A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
An interesting synthetic intermediate. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences.
Worldwide
S-benzyl-L-cysteinol
S-benzyl-L-cysteinol. Group: Biochemicals. Alternative Names: L-Cysteinol(Bzl); H-L-Cys(Bzl)-ol. Grades: Highly Purified. CAS No. 85803-43-6. Pack Sizes: 2g, 5g, 10g, 25g. US Biological Life Sciences.
Worldwide
S-Benzyl-L-homocysteine
Intermediate in the preparation of L-(+)-Cystathionine. Group: Biochemicals. Alternative Names: L-2-Amino-4-(benzylthio)butyric Acid; S-(Phenylmethyl)-L-homocysteine;2-Amino-4-benzylthiobutyric Acid; NSC 164657; NSC 206263. Grades: Highly Purified. CAS No. 7689-60-3. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
S-Benzyl-N-Boc-ethanethiolamine
S-Benzyl-N-Boc-ethanethiolamine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
S-Benzyl-N-Stearoyl-L-cysteine
S-Benzyl-N-Stearoyl-L-cysteine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Sbf I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 37°C in a total reaction volume of 50 μl. Applications: After 5-fold overdigestion with enzyme more than 90% of the dna fragments can be ligated and of these more than 90% canrecut. Group: Restriction Enzymes. Purity: 200U; 1000U. CCTGCA↑GG GG↓ACGTCC. Activity: 5000u.a./ml. Appearance: 10 X SE-buffer Y. Storage: -20°C. Form: Liquid. Source: An E.coli strain that carries the cloned Sbf I gene from Streptomyces species Bf61. Pack: 10 mM Tris-HCl (pH 7.6); 50 mM NaCl; 0.1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1170RE.
SBFI-26
SBFI-26 competitively inhibits the activities of FABP5 and FABP7. Group: Inhibitors. CAS No. 1541209-75-9. Pack Sizes: 5mg. Product ID: S9957. Formula: C28H22O4. Smiles: OC(=O)C1C(C(C1C2=CC=CC=C2)C(=O)OC3=C4C=CC=CC4=CC=C3)C5=CC=CC=C5. Storage Conditions: 3 years -20°C powder.
United States; Europe
SBFI-AM
SBFI-AM is a Na+ selective fluorescent indicator. SBFI-AM shows selectivity for Na+ over K+ with Kd values of 6.7 and 166 mM, respectively (Ex = 340/380 nm; Em = 500 nm)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 129423-53-6. Pack Sizes: 281 μg (5 mM * 50 μL in DMSO). Product ID: HY-126831.
SBFI tetraammonium
SBFI (tetraammonium), the tetraammonium salt of SBFI, is a cell-impermeant sodium fluorescence indicator. SBFI (tetraammonium) is sodium-sensitive dye. The excitation wavelength is set 333 nm, and the emission wavelength is 539 nm for SBFI[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172651-12-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1442.
SBHA
SBHA. Group: Biochemicals. Grades: Purified. CAS No. 38937-66-5. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
SBI-0206965
SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1884220-36-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16966.
SBI-0206965
SBI-0206965 is a highly selective autophagy kinase ULK1 inhibitor with IC50 of 108 nM, about 7-fold selectivity over ULK2. SBI-0206965 inhibits autophagy and enhances apoptosis in human glioblastoma and lung cancer cells. Group: Inhibitors. CAS No. 1884220-36-3. Pack Sizes: 5mg. Product ID: S7885. Formula: C21H21BrN4O5. Smiles: CNC(=O)C1=CC=CC=C1OC2=NC(=NC=C2Br)NC3=CC(=C(C(=C3)OC)OC)OC. Storage Conditions: 2 years -80 in solvent.
United States; Europe
SBI-0640756
SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SBI-756. CAS No. 1821280-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19560.
SBI-115
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 882366-16-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111534.
SBI-425
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1451272-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124756.
SBI-425
SBI-425 is a potent, selective and oral bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.016 μM. In vivo studies demonstrate that SBI-425 suppresses aortic calcification in mice that overexpress TNAP in smooth muscle cells, resulting in reduced aortic calcification and increased life-span. Alternative Names: 5-(5-Chloro-2-methoxyphenylsulfonamido)nicotinamide. Grades: 99%. CAS No. 1451272-71-1. Molecular formula: C13H12ClN3O4S. Mole weight: 341.77.
SBI-477
SBI-477 is a chemical probe that stimulates insulin signaling by deactivating the transcription factor MondoA. SBI-477 can lead to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 781628-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-124418.
SBI-553
SBI-553 is a brain-penetrant allosteric modulator of neurotensin receptor 1 (NTSR1). SBI-553 reduces stimulant effects without the side effects of unbiased NTSR1 agonists. Alternative Names: SBI 553; SBI553. CAS No. 1849603-72-0. Molecular formula: C26H31FN4O2. Mole weight: 450.5.
SBI-553
SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1849603-72-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125880.
SBI-797812
SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2237268-08-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126255.
SBI-810 hydrochloride is a blood-brain barrier-permeable NTSR1 modulator. SBI-810 hydrochloride promotes the recruitment of β-arrestin-2 to NTSR1 and antagonizes NTSR1-mediated Gq activation. SBI-810 hydrochloride inhibits excitatory synaptic transmission, NMDA receptor and extracellular signal-regulated kinase (ERK) signaling in spinal nociceptive neurons, reduces surface expression of Nav1.7 and action potential firing in primary sensory neurons, and attenuates C-fiber responses. SBI-810 hydrochloride effectively alleviates acute and chronic pain in various rodent models through peripheral and central modulation. SBI-810 hydrochloride is applicable to research related to multiple pain disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2772746-58-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164795A.
SBI-993
SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2073059-82-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122682.
S-Boc-2-mercapto-4,6-dimethylpyrimidine
S-Boc-2-mercapto-4,6-dimethylpyrimidine. Group: Biochemicals. Grades: Highly Purified. CAS No. 41840-28-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C11H16N2O2S. US Biological Life Sciences.
Worldwide
S-Boc-4,6-dimethyl-2-mercaptopyrimidine
Reagent for the preparation of Boc-amino acids. Alternative Names: Boc-SDP. Grades: ≥ 98%. CAS No. 41840-28-2. Molecular formula: C11H16N2O2S. Mole weight: 240.30.
S-Boc-4,6-dimethyl-2-mercaptopyrimidine 98+%
S-Boc-4,6-dimethyl-2-mercaptopyrimidine 98+%. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 5g, 25g. US Biological Life Sciences.
SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SBI-0636457; SB1-0636457. CAS No. 1422180-49-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125378.
SBP-1750
SBP-1750 is an orally active ULK inhibitor and an ATG13 degrader. SBP-1750 strongly inhibits ULK1/2 activity, with IC50 values of 8 and 50 nM, respectively. SBP-1750 induces ATG13 degradation, with an EC50 value of 114 nM. SBP-1750 can inhibit autophagy in cancer cells and induce cell death. SBP-1750 can be used in cancer research, such as for pancreatic cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1884219-70-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-179089.
SBP-3264
SBP-3264 is a YAP activator and STK/MST inhibitor with IC50 values of 36 nM against STK3/MST2 and 24 nM against STK4/MST1. SBP-3264 modulates the Hippo signaling pathway. SBP-3264 can be used for the research of acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2869148-13-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132969.
SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1884222-74-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137742.
SBSstandard 2D cryopreservation tube(Three yards in one)
SBS tubes preset QR bar, the tube cap designs of integrated sealing ring,which is in perfect airtightness to prevent liquid leakage.The grillage is designed for multi-replay function, and easily unlocked by the clasp.The grillage is designed for multi-replay function, and easily unlocked by the clasp. Product ID: PM-052. Category: cryopreservation tube. Product Keywords: Plastic Packaging; SBSstandard 2D cryopreservation tube(Three yards in one); PM-052; cryopreservation tube. Administration route: SBS grillage and SBS tubes are perfectly fit, which is convenient for high-throughput automation workstation. Dosage Form: 96 psc/box x 36 boxes, 48 psc/box x 36 boxes.
S-Butylglutathione
S-Butylglutathione. Group: Biochemicals. Grades: Highly Purified. CAS No. 6803-16-3. Pack Sizes: 250g, 500mg, 1g. Molecular Formula: C14H25N3O6S. US Biological Life Sciences.
Worldwide
S-Bz-Thiol-Modifier C6-dT
S-Bz-Thiol-Modifier C6-dT is a complex yet valuable biochemical agent utilized in the modification and labeling of nucleic acids. With its versatile combination of a benzylthiol group and a C6 modification, it has become an essential component in the preparation of oligonucleotides and the analysis of DNA-protein interactions. Its potential applications extend to the fields of genetic disorders and cancer research. For researchers seeking to probe and understand genetic mechanisms with precision and accuracy, S-Bz-Thiol-Modifier C6-dT stands out as an indispensable tool. Alternative Names: 5'-(4,4'-Dimethoxytrityl)-5-[N-(6-(3-benzoylthiopropanoyl)-aminohexyl)-3-acrylamido]-2'-deoxyuridine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C58H71N6O11PS. Mole weight: 1091.26.
SC-10
SC-10. Group: Biochemicals. Grades: Purified. CAS No. 102649-79-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SC-10
SC-10 is a direct activator of PKC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 102649-79-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100931.
SC144
SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 895158-95-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15614.
SC 144 hydrochloride
SC 144 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 917497-70-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SC144 hydrochloride
SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 917497-70-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15614A.
SC 19220
SC 19220. Group: Biochemicals. Grades: Purified. CAS No. 19395-87-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
SC209
SC209 (3-Aminophenyl Hemiasterlin) is a 3-aminophenyl hemiasterlin derivative that serves as a cytotoxin for ADCs, targeting tubulin. SC209 has reduced potential for drug efflux via P-glycoprotein 1 drug pump compared with other tubulin-targeting payloads. SC209 exhibits antitumor activity and can be used in the synthesis of ADC molecules[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Aminophenyl Hemiasterlin. CAS No. 1977557-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144880.
SC-236
SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 170569-86-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W010983.
SC 26196
SC 26196 is a selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro) that displays >100 fold selectivity over Δ5 and Δ9 desaturases (IC50 >200 μM in vitro). SC 26196 completely inhibits the conversion of linoleic acid to arachidonic acid (AA). It exhibits anti-inflammatory properties in a mouse edema model. Alternative Names: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; PF-o6341724; FT 0674530; SC 26196; FT0674530; SC26196; FT-0674530; SC-26196. Grades: ≥98% by HPLC. CAS No. 218136-59-5. Molecular formula: C27H29N5. Mole weight: 423.55.
SC-26196
SC-26196 is a potent, orally active Delta6 desaturase (D6D, FADS2) inhibitor (IC50=0.2 μM in a rat liver microsomal assay). Antiinflammatory properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 218136-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107410.
SC-28762
SC-28762 is an antibiotic produced by Spicaria divaricata NRRL 5771. It has moderate activity against gram-positive, gram-negative bacteria and fungi. Alternative Names: SC 28762; SC28762. CAS No. 35483-50-2. Molecular formula: C34H30O14. Mole weight: 662.6.
SC-28763
SC-28763 is an antibiotic produced by Spicaria divaricata NRRL 5771. It has activity against gram-positive, gram-negative bacteria and fungi, which is stronger than that of SC-28762. Alternative Names: SC 28763; SC28763. CAS No. 55051-93-9. Molecular formula: C34H30O13. Mole weight: 646.6.
SC-30532
SC-30532 is an antibiotic produced by Spicaria divaricata NRRL 5771. It has moderate activity against Clostridium perfringens and Trichomonas vaginolis at low concentrations. Alternative Names: SC 30532; SC30532. CAS No. 64596-90-3. Molecular formula: C34H30O12. Mole weight: 630.6.
SC428
SC428 is an androgen receptor (AR) inhibitor that targets the N-terminal domain. SC428 potently decrease the transactivation of (AR)-V7, (AR)v567es, as well as full-length ( AR ) (AR-FL) and its LBD mutants, substantially. SC428 inhibits androgen-stimulated (AR)-FL nuclear translocation, chromatin binding, and (AR) -regulated gene transcription. SC428 inhibits the proliferation of tumor cells in vitro. SC428 inhibits tumor cell growth by inducing apoptosis in mice transplanted with 22RV1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1898232-70-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164373.
SC-43
SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1400989-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136657.
SC-51089
A selective EP1 prostanoid receptor antagonist that attenuates prostaglandin E2-induced neuronal cell death in vitro and slows tumor growth in vivo. Its neuroprotective effect may potentially have therapeutic application in human stroke. Group: Biochemicals. Alternative Names: 8-Chloro-dibenz[b, f][1, 4]oxazepine-10(11H)-carboxylic Acid 2-[1-Oxo-3- (4-pyridinyl) propyl]hydrazide Hydrochloride; SC 51089. Grades: Highly Purified. CAS No. 146033-02-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
SC-51322
SC-51322 is a potent and selective antagonist of prostaglandin E2 (PGE2) receptor (EP 1), with a pA2 of 8.1. SC-51322 has the pain-relieving effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 146032-79-3. Pack Sizes: 1 mg. Product ID: HY-108562.
SC-514
SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GK 01140. CAS No. 354812-17-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13802.
SC-514
SC-514. Group: Biochemicals. Alternative Names: 5-(Thien-3-yl)-3-aminothiophene-2-carboxamide; 4-Amino-[2,3'-bithiophene]-5-carboxamide. Grades: Highly Purified. CAS No. 354812-17-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C9H8N2OS2. US Biological Life Sciences.