A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
100 ?g/mL in acetonitrile, ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
Retigabine dihydrochloride
Retigabine dihydrochloride. Group: Biochemicals. Alternative Names: N- (2-Amino-4- (4-fluorobenzylamino) phenyl) carbamic acid ethyl ester dihydrochloride; Ethyl [2-amino-4- [ [ (4-fluorophenyl) methyl] amino] phenyl] carbamate dihydrochloride; D 20443. Grades: Highly Purified. CAS No. 150812-13-8. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C16H20Cl2FN3O2. US Biological Life Sciences.
Worldwide
retinal dehydrogenase
A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal. Group: Enzymes. Synonyms: cytosolic retinal dehydrogenase. Enzyme Commission Number: EC 1.2.1.36. CAS No. 37250-99-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1141; retinal dehydrogenase; EC 1.2.1.36; 37250-99-0; cytosolic retinal dehydrogenase. Cat No: EXWM-1141.
Retinal dehydrogenase 1 (88-96)
Retinal dehydrogenase 1 (88-96) is a 9-aa peptide. Retinal dehydrogenase 1 can convert/oxidize retinaldehyde to retinoic acid. Synonyms: RALDH 1 (88-96); Aldehyde dehydrogenase family 1 member A1 (88-96).
Retinal Microvascular Endothelial Cells, Human (Frozen)
Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences.
Worldwide
Retinal Microvascular Endothelial Cells, Human (T-25 flask)
Passage 3 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >16 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences.
Worldwide
Retinamide,N-ethyl-
Retinamide,N-ethyl-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: all-trans-N-Ethylretinamide; Ro 8-4968; Vitamin-A-saeureethylamid; Retinoic acid ethyl amide; Retinamide,N-ethyl-,all-trans; Retinamide,N-ethyl; Ethyl retinamide; Vitamin A acid ethylamide. Product Category: Heterocyclic Organic Compound. CAS No. 33631-41-3. Molecular formula: C22H33NO. Mole weight: 327.56. Purity: 0.96. IUPACName: (2E,4E,6E,8E)-N-ethyl-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide. Canonical SMILES: CCNC(=O)C=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C. Density: 0.959g/cm³. Product ID: ACM33631413. Alfa Chemistry ISO 9001:2015 Certified.
Retinoblastoma protein human
recombinant, expressed in insect cells, ?70% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
Retinoblastoma, Recombinant Fusion Protein, aa701-928, Phosphorylated (Rb). Group: Molecular Biology. Pack Sizes: 100ul. US Biological Life Sciences.
Worldwide
Retinoic acid
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC 50 s of 14 nM for RARα/β/&gamma. Retinoic acid bind to PPARβ/δ with K d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Uses: Scientific research. Group: Natural products. Alternative Names: Vitamin A acid; all-trans-Retinoic acid; ATRA. CAS No. 302-79-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-14649.
Retinoic Acid-Gambogic Acid Liposome
Retinoic acid is an intermediate product of vitamin A metabolism. Gambogic acid is derived from the gamboge and is a protease activator and apoptosis inducer. This product is a pre-formulated composite liposome with retinoic acid and gambogic acid. It can induce apoptosis in tumor cells and exerts synergistic anti-tumor effects. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes.
Retinoic Acid-Glycyrrhizic Flavone Liposome
Retinoic acid is an intermediate product of vitamin A metabolism. Glycyrrhizic flavone are compounds extracted from licorice that have corticosteroid-like effects. This product is a pre-formulated composite liposome with retinoic acid and glycyrrhizic flavone. It can be used for epithelial cell abnormalities such as hyperpigmentation and photoaging. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes.
Retinoic acid (GMP)
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors[1][2][3][4][5][6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Vitamin A acid (GMP); all-trans-Retinoic acid (GMP); ATRA (GMP). CAS No. 302-79-4. Pack Sizes: 10 mg; 50 mg. Product ID: HY-14649G.
Retinoic Acid Liposome
Retinoic acid is an intermediate product of vitamin A metabolism, which can affect bone growth and promote metabolic effects such as epithelial cell proliferation, differentiation and keratolysis. This product is a pre-formulated liposome with vitamina acid. It is only for research purposes. Group: Drug-loaded liposome. Categories: liposomes, niosomes, ethosomes, and transfersomes.
Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RAR?/?/?. Retinoic acid bind to PPAR?/? with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha. Uses: Scientific research. Group: Natural products. Alternative Names: Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard). CAS No. 302-79-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-14649R.
retinoid isomerohydrolase
This enzyme, which operates in the retinal pigment epithelium (RPE), catalyses the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol, a key step in the regeneration of the visual chromophore in the vertebrate visual cycle. Interaction of the enzyme with the membrane is critical for its enzymic activity. Group: Enzymes. Synonyms: all-trans-retinyl-palmitate hydrolase (ambiguous); retinol isomerase (ambiguous); all-trans-retinol isomerase:hydrolase (ambiguous); all-trans-retinylester 11-cis isomerohydrolase; RPE65 (gene name). Enzyme Commission Number: EC 3.1.1.64. CAS No. 106389-24-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3492; retinoid isomerohydrolase; EC 3.1.1.64; 106389-24-6; all-trans-retinyl-palmitate hydrolase (ambiguous); retinol isomerase (ambiguous); all-trans-retinol isomerase:hydrolase (ambiguous); all-trans-retinylester 11-cis isomerohydrolase; RPE65 (gene name). Cat No: EXWM-3492.
Retinol
Retinol is found in vitamin A, and is instrumental for stimulating new skin cells, which eventually contribute to younger looking skin. Pack Sizes: 1 kg. Product ID: CDC10-0559. Category: Anti-Acne Ingredients. Product Keywords: Cosmetic Ingredients; Active Ingredients; Anti-Acne Ingredients; Retinol; CDC10-0559.
Retinol
Fluorescence/Luminescence Spectroscopy. Uses: For analytical and research use. Group: Reagents. CAS No. 68-26-8. Pack Sizes: 250MG, 1G.
Retinol impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1331640-07-3. Molecular formula: C20H28O3. Mole weight: 316.44. Catalog: APB1331640073.
retinol O-fatty-acyltransferase
Acts on palmitoyl-CoA and other long-chain fatty-acyl derivatives of CoA. Group: Enzymes. Synonyms: retinol acyltransferase; retinol fatty-acyltransferase. Enzyme Commission Number: EC 2.3.1.76. CAS No. 81295-48-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2256; retinol O-fatty-acyltransferase; EC 2.3.1.76; 81295-48-9; retinol acyltransferase; retinol fatty-acyltransferase. Cat No: EXWM-2256.
Retinol palmitate
It can transdermally absorb, resist keratinization, stimulate the growth of collagen and elastin, and increase the thickness of epidermis and dermis. Enhances skin elasticity, effectively eliminates wrinkles, promotes skin renewal, maintains skin vitality. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Vitamin A palmitate, all-trans-Retinol palmitate. Product Category: Material of cosmetics. CAS No. 79-81-2. Molecular formula: C36H60O2. Mole weight: 524.86. Product ID: ACM79812. Alfa Chemistry ISO 9001:2015 Certified. Categories: Retinyl palmitate.
Retinol solution
100 ?g/mL ± 25% (Refer to COA) (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, reference material. Group: Certified reference materials (crms).
Retinyl acetate
Retinyl acetate is a synthetic acetate ester form derived from retinol and has potential antineoplastic and chemo preventive activities [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Retinol acetate; Vitamin A acetate. CAS No. 127-47-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-N0679.
Retinyl Acetate-Water Soluble
BioReagent, suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
Retinyl heptanoate
Retinyl heptanoate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Retinyl heptanoate, EINECS 289-433-6, 88641-44-5. Product Category: Heterocyclic Organic Compound. CAS No. 88641-44-5. Molecular formula: C27H42O2. Mole weight: 398.621180 [g/mol]. Purity: 0.96. IUPACName: [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] heptanoate. Canonical SMILES: CCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(CCCC1(C)C)C. Density: 0.985g/cm³. ECNumber: 289-433-6. Product ID: ACM88641445. Alfa Chemistry ISO 9001:2015 Certified.
Retinyl palmitate
Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations. Uses: Scientific research. Group: Natural products. Alternative Names: Vitamin A palmitate; Retinol palmitate. CAS No. 79-81-2. Pack Sizes: 100 mg. Product ID: HY-B1384.
Retinyl palmitate solution
100 ?g/mL (Ethanol with 0.1% (w/v) BHT), ampule of 1 mL, certified reference material. Group: Certified reference materials (crms).
Retinyl Retinoate
Retinyl Retinoate. Group: Biochemicals. Alternative Names: Retinoic Acid Retin-15-yl Ester; Retinoic Acid Ester with Retinol. Grades: Highly Purified. CAS No. 15498-86-9. Pack Sizes: 10mg, 25mg. US Biological Life Sciences.
Worldwide
R-(+)-Etomoxir
R-(+)-Etomoxir. Group: Biochemicals. Alternative Names: (R) -2- [6- (4-Chlorophenoxy) hexyl] oxiranecarboxylic acid, ethyl ester. Grades: Highly Purified. CAS No. 124083-20-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H23ClO4. US Biological Life Sciences.
Worldwide
r-(+)-Etomoxir carboxylate,potassium salt
r-(+)-Etomoxir carboxylate,potassium salt. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (R)-2-[6-(4-Chlorophenoxy)hexyl]oxiranecarboxylic Acid Potassium Salt; (2R)-2-[6-(4-Chlorophenoxy)hexyl]oxiranecarboxylic Acid Potassium Salt. Product Category: Heterocyclic Organic Compound. Appearance: White Solid. CAS No. 132308-39-5. Molecular formula: C15H8ClKO4. Mole weight: 336.85. Purity: 0.96. IUPACName: potassium;(2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate. Canonical SMILES: C1C(O1)(CCCCCCOC2=CC=C(C=C2)Cl)C(=O)[O-].[K+]. Product ID: ACM132308395. Alfa Chemistry ISO 9001:2015 Certified.
An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug. Group: Biochemicals. Alternative Names: (R) -2- [6- (4-Chlorophenoxy) hexyl] oxiranecarboxylic Acid, Ethyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Retorphan
Retorphan. Group: Biochemicals. Alternative Names: N-[(2R)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine Phenylmethyl Ester; Dexecadotril. Grades: Highly Purified. CAS No. 112573-72-5. Pack Sizes: 5mg. Molecular Formula: C21H23NO4S, Molecular Weight: 385.48. US Biological Life Sciences.
Worldwide
Retorphan-d5
Retorphan-d5. Group: Biochemicals. Alternative Names: N-[(2R)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine Phenylmethyl Ester-d5; Dexecadotril-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C21H18NO4S, Molecular Weight: 385.48. US Biological Life Sciences.
Worldwide
Retosiban
Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a K i of 0.65 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK 221149; GSK 221149A. CAS No. 820957-38-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14778.
RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1036069-26-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108636.
RETRA hydrochloride
RETRA hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1173023-52-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC 50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1201652-50-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122571.
Retro-2
A cell-permeable tricyclic imine compound that inhibits the endosome-to-Golgi retrograde transport, but not cellular uptake, of CtxB, StxB without affecting cellular uptake/trafficking of Tf or EGF. Group: Fluorescence/luminescence spectroscopy.
Retrochalcone
Retrochalcone. Group: Biochemicals. CAS No. 34221-41-5. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Retrocyclin-1
Retrocyclin-1, a theta-defensin, is a circular octadecapeptide containing an internal trisulfide ladder. In addition to its antimicrobial activity, it has a significant in vitro ability to protect human cells from infection with the T- and M-tropic strains of HIV-1. Retrocyclin is a small molecule HIV-1 entry inhibitor. Synonyms: RC-100; Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg) (Disulfide bridge: Cys3-Cys16, Cys5-Cys14, Cys7-Cys12); cyclo[L-arginyl-L-cysteinyl-L-isoleucyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-isoleucyl-L-cysteinyl-L-arginyl-L-cysteinyl-L-isoleucyl-L-cysteinyl-glycyl-L-arginyl-glycyl-L-isoleucyl-L-cysteinyl] (2->11),(4->9),(13->18)-tris(disulfide). Grade: ≥95%. CAS No. 724760-19-4. Molecular formula: C74H128N30O18S6. Mole weight: 1918.39.
Retrocyclin-2
Retrocyclin-2 is a synthetic antimicrobial peptide. It has activity against viruses. Synonyms: 1-[3-[tetrakis(3-guanidinopropyl)-tetrakis[(1S)-1-methylpropyl]-octadecaoxo-[?]yl]propyl]guanidine. Molecular formula: C78H137N33O18S6. Mole weight: 2017.5.
Retrocyclin-3
Retrocyclin-3 is a synthetic antimicrobial peptide. It has activity against viruses. Synonyms: 1-[3-[pentakis(3-guanidinopropyl)-tetrakis[(1S)-1-methylpropyl]-octadecaoxo-[?]yl]propyl]guanidine. Molecular formula: C82H146N36O18S6. Mole weight: 2116.7.
retro-Methyl-α-ionol
An intermediate for synthesizing β-Damascenone. Group: Biochemicals. Alternative Names: (6Z). Grades: Highly Purified. CAS No. 945426-65-3. Pack Sizes: 50mg. US Biological Life Sciences.
Comments: Retroviral reverse transcriptase is a multifunctional enzyme responsible for viral replication. To perform this task the enzyme combines two distinct activities. The polymerase domain (EC 2.7.7.49, RNA-directed DNA polymerase) occupies the N-terminal two-thirds of the reverse transcriptase whereas the ribonuclease H domain comprises the C-terminal remaining one-third. The RNase H domain of Moloney murine leukemia virus and Human immunodeficiency virus display two metal binding sites. Group: Enzymes. Synonyms: RT/RNase H; retroviral reverse transcriptase RNaseH; HIV RNase H. Enzyme Commission Number: EC 3.1.26.13. CAS No. 9050-76-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3589; retroviral ribonuclease H; EC 3.1.26.13; 9050-76-4; RT/RNase H; retroviral reverse transcriptase RNaseH; HIV RNase H. Cat No: EXWM-3589.
It is originally isolated from Act. sp. Reumycin is toxic to Airy carcinoma, sarcoma-180, sarcoma-37, lymphosarcoma and other tumor cells. Synonyms: Reumitsin; Rheumygin; 1-demethyltoxoflavin; NSC 99733; 6-Methylpyrimido(5,4-e)-as-triazine-5,7(1H,6H)-dione. CAS No. 5016-18-2. Molecular formula: C6H5N5O2. Mole weight: 179.14.
Reutericyclin
Reutericyclin (Reutericycline), a unique tetramic acid, is an antibiotic produced by some strains of Lactobacillus reuteri. Reutericyclin (Reutericycline) exhibits a broad inhibitory spectrum including Lactobacillus spp. , Bacillus subtilis , B. cereus , Enterococcus faecalis , Staphylococcus aureus , and Listeria innocua [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Reutericycline. CAS No. 303957-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103249.
Reuterin
Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates[1][2]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Hydroxypropionaldehyde; 3-Hydroxypropanal. CAS No. 2134-29-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N8461.
Revaprazan hydrochloride
Revaprazan hydrochloride. Group: Biochemicals. Alternative Names: 4-(3,4-Dihydro-1-methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-dimethyl-2-pyrimidinamine hydrochloride; 5,6-Dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride; Revaprazan hydrochloride. Grades: Highly Purified. CAS No. 178307-42-1. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C22H24ClFN4. US Biological Life Sciences.
Worldwide
Revaprazan hydrochloride
Revaprazan hydrochloride is a novel acid pump antagonist ( APA ). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 178307-42-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7067.
Revefenacin
Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a K i of 0.18 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TD-4208; GSK1160724. CAS No. 864750-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15851.
REV-ERB? Agonist, GSK4112
The REV-ERB? Agonist, GSK4112 controls the biological activity of REV-ERB?. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy.
REV-ERB Agonist II, SR9009
A pyrrolidinecarbamate compound that acts as a specific REV-ERB-alpha/beta agonist. Exhibits a direct and reversible binding (Kd = 800nM REV-ERB-alpha) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800nM in Gal4-REV-ERB-alpha and beta transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern. 217739, CAS # 1379686-30-2, acts as a specific REV-ERB-α/ β agonist that exhibits a direct and reversible binding (Kd = 800nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1379686-30-2. Pack Sizes: 25mg. Molecular Formula: C??H??ClN?O?S. US Biological Life Sciences.
Worldwide
Reveromycin A
Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of epidermal growth factor (EGF). It is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behavior against human cell lines KB and K562 as well as potent antifungal activity. More recently it has been shown to inducing apoptosis in osteoclasts thus inhibiting bone resorption. Group: Biochemicals. Grades: Highly Purified. CAS No. 134615-37-5. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
Reveromycin A
The dominant analogue of complex of spiroketals isolated from streptomyces sp. It is an inhibitor of the mitogenic activity of EGF and a G1 phase cell cycle inhibitor. It selectively inhibits isoleucyl-trna synthetase. It has anti-proliferation effect on human cell lines KB and K562, and has potent antifungal activity. Synonyms: (-)-Reveromycin A; [2S-[2α(1E,3E),3β,6α[8S*(2E,4E,6R*,7R*,8E),9R*]]]-butanedioic acid mono[3-butyl-8-(9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrienyl)-2-(4-carboxy-3-methyl-1,3-butadienyl)-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] Ester; Butanedioic Acid Mono[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrienyl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadienyl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] Ester. Grade: >99% by HPLC. CAS No. 134615-37-5. Molecular formula: C36H52O11. Mole weight: 660.79.
Reveromycin A
Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces , is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 134615-37-5. Pack Sizes: 1 mg. Product ID: HY-129337.
Reveromycin A. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2E,6E,8E)-10-[3-butyl-2-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-1,7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid. Appearance: Lyophilized. CAS No. 134615-37-5. Molecular formula: C36H52O11. Mole weight: 660.8. Purity: 0.99. Canonical SMILES: CCCCC1(CCC2(CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)OC1C=CC(=CC(=O)O)C)OC(=O)CCC(=O)O. Product ID: ACM134615375. Alfa Chemistry ISO 9001:2015 Certified.
Reveromycin B
Reveromycin B is a polyketide antibiotic isolated from Streptomyces, which can inhibit mitotic activity. Synonyms: BDBM50217842; ZINC49871994. Grade: >98% by HPLC. CAS No. 144860-68-4. Molecular formula: C36H52O11. Mole weight: 660.79.
Reveromycin B
Reveromycin B is an much less active analogue of reveromycin A formed by rearrangement of the 6to6 spiroketal to a 5to6 spiroketal. Lacking much of the biological activity of reveromycin A, the reveromycin B is a useful negative control in resolving the mode of action of this class. Group: Biochemicals. Grades: Highly Purified. CAS No. 144860-68-4. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
Reveromycin C
Reveromycin C is a minor analogue of the reveromycin complex isolated from a Streptomyces sp. Published information suggests that reveromycin C exhibits comparable potency to reveromycin A, its butyl homologue. In Microbial Screening Technologies in-house screens Reveromycins C and A had similar biological profiles but Reveromycin C was generally more potent. Group: Biochemicals. Grades: Highly Purified. CAS No. 144860-69-5. Pack Sizes: 250ug. US Biological Life Sciences.
Worldwide
Reveromycin C
Reveromycin C. Uses: Designed for use in research and industrial production. Additional or Alternative Names: REVEROMYCIN C. Product Category: Heterocyclic Organic Compound. Appearance: White to tan solid. CAS No. 144860-69-5. Molecular formula: C37H54O11. Mole weight: 674.8. Purity: 0.95. Canonical SMILES: CC(C)CCC1(CCC2(CCC(C)C(C/C=C(\\C)/C=C/C(O)C(C)/C=C/C(=O)O)O2)OC1/C=C/C(=C/C( =O)O)/C)OC(=O)CCC(=O)O. Product ID: ACM144860695. Alfa Chemistry ISO 9001:2015 Certified.