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PF-1092C is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(3) nM. Synonyms: PF 1092C; PF1092C. Molecular formula: C15H18O4. Mole weight: 262.3.
PF-1163A
PF-1163A is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: (3S,10R,13S)-3-[[4-(2-Hydroxyethoxy)phenyl]methyl]-13-[(2S)-2-hydroxypentyl]-4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione. Grade: ≥95%. CAS No. 258871-59-9. Molecular formula: C27H43NO6. Mole weight: 477.6.
PF-1163B
PF-1163B is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: Antibiotic PF-1163B; (-)-PF 1163B; 3S-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10R-dimethyl-13R-pentyl-1-oxa-4-azacyclotridecane-2,5-dione. Grade: ≥95%. CAS No. 258871-60-2. Molecular formula: C27H43NO5. Mole weight: 461.63.
PF-1355
PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06281355. CAS No. 1435467-38-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100873.
Pf 184
Pf 184. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF 184, NCGC00263213-01, FT-0673646, 1187460-81-6, 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide. Product Category: Heterocyclic Organic Compound. CAS No. 1187460-81-6. Molecular formula: C32H32ClFN6O4. Mole weight: C32H32ClFN6O4. Purity: >98 %. IUPACName: 8-[[2-[(3S,4R)-3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl]-5-chloropyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide. Canonical SMILES: CC1(CN(CC1(C)CO)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl)CO. Product ID: ACM1187460816. Alfa Chemistry ISO 9001:2015 Certified. Categories: PF-184563.
PF184
PF184. CAS No: 1187460-81-6
Sarchem Laboratories New Jersey NJ
PF 184
PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1 β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. Group: Biochemicals. Alternative Names: 8- [ [ [5-Chloro-2- [3, 4-dimethyl-3, 4-bis (hydroxymethyl) -1-pyrrolidinyl] -4-pyridinyl] carbonyl] amino] -1- (4-fluorophenyl) -4, 5-dihydro-1H-benz [g] indazole-3-carboxamide. Grades: Highly Purified. CAS No. 1187460-81-6. Pack Sizes: 10mg. US Biological Life Sciences.
PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. Group: Biochemicals. Alternative Names: (10R)-9, 10, 11, 12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1, 4]diazepino[5', 6':4, 5]thieno[3, 2-f]quinolin-8-one. Grades: Highly Purified. CAS No. 1276121-88-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PF-3644022
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNF? production and has anti-inflammatory effect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1276121-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107427.
PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 ( K d = 2.7 nM; K i =18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-03758309. CAS No. 898044-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13007.
PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23uM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10uM). Group: Biochemicals. Alternative Names: N-3-Pyridinyl-4- [ [3- [ [5- (trifluoromethyl) -2-pyridinyl] oxy] phenyl] methyl] -1-piperidinecarboxamide. Grades: Highly Purified. CAS No. 1196109-52-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PF-3845
PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH) , with a K i of 0.23 μM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196109-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14380.
PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB8761. CAS No. 1341224-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13245.
PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2248666-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13447A.
PF 431396
PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 717906-29-1. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?S. US Biological Life Sciences.
Worldwide
PF-431396
PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 717906-29-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10460.
PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1166393-85-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18312.
PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Group: Biochemicals. Alternative Names: 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; PF 4708671. Grades: Highly Purified. CAS No. 1255517-76-0. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PF-4708671
PF-4708671 is a potent cell-permeable S6K1 inhibitor with a K i of 20 nM and IC 50 of 160 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255517-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15773.
PF 477736
Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Group: Biochemicals. Grades: Highly Purified. CAS No. 952021-60-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences.
Worldwide
PF 477736
PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF 00477736. CAS No. 952021-60-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10032.
PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1? (IC50, 711 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1188296-52-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12470.
PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. Group: Biochemicals. Alternative Names: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride; PF 4800567 Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PF-4942847
PF-4942847. Group: Biochemicals. Alternative Names: 2-Amino-4-[4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide; PF04942847. Grades: Highly Purified. CAS No. 1207961-33-8. Pack Sizes: 5mg. Molecular Formula: C22H23ClF3N7O2, Molecular Weight: 509.91. US Biological Life Sciences.
Worldwide
PF-4 (CXCL4) human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
PF-4 from mouse
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
PF-5006739 is a potent and selective inhibitor of CK1?/? with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1?/? and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1293395-67-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12443.
PF-5081090
PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LpxC-4. CAS No. 1312473-63-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103251.
PF-5081090
PF-5081090 is a pyridone methylsulfone hydroxamate LpxC inhibitor. PF-5081090 is used as an antibiotic in the treatment of serious gram-negative infections. Group: Biochemicals. Alternative Names: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide. Grades: Highly Purified. CAS No. 1312473-63-4. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
PF 514273
PF 514273. Group: Biochemicals. Grades: Purified. CAS No. 851728-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PF-514273
A novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. Group: Biochemicals. Alternative Names: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one. Grades: Highly Purified. CAS No. 851728-60-4. Pack Sizes: 10mg. US Biological Life Sciences.
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II. CAS No. 1415562-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15425.
PF-543 Citrate
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 Citrate induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II Citrate. CAS No. 1415562-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15425A.
PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VS-6062. CAS No. 717907-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10459.
PF-562271
Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Group: Biochemicals. Grades: Highly Purified. CAS No. 717907-75-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C21H20F3N7O3S, Target: FGFR. US Biological Life Sciences.
PF-573228 is a potent and selective FAK inhibitor with IC 50 of 4 nM for purified recombinant catalytic fragment of FAK. Uses: Scientific research. Group: Signaling pathways. CAS No. 869288-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10461.
PF-573228
A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells. Group: Biochemicals. Alternative Names: 3, 4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone; 6- [ (4- ( (3- (Methanesulfonyl) benzyl) amino) -5-trifluoro methyl pyrimidin-2-yl) amino] -3, 4-dihydro-1H-quinolin-2-one; PF 573228. Grades: Highly Purified. CAS No. 869288-64-2. Pack Sizes: 10mg. US Biological Life Sciences.
PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase ( CK1ε and CK1δ ) , with IC 50 s of 7.7 nM and 14 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 950912-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15490.
PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1852452-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117755.
Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system. Group: Biochemicals. Alternative Names: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide; N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide. Grades: Highly Purified. CAS No. 959151-50-9. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PF8380
PF8380. Group: Biochemicals. Alternative Names: 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic Acid 3,5-Dichlorobenzyl Ester; 4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic Acid (3,5-Dichlorophenyl)methyl Ester. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C22H21Cl2N3O5, Molecular Weight: 478.33. US Biological Life Sciences.
Worldwide
PF 8380
PF 8380. Group: Biochemicals. Grades: Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PF-8380
PF-8380 is a potent autotaxin inhibitor with an IC 50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. Uses: Scientific research. Group: Signaling pathways. CAS No. 1144035-53-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13344.