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| Product | Description | |
|---|---|---|
| Sitagliptin Impurity 77 | Sitagliptin Impurity 77. Uses: For analytical and research use. Molecular formula: C16H20F3NO2. Mole weight: 315.34. Catalog: APB09568. |  |
| Sitagliptin Impurity 79 | Sitagliptin Impurity 79. Uses: For analytical and research use. Alternative Names: 5-(2-(2,5-difluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione. Molecular formula: C14H12F2O5. Mole weight: 298.24. Catalog: APB01746. | |
| Sitagliptin Impurity 80 | Sitagliptin Impurity 80. Uses: For analytical and research use. Alternative Names: 5-(2-(2,4-difluorophenyl)-1-hydroxyethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione. Molecular formula: C14H12F2O5. Mole weight: 298.24. Catalog: APB01745. | |
| Sitagliptin Impurity 83 | Sitagliptin Impurity 83. Uses: For analytical and research use. Alternative Names: 7-nitroso-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine. CAS No. 2892260-32-9. Molecular formula: C6H6F3N5O. Mole weight: 221.14. Catalog: APB2892260329. | |
| Sitagliptin Intermediate 2 | Sitagliptin Intermediate 2 is a useful organic compound that has been used in life science related research. Category: Active pharmaceutical ingredients. CAS No. 762240-92-6. Product ID: API762240926. Molecular formula: C6H8ClF3N4. Mole weight: 228.603. |  |
| Sitagliptin Methyl-Ester Impurity HCl | Sitagliptin Methyl-Ester Impurity HCl. Uses: For analytical and research use. CAS No. 1374985-05-3. Molecular formula: C11H13ClF3NO2. Mole weight: 283.68. Catalog: APB1374985053. | |
| Sitagliptin N-sulfate | Sitagliptin N-sulfate. Group: Biochemicals. Alternative Names: N-[ (1R) -3-[5, 6-Dihydro-3- (trifluoromethyl) -1, 2, 4-triazolo[4, 3-a]pyrazin-7 (8H) -yl]-3-oxo-1-[ (2, 4, 5-trifluorophenyl) methyl]propyl]sulfamic acid. Grades: Highly Purified. CAS No. 940002-57-3. Pack Sizes: 1mg, 2mg, 5mg, 10mg. Molecular Formula: C16H15F6N5O4S. US Biological Life Sciences. |  Worldwide |
| Sitagliptin phosphate | Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor. Category: Active pharmaceutical ingredients. Synonyms: Januvia, MK-0431 phosphate, Sitagliptin (phosphate). CAS No. 654671-78-0. Product ID: API654671780. Molecular formula: C16H18F6N5O5P. Mole weight: 505.31. | |
| Sitagliptin phosphate | Sitagliptin phosphate is the phosphate salt form of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Uses: Hypoglycemic agents. Synonyms: (2R)-4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate salt; MK-431; ONO-5435. Grade: >98%. CAS No. 654671-78-0. Molecular formula: C16H15F6N5O.H3O4P. Mole weight: 505.31. |  |
| Sitagliptin phosphate | Sitagliptin (MK-0431) phosphate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (K? = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0431 phosphate. CAS No. 654671-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg. Product ID: HY-13749A. |  |
| Sitagliptin Phosphate | Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes. Group: Biochemicals. Alternative Names: 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-phosphate. Grades: Highly Purified. CAS No. 654671-78-0. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Sitagliptin phosphate monohydrate | Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent DPP-IV inhibitor with an IC50 of 19 nM in Caco-2 cell extracts. Category: Active pharmaceutical ingredients. Synonyms: MK-0431, MK-0431 phosphate monohydrate. CAS No. 654671-77-9. Product ID: API654671779. Molecular formula: C16H15F6N5O·H3PO4·H2O. Mole weight: 523.33. | |
| Sitagliptin phosphate monohydrate | Sitagliptin (MK-0431) phosphate monohydrate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin phosphate monohydrate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (K? = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate monohydrate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate monohydrate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate monohydrate can be used for the study of 1-type and 2-type diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0431 phosphate monohydrate. CAS No. 654671-77-9. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13749B. | |
| Sitagliptin Phosphate Monohydrate (7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate, MK-0431) | An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release, stimulates the insulin release and lowers blood glucose. Group: Biochemicals. Grades: Highly Purified. CAS No. 654671-77-9. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Sitagliptin Related Compound 1 | Sitagliptin Related Compound 1 is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: (R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid; Boc-(R)-3-amino-4-(3-fluorophenyl)-butyric acid. Grade: >95%. CAS No. 331763-66-7. Molecular formula: C15H20FNO4. Mole weight: 297.32. | |
| Sitaxsentan sodium | Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IPI 1040 sodium; TBC11251 sodium. CAS No. 210421-74-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-11103. | |
| Sitaxsentan sodium | Sitaxsentan sodium. Group: Biochemicals. Alternative Names: N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide. Grades: Highly Purified. CAS No. 210421-74-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C18H14ClN2NaO6S2. US Biological Life Sciences. | Worldwide |
| site-1 protease | Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream. The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages. The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys? site, and the envelope glycoprotein of the highly infectious Lassa virus and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys?. Belongs in. No. 167140-48-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4107; site-1 protease; EC 3.4.21.112; 167140-48-9; mammalian subtilisin/kexin isozyme 1; membrane-bound transcription factor site-1 protease; proprotein convertase SKI-1; proprotein convertase SKI-1/S1PPS1; S1P endopeptidase; S1P protease; site-1 peptidase; site-1 protease; SKI-1; SREBP proteinase; SREBP S1 protease; SREBP-1 proteinase; SREBP-2 proteinase; sterol regulatory element-binding protein proteinase; sterol regulatory element-binding protein site 1 protease; sterol-regulated luminal protease; subtilase SKI-1; subtilase SKI-1/S. |  |
| site-specific DNA-methyltransferase (adenine-specific) | This is a large group of enzymes, most of which form so-called 'restriction-modification systems' with nucleases that possess similar site specificity [the nucleases are listed as either EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease)]. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase. neb. com/rebase/rebase. html. Group: Enzymes. Synonyms: modification methylase; restriction-modification system. Enzyme Commission Number: EC 2.1.1.72. CAS No. 69553-52-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1974; site-specific DNA-methyltransferase (adenine-specific); EC 2.1.1.72; 69553-52-2; modification methylase; restriction-modification system. Cat No: EXWM-1974. | |
| site-specific DNA-methyltransferase (cytosine-N4-specific) | This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called 'restriction-modification systems'. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase. neb. com/rebase/rebase. html. Group: Enzymes. Synonyms: modification methylase; restriction-modification system; DNA[cytosine-N4]methyltransferase; m4C-forming MTase; S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase. Enzyme Commission Number: EC 2.1.1.113. CAS No. 169592-50-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1712; site-specific DNA-methyltransferase (cytosine-N4-specific); EC 2.1.1.113; 169592-50-1; modification methylase; restriction-modification system; DNA[cytosine-N4]methyltransferase; m4C-forming MTase; S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase. Cat No: EXWM-1712. | |
| Sitneprotafib | Sitneprotafib (JAB-3312) is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. Sitneprotafib has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JAB-3312. CAS No. 2245082-05-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161952. | |
| Sitoindoside I | Sitoindoside I. Alternative Names: 6-naphthalen-2-ylamino-1H-pyrimidine-2,4-dione. CAS No. 18749-71-8. Purity: 98%. Product ID: ACM18749718. Molecular formula: C51H90O7. Mole weight: 815.3. IUPAC Name: [(2R,3S,4S,5R,6R)-6-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxan-2-yl]methyl hexadecanoate. Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC1C(C(C(C(O1)OC2CCC3(C4CCC5(C(C4CC=C3C2)CCC5C(C)CCC(CC)C(C)C)C)C)O)O)O. Alfa Chemistry - ISO 9001:32057 Certified. |  |
| Sitostanol | Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and IL-10. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stigmastanol; 24α-Ethyl cholestanol. CAS No. 83-45-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113494. | |
| Sitostenone | Sitostenone is isolated from the roots of Xanthium sibiricum. Sitostenone has antioxidant activity and can be used in the treatment of androgen-dependent diseases, especially benign prostatic hyperplasia. Synonyms: Stigmast-4-en-3-one; (24R)-24-Ethylcholest-4-en-3-one; (24R)-Stigmast-4-en-3-one; 4-En-3-stigmastone; NSC 49082; β-Rosasterol oxide; β-Sitost-4-en-3-one; β-Sitostenone; Δ4-Sitosterol-3-one; beta-sitostenone. Grade: >98%. CAS No. 1058-61-3. Molecular formula: C29H48O. Mole weight: 412.69. | |
| Sitosterol | Sitosterol Inhibitor. Uses: Scientific use. Product Category: T2966. CAS No. 83-46-5. |  |
| Sitosterol-d7 | Sitosterol-d7. Group: Others. Purity: >99%. Mole weight: 421.75. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; Sitosterol-d7; (24-Ethyl)-heptadeuteriostigmast-5-en-3ss-ol. Cat No: FLBZ-078. | |
| Sitravatinib | Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGCD516; MG-516. CAS No. 1123837-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16961. | |
| Sivelestat | Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EI546; LY544349; ONO5046. CAS No. 127373-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17443. | |
| Sivelestat sodium | Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium. CAS No. 150374-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17443A. | |
| Sivelestat sodium salt | Sivelestat sodium salt. Group: Biochemicals. Grades: Purified. CAS No. 150374-95-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Sivelestat sodium tetrahydrate | Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate. CAS No. 201677-61-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17443B. | |
| Sivopixant | Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-600918. CAS No. 2414285-40-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-137451. | |
| Siyry | A Kb-restricted epitope peptide. CAS No. 178561-37-0. Molecular formula: C50H71N11O13. Mole weight: 1034.1600000000001. | |
| SIYRY acetate | A Kb-restricted epitope peptide. Molecular formula: C52H75N11O15. Mole weight: 1094.25. | |
| SJ000063181 | SJ000063181 is a potent BMP signaling activator. SJ000063181 activates BMP4 and the phosphorylation of SMAD1/5/8 (p-SMAD1/5/8). SJ000063181 induces ventralization in zebrafish embryos[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 945189-68-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147372. | |
| SJ000291942 | SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules. Uses: Scientific research. Category: Signaling pathways. CAS No. 425613-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112331. | |
| SJ 172550 | SJ 172550. Group: Biochemicals. Grades: Purified. CAS No. 431979-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SJ-172550 | SJ-172550 is a small molecule inhibitor of MDMX; competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 431979-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16664. | |
| SJ3149 | SJ3149 is a selective and potent molecular glue degrader of CK1α protein with broad antiproliferative activity. SJ3149 can be used in cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3026986-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160444. | |
| SJ572403 | SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SJ403. CAS No. 19970-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114712. | |
| SJ6986 | SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765625-93-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132199. | |
| SJB2-043 | SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 63388-44-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15757. | |
| SJB3-019A | SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070015-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-80012. | |
| SJF-0628 | SJF-0628 is a RAF PROTAC degrader. SJF-0628 induces targeted degradation of BRAF in various cancer cell lines (colorectal cancer cell lines (Colo-205, LS-411N, HT-29, RKO) and triple-negative breast cancer cell line DU-4475). SJF-0628 decreases pMEK and pErk levels in DU-4475 cells. SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of colorectal cancer and triple-negative breast cancer. (Pink: RAF ligand (HY-12057), Blue: VHL Ligand ( HY-125845), Black: Linker (HY-B0912))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2413035-41-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-136420. | |
| SJF-1521 | SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research. (Pink: EGFR ligand (HY-177379); Black: Linker (HY-128804); Blue: VHL Ligand (HY-125845))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230821-40-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131865. | |
| SJF 1528 | Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib (Cat. No. 6811) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells). Category: Active pharmaceutical ingredients. CAS No. 2230821-38-0. Product ID: API2230821380. Molecular formula: C55H57ClFN7O8S. Mole weight: 1030.61. | |
| SJF-1528 | SJF-1528 (PROTAC 1) is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 also degrades HER2. SJF-1528 promotes ubiquitination and degradation of EGFR and can be used in breast cancer research (Pink: ligand for target protein (HY-159047); Black: linker Tos-PEG2-CH2-Boc (HY-130532); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230821-38-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131864. | |
| SJG-136 | SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC-694501. CAS No. 232931-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14573. | |
| SJPYT-195 | SJPYT-195 is a cytotoxic GSPT1 degrader and can be used for PROTAC synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2973762-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150616. | |
| SJPYT-310 | SJPYT-310 is a selective PXR antagonist. SJPYT-310 shows no significant cytotoxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2883814-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-173072. | |
| SK1-I | SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 μM[1]. SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BML-258. CAS No. 1072443-89-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119016. | |
| SK1-IN-1 | SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1218816-71-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101805. | |
| SK-216 | SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 654080-03-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122714. | |
| SK2187 | SK2187 is a selective AURKA PROTAC degrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: E3 ligand (HY-103597); Black: Linker: Amino-PEG3-alcohol (HY-W015088))[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JB301. CAS No. 3038446-91-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-171768. | |
| SK2188 | SK2188 is a highly efficient and selective PROTAC degrader targeting AURKA (DC50 = 3.9 nM). SK2188 induces DNA damage and cell apoptosis. SK2188 indirectly degrades MYCN, inhibits tumor cell proliferation, and provides insights into the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 (HY-13252); Blue: Thalidomide (HY-14658); Black: Linker: Amino-PEG4-alcohol (HY-W008005))[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JB325. CAS No. 3038446-94-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-171767. | |
| SK33 | SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1928724-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135732. | |
| SK-3-91 | SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades YTHDF2. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397))[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2769753-23-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137341. | |
| SK-575 | SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2523016-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139156. | |
| SKA 31 | SKA 31. Group: Biochemicals. Grades: Purified. CAS No. 40172-65-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Skeletal muscle-targeted peptide MSP | Skeletal muscle-targeted peptide MSP is a 7-amino-acid (ASSLNIA) muscle-targeting peptide (MTP). Skeletal muscle-targeted peptide MSP can target the virus through a different binding ligand to the muscle. Skeletal muscle-targeted peptide MSP can be used for the research of diseases of the heart and skeletal muscles[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 216763-24-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10643. | |
| Skepinone-L | Skepinone-L (CBS3830), a chemical probe, is a selective p38 mitogen-activated protein kinase inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CBS3830. CAS No. 1221485-83-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15300. | |
| SKF-34288 hydrochloride | SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride. CAS No. 320386-54-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128923. | |
| SKF 38393 hydrobromide | SKF 38393 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 20012-10-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| SKF 38393 hydrochloride | SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-SKF-38393 hydrochloride; SKF-38393A. CAS No. 62717-42-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12520A. | |
| SKF 81297 | SKF 81297 is a potent and selective dopamine D1 receptor agonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 71636-61-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12236A. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67287-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12236. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 67287-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF-82958 hydrobromide | SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-SKF-82958 hydrobromide; Chloro-APB hydrobromide. CAS No. 74115-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10435A. | |
| SKF-83566 | SKF-83566 is a potent, blood-brain permeable and orally active D1-like dopamine receptor (D1DR) antagonist and a weaker competitive antagonist at the vascular 5-HT2 receptor (Ki=11 nM)[1][3]. SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50 of 5.7 μM[2]. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta[4]. SKF-83566 can be used for research of parkinsons disease and nicotine craving alleviation[5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 99295-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-103430A. | |
| SKF 83822 hydrobromide | SKF 83822 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 74115-10-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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