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| Product | Description | |
|---|---|---|
| MK-886 sodium salt | MK-886 sodium salt. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C27H33ClNNaO2S. US Biological Life Sciences. |  Worldwide |
| MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886) | MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886). Group: Biochemicals. Alternative Names: Sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 25mg. Molecular Formula: C27 H33 ClNO 2 , Molecular Weight: 494.1. US Biological Life Sciences. | Worldwide |
| MKC3946 | MKC3946 is a potent IRE1α inhibitor, used for cancer research. Uses: Scientific research. Category: Signaling pathways. CAS No. 1093119-54-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19710. |  |
| MKC8866 | MKC8866 Inhibitor. Uses: Scientific use. Product Category: T15594. CAS No. 1338934-59-0. |  |
| MKC8866 | MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50 of 0.14 μM[1]. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Orin1001. CAS No. 1338934-59-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104040. | |
| MKI-1 | MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MASTL Kinase Inhibitor-1. CAS No. 1190277-80-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-137552. | |
| MKK7-COV-9 | MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein-protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC50 of 4.98 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2283355-59-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122872. | |
| MKK7-JNK activator 1 | MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator. MKK7-JNK activator 1 effectively inhibits the proliferation and migration of MDA-MB-468 cells, induces G2/M phase arrest and caspase -dependent apoptosis (independent of ROS production). MKK7-JNK activator 1 significantly increases the levels of p-MKK7 and p-JNK, but does not affect p-ERK or p-p38. MKK7-JNK activator 1 can be used for the study of triple-negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3100092-62-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-179044. | |
| MKT 077 | MKT-077 is used in the treatment of Alzheimers diseases and other tauopathies. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2; selectively cytotoxic in cancer cells.Biological Activity:Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Group: Biochemicals. Alternative Names: 1-Ethyl-2- [ [3-ethyl-5- (3-methyl-2 (3H) -benzothiazolylidene) -4-oxo-2-thiazolidinylidene] methyl] -pyridinium Chloride; FJ 776. Grades: Highly Purified. CAS No. 147366-41-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?OS??; Ci, Molecular Weight: 441.01. US Biological Life Sciences. | Worldwide |
| MKT-077 | MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity[1]. MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FJ-776. CAS No. 147366-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15096. | |
| ML00253764 | ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 681847-92-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124740. | |
| ML 00253764 hydrochloride | ML 00253764 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-00253764 hydrochloride | ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. ML-00253764 can cross blood-brain barrier[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1706524-94-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110123. | |
| ML-030 | ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1013750-77-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103050. | |
| ML089 | ML089 is a potent, selective, and orally available phosphomannose isomerase (PMI) inhibitor with an IC50 of 1.3 μM. ML089 can be used for the research of congenital disorder of glycosylation Ia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1306638-12-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138802. | |
| ML-098 | ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-7345532. CAS No. 878978-76-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19800. | |
| ML-099 | ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-888706. CAS No. 496775-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124306. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 186826-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML115 | ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC50 of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 912798-42-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111152. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 130 | ML 130. Group: Biochemicals. Grades: Purified. CAS No. 799264-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML132 | ML132 (NCGC-00183434) is a selective caspase 1 inhibitor with an IC50 value of 0.023 nM. ML132 has good stability and can be used as a caspase 1 molecular probe. ML132 is applicable to research in the fields of anticancer and anti-inflammatory studies[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NCGC-00183434. CAS No. 1230628-71-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12412. | |
| ML 133 hydrochloride | ML 133 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1222781-70-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML133 hydrochloride | ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1222781-70-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100230A. | |
| ML141 | ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-2950007. CAS No. 71203-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-12755. | |
| ML 141 | ML 141. Group: Biochemicals. Grades: Purified. CAS No. 71203-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145. Group: Biochemicals. Grades: Purified. CAS No. 1164500-72-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM)[1]. ML 145 has no significant activity for GPR35 at either rodent ortholog[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164500-72-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107536. | |
| ML154 | ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NCGC84. CAS No. 1345964-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108626. | |
| ML 154 | ML 154. Group: Biochemicals. Grades: Purified. CAS No. 1345964-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 161 | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. Group: Biochemicals. Alternative Names: ML161; 2-Bromo-N- [3- [ (1-oxobutyl) amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 423735-93-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML162 | ML162 Inhibitor. Uses: Scientific use. Product Category: T8970. CAS No. 1035072-16-2. | |
| ML162 | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1035072-16-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-100002. | |
| ML167 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID44968231; NCGC00188654. CAS No. 1285702-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15951. | |
| ML 171 | ML 171. Group: Biochemicals. Grades: Purified. CAS No. 6631-94-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| ML179 | ML179 (SR-1309) is a inverse LRH1/NR5A2 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883548-87-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110329. | |
| ML 179 | ML 179. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-180 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115613. | |
| ML 190 | ML 190. Group: Biochemicals. Grades: Purified. CAS No. 1355244-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-193 | ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinsons disease (PD) rats[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID 1261822. CAS No. 713121-80-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110125. | |
| ML198 | ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1380716-06-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117861. | |
| ML 202 | ML 202. Group: Biochemicals. Grades: Purified. CAS No. 1221186-52-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML 204 | ML 204. Group: Biochemicals. Grades: Purified. CAS No. 5465-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 204 (Selective TRPC4 Blocker, 4-Methyl-2-(1-piperidinyl)quinoline ) | Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6um in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22um. Group: Biochemicals. Grades: Highly Purified. CAS No. 5465-86-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML-210 | ML-210 (CID 49766530) is a selective covalent inhibitor of cellular glutathione peroxidase 4 (GPX4) with EC50 of 0.04 μM and induces ferroptosis. ML-210 can selectively kill cells induced to express mutant RAS. ML-210 exhibits anti-cancer activity. Group: Inhibitors. Alternative Names: CID 49766530. CAS No. 1360705-96-9. Pack Sizes: 5mg. Product ID: S0788. Formula: C22H20Cl2N4O4. Smiles: CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]. Storage Conditions: 3 years -20°C powder. |  United States; Europe |
| ML-210 | ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1360705-96-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100003. | |
| ML-211 | ML-211 is a potent dual inhibitor of LYPLA1 and LYPLA2 enzymes, with an IC50 value of 17 nM against LYPLA1, 30 nM against LYPLA2, and 10 nM against ABHD11[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2205032-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128035. | |
| ML213 | ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 489402-47-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101843. | |
| ML 213 | ML 213. Group: Biochemicals. Grades: Purified. CAS No. 489402-47-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML216 | ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 μM. Antitumor avtivity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-49852229. CAS No. 1430213-30-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12342. | |
| ML218 | ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346233-68-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103309. | |
| ML 218 hydrochloride | ML 218 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1346233-68-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML221 | ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays. Uses: Scientific research. Category: Signaling pathways. CAS No. 877636-42-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103254. | |
| ML 221 | ML 221. Group: Biochemicals. Grades: Purified. CAS No. 877636-42-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-?226 | ML226 is a potent α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor in vitro and in situ with IC50s of 15 and 0.68 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055172-43-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129121. | |
| ML228 | ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CID-46742353. CAS No. 1357171-62-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12754. | |
| ML 228 | ML 228. Group: Biochemicals. Grades: Purified. CAS No. 1357171-62-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML233 | ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2080311-92-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-125976. | |
| ML 236A | It has the activity of inhibiting HMG-CoA reductase, and it is produced by the strain of Penicillum citrinum SANK. Synonyms: Compactin diol lactone; ML-236A; 6-(2-(1,2,6,7,8,8a-Hexahydro-8-hydroxy-2-methyl-1-naphthalenyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one; desmethylmonacolin J; Antibiotic ML 236A. CAS No. 58889-19-3. Molecular formula: C18H26O4. Mole weight: 306.40. |  |
| ML240 | ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346527-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19795. | |
| ML 240 | ML 240. Group: Biochemicals. Grades: Purified. CAS No. 1346527-98-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML241 | ML241 is a potent, selective and competitive p97 ATPase inhibitor with an IC50 of 0.11 μM. ML241 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346528-06-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19797. | |
| ML243 (Cancer Stem Cell Inhibitor, ML243, (E) -N- (4, 5-Dihydrothiazol-2-yl) -3- (4-ethylphenyl) acrylamide, (2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)prop-2-enamide) | A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog that selectively exerts an inhibitory effect on breast cancer stem-like cells (EC50 = 2uM for epithelial-to-mesenchymal transition; HMLE_shEcad). Exhibits ~32-fold greater selectivity over isogenic control cells (EC50 = 64uM; HMLE cell line expressing shRNA against eGFPcells; HMLE_sh_eGFP). Displays desirable aqueous solubility (~11.5uM in PBS, pH 7.4) and excellent stability in human plasma and in glutathione solution. Shown to block the binding to a radio-labeled ligand to the Adenosine A2A Receptor (IC50 = 10uM), but does not affect 68 other targets studied. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| ML252 | ML252 is a selective inhibitor of KCNQ2 (Kv7.2) channel with an IC50s of 69 nM, 2.92 μM, 0.12 μM and 0.20 μM for KCNQ2, KCNQ1 (Kv7.1), KCNQ2/Q3 and KCNQ4, respectively. ML252 also inhibits Cytochrome P450 with IC50s of 6.1 nM (CYP1A2), 18.9 nM (CYP2C9), 3.9 nM (CYP3A4), 19.9 nM (CYP2D6), respectively. ML252 shows highly brain penetrant [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1392494-64-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18063. | |
| ML264 | ML264 is an antitumor agent that potently and selectively inhibits Krüppel-like factor five (KLF5) expression. Uses: Scientific research. Category: Signaling pathways. CAS No. 1550008-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19994. | |
| ML 277 | ML 277. Group: Biochemicals. Grades: Purified. CAS No. 1401242-74-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML281 | ML281 is a highly selective inhibitor of serine/threonine kinase 33 (STK33) with an IC50 value of 14 nM. ML281 shows 700-fold selectivity over PKA and 550-fold over AurB. ML281 exerts core mechanism by inhibiting STK33: in small cell lung cancer, ML281 downregulates RPS6/BAD signaling phosphorylation, induces apoptosis, and suppresses proliferation, invasion[1]. ML281 reduces STK33-mediated 4-hydroxyphenylpyruvate dioxygenase (HPD) phosphorylation in tyrosinemia [4]. ML281 is suitable for research on STK33 function, KRAS mutation-related cancers (pancreatic cancer, colon cancer, lung adenocarcinoma, etc.), small cell lung cancer, and tyrosinemia-related damage[1][2][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1404437-62-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13495. | |
| ML 281 | ML 281. Group: Biochemicals. Grades: Purified. CAS No. 1404437-62-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 289 | ML 289. Group: Biochemicals. Grades: Purified. CAS No. 1382481-79-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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