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| Product | Description | |
|---|---|---|
| Kigamicin A | Kigamicin A is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. Molecular formula: C34H35NO13. Mole weight: 665.64. |  |
| Kigamicin B | Kigamicin B is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. Molecular formula: C40H45NO15. Mole weight: 779.78. | |
| Kigamicin C | Selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions; active in vivo against a human pancreatic cancer xenograft model; also inhibits the growth of gram positive bacteria including MRSA, but is not active against gram negative bacteria. Synonyms: (1S,3R,4S,8aR,11aR)-3-[[(2S,5S,6R)-5-[(2,6-dideoxy-3-O-methyl-b-D-arabinohexopyranosyl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-1,2,3,4,8a,9,11,11a,13,14-decahydro-1,4,17,18-tetrahydroxy-11a-methyl-oxazolo[3,2-b]xantheno[4',3',2':4,5][1,3]benzodioxino[7,6-g]isoquinoline-16,19-dione. Grade: >98% by HPLC. CAS No. 680571-51-1. Molecular formula: C41H47NO16. Mole weight: 809.81. | |
| Kigamicin C | Kigamicin C was discovered by an anti-austerity strategy targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blocking of the activation of PKB/Akt caused by the withdrawal of nutrients. Active in vivo against a human pancreatic cancer xenograft model. Also inhibits the growth of Gram-positive bacteria including Staphylococcus aureus MRSA, but not active against Gram-negative bacteria. Group: Biochemicals. Grades: Highly Purified. CAS No. 680571-51-1. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Kigamicin D | Kigamicin D is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. It also shows effect against L-1210 LB32T and other genera tumor cells with IC50 of 1 μg/mL. Synonyms: 1,2,3a,4,6,7,10,11,12,13-Decahydro-11-[[5-[[5-[(tetrahydro-5-hydroxy-4-methoxy-6-methyl-2H-pyran-2-yl)oxy]tetrahydro-4-methoxy-6-methyl-2H-pyran-2-yl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-10,13,15,16-tetrahydroxy-3a-methyl-7,8-(methylenedioxy)-17a-aza-3,9-dioxa-17aH-cyclopenta[b]hexaphene-14,17-dione. Molecular formula: C48H59NO19. Mole weight: 953.98. | |
| Kijanimicin | A tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin; contains an unusual nitroaminoglycoside; a potent antibacterial, antimalarial and antitumour active; inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). Synonyms: NSC 329515; Sch 25663. Grade: >99% by HPLC. CAS No. 78798-08-0. Molecular formula: C67H100N2O24. Mole weight: 1317.51. | |
| Kijanimicin (Antibiotic Sch 25663) | Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitro-aminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor activity. However, several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signaling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. While tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signaling pathway. Group: Biochemicals. Alternative Names: Antibiotic Sch 25663. Grades: Highly Purified. CAS No. 78798-08-0. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Kimcuongin | Kimcuongin is a coumarin isolated from Murraya paniculata leaves that has the potential to be used as a vasodilator. Synonyms: [1-(7-methoxy-2-oxochromen-8-yl)-3-methyl-1-oxobut-2-en-2-yl] 3-methylbut-2-enoate. Grade: 98.5%. CAS No. 1872403-23-0. Molecular formula: C20H20O6. Mole weight: 356.374. | |
| KIN1148 | KIN1148, a small-molecule IRF3 agonist, is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. Uses: Scientific research. Category: Signaling pathways. CAS No. 1428729-56-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101950. |  |
| KIN-8194 | KIN-8194 is an orally active dual inhibitor of HCK and BTK, with IC50 values of 0.915 and <0.495 nM, respectively. KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma (MCL). KIN-8194 overcomes ibrutinib (HY-10997) resistance with a survival benefit in TMD-8 ABC DLBCL xenografted mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 330786-01-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15805. | |
| Kinamycin A | Kinamycin A is produced by the strain of Str. murayamaensis. Kinamycin A has antibacterial and mycobacterial effects, but it has weak activity against gram-negative bacteria. Synonyms: BRN 0505520; 2,3,4-Tri(acetyloxy)-1,2,3,4,6,11-hexahydro-1,7-dihydroxy-3-methyl-6,11-dioxo-5H-benzo(b)carbazole-5-nitrile; 1,2,3-Tris(acetyloxy)-11-diazonio-4,9-dihydroxy-2-methyl-10-oxo-2,3,4,10-tetrahydro-1H-benzo[b]fluoren-5-olate. Grade: >98%. CAS No. 35303-12-9. Molecular formula: C24H20N2O10. Mole weight: 496.42. | |
| Kinamycin B | Kinamycin B is produced by the strain of Str. murayamaensis. Kinamycin B has antibacterial and mycobacterial effects, but it has weak activity against gram-negative bacteria. Synonyms: BRN 0503790; (1R,2R,3R,4S)-2-acetyloxy-11-diazonio-1,3,4,10-tetrahydroxy-2-methyl-9-oxo-3,4-dihydro-1H-benzo[b]fluoren-5-olate. Grade: >98%. CAS No. 35303-13-0. Molecular formula: C20H16N2O8. Mole weight: 412.35. | |
| Kinase Inhibitor Library | A unique collection of 2230 kinase inhibitors for high throughput screening and high content screening for drug discovery in kinase related diseases; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Targets include MAPK, PI3K, JAK, STAT, CDK, MEK, Insulin/IGF receptors, CaM Kinease II, PKA, JNK, PKC, RAF, EGFR, SAPK, GSK, MLCK, Src-family, IKK, PDGFR, VEGFR, etc; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1600. Categories: Kinase Inhibitor Libraries. |  |
| Kinase, Natto fermentation | Kinase, Natto fermentation is a potent fibrinolytic enzyme. Kinase, Natto fermentation can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Kinase, Natto fermentation can be used for the research of cardiovascular diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 133876-92-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-P2373. | |
| Kinesin family member 27, isoform CRAb (84-103) | A peptide fragment of Kinesin family member 27, isoform CRAb. KIF27 plays an essential role in motile ciliogenesis. Synonyms: Kinesin-Like Protein KIF27 isoform CRA_b (84-103). | |
| Kinesin-like protein KIF20A (12-20) | Kinesin-like protein KIF20A (12-20) is a 9-aa peptide. Kinesin-like protein KIF20A is a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Synonyms: Mitotic kinesin-like protein 2 (12-20); Rab6-interacting kinesin-like protein (12-20). | |
| Kinesin-like protein KIF20A (284-293) | Kinesin-like protein KIF20A (284-293) is a 10-aa peptide. Kinesin-like protein KIF20A is a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Synonyms: Mitotic kinesin-like protein 2 (284-293); Rab6-interacting kinesin-like protein (284-293). | |
| Kinesin-like protein KIF20A (809-817) | Kinesin-like protein KIF20A (809-817) is a 9-aa peptide. Kinesin-like protein KIF20A is a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Synonyms: Mitotic kinesin-like protein 2 (809-817); Rab6-interacting kinesin-like protein (809-817). | |
| Kinetensin | Kinetensin (human) is an endogenous neurotensin-like peptide originally isolated from pepsin-treated human plasma. It increases vascular permeability and releases histamine from rat mast cells. It induces histamine release from rat peritoneal mast cells with ED50 value of 10 mM in vitro. Synonyms: Kinetensin (human); Neurotensin-related peptide; H-Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu-OH; L-isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-leucine. Grade: ≥95%. CAS No. 103131-69-7. Molecular formula: C56H85N17O11. Mole weight: 1172.38. | |
| Kinetin | A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures. Group: Biochemicals. Alternative Names: N-(2-Furanylmethyl)-. Grades: Highly Purified. CAS No. 525-79-1. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| Kinetin | Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Furfuryladenine; N6-Furfuryladenine. CAS No. 525-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g. Product ID: HY-N0160. | |
| Kinetin Hydrochloride | Kinetin Hydrochloride. Alternative Names: KINETIN HYDROCHLORIDE;6-FURFURYLAMINOPURINE HYDROCHLORIDE;TIMTEC-BB SBB003138;KINETIN HYDROCHLORIDE 98% (HPLC);KINETIN HYDROCHLORIDE 98%;Kinetinehydrochloride;N6-Furfuryladenine,HCl;6-Furfurylaminopurine, N6-Furfuryladenine. CAS No. 177966-68-6. Purity: 96%. Product ID: ACM177966686. Molecular formula: C10H10ClN5O. Mole weight: 251.67. IUPAC Name: N-(furan-2-ylmethyl)-7H-purin-6-amine. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Kinetin Riboside (6-Furfurylaminopurine Riboside, N6-Furfuryladenosine) | Used as an anticancer and antiviral agent. Group: Biochemicals. Alternative Names: 6-Furfurylaminopurine Riboside, N6-Furfuryladenosine. Grades: Highly Purified. Pack Sizes: 500mg. US Biological Life Sciences. | Worldwide |
| Kin of IRRE-like protein 3 isoform 2 precursor (402-419) | A peptide fragment of Kin of IRRE-like protein 3 isoform 2 precursor. Kin of IRRE-like protein 3 probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Synonyms: Kin of irregular chiasm-like protein 3 isoform 2 precursor (402-419). | |
| Kinsenoside | Kinsenoside. Group: Biochemicals. Alternative Names: (+)-Kinsenoside. Grades: Plant Grade. CAS No. 151870-74-5. Pack Sizes: 25mg. Molecular Formula: C10H16O8, Molecular Weight: 264.228999999999. US Biological Life Sciences. | Worldwide |
| Kinsenoside | Kinsenoside is the main active ingredient of the genus plant, and has various biological activities. Kinsenoside and Nrf2 depend on the protection of nuclear cells (NPCs), which significantly reduces their ability to survive. Kinsenoside Active NPC Medium AKT-ERK1/2-Nrf2 Signal passage, Prevent physical decline, aging, harmonious physical function impairment. Kinsenoside can improve the puncture guide model for intermediate vertebral wall discharge (IDD). Uses: Scientific research. Category: Signaling pathways. CAS No. 151870-74-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2292. | |
| KIRA6 | KIRA6 is an advanced small-molecule IRE1α RNase kinase inhibitor with an IC50 of 0.6 μM[2]. KIRA6 can trigger an apoptotic response[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1589527-65-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19708. | |
| Kira8 | Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG-18. CAS No. 1630086-20-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114368. | |
| Kirenol | Kirenol. Group: Biochemicals. Grades: Plant Grade. CAS No. 52659-56-0. Pack Sizes: 20mg. Molecular Formula: C20H34O4, Molecular Weight: 338.48. US Biological Life Sciences. | Worldwide |
| Kirenol | Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a Kd value of 5.47 μM against the target CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53 and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the CK2/AKT and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 52659-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0559. | |
| Kirromycin | Kirromycin is an antibiotic originally isolated from Streptomyces. It was shown to inhibit protein biosynthesis via acting on elongation factor Tu (EF-Tu). Synonyms: Mocimycin; Delvomycin. Grade: ≥95%. CAS No. 50935-71-2. Molecular formula: C43H60N2O12. Mole weight: 796.94. | |
| Kirrothricin | Kirrothricin is originally isolated from Str. cinnamomeus Tu89. It has antibacterial action, but no activity to subtilis, Escherichia coli and fungi. Synonyms: 2H-Pyran-2-acetamide, N-((2E,4E,6S,7S,9S,10E,12E,14E,16E)-8,9-dihydroxy-6-methoxy-5,7,17-trimethyl-18-oxo-18-(1,2,5,6-tetrahydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-2,4-dihydroxy-5,5-dimethyl-6-((1E,3Z)-1,3-pentadienyl)-, (alphaS,2S,4S,6S)-. CAS No. 79190-00-4. Molecular formula: C44H64N2O10. Mole weight: 780.98. | |
| Kisspeptin-10 | Kisspeptin-10 is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Synonyms: Metastin (45-54); Kisspeptin-10 (human); KP-10; H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2; L-tyrosyl-L-asparagyl-L-tryptophyl-L-asparagyl-L-seryl-L-phenylalanyl-glycyl-L-leucyl-L-arginyl-L-phenylalaninamide. CAS No. 374675-21-5. Molecular formula: C63H83N17O14. Mole weight: 1302.4. | |
| Kisspeptin-10, human | Kisspeptin-10, human is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, human acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 374675-21-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0254. | |
| Kisspeptin-10, rat | Kisspeptin-10, rat is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Synonyms: Kisspeptin-10 rat; Kisspeptin-10 (rat); Kisspeptin-10 (mouse, rat); H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2. CAS No. 478507-53-8. Molecular formula: C63H83N17O15. Mole weight: 1318.4. | |
| Kisspeptin-14 human | Kisspeptin-14 human is a peptide hormone encoded by the KiSS-1 gene. Kisspeptin-14 human, along with several other similar peptide hormones, is produced from a common precursor protein by cleavage by different proteases. Kisspeptin-14 human is an endogenous ligand of KISS1R. Kisspeptin-14 human has the same receptor binding efficiency and potency as full-length kisspeptin. Kisspeptin-14 human binds to its receptor GPR54 and is able to activate this G protein-coupled receptor and activate multiple intracellular signaling pathways. Kisspeptin-14 human can be used to study reproductive development and tumor metastasis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 374675-19-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10489. | |
| Kisspeptin-54(human) | Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Metastin(human). CAS No. 374683-24-6. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-P1022. | |
| Kistamicin A | Kistamicin A is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 3.6 and 44. It also has anti-gram-positive bacterial effects. Synonyms: Kistamycin A. CAS No. 155683-50-4. Molecular formula: C61H51ClN8O15. Mole weight: 1171.55. | |
| Kistamicin B | Kistamicin B is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 1.8 and 30. Synonyms: Kistamycin B. CAS No. 155683-51-5. Molecular formula: C70H60ClN9O16. Mole weight: 1318.73. | |
| KIT-6 | KIT-6. CAS No. 12173-28-3. |  |
| Kita-kyushu lung cancer antigen 1 (76-84) | Kita-kyushu lung cancer antigen 1 (76-84) is a bioactive peptide of Kita-kyushu lung cancer antigen 1. The tumor-associated antigen Kita-Kyushu lung cancer antigen-1 has been reported as not being expressed in normal tissues, except for the testis, and in the setting of non-small cell lung cancer. Synonyms: KK-LC-1 (76-84); Cancer/Testis Antigen 83 (76-84). | |
| Kitamycin A | It is originally isolated from Strptomyces sp. K385. Kitamycin A can inhibit the activity of plant growth. Molecular formula: C23H32N2O8. Mole weight: 464.51. | |
| Kit for Creating Hydrophilic PDMS Surface | Kit for Creating Hydrophilic PDMS Surface. | |
| KI-TOX-A3 | KI-TOX-A3 is a TOX protein-protein interaction inhibitor that blocks the TOX-KAT7 protein-protein interaction with an IC50 of 0.51 μM. KI-TOX-A3 induces proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses exhaustion of CD8+ T cells, and inhibits the proliferation of T cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 shows promise for use in studies of hematological malignancies such as T-ALL[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1351116-34-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176244. | |
| Kiwifruit concentrate powder | Kiwifruit concentrate powder contains a naturally potent proteolytic enzyme, actinidin, which enhances protein digestion. In-vitro studies have shown that actinidin enhances the digestion of a number of different food proteins, including soy, red meat, milk, gluten and gliaden. Kiwifruit concentrate powder may also help to improve gut motility, which is an important contributor to improved bowel function. The active enzyme content of Kiwifruit concentrate powder is protected by specialised pre-processing and freeze drying techniques which maintain optimal temperature and pH conditions. Group: Others. Activity: >20,000 u/g. Appearance: green to brown powder. Form: Freeze dried powder. Source: green kiwifruit. Actinidin; Kiwifruit concentrate powder; Kiwifruit powder. Cat No: KCP-001. |  |
| Kiwi Powder | Kiwi fruit powder is made from fresh kiwi (Actinidia Chinensis), adopt the advanced spray drying technology. Kiwi juice powder is a rich source of vitamin C and vitamin A. Kiwi fruit powder can be used for drinks, health care products, baby food, puffed food, baking food, ice cream, and oatmeal. Group: Others. Kiwi Powder; Actinidia chinensis. Cat No: EXTC-083. | |
| KJ Pyr 9 | KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay. Uses: Scientific research. Category: Signaling pathways. CAS No. 581073-80-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19735. | |
| KKL-40 | KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 865285-47-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116863. | |
| KL001 | KL001. Group: Biochemicals. Alternative Names: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide. Grades: Highly Purified. CAS No. 309928-48-1. Pack Sizes: 5mg, 10mg, 50mg. Molecular Formula: C21H22N2O4S, Molecular Weight: 398.48. US Biological Life Sciences. | Worldwide |
| KL001 | KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 309928-48-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108468. | |
| KL 001 | KL 001. Group: Biochemicals. Grades: Purified. CAS No. 309928-48-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KL044 | KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1801856-93-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119506. | |
| KL-11743 | KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC50s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1369452-53-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145597. | |
| KL1333 | KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1800405-30-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128895. | |
| KL201 | KL201 a circadian clock modulator, is a isoform-selective cryptochrome 1 (CRY1) stabilizer. KL201 has no stabilizing effect on CRY2. KL201 lengthens the period of circadian rhythms in cells and tissues[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 302939-48-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134194. | |
| KL-50 | KL-50 is a selective toxin toward tumors that lack the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O6-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1161826-19-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164496. | |
| KLD12 | KLD12, a hydrogel obtained from the self-assembled peptide, regulates in vitro chondrogenesis of bovine bone marrow stromal cells. Synonyms: Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2; N-acetyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucinamide; L-Leucinamide, N2-acetyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-. Grade: ≥95% by HPLC. CAS No. 800379-47-9. Molecular formula: C68H122N16O19. Mole weight: 1467.79. | |
| KLD-12 | KLD-12. CAS No. 800379-47-9. Molecular formula: C68H122N16O19. Mole weight: 1467.79. Purity: 99%. | |
| KLD-12 TFA | KLD-12 TFA. Molecular formula: C68H122N16O19.Xc2hf3o2. Mole weight: 1467.79. Purity: 95%. | |
| Klemm's No.2 Reagent | Stain or tint etch for etching cast iron, copper and tin. | |
| Klemm's Reagent | For etching alpha-beta brass, bonze, tin, cast iron phosphides, ferrite, martensite, retained austenite, zinc and steel temper embrittlement. | |
| KLF10-IN-1 | KLF10-IN-1 (#48-15) is a KLF10 inhibitor with an IC50 value of 40 μM for KLF10 reporter gene. KLF10-IN-1 can inhibit KLF10-DNA binding and transcriptional activity, block the conversion of CD4+CD25 T cells to CD4+CD25+T regulatory cells, and inhibit the expression of KLF10 target genes. KLF10-IN-1 can be used as a useful mechanistic probe to study KLF10-mediated effects and T regulatory cell biology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197834-98-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W181026. | |
| KLH45 | KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1632236-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103060. | |
| KLTWQELYQLKYKGI | KLTWQELYQLKYKGI is a VEGF mimetic peptide designed based on the VEGF helix sequence 17-25, with the ability to activate VEGF receptors and exert pro-angiogenic biological activity. KLTWQELYQLKYKGI effectively promotes the attachment, spreading and proliferation of human umbilical vein endothelial cells. KLTWQELYQLKYKGI enhances the proliferation, migration and osteogenic differentiation of bone marrow stromal cells (BMSCs). KLTWQELYQLKYKGI synergistically accelerates angiogenesis and bone regeneration in rat cranial defect models. KLTWQELYQLKYKGI can be used for the research of brain tissue engineering and traumatic brain injury repair and biomaterials for bone tissue engineering and bone repair[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 917760-16-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5558. | |
| KM04416 | KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26530-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148685. | |
| KM 11060 | KM 11060. Group: Biochemicals. Grades: Purified. CAS No. 774549-97-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| KM91104 | KM91104 is a cell-permeable V-ATPase a3-b2 inhibitor (IC50 = 2.3 μM). KM91104 reduces the metabolic activity, cell proliferation capacity and V-ATPase subunit protein expression levels of primary human hepatic stellate cells, increases intracellular ATP levels and decreases cytoplasmic pH. KM91104 reduces TLR4 expression on the surface of oligodendrocyte precursor cells, blocks the ENV-TLR4 interaction, and reverses oligodendrocyte myelination defects induced by ENV protein[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 304481-60-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135474. | |
| KME-2780 | KME-2780 is the orally active inhibitor for IRAK1 and IRAK4 with IC50s of 19 nM and 0.5 nM. KME-2780 can be used for research of dysregulation of innate immune signaling and hematologic malignancies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2968466-26-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160487. | |
| KMG-104 | KMG-104 is a cell-impermeant highly selective fluorescent Mg2+ probe. KMG-104 has been used widely and revealed Mg2+ mobilization in cytoplasm in various types of cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 852057-94-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-139646. | |
| KMG-1068 | KMG-1068 (Compound 4a), a molecular glue, is a GSPT1/2 degrader. KMG-1068 effectively induces the CRBN-dependent degradation of GSPT1/2 by binding to the IMiD binding site on CRBN, facilitating the formation of a ternary complex with GSPT1/2. KMG-1068 is promising for research of cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3113750-79-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-172770. | |
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