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| Product | Description | |
|---|---|---|
| PROTAC GPX4 degrader-4 | PROTAC GPX4 degrader-4 is a GPX4 PROTAC degrader (DC50: 5.32 nM). PROTAC GPX4 degrader-4 inhibits the activity of RT4, T24, and J82 cancer cells (IC50 values are 0.09, 2.97, and 7.58 μM, respectively). PROTAC GPX4 degrader-4 increases lipid ROS levels and induces ferroptosis in T24 and RT4 cells. PROTAC GPX4 degrader-4 has antitumor activity in T24 tumor-bearing BALB/c nude mouse model. PROTAC GPX4 degrader-4 can be used for bladder cancer research. (Pink: target protein ligand (HY-N0193); blue: E3 ligase ligand (HY-1035960); black: linker (HY-W013907); E3 ligase ligand + linker (HY-174087))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3071165-43-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-174086. |  |
| PROTAC GSK-3β Degrader-1 | PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β degradation with an IC50 value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ25-35 peptide and CuSO4. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3093409-30-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-149845. | |
| PROTAC Her3 Degrader-8 | PROTAC Her3 Degrader-8 (Compound PP2) is a Her3 PROTAC degrader. PROTAC Her3 Degrader-8 promotes the ubiquitination and degradation of Her3. PROTAC Her3 Degrader-8 can be used in the study of lung adenocarcinoma and ovarian cancer (Pink: Her3 ligand (HY-107450); Blue: E3 ligase ligand (HY-170861); Black: linker (HY-Y1760))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2103331-95-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153796. | |
| PROTAC HK2 Degrader-1 | PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033812-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155008. | |
| PROTAC HSP90 degrader BP3 | PROTAC HSP90 degrader BP3 is a potent and selective degradation of HSP90 in a CRBN-dependent fashion. PROTAC HSP90 degrader BP3 has a certain degradation effect on HSP90 protein in MCF-7 cells (DC50=0.99 μM). PROTAC HSP90 degrader BP3 inhibits the growth of breast cancer cell[1]. PROTAC HSP90 degrader BP3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2669072-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115997. | |
| PROTAC IDO1 Degrader-1 | PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488851-89-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131911. | |
| PROTAC JAK1 degrader 1 | PROTAC JAK1 degrader 1 is a JAK1 PROTAC degrader with a DC50 of 214 nM and an IC50 of 5.2 nM. PROTAC JAK1 degrader 1 inhibits the downstream JAK-STAT signaling pathway by degrading JAK1. PROTAC JAK1 degrader 1 exhibits antiproliferative activity in cells. PROTAC JAK1 degrader 1 can be used for research on leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052553-20-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-162608. | |
| PROTAC KDM3 degrader-1 | PROTAC KDM3 degrader-1 (Compound 4) is a CRBN-recruiting PROTAC designed based on the IOX1 (HY-12304) scaffold. PROTAC KDM3 degrader-1 selectively degrades the KDM3A and KDM3B proteins, thereby inhibiting the Wnt/β-catenin signaling pathway. PROTAC KDM3 degrader-1 significantly suppresses the self-renewal capacity of colorectal cancer stem cells and inhibits the growth of colorectal cancer tumors. PROTAC KDM3 degrader-1 is suitable for research on colorectal cancer (Target protein ligand (Pink): HY-12304; linker (Black): HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue): HY-41547)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3119090-33-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168593. | |
| PROTAC K-Ras Degrader-1 | PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC. PROTAC K-Ras Degrader-1 can effectively degrades K-Ras based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2378258-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-129523. | |
| PROTAC K-Ras Degrader-1 | PROTAC K-Ras Degrader-1 is potent K-Ras degrader based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells. Alternative Names: PROTAC K-Ras Degrader-1; 2378258-52-5; 2-[(2S)-4-[2-[[(2S,4R)-4-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]-1-methylpyrrolidin-2-yl]methoxy]-7-naphthalen-1-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile; SCHEMBL21459082; EX-A3964; AKOS040740885; MS-31852; HY-129523; CS-0106329; 2-((2S)-1-acryloyl-4-(2-(((2S,4R)-4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)-1-methylpyrrolidin-2-yl)methoxy)-7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazin-2-yl)acetonitrile. Grades: 98%. CAS No. 2378258-52-5. Molecular formula: C53H62N10O10. Mole weight: 999.12. |  |
| PROTAC K-Ras Degrader-3 | PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC50 of ≤ 1 nM against SW620 KRAS G12D, and a GI50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research, such as non-small-cell lung cancer (NSCLC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3043670-68-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168054. | |
| PROTAC K-Ras Degrader-4 | PROTAC K-Ras Degrader-4 (Compound 4) is a PROTAC degrader for KRAS that degrades KRASG12D in GP5d and degrades KRASG12V in cell SW620 with DC50s of 1 nM and 13 nM. PROTAC K-Ras Degrader-4 inhibits MAPK signaling pathway[1]. (Pink: ligand for target protein pan-KRAS degrader 1 (HY-162960); Black: linker (HY-159790); Blue: ligand for E3 ligase VHL (HY-W998248)). Uses: Scientific research. Category: Signaling pathways. CAS No. 2938169-99-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159788. | |
| PROTAC KRAS G12C degrader-1 | PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2984236-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139186. | |
| PROTAC KRAS G12D degrader 1 | PROTAC KRAS G12D degrader 1 is a selective PROTAC KRASG12D degrader. PROTAC KRAS G12D degrader 1 inhibits proliferation of KRASG12D-mutant cells and suppresses ERK phosphorylation. PROTAC KRAS G12D degrader 1 inhibits tumor growth in mice bearing AsPC-1 xenografts. PROTAC KRAS G12D degrader 1 can be used for the study of KRASG12D-driven cancers.(Pink: KRAS ligand (HY-175892), Blue: VHL Ligand (HY-112078), Black: Linker, E3 ligase ligand-linker conjugate (HY-175893))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033583-54-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161176. | |
| PROTAC Mcl1 degrader-1 | PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2163793-38-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125877. | |
| PROTAC MDM2 Degrader-2 | PROTAC MDM2 Degrader-2 is an MDM2 PROTAC degrader. PROTAC MDM2 Degrader-2 can induce the self-ubiquitination and degradation of MDM2, thereby upregulating the level of p53 protein. PROTAC MDM2 Degrader-2 has anti-tumor activity and can be used in the study of cancer[1]. (Blue: MDM2 ligand (HY-128836); Black: linker (HY-128833)). Uses: Scientific research. Category: Signaling pathways. CAS No. 2249944-99-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-128841. | |
| PROTAC MLKL Degrader-1 | PROTAC MLKL Degrader-1 is a selective MLKL PROTAC degrader with a DC50 of 2.4 μM. PROTAC MLKL Degrader-1 blocks necroptosis without modulating the phosphorylation of RIPK1 or RIPK3, and exhibits a linear correlation between MLKL levels and necroptotic cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032600-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156591. | |
| PROTAC MNK1 degrader-1 | PROTAC MNK1 degrader-1 is a selective MNK1 PROTAC degrader with a DC50 of 11.92 nM, and a Dmax > 96% in MV4-11 cells. PROTAC MNK1 degrader-1 significantly reduces p-eIF4E (IC50: 22.07 nM), induces apoptosis, and arrests the cell cycle at the G1 phase. PROTAC MNK1 degrader-1 has potent antitumor activity. PROTAC MNK1 degrader-1 has robust antileukemic efficacy in MV4-11 xenograft mice model with acceptable drug safety[1]. Pink: MNK1 ligand (HY-176429); Blue: CRBN ligase ligand (HY-A0003); Black: linker (HY-Y1139); CRBN + linker: HY-176430. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P11-2. CAS No. 3120743-91-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176428. | |
| PROTAC NCOA4 degrader-1 | PROTAC NCOA4 degrader-1 is a VHL-based PROTAC NCOA4 degrader. PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. PROTAC NCOA4 degrader-1 reduces Fe2+ elevation, ROS production, MDA content and PTGS2 mRNA expression. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model. PROTAC NCOA4 degrader-1 can be used for the researches of inflammation and immunology. (Pink: NCOA4 ligand (HY-149457). Black: linker (HY-163903). Blue: VHL ligand (HY-138678B))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3098187-24-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-163897. | |
| PROTAC PARP1 degrader-1 | PROTAC PARP1 degrader-1 is a PARP1 PROTAC degrader with a DC50 value of 252.5 nM. PROTAC PARP1 degrader-1, combined with Daunorubicin (HY-13062A), induces the accumulation of cytoplasmic DNA fragments, activates the cGAS/STING innate immune pathway, and remodels the tumor microenvironment. PROTAC PARP1 degrader-1 can be used in research related to breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032324-56-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-158045. | |
| PROTAC PD-1/PD-L1 degrader-1 | PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2447066-37-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131183. | |
| PROTAC PD-L1 degrader-1 | PROTAC PD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with a notable PD-L1 protein degradation capability. PROTAC PD-L1 degrader-1 shows potent PD-L1 degradation in 4T1 cells with a DC50 of 0.609 μM. PROTAC PD-L1 degrader-1 can be used for the study of breast cancer. (Blue: CRBN ligand (HY-150839), Black: linker; Pink: PD-L inhibitor (HY-19745))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052114-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-163757. | |
| PROTAC PD-L1 degrader-2 | PROTAC PD-L1 degrader-2 is a PD-L1 PROTAC degrader with an IC50 of 197.4 nM and a Kd of 301 nM. PROTAC PD-L1 degrader-2 induces PD-L1 endocytosis, drives degradation via the proteasomal and lysosomal pathways, and inhibits the PD-1/PD-L1 interaction. As an immune activator, PROTAC PD-L1 degrader-2 increases the levels of CD4+, CD8+, granzyme B and perforin. PROTAC PD-L1 degrader-2 can be used in studies related to colon cancer immunology[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2995357-09-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162972. | |
| PROTAC PIN1 degrader-1 | PROTAC PIN1 degrader-1 is a PIN1-target PROTAC degrader. PROTAC PIN1 degrader-1 TFA can be used for the research of triple-negative breast cancer, pancreatic cancer, and liver cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3038591-59-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168037. | |
| PROTAC RIPK degrader-2 | PROTAC RIPK degraders -2 is a non-peptide PROTAC based on von Hippel-Lindau and targets serine-threonine kinase RIPK2, which is highly selective to the degradation of RIPK2. PROTAC RIPK degrader-2 acts as an activator to increase cell death and activate ion channels in cancer cells. PROTAC RIPK degrader-2 also can inhibit protein interactions, such as receptors and ligands, involved in a variety of diseases, such as cancer and diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1801547-16-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111866. | |
| PROTAC RIPK degrader-6 | PROTAC RIPK degrader-6 (example 1) is a Cereblon-based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089205-64-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-111870. | |
| PROTAC SGK3 degrader-1 | PROTAC SGK3 degrader-1 (SGK3-PROTAC1), a chemical probe, is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SGK3-PROTAC1. CAS No. 2381320-35-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125878. | |
| PROTAC Sirt2 Degrader-1 | PROTAC Sirt2 Degrader-1 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide. PROTAC Sirt2 Degrader-1 led a selective and dose-dependent degradation of Sirt2 at concentration ranging in 0.2-5μM, as well as a time-dependent depletion of Sirt2 at concentration of 10μM post 0.5-2h with a max degradation observed at 2h in HeLa cells. Depletion of Sirt2 by PROTAC Sirt2 Degrader-1 at concentration of 10μM resulted in a more pronounced acetylation of the microtubule network with enhanced process elongation than enzymatic Sirt2 inhibition. Alternative Names: Sirt2-PROTAC-1; Sirt2 PROTAC-1; Sirt2-PROTAC1; Sirt2 PROTAC 1; N-[4-[4-[[3-[[2-[[2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetyl]amino]-1,3-thiazol-5-yl]methyl]phenoxy]methyl]triazol-1-yl]butyl]-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide. CAS No. 2098487-75-1. Molecular formula: C40H40N10O8S2. Mole weight: 852.94. | |
| PROTAC Sirt2 Degrader-1 | PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2098487-75-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103636. | |
| PROTAC SMARCA2/4 degrader-38 | PROTAC SMARCA2/4 degrader-38 is a degrader SMARCA2/4 PROTAC (DC50: 3.0 nM and 4.0 nM respectively). PROTAC SMARCA2/4 degrader-38 promotes the ubiquitination and degradation of SMARCA2/4. PROTAC SMARCA2/4 degrader-38 blocks the G0/G1 cell cycle and induces apoptosis. PROTAC SMARCA2/4 degrader-38 can be used in acute myeloid leukemia (AML) research. (Pink: SMARCA2/4 ligand; Blue: VHL ligand (HY-112078); Black: linker; Target Protein Ligand-Linker Conjugates (HY-173343))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3081688-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173333. | |
| PROTAC SMARCA2 degrader-8 | PROTAC SMARCA2 degrader-8 (compound 1) is a potent SMARCA2 degrader with a DC50 of 28nM in A375 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2669027-50-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161882. | |
| PROTAC STAT6 degrader-1 | PROTAC STAT6 degrader-1 (Compound I-2) is a potent STAT6 PROTAC degrader with a DC50 <1 nM. PROTAC STAT6 degrader-1 inhibits STAT6 activity with an IC50 of <0.1 pM. PROTAC STAT6 degrader-1 can be used for inflammatory and cancers research, such as non-small cell lung cancer (NSCLC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3077464-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-176857. | |
| PROTAC STING Degrader-1 | PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway with a DC50 of 3.2 μM. PROTAC STING Degrader-1 exerts high anti-inflammatory efficacy. PROTAC STING Degrader-1 can be used to study diseases such as acute kidney injury and inflammatory bowel diseases (IBDs). (Pink: STING ligand (HY-138682); Blue: CRBN ligand (HY-10984); Black: linker (HY-W015883))[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2762552-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150608. | |
| PROTAC STING degrader-3 | PROTAC STING degrader-3 is a STING PROTAC degrader (DC50: 0.62 μM). PROTAC STING degrader-3 induces STING degradation via the ubiquitin-proteasome pathway. PROTAC STING degrader-3 exerts anti-inflammatory effects by inhibiting STING/TBK1/NF-κB signaling. PROTAC STING degrader-3 has renal protective effects and can be used in the study of acute kidney injury (AKI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3109967-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-173414. | |
| PROTAC TBK1 degrader-2 | PROTAC TBK1 degrader-2 is a Ligands for Target Protein for PROTAC. PROTAC TBK1 degrader-2 is a potent degrader based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) (DC50=15 nM; Kd=4.6 nM) with a maximum efficiency of 96%. PROTAC TBK1 degrader-2 also targets to IkB kinase IKKε (IC50=8.7 nM), with low selectivity over TBK1 (IC50=1.3 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2052306-13-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-112557. | |
| PROTAC TEAD degrader-1 | PROTAC TEAD degrader-1 is a TEAD2 degrader and antiproliferative agent with selective activity toward TEAD2 relative to other TEAD family members. PROTAC TEAD degrader-1 relies on CRBN and the proteasome system for TEAD2 degradation; disruption of CRBN binding attenuates this activity. PROTAC TEAD degrader-1 decreases expression of YAP target genes CYR61 and CTGF. PROTAC TEAD degrader-1 can be used for the research of NF2-deficient cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3061498-57-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-158342. | |
| PROTAC XPO1 degrader-1 | PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. PROTAC XPO1 degrader-1 exhibits anti-proliferative effects, can induce cell apoptosis, inhibit NF-κB activity, and cause cell cycle arrest in the G1 phase. PROTAC XPO1 degrader-1 can be used in research on hematological malignancies (Pink: Target Protein Ligand (HY-170672); Black: Linker (HY-W010525); Blue: E3 Ligase Ligand (HY-170671); E3 Ligase Ligand-Linker Conjugate (HY-170673))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3105680-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-170669. | |
| PROTAC YAP degrader-1 | PROTAC YAP degrader-1 is a VHL-recruiting PROTAC degrader (DC50=8.2 μM) and antiproliferative agent that targets YAP. PROTAC YAP degrader-1 recruits the E3 ligase VHL and binds to VHL to form a ternary complex containing YAP. PROTAC YAP degrader-1 inhibits the nuclear localization of YAP in cancer cells, reduces YAP/TEAD-mediated transcription, and induces TAZ protein degradation. PROTAC YAP degrader-1 reduces the oncogenic activity of YAP and exerts antiproliferative effects in the Huh7 xenograft mouse model. PROTAC YAP degrader-1 can be used for the research of hepatocellular carcinoma and mesothelioma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3058483-58-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168016. | |
| proTAME | proTAME, a cell-permeable proagent form of TAME, is an anaphase promoting complex/cyclosome (APC/C) inhibitor. proTAME causes cell cycle arrest in metaphase[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1362911-19-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124955. | |
| Protamine sulfate | Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer[1][2][3]. Uses: Scientific research. Category: Induced disease models products. CAS No. 9009-65-8. Pack Sizes: 100 mg; 200 mg. Product ID: HY-107911. | |
| Protamine sulfate | Protamine sulfate is used as an antidote against the anticoagulant effects of negatively charged heparin, for example in heart surgery. Alternative Names: Protamines, sulfates; Novo protamine sulfate; Protamine sulfates. CAS No. 9009-65-8. | |
| Protamine Sulfate | Antiheparin drugs. Category: Active pharmaceutical ingredients. CAS No. 98001-69-5. Product ID: API98001695. Molecular formula: C20H22N8O5. Mole weight: 454.43. Standard: Chinese Pharmacopoeia 2015 Edition Part 2. |  |
| Protamine sulfate salt | Protamine sulfate salt. Group: Biochemicals. Alternative Names: Salmine Sulfate. Grades: Highly Purified. CAS No. 53597-25-4. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences. |  Worldwide |
| Protamine sulfate salt Salmon | Protamine sulfate salt Salmon. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g, 250g. US Biological Life Sciences. | Worldwide |
| Protease | Protease. CAS No. 9036-06-0. | |
| Protease 5,000 HUT/g & 200,000 HUT/g & 500,000 HUT/g | Protease 5,000 HUT/g & 200,000 HUT/g & 500,000 HUT/g. |  CA, FL & NJ |
| Protease-Activated Receptor-1, PAR-1 Agonist | Protease-Activated Receptor-1, PAR-1 Agonist is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 141136-85-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2518. | |
| Protease-Activated Receptor-2 Activating Peptide | LIGRL-NH2 is a PAR2 activator with EC50 value of ~5 μM. It can be used to explore signaling through PAR2 in cells. Alternative Names: Thrombin Receptor-Like 1 (1-6) amide (mouse, rat); SLIGRL amide; Proteinase Activated Receptor 2 (1-6) amide (mouse, rat); Coagulation Factor II Receptor-Like 1 (1-6) amide (mouse, rat); PAR-2 (1-6) amide (mouse, rat); Ser-Leu-Ile-Gly-Arg-Leu-NH2; L-Seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucinamide. Grades: 98%. CAS No. 171436-38-7. Molecular formula: C29H56N10O7. Mole weight: 656.82. | |
| Protease-Activated Receptor-2, amide | Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. Uses: Scientific research. Category: Signaling pathways. CAS No. 190383-13-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0283. | |
| Protease-Activated Receptor-2, amide | SLIGKV-NH2 is a protease-activated receptor 2 (PAR2) agonist (Ki = 9.64 μM; IC50 = 10.4 μM). Alternative Names: Thrombin Receptor-Like 1 (1-6) amide (human); SLIGKV amide; Proteinase Activated Receptor 2 (1-6) amide (human); Coagulation Factor II Receptor-Like 1 (1-6) amide (human); Ser-Leu-Ile-Gly-Lys-Val; PAR2 activating peptide; PAR2-AP; PAR-2 (1-6) Human; L-seryl-L-leucyl-L-isoleucyl-glycyl-L-lysyl-L-valinamide. Grades: 98%. CAS No. 190383-13-2. Molecular formula: C28H54N8O7. Mole weight: 614.78. | |
| Protease-Activated Receptor-4 | Protease-Activated Receptor-4 is an agonist of proteinase-activated receptor-4 (PAR4). Alternative Names: PAR-4 (1-6) amide (mouse); H-Gly-Tyr-Pro-Gly-Lys-Phe-NH2; glycyl-L-tyrosyl-L-prolyl-glycyl-L-lysyl-L-phenylalaninamide. Grades: ≥95%. CAS No. 245443-52-1. Molecular formula: C33H46N8O7. Mole weight: 666.77. | |
| Protease-Activated Receptor-4 | Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4). Uses: Scientific research. Category: Signaling pathways. CAS No. 245443-52-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0297. | |
| Protease enzyme for fermentation | A protease enzyme used in food processing applications to break down and increase the solubility, dispersability, palatability and digestibility of proteins. Applications: Fermentation enhancement. Group: Enzymes. Synonyms: Protease enzyme; for fermentation; protease; Fuel Alcohol; Alcohol and Starch Enzymes; Fermentation enhancement; enhancement; Starch Enzymes. CAS No. 37259-58-8. Protease. Appearance: inquire. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: ASE-3112. |  |
| Protease for baking | A protease enzyme used to produce food-protein hydrolysates with reduced viscosity, improved solubility, flavor, nutritional, and emulsifying characteristics. Applications: For biscuits and crackers. Group: Enzymes. Synonyms: Protease for baking; granulated protease enzyme; For Biscuits and Crackers; BAK-1723. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: BAK-1723. | |
| Protease for flavors | Protease used in a neutral to alkaline environment. Used to develop savory flavors and to debitter protein hydrolysates. Applications: Flavors in high-protein flours used in baking. Group: Enzymes. CAS No. 37259-58-8. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: PRO-1827. | |
| Protease for Medical | Protease enzyme used in medical and surgical instrument cleaning products to remove protein-containing, organic materials such as blood, mucus, feces and foods. Applications: Laundry. Group: Enzymes. Synonyms: Protease; Medical and surgical instrument; cleaning; Protease enzyme; surgical instrument; Detergents; Protease for Medical; DETE-2630. CAS No. 37259-58-8. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: DETE-2630. | |
| Protease for special flours | A protease enzyme for the treatment of special flours for biscuit and cracker making, which require low-protein levels. Applications: For biscuits and crackers. Group: Enzymes. Synonyms: Protease for special flours; protease enzyme; For Biscuits and Crackers; BAK-1722. Protease. Appearance: powder or liquid. Acid Protease; for beer; Acid Protease; ethanol; baijiu Enzyme; beer Enzyme; brewage Enzyme; Acid Protease for beer; BER-1512. Pack: 25kg/paper barrel (powder form), 30kg/polyster barrel (liquid form). Cat No: BAK-1722. | |
| Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Protease Inhibitor Cocktail comprehensively protects proteins from degradation by a variety of proteases. Provided at 100X in an EDTA-free, DMSO solution, it is ready to use. Group: Kits. Pack Sizes: 1 mL. Product ID: B14001. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. |  United States; Europe |
| Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Protease Inhibitor Cocktail comprehensively protects proteins from degradation by a variety of proteases. Provided at 100X in an EDTA-free, DMSO solution, it is ready to use. Group: Kits. Pack Sizes: 1 mL x 10. Product ID: B14002. Storage Conditions: 3 years-20°C powder 2 years-80°C in solvent. | United States; Europe |
| Protease Inhibitor Library | A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening; - Targets include proteasome, DPP-4, Serine protease, cysteine protease, MMP, Aspartic proteinases, etc; - Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L1100. Categories: Protease Inhibitor Libraries. |  |
| Protease-polyethylene glycol | A protease (also called peptidase or proteinase) is any enzyme that performs proteolysis, that is, begins protein catabolism by hydrolysis of the peptide bonds that link amino acids together in a polypeptide chain. Proteases have evolved multiple times, and different classes of protease can perform the same reaction by completely different catalytic mechanisms. Proteases can be found in animals, plants, bacteria, archaea and viruses. Group: Enzymes. Synonyms: PEG-Subtilisin Carlsberg; Protease-polyethylene glycol; Protease-PEG. Protease. Activity: ~600 BAEE units/mg protein. Storage: -20°C. Form: lyophilized powder. PEG-Subtilisin Carlsberg; Protease-polyethylene glycol; Protease-PEG. Pack: Package size based on protein content. Cat No: NATE-0635. | |
| Protease S from Pyrococcus furiosus, Recombinant | Protease S is a serine endoprotease with broad specificity that will digest native and denatured proteins. Cleavage occurs mainly on the carboxy side of peptide bonds. The optimal temperature range is 85 to 95°C and the optimal pH range is 6.0 to 8.0. Protease S is inhibited by PMSF. Thermostable serine protease with broad specificity for native and denatured proteins. Applications: Protease s is from pyrococcus furiosus and is a recombinant protease that is expressed in bacillus sp. it is used for fragmentation of proteins and peptides required for primary structure analysis. Group: Enzymes. Synonyms: Protease S; peptidase S; proteinase S. Protease. Storage: 2-8°C. Form: Solution in 25 mM Tris-HCl, pH 7.6, containing 40% ethanol. Source: Bacillus sp. Species: Pyrococcus furiosus. Protease S; peptidase S; proteinase S. Cat No: NATE-0630. | |
| Protease type viii bacterial | Protease type viii bacterial. Grades: 95%. CAS No. 9014-1-1. | |
| proteasome ATPase | Belongs to the AAA-type superfamily and, like EC 3.6.4.5 (minus-end-directed kinesin ATPase), is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome. Group: Enzymes. Enzyme Commission Number: EC 3.6.4.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4710; proteasome ATPase; EC 3.6.4.8. Cat No: EXWM-4710. | |
| proteasome endopeptidase complex | A 20-S protein composed of 28 subunits arranged in four rings of seven. The outer rings are composed of α subunits, but the β subunits forming the inner rings are responsible for peptidase activity. In eukaryotic organisms there are up to seven different types of β subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. The molecule is barrel-shaped, and the active sites are on the inner surfaces. Terminal apertures restrict access of substrates to the active sites. There is evidence that catalytic subunits are replaced by others under some conditions so as to alter the spec.atalytic proteinase; proteasome organelle; alkaline protease; 26S protease; tricorn proteinase; tricorn protease. Enzyme Commission Number: EC 3.4.25.1. CAS No. 140879-24-9. Alkaline Protease. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4374; proteasome endopeptidase complex; EC 3.4.25.1; 140879-24-9; ingensin; macropain; multicatalytic endopeptidase complex; prosome; multicatalytic proteinase (complex); MCP; proteasome; large multicatalytic protease; multicatalytic proteinase; proteasome organelle; alkaline protease; 26S protease; tricorn proteinase; tricorn protease. Cat No: EXWM-4374. | |
| Protected BiotinLC Serinol Phosphoramidite | Protected BiotinLC Serinol Phosphoramidite, a derivative of biotin and serinol, has been clinically proven to be an exceptional and highly-effective reagent for synthesizing DNA and RNA probes. With its myriad of applications, this reagent is a versatile choice for professionals in the field of tissue imaging and protein interaction studies. A key component in the creation of oligonucleotides, aptamers, and siRNA, Protected BiotinLC Serinol Phosphoramidite deftly performs a plethora of bioanalytical tasks with the utmost precision and accuracy. Alternative Names: 3-Dimethoxytrityloxy-2-(3-((4-t-butylbenzoyl)-biotinyl-3-aminopropyl)-diethyleneglycolyl-propylamido-glycanoylamido)propyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite. Molecular formula: C68H96N7O14PS. Mole weight: 1298.57. | |
| Protected Biotin Serinol Phosphoramidite | Protected Biotin Serinol Phosphoramidite is a biomedicine product used in DNA synthesis for biotin labeling. It serves as a phosphate protecting agent during the synthesis of biotinylated oligonucleotides used in disease diagnostics, gene expression analysis, and biosensor development. Alternative Names: 3-Dimethoxytrityloxy-2-(3-((4-t-butylbenzoyl)-biotinyl)propanamido)propyl-1-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; 3-[Bis(4-methoxyphenyl)phenylmethoxy]-2-[[3-[[5-[(3aS,4S,6aR)-1-[4-(1,1-dimethylethyl)benzoyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxopropyl]amino]propyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[3-[[5-[(3aS,4S,6aR)-1-[4-(1,1-dimethylethyl)benzoyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxopropyl]amino]propyl 2-cyanoethyl ester. CAS No. 1275574-85-0. Molecular formula: C57H75N6O9PS. Mole weight: 1051.28. | |
| Protected cyclic Arg(Pbf)-Gly-Asp(OtBu)-D-Phe-Lys(NH2) | Protected cyclic Arg(Pbf)-Gly-Asp(OtBu)-D-Phe-Lys(NH2). CAS No. 226559-04-2. Molecular formula: C44H65N9O10S. Mole weight: 912.11. | |
| Protected cyclic Arg(Pbf)-Gly-Asp(OtBu)-D-Phe-Lys(NHCbz) | Protected cyclic Arg(Pbf)-Gly-Asp(OtBu)-D-Phe-Lys(NHCbz). Grades: 95%. CAS No. 1186382-58-0. Molecular formula: C52H71N9O12S. Mole weight: 1046.24. | |
| Protected U-U 5'-CEP | Protected U-U 5'-CEP is a naturally-occurring nucleopeptidic replication primer of poliovirus and coxsackie virus. Alternative Names: 5'-O-[[Bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-P-(2-cyanoethyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]uridylyl-(3'→5')-2',3'-diacetate Uridine. CAS No. 915098-72-5. Molecular formula: C40H61N7O17P2Si. Mole weight: 1001.98. | |
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