A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Alternative Names: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide; GS-4997; GS4997; GS 4997. Grades: ≥98%. CAS No. 1448428-04-3. Molecular formula: C24H24FN7O. Mole weight: 445.5.
Selpercatinib
Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LOXO-292. CAS No. 2152628-33-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114370.
Selpercatinib
Selpercatinib is a selective RET inhibitor with antineoplastic activity. It inhibits proliferation of cancer cells containing RET mutations or gene fusions. It is indicated for the treatment of non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC) and other thyroid cancer tumors. Alternative Names: LOXO-292; LOXO292; LOXO 292; ARRY-192; ARRY192; ARRY 192. CAS No. 2152628-33-4. Molecular formula: C29H31N7O3. Mole weight: 525.6.
Seltorexant hydrochloride
Seltorexant hydrochloride is an orally active and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride can cross the blood-brain barrier and quickly occupy OX2R binding sites in the rat brain. Alternative Names: JNJ-42847922 hydrochloride. Grades: 99%. CAS No. 1293284-49-7. Molecular formula: C21H23ClFN7O. Mole weight: 443.91.
Seltorexant hydrochloride
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-42847922 hydrochloride. CAS No. 1293284-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109012A.
Selumetinib
Selumetinib (AZD6244) is a MEK1/2 inhibitor that inhibits MEK1 (IC50=14 nM) with potent selectivity and is non-ATP-competitive. Selumetinib has antitumor activity and is used for the treatment of neurofibromatosis type 1 (NF1). Category: Active pharmaceutical ingredients. CAS No. 606143-52-6. Product ID: API606143526. Molecular formula: C17H15BrClFN4O3. Mole weight: 457.68.
Selumetinib
Selumetinib. Group: Biochemicals. Alternative Names: 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; ARRY 142886; AZD 6244. Grades: Highly Purified. CAS No. 606143-52-6. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C17H15BrClFN4O3. US Biological Life Sciences.
Worldwide
Selumetinib
Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. Alternative Names: ARRY-142886; ARRY 142886; ARRY142886; AZD6244; AZD-6244; AZD 6244; ARRY-886; ARRY886; ARRY 886. Grades: >98%. CAS No. 606143-52-6. Molecular formula: C17H15BrClFN4O3. Mole weight: 457.684.
Selumetinib
Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Selumetinib can penetrate the blood brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD6244; ARRY-142886. CAS No. 606143-52-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50706.
Selumetinib impurity 1
Selumetinib impurity 1. Uses: For analytical and research use. Molecular formula: C22H26N6O3. Mole weight: 422.49. Catalog: APB11628.
Selumetinib impurity 2
Selumetinib impurity 2. Uses: For analytical and research use. Molecular formula: C29H33N7O4. Mole weight: 543.63. Catalog: APB11629.
Selumetinib sulfate
Selumetinib sulfate (AZD6244 sulfate) is an orally available, selective and potent MEK1/2 inhibitor that inhibits MEK1/2 phosphorylation and may be useful for the study of symptomatic refractory fibroids in type 1 neurofibromatosis. Category: Active pharmaceutical ingredients. CAS No. 943332-08-9. Product ID: API943332089. Molecular formula: C17H17BrClFN4O7S. Mole weight: 555.76.
Selumetinib sulfate
Selumetinib (AZD6244) sulfate is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) sulfate inhibits ERK1/2 phosphorylation. Selumetinib sulfate can penetrate the blood brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD6244 sulfate; ARRY-142886 sulfate. CAS No. 943332-08-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50706A.
Selumetinib sulfate
Selumetinib is a selective, non-ATP-competitive oral MEK1/2 inhibitor. Selumetinib also inhibits ERK1/2 phosphorylation. Alternative Names: AZD-6244 hydrogen sulfate; Selumetinib (sulfate); AZD-6244 Hyd-Sulfate; NSC-748727; AZD6244 sulfate; ARRY-142886 sulfate. Grades: 99%. CAS No. 943332-08-9. Molecular formula: C17H17BrClFN4O7S. Mole weight: 555.76.
Selurampanel
Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BGG 492. CAS No. 912574-69-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-105860.
Selvigaltin
Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen). Selvigaltin restores T-cell activity and induces less tumors and metastasis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GB1211. CAS No. 1978336-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147041.
Semagacestat
Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY450139. CAS No. 425386-60-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10009.
Semagacestat
Semagacestat is an inhibitor of the γ-secretase enzyme. γ-Secretase enzyme is pivotal in the generation of β-amyloid (A β), a neurotoxic endogenous peptide believed to be involved in the pathogenesis of Alzheimer's disease (AD). Group: Biochemicals. Alternative Names: (2S) -2-Hydroxy-3-methyl-N- [ (1S) -1-methyl-2-oxo-2- [ [ (1S) -2, 3, 4, 5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl] amino] ethyl] butanamide; LY 450139. Grades: Highly Purified. CAS No. 425386-60-3. Pack Sizes: 10mg. US Biological Life Sciences.
Semaglutide is an oral agonist of glucagon-like peptide-1 receptor (GLP1R), used for treating type 2 diabetes and obesity by enhancing insulin secretion, reducing glucagon levels, and promoting weight loss. It is available in subcutaneous and oral formulations. Group: Inhibitors. CAS No. 910463-68-2. Pack Sizes: 1mg. Product ID: S9697.
United States; Europe
Semaglutide
Semaglutide is used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity. It also works by slowing the movement of food through the stomach and may decrease appetite and cause weight loss. Category: Peptide. Synonyms: Semaglutide impurity;semaglutide. CAS No. 910463-68-2. Product ID: PIPB-0170. Molecular formula: C187H291N45O59. Mole weight: 4113.57754. EINECS: 203-405-2. InChIKey: DLSWIYLPEUIQAV-CCUURXOWSA-N. Standard: US DMF/EDMF/CN CDE.
Semaglutide
Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 910463-68-2. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-114118.
Semaglutide
A long-acting GLP-1 analogue. Grades: Pharmaceutical grade. Product ID: PAP-0142.
Semaglutide acetate
Semaglutide acetate is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide acetate promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide acetate also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide acetate has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide acetate can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1997361-85-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-114118B.
Semaglutide Acetate
Semaglutide is an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. It reduces blood sugar via increasing the production of insulin. On Oct 18, 2017, Novo Nordisk received positive 16-0 vote from FDA Advisory Committee in favor of approval for Semaglutide. Grades: 98%. CAS No. 1997361-85-9. Molecular formula: C189H295N45O61. Mole weight: 4174.
Semaglutide (crude)
Semaglutide (crude) is the crude form of Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances Autophagy, inhibits oxidative stress and Apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 910463-68-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114118CP.
Semaglutide-[d15]
Semaglutide-[d15] is the labelled analogue of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: Semaglutide-d15; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val(D8)-Ser-Ser-Tyr-Leu(D7)-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C187H276D15N45O59. Mole weight: 4128.73.
Semaglutide D-Leu26
Semaglutide D-Leu26 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: D-Leu(26)-Semaglutide. Grades: 95%. Molecular formula: C187H291N45O59. Mole weight: 4113.64.
Semaglutide Impurity 16
Semaglutide Impurity 16 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: Glycine, N-L-α-glutamyl-, 5-(1,1-dimethylethyl) ester; Glutaramic acid, 4-amino-N-(carboxymethyl)-, 1-tert-butyl ester, L-; (S)-(2-amino-5-(tert-butoxy)-5-oxopentanoyl)glycine; H-Glu(OtBu)-Gly-OH; ({(2S)-2-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoyl}amino)acetic acid. CAS No. 23406-82-8. Molecular formula: C11H20N2O5. Mole weight: 260.29.
Semaglutide Impurity 1 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: L-Histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-(L-tryptophyl-hydroxybenzyl)-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-(Trp-hydroxybenzyl)-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C194H297N45O60. Mole weight: 4219.77.
Semaglutide Impurity 3 (P3 Semaglutide)
Semaglutide Impurity 3 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C126H206N30O36. Mole weight: 2717.21.
Semaglutide intermediate
Semaglutide intermediate is an intermediate of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: (S)-21,39-di-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 9,18,23-trioxo-2,5,11,14-tetraoxa-8,17,22-triazanonatriacontane-1,21,39-tricarboxylate; 17-((S)-1-tert-Butoxycarbonyl-3-{2-[2-({2-[2-(2,5-dioxopyrrolidin-1-yloxycarbonylmethoxy)ethoxy]ethylcarbamoyl}methoxy)ethoxy]-ethylcarbamoyl}propylcarbamoyl)heptadecanoic acid tert-butyl ester; Octadecanoic acid, 18-[[(1S)-1-[(1,1-dimethylethoxy)carbonyl]-22-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4,13,22-trioxo-8,11,17,20-tetraoxa-5,14-diazadocos-1-yl]amino]-18-oxo-, 1,1-dimethylethyl ester; Bis(2-methyl-2-propanyl) (22S)-1-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1,10,19,24-tetraoxo-3,6,12,15-tetraoxa-9,18,23-triazatetracontane-22,40-dicarboxylate; tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu. Grades: ≥95%. CAS No. 1118767-15-9. Molecular formula: C47H82N4O15. Mole weight: 943.19.
Semaglutide intermediate P29
An intermediate of Semaglutide, an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. Alternative Names: Semaglutide [sequence (9-37)]; L-α-Glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginylglycine; H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Grades: ≥95%. CAS No. 1169630-82-3. Molecular formula: C142H216N38O45. Mole weight: 3175.47.
Semaglutide Main Chain (9-37)
Semaglutide Main Chain (9-37) is a peptide starting material in the synthesis of semaglutide (HY-114118)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1169630-82-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Z11724.
Semaglutide Na salt form
Semaglutide Na salt form. CAS No. 910463-68-2. Purity: Min. 98%. Product ID: ALC-FP-910463682. Alfa Chemistry - ISO 9001:32057 Certified.
Semaglutide-[Phe-d5]
Semaglutide-[Phe-d5] is the labelled analogue of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: H-His-Aib-Glu-Gly-Thr-Phe(D5)-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH; Semaglutide D5; Semaglutide-d5. Molecular formula: C187H286D5N45O59. Mole weight: 4118.67.
Semaglutide-[Phe-d8]
Semaglutide-[Phe-d8] is the labelled analogue of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: H-His-Aib-Glu-Gly-Thr-Phe(D8)-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH; Semaglutide D8; Semaglutide-d8. Molecular formula: C187H283D8N45O59. Mole weight: 4121.69.
Semaglutide related compound 1
Semaglutide related compound 1 is an impurity of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: Semaglutide SZ Impurity 1; Semaglutide Iso Asp Impurity; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Iso-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Molecular formula: C187H291N45O59. Mole weight: 4113.64.
Semaglutide Sodium
Semaglutide Sodium (Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217), a long-acting glucagon-like peptide 1 (GLP-1) analogue, is a GLP-1 receptor agonist with the potential for the treatment of type 2 diabetes mellitus (T2DM). Group: Inhibitors. Alternative Names: Rybelsus, Ozempic, NN9535, OG217SC, NNC 0113-0217. CAS No. 910463-68-2(free base). Pack Sizes: 1mg. Product ID: E7333. Formula: C187H291N45O59. Storage Conditions: 3 years -20°C powder.
United States; Europe
Semaglutide sodium salt
Semaglutide is an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. It reduces blood sugar via increasing the production of insulin. On Oct 18, 2017, Novo Nordisk received positive 16-0 vote from FDA Advisory Committee in favor of approval for Semaglutide. Uses:
semaglutide, a glucagon-like peptide-1 (glp-1) receptor agonist, has shown promising applications in drug discovery due to its unique pharmacological properties. originally developed for the treatment of type 2 diabetes, semaglutide has recently gained attention for its potential in various therapeutic areas beyond diabetes management. this peptide-based drug has demonstrated efficacy in contro. Alternative Names: His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(PEG2-PEG2-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly; L-Histidyl-2-methylalanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-α-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ. Molecular formula: C187H291N45O59 (free base). Mole weight: 4113.64 (free base).
Semaglutide-[Val-d8] Tetratrifluoroacetate
Semaglutide-[Val-d8] Tetratrifluoroacetate is the labelled salt of Semaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist used to treat type 2 diabetes. Alternative Names: Semaglutide-d8 Tetratrifluoroacetate; L-histidyl-2-methylalanyl-L-a-glutamylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-a-aspartyl-L-valyl-d8-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-a-glutamylglycyl-L-glutaminyl-L-alanyl-L-alanyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-a-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-a-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-arginylglycyl-L-arginyl-Glycine, trifluoroacetic acid (1:4); H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val(D8)-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH.4TFA. Molecular formula: C187H283D8N45O59.4C2HF3O2. Mole weight: 4577.78.
Semapimod
An investigational new drug in a clinical trial for the treatment of Crohn's Disease. It exhibits anti-inflammatory, anti-cytokine, immunomodulatory, antiviral and antimalarial activities. Alternative Names: CNI-1493; CNI 1493; CNI1493; N,N'-bis[3,5-bis[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide. CAS No. 352513-83-8. Molecular formula: C34H52N18O2. Mole weight: 744.91.
Semapimod hydrochloride
Semapimod (INN), formerly known as CNI-1493, is a cytokine inhibitor. Semapimod is an investigational new drug which has anti-inflammatory, anti-cytokine, immunomodulatory, antiviral and antimalarial properties. Structurally, semapimod is synthetic guanylhydrazone mitogen-activated protein kinase blocker, as a potential treatment for Crohn's disease and other inflammatory conditions. Clinical trials of Semapimod started in 2001. Alternative Names: CNI-1493; CNI 1493; CNI1493; AXD455; AXD 455; AXD-455; AIDS121302; AIDS-121302; AIDS 121302. Grades: >98%. CAS No. 164301-51-3. Molecular formula: C34H56Cl4N18O2. Mole weight: 890.746.
Semapimod tetrahydrochloride
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50?0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNI-1493; CPSI-2364 tetrahydrochloride. CAS No. 164301-51-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15509A.
Sematilide hydrochloride
Sematilide hydrochloride. Alternative Names: Sematilide hydrochloride; Sematilide HCl; Sematilide hydrochloride; Sematilide; CK-1752A; CK1752A; CK 1752A; CK-1752; CK1752; CK 1752. CAS No. 101526-62-9. Purity: >98%. Product ID: ACM101526629-1. Molecular formula: C14H24ClN3O3S. Mole weight: 349.87. IUPAC Name: Benzamide, N-(2-(diethylamino)ethyl)-4-((methylsulfonyl)amino)-, monohydrochloride. Alfa Chemistry - ISO 9001:32057 Certified.
Semax
Semax is a peptide analog of adrenocorticotropic hormone (ACTH) (4-10). ACTH is a tropic hormone produced by the anterior pituitary. Uses: Enzyme inhibitors. Alternative Names: H-Met-Glu-His-Phe-Pro-Gly-Pro-OH; L-Proline, L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-; L-Methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline; L-Proline, 1-[N-[1-[N-[N-(N-L-methionyl-L-α-glutamyl)-L-histidyl]-L-phenylalanyl]-L-prolyl]glycyl]-; ACTH (4-7), Pro-Gly-Pro-; Pro-gly-pro-ACTH (4-7). Grades: 98%. CAS No. 80714-61-0. Molecular formula: C37H51N9O10S. Mole weight: 813.92.
Semax
Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80714-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1146.
Semax acetate
Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2828433-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1146A.
Semax acetate
Semax acetate is a synthetic adrenocorticotropic hormone (ACTH) (4-10) peptide analog with neuroprotective, analgesic, and anti-anxiety properties. Alternative Names: L-Proline, L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-, acetate (1:1); H-Met-Glu-His-Phe-Pro-Gly-Pro-OH acetate; L-Methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline acetate; L-Proline, 1-[N-[1-[N-[N-(N-L-methionyl-L-α-glutamyl)-L-histidyl]-L-phenylalanyl]-L-prolyl]glycyl]-, acetate. Grades: ≥95%. CAS No. 2828433-33-4. Molecular formula: C39H55N9O12S. Mole weight: 873.98.
Semaxanib (SU5416)
Semaxanib (SU5416, semaxinib) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. Phase 3.Semaxanib (SU5416) can be used to induce animal models of chronic intermittent hypoxia. Group: Inhibitors. Alternative Names: semaxinib. CAS No. 204005-46-9. Pack Sizes: 5mg. Product ID: S2845. Formula: C15H14N2O. Smiles: CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C. Storage Conditions: 2 years -80 in solvent.
Semaxinib (SU5416) is a potent and selective inhibitor of VEGFR (Flk-1/KDR) with an IC50 of 1.23 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SU5416. CAS No. 204005-46-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10374.
Semaxinib
Semaxinib is a quinolone derivative with potential antineoplastic activity. Semaxinib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. Uses: Angiogenesis inhibitors. Alternative Names: SU5416; SU-5416; SU 5416; Sugen 5416; semoxind. Grades: 98%. CAS No. 204005-46-9. Molecular formula: C15H14N2O. Mole weight: 238.28.
Semen Cassiae Extract. Applications: Used for health care products, dietary supplements, good for eyesight. Group: Others. Synonyms: Semen Cassiae Extract; Cassia obtusifolia L. Purity: 5:1, 10?1 By TLC. Appearance: Brown fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Seed. Species: Cassia obtusifolia L. Semen Cassiae Extract; Cassia obtusifolia L.; plant extract. Pack: 20KG-25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-108.
Semen Nelumbinis Extracellular Vesicles
Shipped on dry ice and stored at -80°C. Valid for 9 months. Grades: Biological reagent. Product ID: Exo-0040.
semenogelase
A peptidase of family S1 (trypsin family) from seminal plasma. Slowly inhibited by α1-antichymotrypsin. Group: Enzymes. Synonyms: prostate-specific antigen; α-seminoprotein; seminin; P-30 antigen; antigen (human clone HPSA-1 prostate-specific protein moiety reduced); γ-seminoglycoprotein (human protein moiety reduced); γ-SM; antigen PSA (human prostate-specific); human glandular kallikrein; antigen PSA (human clone 5P1 protein moiety reduced). Enzyme Commission Number: EC 3.4.21.77. CAS No. 110157-83-0, 95829-41-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4169; semenogelase; EC 3.4.21.77; 110157-83-0, 95829-41-7; prostate-specific antigen; α-seminoprotein; seminin; P-30 antigen; antigen (human clone HPSA-1 prostate-specific protein moiety reduced); γ-seminoglycoprotein (human protein moiety reduced); γ-SM; antigen PSA (human prostate-specific); human glandular kallikrein; antigen PSA (human clone 5P1 protein moiety reduced). Cat No: EXWM-4169.
Semen Ricini Extracellular Vesicles
Shipped on dry ice and stored at -80°C. Valid for 9 months. Grades: Biological reagent. Product ID: Exo-0024.
Semen Ziziphi Spinosae Extract
Semen Ziziphi Spinosae Extract is derived from the dried seeds of Ziziphus jujuba Mill.var.spinosa, a plant of the Rhamnaceae family. The active ingredients include flavonoid glycosides, triterpenes, saponins and organic acids, etc. Grades: 10:1.
Se-(Methyl)selenocysteine hydrochloride is an anticancer agent that inhibits cell cycle proliferation and induces apoptosis. Alternative Names: (2R)-2-amino-3-methylselanylpropanoic acid hydrochloride; (R)-2-Amino-3-(methylselanyl)propanoic acid hydrochloride; Se-MSC. Grades: >95%. CAS No. 863394-07-4. Molecular formula: C4H10ClNO2Se. Mole weight: 218.55.
Se-Methylselenocysteine (Standard)
Risedronic acid (Standard) is the analytical standard of Risedronic acid. This product is intended for research and analytical applications. 0. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Methylselenocysteine (Standard); Se-Methylseleno-L-cysteine (Standard). CAS No. 26046-90-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114245R.
Se-methyl-seleno-L-cysteine
Se-methyl-seleno-L-cysteine. CAS No: 26046-90-2
Sarchem Laboratories New Jersey NJ
Semialactone
Semialactone isolated from the barks of Rhus javanica L. Alternative Names: (2S,3R,4S)-4-(2-{[(2E)-3-(3,4-Dihydroxyphenyl)-2-propenoyl]oxy}et hyl)-2-(β-D-glucopyranosyloxy)-3-vinyl-3,4-dihydro-2H-pyran-5-car boxylic acid. Grades: 95%. CAS No. 366450-46-6. Molecular formula: C30H44O4. Mole weight: 468.7.
Semicarbazide
Semicarbazide. Alternative Names: Carbamylhydrazine. CAS No. 57-56-7. Molecular formula: CH5N3O. Mole weight: 75.07.
Semicarbazide-13C,15N2 hydrochloride
Semicarbazide-13C,15N2 hydrochloride is 15N and 13C labeled Semicarbazide. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aminourea-13C,15N2 hydrochloride; Hydrazinecarboxamide-13C,15N2 hydrochloride. CAS No. 1173020-16-0. Pack Sizes: 10 mg. Product ID: HY-W067028S.