A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Ketotifen N-oxide. Group: Biochemicals. Alternative Names: 4, 9-Dihydro-4-(1-methyl-1-oxido-4-piperidinylidene)-10H-benzo[4, 5]cyclohepta[1, 2-b]thiophen-10-one; 4, 9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo[4, 5]cyclohepta[1, 2-b]thiophen-10-one N-oxide. Grades: Highly Purified. CAS No. 88456-70-6. Pack Sizes: 100mg, 250mg. Molecular Formula: C19H19NO2S. US Biological Life Sciences.
Worldwide
Kevetrin
Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. Synonyms: 4-Isothioureidobutyronitrile; NSC-525990; Carbamimidothioic acid, 3-cyanopropyl ester; thioureido butyronitrile. CAS No. 500863-50-3. Molecular formula: C5H9N3S. Mole weight: 143.21.
Kevetrin hydrochloride
Kevetrin hydrochloride is a water-soluble small molecule with potential antineoplastic activity. Uses: Inhibiting cancer cell growth and causing tumor cell apoptosis. Synonyms: UNII-NL6L2371DP; thioureidobutyronitrile; 3-cyanopropyl carbamimidothioate;hydrochloride; Carbamimidothioic acid, 3-cyanopropyl ester, monohydrochloride. Grades: ≥95%. CAS No. 66592-89-0. Molecular formula: C5H10ClN3S. Mole weight: 179.66.
Kex2 Protease from Saccharomyces cerevisiae, Recombinant
Kex2 is a Ca2+-dependent serine protease and cleaves at C-terminal site of Lys-Arg, Arg-Arg, Pro-Arg in pro-α-factor and killer-toxin precursors maturing, it was discovered in Saccharomyces cerevisiae. But Kex2 cant recognize and cut a single basic amino acid,such as carboxyl end peptide bond of arginine and lysine. Recombinant Kex2 is a genetically engineered protein expressed in Pichia pastoris and purified by high pressure liquid chromatography. The activity of Kex2 is not affected by the conventional serine protease inhibitors such as PMSF, TPCK, TLCK inhibition. Group: Enzymes. Synonyms: KEX2 protease; KEX2; protease; kexin; EC 3.4.21.61. Enzyme Commission Number: EC 3.4.21.61. Mole weight: 67±6.7 kD. Activity: >10 unit/mg protein. Storage: Recommended storage temperature: 2°C-8°C.Transport condition: blue ice to keep the environment cool.It should be stored in 20mM NaAc-HAc (pH 5.0-5.5) and 2mM Ca2+. It is stable after 5 cycles freezing and thawing. Form: White lyophilized. Source: Pichia pastoris. Species: Saccharomyces cerevisiae. KEX2 protease; KEX2; protease; kexin; EC 3.4.21.61. Cat No: NATE-1891.
kexin
A Ca2+-activated peptidase of peptidase family S8, containing Cys near the active site His, and inhibited by p-mercuribenzoate. Similar enzymes occur in mammals. Group: Enzymes. Synonyms: yeast KEX2 protease; proteinase yscF; prohormone-processing endoprotease; paired-basic endopeptidase; yeast cysteine proteinase F (misleading); paired-basic endopeptidase; andrenorphin-Gly-generating enzyme; endoproteinase Kex2p; gene KEX2 dibasic proteinase; Kex 2p proteinase; Kex2 endopeptidase; Kex2 endoprotease; Kex2 endoproteinase; Kex2 protease; proteinase Kex2p; Kex. Enzyme Commission Number: EC 3.4.21.61. CAS No. 99676-46-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4152; kexin; EC 3.4.21.61; 99676-46-7; yeast KEX2 protease; proteinase yscF; prohormone-processing endoprotease; paired-basic endopeptidase; yeast cysteine proteinase F (misleading); paired-basic endopeptidase; andrenorphin-Gly-generating enzyme; endoproteinase Kex2p; gene KEX2 dibasic proteinase; Kex 2p proteinase; Kex2 endopeptidase; Kex2 endoprotease; Kex2 endoproteinase; Kex2 protease; proteinase Kex2p; Kex2-like precursor protein processing endoprotease; prohormone-processing KEX2 proteinase; prohormone-processing proteinase; proprotein convertase; protease KEX2; Kex2 proteinase; Kex2-like endoproteinase. Cat No: EXWM-4152.
KF 13218
KF 13218, a novel pyridobenzazepinone derivative, inhibited human and bovine platelet thromboxane synthase with IC50 values of 27 +/- 5.8 nmol/l (mean +/- S.E.M.) and 36 +/- 6.9 nmol/l, respectively. Synonyms: (6Z)-6-(6-methyl-5-oxopyrido[4,3-c][1]benzazepin-11-ylidene)hexanoic acid; 11-(5-carboxypentylidene)-6-methyl-5,11-dihydropyrido(4,3-c)(1)benzazepin-5(6H)-one; KF 13218; KF-13218; KF13218. CAS No. 127654-03-9. Molecular formula: C20H20N2O3. Mole weight: 336.38.
KF21213
KF21213 is a highly selective ligand for mapping CNS adenosine A2A receptors. The Ki values of KF21213 were 3.0 nM for the adenosine A2A receptors and >10,000 nM for the adenosine A1 receptors. KF21213 showed a slightly higher affinity for the A2A receptors and a much lower affinity for the A1 receptors than KF18446 (Ki= 5.9 nM for A2A receptors and Ki= 1600 nM for the A1 receptors). Synonyms: 8-[2-(4-methoxy-2,3-dimethylphenyl)ethenyl]-1,3,7-trimethylpurine-2,6-dione; 8-(2,3-dimethyl-4-methoxystyryl)-1,3,7-trimethylxanthine; KF 21213; KF-21213; KF21213. CAS No. 155271-17-3. Molecular formula: C19H22N4O3. Mole weight: 354.4.
KF-25706
KF25706 is derivative of radicicol that binds to the Hsp90 chaperone machinery with IC50 of 39 nM. Synonyms: KF-25706; KF 25706; KF25706; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-oxime, (1aS,?2Z,?4E,?14R,?15aS)?-,UCS1006-S15. Grades: >98%. CAS No. 184537-25-5. Molecular formula: C18H18ClNO6. Mole weight: 379.79.
KF 38789
KF 38789 is a selective inhibitor of P-selectin-mediated cell adhesion with IC50 value of 1.97 μM. It shows no effects on E-selectin-mediated and L-selectin- adhesion. It blocks leukocyte accumulation in vivo and P-selectin-mediated binding in vitro. It also inhibits the binding of U937 cells to immobilized P-selectin IgG chimeric protein with an IC50 value of 1.97 μM. Synonyms: KF 38789; KF38789; KF-38789; 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one. Grades: ≥97% by HPLC. CAS No. 257292-29-8. Molecular formula: C19H21NO5S. Mole weight: 375.44.
KF 38789
KF 38789. Group: Biochemicals. Grades: Purified. CAS No. 257292-29-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
KF-55823
KF55823 is a derivative of radicicol that binds to the Hsp90 chaperone machinery. Synonyms: KF-55823; KF 55823; KF55823. Grades: >98%. CAS No. 452083-20-4. Molecular formula: C24H27ClN2O7. Mole weight: 490.94.
KF-58333
KF58333 is a novel derivative of radicicol that binds to the Hsp90 chaperone machinery, depletes p210Bcr-Abl and Raf-1 proteins followed by induction of erythroid differentiation and G1 phase accumulation, and induces apoptosis in human CML cells. Synonyms: KF-58333; KF 58333; KF58333; 6H-Oxireno [e]? [2]?benzoxacyclotetradec?in-6, ?12 (7H) ?-dione, 8-chloro-1a,?14,?15,?15a-tetrahydro-9,?11-dihydroxy-14-methyl-, 6-[O-[2-(2-oxo-1-pyrrolidinyl)?ethyl]?oxime]?, (1aR,?2Z,?4E,?6E,?14R,?15aR)?- (9CI). Grades: >98%. CAS No. 308244-21-5. Molecular formula: C24H27ClN2O7. Mole weight: 490.93.
K-FGF
It is a cell penetrating peptide. Synonyms: H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-OH; Human FGF-4; hFGF-4; Heparin-binding growth factor 4; K-fibroblast growth factor; HBGF-4; transforming protein KS3; L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-proline. Grades: >98%. Molecular formula: C74H130N16O17. Mole weight: 1515.95.
KFM19
KFM19 is a selective adenosine A1-antagonist with good bioavailability (IC50= 50 nM). Synonyms: 8-(3-oxocyclopentyl)-1,3-dipropyl-7H-purine-2,6-dione; ((S)-(-)-8-(3-oxocyclopentyl)-1,3-dipropyl-7H-purine-2,6-dione) 1H-Purine-2,6-dione, 3,7-dihydro-8-(3-oxocyclopentyl)-1,3-dipropyl-; BIIP 20; BIIP-20; KFM 19; KFM-19; BIIP20; KFM19. CAS No. 133058-72-7. Molecular formula: C16H22N4O3. Mole weight: 318.37.
Electroporation buffer optimized for KG1 leukemia cells. Optimized electroporation protocol provided for transfection of si/miRNA, DNA, mRNA, and small proteins. Feature high transfection efficacy and cell viability. Uses: Electroporation of DNA, RNA, protein and small molecules. Product ID: 6576.
Nevada, Texas, USA
KG5
KG5 is an orally active dual PDGFRβ and B-Raf allosteric inhibitor. KG5 also inhibits Flt3 , KIT and c-Raf. KG5 has anticancer, antiangiogenic activities [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 877874-85-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15198.
KG 5
KG 5 is a B-Raf allosteric and PDGFRβ inhibitor. It inhibits FLT3, KIT and c-Raf. It arrests cells in prometaphase and inhibits growth of renal and pancreatic tumors in mice. It also inhibits angiogenesis in a mouse angiogenesis model and disrupts blood vessel formation in zebrafish embryos. It is orally available. Synonyms: KG-5; KG 5; KG5; 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine; 2-Methylsulfanyl-6-[4-[3-[3-(trifluoromethyl)anilino]-1H-1,2,4-triazol-5-yl]phenoxy]pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 877874-85-6. Molecular formula: C20H16F3N7OS. Mole weight: 459.45.
KG-5
KG-5 is an orally available PDGFRß and B-Raf allosteric inhibitor. Group: Inhibitors. Alternative Names: KG-5; KG 5; KG5. CAS No. 877874-85-6. Molecular formula: C20H16F3N7OS. Mole weight: 459.45. Appearance: Solid powder. Purity: >98%. IUPACName: 2- (Methylthio)-6-[4-[5-[[3- (trifluoromethyl)phenyl]amino]-1H-1, 2, 4-triazol-3-yl]phenoxy]-4-pyrimidinamine. Canonical SMILES: NC1=NC (SC)=NC (OC2=CC=C (C3=NNC (NC4=CC=CC (C (F) (F)F)=C4)=N3)C=C2)=C1. Catalog: ACM877874856.
KGA2727
KGA2727 is a selective and potent SGLT1 inhibitor for the treatment of diabete. Its inhibition constant (Ki) values of 97 and 13,600 nM for human (h) SGLT1 and hSGLT2 respectively. It inhibited the absorption of glucose but not that of fructose. Uses: Kga2727 is used for the treatment of diabete. Synonyms: KGA-2727; KGA 2727; 3- (3-{4-[3- (beta-D-glucopyranosyloxy) -5-isopropyl-1Hpyrazol-4-ylmethyl]-3-methylphenoxy}propylamino) propionamide. Grades: 98%. CAS No. 666842-36-0. Molecular formula: C26H40N4O8. Mole weight: 536.63.
KH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC 50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1215115-03-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134601.
KH7
KH7 is a soluble adenylyl cyclase (sAC) -specific inhibitor, with IC 50 s of 3-10 μM toward both recombinant purified human sAC t protein and heterologously expressed sACt in cellular assays [1]. KH7 is also a cAMP inhibitor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 330676-02-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103194.
KH 7
KH 7 is a novel and selective inhibitor of soluble adenylyl cyclase (Sac) with IC50 value of 3 - 10 μM in vivo, which is an essential component of cAMP-signaling and is ubiquitously expressed. It blocks cAMP synthesis and shows an antiapoptotic effect at concentrations of 1 - 100 μM. Synonyms: KH7; KH 7; KH-7; (E)-2-(1H-Benzo[d]imidazol-2-ylthio)-N'-(5-bromo-2-hydroxybenzylidene)propanehydrazide; 2-(1H-Benzoimidazol-2-ylsulfanyl)-propionic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide; (±)-2-(1H-benzimidazol-2-ylthio)propanoic acid 2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide. Grades: ≥99% by HPLC. CAS No. 330676-02-3. Molecular formula: C17H15BrN4O2S. Mole weight: 419.30.
KH 7
KH 7. Group: Biochemicals. Grades: Purified. CAS No. 330676-02-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Khasianine
Khasianine. Group: Biochemicals. Alternative Names: β2-Solamargine. Grades: Plant Grade. CAS No. 32449-98-2. Pack Sizes: 10mg. Molecular Formula: C39H63NO11, Molecular Weight: 721.918. US Biological Life Sciences.
KH-CB19, a CLK1/CLK4 inhibitor, has been found to probably restrain the phosphorylation of serine- and arginine-rich (SR) proteins. IC50: 20 nM for CLK1. Uses: Kh-cb19 is a clk1/clk4 inhibitor that has been found to probably restrain the phosphorylation of serine- and arginine-rich (sr) proteins. Synonyms: KH-CB19; KH CB19; KHCB19. Ethyl 3-[(E)-2-Amino-1-Cyanoethenyl]-6,7-Dichloro-1-Methyl-1h-Indole-2-Carboxylate; 2wu7; GTPL8055; 3761AH. Grades: 98%. CAS No. 1354037-26-5. Molecular formula: C15H13Cl2N3O2. Mole weight: 338.19.
Khellin
5g Pack Size. Group: Bioactive Small Molecules, Biochemicals, Research Organics & Inorganics. Formula: C14H12O5. CAS No. 82-02-0. Prepack ID 13358619-5g. Molecular Weight 260.24. See USA prepack pricing.
Khellin
Khellin is a furochromone that can be isolated from Ammi visnuga L. Khellin is an EGFR inhibitor with an IC 50 of 0.15 μM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 82-02-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1394.
Khellin
Khellin. Group: Biochemicals. Alternative Names: 4,9-Dimethoxy-7-Methyl-5H-Furo[3,2-G]-[1]Benzopyran-5-One. Grades: Highly Purified. CAS No. 82-02-0. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C14H12O5. US Biological Life Sciences.
Worldwide
KHK-IN-1
KHK-IN-1, a pyrimidinopyrimidine derivative, is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in the ATP-binding region at some extent. Uses: Khk-in-1 is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on asp-27b in the atp-binding region at some extent. Synonyms: KHK-IN-8; KHK IN 8; KHKIN8; KHK inhibitor 8; KHK-inhibitor-8; Ketohexokinase Inhibitor 8; ketohexokinase inhibitor. Grades: 98%. CAS No. 1303469-70-6. Molecular formula: C21H26N8S. Mole weight: 422.55.
KHK-IN-1 hydrochloride
The hydrochloride salt form of KHK-IN-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on Asp-27B in the ATP-binding region at some extent. Uses: The hydrochloride salt form of khk-in-1 which is a ketohexokinase inhibitor that could have probable effect against diabetes and obesity by acting on asp-27b in the atp-binding region at some extent. Synonyms: MDK-0485; MDK0485; MDK 0485; ketohexokinase inhibitor. Grades: 98%. CAS No. 1303470-48-5. Molecular formula: C21H27ClN8S. Mole weight: 459.01.
KHR70S hydrogenated rosin resin
KHS101
KHS101 is a selective inducer of neuronal differentiation. Synonyms: N4-Isobutyl-N2-((2-Phenylthiazol-4-Yl)Methyl)Pyrimidine-2,4-Diamine; KHS-101; N4-(2-Methylpropyl)-N2-[(2-Phenyl-1,3-Thiazol-4-Yl)Methyl]Pyrimidine-2,4-Diamine. Grades: 98%. CAS No. 1262770-73-9. Molecular formula: C18H21N5S. Mole weight: 339.5.
KHS 101 hydrochloride
KHS 101 hydrochloride is the hydrochloride salt of KHS 101, which is an inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It induces acceleration of neuronal differentiation in the hippocampal dentate gyrus in vivo and induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3. It suppresses astrocyte formation. It is a useful intermediate. Synonyms: KHS 101 hydrochloride; KHS-101 hydrochloride; KHS101 hydrochloride; N4-(2-Methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-2,4-pyrimidinediamine hydrochloride; N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 1784282-12-7. Molecular formula: C18H22ClN5S. Mole weight: 375.92.
KHS 101 hydrochloride
KHS 101 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.