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| Product | Description | |
|---|---|---|
| ML-290 | ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. Uses: Scientific research. Category: Signaling pathways. CAS No. 1482500-76-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112606. |  |
| ML 297 | ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 can cross the blood-brain barrier with brain-to-plasma ratio of 0.2 in mice model (i.p.). ML 297 is potential for the treatment of epilepsy[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VU 0456810; CID 56642816. CAS No. 1443246-62-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-110192. | |
| ML 297 | ML 297. Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| ML 298 hydrochloride | ML 298 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML311 | ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EU-5346. CAS No. 315698-17-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101778. | |
| ML314 | ML314 is a potent, BBB-penetrant and β-arrestin biased molecule agonist of NTR1 (EC50 = 1.9 μM). ML314 shows good selectivity against NTR2 and GPR35, but does not stimulate Ca2+ mobilization. ML314 can attenuate amphetamine-like hyperlocomotion in dopamine transporter knockout mice. ML314 attenuates methamphetamine-associated hyperlocomotion and potentiates the psychostimulant inhibitory effects of a ghrelin antagonist in wild type mouse model. ML314 also acts as an allosteric enhancer of endogenous neurotensin. ML314 antagonizes G protein signaling. ML314 can be studied in research for methamphetamine abuse conditions[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448895-09-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16639. | |
| ML318 | ML318 is a novel inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1610516-67-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H8F4N2, Molecular Weight: 280.22. US Biological Life Sciences. | Worldwide |
| ML-323 | ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1572414-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17543. | |
| ML324 | ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1222800-79-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12725. | |
| ML329 | ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 19992-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101464. | |
| ML334 | ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LH601A. CAS No. 1432500-66-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110258. | |
| ML335 | ML335 is a selective activator of both TREK-1 and TREK-2. Uses: Scientific research. Category: Signaling pathways. CAS No. 825658-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104005. | |
| ML336 | ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613465-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12928. | |
| ML 337 | ML 337. Group: Biochemicals. Grades: Purified. CAS No. 1443118-44-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML339 | ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes β-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 μM and 1.4 μM, respectively. ML339 shows weaker activity against the recruitment of β-arrestin in mouse CXCR6 receptors, with an IC50 of 18 μM. ML339 has no inhibitory effect on CXCR5, CXCR4, CXCR6 and apelin receptor (APJ), with IC50 >79 μM. ML339 has the potential to promote the development of prostate cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2579689-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122197. | |
| ML 3403 | ML 3403. Group: Biochemicals. Grades: Purified. CAS No. 549505-65-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML345 | ML345 is a potent and selective inhibitor of insulin-degrading enzyme (IDE) and NLRP3, with an IC50 of 188 nM against IDE. ML345 targets the Cys819 residue of IDE to inhibit IDE. ML345 selectively binds to NLRP3 in a non-covalent manner. ML345 inhibits inflammatory cytokines (IL-1β, IL-6) and exhibits potent anti-inflammatory activity. ML345 exerts a protective effect against miscarriage[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1632125-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117878. | |
| ML346 | ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 100872-83-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18669. | |
| ML 347 | ML 347. Group: Biochemicals. Grades: Purified. CAS No. 1062368-49-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML348 | ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GNF-Pf-1127. CAS No. 899713-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100736. | |
| ML 348 | ML 348. Group: Biochemicals. Grades: Purified. CAS No. 899713-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML349 | ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 890819-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100737. | |
| ML 349 | ML 349. Group: Biochemicals. Grades: Purified. CAS No. 890819-86-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML351 | ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2[1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 847163-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111310. | |
| ML 354 | ML 354. Group: Biochemicals. Grades: Purified. CAS No. 89159-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML355 | ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 μM, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. Uses: Scientific research. Category: Signaling pathways. CAS No. 1532593-30-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-12341. | |
| ML364 | ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 μM) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 μM), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1991986-30-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100900. | |
| ML365 | ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM. ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 947914-18-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12345. | |
| ML375 | ML375 (VU0483253) is a potent, highly selective, brain-penetrant and orally active M5 mAChR negative allosteric modulator (NAM) with IC50s of 300 nM and 790 nM for human and rat M5, respectively. ML375 is inactive at human and rat M1-M4[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VU0483253. CAS No. 1488362-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12567. | |
| ML385 | ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins. Group: Inhibitors. CAS No. 846557-71-9. Pack Sizes: 5mg. Product ID: S8790. Formula: C29H25N3O4S. Smiles: CC1=CC=CC=C1C(=O)N2CCC3=C2C=CC(=C3)C4=C(SC(=N4)NC(=O)CC5=CC6=C(C=C5)OCO6)C. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| ML385 | ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 846557-71-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-100523. | |
| ML385 | ML385 Inhibitor. Uses: Scientific use. Product Category: T4360. CAS No. 846557-71-9. |  |
| ML390 | ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2029049-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100688. | |
| ML402 | ML402, a thiophene-carboxamide, is a selective K2P2.1(TREK-1) and K2P10.1(TREK-2) activator. ML402 is inactive against K2P4.1(TRAAK)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 298684-44-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104027. | |
| ML418 | ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker. ML418 inhibits Kir7.1 with an IC50 value of 0.31 μM. ML418 can be used for the research of neurological, cardiovascular, endocrine and muscle disorders. Uses: Scientific research. Category: Signaling pathways. CAS No. 1928763-08-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-122697. | |
| ML-60218 | ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 577784-91-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122122. | |
| ML 786 dihydrochloride | ML 786 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1237536-18-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML792 | ML-792 is a potent and selective inhibitor of SUMO (small ubiquitin-like modifier)-activating enzyme (SAE). ML-792 inhibits SAE/SUMO1 and SAE/SUMO2 in ATP-inorganic pyrophosphate (PPi) exchange assays with IC50 of 3 nM and 11 nM, respectively. Group: Inhibitors. CAS No. 1644342-14-2. Pack Sizes: 5mg. Product ID: S8697. Formula: C21H23BrN6O5S. Smiles: C1C(CC(C1COS(=O)(=O)N)O)NC2=NC=NC=C2C(=O)C3=NN(C=C3)CC4=CC(=CC=C4)Br. Storage Conditions: 3 years -20°C powder. | United States; Europe |
| ML-792 | ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1644342-14-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108702. | |
| ML 7 hydrochloride | ML 7 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 110448-33-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-7 hydrochloride | ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM). ML-7 hydrochloride also inhibits YAP/TAZ. Uses: Scientific research. Category: Signaling pathways. CAS No. 110448-33-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15417. | |
| ML-9 | ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity[3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively[1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 105637-50-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100932. | |
| ML 9 hydrochloride | ML 9 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 105637-50-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| M-LAURYL SULFATE BROTH | M-LAURYL SULFATE BROTH. Product ID: ACMA00006845. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| M-LAURYL SULFATE BROTH, VEGITONE | M-LAURYL SULFATE BROTH, VEGITONE. Product ID: ACMA00006846. Alfa Chemistry - ISO 9001:32057 Certified. | |
| MLCK inhibitor peptide | MLCK inhibitor peptide. Group: Biochemicals. Grades: Purified. CAS No. 198694-74-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18. Group: Biochemicals. Grades: Purified. CAS No. 224579-74-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MLCK inhibitor peptide 18 | A myosin light chain kinase (MLCK) inhibitor (IC50= 50 nM), and inhibits CaM kinase IIonly at 4000-fold higher concentrations. Synonyms: Myosin Light Chain Kinase Inhibitor Peptide 18. Grade: ≥95%. CAS No. 224579-74-2. Molecular formula: C60H105N23O11. Mole weight: 1324.64. |  |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Scientific research. Category: Signaling pathways. CAS No. 224579-74-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1029. | |
| MLCK inhibitor peptide 18 acetate | MLCK inhibitor peptide 18 acetate is a selective competitive myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM) that inhibits CaM kinase II only at 4000-fold higher concentrations. Synonyms: H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2.CH3CO2H; L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide acetate. Grade: ≥95%. Molecular formula: C62H109N23O13. Mole weight: 1384.67. | |
| MLH3 protein, partial (135-151) | MLH3 protein, partial (135-151) is a 7-aa peptide. MLH3 is a DNA mismatch repair gene associated with mammalian microsatellite instability. | |
| MLi-2 | MLi-2, a chemical probe, is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinsons disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1627091-47-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100411. | |
| MLKL-IN-6 | MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor targeting Mixed Lineage Kinase domain-like (MLKL). MLKL-IN-6 inhibits cell necrosis. MLKL-IN-6 inhibits MLKL phosphorylation and oligomerization during cell necrosis, inhibits immune cell death, and reduces the expression of adhesion factors. MLKL-IN-6 has low cytotoxicity, and it inhibits hepatic stellate cell activation, reduces liver fibrosis marker levels, and has anti-fibrotic effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3080148-24-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156119. | |
| MLKL Inhibitor, Necrosulfonamide ((E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide) | A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124nM and 2uM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. Group: Biochemicals. Grades: Highly Purified. CAS No. 432531-71-0. Pack Sizes: 25mg. Molecular Formula: C??H??N?O?S?, Primary Target: human MLKL. US Biological Life Sciences. | Worldwide |
| mlmp3 (D81N) | mlmp3 (D81N). Synonyms: Ala-Ala-Leu-Leu-Asn-Lys-Leu-Tyr-Ala. Molecular formula: C46H77N11O12. Mole weight: 976.23. | |
| MLN0905 | MLN0905 is a potent, orally active Polo-like kinase 1 (PLK1) inhibitor. MLN0905 has inhibitory potency against PLK1 with an IC50 value of 2 nM. MLN0905 can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1228960-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15155. | |
| MLN120B | MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML120B. CAS No. 783348-36-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15473. | |
| MLN120B dihydrochloride | MLN120B dihydrochloride (ML120B dihydrochloride) is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML120B dihydrochloride. CAS No. 1782573-78-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15473A. | |
| MLN2238 (Ixazomib) | Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3. Group: Inhibitors. CAS No. 1072833-77-2. Pack Sizes: 5mg. Product ID: S2180. Formula: C14H19BCl2N2O4. Smiles: B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MLN-4760 | MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM). Uses: Scientific research. Category: Signaling pathways. CAS No. 305335-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19414. | |
| MLN 4924 | A potent and selective inhibitor of NAE. Group: Biochemicals. Alternative Names: Sulfamic Acid [ (1S, 2S, 4R) -4- [4- [ [ (1S) -2, 3-dihydro-1H-inden-1-yl] amino] -7H-pyrrolo [2, 3-d] pyrimidin-7-yl] -2-hydroxycyclopentyl] methyl Ester. Grades: Highly Purified. CAS No. 905579-51-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences. | Worldwide |
| MLN4924 (Pevonedistat) | MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM. Group: Inhibitors. CAS No. 905579-51-3. Pack Sizes: 2mg. Product ID: S7109. Formula: C21H25N5O4S. Smiles: C1CC2=CC=CC=C2C1NC3=C4C=CN(C4=NC=N3)C5CC(C(C5)O)COS(=O)(=O)N. Storage Conditions: 2 years -80 in solvent. | United States; Europe |
| MLN8054 | MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC50 of 4 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 869363-13-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10180. | |
| MLN 8054 | An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic Acid. Grades: Highly Purified. CAS No. 869363-13-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| MLN 8237 | Antagonist of Aurora A serine/threonine protein kinase; antineoplastic. Group: Biochemicals. Alternative Names: 4-[[9-Chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid; Alisertib. Grades: Highly Purified. CAS No. 1028486-01-2. Pack Sizes: 10mg. Molecular Formula: C27H20ClFN4O4, Molecular Weight: 518.92. US Biological Life Sciences. | Worldwide |
| MLR 1023 | MLR 1023. Group: Biochemicals. Grades: Purified. CAS No. 41964-07-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| mLR12 | mLR12 is a Trem1 inhibitory peptide. mLR12 decreases aortic rupture rate in BAPN-induced Thoracic aortic aneurysm and dissection (TAAD) mice model[1]. Uses: Scientific research. Category: Peptides. CAS No. 3033299-76-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P5521. | |
| MLR-52 | MLR-52, extracted from Streptomyces sp. AB 1869R-359, is an immunosuppressive protein kinase C inhibitor. And the IC50 (nmol/L) of the mixed lymphocyte response test was 1.9±0.2. Synonyms: 4'-Demethylamino-4',5'-dihydroxystaurosporine; (+)-MLR-52. CAS No. 155416-34-5. Molecular formula: C27H23N3O5. Mole weight: 469.49. | |
| MLS000532223 | MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 16616-39-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117149. | |
| MLS000536924 | MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 511306-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116919. | |
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