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| Product | Description | |
|---|---|---|
| Kisspeptin-54 (27-54) (human) | Kisspeptin-54 (27-54) (human) is an LRF-amide motif containing a fragment of malignant melanoma metastasis-suppressor KiSS-1, that binds to human GPR54, a G-protein-coupled receptor. Compared with malignant melanoma metastasis-suppressor Kisspeptin-10, it shows lower agonistic potency to AXOR12. Synonyms: KiSS-1 (94-121) (human); H-Ile-Pro-Ala-Pro-Gln-Gly-Ala-Val-Leu-Val-Gln-Arg-Glu-Lys-Asp-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2; L-isoleucyl-L-prolyl-L-alanyl-L-prolyl-L-glutaminyl-glycyl-L-alanyl-L-valyl-L-leucyl-L-valyl-L-glutaminyl-L-arginyl-L-alpha-glutamyl-L-lysyl-L-alpha-aspartyl-L-leucyl-L-prolyl-L-asparagyl-L-tyrosyl-L-asparagyl-L-tryptophyl-L-asparagyl-L-seryl-L-phenylalanyl-glycyl-L-leucyl-L-arginyl-L-phenylalaninamide; Metastin (27-54) (human); Malignant melanoma metastasis-Suppressor KiSS-1 (94-121) (human). Grades: ≥95% by HPLC. CAS No. 1135442-77-1. Molecular formula: C149H226N42O39. Mole weight: 3229.65. |  |
| Kisspeptin-54(human) | Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with K i values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Peptides. Alternative Names: Metastin(human). CAS No. 374683-24-6. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-P1022. |  |
| Kisspeptin-54 (human) trifluoroacetate salt | Kisspeptin-54 is an endogenous ligand for the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors respectively). It was shown to stimulate the hypothalamic-pituitary-gonadal (HPG) axis in animal models and humans. Synonyms: Metastin (human). Grades: ≥95%. Molecular formula: C258H401N79O78·xCF3COOH. Mole weight: 5857.43. | |
| Kistamicin A | Kistamicin A is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 3.6 and 44. It also has anti-gram-positive bacterial effects. Synonyms: Kistamycin A. CAS No. 155683-50-4. Molecular formula: C61H51ClN8O15. Mole weight: 1171.55. | |
| Kistamicin B | Kistamicin B is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 1.8 and 30. Synonyms: Kistamycin B. CAS No. 155683-51-5. Molecular formula: C70H60ClN9O16. Mole weight: 1318.73. | |
| KIT-6 | KIT-6. Group: Kit-6. CAS No. 12173-28-3. Pack Sizes: 10 g. |  |
| Kitamycin A | It is originally isolated from Strptomyces sp. K385. Kitamycin A can inhibit the activity of plant growth. Molecular formula: C23H32N2O8. Mole weight: 464.51. | |
| Kit for Creating Hydrophilic PDMS Surface | Kit for Creating Hydrophilic PDMS Surface. Group: Self assembly and lithography. | |
| Kiwifruit concentrate powder | Kiwifruit concentrate powder contains a naturally potent proteolytic enzyme, actinidin, which enhances protein digestion. In-vitro studies have shown that actinidin enhances the digestion of a number of different food proteins, including soy, red meat, milk, gluten and gliaden. Kiwifruit concentrate powder may also help to improve gut motility, which is an important contributor to improved bowel function. The active enzyme content of Kiwifruit concentrate powder is protected by specialised pre-processing and freeze drying techniques which maintain optimal temperature and pH conditions. Group: Others. Activity: >20,000 u/g. Appearance: green to brown powder. Form: Freeze dried powder. Source: green kiwifruit. Actinidin; Kiwifruit concentrate powder; Kiwifruit powder. Cat No: KCP-001. |  |
| Kiwi Powder | Kiwi fruit powder is made from fresh kiwi (Actinidia Chinensis), adopt the advanced spray drying technology. Kiwi juice powder is a rich source of vitamin C and vitamin A. Kiwi fruit powder can be used for drinks, health care products, baby food, puffed food, baking food, ice cream, and oatmeal. Group: Others. Kiwi Powder; Actinidia chinensis. Cat No: EXTC-083. | |
| Kjeldahl Nitrogen, Total (TKN) - WS | Proficiency Testing Material. Group: Atomic absorption spectroscopy (aas). |  |
| KJ Pyr 9 | KJ Pyr 9 is a cell-permeable inhibitor of c-Myc (Kd = 6.5 nM) that disrupts Myc-Max interaction. Uses: Disrupts myc-max interaction. Synonyms: KJ-Pyr-9; KJPyr-9; KJ Pyr-9; KJ-Pyr9; KJPyr9; KJ Pyr9; 4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide. Grades: ≥98%. CAS No. 581073-80-5. Molecular formula: C22H15N3O4. Mole weight: 385.4. | |
| KJ Pyr 9 | KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay. Uses: Scientific research. Group: Signaling pathways. CAS No. 581073-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19735. | |
| KKII5 | KKII5 is a potent Lipoxygenase ( LOX-1 ) inhibitor with an IC 50 of 19 μM. KKII5 inhibits lipid peroxidation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 6381-55-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W488004. | |
| KKL-10 | KKL-10 is a small-molecule ribosome rescue inhibitor with exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis in vitro and during ex vivo infection. Synonyms: KKL-10; KKL 10; KKL10. 5-bromo-N-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide; 5-bromo-N-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)thiophene-2-carboxamide; 5-bromo-N-[5-(p-tolyl)-1,3,4-oxadiazol-2-yl]thiophene-2-carboxamide. CAS No. 952849-76-2. Molecular formula: C14H10BrN3O2S. Mole weight: 364.22. | |
| KKL-35 | KKL-35 is a trans-translation tagging reaction inhibitor (IC50= 0.9 μM), thereby inhibiting bacterial growth by blocking ribosome rescue. Synonyms: KKL-35; KKL 35; KKL35; 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide; F1374-0110; 4-chloro-N-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)benzamide. CAS No. 865285-29-6. Molecular formula: C15H9ClFN3O2. Mole weight: 317.7. | |
| KKL-35 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KKL-40 | KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 865285-47-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116863. | |
| KL001 | KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 309928-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108468. | |
| KL001 | KL001. Group: Biochemicals. Alternative Names: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide. Grades: Highly Purified. CAS No. 309928-48-1. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C21H22N2O4S, Molecular Weight: 398.48. US Biological Life Sciences. |  Worldwide |
| KL001 | KL001 is a small molecule that specifically interacts with cryptochrome (CRY), blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Uses: Cryptochrome protein (cry) stabilizer. Synonyms: KL 001; KL-001; N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide. Grades: ≥98%. CAS No. 309928-48-1. Molecular formula: C21H22N2O4S. Mole weight: 398.48. | |
| KL001 | KL001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In combination with mathematical modeling, our studies using KL001 revealed that CRY1 and CRY2 share a similar functional role in the period regulation. Furthermore, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KL001; KL-001; KL 001. Product Category: Others. Appearance: Solid powder. CAS No. 309928-48-1. Molecular formula: C21H22N2O4S. Mole weight: 398.48. Purity: >98%. IUPACName: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide. Canonical SMILES: CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O. Product ID: ACM309928481. Alfa Chemistry ISO 9001:2015 Certified. Categories: Kl2017. |  |
| KL001 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KL 001 | KL 001. Group: Biochemicals. Grades: Purified. CAS No. 309928-48-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KL002 | KL002. Group: Biochemicals. Alternative Names: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-iodophenyl)-methanesulfonamide. Grades: Highly Purified. CAS No. 439141-72-7. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C22H21IN2O3S, Molecular Weight: 520.38. US Biological Life Sciences. | Worldwide |
| KL-11743 | KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1369452-53-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145597. | |
| KL-11743 | KL-11743 is a potent, orally active and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90 and 68 nM for GLUT1, GLUT2, GLUT3 and GLUT4, respectively. It specifically blocks glucose metabolism and induces cell death in concert with electron transport inhibitors. Synonyms: NSC783733; Acetamide, 2-[3-[6-ethoxy-4-[[4-(1H-pyrazol-4-yl)phenyl]amino]-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-. Grades: ≥98%. CAS No. 1369452-53-8. Molecular formula: C30H30N6O3. Mole weight: 522.60. | |
| KL1333 | KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1800405-30-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128895. | |
| KL-50 | KL-50 is a selective toxin toward tumors that lack the DNA repair protein O 6 -methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O 6 -alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1161826-19-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164496. | |
| KLD12 | KLD12, a hydrogel obtained from the self-assembled peptide, regulates in vitro chondrogenesis of bovine bone marrow stromal cells. Synonyms: Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2; N-acetyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucinamide; L-Leucinamide, N2-acetyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-. Grades: ≥95% by HPLC. CAS No. 800379-47-9. Molecular formula: C68H122N16O19. Mole weight: 1467.79. | |
| Kleermount, in Xylene, Laboratory Grade, 100 mL | Kleermount®, in Xylene, Laboratory Grade, 100 mL - A permanent neutral mounting medium that will not turn acid or darken with age. Storage Code: Red; flammable. DOT Class: Flammable. Grades: chem-grade laboratory. Product ID: 871343. -- SOLD FOR EDUCATIONAL USE ONLY -- |  |
| Klemm's No.2 Reagent | Stain or tint etch for etching cast iron, copper and tin. Group: Etchants. | |
| Klemm's Reagent | For etching alpha-beta brass, bonze, tin, cast iron phosphides, ferrite, martensite, retained austenite, zinc and steel temper embrittlement. Group: Etchants. | |
| KLF4-TAT human | recombinant, expressed in HEK 293 cells, ?90% (SDS-PAGE), ?90% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| KLF5 Inhibitor, CID 5951923 (2- ( (1, 1-Dioxidotetra hydrothiophen-3-yl, methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate) | A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50=1.6uM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182. Group: Biochemicals. Grades: Highly Purified. CAS No. 749872-43-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| KLH45 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KLH 45 | KLH 45 is a selective, potent and irreversible inhibitor of DDHD domain containing 2 (DDHD2) with IC50 value of 1.3 nM. It is selective for DDHD2 over 40 other serine hydrolases. It shows cross-reactivity with ABHD6. It is active in vivo and increases brain triacylglycerol levels in mouse brain. Synonyms: KLH45; KLH-45; KLH 45; N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 1632236-44-2. Molecular formula: C24H25F3N4O2. Mole weight: 458.48. | |
| Klotho human | recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| KLS-13019 | KLS-13019, an azetidine derivative, could be a neuroprotective agent and has been found to exbihit much more effective than cannabidiol. Synonyms: KLS-13019; KLS 13019; KLS13019; 1-(3-(((1'R,2'R)-2,6-dihydroxy-5'-methyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro-[1,1'-biphenyl]-4-yl)methyl)azetidin-1-yl)ethan-1-one. Grades: 98%. CAS No. 1801243-39-9. Molecular formula: C22H29NO3. Mole weight: 355.48. | |
| KM04416 | KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 26530-26-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148685. | |
| KM11060 | KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein. Synonyms: KM11060; KM-11060; KM 11060. Grades: 98%. CAS No. 774549-97-2. Molecular formula: C19H17Cl2N3O2S. Mole weight: 422.324. | |
| KM 11060 | KM 11060. Group: Biochemicals. Grades: Purified. CAS No. 774549-97-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KM91104 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KM 91104 | KM 91104. Group: Biochemicals. Alternative Names: 3,4-Dihydroxybenzoic Acid 2-[ (2-Hydroxyphenyl) methylene]hydrazide; 3, 4-Dihydroxy-N- (2-hydroxybenzylidene) benzohydrazide. Grades: Highly Purified. CAS No. 304481-60-5. Pack Sizes: 25mg. Molecular Formula: C14H12N2O4 , Molecular Weight: 272.26. US Biological Life Sciences. | Worldwide |
| KMH-233 | KMH-233, a potent, reversible and selective inhibitor of l-type amino acid transporter LAT1/SLC7A5, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 ?M) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 ?M)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1941174-13-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120139. | |
| KML29 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KML-29 | KML-29, a effective MAGL inhibitor, has been found to have probable effect against neuropathic pain. IC50: 15, 43, and 5.9 nM (mouse, rat, and human brain proteomes). Uses: Kml-29 is a effective magl inhibitor that has been found to have probable effect against neuropathic pain. Synonyms: KML-29; KML29; KML 29; SCHEMBL15100615; SXHQLPHDBLTFPM-UHFFFAOYSA-N; BDBM179929; IN2183; ZINC97949367. Grades: 98%. CAS No. 1380424-42-9. Molecular formula: C24H21F6NO7. Mole weight: 549.42. | |
| KML-29 | KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid. Group: Biochemicals. Alternative Names: 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic Acid 2,2,2-Trifluoro-1-(trifluoromethyl)ethyl Ester; 1,1,1,3,3,3-Hexafluoropropan-2-yl 4- (Bis (benzo[d][1, 3]dioxol-5-yl) (hydroxy) methyl) piperidine-1-carboxylate; KML29. Grades: Highly Purified. CAS No. 1380424-42-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| KMO Inhibitor I, Ro 61-8048 (Kynurenine-3-Monooxygenase Inhibitor I, Ro 61-8048 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-benzenesulfonamide Dimethoxy-nitrophenyl-thiazolyl-benzenesulfonamide, Kynurenine-3-Hydroxylase Inhibitor I, Ro 61-8048) | A cell-permeable thiazolyl Benzene sulfonamide compound that acts as a potent, competitive and reversible inhibitor of kynurenine-3-monooxygenase activity (Ki=4.8nM; IC50=37nM). Reported to increase the circulating levels of kynurenic acid (KYNA), an excitatory amino acid receptors antagonist, lower reactive oxygen species [ROS], reduce neuronal loss and enhance the survival rate in several neuronal disease models. An orally bioavilable KMO Inhibitor II, JM6, a prodrug of Ro 61-8048 is also available. Group: Biochemicals. Grades: Highly Purified. CAS No. 199666-03-0. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 421.5. US Biological Life Sciences. | Worldwide |
| KN62 | KN62 is a P2X7R antagonist (hP2X7 IC50=51 nM) and Ca2+/calmodulin-dependent protein kinase II inhibitor. KN62 inhibits the invasiveness of cancer cells in vitro and in vivo KN62 causes retrograde amnesia in the rat. KN62 attenuates glutamate release by inhibiting voltage-dependent Ca(2+)-channels. The effect of KN62 on Ca(2+)-influx appears to be specific to slowly-or non-inactivating conductances, and therefore presents KN62 as a potentially useful tool. Uses: Designed for use in research and industrial production. Additional or Alternative Names: KN62; KN-62; KN 62. Product Category: Antagonists. Appearance: Solid powder. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.85. Purity: >98%. IUPACName: (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate. Canonical SMILES: CN([C@@H](CC1=CC=C(OS(=O)(C2=C3C(C=NC=C3)=CC=C2)=O)C=C1)C(N4CCN(C5=CC=CC=C5)CC4)=O)S(C6=CC=CC7=C6C=CN=C7)(=O)=O. Product ID: ACM127191973. Alfa Chemistry ISO 9001:2015 Certified. | |
| KN 62 | 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester C38H35N5O6S2Fw 721.88 98% white solid, selectively inhibits rat brain, Ca2+/cadmodulin-dependent protein kinase II, soluble in DMSO, MeOH. selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II. CAS No. 127191-97-3. Product ID: 1-01108. Molecular formula: C38H35N5O6S2. Mole weight: 721.88. Purity: 0.98. Properties: white solid, soluble in DMSO, MeOH, 4°C. Reference: J. Biol. Chem., 267, 12511, 1992; J. Biol. Chem., 265, 4315, 1990. Categories: KN-62. |  |
| KN-62 | KN-62 suppresses the A23187-induced autophosphorylation of Ca2+/CaM kinase in PC12 D cells. Uses: Enzyme inhibitors. Synonyms: KN-62; KN 62; KN62. Grades: >98%. CAS No. 127191-97-3. Molecular formula: C38H35N5O6S2. Mole weight: 721.84. | |
| KN-62 | ?95%, powder. Group: Fluorescence/luminescence spectroscopy. | |
| KN-62 | KN-62. Group: Biochemicals. Grades: Purified. CAS No. 127191-97-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-62 (1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4- (2-[ (5-Isoquinolinylsulfonyl) methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl) phenyl Ester,) | A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II. Group: Biochemicals. Alternative Names: 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4- (2-[ (5-Isoquinolinylsulfonyl) methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl) phenyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| KN-62 - CAS 127191-97-3 | A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Group: Fluorescence/luminescence spectroscopy. | |
| KN 92 | KN 92. Group: Biochemicals. Grades: Purified. CAS No. 1135280-28-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-92 | KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cell. Synonyms: KN 92; KN92. Grades: >98%. CAS No. 176708-42-2. Molecular formula: C24H25ClN2O3S. Mole weight: 456.98. | |
| KN-92 - CAS 1135280-28-2 | KN-92, CAS 1135280-28-2, is useful as a negative control for KN-93 (Cat. No. 422708), a Ca2+/CaM Kinase II inhibitor. Group: Fluorescence/luminescence spectroscopy. | |
| KN-92 hydrochloride | KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII). At concentrations up to 25 μM, KN-92 is ineffective at inhibiting CaMKII or arresting cell growth of NIH 3T3 fibroblasts. It is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. Synonyms: KN 92 hydrochloride; KN92 hydrochloride. Grades: >98%. CAS No. 1431698-47-3. Molecular formula: C24H26Cl2N2O3S. Mole weight: 493.45. | |
| KN-92 phosphate | KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93. Synonyms: KN-92 phosphate; KN 92 phosphate; KN92 phosphate. Grades: >98%. CAS No. 1135280-28-2. Molecular formula: C24H28ClN2O7PS. Mole weight: 554.98. | |
| KN 93 | KN 93. Group: Biochemicals. Grades: Purified. CAS No. 139298-40-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| KN-93 | KN-93. Group: Biochemicals. Alternative Names: N- [2- [ [ [3- (4-Chlorophenyl) -2-propen-1-yl] methylamino] methyl] phenyl] -N- (2-hydroxyethyl) -4-methoxy Benzene sulfonamide. Grades: Highly Purified. CAS No. 139298-40-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C26H29ClN2O4S. US Biological Life Sciences. | Worldwide |
| KN-93 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| KN-93 | KN-93 is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 139298-40-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465. | |
| KN-93 | KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step. Uses: Protein kinase inhibitors. Synonyms: KN 93; KN93. Grades: >98%. CAS No. 139298-40-1. Molecular formula: C26H29ClN2O4S. Mole weight: 501.04. | |
| KN-93 - CAS 139298-40-1 | A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM). Group: Fluorescence/luminescence spectroscopy. | |
| KN-93 hydrochloride | KN-93 hydrochloride is a cell-permeable, reversible and competitive inhibitor calmodulin-dependent kinase type II ( CaMKII ) with a K i of 370 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1956426-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15465A. | |
| KN-93 hydrochloride | KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII), a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. KN-93 is commonly used for determining cellular functions. Synonyms: KN-93 HCl; N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide hydrochloride. Grades: ≥98%. CAS No. 1956426-56-4. Molecular formula: C26H29ClN2O4S·HCl. Mole weight: 537.5. | |
| KN 93 phosphate | KN 93 phosphate. Group: Biochemicals. Grades: Purified. CAS No. 1188890-41-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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