umbilical vein endothelial cells. Selectivity profiling with recombinant tyrosine kinases showed that KRN633 is highly selective for VEGFR-1, -2, and -3. KRN633 inhibits tumor growth in several in vivo tumor xenograft models with diverse tissue origins, including lung, colon, and prostate, in athymic mice and rats. KRN633 also causes the regression of some well-established tumors and those that had regrown after the cessation of treatment. KRN633 was well tolerated and had no significant effects on body weight or the general health of the animals. KRN633 might be useful in the treatment of solid tumors and other diseases that depend on pathologic angiogenesis. Synonyms: KRN633; KRN-633; KRN 633. Grades: 0.98. CAS No. 286370-15-8. Molecular formula: C20H21ClN4O4. Mole weight: 416.86. | |
| KRN7000 | KRN7000 is a synthetic analog of α-galactosylceramide and the marine natural product agelasphin. It is a specific ligand for human and mouse NKT cells and remains the best studied ligand of the lipid-binding MHC class I-like protein CD1d. It protects against LPS-induced shock and displays potent antitumor activity in various in vivo models. Synonyms: a-Gal-Cer N-[(1S,2S,3R)-1-[(a-D-Galactopyranosyloxy)methyl]-2,3-dihydroxyheptadecyl]hexacosanamide KRN7000. Grades: >99%. CAS No. 158021-47-7. Molecular formula: C50H99NO9. Mole weight: 858.32. | |
| Kroll's Reagent | Excellent for titanium and alloys. Group: Etchants. |  |
| KRP-203 | KRP-203. Group: Biochemicals. Alternative Names: 2-Amino-2- [2- [2-chloro-4- [ [3- (phenylmethoxy) phenyl] thio] phenyl] ethyl] -1, 3-propanediol hydrochloride. Grades: Highly Purified. CAS No. 509088-69-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C24H27Cl2NO3S. US Biological Life Sciences. | Worldwide |
| KRP-203 | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and immune responses. Activation of sphingosine kinase by a variety of agonists increases intracellular S1P, which in turn can function intracellularly as a second messenger or be secreted out of the cell and act extracellularly by signaling through S1P (S1P1-5) receptors. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and an ED50 value >1 μM for the S1P3 receptor. Synonyms: Mocravimod hydrochloride; 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride; 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3- (phenylmethoxy) phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1). Grades: ≥98%. CAS No. 509088-69-1. Molecular formula: C24H27Cl2NO3S. Mole weight: 480.45. | |
| KRP297 | KRP297, also called as L4 10198 or MK 767, is a Peroxisome proliferator-activated receptor (PPAR) alpha and gamma (PPARα and PPARγ) agonist. With potential to treat type 2 diabetes and dyslipidemia, KRP297 is able to decrease plasma glucose and insulin levels. Synonyms: 5-[ (2, 4-dioxo-1, 3-thiazolidin-5-yl) methyl]-2-methoxy-N-[[4- (trifluoromethyl) phenyl]methyl]benzamide; KCL1998001079; KRP 297; KRP-297; KRP297; L 410198; L-410198; L410198; MK 767; MK-767; MK767. Grades: >98%. CAS No. 213252-19-8. Molecular formula: C20H17F3N2O4S. Mole weight: 438.42. | |
| KRpep-2d | KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research [1]. Uses: Scientific research. Group: Peptides. CAS No. 2098181-84-9. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P3277. | |
| KRpep-2d | KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide that has the potential as the treatment of cancers expressing K-Ras(G12C) mutant. Synonyms: s8499. Molecular formula: C108H182N44O25S2. Mole weight: 2561.01. | |
| KRX-0402 | KRX-0402 (O6-benzyl guanine or O6-BG) is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin's lymphoma. Recent research has shown that KRX-0402 can also potentiate the activity of other alkylating agents, such as cyclophosphamide, ifosphamide, cisplatinum and carboplatinum. These drugs are some of the most widely used chemotherapy drugs and are commonly used to treat breast cancer, non-small cell lung cancer and ovarian cancer. Accordingly, It is believed that KRX-0402 may have an important role in making cells more susceptible to the damaging effects of alkylating agents, and that KRX-0402 may have utility in the treatment of multiple forms of cancer. KRX-0402 is administered intravenously. To date, approximately 400 patients have received KRX-0402 in multiple clinical studies. Dose limiting toxicity for KRX-0402 in combination with chemotherapy was bone marrow suppression. KRX-0402 alone has no identified dose limiting toxicity. Two company-sponsored, Phase II clinical trials for KRX-0402 are ongoing. Uses: Enzyme inhibitors. Synonyms: KRX 0402; KRX0402; 6-O-Benzylguanine; 6-(Benzyloxy)-7H-purin-2-amine; O(6)-Benzylguanine; 2-Amino-6-(benzyloxy)purine; NSC-637037; O6-BG. CAS No. 1000874-21-4. Molecular formula: C12H11N5O. Mole weight: 241.254. | |
| Kryptofix 22 dd | Kryptofix 22 dd. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Kryptofix 22dd, Kryptofix 22 DD, 36760_ALDRICH, 36760_FLUKA, MolPort-003-931-086, CID72806, EINECS 279-168-4, NSC339326, NSC 339326, NCGC00166067-01, 1,10-Didecyl-1,10-diaza-18-crown-6, 7,16-Didecyl-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane, 7,16-Didecyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane, 1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane, 7,16-didecyl-, 79495-97-9. Product Category: Heterocyclic Organic Compound. CAS No. 79495-97-9. Molecular formula: C32H66N2O4. Mole weight: 542.88. Purity: 0.96. IUPACName: 7,16-didecyl-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane. Canonical SMILES: CCCCCCCCCCN1CCOCCOCCN(CCOCCOCC1)CCCCCCCCCC. Density: 0.897g/cm³. ECNumber: 279-168-4. Product ID: ACM79495979. Alfa Chemistry ISO 9001:2015 Certified. | |
| Kryptofix(r) 211 | Kryptofix(r) 211. Uses: Designed for use in research and industrial production. Additional or Alternative Names: cryptating agent 211. Product Category: Other Monomers. CAS No. 31250-06-3. Molecular formula: C14H28N2O4. Mole weight: 288.38 g/mol. Product ID: ACM-MO-31250063. Alfa Chemistry ISO 9001:2015 Certified. Categories: 4,7,13,18-tetraoxa-1,10-diazabicyclo[8.5.5]icosane. | |
| KS100 | KS100 is a potent ALDH inhibitor with IC 50 s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408477-54-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146682. | |
| KS15 | KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer. KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4.9 ?M) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock. Anti-proliferative activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1033781-20-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115672. | |
| KS176 | KS176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of ATP-binding cassette sub-family G member 2. IC50: 1.39 μM. Uses: Ks176 is a breast cancer resistance protein inhibitor and also exhibits some extent of inhibition of atp-binding cassette sub-family g member 2. Synonyms: KS-176; KS176; KS 176. ZINC86032128; AKOS024458013; CS-5435; HY-19753; CS 5435; HY 19753; CS5435; HY19753. Grades: 98%. CAS No. 1253452-78-6. Molecular formula: C22H19N3O5. Mole weight: 405.40. | |
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