A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 872573-93-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12529.
Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M. Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards. Group: Biochemicals. Alternative Names: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?OS?. US Biological Life Sciences.
Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Group: Biochemicals. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Worldwide
Ro 363 hydrochloride
Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 250580-70-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123268A.
Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RAR?) antagonist. Ro 41-5253 can bind RAR? without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 144092-31-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116248.
Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC 50 of appr 6.5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 189197-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18630A.
Ro 48-8071 fumarate
Ro 48-8071 fumarate. Group: Biochemicals. Grades: Purified. CAS No. 189197-69-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
RO4929097
RO4929097 (RG-4733) is an orally active ? secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of A?40 and Notch with EC50 of 14 nM and 5 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG-4733. CAS No. 847925-91-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11102.
Ro 51
Ro 51 is a potent and selective dual antagonist of purinoceptor subtypes P2X3 and P2X2/3. P2X3 and P2X2/3 have been shown to play a pivotal role in models of various pain conditions making Ro 51 a potential option in the treatment of pain. Group: Biochemicals. Alternative Names: 2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2-pyrimidinyl]amino]-1,3-propanediol; RO-51. Grades: Highly Purified. CAS No. 1050670-85-3. Pack Sizes: 10mg. US Biological Life Sciences.
Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBF? interaction inhibitor that represses RUNX1/CBFB-dependent transactivation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 30195-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108470.
RO5454948
Mirk-IN-1 (Dyrk1B/A-IN-1) is a highly efficient and selective inhibitor of Dyrk1B and Dyrk1A, with IC50 values of 68 and 22nM respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mirk-IN-1; Dyrk1B/A-IN-1. CAS No. 1386979-55-0. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-12838.
RO5 Drug-like Natural Product Library
2743 is a collection of natural products that meet the "Lipinski's Rule of Five" and have high potential for drug discovery. - Most of the NPs have clear biological activities, with various functions including anti-tumor, anti-inflammatory, antioxidant, neuroprotection and more. - Structural diversity, containing flavonoids, saponins, terpenoids, alkaloids and other categories. - Various detection techniques such as NMR, HPLC/LCMS to ensure accurate structure and high purity of the products and reduce false positives. Uses: Scientific use. Product Category: L6160. Categories: RO5 Drug-like Natural Product Libraries.
Ro60-0175
Ro60-0175 is a potent and selective agonist of 5-HT 2C receptor. Ro60-0175 reduces self-administration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169675-08-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123838.
Ro 60-0175 fumarate
Ro 60-0175 fumarate. Group: Biochemicals. Grades: Purified. CAS No. 169675-09-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Ro60-0175 fumarate
Ro60-0175 fumarate is a potent and selective agonist of 5-HT 2C receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169675-09-6. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-103140.
Ro 61-8048
Ro 61-8048. Group: Biochemicals. Grades: Purified. CAS No. 199666-03-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Ro 61-8048
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 199666-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12347.
Ro 64-5229. Group: Biochemicals. Grades: Purified. CAS No. 246852-46-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Ro 64-6198
Ro 64-6198 is a potent, selective, nonpeptide, high-affinity, high cellular permeability and brain penetration N/OFQ receptor (NOP) agonist with an EC 50 value of 25.6 nM. Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors. Ro 64-6198 can be used for stress and anxiety, addiction, neuropathic pain, cough, and anorexia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 280783-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-12844.
Ro 67-4853. Group: Biochemicals. Grades: Purified. CAS No. 302841-89-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Ro 67-7476
Ro 67-7476 is a potent positive allosteric modulator of mGluR 1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC 50 of 60.1 nM [1] [2]. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate ( EC 50 =163.3 nM) [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 298690-60-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100403.
Ro 67-7476
Ro 67-7476. Group: Biochemicals. Grades: Purified. CAS No. 298690-60-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
RO6806051
RO6806051 (compound12) is a potent dual fatty acid binding protein 4 and 5 (FABP4 and FABP5) inhibitor with good selectivity and absorption, distribution, metabolism and excretion (eADME) properties[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1433901-75-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161702.
RO6889678
RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 μl/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 μl/min per mg protein, respectively. The induction potential of RO6889678 on cytochrome P450 (P450) enzymes and transporters at steady state was assessed and cotreatment with ritonavir revealed a complex drug-drug interaction with concurrent P450 inhibition and moderate UDP-glucuronosyltransferase induction. Uses: Designed for use in research and industrial production. Additional or Alternative Names: RO6889678; RO-6889678; RO 6889678. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1578153-27-1. Molecular formula: C21H20ClFN4O5S. Mole weight: 494.92. Purity: >98%. IUPACName: (S)-4-(((R)-6-(2-Chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid. Canonical SMILES: O=C([C@H]1N(CC2=C(C(OC)=O)[C@H](C3=CC=C(F)C=C3Cl)N=C(C4=NC=CS4)N2)CCOC1)O. Product ID: ACM1578153271. Alfa Chemistry ISO 9001:2015 Certified.
Ro 8-4304 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1312991-77-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Ro 90-7501
Ro 90-7501. Group: Biochemicals. Grades: Purified. CAS No. 293762-45-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ROAD-1
Oral Mucosal Alpha-Defensin is an antimicrobial peptide found in Macaca mulatta (Rhesus monkey), and has antibacterial and antifungal activity. Synonyms: Rhesus macaque oral alpha-defensin-1; Oral Mucosal Alpha-Defensin. Grade: >98%. Molecular formula: C145H245N61O44S6. Mole weight: 3739.35.
Robatumumab (Sch 717454) is an anti-human IGF-1R ( insulin-like growth factor receptor-1 ) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Sch 717454; 19D12. CAS No. 934235-44-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99218.
Robenacoxib
Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective COX-2 inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220991-32-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-118078.
Robenacoxib.
A novel COX-2 selective inhibitor, as a. Group: Biochemicals. Alternative Names: 5-Ethyl-2-[ (2, 3, 5, 6-tetrafluorophenyl) amino]benzeneacetic Acid. Grades: Highly Purified. CAS No. 220991-32-2. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Robenacoxib-[d5]
Robenacoxib-[d5] is the labelled analogue of Robenacoxib. Robenacoxib is a nonsteroidal anti-inflammatory drug used in veterinary medicine. Synonyms: Robenacoxib-d5; 2-(5-(Ethyl-d5)-2-((2,3,5,6-tetrafluorophenyl)amino)phenyl)acetic acid. Grade: 95% by HPLC; 98% atom D. CAS No. 2012598-81-9. Molecular formula: C16H8D5F4NO2. Mole weight: 332.31.
Robenidine-d8 hydrochloride
analytical standard. Group: Application areas.
Robenidine-[d8] Hydrochloride
Robenidine-[d8] Hydrochloride is a labelled salt of Robenidine. Robenidine is an antibiotic used for control of coccidiosis and protozoa. Synonyms: Robenidine D8 Hydrochloride. Grade: 95% by HPLC; 98% atom D. CAS No. 1173097-77-2. Molecular formula: C15H6D8Cl3N5. Mole weight: 378.71.
Robenidine hydrochloride
Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC 50 s of 8.1 and 4.7 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 25875-50-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B2157.
Robinetin. Group: Biochemicals. Alternative Names: 3,3',4',5',7-Pentahydroxyflavone. Grades: Highly Purified. CAS No. 490-31-3. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C15H10O7. US Biological Life Sciences.
Worldwide
Robinin
Robinin is a flavonoid glycoside isolated from the barks of Rauvolfia yunnanensis Tsiang. Robinin exhibits protective effect against the ox-LDL induced inflammation stress in hPBMCs by inhibiting TLR4-NF-κB signaling pathway. Synonyms: Kaempferol-3-O-gal-rham-7-O-rham; Kaempferol-3-O-robinoside-7-O-rhamnoside; 4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]oxy]-7-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-; 3-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-galactopyranosyl]oxy]-7-[(6-deoxy-α-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Kaempferol 3-O-α-L-rhamnopyranosyl-(1→6)-β-D-galactopyranosyl 7-O-α-L-rhamnopyranoside; Kaempferol 3-robinoside-7-rhamnoside. Grade: >98%. CAS No. 301-19-9. Molecular formula: C33H40O19. Mole weight: 740.66.
Robinin
Robinin. Group: Biochemicals. CAS No. 301-19-9. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Roblitinib
Roblitinib (FGF-401) is an orally active and highly selective FGFR4 inhibitor with an IC 50 of 1.9 nM [1]. Roblitinib has antitumor activity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FGF-401. CAS No. 1708971-55-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101568.
Robotnikinin (N-2-acetamide)
Sonic hedgehog (Shh) signaling small molecule modulator. Inhibits the Shh pathway in human cell lines upstream of Smo. Targets the Shh N-terminal protein. Group: Biochemicals. Alternative Names: N--2-acetamide. Grades: Highly Purified. CAS No. 1132653-79-2. Pack Sizes: 1mg. Molecular Formula: C25H27ClN2O4. US Biological Life Sciences.
Worldwide
Roburic Acid
Roburic Acid. Group: Biochemicals. Grades: Plant Grade. CAS No. 6812-81-3. Pack Sizes: 20mg. Molecular Formula: C30H48O2, Molecular Weight: 440.7. US Biological Life Sciences.
ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1859141-26-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103706.
Rocaglamide
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-?B activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: Roc-A. CAS No. 84573-16-0. Pack Sizes: 10 mM * 1 mL; 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19356.
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (1R)-2,3,3a,8b-Tetrahydro-1α,8bβ-dihydroxy-6,8-dimethoxy-3aβ-(4-methoxyphenyl)-N,N-dimethyl-3β-phenyl-1H-cyclopenta[b]benzofuran-2α-carboxamide. Product Category: Inhibitors. CAS No. 84573-16-0. Molecular formula: C29H31NO7. Mole weight: 505.6. Purity: 95%+. Product ID: ACM84573160. Alfa Chemistry ISO 9001:2015 Certified.
ROCAGLAMIDE
Rocaglamide is the first cyclopenta[b]benzofuran derivative extracted from Aglaia elliptifolia in 1982 by King and colleagues. Its IC50 value is ~50 nM for the heat shock reporter. It has antileukemic activity and displays potent insecticidal, antifungal, anti-inflammatory and anticancer activities. It is an immunosuppressant that inhibits activation of NF-kB and NF-AT. It markedly inhibited tumor growth from Huh-7 cells propagated in severe combined immunodeficient mice. It induces apoptosis in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells. It inhibit protein synthesis without affecting DNA or RNA synthesis. Uses: Rocaglamide has antileukemic activity and displays potent insecticidal, antifungal, anti-inflammatory and anticancer activities. it is an immunosuppressant that inhibits activation of nf-kb and nf-at. it inhibit protein synthesis without affecting dna or rna synthesis. Synonyms: Rocaglamide; Rocaglamide A; RocA; NSC 326408. (1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide; NSC 326408; Roc-A; Rocaglamide A; 1H-Cyclopenta(b)benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-; [1R-(1α. Grade: 95%. CAS No. 84573-16-0. Molecular formula: C29H3
Rocatinlimab
Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated, immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 451; KHK4083. CAS No. 2431972-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99955.
Rochelle salt is an organic-inorganic compound commonly used as a catalyst and complexing reagent. It can be used to catalyze or promote certain chemical reactions, and is widely used in batteries, pharmaceuticals and food industries. In addition, this compound is also used as a substrate or intermediate in some biochemical reactions. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: L-Tartaric acid potassium sodium salt tetrahydrate; Potassium sodium tartrate tetrahydrate; Sodium potassium tartrate tetrahydrate. CAS No. 6381-59-5. Pack Sizes: 25 g; 100 g. Product ID: HY-Y1332.
Rociletinib
Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686; AVL-301; CNX-419. CAS No. 1374640-70-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729.
Rociletinib hydrobromide
Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686 hydrobromide; AVL-301 hydrobromide; CNX-419 hydrobromide. CAS No. 1446700-26-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729A.
ROCK2-IN-6 hydrochloride (Comp A) is a selective ROCK2 inhibitor, can be used for ROCK mediated diseases, autoimmune diseases and inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2762238-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156592A.