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| Product | Description | |
|---|---|---|
| Saxagliptin Impurity 66 | Saxagliptin Impurity 66. Uses: For analytical and research use. Group: Impurity standards. CAS No. 361440-68-8. Molecular Formula: C6H10N2O. Mole Weight: 126.16. Catalog: APB361440688. |  |
| Saxagliptin Impurity 67 | Saxagliptin Impurity 67. Uses: For analytical and research use. Group: Impurity standards. CAS No. 709031-39-0. Molecular Formula: C6H11ClN2O. Mole Weight: 162.62. Catalog: APB709031390. | |
| Saxagliptin Impurity 68 | Saxagliptin Impurity 68. Uses: For analytical and research use. Group: Impurity standards. CAS No. 709031-43-6. Molecular Formula: C23H33N3O4. Mole Weight: 415.53. Catalog: APB709031436. | |
| Saxagliptin Impurity 69 | Saxagliptin Impurity 69. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H26N2O4. Mole Weight: 334.42. Catalog: APB09784. | |
| Saxagliptin Impurity 7 | An impurity of saxagliptin.Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. Synonyms: (1aS,4S,6aR,7aS)-Hexahydro-4-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)-1H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazine-3,6-dione. Grades: > 95%. CAS No. 1350800-77-9. Molecular formula: C18H24N2O3. Mole weight: 316.4. |  |
| Saxagliptin Impurity 7 | Saxagliptin Impurity 7. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H25N3O3. Mole Weight: 331.42. Catalog: APB09768. | |
| Saxagliptin Impurity 70 | Saxagliptin Impurity 70. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H27N3O3. Mole Weight: 333.43. Catalog: APB09785. | |
| Saxagliptin Impurity 71 | Saxagliptin Impurity 71. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H24N2O3. Mole Weight: 316.4. Catalog: APB09786. | |
| Saxagliptin Impurity 72 | Saxagliptin Impurity 72. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H25N3O2. Mole Weight: 315.42. Catalog: APB09787. | |
| Saxagliptin Impurity 73 | Saxagliptin Impurity 73. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C18H26ClN3O2. Mole Weight: 351.88. Catalog: APB09789. | |
| Saxagliptin Impurity 8 | Saxagliptin Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 841302-24-7. Molecular Formula: C18H25N3O3. Mole Weight: 331.42. Catalog: APB841302247. | |
| Saxagliptin Impurity 8 (N-Formyl Saxagliptin) | An impurity of saxagliptin.Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. Grades: > 95%. Molecular formula: C19H25N3O3. Mole weight: 343.43. | |
| Saxagliptin Impurity 9 | An impurity of saxagliptin.Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. Grades: > 95%. Molecular formula: C11H18N2O3. Mole weight: 226.28. | |
| Saxagliptin Impurity 9 | Saxagliptin Impurity 9. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C1713CH24D2ClN3O2. Mole Weight: 354.88. Catalog: APB09769. | |
| Saxagliptin intermediate b | Heterocyclic Organic Compound. CAS No. 1110783-95-3. Purity: 0.96. Catalog: ACM1110783953. |  |
| Saxagliptin Keto Impurity | An impurity of Saxagliptin. Saxagliptin is an inhibitor of dipeptidyl peptidase-4 (DPP-4) used as a hypoglycemic drug. It was approved to treat type 2 diabetes. Synonyms: (1S,3S,5S)-2-((R)-2-amino-2-((1s,3R,5S,7S)-4-oxoadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Grades: 95%. Molecular formula: C18H23N3O2. Mole weight: 313.4. | |
| Saxagliptin monohydrate | Saxagliptin hydrate is a selective and reversible DPP4 inhibitor. It demonstrates greater specificity for DPP4 than for either the DPP8 or DPP9 enzymes. It reduces the degradation of the incretin hormone glucagon-like peptide-1, thereby enhancing its actions, and is associated with improved β-cell function and suppression of glucagon secretion. Synonyms: BMS-477118 hydrate; BMS 477118 hydrate; BMS477118 hydrate; Onglyza hydrate. Grades: >98%. CAS No. 945667-22-1. Molecular formula: C18H27N3O3. Mole weight: 333.43. | |
| Saxagliptin O- β-D-glucuronide | Saxagliptin O- β-D-glucuronide. Group: Biochemicals. Alternative Names: (2S,3S,5R,6S)-6-(((1R,3S,5R,7S)-3-((S)-1-Amino-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid. Grades: Highly Purified. CAS No. 1155849-58-3. Pack Sizes: 500ug. Molecular Formula: C24H33N3O8, Molecular Weight: 491.53. US Biological Life Sciences. |  Worldwide |
| Saxagliptin O-Sulfate | Saxagliptin O-Sulfate. Group: Biochemicals. Alternative Names: (1S, 3S, 5S)-2-[(2S)-2-Amino-2-[3-(sulfooxy)tricyclo[3. 3. 1. 13, 7]dec-1-yl]acetyl]-2-Azabicyclo[3. 1. 0]hexane-3-carbonitrile. Grades: Highly Purified. CAS No. 1429782-94-4. Pack Sizes: 500ug. Molecular Formula: C18H25N3O5S, Molecular Weight: 395.47. US Biological Life Sciences. | Worldwide |
| Sazetidine A Dihydrochloride | Sazetidine A Hydrochloride is an α4 β2 nicotinic receptor desensitizing agent that exhibits analgesic properties. Sazetidine A Hydrochloride may be used to develop treatments and therapies that aid smoking cessation. Group: Biochemicals. Alternative Names: 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol dihydrochloride. Grades: Highly Purified. CAS No. 1197329-42-2. Pack Sizes: 5mg, 10mg. Molecular Formula: C??H??ClN?O?, Molecular Weight: 333.25. US Biological Life Sciences. | Worldwide |
| Sazetidine A hydrochloride | Sazetidine A hydrochloride is an α4β2 nicotinic acetylcholine receptor ligand (Ki = 0.26 and 54 nM at α4β2 and α3β4 receptors, respectively), displaying analgesic activity in vivo. Sazetidine A hydrochloride may act as a silent desensitizer or an agonist. Synonyms: 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol hydrochloride. Grades: ≥98% by HPLC. CAS No. 1197329-42-2. Molecular formula: C15H20N2O2.HCl. Mole weight: 296.797. | |
| SB1317 | SB1317 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor. It dose-dependently inhibits signaling pathways downstream of CDKs, JAK2 and FLT3 in cancer cells with the main targets being CDKs. SB1317 is anti-proliferative in a broad range of tumor cell lines, inducing G1 cell cycle arrest and apoptosis. In vivo, SB1317 exhibits favorable pharmacokinetics after oral dosing in xenograft models and accumulates in tumor tissues, inducing an effective blockade of both CDK and STAT signaling. SB1317 induces tumor regression after oral dosing on both daily and intermittent schedules in a murine model of mutant-FLT3 leukemia (MV4-11) and prolongs survival in a disseminated AML model with wild-type FLT3 and JAK2 (HL-60). SB1317 is active in various models of leukemia and provide a rationale for the ongoing clinical evaluation of TG02 in patients with advanced leukemias. Synonyms: TG02; TG 02; TG-02; SB1317 (Double bond E); TG02 (Double bond E). Grades: ≥98%. CAS No. 1204918-72-8. Molecular formula: C23H24N4O. Mole weight: 372.46. | |
| SB-200646A | SB-200646A is the first selective 5-HT 2B/2C over 5-HT 2A receptor antagonist with pK i values of 7.5, 6.9 and 5.2 for 5-HT 2B , 5-HT 2C and 5-HT 2A , respectively. SB-200646A is orally active and has electrophysiological and anxiolytic properties in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 143797-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103129. |  |
| SB 200646 hydrochloride | SB 200646 hydrochloride is an orally bioactive 5-HT2C/2B receptor antagonist displaying selectivity over 5-HT1A. Synonyms: SB 200646 hydrochloride; SB200646 hydrochloride; SB-200646 hydrochloride; N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea; 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea hydrochloride. Grades: ≥98% by HPLC. CAS No. 143797-62-0. Molecular formula: C15H14N4O.HCl. Mole weight: 302.76. | |
| SB202190 | SB202190, also named FHPI, under the IUPAC name 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one, is a pyridinyl imidazole that selectively inhibits the p38α and β isoforms. IC50=50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively. Uses: A highly selective, potent and cell-permeable inhibitor of p38 map kinase(ic50 = 50 and 100 nm at sapk2a/p38 and sapk2b/p38β2) respectively). Synonyms: 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; SB 202190; SB-202190; SB202190; SB 202190; 152121-30-7; SB-202190; SB202190; FHPI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; CHEBI:79090; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole; SB 202190, Immobilized; InSolution SB 202190; IN1110; IN1113; MFCD00941964; 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl)phenol; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole; 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol; 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol; C20H14FN3O; SB202190 (FHPI); SB202190, 152121-30-7; Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-i.. Grades: >98%. CAS No. 152121-30-7. Molecular formula: C20H14FN3O. Mole weight: 331.34. | |
| SB 202190 | Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Group: Biochemicals. Alternative Names: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol. Grades: Highly Purified. CAS No. 152121-30-7. Pack Sizes: 5mg. Molecular Formula: C20H14FN3O. US Biological Life Sciences. | Worldwide |
| SB 202190 | SB 202190 is a selective p38 MAP kinase inhibitor with IC 50 s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38 kinase with a K d of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits [1] [2]. SB202190 induces autophagy [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 152121-30-7. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-10295. | |
| SB202190 (FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole) | Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Group: Biochemicals. Alternative Names: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole. Grades: Highly Purified. CAS No. 152121-30-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H14FN3O. US Biological Life Sciences. | Worldwide |
| SB 202190 hydrochloride | SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC 50 s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a K d of 38 nM. SB 202190 hydrochloride has anti-cancer activity [1] [2]. SB202190 hydrochloride induces autophagy [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 350228-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10295A. | |
| SB 202190 hydrochloride | SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, effective against p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. It inhibits p38 MAP kinases, resulting in blockade of tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production in monocytes. Synonyms: SB 202190 HCl; 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol hydrochloride. Grades: ≥98%. CAS No. 350228-36-3. Molecular formula: C20H14FN3O·HCl. Mole weight: 367.8. | |
| SB 202190 hydrochloride | SB 202190 hydrochloride. Group: Biochemicals. Alternative Names: 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride. Grades: Highly Purified. CAS No. 350228-36-3. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C20H15ClFN3O. US Biological Life Sciences. | Worldwide |
| SB 202474 | SB 202474 is an analog of SB 202190 and SB 203580, which are inhibitors of the MAP kinases p38α and p38&beta. SB 202474 has been used as a negative control in studies of p38 inhibition. Synonyms: SB-202474; SB202474; 4-[5-ethyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl]pyridine. Grades: ≥97%. CAS No. 172747-50-1. Molecular formula: C17H17N3O. Mole weight: 279.3. | |
| SB 203186 hydrochloride | SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors. Synonyms: SB 203186 HCl; SB 203186 HCl; SB203186; SB-203186. 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride. Grades: ≥99% by HPLC. CAS No. 207572-69-8. Molecular formula: C16H20N2O2.HCl. Mole weight: 308.81. | |
| SB-203207 | SB-203207 is a tRNA synthetase inhibitor produced by Streptomyces sp. NCIMB 40513. Synonyms: SB 203207; SB203207. Molecular formula: C19H31N5O8S. Mole weight: 489.5. | |
| SB-203208 | SB-203208 is a tRNA synthetase inhibitor produced by Streptomyces sp. NCIMB 40513. Synonyms: SB 203208; SB203208. Molecular formula: C29H42N6O9S. Mole weight: 650.7. | |
| SB203580 | Cas No. 152121-47-6. | |
| SB 203580 | SB 203580 Inhibitor. Uses: Scientific use. Product Category: T1764. CAS No. 152121-47-6. |  |
| SB-203580 | SB 203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM, also blocks PKB phosphorylation with IC50 of 3-5 μM. Uses: Enzyme inhibitors. Synonyms: SB203580; SB203580; SB 203580. Grades: >98%. CAS No. 152121-47-6. Molecular formula: C21H16FN3OS. Mole weight: 377.437. | |
| SB 203580 hydrochloride | SB 203580 hydrochloride is a water-soluble form of the potent MAP kinase inhibitor SB 203580 with IC50 values of 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. It was shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Synonyms: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole hydrochloride. Grades: >98%. CAS No. 869185-85-3. Molecular formula: C21H17FN3OSCl. Mole weight: 413.9. | |
| SB 203580 Hydrochloride Salt | SB 203580 Hydrochloride Salt. Group: Biochemicals. Alternative Names: 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; hydrochloride; SB203580 hydrochloride; SCHEMBL4890447; HY-10256A. Grades: Highly Purified. CAS No. 869185-85-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C21 H16 FN 3 , Molecular Weight: 413.9. US Biological Life Sciences. | Worldwide |
| SB 204070 | SB 204070 is a potent and selective 5-HT4 receptor antagonist (pIC50 = 10.1), displaying >5000-fold selectivity over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, and 5-HT3 receptors. SB 204070 exhibits anxiolytic activity upon systemic administration in vivo. Uses: Serotonin antagonists. Synonyms: 1,4-Benzodioxin-5-carboxylic acid, 8-amino-7-chloro-2,3-dihydro-, (1-butyl-4-piperidinyl)methyl ester; (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-carboxylate; (1-Butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate; SB204070; SB-204070; (1-Butylpiperidin-4-yl)methyl 8-amino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate. Grades: ≥95%. CAS No. 148702-58-3. Molecular formula: C19H27ClN2O4. Mole weight: 382.88. | |
| SB 204741 | SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95) with ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors. Synonyms: SB 204741; SB204741; SB-204741. N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea; 1-(1-methyl-1H-indol-5-yl)-3-(3-methylisothiazol-5-yl)urea. Grades: ≥99% by HPLC. CAS No. 152239-46-8. Molecular formula: C14H14N4OS. Mole weight: 286.35. | |
| SB 204990 | SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. Uses: Scientific research. Group: Signaling pathways. CAS No. 154566-12-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-16450. | |
| SB 204990 | SB 204990 is a prodrug of SB 201076, which is an ATP citrate lyase (ACLY) inhibitor. SB 204990 inhibits cholesterol and fatty acid synthesis in a dose-dependent manner in HepG2 cells. SB 204990 was shown to decrease plasma levels of the lipoproteins VLDL, LDL, and HDL in dogs. Synonyms: SB-204990; SB 204990; SB204990; (3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid. Grades: ≥98% by HPLC. CAS No. 154566-12-8. Molecular formula: C18H22Cl2O5. Mole weight: 389.27. | |
| SB 205384 | SB 205384. Group: Biochemicals. Grades: Purified. CAS No. 160296-13-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB 205384 | SB 205384 is a GABAA receptor modulator. SB 205384 potentiates α6, α3 and α5-subunit-containing receptors (EC50 = 280, 695 and 730 nM, respectively). It exhibits little effect on receptors which contains α1 or α2 subunits. Synonyms: SB 205384; SB-205384; SB205384. 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester. Grades: ≥98% by HPLC. CAS No. 160296-13-9. Molecular formula: C17H18N2O3S. Mole weight: 330.4. | |
| SB 205607 dihydrobromide | SB 205607 dihydrobromide is the first described non-peptide δ1 opioid receptor agonist with high affinity and selectivity for the δ1 subtype (Ki = 1.12, 2320 and 1790 nM at δ1, μ and κ receptors, respectively). Synonyms: TAN67; TAN-67; TAN 67; SB-205607 dihydrobromide; SB 205607 dihydrobromide; SB205607 dihydrobromide; SB 205607 2HBr; SB205607 2HBr; SB-205607 2HBr; (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide. Grades: ≥97% by HPLC. CAS No. 1217628-73-3. Molecular formula: C23H24N2O.2HBr. Mole weight: 506.28. | |
| SB 206553 hydrochloride | SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2=8.89, human 5-HT2C pKi=7.92) with > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). Synonyms: SB 206553 HCl; SB 206553; SB206553; SB-206553; 3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride; 1-methyl-N-pyridin-3-yl-6,7-dihydropyrrolo[2,3-f]indole-5-carboxamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1197334-04-5. Molecular formula: C17H16N4O.HCl. Mole weight: 328.8. | |
| SB 206553 hydrochloride | SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT 2B / 5-HT 2C receptor antagonist (rat 5-HT 2B pA2 = 8.89, human 5-HT 2C pKi = 7.92) [1]. SB 206553 possesses anxiolytic-like properties [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1197334-04-5. Pack Sizes: 5 mg. Product ID: HY-103135. | |
| SB 206553 Hydrochloride (5-HT2C Serotonin Receptor Antagonist, SB 206553, 5-HT2B Serotonin Receptor Antagonist, SB 206553, SB206553, SB-206553) | A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5nM) and 5-HT2AR (Ki = 2,300nM). Group: Biochemicals. Grades: Highly Purified. CAS No. 158942-04-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O·HCl. US Biological Life Sciences. | Worldwide |
| SB-209670 | SB-209670 has been found to be an endothelin receptor antagonist that was once studied against arrhythmias and hypertension. Synonyms: SCHEMBL4197810; L001486; (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid; SB-209670; SB 209670; SB209670. Grades: 98%. CAS No. 157659-79-5. Molecular formula: C29H28O9. Mole weight: 520.53. | |
| SB 215505 | SB 215505 is a potent and orally bioactive 5-HT2B/2C receptor antagonist (pKi = 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A, respectively). SB 215505 increases wakefulness and motor activity in rats. Synonyms: SB215505; SB 215505; SB-215505. 6-Chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-1H-indole-1-carboxamide. Grades: ≥98% by HPLC. CAS No. 162100-15-4. Molecular formula: C19H16ClN3O. Mole weight: 337.81. | |
| SB-216 | SB-216 is a potent tubulin polymerization inhibitor. SB-216 shows strong antiproliferative potency in a panel of human cancer cell lines, including melanoma, lung cancer, and breast cancer. SB-216 can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756818-39-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144898. | |
| SB 216641 hydrochloride | SB 216641 hydrochloride is a selective h5-HT1B antagonist with ~ 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types. Synonyms: SB216641 hydrochloride; SB-216641 hydrochloride; N-[3-[2-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide Monohydrochloride; [1,1'-Biphenyl]-4-carboxamide, N-[3-[2-(dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-, hydrochloride (1:1); [1,1'-Biphenyl]-4-carboxamide, N-[3-[2-(dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-, monohydrochloride; SB 216641A; SB216641A; SB-216641A. Grades: ≥98% by HPLC. CAS No. 193611-67-5. Molecular formula: C28H30N4O4.HCl. Mole weight: 523.03. | |
| SB 216763 | SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC 50 s of 34.3 nM for both GSK-3α and GSK-3&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 280744-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12012. | |
| SB-216763 | SB216763 is a glycogen synthase kinase-3 (GSK3) inhibitor. It can maintain mouse embryonic stem cells (mESCs) in a pluripotent state in the absence of exogenous leukemia inhibitory factor (LIF) when cultured on mouse embryonic fibroblasts (MEFs). Synonyms: SB-216763; 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Grades: >98%. CAS No. 280744-09-4. Molecular formula: C19H12Cl2N2O2. Mole weight: 371.217. | |
| SB216763 (3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole- 2,5-dione) | The maleimide derivative SB216763 is a potent and selective cell permeable inhibitor of glycogen synthase kinase 3 (GSK-3). Research studies using peptide-based protein kinase assays show that SB216763 inhibits GSK-3alpha in an ATP competitive manner with an IC50 of 34nM, and is an equally effective GSK3-B inhibitor. Similar assays demonstrate that SB216763 (at concentrations up to 10uM) does not inhibit as many as 24 other serine/threonine and tyrosine protein kinases (1). As a consequence of inhibiting GSK-3, SB216763 stimulates glycogen synthesis in human liver cells (EC50 3.6uM) via glycogen synthase activation and induces expression of a B-catenin regulated reporter gene in HEK293 cells (1). Furthermore, SB216763 induces accumulation of B-catenin, a key downstream effector in the Wnt signaling pathway, in many cell types (2-5). Additional research indicates that SB216763 can prevent neuronal cell death induced by PI3 kinase pathway inhibition (2). Glycogen synthase kinase 3 inhibi Group: Biochemicals. Grades: Highly Purified. CAS No. 280744-09-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| SB 216763 (SB216763, SB-216763, SCHEMBL30251) | SB 216763 is a potent and selective ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3), including the alpha and beta isozymes. It displays neuroprotectant properties and stimulates glycogen synthesis in liver cells. SB 216763 is reported to be used to maintain the undifferentiated state of mouse embryonic stem cells. Group: Biochemicals. Alternative Names: 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione. Grades: Highly Purified. CAS No. 280744-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SB 218078 | SB 218078. Group: Biochemicals. Grades: Purified. CAS No. 135897-06-2. Pack Sizes: 1mg, 10mg. US Biological Life Sciences. | Worldwide |
| SB-218078 | SB-218078 is a potent and selective indolocarbazole chk1 inhibitor. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics. Synonyms: SB218078; SB 218078; SB-218078. Grades: ≥98%. CAS No. 135897-06-2. Molecular formula: C24H15N3O3. Mole weight: 393.40. | |
| SB 218795 | SB 218795 is a potent and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3) displaying 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. SB 218795 inhibits agonist-induced pupillary constriction. Synonyms: SB-218795; SB218795; SB 218795; (R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl ester benzeneacetic acid; methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate. Grades: ≥99% by HPLC. CAS No. 174635-53-1. Molecular formula: C25H20N2O3. Mole weight: 396.44. | |
| SB-219383 | SB-219383 is a tyrosyl tRNA synthetase inhibitor produced by Micromonospora sp. NCIMB 40684. Synonyms: SB 219383; SB219383. Molecular formula: C17H23N3O9. Mole weight: 413.4. | |
| SB 221284 | SB 221284 is a potent and selective 5-HT2C/2B receptor antagonist (pKi = 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors, respectively). Synonyms: SB 221284; SB221284; SB-221284. 2,3-Dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-1H-indole-1-carboxamide. Grades: ≥99% by HPLC. CAS No. 196965-14-7. Molecular formula: C16H14F3N3OS. Mole weight: 353.36. | |
| SB 222200 | SB 222200 is a brain penetrating and non-peptide NK3 receptor antagonist (Ki = 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors, respectively) that exhibits antihypertensive activity in vivo. Synonyms: SB-222200; SB222200; SB 222200; 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide. Grades: ≥98% by HPLC. CAS No. 174635-69-9. Molecular formula: C26H24N2O. Mole weight: 380.48. | |
| SB-222200 | SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 174635-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15722. | |
| SB 223412 | SB 223412 is a brain penetrating and orally bioactive non-peptide NK3 receptor antagonist (Ki = 1, 144 and >100000 nM for human NK3, NK2 and NK1 receptors, respectively). SB 223412 was shown to inhibit NKB-induced Ca2+ mobilization in vitro (IC50 = 16.6 nM) and NK3-agonist-induced behavioral responses in vivo. SB 223412 can be used as an antispychotic. Synonyms: SB 223412; SB223412; SB-223412; 3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide; 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 174636-32-9. Molecular formula: C25H22N2O2. Mole weight: 382.45. | |
| SB 224289A | SB 224289A. Group: Biochemicals. Alternative Names: [2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)-methanone Hydrochloride. Grades: Highly Purified. CAS No. 180084-26-8. Pack Sizes: 10mg. Molecular Formula: C32H33ClN4O3, Molecular Weight: 557.08. US Biological Life Sciences. | Worldwide |
| SB 224289 hydrochloride | SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2) displaying > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. SB 224289 exhibits anxiolytic activity. Synonyms: SB224289 hydrochloride; SB-224289 hydrochloride; 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride; [4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone hydrochloride; Methanone, [2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)-, hydrochloride (1:1); Spiro[2H-furo[2,3-f]indole-3(5H),4'-piperidine], 6,7-dihydro-1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]carbonyl]-, monohydrochloride; SB 224289A; SB224289A; SB-224289A. Grades: ≥95% by HPLC. CAS No. 180084-26-8. Molecular formula: C32H32N4O3.HCl. Mole weight: 557.09. | |
| SB-224289 hydrochloride | SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-224289A. CAS No. 180084-26-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101105A. | |
| SB 22484 | SB 22484 is a member of the aurodox type antibiotic group produced in submerged-fermentation cultures of Streptomyces sp. NRRL 15496. It is composed of two pairs of isomers with MW's of 752 and 766. It strongly inhibited neisseriae and were also active against Streptococci, Ureaplasma urealyticum and Haemophilus influenzae. Synonyms: SB-22484; SB22484; Antibiotic SB 22484. | |
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